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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AP1M1 Gene

protein-coding GIFtS: 57
GCID: GC19P016308

adaptor-related protein complex 1, mu 1 subunit

Explore 6 diseases affiliated with
AP1M1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adaptor-Related Protein Complex 1, Mu 1 Subunit¹ ²		AP-Mu Chain Family Member Mu1A² ³
AP47¹ ² ⁵		MU-1A²
CLAPM2¹ ² ⁵		AP-1 Complex Subunit Mu-1²
Adaptor Protein Complex AP-1 Mu-1 Subunit² ³		Clathrin Adaptor Protein AP47²
Adaptor-Related Protein Complex 1 Mu-1 Subunit² ³		Clathrin Assembly Protein Complex 1, Medium Chain²
Clathrin Assembly Protein Complex 1 Medium Chain 1² ³		Clathrin Assembly Protein Complex AP1, Mu Subunit²
Clathrin Coat Assembly Protein AP47² ³		Golgi Adaptor AP-1 47 KDa Protein²
Clathrin Coat-Associated Protein AP47² ³		HA1 47 KDa Subunit²
Golgi Adaptor HA1/AP1 Adaptin Mu-1 Subunit² ³		Mu1A-Adaptin¹
Mu-Adaptin 1² ³		Mu1A-Adaptin¹
CLTNM² ³

External Ids:	HGNC: 13667¹	Entrez Gene: 8907²	Ensembl: ENSG00000072958⁷	OMIM: 603535⁵	UniProtKB: Q9BXS5³

Export aliases for AP1M1 gene to outside databases

Previous GC identifers: GC19M016771 GC19P016702 GC19P016153 GC19P016169 GC19P015879

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AP1M1:

The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex

AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This

complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are

involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein

isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AP1M1_HUMAN, Q9BXS5

Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the

trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the

recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

Gene Wiki entry for AP1M1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AP1M1 gene promoter:
RFX1 p53 AML1a HOXA5 POU3F1 ZIC2/Zic2 LUN-1 POU3F2 Arnt
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AP1M1 promoter sequence

Search SABiosciences Chromatin IP Primers for AP1M1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP1M1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.12

AP1M1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP1M1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P016308: view genomic region (about GC identifiers)

Start:	16,308,389 bp from pter	End:	16,346,160 bp from pter
Size:	37,772 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AP1M1_HUMAN, Q9BXS5 (See protein sequence)

Recommended Name: AP-1 complex subunit mu-1

Size: 423 amino acids; 48587 Da

Subunit: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1

and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type

subunit AP1S1 or AP1S2 or AP1S3). Interacts with MARCH11 (By similarity). Interacts with HIV-1 Nef. Associates with

the AP1(MU)-Nef-MHC-I complex; this complex is required for MHC-I internalization

Subcellular location: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane

protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at

the Golgi complex

Secondary accessions: Q4TTY5

Alternative splicing: 2 isoforms: Q9BXS5-1 Q9BXS5-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AP1M1: NX_Q9BXS5

Post-translational modifications:

Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BXS5

AP1M1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001123996.1 NP_115882.1

ENSEMBL proteins:

ENSP00000291439 ENSP00000466858 ENSP00000465224 ENSP00000411498 ENSP00000388996

ENSP00000468140 ENSP00000467721 ENSP00000467417 ENSP00000468015 ENSP00000445682

Reactome Protein details: Q9BXS5
Human Recombinant Protein Products:

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	Novus Biologicals AP1M1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005765	lysosomal membrane	TAS	--
GO:0005829	cytosol	TAS	--
GO:0030131	clathrin adaptor complex	IEA	--
GO:0030659	cytoplasmic vesicle membrane	TAS	--

AP1M1 for ontologies About GeneDecksing

AP1M1 Antibody Products:

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	GenScript Custom Superior Antibodies Services for AP1M1
	Novus Biologicals AP1M1 Antibodies
	Search for Antibodies for AP1M1 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for AP1M1

Assay Products for AP1M1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for AP1M1
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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AP1M1 for domains About GeneDecksing

5 InterPro domains/families:

IPR018240 Clathrin_mu_CS

IPR001392 Clathrin_mu

IPR008968 Clathrin_mu_C

IPR022775 AP_mu_sigma_su

IPR011012 Longin-like_dom

Graphical View of Domain Structure for InterPro Entry Q9BXS5

ProtoNet protein and cluster: Q9BXS5

1 Blocks protein family: IPB001392 Clathrin adaptor complex

UniProtKB/Swiss-Prot: AP1M1_HUMAN, Q9BXS5

Similarity: Belongs to the adaptor complexes medium subunit family

Similarity: Contains 1 MHD (mu homology) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AP1M1_HUMAN, Q9BXS5

Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the

trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the

recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

miRNA Products:		OriGene 3'-UTR Clone (see all 2): AP1M1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AP1M1
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate AP1M1 (see all 15):
		hsa-miR-520e hsa-miR-302d hsa-miR-4300 hsa-miR-196a* hsa-miR-302a hsa-miR-302e hsa-miR-373 hsa-miR-920

		SwitchGear 3'UTR luciferase reporter plasmid: AP1M1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AP1M1 (see all 7) OriGene shRNA RFP: AP1M1 OriGene siRNA: AP1M1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AP1M1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for AP1M1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP1M1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP1M1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): AP1M1 (NM_032493)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AP1M1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP1M1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for AP1M1
		Search LifeMap BioReagents cell lines for AP1M1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1M1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19060904

AP1M1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for AP1M1:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Ap1m1^tm1Schu for AP1M1
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ap1m1):

cardiovascular system

mortality/aging

AP1M1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Clathrin derived vesicle budding

	Clathrin derived vesicle budding	1.00			Golgi Associated Vesicle Biogenesis	0.89
	trans-Golgi Network Vesicle Budding	1.00			Lysosome Vesicle Biogenesis	0.39

Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	1.00			Nef mediated downregulation of MHC class I complex cell surface expression	0.48
	The role of Nef in HIV-1 replication and disease pathogenesis	0.75			Degradation of MHC I Complex	0.48

Clathrin-dependent protein traffic

Clathrin-dependent protein traffic

1.00

Transport_Clathrin-coated vesicle cycle

0.66

Immune System

Immune System

1.00

Adaptive Immune System

0.59

HIV Infection

HIV Infection

1.00

Host Interactions of HIV factors

0.64

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for AP1M1

Clathrin-dependent protein traffic

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AP1M1

CTLA4 Signaling

1 GeneGo (Thomson Reuters) Pathway for AP1M1

Transport Clathrin-coated vesicle cycle

1 BioSystems Pathway for AP1M1

E-cadherin signaling in the nascent adherens junction

5/15 Reactome Pathways for AP1M1 (see all 15)

	Membrane Trafficking
	Clathrin derived vesicle budding
	trans-Golgi Network Vesicle Budding
	Adaptive Immune System
	Lysosome Vesicle Biogenesis

1 Kegg Pathway (Kegg details for AP1M1):

Lysosome

AP1M1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AP1M1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/159 Interacting proteins for AP1M1 (Q9BXS5^{1, 2, 3} ENSP00000388996⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 159)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	IEA	--
GO:0006892	post-Golgi vesicle-mediated transport	TAS	--
GO:0016032	viral reproduction	TAS	--
GO:0016044	cellular membrane organization	TAS	--
GO:0016192	vesicle-mediated transport	--	--

AP1M1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for AP1M1:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AP1M1
Search CenterWatch for drugs/clinical trials and news about AP1M1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AP1M1 gene (2 alternative transcripts):

NM_001130524.1 NM_032493.3

Unigene Cluster for AP1M1:

Adaptor-related protein complex 1, mu 1 subunit

Hs.71040 [show with all ESTs]

Unigene Representative Sequence: NM_001130524

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000291439(uc002ndu.2 uc010xpd.1) ENST00000590263 ENST00000590756

ENST00000429941 ENST00000589991 ENST00000444449(uc002ndv.2) ENST00000589822

ENST00000590945 ENST00000591775 ENST00000586957 ENST00000589782 ENST00000591966

ENST00000586461 ENST00000586543 ENST00000592703 ENST00000541844

miRNA Products:		OriGene 3'-UTR Clone (see all 2): AP1M1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AP1M1
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate AP1M1 (see all 15):
		hsa-miR-520e hsa-miR-302d hsa-miR-4300 hsa-miR-196a* hsa-miR-302a hsa-miR-302e hsa-miR-373 hsa-miR-920

		SwitchGear 3'UTR luciferase reporter plasmid: AP1M1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AP1M1 (see all 7) OriGene shRNA RFP: AP1M1 OriGene siRNA: AP1M1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AP1M1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP1M1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP1M1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): AP1M1 (NM_032493)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AP1M1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP1M1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP1M1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP1M1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP1M1

Additional cDNA sequence:

AB209808.1 AF290613.1 AK027528.1 AK293188.1 AK297824.1 BC017469.2 DQ059565.1

19 DOTS entries:

DT.448197 DT.100811948 DT.95267177 DT.100811941 DT.100680978 DT.100811949 DT.97855601 DT.97855597

DT.100657724 DT.100701761 DT.100717931 DT.100840990 DT.101976155 DT.121498201 DT.121498205 DT.121498236

DT.91693054 DT.92442991 DT.427126

24/462 AceView cDNA sequences (see all 462):

M85399 BM927338 BF739970 AI015767 BE407731 CR619890 BQ057254 BM695039

BQ683971 BQ940276 BI767077 BX341227 BQ060961 BE207211 BQ644564 NM_032493

BE796246 BX107167 BQ063575 BQ024469 BQ917882 BQ055771 AL548364 BM743603

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AP1M1 (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15a	·	15b	·	15c
SP1:											-						-		-		-								-														-
SP2:											-						-		-		-				-				-														-
SP3:			-		-				-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-				-
SP4:																									-				-
SP5:

ECgene alternative splicing isoforms for AP1M1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AP1M1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCCACCCAC

About this image
See AP1M1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AP1M1

SOURCE GeneReport for Unigene cluster: Hs.71040

SABiosciences Custom PCR Arrays for AP1M1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP1M1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP1M1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP1M1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1M1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for AP1M1 gene from 10/35 species (see all 35) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ap1m1^{1 , 5}	adaptor-related protein complex AP-1, mu subunit 1^{1, 5}	89.2(n)¹ 99.29(a)¹		8 (34.92 cM)⁵ 11767¹ NM_007456.4¹ NP_031482.1¹ 72240018⁵
chicken (Gallus gallus)	Aves	AP1M1¹	adaptor-related protein complex 1, mu 1 subunit	79.2(n) 99.76(a)		420149 NM_001007886.1 NP_001007887.1
lizard (Anolis carolinensis)	Reptilia	AP1M1⁶	--	94(a)	1 ↔ 1	AAWZ02038146(1067-12380)
African clawed frog (Xenopus laevis)	Amphibia	Xl.7449²	Xenopus laevis transcribed sequence with strong similarity more	77.06(n)		CD300993.1
zebrafish (Danio rerio)	Actinopterygii	ap1m3¹	adaptor-related protein complex 1, mu 3 subunit	72.51(n) 79.15(a)		445244 NM_001114441.1 NP_001107913.1
fruit fly (Drosophila melanogaster)	Insecta	AP-47^{1 , 3}	non-selective vesicle coating³ AP-47¹	82(a)³ 75.93(n)¹ 83.85(a)¹		85D24³ 41150¹ NM_141649.1¹ NP_649906.1¹
worm (Caenorhabditis elegans)	Secernentea	unc-101^{1 , 3}	clathrin coat assembly protein³ Protein UNC-101¹	75(a) (best of 2)³ 65.79(n)¹ 75.48(a)¹		I(12516608-12520954)³ 173121¹ NM_001047210.1¹ NP_001040675.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	APM1(YPL259C)⁴ APM1¹	Mu1-like medium subunit of the clathrin-associated more⁴ Apm1p¹	53.91(n)¹ 58.13(a)¹		16(52671-51244)⁴ 855869^{1, 4} NP_015064.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	HAP13¹	AP-1 complex subunit mu	59.03(n) 61.81(a)		842372 NM_104761.3 NP_176277.1
rice (Oryza sativa)	Liliopsida	Os01g0703600¹	hypothetical protein	60.38(n) 62.29(a)		4324247 NM_001050536.1 NP_001044001.1

ENSEMBL Gene Tree for AP1M1 (if available)
TreeFam Gene Tree for AP1M1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AP1M1 gene

AP3M1² AP4M1² AP1M2² AP3M2² AP2M1²

7 SIMAP similar genes for AP1M1 using alignment to 9 protein entries: AP1M1_HUMAN (see all proteins):

AP1M2 AP2M1 AP3M2 DKFZp686E11263 AP3M1 DKFZp586G1518

AP4M1

AP1M1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs55906166^1,2		--	16306684(+)	`TGAGCC/TGAGAT`	2	--	us2k¹		0	--	--	--	--
rs138830371^1,2		--	16306729(+)	`GACTCC/TGTCTC`	2	--	us2k¹		0	--	--	--	--
rs58371582^1,2	C,	--	16306747(+)	`AAATTT/AAAAAA`	2	--	us2k¹		1		WA	2
rs59084131^1,2	C,	--	16306810(+)	`CTATAC/TATGGC`	2	--	us2k¹		2		WA	120
rs58361923^1,2	C,	--	16306811(+)	`TATACA/GTGGCT`	2	--	us2k¹		2		WA	120
rs67505843^1,2	C,F,	--	16306846(+)	`TGTGTG/ATTGTA`	2	--	us2k¹		5		WA NA EA	362
rs143695943^1,2		--	16306928(+)	`CACAGC/TCCAAT`	2	--	us2k¹		0	--	--	--	--
rs187138439^1,2		--	16307201(+)	`TCCAGA/GTGCTG`	2	--	us2k¹		0	--	--	--	--
rs67482419^1,2	C,F,	--	16307243(+)	`ATCATG/AGAGGT`	2	--	us2k¹		5		WA NA EA	362
rs115627627^1,2	F,	--	16307417(+)	`GTGGGC/TTTTTG`	2	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for AP1M1 (16308389 - 16346160 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AP1M1: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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AP1M1 for disorders           About GeneDecksing

OMIM gene information: 603535    OMIM disorders: --

6 diseases for AP1M1:    About MalaCards

renal tubular acidosis kaposi's sarcoma sarcoma immunodeficiency

malaria neuronitis

1 disease from the University of Copenhagen DISEASES database for AP1M1:

Renal tubular acidosis

Export disorders for AP1M1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for AP1M1 gene, integrated from 9 sources (see all 79):
(articles sorted by number of sources associating them with AP1M1)

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AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin. (PubMed id 17988225)^{1, 3} Medigeshi G.R....Schu P. (2008)
The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail. (PubMed id 18073204)^{1, 2} Wonderlich E.R....Collins K.L. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG). (PubMed id 9653655)^{1, 3} Peyrard M.... Dumanski J.P. (1998)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Global landscape of HIV-human protein complexes. (PubMed id 22190034)¹ Jager S....Krogan N.J. (2012)
Nef-arious goings-on at the Golgi. (PubMed id 22767237)¹ Hurley J.H. and Bonifacino J.S. (2012)
Structural basis of evasion of cellular adaptive immun ity by HIV-1 Nef. (PubMed id 22705789)¹ Jia X....Xiong Y. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8907	HGNC: 13667	AceView: AP1M1	Ensembl:ENSG00000072958	euGenes: HUgn8907
ECgene: AP1M1	Kegg: 8907	H-InvDB: AP1M1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for AP1M1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AP1M1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for AP1M1 gene:
Search GeneIP for patents involving AP1M1

GeneCards and IP:
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AP1M1 Gene

adaptor-related protein complex 1, mu 1 subunit

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AP1M1 (Gene Symbol)
Adaptor-Related Protein Complex 1, Mu 1 Subunit
AP47
CLAPM2
Adaptor Protein Complex AP-1 Mu-1 Subunit
Adaptor-Related Protein Complex 1 Mu-1 Subunit
Clathrin Assembly Protein Complex 1 Medium Chain 1
Clathrin Coat Assembly Protein AP47
Clathrin Coat-Associated Protein AP47
Golgi Adaptor HA1/AP1 Adaptin Mu-1 Subunit
Mu-Adaptin 1
CLTNM
AP-Mu Chain Family Member Mu1A
MU-1A
AP-1 Complex Subunit Mu-1
Clathrin Adaptor Protein AP47
Clathrin Assembly Protein Complex 1, Medium Chain
Clathrin Assembly Protein Complex AP1, Mu Subunit
Golgi Adaptor AP-1 47 KDa Protein
HA1 47 KDa Subunit
Mu1A-Adaptin
Mu1A-Adaptin

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AP1M1 Gene

adaptor-related protein complex 1, mu 1 subunit

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