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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AP3B2 Gene

protein-coding   GIFtS: 60
GCID: GC15M083328

adaptor-related protein complex 3, beta 2 subunit
 Explore 10 diseases affiliated with
AP3B2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AP3B2    

Aliases
for AP3B2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Adaptor-Related Protein Complex 3, Beta 2 Subunit1 2     Neuron-Specific Vesicle Coat Protein Beta-NAP2 3
NAPTB1 2 5     AP-3 Complex Subunit Beta-22
Adapter-Related Protein Complex 3 Subunit Beta-22 3     Beta-3B-Adaptin1
Adaptor Protein Complex AP-3 Subunit Beta-22 3     Neuronal Adaptin-Like Protein, Beta-Subunit2
Clathrin Assembly Protein Complex 3 Beta-2 Large Chain2 3     Beta-3B-Adaptin1

External Ids:    HGNC: 5671   Entrez Gene: 81202   Ensembl: ENSG000001037237   OMIM: 6021665   UniProtKB: Q133673   

Export aliases for AP3B2 gene to outside databases

Previous GC identifers: GC15P079309 GC15M076261 GC15M080912 GC15M081053 GC15M081125 GC15M059598


Summaries
for AP3B2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AP3B2:
Adaptor protein-3 (AP3) is a heterotetrameric vesicle-coat protein complex. Some AP3 subunits are ubiquitously
expressed, whereas others are expressed exclusively in neurons. The neuron-specific AP3 complex, which includes AP3B2,
is thought to serve neuron-specific functions such as neurotransmitter release (Grabner et al., 2006 (PubMed
16788073)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: AP3B2_HUMAN, Q13367
Function: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in
protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the
recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of
transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins
targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target
cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals

Gene Wiki entry for AP3B2


Genomic Views
for AP3B2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_077661.3  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AP3B2 gene promoter:
         HFH-3   GCNF   RORalpha2   FOXL1   FOXI1   GCNF-1   ARP-1   GCNF-2   FOXO1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AP3B2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AP3B2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP3B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q

AP3B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP3B2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M083328:  view genomic region     (about GC identifiers)

Start:
 83,328,033 bp from pter      End:
 83,378,666 bp from pter
Size:
 50,634 bases      Orientation:
 minus strand

Proteins
for AP3B2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AP3B2_HUMAN, Q13367 (See protein sequence)
Recommended Name: AP-3 complex subunit beta-2  
Size: 1082 amino acids; 119059 Da
Subunit: AP-3 associates with the BLOC-1 complex (By similarity). Adaptor protein complex 3 (AP-3) is a heterotetramer
composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin
(mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2)
Subcellular location: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane
protein; Cytoplasmic side (By similarity). Golgi apparatus (By similarity). Note=Component of the coat surrounding the
cytoplasmic face of coated vesicles located at the Golgi complex (By similarity)
Developmental stage: Expressed from early in development through adulthood
Secondary accessions: A4Z4T7 O14808 Q52LY8
Alternative splicing: 2 isoforms:  Q13367-1   Q13367-2   (Relatively high levels in brain and testis)

Explore the universe of human proteins at neXtProt for AP3B2: NX_Q13367

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13367

    • AP3B2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004635.2  
    ENSEMBL proteins: 
     ENSP00000261722   ENSP00000438721   ENSP00000440984   ENSP00000445804   ENSP00000441961  
     ENSP00000440719  

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0030117membrane coat ----


    AP3B2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for AP3B2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AP3B2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR011989 ARM-like
     IPR008153 Clathrin_g-adaptin_app
     IPR002553 Clathrin/coatomer_adapt-like_N
     IPR026740 AP3_beta
     IPR026739 AP_beta

    Graphical View of Domain Structure for InterPro Entry Q13367

    ProtoNet protein and cluster: Q13367

    1 Blocks protein family: IPB002553 Adaptin

    UniProtKB/Swiss-Prot: AP3B2_HUMAN, Q13367
    Similarity: Belongs to the adaptor complexes large subunit family


    Function
    for AP3B2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AP3B2_HUMAN, Q13367
    Function: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in
    protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the
    recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of
    transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins
    targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target
    cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals

    miRNA
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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS7671305
    GO:0008565protein transporter activity ----


    AP3B2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for AP3B2:
     Increased S DNA content  Increased cell number in G2M,   S arrest 

    Animal Models:
         Mouse knock-out Ap3b2tm1Bur for AP3B2
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ap3b2):
     behavior/neurological  integument  nervous system 

    AP3B2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AP3B2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lysosome
    		Lysosome1.00
    2ATM Pathway
    		ATM Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AP3B2
        ATM Pathway


    1         Kegg Pathway  (Kegg details for AP3B2):
        Lysosome


    AP3B2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AP3B2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for AP3B2 (Q133672, 3 ENSP000002617224) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP3S1Q925723, ENSP000003253694I2D: score=1 STRING: ENSP00000325369
    ATMQ133153, ENSP000002786164I2D: score=2 STRING: ENSP00000278616
    CLTCQ006103, ENSP000002691224I2D: score=2 STRING: ENSP00000269122
    CSNK1A1P487293, ENSP000002617984I2D: score=1 STRING: ENSP00000261798
    ADAP1O756893, ENSP000002658464I2D: score=1 STRING: ENSP00000265846
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS7671305
    GO:0006897endocytosis IEA--
    GO:0008089anterograde axon cargo transport ISS--
    GO:0016192vesicle-mediated transport ----


    AP3B2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AP3B2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AP3B2
    Search CenterWatch for drugs/clinical trials and news about AP3B2 

    Transcripts
    for AP3B2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AP3B2 gene: 
    NM_004644.3  

    Unigene Cluster for AP3B2:

    Adaptor-related protein complex 3, beta 2 subunit
    Hs.199593  [show with all ESTs]
    Unigene Representative Sequence: CR749860
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261722(uc010uoh.2 uc010uoi.2 uc010uoj.2) ENST00000543938(uc010uog.2)
    ENST00000537735(uc010bmp.3) ENST00000535348 ENST00000535359 ENST00000545315
    ENST00000538592 ENST00000559888 ENST00000541693 ENST00000535385 ENST00000542200
    ENST00000561455 ENST00000535513(uc010uok.1) ENST00000560529

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF022152.1 AK097827.1 AK294331.1 BC008350.1 BC026700.1 BC093739.1 BC143342.1 BC143346.1 
    CR749860.1 DQ092369.1 U37673.1 

    11 DOTS entries:

    DT.213490  DT.100783100  DT.95234195  DT.101982366  DT.97838196  DT.100060662  DT.40109445  DT.75101081 
    DT.97807280  DT.97838195  DT.75180272 

    24/80 AceView cDNA sequences (see all 80):

    BU727978 BM724811 BI828376 AI092419 AA339232 BC026700 BQ889376 AI088084 
    BX115463 BC008350 BM718143 AI989752 BU737458 BM709392 NM_004644 AF022152 
    BQ788063 BX107950 AA723961 BM699016 BI914720 BQ271473 AW296800 CD242799 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for AP3B2 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16a ·
    SP1:              -     -     -     -     -     -     -     -     -     -     -     -     -     -                 -     -     -     -                           
    SP2:                                                                                            -                 -     -     -     -                           
    SP3:                                                                                                              -     -     -     -                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
    SP1:        -                       -                                 
    SP2:        -                       -                                 
    SP3:        -                                                         
    SP4:        -                                                         
    SP5:        -                       -                                 


    ECgene alternative splicing isoforms for AP3B2

    Expression
    for AP3B2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AP3B2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATTCCTTAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AP3B2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AP3B2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AP3B2

    SOURCE GeneReport for Unigene cluster: Hs.199593

    UniProtKB/Swiss-Prot: AP3B2_HUMAN, Q13367
    Tissue specificity: Expression is specific to nervous system. Expressed in nerve terminal and cell body, and is
    associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors
    and graded in cerebral cortex (deeper layers exhibit stronger expression)

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    In Situ
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    Orthologs
    for AP3B2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AP3B2 gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves AP3B21 adaptor-related protein complex 3, beta 2 subunit 79.22(n)
    83.78(a)    		   769343  XM_001232604.2  XP_001232605.2 
    lizard
    (Anolis carolinensis)    		 Reptilia AP3B26
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343479.1(519223-554505)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX704931.12   -- 75.22(n)    BX704931.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ap3b12 adaptor-related protein complex 3, beta 1 subunit 80.48(n)   386770  57045973 
    fruit fly
    (Drosophila melanogaster)    		 Insecta rb1 , 3 ommochrome biosynthesis3
    ruby1    		 64(a)3
    57.62(n)1
    56.76(a)1    		   1 4C73
    313811  NM_001169193.11  NP_001162664.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea apb-31 Protein APB-3 50.82(n)
    50.72(a)    		   172553  NM_059769.2  NP_492170.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PAT21 AP3-complex subunit beta-A 42.74(n)
    32.99(a)    		   824714  NM_202714.4  NP_974443.4 
    rice
    (Oryza sativa)    		 Liliopsida Os01g09733001 hypothetical protein 42.42(n)
    30.29(a)    		   4326400  NM_001052081.1  NP_001045546.1 


    ENSEMBL Gene Tree for AP3B2 (if available)
    TreeFam Gene Tree for AP3B2 (if available) 

    Paralogs
    for AP3B2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AP3B2 gene
    AP3B12  
    3 SIMAP similar genes for AP3B2 using alignment to 6 protein entries:     AP3B2_HUMAN (see all proteins):
    DKFZp686D17136    AP3B1    AP2B1

    AP3B2 for paralogs           About GeneDecksing



    Genomic Variants
    for AP3B2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/766 NCBI SNPs in AP3B2 are shown (see all 766)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1454715351,2
    		--83327565(+) CAGACC/GCCACC 2 -- int10--------
    rs1402486701,2
    		--83327571(+) CCACCC/GTAGAC 2 -- int10--------
    rs1452203401,2
    		--83327670(+) CACTAA/GGATGA 2 -- int10--------
    rs1381607911,2
    		--83327700(+) GCCAGA/GTGGGG 2 -- int10--------
    rs1146996871,2
    		F,--83327775(+) CCCCAT/CGTTAT 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1928691581,2
    		--83327811(+) AAGAAC/GAACTA 2 -- int10--------
    rs1841109071,2
    		--83327812(+) AGAAGA/TACTAA 2 -- int10--------
    rs1426614811,2
    		--83327840(+) TGAAGA/GGGACT 2 -- int10--------
    rs1447795661,2
    		--83327887(+) CTTCCA/CGCTCT 2 -- int10--------
    rs1482356061,2
    		--83327912(+) GCCCAA/GATGTC 2 -- int10--------

    HapMap Linkage Disequilibrium report for AP3B2 (83328033 - 83378666 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for AP3B2
         3 CNVs: 10488 72331 9266
         1 Indel: 11807
    Human Gene Mutation Database (HGMD): AP3B2

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    Disorders / Diseases
    for AP3B2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AP3B2 for disorders           About GeneDecksing

    OMIM gene information: 602166    OMIM disorders: --

    10 diseases for AP3B2:    About MalaCards
    neuronitis    congenital diaphragmatic hernia    cerebellar degeneration    cerebellar ataxia
    neuroectodermal tumors    cryptorchidism    hernia    ataxia
    cerebritis    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for AP3B2:
    Congenital diaphragmatic hernia
    Human Genome Epidemiology (HuGE) Navigator: AP3B2 (1 document)

    Export disorders for AP3B2 gene to outside databases

    Publications
    for AP3B2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AP3B2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with AP3B2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein. (PubMed id 7671305)1, 2, 3 Newman L.S.... Darnell R.B. (1995)
    2. Antiserum from a patient with cerebellar degeneration identifies a novel protein in Purkinje cells, cortical neurons, and neuroectodermal tumors. (PubMed id 1851215)1, 2, 3 Darnell R.B.... Posner J.B. (1991)
    3. Characterization of AP3B2_v2, a novel splice variant of human AP3B2. (PubMed id 17453999)1, 2 Chen C.... Mao Y. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. AP-3: an adaptor-like protein complex with ubiquitous expression. (PubMed id 9118953)1, 9 Dell'Angelica E.C....Bonifacino J.S. (1997)
    6. CAMOS, a nonprogressive, autosomal recessive, congeni tal cerebellar ataxia, is caused by a mutant zinc-finger protein, ZNF592. (PubMed id 20531441)1 Nicolas E....Delague V. (2010)
    7. Association analysis between schizophrenia and the AP -3 complex genes. (PubMed id 19481122)1 Hashimoto R....Kunugi H. (2009)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. HIV-1 Vpu inhibits accumulation of the envelope glycop rotein within clathrin-coated, Gag-containing endosomes. (PubMed id 18076669)1 Van Damme N. and Guatelli J. (2008)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    External Searches for AP3B2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AP3B2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8120 HGNC: 567 AceView: AP3B2 Ensembl:ENSG00000103723 euGenes: HUgn8120
    ECgene: AP3B2 Kegg: 8120 H-InvDB: AP3B2

    Other Databases showing AP3B2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AP3B2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AP3B2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AP3B2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AP3B2 gene:
    Search GeneIP for patents involving AP3B2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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