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AP1M1 Gene

protein-coding   GIFtS: 62
GCID: GC19P016308

Adaptor-Related Protein Complex 1, Mu 1 Subunit

  Search for AP1M1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adaptor-Related Protein Complex 1, Mu 1 Subunit1 2     MU-1A2
Adapter-Related Protein Complex 1 Subunit Mu-12 3     Adaptor Protein Complex AP-1 Mu-1 Subunit2
Adaptor Protein Complex AP-1 Subunit Mu-12 3     Adaptor-Related Protein Complex 1 Mu-1 Subunit2
Clathrin Assembly Protein Complex 1 Mu-1 Medium Chain 12 3     AP-1 Complex Subunit Mu-12
Clathrin Coat Assembly Protein AP472 3     Clathrin Adaptor Protein AP472
Clathrin Coat-Associated Protein AP472 3     Clathrin Assembly Protein Complex 1 Medium Chain 12
Golgi Adaptor HA1/AP1 Adaptin Mu-1 Subunit2 3     Clathrin Assembly Protein Complex 1, Medium Chain2
Mu-Adaptin 12 3     Clathrin Assembly Protein Complex AP1, Mu Subunit2
CLTNM2 3     Golgi Adaptor AP-1 47 KDa Protein2
AP-Mu Chain Family Member Mu1A2 3     HA1 47 KDa Subunit2
AP472 5     mu1A-adaptin2
CLAPM22 5     Mu1A-adaptin3

External Ids:    HGNC: 136671   Entrez Gene: 89072   Ensembl: ENSG000000729587   OMIM: 6035355   UniProtKB: Q9BXS53   

Export aliases for AP1M1 gene to outside databases

Previous GC identifers: GC19M016771 GC19P016702 GC19P016153 GC19P016169 GC19P015879


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AP1M1 Gene:
The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein
complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain
AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These
vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding
distinct protein isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for AP1M1 Gene:
AP1M1 (adaptor-related protein complex 1, mu 1 subunit) is a protein-coding gene. An important paralog of this gene is AP3M1.

UniProtKB/Swiss-Prot: AP1M1_HUMAN, Q9BXS5
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the
trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and
the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

Gene Wiki entry for AP1M1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the AP1M1 gene promoter:
         RFX1   p53   AML1a   HOXA5   POU3F1   ZIC2/Zic2   LUN-1   POU3F2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAP1M1 promoter sequence
   Search Chromatin IP Primers for AP1M1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AP1M1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.12

AP1M1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP1M1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P016308:  view genomic region     (about GC identifiers)

Start:
16,308,389 bp from pter      End:
16,346,160 bp from pter
Size:
37,772 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AP1M1_HUMAN, Q9BXS5 (See protein sequence)
Recommended Name: AP-1 complex subunit mu-1  
Size: 423 amino acids; 48587 Da
Subunit: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit
AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin
(sigma-type subunit AP1S1 or AP1S2 or AP1S3). Interacts with MARCH11 (By similarity). Interacts with HIV-1 Nef.
Associates with the AP1(MU)-Nef-MHC-I complex; this complex is required for MHC-I internalization
Secondary accessions: Q4TTY5
Alternative splicing: 2 isoforms:  Q9BXS5-1   Q9BXS5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AP1M1: NX_Q9BXS5

Explore proteomics data for AP1M1 at MOPED

Post-translational modifications: 

  • Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals (By similarity)1
  • Ubiquitination2 at Lys217, Lys229, Lys237, Lys333, Lys346, Lys400
  • Modification sites at PhosphoSitePlus

  • See AP1M1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123996.1  NP_115882.1  

    ENSEMBL proteins: 
     ENSP00000291439   ENSP00000466858   ENSP00000465224   ENSP00000411498   ENSP00000388996  
     ENSP00000468140   ENSP00000467721   ENSP00000467417   ENSP00000468015   ENSP00000445682  
    Reactome Protein details: Q9BXS5

    AP1M1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for AP1M1 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR018240 Clathrin_mu_CS
     IPR008968 Clathrin_mu_C
     IPR022775 AP_mu_sigma_su
     IPR011012 Longin-like_dom
     IPR028565 MHD

    Graphical View of Domain Structure for InterPro Entry Q9BXS5

    ProtoNet protein and cluster: Q9BXS5

    1 Blocks protein domain: IPB001392 Clathrin adaptor complex

    UniProtKB/Swiss-Prot: AP1M1_HUMAN, Q9BXS5
    Similarity: Belongs to the adaptor complexes medium subunit family
    Similarity: Contains 1 MHD (mu homology) domain


    Find genes that share domains with AP1M1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP1M1_HUMAN, Q9BXS5
    Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the
    trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and
    the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14691137
         
    Find genes that share ontologies with AP1M1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AP1M1:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ap1m1):
     cardiovascular system  mortality/aging 

    Find genes that share phenotypes with AP1M1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ap1m1tm1Schu for AP1M1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AP1M1
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    miRTarBase miRNAs that target AP1M1:
    hsa-mir-7-5p (MIRT025884), hsa-mir-181a-5p (MIRT047323), hsa-mir-877-3p (MIRT036991), hsa-mir-1 (MIRT023891)

    Block miRNA regulation of human, mouse, rat AP1M1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AP1M1 (see all 15):
    hsa-miR-520e hsa-miR-302d hsa-miR-4300 hsa-miR-196a* hsa-miR-302a hsa-miR-302e hsa-miR-373 hsa-miR-920
    SwitchGear 3'UTR luciferase reporter plasmidAP1M1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1M1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AP1M1_HUMAN, Q9BXS5: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane
    protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located
    at the Golgi complex
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol4
    lysosome4
    vacuole4
    endoplasmic reticulum2
    mitochondrion2
    endosome1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005765lysosomal membrane TAS--
    GO:0005829cytosol TAS--
    GO:0016020membrane ----
    GO:0030131clathrin adaptor complex IEA--

    Find genes that share ontologies with AP1M1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AP1M1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    Transport Clathrin coated vesicle cycle0.66
    2Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    Lysosome Vesicle Biogenesis0.41
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32
    trans-Golgi Network Vesicle Budding0.89
    3Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
    Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters0.76
    Nef mediated downregulation of MHC class I complex cell surface expression0.00
    The role of Nef in HIV-1 replication and disease pathogenesis0.76
    4HIV Life Cycle
    HIV Infection0.62
    Host Interactions of HIV factors0.60
    5Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41


    Find genes that share SuperPaths with AP1M1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AP1M1
        CTLA4 Signaling

    1 GeneGo (Thomson Reuters) Pathway for AP1M1
        Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for AP1M1
        E-cadherin signaling in the nascent adherens junction

    4 Reactome Pathways for AP1M1
        Golgi Associated Vesicle Biogenesis
    Lysosome Vesicle Biogenesis
    Nef mediated downregulation of MHC class I complex cell surface expression
    MHC class II antigen presentation


    1 Kegg Pathway  (Kegg details for AP1M1):
        Lysosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AP1M1
    Interactions:

        Search GeneGlobe Interaction Network for AP1M1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AP1M1 (Q9BXS51, 2, 3 ENSP000003889964) via UniProtKB, MINT, STRING, and/or I2D (see all 177)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006886intracellular protein transport IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0015031protein transport ----
    GO:0016032viral process TAS--

    Find genes that share ontologies with AP1M1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AP1M1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AP1M1 gene (2 alternative transcripts): 
    NM_001130524.1  NM_032493.3  

    Unigene Cluster for AP1M1:

    Adaptor-related protein complex 1, mu 1 subunit
    Hs.71040  [show with all ESTs]
    Unigene Representative Sequence: NM_001130524
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291439(uc002ndu.2 uc010xpd.1) ENST00000590263 ENST00000590756
    ENST00000429941 ENST00000589991 ENST00000444449(uc002ndv.2) ENST00000589822
    ENST00000590945 ENST00000591775 ENST00000586957 ENST00000589782 ENST00000591966
    ENST00000586461 ENST00000586543 ENST00000592703 ENST00000541844
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    Selected qRT-PCR Assays for microRNAs that regulate AP1M1 (see all 15):
    hsa-miR-520e hsa-miR-302d hsa-miR-4300 hsa-miR-196a* hsa-miR-302a hsa-miR-302e hsa-miR-373 hsa-miR-920
    SwitchGear 3'UTR luciferase reporter plasmidAP1M1 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat AP1M1
      QuantiFast Probe-based Assays in human, mouse, rat AP1M1

    Additional mRNA sequence: 

    AB209808.1 AF290613.1 AK027528.1 AK293188.1 AK297824.1 BC017469.2 DQ059565.1 

    19 DOTS entries:

    DT.448197  DT.100811948  DT.95267177  DT.100811941  DT.100680978  DT.100811949  DT.97855601  DT.97855597 
    DT.100657724  DT.100701761  DT.100717931  DT.100840990  DT.101976155  DT.121498201  DT.121498205  DT.121498236 
    DT.91693054  DT.92442991  DT.427126 

    Selected AceView cDNA sequences (see all 462):

    BQ056872 AA226922 BI261804 BQ953425 BQ652769 BM552924 AI570705 AK027528 
    AA305197 AA847774 BQ213569 BQ064990 BU857681 BQ065572 BM759632 AW090711 
    BM927338 BQ059327 BQ940276 BF739970 AA995577 BE796246 BQ063575 BQ643483 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AP1M1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
    SP1:                                -                 -     -     -                       -                                         -                           
    SP2:                                -                 -     -     -           -           -                                         -                           
    SP3:        -     -           -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -           -                           
    SP4:                                                                          -           -                                                                     
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for AP1M1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AP1M1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCACCCAC
    AP1M1 Expression
    About this image

    AP1M1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AP1M1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.71040
        Custom PCR Arrays for AP1M1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1M1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AP1M1 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ap1m11 , 5 adaptor-related protein complex AP-1, mu subunit 11, 5 89.2(n)1
    99.29(a)1
      8 (34.92 cM)5
    117671  NM_007456.41  NP_031482.11 
     722400185 
    chicken
    (Gallus gallus)
    Aves AP1M11 adaptor-related protein complex 1, mu 1 subunit 79.2(n)
    99.76(a)
      420149  NM_001007886.1  NP_001007887.1 
    lizard
    (Anolis carolinensis)
    Reptilia AP1M16
    adaptor-related protein complex 1, mu 1 subunit
    95(a)
    1 ↔ 1
    AAWZ02038146(789-12830)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.74492 Xenopus laevis transcribed sequence with strong similarity more 77.06(n)    CD300993.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ap1m31 adaptor-related protein complex 1, mu 3 subunit 72.42(n)
    78.96(a)
      445244  NM_001114441.1  NP_001107913.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AP-471 , 3 non-selective vesicle coating3
    AP-471
    82(a)3
    75.93(n)1
    83.85(a)1
      85D243
    411501  NM_141649.21  NP_649906.11 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1011 , 3 clathrin coat assembly protein3
    unc-1011
    75(a)
    (best of 2)3
    65.64(n)1
    75.12(a)1
      I(12516608-12520954)3
    1731211  NM_001047210.21  NP_001040675.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APM1(YPL259C)4
    APM11
    Mu1-like medium subunit of the clathrin-associated more4
    APM11
    54.04(n)1
    58.51(a)1
      16(52671-51244)4
    8558691, 4  NP_015064.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HAP131 HAP13 59.03(n)
    61.81(a)
      842372  NM_104761.3  NP_176277.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07036001 Os01g0703600 60.38(n)
    62.29(a)
      4324247  NM_001050536.1  NP_001044001.1 


    ENSEMBL Gene Tree for AP1M1 (if available)
    TreeFam Gene Tree for AP1M1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AP1M1 gene
    AP3M12  AP4M12  AP1M22  AP3M22  AP2M12  
    7 SIMAP similar genes for AP1M1 using alignment to 9 protein entries:     AP1M1_HUMAN (see all proteins):
    AP1M2    AP2M1    AP3M2    DKFZp686E11263    AP3M1    DKFZp586G1518
    AP4M1

    Find genes that share paralogs with AP1M1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for AP1M1 (see all 909)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365364
    A breast cancer sample4--see VAR_0365362 R Q mis40--------
    rs559061661,2
    C--16306684(+) TGAGCC/TGAGAT 2 -- us2k10--------
    rs1388303711,2
    --16306729(+) GACTCC/TGTCTC 2 -- us2k10--------
    rs583715821,2
    C,F--16306747(+) AAATTT/AAAAAA 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs3715182301,2
    C--16306747(+) AAAAT-/AAAAA 
            
    AAAAA
    2 -- us2k10--------
    rs590841311,2
    C,F--16306810(+) CTATAC/TATGGC 2 -- us2k12Minor allele frequency- T:0.04WA 120
    rs583619231,2
    C,F--16306811(+) TATACA/GTGGCT 2 -- us2k12Minor allele frequency- G:0.04WA 120
    rs675058431,2
    C,F--16306846(+) TGTGTG/ATTGTA 2 -- us2k15Minor allele frequency- A:0.19WA NA EA 362
    rs1436959431,2
    --16306928(+) CACAGC/TCCAAT 2 -- us2k10--------
    rs1871384391,2
    --16307201(+) TCCAGA/GTGCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for AP1M1 (16308389 - 16346160 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for AP1M1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833767CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AP1M1
    DNA2.0 Custom Variant and Variant Library Synthesis for AP1M1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603535    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for AP1M1:
    Renal tubular acidosis

    Find genes that share disorders with AP1M1           About GenesLikeMe

    Genetic Association Database (GAD): AP1M1

    Export disorders for AP1M1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AP1M1 gene, integrated from 10 sources (see all 89):
    (articles sorted by number of sources associating them with AP1M1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin. (PubMed id 17988225)1, 3 Medigeshi G.R....Schu P. (Traffic 2008)
    2. The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail. (PubMed id 18073204)1, 2 Wonderlich E.R.... Collins K.L. (J. Biol. Chem. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG). (PubMed id 9653655)1, 3 Peyrard M.... Dumanski J.P. (Genomics 1998)
    5. Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1. (PubMed id 23678182)1 Kulpa D.A....Collins K.L. (J. Virol. 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    8. The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation. (PubMed id 23478262)1 Yoneyama Y....Takahashi S. (Mol. Cell. Biol. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8907 HGNC: 13667 AceView: AP1M1 Ensembl:ENSG00000072958 euGenes: HUgn8907
    ECgene: AP1M1 Kegg: 8907 H-InvDB: AP1M1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AP1M1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AP1M1 gene:
    Search GeneIP for patents involving AP1M1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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