AP2S1 Gene
protein-coding GIFtS: 60
GCID: GC19M047341
|
|
adaptor-related protein complex 2, sigma 1 subunit
(Previous symbol: CLAPS2)
| |
Aliases
for AP2S1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adaptor-Related Protein Complex 2, Sigma 1 Subunit1 2 | | HA2 17 KDa Subunit2 3 | | CLAPS21 2 3 5 | | AP17-DELTA2 | | AP172 3 5 | | HHC32 | | Adaptor Protein Complex AP-2 Subunit Sigma2 3 | | AP-2 Complex Subunit Sigma2 | | Clathrin Assembly Protein 2 Small Chain2 3 | | Clathrin-Associated/Assembly/Adaptor Protein, Small 2 (17kD)2 | | Clathrin Coat Assembly Protein AP172 3 | | Sigma2-Adaptin1 | | Clathrin Coat-Associated Protein AP172 3 | | Sigma2-Adaptin1 | | Plasma Membrane Adaptor AP-2 17 KDa Protein2 3 | | Adapter-Related Protein Complex 2 Sigma Subunit3 |
Export aliases for AP2S1 gene to outside databasesPrevious GC identifers: GC19M047985 GC19M047732 GC19M052017 GC19M052033 GC19M043766 |
Summaries
for AP2S1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AP2S1:
One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasmamembrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the smallchain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: AP2S1_HUMAN, P53680Function: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transportvia Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat componentsand appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosisin which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) whichare destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itselfunable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can binddirectly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be themajor clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort themembrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synapticvesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI]endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role inmaintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha andAP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity)
Gene Wiki entry for AP2S1
|
Genomic Views
for AP2S1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AP2S1 gene promoter:
ER-alpha Sox5 CUTL1 CBF-C POU2F1 CBF-B POU2F1a CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for AP2S1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP2S1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2-q13.3 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.2-q13.3AP2S1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M047341: view genomic region
(about GC identifiers)
Start:
|
47,341,423 bp from pter |
End:
|
47,354,203 bp from pter |
Size:
|
12,781 bases |
Orientation:
|
minus strand |
|
Proteins
for AP2S1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AP2S1_HUMAN, P53680 (See
protein sequence)Recommended Name: AP-2 complex subunit sigma Size: 142 amino acids; 17018 Da
Subunit: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-typesubunit AP2S1)
Subcellular location: Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds beforeinternalization of the nascent CCV (By similarity)
Secondary accessions: B2R4Z4 O75977 Q6PK67Alternative splicing: 2 isoforms: P53680-1 P53680-2 Explore the universe of human proteins at neXtProt for AP2S1: NX_P53680
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P53680
AP2S1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004060.2 NP_067586.1
ENSEMBL proteins: ENSP00000263270 ENSP00000263271 Reactome Protein details: P53680
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
AP2S1 for ontologies About GeneDecksing
AP2S1 Antibody Products:
Assay Products for AP2S1: |
Protein
Domains /
Families
for AP2S1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AP2S1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P53680ProtoNet protein and cluster: P53680 1 Blocks protein family: IPB000804 Clathrin adaptor complex
UniProtKB/Swiss-Prot: AP2S1_HUMAN, P53680Similarity: Belongs to the adaptor complexes small subunit family |
Function
for AP2S1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AP2S1_HUMAN, P53680Function: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transportvia Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat componentsand appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosisin which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) whichare destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itselfunable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can binddirectly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be themajor clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort themembrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synapticvesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI]endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role inmaintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha andAP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP2S1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP2S1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): AP2S1 (NM_021575) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP2S1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP2S1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP2S1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
AP2S1 for ontologies About GeneDecksing
|
Pathways & Interactions
for AP2S1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Transport of MHC II:Ii complex along Golgi to TGN | | | 3 | Clathrin-dependent protein traffic | | | 4 | Degradation of CD4 | | | 5 | Signaling by FGFR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for AP2S1
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AP2S1
4  GeneGo (Thomson Reuters) Pathways for AP2S1
1  BioSystems Pathway for AP2S1
5/31 
Reactome Pathways for AP2S1 (see all 31)
3 
Kegg Pathways (Kegg details for AP2S1):
AP2S1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AP2S1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/109 Interacting proteins for AP2S1 (P536802, 3 ENSP000002632704) via UniProtKB, MINT, STRING, and/or I2D (see all 109)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
AP2S1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AP2S1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AP2S1
Search CenterWatch for drugs/clinical trials and news about AP2S1
|
Transcripts
for AP2S1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AP2S1 gene (2 alternative transcripts): NM_004069.3 NM_021575.2 Unigene Cluster for AP2S1: Adaptor-related protein complex 2, sigma 1 subunit Hs.119591 [show with all ESTs]Unigene Representative Sequence: BM8095242 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263270(uc002pft.1) ENST00000352203(uc002pfu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP2S1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP2S1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): AP2S1 (NM_021575) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP2S1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP2S1 |
Additional cDNA sequence: AJ010148.1 AJ010149.1 AK312003.1 BC006337.2 X97074.1 18 DOTS entries: DT.100653748 DT.118673 DT.91753203 DT.91753202 DT.121504845 DT.121504834 DT.121504780 DT.121504785 DT.100653750 DT.100653749 DT.100044845 DT.91753206 DT.91753211 DT.95093082 DT.95153672 DT.95153674 DT.100889484 DT.91753212 24/405 AceView cDNA sequences (see all 405): BQ054067 AA025950 CR606916 BM790437 BE646192 BM855390 AI144530 AI207776 AA358637 BQ221562 AI751728 BM704615 AA009543 BQ889006 BQ954311 BQ001225 BM704680 AJ713543 W94409 BE303066 CN480869 AL546729 BC006337 BM450844
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for AP2S1 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | · | 7g |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for AP2S1
|
Expression
for AP2S1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AP2S1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGTGGTCAC
About this image
See AP2S1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AP2S1
SOURCE GeneReport for Unigene cluster: Hs.119591
SABiosciences Custom PCR Arrays for AP2S1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP2S1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AP2S1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP2S1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP2S1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP2S1 |
Orthologs
for AP2S1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for AP2S1 gene from 9/38 species (see all 38) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
AP2S16 |
-- |
90(a) |
1 ↔ 1 |
Un(63228914-63229907) |
lizard
(Anolis carolinensis) |
Reptilia |
AP2S16 |
-- |
99(a) |
1 ↔ 1 |
GL343566.1(280988-282520) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.240432 |
Xenopus laevis transcribed sequence with strong similarity more |
84.92(n) |
|
CB197413.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.283902 |
Danio rerio cDNA clone MGC65827 IMAGE6794145, complete more |
85.35(n) |
|
BC058042.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
AP-2&sgr;3
AP-2sigma1 |
non-selective vesicle coating3
AP-2sigma1 |
91(a)3
83.8(n)1
95.77(a)1 |
|
93D23
425251 NM_142704.21 NP_650961.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
aps-21 , 3 |
Clathrin coat assembly protein3
Protein APS-21 |
93(a)3
77.7(n)1
95.07(a)1 |
|
X(4493392-4494415)3
1840911 NM_076366.41 NP_508767.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
APS2(YJR058C)4
APS21 |
Small subunit of the clathrin-associated adaptor complex more4
Aps2p1 |
55.32(n)1
50.35(a)1 |
|
10(545175-544732)4
8535211, 4 NP_012592.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G478301 |
AP-2 complex subunit sigma |
61.74(n)
61.27(a) |
|
841199 NM_103681.4 NP_175219.1 |
rice
(Oryza sativa) |
Liliopsida |
AF443601.12 |
-- |
73.5(n) |
|
AF443601.1 |
ENSEMBL Gene Tree for AP2S1 (if available)
TreeFam Gene Tree for AP2S1 (if available) |
Paralogs
for AP2S1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AP2S1 gene
- AP1S32 AP4S12 AP1S12 AP1S22
8 SIMAP similar genes for AP2S1 using alignment to 5 protein entries: AP2S1_HUMAN (see all proteins):DKFZp779P0659 AP1S1 AP1S2 AP1S3 AP4S1 AP3S1
C15orf38-AP3S2 AP3S2
AP2S1 for paralogs About GeneDecksing
|
Genomic Variants
for AP2S1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AP2S1 (47341423 - 47354203 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for AP2S1
2 CNVs: 5104 5957 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AP2S1 |
|
Disorders
/ Diseases
for AP2S1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AP2S1 for disorders About GeneDecksing
OMIM gene information: 602242
OMIM disorders: --
5  diseases for AP2S1: About MalaCardshuntington's disease cholesterol immunodeficiency malaria
neuronitis
Export disorders for AP2S1 gene to outside databases
|
Publications
for AP2S1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AP2S1 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with AP2S1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17. (PubMed id 9767099)1, 2, 3, 9 Holzmann K....Sauermann G. (1998)
- Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2-->q13.3. (PubMed id 9040778)1, 2, 3, 9 Winterpacht A.... Zabel B. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mutations in AP2S1 cause familial hypocalciuric hyperc alcemia type 3. (PubMed id 23222959)1 Nesbit M.A....Thakker R.V. (2013)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation. (PubMed id 21762802)1 Checkley M.A....Freed E.O. (2011)
|
External Searches for AP2S1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AP2S1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing AP2S1 gene
(According to HUGE)
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Specialized Databases showing AP2S1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for AP2S1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for AP2S1 gene:
Search GeneIP for patents involving AP2S1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for AP2S1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for AP2S1 | | OriGene shRNA RFP for AP2S1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AP2S1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP2S1 | | | OriGene Protein Over-expression Lysate for AP2S1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AP2S1 | | OriGene 3'-UTR Clone for AP2S1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP2S1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP2S1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for AP2S1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AP2S1 | | OriGene Custom Protein Services for AP2S1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AP2S1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AP2S1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP2S1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AP2S1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP2S1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP2S1 |
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| | | | Search Tocris compounds for AP2S1 |
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 | | | AP2S1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP2S1 |
|  |  |  | | | | Search ThermoFisher Antibodies for AP2S1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP2S1 |
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