AP2M1 Gene
protein-coding GIFtS: 67
GCID: GC03P183892
|
|
adaptor-related protein complex 2, mu 1 subunit
(Previous symbol: CLAPM1)
| |
Aliases
for AP2M1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adaptor-Related Protein Complex 2, Mu 1 Subunit1 2 | | AP-2 Mu Chain2 3 | | CLAPM11 2 3 5 | | Adaptin-Mu21 | | AP501 2 | | AP-2 Complex Subunit Mu2 | | Mu21 | | AP-2 Mu 2 Chain2 | | Adapter-Related Protein Complex 2 Mu Subunit2 3 | | Clathrin Adaptor Complex AP2, Mu Subunit2 | | Adaptor Protein Complex AP-2 Subunit Mu2 3 | | Clathrin Coat Adaptor Protein AP502 | | Clathrin Assembly Protein Complex 2 Medium Chain2 3 | | Clathrin-Associated/Assembly/Adaptor Protein, Medium 12 | | Clathrin Coat Assembly Protein AP502 3 | | Plasma Membrane Adaptor AP-2 50kDA Protein2 | | Clathrin Coat-Associated Protein AP502 3 | | Adaptin-Mu21 | | HA2 50 KDa Subunit2 3 | | KIAA01093 | | Plasma Membrane Adaptor AP-2 50 KDa Protein2 3 | | |
Export aliases for AP2M1 gene to outside databasesPrevious GC identifers: GC03M180722 GC03P184887 GC03P185294 GC03P185213 GC03P185375 GC03P181299 |
Summaries
for AP2M1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AP2M1:
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptorcomplexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which isresponsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may alsoplay an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcriptvariants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: AP2M1_HUMAN, Q96CW1Function: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transportvia transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat componentsand appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosisin which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) whichare destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itselfunable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can binddirectly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be themajor clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort themembrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synapticvesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI]endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role inmaintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 mu subunitbinds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting with to theY-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change followingphosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. The membrane-specific phosphorylationevent appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role inendocytosis of frizzled family members upon Wnt signaling (By similarity)
Gene Wiki entry for AP2M1
|
Genomic Views
for AP2M1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AP2M1 gene promoter:
E2F-3a E2F-4 E2F-5 Lmo2 E2F-2 NF-kappaB E2F E2F-1 Sox9 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for AP2M1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP2M1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q28 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q28AP2M1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P183892: view genomic region
(about GC identifiers)
Start:
|
183,892,477 bp from pter |
End:
|
183,901,879 bp from pter |
Size:
|
9,403 bases |
Orientation:
|
plus strand |
|
Proteins
for AP2M1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AP2M1_HUMAN, Q96CW1 (See
protein sequence)Recommended Name: AP-2 complex subunit mu Size: 435 amino acids; 49655 Da
Subunit: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-typesubunit AP2S1). Interacts with ATP6V1H and MEGF10. Interacts with EGFR. Interacts with F2R. Interacts with PIP5K1C;tyrosine phosphorylation of PIP5K1C weakens the interaction (By similarity). Interacts with KIAA0319; required forclathrin-mediated endocytosis of KIAA0319. Interacts with DVL2 (via DEP domain) (By similarity)
Subcellular location: Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds beforeinternalization of the nascent CCV (By similarity)
Sequence caution: Sequence=BAA09762.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from  and Proteopedia  for AP2M1:1H6E (3D)
Secondary accessions: A6NE12 D3DNT1 P20172 P53679Alternative splicing: 2 isoforms: Q96CW1-1 Q96CW1-2 Explore the universe of human proteins at neXtProt for AP2M1: NX_Q96CW1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96CW1
AP2M1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001020376.1 NP_004059.2
ENSEMBL proteins: ENSP00000371894 ENSP00000402051 ENSP00000403362 ENSP00000292807 ENSP00000402592 ENSP00000404031 ENSP00000409081 ENSP00000395438 ENSP00000404326 ENSP00000416688 Reactome Protein details: Q96CW1
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
AP2M1 for ontologies About GeneDecksing
AP2M1 Antibody Products:
Assay Products for AP2M1: |
Protein
Domains /
Families
for AP2M1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AP2M1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q96CW1ProtoNet protein and cluster: Q96CW1 1 Blocks protein family: IPB001392 Clathrin adaptor complex
UniProtKB/Swiss-Prot: AP2M1_HUMAN, Q96CW1Similarity: Belongs to the adaptor complexes medium subunit familySimilarity: Contains 1 MHD (mu homology) domain |
Function
for AP2M1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AP2M1_HUMAN, Q96CW1Function: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transportvia transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat componentsand appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosisin which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) whichare destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itselfunable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can binddirectly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be themajor clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort themembrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synapticvesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI]endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role inmaintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 mu subunitbinds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting with to theY-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change followingphosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. The membrane-specific phosphorylationevent appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role inendocytosis of frizzled family members upon Wnt signaling (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP2M1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP2M1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): AP2M1 (NM_004068) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP2M1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP2M1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP2M1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
AP2M1 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for AP2M1:
Animal Models:
Mouse knock-out Ap2m1tm1Ohno for AP2M1
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ap2m1):
AP2M1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for AP2M1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Transport of MHC II:Ii complex along Golgi to TGN | | | 3 | Clathrin-dependent protein traffic | | | 4 | Degradation of CD4 | | | 5 | Signaling by FGFR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for AP2M1
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AP2M1
1 
Cell Signaling Technology (CST) Pathway for AP2M1
5  GeneGo (Thomson Reuters) Pathways for AP2M1
2  BioSystems Pathways for AP2M1
5/38 
Reactome Pathways for AP2M1 (see all 38)
3 
Kegg Pathways (Kegg details for AP2M1):
AP2M1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AP2M1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/385 Interacting proteins for AP2M1 (Q96CW12, 3 ENSP000002928074) via UniProtKB, MINT, STRING, and/or I2D (see all 385)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RALBP1 | Q153112, 3, ENSP000000193174 | MINT-14897 MINT-14899 MINT-14898 I2D:
score=3 STRING: ENSP00000019317 | | AP2B1 | P630102, 3, ENSP000003144144 | MINT-68485 I2D:
score=6 STRING: ENSP00000314414 | | DVL2 | O146412, 3, ENSP000000053404 | MINT-66566 I2D:
score=6 STRING: ENSP00000005340 | | FXR2 | P511162, 3, ENSP000002501134 | MINT-66450 I2D:
score=5 STRING: ENSP00000250113 | | RTDR1 | Q9UHP62, 3, ENSP000002160364 | MINT-67263 I2D:
score=5 STRING: ENSP00000216036 |
About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
AP2M1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AP2M1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
AP2M1 for compounds About GeneDecksing
 Browse Tocris compounds for AP2M1
1 Novoseek chemical compound relationship for AP2M1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
26.7 |
2 |
10842319 (1), 17643423 (1) |
Search CenterWatch for drugs/clinical trials and news about AP2M1
|
Transcripts
for AP2M1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AP2M1 gene (2 alternative transcripts): NM_001025205.1 NM_004068.3 Unigene Cluster for AP2M1: Adaptor-related protein complex 2, mu 1 subunit Hs.518460 [show with all ESTs]Unigene Representative Sequence: NM_00406818/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000382456(uc003fmw.3 uc021xif.1) ENST00000484469 ENST00000427072
ENST00000487958 ENST00000411763 ENST00000292807(uc021xig.1) ENST00000448139
ENST00000466598 ENST00000460862 ENST00000455925 ENST00000439647 ENST00000432591
ENST00000472560 ENST00000431779 ENST00000490151 ENST00000468048 ENST00000461733(uc011bqy.2 uc011bqz.2)
ENST00000476434
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP2M1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP2M1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): AP2M1 (NM_004068) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP2M1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP2M1 |
Additional cDNA sequence: AK057883.1 AK294159.1 AK295999.1 AK297578.1 AK297849.1 AK300228.1 AK304510.1 AK310409.1 BC004996.1 BC013796.1 BC014030.1 BT007308.1 D63475.1 U36188.1 24/55 DOTS entries (see all 55): DT.91981465 DT.87000893 DT.91719552 DT.87004295 DT.100888346 DT.95209159 DT.95218842 DT.100888361 DT.120889651 DT.100753385 DT.100888378 DT.101973932 DT.91719730 DT.120889625 DT.95093378 DT.102836769 DT.220452 DT.100888357 DT.100888352 DT.100888354 DT.120889633 DT.101985620 DT.100888343 DT.100888353 24/1726 AceView cDNA sequences (see all 1726): BG676123 AU156051 AI081123 AI690603 CR605056 AI707821 BP377083 BF433802 BQ716486 BE621093 BP430392 CR590191 CR608244 BM995113 AW615762 CR603080 CN482573 AI366151 AA479932 BE296677 BU149315 BM695184 BM564029 BP364017
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for AP2M1 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | - | | | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | - | | | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | - | | | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | - | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | |
| ExUns: | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 |
|---|
|
| SP1: | - | | | | | | | | - | | | | - | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for AP2M1
|
Expression
for AP2M1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AP2M1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTCATCAA
About this image
See AP2M1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AP2M1
SOURCE GeneReport for Unigene cluster: Hs.518460
SABiosciences Custom PCR Arrays for AP2M1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP2M1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AP2M1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP2M1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP2M1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP2M1 |
Orthologs
for AP2M1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for AP2M1 gene from 9/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
AP2M11 |
adaptor-related protein complex 2, mu 1 subunit |
84.6(n)
99.54(a) |
|
770246 NM_001079494.1 NP_001072962.1 |
lizard
(Anolis carolinensis) |
Reptilia |
AP2M16 |
-- |
99(a) |
1 ↔ 1 |
GL343245.1(1543811-1563293) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC047969.12 |
-- |
83.6(n) |
|
BC047969.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc566432 |
similar to adaptor-related protein complex 2, mu 1 more |
84.2(n) |
|
394001 BC049515.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
AP-501 , 3 |
non-selective vesicle coating3
AP-501 |
86(a)3
76.37(n)1
87.99(a)1 |
|
426421 NM_001170215.11 NP_001163686.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
dpy-231 , 3 |
Expression: neurons, embryo, larva3
Protein DPY-231 |
80(a)3
71.11(n)1
82.07(a)1 |
|
X(4424659-4428815)3
1807131 NM_171670.31 NP_741770.11 |
A. gossypii yeast
(Ashbya gossypii) |
Saccharomycetes |
AGOS_ADR315W1 |
ADR315Wp |
50.09(n)
37.05(a) |
|
4620577 NM_209764.1 NP_984411.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G466301 |
AP-2 complex subunit mu-1 |
54.82(n)
50.12(a) |
|
834706 NM_124033.3 NP_199475.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.89292 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
74.05(n) |
|
AK102342.1 |
ENSEMBL Gene Tree for AP2M1 (if available)
TreeFam Gene Tree for AP2M1 (if available) |
Paralogs
for AP2M1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AP2M1 gene
- AP3M12 AP4M12 AP1M22 AP3M22 AP1M12
5 SIMAP similar genes for AP2M1 using alignment to 8 protein entries: AP2M1_HUMAN (see all proteins):AP1M2 AP1M1 AP4M1 AP3M2 AP3M1
AP2M1 for paralogs About GeneDecksing
|
Genomic Variants
for AP2M1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AP2M1 (183892477 - 183901879 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AP2M1
1 CNV: 4364 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AP2M1 |
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Disorders
/ Diseases
for AP2M1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AP2M1 for disorders About GeneDecksing
OMIM gene information: 601024
OMIM disorders: --
13  diseases for AP2M1: About MalaCardsnewborn respiratory distress syndrome macular degeneration dyslexia squamous cell carcinoma
huntington's disease prostate cancer ataxia cholesterol
prostatitis immunodeficiency carcinoma malaria
neuronitis
1 disease from the University of Copenhagen DISEASES database for AP2M1:Pain agnosia Human Genome Epidemiology (HuGE) Navigator: AP2M1 (2 documents)
Export disorders for AP2M1 gene to outside databases
|
Publications
for AP2M1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AP2M1 gene, integrated from 9 sources (see all 119):
(articles sorted by number of sources associating them with AP2M1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. (PubMed id 8595912)1, 3, 9 Druck T....Keen J.H. (1995)
- The dyslexia-associated protein KIAA0319 interacts wi th adaptor protein 2 and follows the classical clathrin-mediated endocytosis pa thway. (PubMed id 19419997)1, 2 Levecque C....Monaco A.P. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Clathrin-mediated endocytosis in AP-2-depleted cells. (PubMed id 12952941)1, 2 Motley A....Robinson M.S. (2003)
- Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery. (PubMed id 12032142)1, 2 Geyer M....Peterlin B.M. (2002)
- Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T- lymphocyte antigen 4 and CD28. (PubMed id 11583591)1, 2 Follows E.R.... Abbott W.M. (2001)
- Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2 Nagase T....Kotani H. (1995)
- Activity and in vitro reassembly of the coated vesicle (H+)-ATPase requires the 50-kDa subunit of the clathrin assembly complex AP-2. (PubMed id 7989329)1, 9 Liu Q....Forgac M. (1994)
- Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. (PubMed id 9256472)1, 9 Zhang Y. and Allison J.P. (1997)
- MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation. (PubMed id 17643423)2, 9 Suzuki E. and Nakayama M. (2007)
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External Searches for AP2M1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing AP2M1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing AP2M1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing AP2M1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
|
About This Section
| Patent Information for AP2M1 gene:
Search GeneIP for patents involving AP2M1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AP2M1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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