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AP2M1 Gene

protein-coding GIFtS: 66

GC03P185375

adaptor-related protein complex 2, mu 1 subunit
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CLAPM1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AP50 ^¹, ²
Adaptin-mu2 ^³
CLAPM1 ^², ³, ⁵
KIAA0109 ^³
mu2 ^¹, ²

Descriptions
AP-2 mu 2 chain ^²
AP-2 mu-2 chain ^³
Clathrin assembly protein complex 2 medium chain ^², ³
Clathrin coat assembly protein AP50 ^³
Clathrin coat-associated protein AP50 ^³
HA2 50 kDa subunit ^², ³
Plasma membrane adaptor AP-2 50 kDa protein ^³
adaptor-related protein complex 2, mu 1 subunit ^²
clathrin adaptor complex AP2, mu subunit ^²
clathrin coat adaptor protein AP50 ^²
clathrin-associated/assembly/adaptor protein, medium 1 ^²
plasma membrane adaptor AP-2 50kDA protein ^²

External Ids
HGNC: 564¹
Entrez Gene: 1173²
UniProtKB: Q96CW1³
Ensembl: ENSG00000161203⁷

Search outside databases for aliases for AP2M1 gene

Previous GC identifers: GC03M180722 GC03P184887 GC03P185294 GC03P185213

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AP2M1:

This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which

belongs to the adaptor complexes medium subunits family. The encoded protein is required for the

activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the

acidification of endosomes and lysosomes. The encoded protein may also play an important role in

regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants

encoding different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: AP2M1_HUMAN, Q96CW1

Function: Component of the adaptor complexes which link clathrin to receptors in coated vesicles.

Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of

membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma

membrane adaptor. The complex binds polyphosphoinositide-containing lipids

Gene Wiki entry for AP2M1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AP2M1 gene

Entrez Gene cytogenetic band: 3q28 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q28

AP2M1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P185375: (about GC identifiers)

Start:	185,375,328 bp from pter
End:	185,384,573 bp from pter
Size:	9,246 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AP2M1_HUMAN, Q96CW1 (See protein sequence)

Recommended Name: AP-2 complex subunit mu-1

Size: 435 amino acids; 49655 Da

Subunit: Adaptor protein complex 2 (AP-2) is an heterotetramer composed of two large adaptins

(alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit

AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with ATP6V1H and MEGF10

Subcellular location: Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic

side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma

membrane

PDB structures from and Proteopedia :

1H6E (3D)

Secondary accessions: A6NE12 P20172 P53679

Alternative splicing: 2 isoforms: Q96CW1-1 Q96CW1-2

Post-translational modifications:

Phosphorylated (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001020376.1 NP_004059.2

ENSEMBL proteins:

ENSP00000371894 ENSP00000292807

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AP2M1)
	Human Recombinant Proteins from Abnova (AP2M1)

OriGene Purified Recombinant Human Protein: AP2M1

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005778	peroxisomal membrane	EXP	17108328
GO:0005829	cytosol	EXP	2014052 11285224 16103193
GO:0005886	plasma membrane	IEA	--
GO:0030131	clathrin adaptor complex	IEA	--

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Antibodies for AP2M1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AP2M1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (AP2M1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for AP2M1

Assays for AP2M1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96CW1

ProtoNet protein and cluster: Q96CW1

1 Blocks protein family: IPB001392 Clathrin adaptor complex

UniProtKB/Swiss-Prot: AP2M1_HUMAN, Q96CW1

Similarity: Belongs to the adaptor complexes medium subunit family

Similarity: Contains 1 MHD (mu homology) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AP2M1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AP2M1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): BC014030

Applied Biosystems Silencer® siRNAs for AP2M1

Sigma-Aldrich siRNA for AP2M1

Sigma-Aldrich shRNA for AP2M1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AP2M1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001025205
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001025205
untagged cDNA clones in CMV expression vector (see all 4): BC013796

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004068

UniProtKB/Swiss-Prot: AP2M1_HUMAN, Q96CW1

Function: Component of the adaptor complexes which link clathrin to receptors in coated vesicles.

Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of

membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma

membrane adaptor. The complex binds polyphosphoinositide-containing lipids

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ap2m1):

cellular

lethality-prenatal/perinatal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	TAS	7989329 8595912
GO:0005515	protein binding	IPI	12032142
GO:0008289	lipid binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for AP2M1 (Your Favorite Gene powered by Ingenuity)

Virus Entry via Endocytic Pathways
Clathrin-mediated Endocytosis
GABA Receptor Signaling
CTLA4 Signaling in Cytotoxic T Lymphocytes

GeneDecks AP2M1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for AP2M1

5/49 Interacting proteins for AP2M1 (Q96CW1^{1, 2} ENSP00000292807³) via UniProtKB, MINT, and/or STRING (see all 49 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AP2B1	P63010², ENSP00000314414³	MINT-68485 STRING (score=.991)
NDRG1	Q92597¹	EBI-297683, EBI-716486
RALBP1	Q15311²	MINT-14897 MINT-14899 MINT-14898
DPPA2	Q7Z7J5²	MINT-67494
DVL2	O14641²	MINT-66566

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	IEA	--
GO:0016192	vesicle-mediated transport	IEA	--
GO:0050690	regulation of defense response to virus by virus	EXP	11285224 16103193

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AP2M1
1 Novoseek chemical compound relationship for AP2M1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	27.55	2	10842319 (1), 17643423 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AP2M1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AP2M1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): BC014030

Sigma-Aldrich siRNA for AP2M1

Sigma-Aldrich shRNA for AP2M1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001025205 NM_004068

REFSEQ mRNAs for AP2M1 gene (2 alternative transcripts):

NM_001025205.1 NM_004068.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001025205 NM_004068

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001025205
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001025205
                                 untagged cDNA clones in CMV expression vector (see all 4): BC013796

Additional cDNA sequence:

AK057883.1 AK294159.1 AK295999.1 AK297578.1 AK297849.1 AK300228.1 AK304510.1 AK310409.1

BC004996.1 BC013796.1 BC014030.1 BT007308.1 CR590191.1 CR590275.1 CR591964.1 CR592124.1

CR595581.1 CR597007.1 CR597271.1 CR599939.1 CR602053.1 CR603080.1 CR604155.1 CR605056.1

CR605468.1 CR606363.1 CR608244.1 CR609312.1 CR610909.1 CR615014.1 CR615224.1 CR619838.1

CR620955.1 CR621554.1 D63475.1 U36188.1

24/55 DOTS entries (see all 55 ):

DT.91981465 DT.87000893 DT.91719552 DT.87004295 DT.100888346 DT.95209159 DT.95218842 DT.100888361

DT.120889651 DT.100753385 DT.100888378 DT.101973932 DT.91719730 DT.120889625 DT.95093378 DT.102836769

DT.220452 DT.100888357 DT.100888352 DT.100888354 DT.120889633 DT.101985620 DT.100888343 DT.100888353

24/1726 AceView cDNA sequences (see all 1726 ):

BQ940289 BP362158 CN484035 BE543109 CA420943 BQ229986 AI690603 AA071323

BU179450 BM564029 BQ673932 BU944832 BF433802 BE621093 BE876563 AI081123

BM695184 CA437448 CR605468 CR590191 CA416222 BM449813 BP349087 AA341231

highest scoring ESTs for AP2M1:

D63475 AA029277 AA037083 AA057713 AA065039 AA070621 AA102613 AA181563 AA195604 AA292020

Unigene Cluster for AP2M1:

Adaptor-related protein complex 2, mu 1 subunit

Hs.518460 [show with all ESTs]

Unigene Representative Sequence: NM_004068

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for AP2M1 (see all 13 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	·	5d	·	5e	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·
SP1:													-								-				-		-								-		-		-												-
SP2:													-		-						-				-		-								-		-		-
SP3:													-								-				-		-		-						-		-		-
SP4:													-								-				-		-		-		-		-		-		-		-						-		-		-		-
SP5:																					-				-		-								-		-

ExUns:	9b	·	9c	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14
SP1:	-								-				-				-
SP2:
SP3:
SP4:	-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for AP2M1

2 Ensembl transcripts including schematic representations:

ENST00000382456 ENST00000292807

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AP2M1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AP2M1

¹ / ² / ³

3 probe-sets matching AP2M1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39795_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D63475	1.00	1.00	1.00	1
200613_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004068	0.60	1.00	0.82	1
200613_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATGTCATCAA

SOURCE GeneReport for Unigene cluster: Hs.518460
Expression variation in blood from EXPOLDB for AP2M1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AP2M1 gene from 5/23 species (see all 23 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AP2M1¹	--	adaptor-related protein complex 2, mu 1 subunit	94.18(n) 99.54(a)	607139 XM_853234.1 XP_858327.1
chimpanzee (Pan troglodytes)	AP2M1¹	--	adaptor-related protein complex 2, mu 1 subunit	99.69(n) 100(a)	736431 XM_001143289.1 XP_001143289.1
cow (Bos taurus)	AP2M1¹	--	adaptor-related protein complex 2, mu 1 subunit	93.56(n) 100(a)	517446 NM_001034523.1 NP_001029695.1
rat (Rattus norvegicus)	Ap2m1¹	--	adaptor-related protein complex 2, mu 1 subunit	92.41(n) 100(a)	116563 NM_053837.1 NP_446289.1
mouse (Mus musculus)	Ap2m1^{1, 5}	16⁵	adaptor protein complex AP-2, mu1^{1, 5}	92.64(n)¹ 100(a)¹	11773¹ NM_009679.2¹ NP_033809.1¹ AF001912⁵ AF001913⁵ (see all 31)

About this table Species with no ortholog for AP2M1

ENSEMBL Gene Tree for AP2M1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AP2M1 gene

AP3M1² AP4M1² AP3M2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/110 NCBI SNPs in AP2M1 are shown (see all 110 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 83)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1056937^1,2	C,F,H	185384262(+)	`GGGACC/TGGTGG`	2	--	ut3¹ ese³		7	MN NA EU EA	618
--	rs11539599^1,2	C,H	185379500(+)	`GGTCTT/CCGAAT`	2	S/F	mis¹ ese³		8	EU EA WA	804
--	rs16833778^1,2	F	185375244(+)	`AAATT-/GGCAAG`	2	--	ng5¹		2	MN EA	356
	rs4359840^1,2	H	185381673(-)	`CCCTGC/ATTTTC`	2	N/K	mis¹ ese³		4	EU EA WA	404
	rs4912480^1,2	H	185374771(+)	`TGGGTC/TTTGAT`	2	--	ng5¹		4	EU EA WA	418
	rs2231224^1,2	A,C,F,H	185383975(+)	`TTCGCG/ACCCTC`	2	A/A	syn¹		12	NA EU EA WA	1040
	rs8478^1,2	C,F,H	185382526(+)	`AAGATC/TGAGGT`	2	I/I	syn¹		9	MN NA EU EA WA	930
	rs13262^1,2	C,F,H	185384083(+)	`ATTTAT/CGAAAC`	2	Y/Y	syn¹		5	EU EA WA NA	484
	rs2231214^1,2	H	185377517(+)	`GAGGTG/CCTCAT`	2	V/V	syn¹		4	EU EA WA	418
	rs843369^1,2	A,C,F,H,O	185379862(-)	`AGCCAC/TCAAAC`	2	--	int¹		9	MN EU EA WA NA	814

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HapMap Linkage Disequilibrium images for AP2M1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601024

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/65 PubMed articles for AP2M1 gene (see all 65 ):

Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. (PubMed id 8595912)^{1, 2, 3} Druck T....Keen J.H. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery. (PubMed id 12032142)^{3, 4} Geyer M....Peterlin B.M. (2002)
Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T- lymphocyte antigen 4 and CD28. (PubMed id 11583591)^{3, 4} Follows E.R.... Abbott W.M. (2001)
Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)^{3, 4} Nagase T....Kotani H. (1995)
Activity and in vitro reassembly of the coated vesicle (H+)-ATPase requires the 50-kDa subunit of the clathrin assembly complex AP-2. (PubMed id 7989329)^{1, 3} Liu Q....Forgac M. (1994)
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. (PubMed id 9256472)^{1, 3} Zhang Y. and Allison J.P. (1997)
MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation. (PubMed id 17643423)^{1, 4} Suzuki E. and Nakayama M. (2007)
Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2. (PubMed id 9013859)^{1, 3} Wang X. and Kilimann M.W. (1997)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1173	HGNC: 564	AceView: AP2M1	Ensembl:ENSG00000161203	euGenes: HUgn1173
ECgene: AP2M1	H-InvDB: AP2M1

(According to HUGE)
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HUGE: KIAA0109

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AP2M1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AP2M1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AP2M1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AP2M1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AP2M1		Antibodies for AP2M1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AP2M1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AP2M1)
	Search for Antibodies
	Chimera RNAi (AP2M1)
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Antibodies for AP2M1

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AP2M1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for AP2M1

Summaries
for AP2M1

Genomic Location
for AP2M1

Proteins
for AP2M1

Protein Domains/
Families
for AP2M1

Gene Function
for AP2M1

Pathways & Interactions
for AP2M1

Drugs & Compounds
for AP2M1

Transcripts
for AP2M1

Expression
for AP2M1

Orthologs
for AP2M1

Paralogs
for AP2M1

SNPs/Variants
for AP2M1

Disorders & Mutations
for AP2M1

Medical News
for AP2M1

Publications
for AP2M1

Search for AP2M1

Genome Databases showing AP2M1

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for AP2M1

Services
for AP2M1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AP2M1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor AP2M1

Summariesfor AP2M1

Genomic Locationfor AP2M1

Proteinsfor AP2M1

Protein Domains/Familiesfor AP2M1

Gene Functionfor AP2M1

Pathways & Interactionsfor AP2M1

Drugs & Compoundsfor AP2M1

Transcriptsfor AP2M1

Expression for AP2M1

Orthologsfor AP2M1

Paralogsfor AP2M1

SNPs/Variantsfor AP2M1

Disorders & Mutationsfor AP2M1

Medical Newsfor AP2M1

Publicationsfor AP2M1

Search for AP2M1

Genome Databases showing AP2M1

Other Databases showing AP2M1

Specialized Databases showing AP2M1

Licensable Technologiesfor AP2M1

Servicesfor AP2M1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AP2M1

Summaries
for AP2M1

Genomic Location
for AP2M1

Proteins
for AP2M1

Protein Domains/
Families
for AP2M1

Gene Function
for AP2M1

Pathways & Interactions
for AP2M1

Drugs & Compounds
for AP2M1

Transcripts
for AP2M1

Expression
for AP2M1

Orthologs
for AP2M1

Paralogs
for AP2M1

SNPs/Variants
for AP2M1

Disorders & Mutations
for AP2M1

Medical News
for AP2M1

Publications
for AP2M1

Licensable Technologies
for AP2M1

Services
for AP2M1