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Aliases for AP1G2 Gene

Aliases for AP1G2 Gene

  • Adaptor Related Protein Complex 1 Gamma 2 Subunit 2 3 5
  • Adaptor-Related Protein Complex 1, Gamma 2 Subunit 2 3
  • Adaptor-Related Protein Complex 1 Gamma 2 Subunit 2 3
  • Gamma2-Adaptin 3 4
  • G2AD 3 4
  • Clathrin-Associated/Assembly/Adaptor Protein, Large, Gamma-2 3

External Ids for AP1G2 Gene

Previous GeneCards Identifiers for AP1G2 Gene

  • GC14M021401
  • GC14M017817
  • GC14M022018
  • GC14M023098
  • GC14M024028
  • GC14M004145

Summaries for AP1G2 Gene

Entrez Gene Summary for AP1G2 Gene

  • Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is compsed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. Several alternatively spliced transcript variants of this gene exist, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

GeneCards Summary for AP1G2 Gene

AP1G2 (Adaptor Related Protein Complex 1 Gamma 2 Subunit) is a Protein Coding gene. Among its related pathways are CTLA4 Signaling and Clathrin derived vesicle budding. GO annotations related to this gene include binding and protein transporter activity. An important paralog of this gene is AP4E1.

UniProtKB/Swiss-Prot for AP1G2 Gene

  • May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).

Gene Wiki entry for AP1G2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP1G2 Gene

Genomics for AP1G2 Gene

Regulatory Elements for AP1G2 Gene

Enhancers for AP1G2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AP1G2 on UCSC Golden Path with GeneCards custom track

Promoters for AP1G2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AP1G2 on UCSC Golden Path with GeneCards custom track

Genomic Location for AP1G2 Gene

Chromosome:
14
Start:
23,559,563 bp from pter
End:
23,569,545 bp from pter
Size:
9,983 bases
Orientation:
Minus strand

Genomic View for AP1G2 Gene

Genes around AP1G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP1G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP1G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP1G2 Gene

Proteins for AP1G2 Gene

  • Protein details for AP1G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75843-AP1G2_HUMAN
    Recommended name:
    AP-1 complex subunit gamma-like 2
    Protein Accession:
    O75843
    Secondary Accessions:
    • D3DS51
    • O75504

    Protein attributes for AP1G2 Gene

    Size:
    785 amino acids
    Molecular mass:
    87117 Da
    Quaternary structure:
    • Probably interacts with AP1S1/Sigma1A-adaptin AP1S2/Sigma1B-adaptin. Probably does not interact with APB1. Interacts with HBV major surface antigen L. Interacts with HBV core protein C in a ubiquitin-dependent manner. Binds ubiquitin.
    SequenceCaution:
    • Sequence=AAC67390.1; Type=Frameshift; Positions=713; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AP1G2 Gene

neXtProt entry for AP1G2 Gene

Proteomics data for AP1G2 Gene at MOPED

Post-translational modifications for AP1G2 Gene

  • Ubiquitination at Lys 7, Lys 145, and Lys 584
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for AP1G2 Gene

Domains & Families for AP1G2 Gene

Suggested Antigen Peptide Sequences for AP1G2 Gene

Graphical View of Domain Structure for InterPro Entry

O75843

UniProtKB/Swiss-Prot:

AP1G2_HUMAN :
  • Contains 1 GAE domain.
  • Belongs to the adaptor complexes large subunit family.
Domain:
  • Contains 1 GAE domain.
Family:
  • Belongs to the adaptor complexes large subunit family.
genes like me logo Genes that share domains with AP1G2: view

No data available for Gene Families for AP1G2 Gene

Function for AP1G2 Gene

Molecular function for AP1G2 Gene

UniProtKB/Swiss-Prot Function:
May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).

Phenotypes for AP1G2 Gene

genes like me logo Genes that share phenotypes with AP1G2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AP1G2 Gene

Localization for AP1G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1G2 Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Mainly localized to perinuclear vesicular structures (PubMed:9733768). Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments (PubMed:16867982). Colocalizes with HBV major surface antigen L to cis-Golgi-like structures (PubMed:11333915).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AP1G2 Gene COMPARTMENTS Subcellular localization image for AP1G2 gene
Compartment Confidence
golgi apparatus 5
endosome 4
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AP1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005798 Golgi-associated vesicle IDA 9762922
GO:0016020 membrane IDA 9733768
GO:0030121 AP-1 adaptor complex TAS 9733768
GO:0030131 clathrin adaptor complex IEA --
genes like me logo Genes that share ontologies with AP1G2: view

Pathways & Interactions for AP1G2 Gene

genes like me logo Genes that share pathways with AP1G2: view

Pathways by source for AP1G2 Gene

1 GeneGo (Thomson Reuters) pathway for AP1G2 Gene
1 Qiagen pathway for AP1G2 Gene

Gene Ontology (GO) - Biological Process for AP1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0016192 vesicle-mediated transport IEA,NAS 9733768
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with AP1G2: view

No data available for SIGNOR curated interactions for AP1G2 Gene

Drugs & Compounds for AP1G2 Gene

No Compound Related Data Available

Transcripts for AP1G2 Gene

Unigene Clusters for AP1G2 Gene

Adaptor-related protein complex 1, gamma 2 subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AP1G2 Gene

No ASD Table

Relevant External Links for AP1G2 Gene

GeneLoc Exon Structure for
AP1G2
ECgene alternative splicing isoforms for
AP1G2

Expression for AP1G2 Gene

mRNA expression in normal human tissues for AP1G2 Gene

Protein differential expression in normal tissues from HIPED for AP1G2 Gene

This gene is overexpressed in Lymph node (15.5), Peripheral blood mononuclear cells (11.4), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AP1G2 Gene



SOURCE GeneReport for Unigene cluster for AP1G2 Gene Hs.343244

mRNA Expression by UniProt/SwissProt for AP1G2 Gene

O75843-AP1G2_HUMAN
Tissue specificity: Expressed in all but one (skeletal muscle) tissues examined.
genes like me logo Genes that share expression patterns with AP1G2: view

Protein tissue co-expression partners for AP1G2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AP1G2 Gene

Orthologs for AP1G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AP1G2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AP1G2 35
  • 88.47 (n)
  • 89.02 (a)
AP1G2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AP1G2 35
  • 89.31 (n)
  • 90.68 (a)
AP1G2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap1g2 35
  • 86.45 (n)
  • 87.39 (a)
Ap1g2 16
Ap1g2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AP1G2 35
  • 99.7 (n)
  • 99.62 (a)
AP1G2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100362547 35
  • 86.22 (n)
  • 87.5 (a)
oppossum
(Monodelphis domestica)
Mammalia AP1G2 36
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ap1g2 36
  • 55 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta AP-1gamma 37
  • 57 (a)
AP-1gamma 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea apg-1 36
  • 41 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR064C 35
  • 45.88 (n)
  • 36.79 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06579g 35
  • 43.58 (n)
  • 34.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APL4 35
  • 43.51 (n)
  • 35.08 (a)
APL4 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for AP1G2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AP1G2 Gene

ENSEMBL:
Gene Tree for AP1G2 (if available)
TreeFam:
Gene Tree for AP1G2 (if available)

Paralogs for AP1G2 Gene

Paralogs for AP1G2 Gene

(2) SIMAP similar genes for AP1G2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with AP1G2: view

Variants for AP1G2 Gene

Sequence variations from dbSNP and Humsavar for AP1G2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_024363 -

Variation tolerance for AP1G2 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for AP1G2 Gene

Disorders for AP1G2 Gene

Relevant External Links for AP1G2

Genetic Association Database (GAD)
AP1G2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AP1G2

No disorders were found for AP1G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AP1G2 Gene

Publications for AP1G2 Gene

  1. Cloning, expression, and localization of a novel gamma-adaptin-like molecule. (PMID: 9762922) Lewin D.A. … Mellman I. (FEBS Lett. 1998) 2 3 4 23 67
  2. Identification and characterization of novel clathrin adaptor-related proteins. (PMID: 9733768) Takatsu H. … Nakayama K. (J. Biol. Chem. 1998) 2 3 23
  3. gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway. (PMID: 18772139) Rost M. … Prange R. (J. Biol. Chem. 2008) 3 23
  4. Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. (PMID: 12505986) Mattera R. … Bonifacino J.S. (EMBO J. 2003) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for AP1G2 Gene

Sources for AP1G2 Gene

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