Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AP1M2 Gene

Aliases for AP1M2 Gene

  • Adaptor-Related Protein Complex 1, Mu 2 Subunit 2 3
  • Clathrin Assembly Protein Complex 1 Mu-2 Medium Chain 2 3 4
  • Golgi Adaptor HA1/AP1 Adaptin Mu-2 Subunit 3 4
  • AP-Mu Chain Family Member Mu1B 3 4
  • Mu-Adaptin 2 3 4
  • Mu1B-Adaptin 3 4
  • MU1B 3 6
  • Adaptor-Related Protein Complex 1 Subunit Mu-2 4
  • Clathrin-Associated Adaptor Medium Chain Mu2 3
  • Adaptor Protein Complex AP-1 Mu-2 Subunit 3
  • Adaptor Protein Complex AP-1 Subunit Mu-2 4
  • Clathrin Coat Associated Protein AP47 2 3
  • Clathrin Coat Assembly Protein AP47 2 3
  • Golgi Adaptor AP-1 47 KDa Protein 3
  • AP-1 Complex Subunit Mu-2 3
  • HA1 47 KDa Subunit 2 3
  • AP1-Mu2 3
  • HSMU1B 3
  • MU-1B 3
  • Mu2 3

External Ids for AP1M2 Gene

Previous GeneCards Identifiers for AP1M2 Gene

  • GC19M010814
  • GC19M010906
  • GC19M010528
  • GC19M010544
  • GC19M010683
  • GC19M010261

Summaries for AP1M2 Gene

Entrez Gene Summary for AP1M2 Gene

  • This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for AP1M2 Gene

AP1M2 (Adaptor-Related Protein Complex 1, Mu 2 Subunit) is a Protein Coding gene. Among its related pathways are Disease and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is AP4M1.

UniProtKB/Swiss-Prot for AP1M2 Gene

  • Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

Gene Wiki entry for AP1M2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP1M2 Gene

Genomics for AP1M2 Gene

Regulatory Elements for AP1M2 Gene

Genomic Location for AP1M2 Gene

Start:
10,572,671 bp from pter
End:
10,587,315 bp from pter
Size:
14,645 bases
Orientation:
Minus strand

Genomic View for AP1M2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AP1M2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP1M2 Gene

Proteins for AP1M2 Gene

  • Protein details for AP1M2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6Q5-AP1M2_HUMAN
    Recommended name:
    AP-1 complex subunit mu-2
    Protein Accession:
    Q9Y6Q5
    Secondary Accessions:
    • B2RDV5
    • Q9BSI8

    Protein attributes for AP1M2 Gene

    Size:
    423 amino acids
    Molecular mass:
    48108 Da
    Quaternary structure:
    • Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3)

    Alternative splice isoforms for AP1M2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP1M2 Gene

Proteomics data for AP1M2 Gene at MOPED

Post-translational modifications for AP1M2 Gene

  • Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.
  • Ubiquitination at Lys237 and Lys400
  • Modification sites at PhosphoSitePlus

Other Protein References for AP1M2 Gene

No data available for DME Specific Peptides for AP1M2 Gene

Domains for AP1M2 Gene

Suggested Antigen Peptide Sequences for AP1M2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6Q5

UniProtKB/Swiss-Prot:

AP1M2_HUMAN :
  • Q9Y6Q5
Domain:
  • Contains 1 MHD (mu homology) domain.
Family:
  • Belongs to the adaptor complexes medium subunit family.
genes like me logo Genes that share domains with AP1M2: view

No data available for Gene Families for AP1M2 Gene

Function for AP1M2 Gene

Molecular function for AP1M2 Gene

UniProtKB/Swiss-Prot Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

Gene Ontology (GO) - Molecular Function for AP1M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with AP1M2: view

Phenotypes for AP1M2 Gene

genes like me logo Genes that share phenotypes with AP1M2: view

Animal Model Products

CRISPR Products

miRNA for AP1M2 Gene

miRTarBase miRNAs that target AP1M2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AP1M2 Gene

Localization for AP1M2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1M2 Gene

Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AP1M2 Gene COMPARTMENTS Subcellular localization image for AP1M2 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
lysosome 4
vacuole 4
endosome 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AP1M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005765 lysosomal membrane TAS --
GO:0005829 cytosol TAS --
GO:0030131 clathrin adaptor complex IEA --
GO:0030659 cytoplasmic vesicle membrane TAS --
genes like me logo Genes that share ontologies with AP1M2: view

Pathways for AP1M2 Gene

genes like me logo Genes that share pathways with AP1M2: view

Pathways by source for AP1M2 Gene

1 KEGG pathway for AP1M2 Gene
1 GeneGo (Thomson Reuters) pathway for AP1M2 Gene

Gene Ontology (GO) - Biological Process for AP1M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting TAS 10338135
GO:0006810 transport --
GO:0006886 intracellular protein transport --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0006903 vesicle targeting TAS 10338135
genes like me logo Genes that share ontologies with AP1M2: view

Transcripts for AP1M2 Gene

Unigene Clusters for AP1M2 Gene

Adaptor-related protein complex 1, mu 2 subunit:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AP1M2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AP1M2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1:
SP2:
SP3:
SP4: -

Relevant External Links for AP1M2 Gene

GeneLoc Exon Structure for
AP1M2
ECgene alternative splicing isoforms for
AP1M2

Expression for AP1M2 Gene

mRNA expression in normal human tissues for AP1M2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AP1M2 Gene

This gene is overexpressed in Colon - Transverse (5.8), Esophagus - Mucosa (4.5), Kidney - Cortex (4.2), and Pancreas (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AP1M2 Gene

SOURCE GeneReport for Unigene cluster for AP1M2 Gene Hs.18894

genes like me logo Genes that share expressions with AP1M2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AP1M2 Gene

Orthologs for AP1M2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AP1M2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP1M2 35
  • 99.68 (n)
  • 99.53 (a)
AP1M2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AP1M2 35
  • 90.78 (n)
  • 96.69 (a)
AP1M2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AP1M2 35
  • 90.61 (n)
  • 96.84 (a)
AP1M2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap1m2 35
  • 87 (n)
  • 96.93 (a)
Ap1m2 16
Ap1m2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AP1M2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AP1M2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ap1m2 35
  • 87.94 (n)
  • 97.16 (a)
chicken
(Gallus gallus)
Aves AP1M2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AP1M2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ap1m2 35
  • 78.25 (n)
  • 89.83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9527 35
zebrafish
(Danio rerio)
Actinopterygii ap1m2 35
  • 77.3 (n)
  • 82.74 (a)
ap1m2 36
  • 83 (a)
OneToOne
Dr.20705 35
fruit fly
(Drosophila melanogaster)
Insecta AP-47 36
  • 75 (a)
OneToMany
AP-47 37
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea apm-1 35
  • 60.25 (n)
  • 69.83 (a)
apm-1 36
  • 69 (a)
ManyToMany
unc-101 36
  • 70 (a)
ManyToMany
apm-1 37
  • 69 (a)
unc-101 37
  • 70 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APM1 36
  • 49 (a)
OneToMany
APM2 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10081 35
soybean
(Glycine max)
eudicotyledons Gma.3839 35
barley
(Hordeum vulgare)
Liliopsida Hv.6301 35
corn
(Zea mays)
Liliopsida Zm.14288 35
rice
(Oryza sativa)
Liliopsida Os.38379 35
wheat
(Triticum aestivum)
Liliopsida Ta.8549 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2288 36
  • 72 (a)
OneToMany
Species with no ortholog for AP1M2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for AP1M2 Gene

ENSEMBL:
Gene Tree for AP1M2 (if available)
TreeFam:
Gene Tree for AP1M2 (if available)

Paralogs for AP1M2 Gene

Paralogs for AP1M2 Gene

Selected SIMAP similar genes for AP1M2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for AP1M2 Gene

genes like me logo Genes that share paralogs with AP1M2: view

Variants for AP1M2 Gene

Sequence variations from dbSNP and Humsavar for AP1M2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1045361 -- 10,581,324(-) CTGTC(A/G)GGAAT reference, synonymous-codon
rs1045467 -- 10,572,705(-) CTCCT(C/T)TGAAT utr-variant-3-prime
rs1560712 -- 10,575,183(-) gtaga(C/G)atggt intron-variant
rs1821279 -- 10,582,332(-) gggca(C/G)cggtg intron-variant
rs1821280 -- 10,582,331(-) ggcac(C/T)ggtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AP1M2 Gene

Variant ID Type Subtype PubMed ID
nsv833744 CNV Loss 17160897
nsv911042 CNV Loss 21882294
dgv3727n71 CNV Loss 21882294
nsv833745 CNV Loss 17160897
nsv911045 CNV Loss 21882294
nsv911046 CNV Loss 21882294
nsv911047 CNV Loss 21882294

Relevant External Links for AP1M2 Gene

HapMap Linkage Disequilibrium report
AP1M2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AP1M2 Gene

Disorders for AP1M2 Gene

(1) University of Copenhagen DISEASES for AP1M2 Gene

Relevant External Links for AP1M2

Human Genome Epidemiology (HuGE) Navigator
AP1M2
genes like me logo Genes that share disorders with AP1M2: view

No data available for UniProtKB/Swiss-Prot for AP1M2 Gene

Publications for AP1M2 Gene

  1. Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells. (PMID: 10338135) Ohno H. … Bonifacino J.S. (FEBS Lett. 1999) 2 3 4
  2. Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2). (PMID: 10640811) Nakatsu F. … Ohno H. (Cytogenet. Cell Genet. 1999) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment. (PMID: 15182197) Park S.Y. … Lee W. (Biochemistry 2004) 3

Products for AP1M2 Gene

Sources for AP1M2 Gene

Back to Top

Content