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AP3M1 Gene

protein-coding   GIFtS: 56
GCID: GC10M075880

Adaptor-Related Protein Complex 3, Mu 1 Subunit

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adaptor-Related Protein Complex 3, Mu 1 Subunit1 2     AP-3 Complex Subunit Mu-12
Adapter-Related Protein Complex 3 Subunit Mu-12 3     Clathrin Adaptor Complex AP3, Mu-3A Subunit2
Mu-Adaptin 3A2 3     mu3A-adaptin2
AP-3 Adapter Complex Mu3A Subunit2 3     Mu3A-adaptin3
Adapter-Related Protein Complex 3 Mu-1 Subunit2     

External Ids:    HGNC: 5691   Entrez Gene: 269852   Ensembl: ENSG000001850097   OMIM: 6103665   UniProtKB: Q9Y2T23   

Export aliases for AP3M1 gene to outside databases

Previous GC identifers: GC10M074835 GC10M074984 GC10M075773 GC10M075226 GC10M075551 GC10M069875


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AP3M1 Gene:
The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex
associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the
budding of vesicles from the Golgi membrane and may be directly involved in protein sorting to the
endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and
beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3
have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective
lysosome-related organelles. Alternatively spliced transcript variants encoding the same protein have been
observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for AP3M1 Gene:
AP3M1 (adaptor-related protein complex 3, mu 1 subunit) is a protein-coding gene. An important paralog of this gene is AP4M1.

UniProtKB/Swiss-Prot: AP3M1_HUMAN, Q9Y2T2
Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is
associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles
from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1
complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and
nerve terminals

Gene Wiki entry for AP3M1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AP3M1 gene promoter:
         TBP   GR   C/EBPbeta   Spz1   GR-beta   Lmo2   POU2F1   Nkx6-1   POU2F1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAP3M1 promoter sequence
   Search Chromatin IP Primers for AP3M1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AP3M1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.2   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q22.1-q22.3

AP3M1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP3M1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M075880:  view genomic region     (about GC identifiers)

Start:
75,880,015 bp from pter      End:
75,910,826 bp from pter
Size:
30,812 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AP3M1_HUMAN, Q9Y2T2 (See protein sequence)
Recommended Name: AP-3 complex subunit mu-1  
Size: 418 amino acids; 46939 Da
Subunit: Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit
AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small
adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By
similarity)
Secondary accessions: Q5JQ12 Q9H5L2

Explore the universe of human proteins at neXtProt for AP3M1: NX_Q9Y2T2

Explore proteomics data for AP3M1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AP3M1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_036227.1  NP_996895.1  

    ENSEMBL proteins: 
     ENSP00000347408   ENSP00000361831  
    Reactome Protein details: Q9Y2T2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR018240 Clathrin_mu_CS
     IPR008968 Clathrin_mu_C
     IPR022775 AP_mu_sigma_su
     IPR011012 Longin-like_dom
     IPR028565 MHD

    Graphical View of Domain Structure for InterPro Entry Q9Y2T2

    ProtoNet protein and cluster: Q9Y2T2

    2 Blocks protein domains:
    IPB000804 Clathrin adaptor complex
    IPB001392 Clathrin adaptor complex


    UniProtKB/Swiss-Prot: AP3M1_HUMAN, Q9Y2T2
    Similarity: Belongs to the adaptor complexes medium subunit family
    Similarity: Contains 1 MHD (mu homology) domain


    Find genes that share domains with AP3M1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP3M1_HUMAN, Q9Y2T2
    Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is
    associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles
    from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1
    complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and
    nerve terminals

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19116314
         
    Find genes that share ontologies with AP3M1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AP3M1:
     Proliferating cells 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target AP3M1:
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    Block miRNA regulation of human, mouse, rat AP3M1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AP3M1 (see all 91):
    hsa-miR-579 hsa-miR-520f hsa-miR-3607-3p hsa-miR-3938 hsa-miR-1260b hsa-miR-30d hsa-miR-3653 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidAP3M1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AP3M1_HUMAN, Q9Y2T2: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side
    (By similarity). Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the
    Golgi complex (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    lysosome4
    vacuole4
    cytosol2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome TAS10024875
    GO:0005765lysosomal membrane IDA17897319
    GO:0005794Golgi apparatus IEA--
    GO:0030131clathrin adaptor complex IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--

    Find genes that share ontologies with AP3M1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AP3M1 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    3Lysosome
    Lysosome


    Find genes that share SuperPaths with AP3M1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for AP3M1
        Association of TriC/CCT with target proteins during biosynthesis


    1 Kegg Pathway  (Kegg details for AP3M1):
        Lysosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AP3M1
    Interactions:

        Search GeneGlobe Interaction Network for AP3M1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AP3M1 (Q9Y2T23 ENSP000003474084) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGOLN2O434933, ENSP000003666034I2D: score=2 STRING: ENSP00000366603
    WDR48Q8TAF33, ENSP000003074914I2D: score=2 STRING: ENSP00000307491
    AP3S2P597803, ENSP000003387774I2D: score=1 STRING: ENSP00000338777
    AQP4P550873, ENSP000003726544I2D: score=1 STRING: ENSP00000372654
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006622protein targeting to lysosome TAS10024875
    GO:0006810transport ----
    GO:0006886intracellular protein transport ----
    GO:0008089anterograde axon cargo transport ISS--
    GO:0016192vesicle-mediated transport ----

    Find genes that share ontologies with AP3M1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for AP3M1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AP3M1 gene (2 alternative transcripts): 
    NM_012095.4  NM_207012.2  

    Unigene Cluster for AP3M1:

    Adaptor-related protein complex 3, mu 1 subunit
    Hs.500104  [show with all ESTs]
    Unigene Representative Sequence: NM_207012
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355264(uc001jwf.3 uc001jwg.3 uc001jwh.3 uc010qla.2)
    ENST00000372745 ENST00000480373 ENST00000487653
    miRNA
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    hsa-miR-579 hsa-miR-520f hsa-miR-3607-3p hsa-miR-3938 hsa-miR-1260b hsa-miR-30d hsa-miR-3653 hsa-miR-877*
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      QuantiFast Probe-based Assays in human, mouse, rat AP3M1

    Additional mRNA sequence: 

    AF092092.1 AK026983.1 AK299352.1 AK315597.1 AL133610.1 AL833820.1 BC026232.1 BC067127.1 

    14 DOTS entries:

    DT.316907  DT.95265745  DT.99996973  DT.100706599  DT.40221223  DT.121269415  DT.99975996  DT.100834231 
    DT.100834232  DT.100834233  DT.102822582  DT.121269425  DT.121269428  DT.97833185 

    Selected AceView cDNA sequences (see all 290):

    BX281165 AA889470 BM984125 BM052923 BQ221519 CB123833 AU130435 BU608173 
    CR603917 AI078396 BQ001318 BX280639 CA313118 BQ670151 AA748155 BX486418 
    BP365235 AI051205 CB132715 CB141412 CB143473 AI219733 NM_012095 AA037098 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AP3M1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
    SP1:                                -     -     -                                                                       -                           
    SP2:                                -     -     -     -                                                                 -                           
    SP3:                                                  -                                                                 -                           
    SP4:                                -     -     -                                                                                                   
    SP5:                                -     -     -                                                                                                   


    ECgene alternative splicing isoforms for AP3M1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AP3M1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATAAGAAA
    AP3M1 Expression
    About this image

    AP3M1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AP3M1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500104
        Custom PCR Arrays for AP3M1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP3M1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AP3M1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ap3m11 , 5 adaptor-related protein complex 3, mu 1 subunit1, 5 92.9(n)1
    99.52(a)1
      14 (11.58 cM)5
    559461  NM_018829.41  NP_061299.31 
     210314425 
    chicken
    (Gallus gallus)
    Aves AP3M11 adaptor-related protein complex 3, mu 1 subunit 82.78(n)
    95.45(a)
      423736  NM_001031227.1  NP_001026398.1 
    lizard
    (Anolis carolinensis)
    Reptilia AP3M16
    adaptor-related protein complex 3, mu 1 subunit
    88(a)
    1 ↔ 1
    GL343196.1(2041961-2050453)
    zebrafish
    (Danio rerio)
    Actinopterygii ap3m12 adaptor-related protein complex 3, mu 1 subunit 76.48(n)   266798  AY394946.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cm3 ommochrome biosynthesis 69(a)   1 6E4   --
    worm
    (Caenorhabditis elegans)
    Secernentea apm-31 apm-3 62.88(n)
    64.25(a)
      186194  NM_075783.5  NP_508184.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APM16
    Mu1-like medium subunit of the clathrin-associated...
    23(a)
    1 → many
    XVI(51244-52671) YPL259C
    rice
    (Oryza sativa)
    Liliopsida Os.182812 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.64(n)    AK121835.1 


    ENSEMBL Gene Tree for AP3M1 (if available)
    TreeFam Gene Tree for AP3M1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AP3M1 gene
    AP4M12  AP1M22  AP3M22  AP2M12  AP1M12  
    5 SIMAP similar genes for AP3M1 using alignment to 1 protein entry:     AP3M1_HUMAN:
    DKFZp586G1518    AP3M2    AP1M2    AP1M1    AP2M1

    Find genes that share paralogs with AP3M1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AP3M1 (see all 556)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs64807171,2
    C,F,A,H--75880424(+) GTGTGT/CGCCAC 2 -- ut318Minor allele frequency- C:0.36NA WA CSA 14
    rs124160531,2
    C,F,H--75880492(+) gctggC/Tctcga 2 -- ut311Minor allele frequency- T:0.50NA 4
    rs1827016841,2
    --75880495(+) GGTCTC/TGAACT 2 -- ut310--------
    rs1869731981,2
    --75880571(+) ACGCCC/TGGCCA 2 -- ut310--------
    rs799162141,2
    C,F--75880636(+) GGGATC/GCACCA 2 -- ut311Minor allele frequency- G:0.02NA 120
    rs783547271,2
    C,F--75880653(+) TAAAAC/GAGAGT 2 -- ut311Minor allele frequency- G:0.02NA 120
    rs751459861,2
    F--75880687(+) TTCTTC/ACTTAA 2 -- ut311Minor allele frequency- A:0.01EA 120
    rs118187691,2
    C,F,H--75880727(+) GTTTTT/CAGAGT 2 -- ut316Minor allele frequency- C:0.04NS EA NA WA 542
    rs64807181,2
    C,F,A,H--75880754(+) TTTTTG/CCCTGA 2 -- ut3116Minor allele frequency- C:0.34NA WA CSA EA 522
    rs618636111,2
    C,F--75880944(+) GTCTTG/ATTTTT 2 -- ut312Minor allele frequency- A:0.03NA 122

    HapMap Linkage Disequilibrium report for AP3M1 (75880015 - 75910826 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for AP3M1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658956CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AP3M1
    DNA2.0 Custom Variant and Variant Library Synthesis for AP3M1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610366    OMIM disorders: --


    Find genes that share disorders with AP3M1           About GenesLikeMe

    Genetic Association Database (GAD): AP3M1
    Human Genome Epidemiology (HuGE) Navigator: AP3M1 (2 documents)

    Export disorders for AP3M1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AP3M1 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with AP3M1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor. (PubMed id 10024875)1, 2, 3 Dell'Angelica E.C....Bonifacino J.S. (Mol. Cell 1999)
    2. Association analysis between schizophrenia and the AP-3 complex genes. (PubMed id 19481122)1, 4 Hashimoto R....Kunugi H. (Neurosci. Res. 2009)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Structural basis for the recognition of tyrosine-based sorting signals by the I13A subunit of the AP-3 adaptor complex. (PubMed id 23404500)1 Mardones G.A....Bonifacino J.S. (J. Biol. Chem. 2013)
    7. Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. (PubMed id 23704328)1 Fatemifar G....Evans D.M. (Hum. Mol. Genet. 2013)
    8. AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway. (PubMed id 22833563)1 Dores M.R....Trejo J. (Mol. Biol. Cell 2012)
    9. Defective HIV-1 particle assembly in AP-3-deficient cells derived from patients with Hermansky-Pudlak syndrome type 2. (PubMed id 22875976)1 Liu L....Dong X. (J. Virol. 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26985 HGNC: 569 AceView: AP3M1 Ensembl:ENSG00000185009 euGenes: HUgn26985
    ECgene: AP3M1 Kegg: 26985 H-InvDB: AP3M1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AP3M1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AP3M1 gene:
    Search GeneIP for patents involving AP3M1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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