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AP2B1 Gene

protein-coding GIFtS: 65

GC17P030938

adaptor-related protein complex 2, beta 1 subunit
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ADTB2, CLAPB1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ADTB2 ^², ³, ⁵
AP105B ^², ³
AP2-BETA ^²
Beta-adaptin ^³
Beta2-adaptin ^³
CLAPB1 ^², ³, ⁵
DKFZp781K0743 ^²

Descriptions
Adapter-related protein complex 2 beta-1 subunit ^³
Clathrin assembly protein complex 2 beta large chain ^², ³
Plasma membrane adaptor HA2/AP2 adaptin beta subunit ^², ³
adaptin, beta 2 (beta) ^²
adaptor-related protein complex 2, beta 1 subunit ^²
clathrin-associated/assembly/adaptor protein, large, beta 1 ^²

External Ids
HGNC: 563¹
Entrez Gene: 163²
UniProtKB: P63010³
Ensembl: ENSG00000006125⁷

Search outside databases for aliases for AP2B1 gene

Previous GC identifers: GC17P033684 GC17P035950 GC17P033762 GC17P034059

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AP2B1:

The protein encoded by this gene is one of two large chain components of the assembly protein

complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is

found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants

encoding different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: AP2B1_HUMAN, P63010

Function: Component of the adaptor complexes which link clathrin to receptors in coated vesicles.

Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of

membrane proteins, leading to their selection and concentration. AP2B1 is a subunit of the plasma

membrane adaptor. The complex binds polyphosphoinositides

Gene Wiki entry for AP2B1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AP2B1 gene

Entrez Gene cytogenetic band: 17q11.2-q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11.2-q12

AP2B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P030938: (about GC identifiers)

Start:	30,938,395 bp from pter
End:	31,077,549 bp from pter
Size:	139,155 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010799.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AP2B1_HUMAN, P63010 (See protein sequence)

Recommended Name: AP-2 complex subunit beta-1

Size: 937 amino acids; 104553 Da

Subunit: Adaptor protein complex 2 (AP-2) is an heterotetramer composed of two large adaptins

(alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit

AP2M1) and a small adaptin (sigma-type subunit AP2S1). Binds EPN1, EPS15, SNAP91 and clathrin

Subcellular location: Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic

side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma

membrane

PDB structures from and Proteopedia :

1E42 (3D)

2G30 (3D)

2IV8 (3D)

2IV9 (3D)

2JKR (3D)

2JKT (3D)

2VGL (3D)

Secondary accessions: A6NJP3 P21851 Q96J19

Alternative splicing: 2 isoforms: P63010-1 P63010-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001025177.1 NP_001273.1

ENSEMBL proteins:

ENSP00000314414 ENSP00000262325

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AP2B1, AP1+2 beta)
	Human Recombinant Proteins from Abnova (AP2B1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	EXP	2014052 16103193
GO:0005886	plasma membrane	IEA	--
GO:0005905	coated pit	IEA	--
GO:0030117	membrane coat	IEA	--
GO:0030131	clathrin adaptor complex	IEA	--

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Antibodies for AP2B1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for AP2B1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (AP2B1, AP1+2 beta), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for AP2B1

Assays for AP2B1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P63010

ProtoNet protein and cluster: P63010

5 Blocks protein families:

IPB000225 Armadillo repeat

IPB000357 HEAT repeat

IPB002553 Adaptin

IPB003016 2-oxo acid dehydrogenase

IPB008152 Alpha/gamma adaptin

UniProtKB/Swiss-Prot: AP2B1_HUMAN, P63010

Similarity: Belongs to the adaptor complexes large subunit family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AP2B1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AP2B1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001030006

Applied Biosystems Silencer® siRNAs for AP2B1

Sigma-Aldrich siRNA for AP2B1

Sigma-Aldrich shRNA for AP2B1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AP2B1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001030006
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001030006
untagged cDNA clones in CMV expression vector (see all 2): NM_001030006

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001030006

UniProtKB/Swiss-Prot: AP2B1_HUMAN, P63010

Function: Component of the adaptor complexes which link clathrin to receptors in coated vesicles.

Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of

membrane proteins, leading to their selection and concentration. AP2B1 is a subunit of the plasma

membrane adaptor. The complex binds polyphosphoinositides

1 MGI phenotypic allele for Ap2b1 (no phenotypes)

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12221107
GO:0008565	protein transporter activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for AP2B1 (Your Favorite Gene powered by Ingenuity)

GABA Receptor Signaling
CTLA4 Signaling in Cytotoxic T Lymphocytes
Clathrin-mediated Endocytosis
Virus Entry via Endocytic Pathways

GeneDecks AP2B1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for AP2B1

5/43 Interacting proteins for AP2B1 (ENSP00000314414³ P63010^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 43 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AP1M1	Q9BXS5²	STRING (score=.911) MINT-66499
AP1M2	Q9Y6Q5²	STRING (score=.828) MINT-68428
AP2M1	Q96CW1²	STRING (score=.991) MINT-68485
MEA1	Q16626¹^,²	EBI-432924, EBI-744921 MINT-66587 EBI-432924, EBI-744921 MINT-66587
RNPS1	Q15287¹	EBI-432924, EBI-395959

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	IEA	--
GO:0016192	vesicle-mediated transport	IEA	--
GO:0050690	regulation of defense response to virus by virus	EXP	16103193

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AP2B1
2 Novoseek chemical compound relationships for AP2B1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phenylalanine	35.17	1	10807927 (1)
tyrosine	25.06	1	10549596 (1)

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2 PharmGKB drug compound relationships for AP2B1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AP2B1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AP2B1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001030006

Sigma-Aldrich siRNA for AP2B1

Sigma-Aldrich shRNA for AP2B1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001030006 NM_001282

REFSEQ mRNAs for AP2B1 gene (2 alternative transcripts):

NM_001030006.1 NM_001282.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001030006 NM_001282

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001030006
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001030006
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001030006

Additional cDNA sequence:

AK289528.1 AK292531.1 AK295667.1 AK301522.1 AK304126.1 AY341427.1 BC006201.2 BC012150.1

CR599737.1 CR602901.1 CR749392.1 M34175.1

24/43 DOTS entries (see all 43 ):

DT.119651 DT.100725197 DT.97855409 DT.101985530 DT.100676037 DT.100676026 DT.100676035 DT.92457625

DT.91795398 DT.91902994 DT.92457619 DT.100676033 DT.120915309 DT.120915277 DT.120915349 DT.92375650

DT.100676022 DT.87016544 DT.101982283 DT.120915348 DT.75141998 DT.95171592 DT.95251367 DT.97855408

24/680 AceView cDNA sequences (see all 680 ):

NM_001282 BG913041 BU167910 AL043636 AW664002 F02072 BQ221243 AU280302

AL042042 AL538413 AU150896 M34175 BM917222 BM470787 N26565 BM699670

AI753056 BE646084 AW274728 BM473368 BU625217 BP364593 BM794788 AL708198

highest scoring ESTs for AP2B1:

M34175 AA009539 AA009805 AA062800 AA194716 AA214218 AA229079 AA234948 AA234949 AA236653

Unigene Cluster for AP2B1:

Adaptor-related protein complex 2, beta 1 subunit

Hs.514819 [show with all ESTs]

Unigene Representative Sequence: NM_001030006

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for AP2B1 (see all 9 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	·
SP1:									-		-						-								-
SP2:									-		-						-		-						-
SP3:																	-		-						-
SP4:									-		-
SP5:											-						-		-						-

ExUns:	16c	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^	27a	·	27b	·	27c
SP1:			-				-		-
SP2:			-				-
SP3:			-				-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for AP2B1

2 Ensembl transcripts including schematic representations:

ENST00000312678 ENST00000262325

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AP2B1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AP2B1

¹ / ² / ³

7 probe-sets matching AP2B1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36161_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M34175	1.00	1.00	1.00	1
200612_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001282	0.60	1.00	0.82	1
200615_s_at²^{, 3}	U133-A	4	1.00	0.87	--	--	AL567295	0.80	1.00	0.91	1
233800_at*²^{, 3}	U133-B	1	1.00	1.00	--	--	AA805082	0.20	1.00	0.72	1
200612_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200615_s_at²	U133Plus2	4	1.00	0.87	--	--	--	--	--	--	--
233800_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACTCTTCAC

SOURCE GeneReport for Unigene cluster: Hs.514819
Expression variation in blood from EXPOLDB for AP2B1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for AP2B1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AP2B1¹	--	adaptor-related protein complex 2, beta 1 subunit	94.6(n) 100(a)	480605 XM_848630.1 XP_853723.1
chimpanzee (Pan troglodytes)	AP2B1¹	--	adaptor-related protein complex 2, beta 1 subunit	99.29(n) 99.47(a)	454587 XM_001174130.1 XP_001174130.1
cow (Bos taurus)	AP2B1¹	--	adaptor-related protein complex 2, beta 1 subunit	94.36(n) 99.89(a)	282183 NM_001075125.1 NP_001068593.1
rat (Rattus norvegicus)	Ap2b1¹	--	adaptor-related protein complex 2, beta 1 subunit	92.6(n) 100(a)	140670 NM_080583.1 NP_542150.1
mouse (Mus musculus)	Ap2b1^{1, 5}	11⁵	adaptor-related protein complex 2, beta 1 subunit^{1, 5}	92.57(n)¹ 99.89(a)¹	71770¹ NM_001035854.2¹ NP_001030931.1¹ AI788979⁵ AI891777⁵ (see all 17)

About this table Species with no ortholog for AP2B1

ENSEMBL Gene Tree for AP2B1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for AP2B1 gene

AP1B1² AP4B1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/796 NCBI SNPs in AP2B1 are shown (see all 796 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 229)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs226426^1,2	A,C,F,H,O	31075289(+)	`TAGAAA/GGCATT`	2	--	ut3¹		11	NA EA MN EU WA	980
	rs9909815^1,2	A,C,F,H	31077869(+)	`GTAGCC/TGGAGC`	2	--	ng3¹		8	EU EA WA	810
--	rs9649^1,2	A,C,F,H	31075047(+)	`CCCACC/TTCTTG`	2	--	ut3¹ ese³		9	MN EU EA WA NA	930
	rs6505494^1,2	A,C,F,H	31078012(+)	`AAACCC/TGGCCT`	2	--	ng3¹		4	EU EA WA	396
	rs12604052^1,2	C,F,H	31077814(+)	`TGTCTT/CTTCCT`	2	--	ng3¹		7	EU EA WA NA	558
	rs10512473^1,2	C,F,H	31077952(+)	`CTTCTC/TATCGG`	2	--	ng3¹		12	NS EU EA WA NA	668
	rs11653803^1,2	C,F,H	31075237(+)	`TACTGT/GTTTAT`	2	--	ut3¹ ese³		8	EU EA WA	824
	rs2240903^1,2	C,F,H	31076270(-)	`TCCCCC/TAGTCT`	2	--	ut3¹ ese³		4	EU EA WA	410
	rs740913^1,2	A,C,F	31076987(-)	`GGCTGA/CGAGAA`	2	--	ut3¹ ese³		5	EA NA MN	348
	rs321618^1,2	C,F,H	30936517(-)	`TATTAC/TGATTT`	2	--	ng5¹ tfbs³		3	EU EA	296

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HapMap Linkage Disequilibrium images for AP2B1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601025

3 Novoseek disease relationships for AP2B1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cerebellar degeneration	63.93	1	7671305 (1)
ataxia telangiectasia	61.24	1	9707615 (1)
carcinoma	0.00	1	11429425 (1)

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1 PharmGKB disease relationship for AP2B1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/68 PubMed articles for AP2B1 gene (see all 68 ):

Conservation and diversity in families of coated vesicle adaptins. (PubMed id 1969413)^{1, 3, 4} Ponnambalam S.... Parham P. (1990)
The structure and function of the beta 2-adaptin appendage domain. (PubMed id 10944104)^{1, 3, 4} Owen D.J.... Evans P.R. (2000)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Molecular architecture and functional model of the endocytic AP2 complex. (PubMed id 12086608)^{3, 4} Collins B.M.... Owen D.J. (2002)
Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. (PubMed id 8595912)^{2, 3} Druck T....Keen J.H. (1995)
The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components. (PubMed id 8262066)^{2, 3} Gallusser A. and Kirchhausen T. (1993)
ATM binds to beta-adaptin in cytoplasmic vesicles. (PubMed id 9707615)^{1, 3} Lim D.-S.... Kastan M.B. (1998)
The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1. (PubMed id 12419313)^{1, 3} Cayrol C....Wright M. (2002)
beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin. (PubMed id 11777907)^{1, 3} Laporte S.A....Caron M.G. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 163	HGNC: 563	AceView: AP2B1	Ensembl:ENSG00000006125	euGenes: HUgn163
ECgene: AP2B1	H-InvDB: AP2B1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for AP2B1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AP2B1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AP2B1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AP2B1		Antibodies for AP2B1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AP2B1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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AP2B1 Gene at Home site.
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AP2B1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for AP2B1

Summaries
for AP2B1

Genomic Location
for AP2B1

Proteins
for AP2B1

Protein Domains/
Families
for AP2B1

Gene Function
for AP2B1

Pathways & Interactions
for AP2B1

Drugs & Compounds
for AP2B1

Transcripts
for AP2B1

Expression
for AP2B1

Orthologs
for AP2B1

Paralogs
for AP2B1

SNPs/Variants
for AP2B1

Disorders & Mutations
for AP2B1

Medical News
for AP2B1

Publications
for AP2B1

Search for AP2B1

Genome Databases showing AP2B1

Other Databases showing AP2B1

Specialized Databases showing AP2B1

Licensable Technologies
for AP2B1

Services
for AP2B1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AP2B1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor AP2B1

Summariesfor AP2B1

Genomic Locationfor AP2B1

Proteinsfor AP2B1

Protein Domains/Familiesfor AP2B1

Gene Functionfor AP2B1

Pathways & Interactionsfor AP2B1

Drugs & Compoundsfor AP2B1

Transcriptsfor AP2B1

Expression for AP2B1

Orthologsfor AP2B1

Paralogsfor AP2B1

SNPs/Variantsfor AP2B1

Disorders & Mutationsfor AP2B1

Medical Newsfor AP2B1

Publicationsfor AP2B1

Search for AP2B1

Genome Databases showing AP2B1

Other Databases showing AP2B1

Specialized Databases showing AP2B1

Licensable Technologiesfor AP2B1

Servicesfor AP2B1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AP2B1

Summaries
for AP2B1

Genomic Location
for AP2B1

Proteins
for AP2B1

Protein Domains/
Families
for AP2B1

Gene Function
for AP2B1

Pathways & Interactions
for AP2B1

Drugs & Compounds
for AP2B1

Transcripts
for AP2B1

Expression
for AP2B1

Orthologs
for AP2B1

Paralogs
for AP2B1

SNPs/Variants
for AP2B1

Disorders & Mutations
for AP2B1

Medical News
for AP2B1

Publications
for AP2B1

Licensable Technologies
for AP2B1

Services
for AP2B1