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AP1S3 Gene

protein-coding   GIFtS: 50
GCID: GC02M224616

Adaptor-Related Protein Complex 1, Sigma 3 Subunit

  See AP1S3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adaptor-Related Protein Complex 1, Sigma 3 Subunit1 2     Adaptor Protein Complex AP-1 Sigma-1C Subunit2
Adapter-Related Protein Complex 1 Subunit Sigma-1C2 3     AP-1 Complex Subunit Sigma-32
Clathrin Assembly Protein Complex 1 Sigma-1C Small Chain2 3     Sigma1C-adaptin3
Golgi Adaptor HA1/AP1 Adaptin Sigma-1C Subunit2 3     Adaptor Protein Complex AP-1 Subunit Sigma-1C3
Sigma 1C Subunit Of AP-1 Clathrin2 3     Sigma-Adaptin 1C3

External Ids:    HGNC: 189711   Entrez Gene: 1303402   Ensembl: ENSG000001520567   UniProtKB: Q96PC33   

Export aliases for AP1S3 gene to outside databases

Previous GC identifers: GC02M222638 GC02M223342 GC02M224580 GC02M224824 GC02M224447 GC02M224325 GC02M216442


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AP1S3 Gene:
This gene encodes a member of the adaptor-related protein complex 1, sigma subunit genes. The encoded protein is a
component of adaptor protein complex 1 (AP-1), one of the AP complexes involved in claathrin-mediated vesicular
transport from the Golgi or endosomes. Disruption of the pathway for display of HIV-1 antigens, which prevents
recognition of the virus by cytotoxic T cells, has been shown to involve the AP-1 complex (PMID: 15569716).
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Mar 2014)

GeneCards Summary for AP1S3 Gene:
AP1S3 (adaptor-related protein complex 1, sigma 3 subunit) is a protein-coding gene. Diseases associated with AP1S3 include generalized pustular psoriasis, and pustulosis palmaris et plantaris. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is AP4S1.

UniProtKB/Swiss-Prot: AP1S3_HUMAN, Q96PC3
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the
late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin
to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the AP1S3 gene promoter:
         HSF1 (long)   Evi-1   Arnt   Meis-1b   Max   HSF1short   Meis-1a   LyF-1   Meis-1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for AP1S3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AP1S3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q36.3

AP1S3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP1S3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M224616:  view genomic region     (about GC identifiers)

Start:
224,616,403 bp from pter      End:
224,702,744 bp from pter
Size:
86,342 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AP1S3_HUMAN, Q96PC3 (See protein sequence)
Recommended Name: AP-1 complex subunit sigma-3  
Size: 154 amino acids; 18280 Da
Subunit: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit
AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin
(sigma-type subunit AP1S1 or AP1S2 or AP1S3)
1 PDB 3D structure from and Proteopedia for AP1S3:
4HMY (3D)    
Secondary accessions: B4DQZ1 Q8WTY1 Q96DD1
Alternative splicing: 4 isoforms:  Q96PC3-1   Q96PC3-2   Q96PC3-4   Q96PC3-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for AP1S3: NX_Q96PC3

Explore proteomics data for AP1S3 at MOPED


See AP1S3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001034658.1  
ENSEMBL proteins: 
 ENSP00000397155   ENSP00000401705   ENSP00000333888   ENSP00000379891   ENSP00000379890  
 ENSP00000388738   ENSP00000399738   ENSP00000387199   ENSP00000406686  
Reactome Protein details: Q96PC3

AP1S3 Human Recombinant Protein Products:

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antibodies-online proteins for AP1S3 (2 products) 

 
antibodies-online peptides for AP1S3

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antibodies-online antibodies for AP1S3 (15 products) 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR000804 Clathrin_sm-chain_CS
 IPR022775 AP_mu_sigma_su
 IPR016635 AP_complex_ssu
 IPR011012 Longin-like_dom

Graphical View of Domain Structure for InterPro Entry Q96PC3

ProtoNet protein and cluster: Q96PC3

1 Blocks protein domain: IPB000804 Clathrin adaptor complex

UniProtKB/Swiss-Prot: AP1S3_HUMAN, Q96PC3
Similarity: Belongs to the adaptor complexes small subunit family


Find genes that share domains with AP1S3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: AP1S3_HUMAN, Q96PC3
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the
late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin
to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008565protein transporter activity IEA--
     
Find genes that share ontologies with AP1S3           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for AP1S3

miRNA
Products:
    
miRTarBase miRNAs that target AP1S3:
hsa-mir-1 (MIRT023729), hsa-mir-101-3p (MIRT027290)

Block miRNA regulation of human, mouse, rat AP1S3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate AP1S3 (see all 76):
hsa-miR-548j hsa-miR-607 hsa-miR-376b hsa-miR-188-5p hsa-miR-15a hsa-miR-4272 hsa-miR-548a-5p hsa-miR-761
Browse SwitchGear 3'UTR luciferase reporter plasmids
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
AP1S3_HUMAN, Q96PC3: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic
side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated
vesicles located at the Golgi complex
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
golgi apparatus5
cytosol4
lysosome4
vacuole4
endoplasmic reticulum1
mitochondrion1
nucleus1
peroxisome1

Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000139Golgi membrane TAS--
GO:0005765lysosomal membrane TAS--
GO:0005829cytosol TAS--
GO:0005905coated pit IEA--
GO:0016020membrane ----

Find genes that share ontologies with AP1S3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for AP1S3 About   (see all 9)  
See pathways by source

SuperPathContained pathways About
1Clathrin dependent protein traffic
Clathrin dependent protein traffic0.66
Transport Clathrin coated vesicle cycle0.66
2Clathrin derived vesicle budding
Clathrin derived vesicle budding0.89
Lysosome Vesicle Biogenesis0.41
Golgi Associated Vesicle Biogenesis0.89
Membrane Trafficking0.32
trans-Golgi Network Vesicle Budding0.89
3Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters0.76
Nef mediated downregulation of MHC class I complex cell surface expression0.00
The role of Nef in HIV-1 replication and disease pathogenesis0.76
4HIV Life Cycle
HIV Infection0.62
Host Interactions of HIV factors0.60
5Class I MHC mediated antigen processing and presentation
Adaptive Immune System0.41


Find genes that share SuperPaths with AP1S3           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AP1S3
    CTLA4 Signaling

1 GeneGo (Thomson Reuters) Pathway for AP1S3
    Transport Clathrin-coated vesicle cycle

4 Reactome Pathways for AP1S3
    Golgi Associated Vesicle Biogenesis
Lysosome Vesicle Biogenesis
Nef mediated downregulation of MHC class I complex cell surface expression
MHC class II antigen presentation


1 Kegg Pathway  (Kegg details for AP1S3):
    Lysosome

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AP1S3
Interactions:

    Search GeneGlobe Interaction Network for AP1S3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for AP1S3 (ENSP000003798914) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
InteractantInteraction Details
GeneCardExternal ID(s)
AP1M1ENSP000003889964STRING: ENSP00000388996
AP1M2ENSP000002502444STRING: ENSP00000250244
AP1G1ENSP000003771484STRING: ENSP00000377148
AP1S1ENSP000003366664STRING: ENSP00000336666
AP1S2ENSP000003287894STRING: ENSP00000328789
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Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006810transport ----
GO:0006886intracellular protein transport IEA--
GO:0006892post-Golgi vesicle-mediated transport TAS--
GO:0015031protein transport ----
GO:0016032viral process TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for AP1S3



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for AP1S3 gene (2 alternative transcripts): 
NM_001039569.1  NM_178814.2  

Unigene Cluster for AP1S3:

Adaptor-related protein complex 1, sigma 3 subunit
Hs.632555  [show with all ESTs]
Unigene Representative Sequence: NM_001039569
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000443700(uc010fwx.2) ENST00000415298(uc002vnn.3 uc010fww.3 uc002vno.3)
ENST00000334271 ENST00000396654 ENST00000396653 ENST00000446015 ENST00000444408
ENST00000409375 ENST00000423110
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate AP1S3 (see all 76):
hsa-miR-548j hsa-miR-607 hsa-miR-376b hsa-miR-188-5p hsa-miR-15a hsa-miR-4272 hsa-miR-548a-5p hsa-miR-761
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat AP1S3
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP1S3
Addgene plasmids for AP1S3 
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for AP1S3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AP1S3
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  QuantiFast Probe-based Assays in human, mouse, rat AP1S3

Additional mRNA sequence: 

AF393369.1 AK025338.1 AK299026.1 BC009606.1 

7 DOTS entries:

DT.431476  DT.100754576  DT.40208975  DT.120940301  DT.40125328  DT.91836091  DT.95150414 

Selected AceView cDNA sequences (see all 276):

AF393369 AU134546 AA242945 BM786152 CA398252 BP364649 BX115673 BG759326 
AA721432 CB160619 BG777963 AW243572 AF411977 BG177582 BQ887960 AA411290 
AK023415 BF447259 CB161324 BF223120 AA450337 BM470844 BM692877 CB113572 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for AP1S3    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8
SP1:                                -           -                       -         
SP2:                                -                                             
SP3:        -     -     -                 -     -                                 
SP4:                                -           -                                 
SP5:                                -     -     -                                 


ECgene alternative splicing isoforms for AP1S3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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AP1S3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
AP1S3 Expression
About this image


AP1S3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Kidney (Urinary System)    fully expand to see all 3 entries
         Ureteric Bud Cells Ureteric Bud
         Ureteric Bud
 
 Umbilical Cord (Extraembryonic Tissues)
         Wharton's jelly-derived stem cells
 
 Adipose (Muscoskeletal System)
         Body Subcutaneous White Adipose
 
 Epiblast (Early Embryonic Tissues)
         Epiblast Stem Cell line 5
AP1S3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

AP1S3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.632555

UniProtKB/Swiss-Prot: AP1S3_HUMAN, Q96PC3
Tissue specificity: Widely expressed

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1S3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for AP1S3 gene from Selected species (see all 18)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ap1s31 , 5 adaptor-related protein complex AP-1, sigma 31, 5 90.48(n)1
95.45(a)1
  1 (40.92 cM)5
2529031  NM_183027.21  NP_898848.11 
 796068765 
chicken
(Gallus gallus)
Aves AP1S31 adaptor-related protein complex 1, sigma 3 subunit 81.82(n)
87.66(a)
  424807  NM_001030008.1  NP_001025179.1 
lizard
(Anolis carolinensis)
Reptilia AP1S36
adaptor-related protein complex 1, sigma 3 subunit...
85(a)
1 ↔ 1
3(25066806-25106274)
African clawed frog
(Xenopus laevis)
Amphibia Xl.165052 Xenopus laevis transcribed sequence with moderate similarity more 76.89(n)    BJ628220.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.10842 Transcribed sequence with moderate similarity to protein more 78.05(n)    BM184887.1 
fruit fly
(Drosophila melanogaster)
Insecta AP-1sigma6
AP-1sigma
69(a)
1 → many
3R(19784376-19788277)
worm
(Caenorhabditis elegans)
Secernentea aps-16
Protein APS-1 (aps-1) mRNA, complete cds
64(a)
1 → many
V(6017970-6018884) WBGene00000159
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APS16
Small subunit of the clathrin-associated adaptor c...
45(a)
1 → many
XII(500579-501049) YLR170C
rice
(Oryza sativa)
Liliopsida Os03g08113001 Os03g0811300 59.18(n)
58.5(a)
  4334539  NM_001058205.1  NP_001051670.1 


ENSEMBL Gene Tree for AP1S3 (if available)
TreeFam Gene Tree for AP1S3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for AP1S3 gene
AP4S12  AP2S12  AP1S12  AP1S22  
9 SIMAP similar genes for AP1S3 using alignment to 7 protein entries:     AP1S3_HUMAN (see all proteins):
DKFZp779P0659    AP1S1    AP1S2    LIN7B    AP2S1    AP4S1
C15orf38-AP3S2    AP3S2    AP3S1

Find genes that share paralogs with AP1S3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for AP1S3 (see all 1925)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1398102451,2
--224619554(+) CCAGAA/GGTGGA 1 -- int10--------
rs1915380521,2
--224619806(+) AATTAC/TGTGTA 1 -- int10--------
rs1162586211,2
--224619986(+) AGTAGC/TAATTT 1 -- int10--------
rs354285411,2
C--224620011(+) GACTT-/AAAAAA 1 -- int10--------
rs30994671,2
C,F,O,A,H--224620181(-) ATCTTA/CCATGG 1 -- ut3116Minor allele frequency- C:0.30NS EA NA WA 1206
rs1833665731,2
--224620210(+) ATTTAC/TCCCAC 1 -- ut310--------
rs1872614971,2
--224620215(+) CCCCAC/TTGTGC 1 -- ut310--------
rs121513801,2
C,F,H--224620222(+) GTGCCA/GTATAG 1 -- ut3119Minor allele frequency- G:0.08NS EA NA WA 2242
rs126946201,2
C,A--224620290(+) TCACCT/CGGGCT 1 -- ut312Minor allele frequency- C:0.25NA 4
rs1921025671,2
--224620303(+) AGTACA/TGTGGC 1 -- ut310--------

HapMap Linkage Disequilibrium report for AP1S3 (224616403 - 224702744 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for AP1S3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv3183CNV Insertion18451855
nsv834554CNV Loss17160897
nsv834555CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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4 diseases for AP1S3:    
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generalized pustular psoriasis    pustulosis palmaris et plantaris    acrodermatitis continua suppurativa of hallopeau    hiv-1


Find genes that share disorders with AP1S3           About GenesLikeMe

Genetic Association Database (GAD): AP1S3
Human Genome Epidemiology (HuGE) Navigator: AP1S3 (1 document)

Export disorders for AP1S3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for AP1S3 gene, integrated from 10 sources (see all 22):
(articles sorted by number of sources associating them with AP1S3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Adaptins: the final recount. (PubMed id 11598180)1, 2 Boehm M. and Bonifacino J.S. (Mol. Biol. Cell 2001)
  4. Replication of Caucasian loci associated with bone mineral density in Koreans. (PubMed id 23575750)1 Kim Y.A....Cho N.H. (Osteoporos Int 2013)
  5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
  6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  7. HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment. (PubMed id 16253302)1 Coleman S.H....Guatelli J.C. (Virology 2006)
  8. Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes. (PubMed id 15681409)1 Coleman S.H....Guatelli J.C. (J. Virol. 2005)
  9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
  10. HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail. (PubMed id 15569716)1 Roeth J.F....Collins K.L. (J. Cell Biol. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 130340 HGNC: 18971 AceView: WDFY1andAP1S3 Ensembl:ENSG00000152056 euGenes: HUgn130340
ECgene: AP1S3 Kegg: 130340 H-InvDB: AP1S3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for AP1S3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for AP1S3 gene:
Search GeneIP for patents involving AP1S3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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