AP2B1 Gene
protein-coding GIFtS: 61
GCID: GC17P033914
|
|
adaptor-related protein complex 2, beta 1 subunit
(Previous symbols: ADTB2, CLAPB1)
| |
Aliases
for AP2B1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adaptor-Related Protein Complex 2, Beta 1 Subunit1 2 | | AP2-BETA2 | | ADTB21 2 3 5 | | Adaptin, Beta 2 (Beta)2 | | CLAPB11 2 3 5 | | AP-2 Complex Subunit Beta2 | | Adapter-Related Protein Complex 2 Beta Subunit2 3 | | Beta-2-Adaptin1 | | Adaptor Protein Complex AP-2 Subunit Beta2 3 | | Beta-Adaptin1 | | Clathrin Assembly Protein Complex 2 Beta Large Chain2 3 | | Clathrin-Associated/Assembly/Adaptor Protein, Large, Beta 12 | | Plasma Membrane Adaptor HA2/AP2 Adaptin Beta Subunit2 3 | | Beta-2-Adaptin1 | | AP105B2 3 | | Beta-Adaptin1 |
Export aliases for AP2B1 gene to outside databasesPrevious GC identifers: GC17P033684 GC17P035950 GC17P033762 GC17P034059 GC17P030938 GC17P030099 |
Summaries
for AP2B1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AP2B1:
The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which servesto link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coatedvesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: AP2B1_HUMAN, P63010Function: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transportvia transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat componentsand appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosisin which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) whichare destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itselfunable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can binddirectly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be themajor clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort themembrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synapticvesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI]endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role inmaintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 beta subunitacts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least someclathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least someCLASPs from AP2B1 which probably then can be positioned for further coat assembly
Gene Wiki entry for AP2B1
|
Genomic Views
for AP2B1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AP2B1 gene promoter:
AREB6 Elk-1 AML1a Brachyury ATF-2 AP-2gamma Cdc5 LCR-F1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for AP2B1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP2B1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2-q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11.2-q12AP2B1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P033914: view genomic region
(about GC identifiers)
Start:
|
33,905,065 bp from pter |
End:
|
34,053,436 bp from pter |
Size:
|
148,372 bases |
Orientation:
|
plus strand |
|
Proteins
for AP2B1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AP2B1_HUMAN, P63010 (See
protein sequence)Recommended Name: AP-2 complex subunit beta Size: 937 amino acids; 104553 Da
Subunit: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-typesubunit AP2S1). Interacts with EPN1. Interacts with EPS15; clathrin competes with EPS15. Interacts with SNAP91;clathrin competes with SNAP91. Interacts with CLTC; clathrin competes with EPS15, SNAP91 and PIP5K1C. Interacts withLDLRAP1. Interacts with AMPH and BIN1. Interacts with ARF6 (GDP-bound). Interacts (dephosphorylated at Tyr-737) withARRB1; phosphorylation of AP2B1 at Tyr-737 disrupts the interaction. Interacts with SLC2A8. Interacts with SCYL1 andSCYL2. Interacts with TGFBR1 and TGFBR2. Interacts with PIP5K1C; clathrin competes with PIP5K1C (By similarity).Interacts with DENND1B, but not with DENND1A, nor DENND1C. Interacts with FCHO1
Subcellular location: Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds beforeinternalization of the nascent CCV
6/8 PDB 3D structures from  and Proteopedia  for AP2B1 (see all 8):1E42 (3D)
2G30 (3D)
2IV8 (3D)
2IV9 (3D)
2JKR (3D)
2JKT (3D)
Secondary accessions: A6NJP3 P21851 Q96J19Alternative splicing: 2 isoforms: P63010-1 P63010-2 Explore the universe of human proteins at neXtProt for AP2B1: NX_P63010
Post-translational modifications:
Phosphorylation at Tyr-737 by SRC occurs at the plasma membrane in clathrin-coated vesicles (CCVs)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P63010
AP2B1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001025177.1 NP_001273.1
ENSEMBL proteins: ENSP00000468183 ENSP00000262325 ENSP00000468222 ENSP00000465316 ENSP00000468813 ENSP00000465848 ENSP00000314414 ENSP00000467883 ENSP00000465357 ENSP00000437413 ENSP00000467382 ENSP00000466812 ENSP00000464966 ENSP00000466580 ENSP00000440563 Reactome Protein details: P63010
Human Recombinant Protein Products for AP2B1:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
AP2B1 for ontologies About GeneDecksing
AP2B1 Antibody Products:
Assay Products for AP2B1: |
Protein
Domains /
Families
for AP2B1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AP2B1 for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry P63010ProtoNet protein and cluster: P63010 5 Blocks protein families: IPB000225 Armadillo repeat IPB000357 HEAT repeat IPB002553 Adaptin IPB003016 2-oxo acid dehydrogenase IPB008152 Alpha/gamma adaptin
UniProtKB/Swiss-Prot: AP2B1_HUMAN, P63010Similarity: Belongs to the adaptor complexes large subunit family |
Function
for AP2B1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: AP2B1_HUMAN, P63010Function: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transportvia transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat componentsand appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosisin which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) whichare destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itselfunable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can binddirectly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be themajor clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort themembrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synapticvesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI]endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role inmaintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 beta subunitacts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least someclathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least someCLASPs from AP2B1 which probably then can be positioned for further coat assembly Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
AP2B1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for AP2B1:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ap2b1):
AP2B1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP2B1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP2B1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): AP2B1 (NM_001030006) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP2B1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP2B1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP2B1 |
|
Pathways & Interactions
for AP2B1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Transport of MHC II:Ii complex along Golgi to TGN | | | 3 | Clathrin-dependent protein traffic | | | 4 | Degradation of CD4 | | | 5 | Signaling by FGFR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for AP2B1
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AP2B1
5  GeneGo (Thomson Reuters) Pathways for AP2B1
2  BioSystems Pathways for AP2B1
5/31 
Reactome Pathways for AP2B1 (see all 31)
3 
Kegg Pathways (Kegg details for AP2B1):
AP2B1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AP2B1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/195 Interacting proteins for AP2B1 (P630101, 2, 3 ENSP000003144144) via UniProtKB, MINT, STRING, and/or I2D (see all 195)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| AP1M2 | Q9Y6Q52, 3, ENSP000002502444 | MINT-68428 I2D:
score=5 STRING: ENSP00000250244 | | MLH1 | P406922, 3, ENSP000002317904 | MINT-66474 I2D:
score=5 STRING: ENSP00000231790 | | NUP54 | Q7Z3B42, 3, ENSP000002648834 | MINT-67650 I2D:
score=5 STRING: ENSP00000264883 | | THAP1 | Q9NVV92, 3, ENSP000002542504 | MINT-67315 I2D:
score=5 STRING: ENSP00000254250 | | TUBGCP4 | Q9UGJ12, 3, ENSP000002603834 | MINT-66991 I2D:
score=4 STRING: ENSP00000260383 |
About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006886 | intracellular protein transport |
IEA | -- | | GO:0007173 | epidermal growth factor receptor signaling pathway |
TAS | -- | | GO:0007268 | synaptic transmission |
TAS | -- | | GO:0007269 | neurotransmitter secretion |
-- | -- | | GO:0007411 | axon guidance |
TAS | -- |
AP2B1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AP2B1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
AP2B1 for compounds About GeneDecksing
 Browse Tocris compounds for AP2B1
2 Novoseek chemical compound relationships for AP2B1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| phenylalanine |
33.7 |
1 |
10807927 (1) |
| tyrosine |
23.3 |
1 |
10549596 (1) |
Search CenterWatch for drugs/clinical trials and news about AP2B1
|
Transcripts
for AP2B1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AP2B1 gene (2 alternative transcripts): NM_001030006.1 NM_001282.2 Unigene Cluster for AP2B1: Adaptor-related protein complex 2, beta 1 subunit Hs.514819 [show with all ESTs]Unigene Representative Sequence: NM_00103000618/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000589774 ENST00000262325(uc002hjr.3 uc002hjs.3) ENST00000592191
ENST00000592545 ENST00000590538 ENST00000591610 ENST00000312678(uc002hjq.3 uc010wci.2 uc002hjt.3 uc010ctv.3 uc010wcj.2)
ENST00000589344 ENST00000590432 ENST00000537622 ENST00000588093 ENST00000592167
ENST00000593014 ENST00000591561 ENST00000545922 ENST00000588116 ENST00000587805
ENST00000588493
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP2B1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP2B1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): AP2B1 (NM_001030006) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP2B1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP2B1 |
Additional cDNA sequence: AK289528.1 AK292531.1 AK295667.1 AK301522.1 AK304126.1 AY341427.1 BC006201.2 BC012150.1 CR749392.1 M34175.1 24/43 DOTS entries (see all 43): DT.119651 DT.100725197 DT.97855409 DT.101985530 DT.100676037 DT.100676026 DT.100676035 DT.92457625 DT.91795398 DT.91902994 DT.92457619 DT.100676033 DT.120915309 DT.120915277 DT.120915349 DT.92375650 DT.100676022 DT.87016544 DT.95251367 DT.101982283 DT.120915348 DT.95171592 DT.97855408 DT.100640903 24/680 AceView cDNA sequences (see all 680): AW274728 AL043636 AU280302 BX643620 NM_001282 AL044658 AW339005 AL041575 T82257 BU167910 CB215820 F05826 BF772812 BQ422647 BU625217 BG493230 CA446618 BP336619 BM473368 BP347590 BP345547 AL042042 BC006201 BP364295
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for AP2B1 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | · |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16c | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c |
|---|
|
| SP1: | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for AP2B1
|
Expression
for AP2B1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AP2B1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTCTTCAC
About this image
See AP2B1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AP2B1
SOURCE GeneReport for Unigene cluster: Hs.514819
SABiosciences Custom PCR Arrays for AP2B1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP2B1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AP2B1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP2B1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP2B1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP2B1 |
Orthologs
for AP2B1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for AP2B1 gene from 7/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
AP2B11 |
adaptor-related protein complex 2, beta 1 subunit |
83.07(n)
98.95(a) |
|
417525 XM_415772.3 XP_415772.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
ap2b1-prov2 |
adaptor-related protein complex 2, beta 1 subunit |
80.06(n) |
|
BC043793.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ap2b11 |
adaptor-related protein complex 2, beta 1 subunit |
79.64(n)
94.53(a) |
|
334632 NM_199919.2 NP_956213.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Bap3 |
non-selective vesicle coating |
71(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
apb-16 |
Protein APB-1, isoform c |
64(a) |
1 → many |
III(2583965-2597027) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G234606AT4G113806 |
beta-adaptin-like protein B |
59(a)57(a) |
many ↔ manymany ↔ many |
4(12243671-12248950) 4(6920489-6925969) |
rice
(Oryza sativa) |
Liliopsida |
Os.54142 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
76.5(n) |
|
AK068938.1 |
ENSEMBL Gene Tree for AP2B1 (if available)
TreeFam Gene Tree for AP2B1 (if available) |
Paralogs
for AP2B1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AP2B1 gene
- AP4B12 AP1B12
5 SIMAP similar genes for AP2B1 using alignment to 13 protein entries: AP2B1_HUMAN (see all proteins):DKFZp781K0743 AP1B1 DKFZp686A01208 AP3B2 AP4B1
AP2B1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for AP2B1
PGOHUM00000244825 PGOHUM00000261807
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Genomic Variants
for AP2B1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AP2B1 (33905065 - 34053436 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for AP2B1
3 CNVs: 102445 1963 35449
3 Indels: 10709 88431 10710 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AP2B1 |
|
Disorders
/ Diseases
for AP2B1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AP2B1 for disorders About GeneDecksing
OMIM gene information: 601025
OMIM disorders: --
15  diseases for AP2B1: About MalaCardscerebellar degeneration ataxia telangiectasia ataxia huntington's disease
hypercholesterolemia rhabdomyosarcoma alzheimer's disease adenoma
cholesterol immunodeficiency adenocarcinoma malaria
neuronitis pancreatic cancer pancreatitis
3 Novoseek disease relationships for AP2B1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cerebellar degeneration |
62.5 |
1 |
7671305 (1) |
| ataxia telangiectasia |
59.8 |
1 |
9707615 (1) |
| carcinoma |
0 |
1 |
11429425 (1) |
Export disorders for AP2B1 gene to outside databases
|
Publications
for AP2B1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AP2B1 gene, integrated from 9 sources (see all 124):
(articles sorted by number of sources associating them with AP2B1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Conservation and diversity in families of coated vesicle adaptins. (PubMed id 1969413)1, 2, 9 Ponnambalam S.... Parham P. (1990)
- beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binding site in beta 2-adaptin. (PubMed id 11777907)1, 2, 9 Laporte S.A.... Caron M.G. (2002)
- The structure and function of the beta 2-adaptin appendage domain. (PubMed id 10944104)1, 2, 9 Owen D.J.... Evans P.R. (2000)
- The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin. (PubMed id 14530274)1, 2, 9 Rappoport J.Z....Simon S.M. (2003)
- Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. (PubMed id 16903783)1, 2 Schmid E.M....McMahon H.T. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular architecture and functional model of the endocytic AP2 complex. (PubMed id 12086608)1, 2 Collins B.M.... Owen D.J. (2002)
- Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit. (PubMed id 12429842)1, 2 Yao D.... Leof E.B. (2002)
- Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. (PubMed id 8595912)1, 3 Druck T....Keen J.H. (1995)
- The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components. (PubMed id 8262066)1, 3 Gallusser A. and Kirchhausen T. (1993)
|
External Searches for AP2B1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AP2B1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AP2B1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AP2B1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AP2B1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AP2B1 gene:
Search GeneIP for patents involving AP2B1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AP2B1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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