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Aliases for AP1G1 Gene

Aliases for AP1G1 Gene

  • Adaptor Related Protein Complex 1 Gamma 1 Subunit 2 3 5
  • Gamma1-Adaptin 2 3 4
  • Clathrin Assembly Protein Complex 1 Gamma-1 Large Chain 3 4
  • Adaptor-Related Protein Complex 1, Gamma 1 Subunit 2 3
  • Adaptor-Related Protein Complex 1 Gamma 1 Subunit 2 3
  • Adaptor-Related Protein Complex 1 Subunit Gamma-1 3 4
  • Golgi Adaptor HA1/AP1 Adaptin Subunit Gamma-1 3 4
  • Adaptor Protein Complex AP-1 Subunit Gamma-1 3 4
  • CLAPG1 3 4
  • ADTG 3 4
  • Clathrin-Associated/Assembly/Adaptor Protein, Large, Gamma 1 3
  • Clathrin Assembly Protein Complex 1 Gamma Large Chain 3
  • Adapter-Related Protein Complex 1 Subunit Gamma-1 3
  • Golgi Adaptor HA1/AP1 Adaptin Gamma Subunit 3
  • Testicular Tissue Protein Li 21 3
  • Gamma Adaptin 3

External Ids for AP1G1 Gene

Previous HGNC Symbols for AP1G1 Gene

  • CLAPG1
  • ADTG

Previous GeneCards Identifiers for AP1G1 Gene

  • GC16M062657
  • GC16M072488
  • GC16M071500
  • GC16M071541
  • GC16M071539
  • GC16M070320
  • GC16M071762
  • GC16M057530

Summaries for AP1G1 Gene

Entrez Gene Summary for AP1G1 Gene

  • Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for AP1G1 Gene

AP1G1 (Adaptor Related Protein Complex 1 Gamma 1 Subunit) is a Protein Coding gene. Diseases associated with AP1G1 include Hypoactive Sexual Desire Disorder. Among its related pathways are CTLA4 Signaling and Clathrin derived vesicle budding. GO annotations related to this gene include binding and Rab GTPase binding. An important paralog of this gene is AP4E1.

UniProtKB/Swiss-Prot for AP1G1 Gene

  • Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Gene Wiki entry for AP1G1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP1G1 Gene

Genomics for AP1G1 Gene

Regulatory Elements for AP1G1 Gene

Enhancers for AP1G1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AP1G1 on UCSC Golden Path with GeneCards custom track

Promoters for AP1G1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AP1G1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AP1G1 Gene

Chromosome:
16
Start:
71,729,000 bp from pter
End:
71,809,201 bp from pter
Size:
80,202 bases
Orientation:
Minus strand

Genomic View for AP1G1 Gene

Genes around AP1G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP1G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP1G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP1G1 Gene

Proteins for AP1G1 Gene

  • Protein details for AP1G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43747-AP1G1_HUMAN
    Recommended name:
    AP-1 complex subunit gamma-1
    Protein Accession:
    O43747
    Secondary Accessions:
    • O75709
    • O75842
    • Q9UG09
    • Q9Y3U4

    Protein attributes for AP1G1 Gene

    Size:
    822 amino acids
    Molecular mass:
    91351 Da
    Quaternary structure:
    • Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds RABEP1 and SYNRG. Interacts (via GAE domain) with AP1AR (via coiled-coil domain).

    Three dimensional structures from OCA and Proteopedia for AP1G1 Gene

    Alternative splice isoforms for AP1G1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP1G1 Gene

Proteomics data for AP1G1 Gene at MOPED

Post-translational modifications for AP1G1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AP1G1 Gene

Domains & Families for AP1G1 Gene

Graphical View of Domain Structure for InterPro Entry

O43747

UniProtKB/Swiss-Prot:

AP1G1_HUMAN :
  • Contains 1 GAE domain.
  • Belongs to the adaptor complexes large subunit family.
Domain:
  • Contains 1 GAE domain.
Family:
  • Belongs to the adaptor complexes large subunit family.
genes like me logo Genes that share domains with AP1G1: view

No data available for Gene Families for AP1G1 Gene

Function for AP1G1 Gene

Molecular function for AP1G1 Gene

UniProtKB/Swiss-Prot Function:
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Gene Ontology (GO) - Molecular Function for AP1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9653655
GO:0005488 binding IEA --
genes like me logo Genes that share ontologies with AP1G1: view
genes like me logo Genes that share phenotypes with AP1G1: view

Animal Models for AP1G1 Gene

MGI Knock Outs for AP1G1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AP1G1 Gene

Localization for AP1G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1G1 Gene

Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AP1G1 Gene COMPARTMENTS Subcellular localization image for AP1G1 gene
Compartment Confidence
cytosol 5
endosome 5
golgi apparatus 5
lysosome 4
vacuole 4
mitochondrion 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AP1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IDA --
GO:0005765 lysosomal membrane TAS --
GO:0030119 AP-type membrane coat adaptor complex TAS 9653655
GO:0030131 clathrin adaptor complex IEA --
genes like me logo Genes that share ontologies with AP1G1: view

Pathways & Interactions for AP1G1 Gene

genes like me logo Genes that share pathways with AP1G1: view

Pathways by source for AP1G1 Gene

1 GeneGo (Thomson Reuters) pathway for AP1G1 Gene
1 Qiagen pathway for AP1G1 Gene

Gene Ontology (GO) - Biological Process for AP1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0016032 viral process TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0032438 melanosome organization IC 22511774
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with AP1G1: view

No data available for SIGNOR curated interactions for AP1G1 Gene

Drugs & Compounds for AP1G1 Gene

(3) Drugs for AP1G1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for AP1G1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with AP1G1: view

Transcripts for AP1G1 Gene

Unigene Clusters for AP1G1 Gene

Adaptor-related protein complex 1, gamma 1 subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AP1G1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: -
SP2: - - - - - - -
SP3:
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - - -
SP9:
SP10: - - -
SP11:
SP12: - -
SP13:

ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b
SP1: - - -
SP2: - - -
SP3: -
SP4: - - - - - - - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for AP1G1 Gene

GeneLoc Exon Structure for
AP1G1
ECgene alternative splicing isoforms for
AP1G1

Expression for AP1G1 Gene

mRNA expression in normal human tissues for AP1G1 Gene

Protein differential expression in normal tissues from HIPED for AP1G1 Gene

This gene is overexpressed in Lymph node (6.1) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AP1G1 Gene



SOURCE GeneReport for Unigene cluster for AP1G1 Gene Hs.461253

mRNA Expression by UniProt/SwissProt for AP1G1 Gene

O43747-AP1G1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with AP1G1: view

Protein tissue co-expression partners for AP1G1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AP1G1 Gene

Orthologs for AP1G1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AP1G1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AP1G1 35
  • 96.12 (n)
  • 99.39 (a)
AP1G1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AP1G1 35
  • 96.48 (n)
  • 99.52 (a)
AP1G1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap1g1 35
  • 93.62 (n)
  • 99.27 (a)
Ap1g1 16
Ap1g1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AP1G1 35
  • 99.88 (n)
  • 100 (a)
AP1G1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ap1g1 35
  • 93.51 (n)
  • 99.03 (a)
oppossum
(Monodelphis domestica)
Mammalia AP1G1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AP1G1 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves AP1G1 35
  • 85.22 (n)
  • 97.08 (a)
AP1G1 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AP1G1 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ap1g1 35
  • 78.69 (n)
  • 91.69 (a)
Str.16162 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6418 35
zebrafish
(Danio rerio)
Actinopterygii ap1g1 35
  • 76.68 (n)
  • 90.11 (a)
wufc30a11 35
ap1g1 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta AP-1gamma 37
  • 60 (a)
AP-1gamma 35
  • 54.86 (n)
  • 57.65 (a)
AP-1gamma 36
  • 46 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008251 35
  • 55.47 (n)
  • 58.91 (a)
worm
(Caenorhabditis elegans)
Secernentea apg-1 35
  • 55.5 (n)
  • 53.05 (a)
apg-1 36
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APL4 36
  • 30 (a)
OneToMany
APL4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons GAMMA-ADAPTIN 1 35
  • 54.32 (n)
  • 48.95 (a)
rice
(Oryza sativa)
Liliopsida Os.4210 35
Os06g0167100 35
  • 54.05 (n)
  • 49.01 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04121 35
  • 51.41 (n)
  • 48.24 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes apl4 35
  • 47.8 (n)
  • 40.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for AP1G1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AP1G1 Gene

ENSEMBL:
Gene Tree for AP1G1 (if available)
TreeFam:
Gene Tree for AP1G1 (if available)

Paralogs for AP1G1 Gene

Paralogs for AP1G1 Gene

genes like me logo Genes that share paralogs with AP1G1: view

Variants for AP1G1 Gene

Sequence variations from dbSNP and Humsavar for AP1G1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs904763 - 71,739,287(-) GCCCC(A/C/G/T)CTTCT reference, missense
rs36037071 - 71,769,681(-) ATCTG(G/T)AGTCC reference, missense
rs3859174 -- 71,806,034(-) ttttt(A/T)ttatt intron-variant
rs3859175 -- 71,806,036(-) TTTTT(A/T)TTTTA intron-variant
rs3933042 -- 71,751,601(+) TAATT(G/T)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AP1G1 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
esv992302 CNV Insertion 20482838
esv1254626 CNV Insertion 17803354
esv2714681 CNV Deletion 23290073
esv2668956 CNV Deletion 23128226

Variation tolerance for AP1G1 Gene

Residual Variation Intolerance Score: 5.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.31; 88.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AP1G1 Gene

Disorders for AP1G1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AP1G1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypoactive sexual desire disorder
  • lack or loss of sexual desire
- elite association - COSMIC cancer census association via MalaCards
Search AP1G1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AP1G1

Genetic Association Database (GAD)
AP1G1
Human Genome Epidemiology (HuGE) Navigator
AP1G1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AP1G1
genes like me logo Genes that share disorders with AP1G1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AP1G1 Gene

Publications for AP1G1 Gene

  1. Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG). (PMID: 9653655) Peyrard M. … Dumanski J.P. (Genomics 1998) 2 3 4 23 67
  2. Identification and characterization of novel clathrin adaptor-related proteins. (PMID: 9733768) Takatsu H. … Nakayama K. (J. Biol. Chem. 1998) 2 3 23
  3. Definition of the consensus motif recognized by gamma-adaptin ear domains. (PMID: 14665628) Mattera R. … Bonifacino J.S. (J. Biol. Chem. 2004) 3 23
  4. The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites. (PMID: 15143060) Mattera R. … Bonifacino J.S. (J. Biol. Chem. 2004) 3 23
  5. Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. (PMID: 12505986) Mattera R. … Bonifacino J.S. (EMBO J. 2003) 3 23

Products for AP1G1 Gene

Sources for AP1G1 Gene

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