AP2A2 Gene
protein-coding GIFtS: 61
GCID: GC11P000915
|
|
adaptor-related protein complex 2, alpha 2 subunit
(Previous symbols: CLAPA2, ADTAB)
| |
Aliases
for AP2A2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adaptor-Related Protein Complex 2, Alpha 2 Subunit1 2 | | DKFZP564D18641 | | ADTAB1 2 3 | | Adaptin, Alpha B2 | | CLAPA21 2 3 | | Alpha-Adaptin C; Huntingtin Interacting Protein J2 | | HIP91 2 3 | | Alpha2-Adaptin1 | | HYPJ1 2 3 | | AP-2 Complex Subunit Alpha-22 | | KIAA08991 3 5 | | Clathrin-Associated/Assembly/Adaptor Protein, Large, Alpha 22 | | Clathrin Assembly Protein Complex 2 Alpha-C Large Chain2 3 | | Alpha2-Adaptin1 | | Huntingtin Yeast Partner J2 3 | | Adapter-Related Protein Complex 2 Alpha-2 Subunit3 | | Huntingtin-Interacting Protein 92 3 | | Adaptor Protein Complex AP-2 Subunit Alpha-23 | | Plasma Membrane Adaptor HA2/AP2 Adaptin Alpha C Subunit2 3 | | Alpha-Adaptin C3 | | 100 KDa Coated Vesicle Protein C2 3 | | Huntingtin-Interacting Protein J3 | | HIP-92 3 | | |
Export aliases for AP2A2 gene to outside databasesPrevious GC identifers: GC11U990002 GC11M000181 GC11P000917 GC11P000741 |
Summaries
for AP2A2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AP2A2_HUMAN, O94973Function: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transportvia transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat componentsand appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosisin which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) whichare destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itselfunable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can binddirectly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be themajor clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort themembrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synapticvesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI]endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role inmaintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunitbinds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via itsC-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigmasubunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity)
Gene Wiki entry for AP2A2
|
Genomic Views
for AP2A2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AP2A2 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 MAZR POU2F2 Gfi-1 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for AP2A2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP2A2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5AP2A2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P000915: view genomic region
(about GC identifiers)
Start:
|
924,894 bp from pter |
End:
|
1,012,240 bp from pter |
Size:
|
87,347 bases |
Orientation:
|
plus strand |
|
Proteins
for AP2A2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AP2A2_HUMAN, O94973 (See
protein sequence)Recommended Name: AP-2 complex subunit alpha-2 Size: 939 amino acids; 103960 Da
Subunit: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-typesubunit AP2S1). Binds EPN1, EPS15, AMPH, SNAP91 and BIN1. Interacts with HIP1. Interacts with DGKD isoform 2 (Bysimilarity). Interacts with DENND1A, DENND1B and DENND1C (By similarity). Interacts with FCHO1 and DAB2
Subcellular location: Cell membrane (By similarity). Membrane, coated pit; Peripheral membrane protein; Cytoplasmicside (By similarity). Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites ofendocytosis seconds before internalization of the nascent CCV (By similarity)
Secondary accessions: O75403 Q53ET1 Q96SI8Alternative splicing: 3 isoforms: O94973-1 O94973-2 O94973-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for AP2A2: NX_O94973
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94973
AP2A2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001229766.1 NP_036437.1
ENSEMBL proteins: ENSP00000437228 ENSP00000436059 ENSP00000413234 ENSP00000431630 ENSP00000431786 ENSP00000433498 ENSP00000435756 ENSP00000434563 ENSP00000435863 ENSP00000434553 ENSP00000434432 ENSP00000327694 Reactome Protein details: O94973
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
AP2A2 for ontologies About GeneDecksing
AP2A2 Antibody Products:
Assay Products for AP2A2: |
Protein
Domains /
Families
for AP2A2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AP2A2 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry O94973ProtoNet protein and cluster: O94973 3 Blocks protein families: IPB002553 Adaptin IPB003164 Alpha adaptin IPB008152 Alpha/gamma adaptin
UniProtKB/Swiss-Prot: AP2A2_HUMAN, O94973Similarity: Belongs to the adaptor complexes large subunit family |
Function
for AP2A2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AP2A2_HUMAN, O94973Function: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transportvia transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat componentsand appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosisin which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) whichare destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itselfunable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can binddirectly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be themajor clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort themembrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synapticvesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI]endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role inmaintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunitbinds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via itsC-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigmasubunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP2A2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP2A2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AP2A2 (NM_012305) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP2A2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP2A2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP2A2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
AP2A2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for AP2A2:
|
Pathways & Interactions
for AP2A2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Transport of MHC II:Ii complex along Golgi to TGN | | | 3 | Clathrin-dependent protein traffic | | | 4 | Degradation of CD4 | | | 5 | Signaling by FGFR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for AP2A2
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AP2A2
4  GeneGo (Thomson Reuters) Pathways for AP2A2
1  BioSystems Pathway for AP2A2
5/31 
Reactome Pathways for AP2A2 (see all 31)
3 
Kegg Pathways (Kegg details for AP2A2):
AP2A2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AP2A2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/120 Interacting proteins for AP2A2 (O949731, 2, 3 ENSP000004132344) via UniProtKB, MINT, STRING, and/or I2D (see all 120)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
AP2A2 for ontologies About GeneDecksing
|
Drugs & Compounds
for AP2A2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AP2A2
Search CenterWatch for drugs/clinical trials and news about AP2A2
|
Transcripts
for AP2A2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AP2A2 gene (2 alternative transcripts): NM_001242837.1 NM_012305.3 Unigene Cluster for AP2A2: Adaptor-related protein complex 2, alpha 2 subunit Hs.19121 [show with all ESTs]Unigene Representative Sequence: NM_00124283718/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25): ENST00000529818 ENST00000529858 ENST00000525796 ENST00000534328 ENST00000448903(uc001lst.2 uc001lss.3)
ENST00000528815 ENST00000528195 ENST00000529125(uc009ycq.1) ENST00000531548
ENST00000534485 ENST00000527024 ENST00000526753 ENST00000530801 ENST00000524559
ENST00000527007(uc001lsu.1) ENST00000527917 ENST00000524952 ENST00000525891
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP2A2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP2A2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AP2A2 (NM_012305) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP2A2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP2A2 |
Additional cDNA sequence: AB020706.2 AF049527.1 AK001986.1 AK027640.1 AK075497.1 AK126365.1 AK223558.1 AK293763.1 AK299364.1 BC006155.1 23 DOTS entries: DT.80101671 DT.100801582 DT.95137588 DT.100819226 DT.100819227 DT.100037950 DT.95297753 DT.101973472 DT.120726319 DT.91769010 DT.100037947 DT.100802131 DT.100819231 DT.120726344 DT.95290494 DT.97771484 DT.97803553 DT.97820813 DT.97853825 DT.99946322 DT.120726311 DT.91670619 DT.95101303 24/359 AceView cDNA sequences (see all 359): BM700295 AA281673 BM769416 BU500866 AI739490 NM_012305 CB159317 BM712208 BM460393 CB140630 BQ931594 BM670774 CB132742 BC006155 BQ064623 BM818913 BM669968 BM553578 BU501891 BU074132 BM928044 BM823184 BG743132 BE382449
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for AP2A2 (see all 17) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | |
| ExUns: | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | · | 21c | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for AP2A2
|
Expression
for AP2A2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AP2A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCAGCTGC
About this image
See AP2A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AP2A2
SOURCE GeneReport for Unigene cluster: Hs.19121
SABiosciences Custom PCR Arrays for AP2A2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP2A2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AP2A2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP2A2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP2A2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP2A2 |
Orthologs
for AP2A2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for AP2A2 gene from 8/32 species (see all 32) About this table
ENSEMBL Gene Tree for AP2A2 (if available)
TreeFam Gene Tree for AP2A2 (if available) |
Paralogs
for AP2A2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AP2A2 gene
- AP2A12
5 SIMAP similar genes for AP2A2 using alignment to 10 protein entries: AP2A2_HUMAN (see all proteins):DKFZp564D1864 AP2A1 AP1G1 AP1G2 AP4E1
AP2A2 for paralogs About GeneDecksing
|
Genomic Variants
for AP2A2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AP2A2 (924894 - 1012240 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for AP2A2
4 CNVs: 29886 3831 30531 4726
2 Indels: 65834 71222 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AP2A2 |
|
Disorders
/ Diseases
for AP2A2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AP2A2 for disorders About GeneDecksing
OMIM gene information: 607242
OMIM disorders: --
5  diseases for AP2A2: About MalaCardshuntington's disease gout cholesterol immunodeficiency
malaria
1 disease from the University of Copenhagen DISEASES database for AP2A2:Wolff-Parkinson-White syndrome Export disorders for AP2A2 gene to outside databases
|
Publications
for AP2A2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AP2A2 gene, integrated from 9 sources (see all 72):
(articles sorted by number of sources associating them with AP2A2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Huntingtin interacts with a family of WW domain proteins. (PubMed id 9700202)1, 2, 3 Faber P.W....MacDonald M.E. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
- Cloning of cDNAs encoding two related 100-kD coated v esicle proteins (alpha-adaptins). (PubMed id 2564002)1, 3 Robinson M.S. (1989)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
- Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. (PubMed id 22484487)2 Umasankar P.K.... Traub L.M. (2012)
- Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (2012)
|
External Searches for AP2A2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing AP2A2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing AP2A2 gene
(According to HUGE)
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Specialized Databases showing AP2A2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for AP2A2 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for AP2A2 gene:
Search GeneIP for patents involving AP2A2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for AP2A2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AP2A2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AP2A2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP2A2 | | | OriGene Protein Over-expression Lysate for AP2A2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for AP2A2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP2A2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP2A2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AP2A2 | | OriGene Custom Protein Services for AP2A2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AP2A2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AP2A2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP2A2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AP2A2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP2A2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP2A2 |
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| | | | Search Tocris compounds for AP2A2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP2A2 |
|  |  |  | | | | ThermoFisher Antibody for AP2A2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP2A2 |
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