Aliases for AP1G2 Gene
External Ids for AP1G2 Gene
Previous GeneCards Identifiers for AP1G2 Gene
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is compsed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. Several alternatively spliced transcript variants of this gene exist, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
GeneCards Summary for AP1G2 Gene
AP1G2 (Adaptor-Related Protein Complex 1, Gamma 2 Subunit) is a Protein Coding gene. Diseases associated with AP1G2 include hiv-1. Among its related pathways are Lysosome and Delta508-CFTR traffic / ER-to-Golgi in CF. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is AP4E1.
UniProtKB/Swiss-Prot for AP1G2 Gene
May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).