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AP1G2 Gene

protein-coding   GIFtS: 56
GCID: GC14M024028

Adaptor-Related Protein Complex 1, Gamma 2 Subunit

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Adaptor-Related Protein Complex 1, Gamma 2 Subunit1 2     gamma2-adaptin2
G2AD2     G2ad3
AP-1 Complex Subunit Gamma-Like 22     Gamma2-adaptin3
Clathrin-Associated/Assembly/Adaptor Protein, Large, Gamma-22     

External Ids:    HGNC: 5561   Entrez Gene: 89062   Ensembl: ENSG000002139837   OMIM: 6035345   UniProtKB: O758433   
ORGUL members:         

Export aliases for AP1G2 gene to outside databases

Previous GC identifers: GC14M021401 GC14M017817 GC14M022018 GC14M023098 GC14M004145


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AP1G2 Gene:
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the
plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is compsed of four
classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and
small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of
clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to
the adaptor complexes large subunits family. This protein along with the complex is thought to function at some
trafficking step in the complex pathways between the trans-Golgi network and the cell surface. Several
alternatively spliced transcript variants of this gene exist, but their full-length nature is not known.
(provided by RefSeq, Aug 2013)

GeneCards Summary for AP1G2 Gene:
AP1G2 (adaptor-related protein complex 1, gamma 2 subunit) is a protein-coding gene. Diseases associated with AP1G2 include kaposi's sarcoma, and hiv-1. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is AP1G1.

UniProtKB/Swiss-Prot: AP1G2_HUMAN, O75843
Function: May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in
MVB-assisted maturation of hepatitis B virus (HBV)

Gene Wiki entry for AP1G2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AP1G2 gene promoter:
         Sp1   Pax-5   AP-2gamma   Tal-1beta   GATA-1   E47   COMP1   AP-2beta   RSRFC4   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AP1G2 promoter sequence
   Search Chromatin IP Primers for AP1G2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AP1G2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

AP1G2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP1G2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M024028:  view genomic region     (about GC identifiers)

Start:
24,028,774 bp from pter      End:
24,037,279 bp from pter
Size:
8,506 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AP1G2_HUMAN, O75843 (See protein sequence)
Recommended Name: AP-1 complex subunit gamma-like 2  
Size: 785 amino acids; 87117 Da
Subunit: Probably interacts with AP1S1/Sigma1A-adaptin AP1S2/Sigma1B-adaptin. Probably does not interact with
APB1. Interacts with HBV major surface antigen L. Interacts with HBV core protein C in a ubiquitin-dependent
manner. Binds ubiquitin
Caution: Does not appear to be a subunit of the clathrin-associated adaptor protein complex 1 (AP-1)
Sequence caution: Sequence=AAC67390.1; Type=Frameshift; Positions=713;
4 PDB 3D structures from and Proteopedia for AP1G2:
2E9G (3D)        2YMT (3D)        3ZHF (3D)        4BCX (3D)    
Secondary accessions: D3DS51 O75504

Explore the universe of human proteins at neXtProt for AP1G2: NX_O75843

Explore proteomics data for AP1G2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys7, Lys145, Lys584
  • Modification sites at PhosphoSitePlus

  • See AP1G2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269403.1  NP_001269404.1  NP_003908.1  

    ENSEMBL proteins: 
     ENSP00000312442   ENSP00000380309   ENSP00000450805   ENSP00000450588   ENSP00000450888  
     ENSP00000452153   ENSP00000451343   ENSP00000451504  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR017107 AP1_complex_gsu
     IPR011989 ARM-like
     IPR002553 Clathrin/coatomer_adapt-like_N
     IPR013041 Coatomer/clathrin_app_Ig-like
     IPR008152 Clathrin_a/b/g-adaptin_app_Ig

    Graphical View of Domain Structure for InterPro Entry O75843

    ProtoNet protein and cluster: O75843

    3 Blocks protein domains:
    IPB002553 Adaptin
    IPB008152 Alpha/gamma adaptin
    IPB008153 Gamma-adaptin


    UniProtKB/Swiss-Prot: AP1G2_HUMAN, O75843
    Similarity: Belongs to the adaptor complexes large subunit family
    Similarity: Contains 1 GAE domain


    AP1G2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP1G2_HUMAN, O75843
    Function: May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in
    MVB-assisted maturation of hepatitis B virus (HBV)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI12505986
    GO:0008565protein transporter activity IEA--
         
    AP1G2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AP1G2
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    hsa-miR-370 hsa-miR-138
    SwitchGear 3'UTR luciferase reporter plasmidAP1G2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AP1G2_HUMAN, O75843: Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane;
    Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Mainly localized to perinuclear
    vesicular structures. Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing
    compartments. Colocalizes with HBV major surface antigen L to cis-Golgi-like structures
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    golgi apparatus5
    cytosol3
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus TAS9762922
    GO:0005798Golgi-associated vesicle IDA9762922
    GO:0010008endosome membrane IEA--
    GO:0016020membrane IDA9733768
    GO:0030117membrane coat ----

    AP1G2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AP1G2 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    Transport Clathrin coated vesicle cycle0.66
    2CD28 co-stimulation
    CTLA4 Signaling0.30
    3Lysosome
    Lysosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AP1G2
        CTLA4 Signaling

    1 GeneGo (Thomson Reuters) Pathway for AP1G2
        Transport Clathrin-coated vesicle cycle


    1 Kegg Pathway  (Kegg details for AP1G2):
        Lysosome


    AP1G2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AP1G2
    Interactions:

        GeneGlobe Interaction Network for AP1G2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AP1G2 (O758431, 2, 3 ENSP000003124424) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RABEP1Q152761, 3, ENSP000002624774EBI-373637,EBI-447043 I2D: score=2 STRING: ENSP00000262477
    XRN1Q8IZH23, ENSP000002649514I2D: score=3 STRING: ENSP00000264951
    AP1S1P619663, ENSP000003366664I2D: score=1 STRING: ENSP00000336666
    SYNRGQ9UMZ23, ENSP000000052794I2D: score=1 STRING: ENSP00000005279
    NEDD4P469343, ENSP000003455304I2D: score=1 STRING: ENSP00000345530
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0015031protein transport ----
    GO:0016032viral process IEA--
    GO:0016192vesicle-mediated transport NAS9733768
    GO:0019048modulation by virus of host morphology or physiology ----

    AP1G2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AP1G2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AP1G2 gene (4 alternative transcripts): 
    NM_001282474.1  NM_001282475.1  NM_003917.4  NM_080545.1  

    Unigene Cluster for AP1G2:

    Adaptor-related protein complex 1, gamma 2 subunit
    Hs.343244  [show with all ESTs]
    Unigene Representative Sequence: AF068706
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):
    ENST00000308724(uc010tnq.1 uc010tnp.1 uc001wkl.2 uc001wkn.2)
    ENST00000554892 ENST00000554554(uc001wkp.1) ENST00000397120 ENST00000535852(uc001wkk.3)
    ENST00000460049 ENST00000465445 ENST00000557391 ENST00000554477 ENST00000555510
    ENST00000556966 ENST00000554982 ENST00000555118 ENST00000557132 ENST00000557162
    ENST00000555789 ENST00000555974 ENST00000556741
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    2 qRT-PCR Assays for microRNAs that regulate AP1G2:
    hsa-miR-370 hsa-miR-138
    SwitchGear 3'UTR luciferase reporter plasmidAP1G2 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat AP1G2

    Additional mRNA sequence: 

    AB015318.1 AF068706.1 AK096034.1 AK123354.1 AK226158.1 AK304682.1 AK307696.1 AK309103.1 
    AK310451.1 BC051833.1 BX161425.1 BX247963.1 

    Selected DOTS entries (see all 29):

    DT.95225309  DT.456303  DT.95141898  DT.92049578  DT.95318534  DT.97763153  DT.411162  DT.97848227 
    DT.100882759  DT.91890991  DT.100882744  DT.95225251  DT.120750746  DT.120750789  DT.451129  DT.91702166 
    DT.95161805  DT.100841881  DT.100882738  DT.100882741  DT.100882765  DT.100882770  DT.95225297  DT.100882750 

    Selected AceView cDNA sequences (see all 328):

    CR611477 BQ709146 BQ054727 AI288799 AI348608 BI334956 AW131744 BX384652 
    BM675924 AI423336 BF195169 CB130470 AK091572 BQ937186 BQ049029 BG911312 
    BI524171 BU633321 BM980959 AK055345 BQ185991 BG413503 NM_003917 AI827402 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AP1G2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGCTGCCA
    AP1G2 Expression
    About this image

    AP1G2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AP1G2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.343244

    UniProtKB/Swiss-Prot: AP1G2_HUMAN, O75843
    Tissue specificity: Expressed in all but one (skeletal muscle) tissues examined

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AP1G2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ap1g21 , 5 adaptor protein complex AP-1, gamma 2 subunit1, 5 86.45(n)1
    87.39(a)1
      14 (28.07 cM)5
    117661  NM_007455.41  NP_031481.21 
     550985785 
    zebrafish
    (Danio rerio)
    Actinopterygii ap1g26
    adaptor-related protein complex 1, gamma 2 subunit...
    55(a)
    many ↔ many
    2(37992902-38014304) ENSDARG00000054337
    fruit fly
    (Drosophila melanogaster)
    Insecta AP-1gamma3 non-selective vesicle coating 57(a)   8C9   --
    worm
    (Caenorhabditis elegans)
    Secernentea apg-16
    Protein APG-1 (apg-1) mRNA, complete cds
    41(a)
    1 → many
    I(14406028-14417928) WBGene00000158
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APL41 APL4 43.51(n)
    35.08(a)
      856141   NP_015354.1 


    ENSEMBL Gene Tree for AP1G2 (if available)
    TreeFam Gene Tree for AP1G2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AP1G2 gene
    AP1G12  AP4E12  
    2 SIMAP similar genes for AP1G2 using alignment to 7 protein entries:     AP1G2_HUMAN (see all proteins):
    AP1G1    AP2A2

    AP1G2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AP1G2 (see all 343)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs569088311,2
    --4148475(+) ATTTTA/TAAAAA 1 -- int10--------
    rs111582471,2
    C--4148488(+) aaagaA/GaGAGA 1 -- int10--------
    rs1451320661,2
    C--5025673(+) GCTGAG/TTTAGA 1 -- ds50010--------
    rs1439335301,2
    --5025713(+) GCCTTA/GGGATG 1 -- ds50010--------
    rs1485637341,2
    C--5025849(+) AGGGGC/TAAATT 1 -- ds50010--------
    rs126511,2
    C,F,H--5025925(+) ACAGGT/GTCTCA 1 -- ds500114Minor allele frequency- G:0.16MN NS EA NA WA CSA 1497
    rs796384701,2
    C,F--5025953(+) CATACC/TTCCTA 1 -- ds50011Minor allele frequency- T:0.13WA 118
    rs1903583141,2
    C--5026166(+) GGGTTG/TGGGAC 1 -- ut310--------
    rs1999592651,2
    --5026175(+) ACACAC/GGAGAA 1 -- ut310--------
    rs1414003501,2
    F--5026219(+) GATTCC/TACAGG 2 V syn11Minor allele frequency- T:0.00NA 4546

    HapMap Linkage Disequilibrium report for AP1G2 (24028774 - 24037279 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AP1G2: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing AP1G2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603534    OMIM disorders: --

    7 diseases for AP1G2:    
    About MalaCards
    kaposi's sarcoma    hiv-1    hepatitis b    coronary artery disease
    sarcoma    ataxia    hepatitis


    AP1G2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AP1G2

    Export disorders for AP1G2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AP1G2 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with AP1G2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and localization of a novel gamma-adaptin-like molecule. (PubMed id 9762922)1, 2, 3, 9 Lewin D.A.... Mellman I. (FEBS Lett. 1998)
    2. Identification and characterization of novel clathrin adaptor-related proteins. (PubMed id 9733768)1, 2, 3, 9 Takatsu H.... Nakayama K. (J. Biol. Chem. 1998)
    3. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (BMC Cardiovasc Disord 2011)
    4. Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin. (PubMed id 17553870)1, 2 Lambert C.... Prange R. (J. Virol. 2007)
    5. Hepatitis B virus large envelope protein interacts with gamma2- adaptin, a clathrin adaptor-related protein. (PubMed id 11333915)1, 2 Hartmann-Stuehler C. and Prange R. (J. Virol. 2001)
    6. gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway. (PubMed id 18772139)1, 9 Rost M....Prange R. (J. Biol. Chem. 2008)
    7. Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. (PubMed id 12505986)1, 9 Mattera R.... Bonifacino J.S. (EMBO J. 2003)
    8. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8906 HGNC: 556 AceView: AP1G2 Ensembl:ENSG00000213983 euGenes: HUgn8906
    ECgene: AP1G2 Kegg: 8906 H-InvDB: AP1G2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AP1G2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AP1G2 gene:
    Search GeneIP for patents involving AP1G2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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