AP2A1 Gene
protein-coding GIFtS : 61 GCID: GC19 P050270
adaptor-related protein complex 2, alpha 1 subunit CLAPA1, ADTAA )
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Aliasesfor AP2A1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Adaptor-Related Protein Complex 2, Alpha 1 Subunit 1 2 100 KDa Coated Vesicle Protein A2 3 ADTAA1 2 3 5 AP2-ALPHA2 CLAPA11 2 3 5 Adaptin, Alpha A2 Adapter-Related Protein Complex 2 Alpha-1 Subunit2 3 Alpha1-Adaptin1 Adaptor Protein Complex AP-2 Subunit Alpha-12 3 AP-2 Complex Subunit Alpha-12 Alpha-Adaptin A2 3 Clathrin-Associated/Assembly/Adaptor Protein, Large, Alpha 12 Clathrin Assembly Protein Complex 2 Alpha-A Large Chain2 3 Alpha1-Adaptin1 Plasma Membrane Adaptor HA2/AP2 Adaptin Alpha A Subunit2 3
Export aliases for AP2A1 gene to outside databases Previous GC identifers: GC19P050928 GC19P050638 GC19P054946 GC19P054961 GC19P046646
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Summariesfor AP2A1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for AP2A1 : This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: AP2A1_HUMAN, O95782 Function : Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transportvia transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity) Gene Wiki entry for AP2A1 (Adaptor-related protein complex 2, alpha 1)
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Genomic Viewsfor AP2A1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011109.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the AP2A1 gene promoter:HOXA9 HOXA9B Pax-5 Egr-1 Olf-1 c-Ets-1 Meis-1b ARP-1 Pax-4a Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for AP2A1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3 AP2A1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P050270: view genomic region
(about GC identifiers )
Start: 50,270,180 bp from pter End:
50,310,369 bp from pter
Size: 40,190 bases Orientation:
plus strand
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Proteinsfor AP2A1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: AP2A1_HUMAN, O95782 See
protein sequence )Recommended Name: Size : 977 amino acids; 107546 DaSubunit : Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with SGIP1 (By similarity). Interacts with HIP1 and RAB11FIP2. Interacts with SLC12A5. Interacts with clathrin
Subcellular location : Cell membrane (By similarity). Membrane, coated pit; Peripheral membrane protein; Cytoplasmicside (By similarity). Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV (By similarity)
Sequence caution : Sequence=AAD15564.1; Type=Erroneous gene model prediction;Secondary accessions : Q96CI7 Q96PP6 Q96PP7 Q9H070Alternative splicing : 2 isoforms : O95782-1 O95782-2 Explore the universe of human proteins at neXtProt for AP2A1: NX_O95782 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O95782 AP2A1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_055018.2 NP_570603.2 ENSEMBL proteins: ENSP00000346246 ENSP00000351926 Reactome Protein details: O95782 Human Recombinant Protein Products for AP2A1: Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9 ): About this table
About GeneDecksing AP2A1 Antibody Products: Assay Products for AP2A1:
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Protein
Domains /for AP2A1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/10 InterPro domains/families (see all 10 ):
Graphical View of Domain Structure for InterPro Entry O95782 ProtoNet protein and cluster: O95782
3 Blocks protein families : IPB002553 IPB003164 IPB008152 UniProtKB/Swiss-Prot: AP2A1_HUMAN, O95782 Similarity : Belongs to the adaptor complexes large subunit family
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Functionfor AP2A1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: AP2A1_HUMAN, O95782 Function : Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transportvia transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity)
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for AP2A1 :1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Ap2a1) :About GeneDecksing Animal Models: Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AP2A1 (NM_130787 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP2A1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AP2A1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP2A1
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Pathways & Interactionsfor AP2A1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/21 super-pathways (see all 21 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Axon guidance 2 Transport of MHC II:Ii complex along Golgi to TGN 3 Clathrin-dependent protein traffic 4 Degradation of CD4 5 Signaling by FGFR
Pathway sources See GeneCards unified pathways Show all pathways 1 3 4 3 5/31 (see all 31 )3 (Kegg details for AP2A1) :About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AP2A1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/168 Interacting proteins for AP2A1 (O95782 2 , 3 ENSP00000351926 4 via UniProtKB, MINT, STRING , and/or I2D (see all 168 )About this table Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing
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Drugs & Compoundsfor AP2A1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for AP2A1 AP2A1
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Transcriptsfor AP2A1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for AP2A1 gene (2 alternative transcripts): NM_014203.2 NM_130787.2 Unigene Cluster for AP2A1:
Adaptor-related protein complex 2, alpha 1 subunit Hs.467125 [show with all ESTs ] Unigene Representative Sequence: NM_014203 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000354293 (uc010enj.1 uc002ppo.3 uc010enk.3 ) ENST00000359032 (uc002ppn.3 uc002ppp.1 )Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AP2A1 (NM_130787 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP2A1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AP2A1
Additional cDNA sequence: AK090661.1 AK094317.1 AK096757.1 AK124343.1 AK302005.1 AL136925.1 BC014214.2 BC111754.1
20 DOTS entries : DT.450640 DT.100697175
DT.100878220 DT.100039647 DT.97766632 DT.97795998 DT.100878221 DT.100878209 DT.95101305 DT.95296843 DT.100801367 DT.100878217 DT.100878227 DT.100878228 DT.100731895 DT.100878207 DT.100878212 DT.121499994 DT.86848069 DT.95101330 24/318 AceView cDNA sequences (see all 318 ):
BQ063673 CF125907 BU931133 CB045211 AI089828 CK819897 BQ217442 AI827964 BX342233 CA488155 CF126028 AI279375 BQ070936 BM707592 BU184981 CR595429 AW674761 BE274905 NM_014203 CD671215 AI683915 BX341226 AA031924 CB044192 GeneLoc Exon Structure
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Expression for AP2A1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section AP2A1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GACGCAGAAGAbout this image AP2A1 expression in embryonic tissues and stem cells About this table
See AP2A1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for AP2A1 SOURCE GeneReport for Unigene cluster: Hs.467125 UniProtKB/Swiss-Prot: AP2A1_HUMAN, O95782 Tissue specificity : Isoform A expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heartand colon. Isoform B is widely expressed in tissues and also in breast cancer and in prostate carcinoma cells SABiosciences Custom PCR Arrays for AP2A1 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP2A1
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Orthologsfor AP2A1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for AP2A1 gene from 7/26 species (see all 26 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Ap2a11 5
adaptor protein complex AP-2, alpha 1 subunit5 1
90.22(n) 1 98.53(a) 1
7 (29.01 cM) 5 11771 1 NM_007458.2 1 NP_031484.1 1 44900373 5
lizard Reptilia AP2A16
--
89(a)
1 ↔ 1
6(80196262-80233542)
zebrafish Actinopterygii CR936975.26
--
85(a)
1 ↔ 1
3(32503428-32536625)
fruit fly Insecta alpha-Adaptin3
non-selective vesicle coating
78(a)
21C4 --
worm Secernentea apa-26
AdaPtin, Alpha chain (clathrin associated complex)... 64(a)
1 → many
X(9336760-9342892)
thale cress eudicotyledons alpha-ADR6 6
AP-2 complex subunit alpha-2
34(a) 34(a)
many ↔ manymany ↔ many
5(7579263-7588249) 5(7589854-7598049)
rice Liliopsida --
adapitin protein, putative, expressed
35(a)
1 → many
3(697191-707686)
ENSEMBL Gene Tree for AP2A1 (if available)TreeFam Gene Tree for AP2A1 (if available)
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Paralogsfor AP2A1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for AP2A1 gene AP2A2 2 1 SIMAP similar gene for AP2A1 using alignment to 2 protein entries: AP2A1_HUMAN (see all proteins ):AP2A2 About GeneDecksing
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Genomic Variantsfor AP2A1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 19 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for AP2A1 (50270180 - 50310369 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for AP2A1 4 CNVs 78227 89283 5114 32261
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor AP2A1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 601026
OMIM disorders : --16 : About MalaCards teratocarcinoma seminoma huntington's disease myeloid leukemia gout pancreatic cancer prostate carcinoma breast cancer pancreatitis leukemia cholesterol prostatitis immunodeficiency carcinoma malaria neuronitis 1 disease from the University of Copenhagen DISEASES database for AP2A1 :Teratocarcinoma Export disorders for AP2A1 gene to outside databases
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Publicationsfor AP2A1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for AP2A1 gene, integrated from 9 sources (see all 87 ):(articles sorted by number of sources associating them with AP2A1) Utopia : connect your pdf to the dynamic
The huntingtin interacting protein HIP1 is a clathrin and alpha- adaptin-binding protein involved in receptor-mediated endocytosis. (PubMed id 11532990) 1 , 2 , 9(2001) The DNA sequence and biology of human chromosome 19. (PubMed id 15057824) 1 , 2 (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene. (PubMed id 12036598) 1 , 2 (2002) Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors. (PubMed id 12364336) 1 , 2 (2002) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 , 2 (2001) Cloning of cDNAs encoding two related 100-kD coated v esicle proteins (alpha-adaptins). (PubMed id 2564002) 1 , 3(1989) Inhibitory function of adapter-related protein complex 2 alpha 1 subunit in the process of nuclear translocation of human immunodeficiency virus type 1 genome. (PubMed id 18178234) 1 , 9(2008) A census of human soluble protein complexes. (PubMed id 22939629) 1 (2012) Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844) 1 (2012)
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External Searches for AP2A1 gene
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Genome Databases showing AP2A1 gene
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Specialized Databases showing AP2A1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for AP2A1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for AP2A1 gene: AP2A1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor AP2A1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits Browse OriGene siRNAs OriGene 3'-UTR Clone for AP2A1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for AP2A1 OriGene Custom Protein Services for AP2A1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AP2A1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for AP2A1
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP2A1
ThermoFisher Antibody for AP2A1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AP2A1
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BioSystems Pathways for AP2A1 
Kegg Pathways 
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Microarrays
In-situ hybridization
