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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AP1G1 Gene

protein-coding   GIFtS: 64
GCID: GC16M071762

Adaptor-Related Protein Complex 1, Gamma 1 Subunit


(Previous symbols: CLAPG1, ADTG)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adaptor-Related Protein Complex 1, Gamma 1 Subunit1 2     Golgi Adaptor HA1/AP1 Adaptin Subunit Gamma-12 3
ADTG1 2 3 5     AP-1 Complex Subunit Gamma-12
CLAPG11 2 3 5     Clathrin Assembly Protein Complex 1 Gamma Large Chain2
gamma1-adaptin1 2     Clathrin-Associated/Assembly/Adaptor Protein, Large, Gamma 12
Adapter-Related Protein Complex 1 Subunit Gamma-12 3     Gamma Adaptin2
Adaptor Protein Complex AP-1 Subunit Gamma-12 3     Golgi Adaptor HA1/AP1 Adaptin Gamma Subunit2
Clathrin Assembly Protein Complex 1 Gamma-1 Large Chain2 3     Gamma1-adaptin3

External Ids:    HGNC: 5551   Entrez Gene: 1642   Ensembl: ENSG000001667477   OMIM: 6035335   UniProtKB: O437473   

Export aliases for AP1G1 gene to outside databases

Previous GC identifers: GC16M062657 GC16M072488 GC16M071500 GC16M071541 GC16M071539 GC16M070320 GC16M057530


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AP1G1 Gene:
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the
plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four
classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and
small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of
clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to
the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for AP1G1 Gene: 
AP1G1 (adaptor-related protein complex 1, gamma 1 subunit) is a protein-coding gene. Diseases associated with AP1G1 include hypoactive sexual desire disorder, and hiv type 1, and among its related super-pathways are Clathrin-dependent protein traffic and Clathrin derived vesicle budding. GO annotations related to this gene include transporter activity and kinesin binding. An important paralog of this gene is AP1G2.

UniProtKB/Swiss-Prot: AP1G1_HUMAN, O43747
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the
late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin
to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

Gene Wiki entry for AP1G1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AP1G1 gene promoter:
         E2F-3a   E2F-1   E2F   AP-1   ATF-2   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAP1G1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AP1G1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP1G1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q23

AP1G1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP1G1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M071762:  view genomic region     (about GC identifiers)

Start:
71,762,903 bp from pter      End:
71,843,104 bp from pter
Size:
80,202 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AP1G1_HUMAN, O43747 (See protein sequence)
Recommended Name: AP-1 complex subunit gamma-1  
Size: 822 amino acids; 91351 Da
Subunit: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit
AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin
(sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds RABEP1 and SYNRG. Interacts (via GAE domain) with AP1AR (via
coiled-coil domain)
Subcellular location: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane
protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located
at the Golgi complex
1 PDB 3D structure from and Proteopedia for AP1G1:
1IU1 (3D)    
Secondary accessions: O75709 O75842 Q9UG09 Q9Y3U4
Alternative splicing: 2 isoforms:  O43747-1   O43747-2   

Explore the universe of human proteins at neXtProt for AP1G1: NX_O43747

Explore proteomics data for AP1G1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43747

  • AP1G1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AP1G1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001025178.1  NP_001119.3  

    ENSEMBL proteins: 
     ENSP00000299980   ENSP00000454219   ENSP00000454523   ENSP00000377148   ENSP00000457726  
     ENSP00000454970   ENSP00000454932   ENSP00000405836   ENSP00000456058   ENSP00000454713  
     ENSP00000456316   ENSP00000457927   ENSP00000456493   ENSP00000454717   ENSP00000455400  
     ENSP00000403259   ENSP00000409153  
    Reactome Protein details: O43747
    Human Recombinant Protein Products for AP1G1: 
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    Novus Biologicals AP1G1 Protein
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005737cytoplasm TAS9733768
    GO:0005765lysosomal membrane TAS--
    GO:0005794Golgi apparatus IDA9733768
    GO:0005802trans-Golgi network ----

    AP1G1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR008152 Clathrin_a/b/g-adaptin_app_Ig
     IPR017107 AP1_complex_gsu
     IPR011989 ARM-like
     IPR008153 Clathrin_g-adaptin_app
     IPR002553 Clathrin/coatomer_adapt-like_N

    Graphical View of Domain Structure for InterPro Entry O43747

    ProtoNet protein and cluster: O43747

    3 Blocks protein domains:
    IPB002553 Adaptin
    IPB008152 Alpha/gamma adaptin
    IPB008153 Gamma-adaptin


    UniProtKB/Swiss-Prot: AP1G1_HUMAN, O43747
    Similarity: Belongs to the adaptor complexes large subunit family
    Similarity: Contains 1 GAE domain


    AP1G1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP1G1_HUMAN, O43747
    Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the
    late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin
    to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS9653655
    GO:0005488binding ----
    GO:0005515protein binding IPI12505986
    GO:0008565protein transporter activity IEA--
    GO:0019894kinesin binding IPI19841138
         
    AP1G1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AP1G1:
     Increased G2M DNA content  Increased cell size 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ap1g1):
     growth/size  hematopoietic system  immune system  mortality/aging 

    AP1G1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ap1g1tm1Schu for AP1G1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AP1G1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AP1G1 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic0.66
    Transport Clathrin-coated vesicle cycle0.66
    2Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Lysosome Vesicle Biogenesis0.39
    3Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
    Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters0.75
    Nef mediated downregulation of MHC class I complex cell surface expression0.48
    The role of Nef in HIV-1 replication and disease pathogenesis0.75
    4HIV Life Cycle
    HIV Infection0.61
    Host Interactions of HIV factors0.60
    5Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for AP1G1
        Clathrin-dependent protein traffic

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AP1G1
        CTLA4 Signaling

    1 GeneGo (Thomson Reuters) Pathway for AP1G1
        Transport Clathrin-coated vesicle cycle

    5/14        Reactome Pathways for AP1G1 (see all 14)
        Membrane Trafficking
    Clathrin derived vesicle budding
    trans-Golgi Network Vesicle Budding
    Adaptive Immune System
    Lysosome Vesicle Biogenesis


    1         Kegg Pathway  (Kegg details for AP1G1):
        Lysosome


    AP1G1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AP1G1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/136 Interacting proteins for AP1G1 (O437471, 2, 3 ENSP000003771484) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BICD1Q96G012, 3, ENSP000002814744MINT-4049907 I2D: score=1 STRING: ENSP00000281474
    PACS1Q6VY072, 3, ENSP000003164544MINT-3372236 I2D: score=1 STRING: ENSP00000316454
    RAB14P611062, 3, ENSP000003629464MINT-3369736 I2D: score=1 STRING: ENSP00000362946
    RABEP1Q152761, 3, ENSP000002624774EBI-447609,EBI-447043 I2D: score=4 STRING: ENSP00000262477
    AP2B1P630103, ENSP000003144144I2D: score=9 STRING: ENSP00000314414
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0006897endocytosis IEA--
    GO:0015031protein transport ----
    GO:0016032viral process TAS--

    AP1G1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AP1G1 for compounds           About GeneDecksing

    EMD Millipore small molecules for AP1G1:
    Small Molecule - inhibitor
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    Browse Tocris compounds for AP1G1

    5 Novoseek inferred chemical compound relationships for AP1G1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 80.6 4 9668075 (2), 9389793 (1), 10473634 (1)
    propanil 66.4 1 15047686 (1)
    wortmannin 24.6 1 9305867 (1)
    phenylalanine 13.8 1 17506864 (1)
    alanine 7.85 1 9725807 (1)

    Search CenterWatch for drugs/clinical trials and news about AP1G1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AP1G1 gene (2 alternative transcripts): 
    NM_001030007.1  NM_001128.5  

    Unigene Cluster for AP1G1:

    Adaptor-related protein complex 1, gamma 1 subunit
    Hs.461253  [show with all ESTs]
    Unigene Representative Sequence: NM_001030007
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000299980(uc002faz.3 uc021tky.1 uc021tkz.1 uc010cgg.3 uc002fbb.3)
    ENST00000564155 ENST00000569748(uc010vmh.1) ENST00000570052 ENST00000393512(uc010vmg.1)
    ENST00000565009 ENST00000565642 ENST00000562934 ENST00000568327 ENST00000566179
    ENST00000569044 ENST00000450149 ENST00000563259 ENST00000563104 ENST00000569185
    ENST00000566161 ENST00000567583 ENST00000565412
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB015317.1 AK025020.1 AK128078.1 AK225906.1 AK293233.1 AK294546.1 AK299630.1 AK314484.1 
    AL110198.1 BC003414.1 BC036283.1 BC051747.1 Y12226.1 

    21 DOTS entries:

    DT.101960211  DT.446874  DT.100784009  DT.95122479  DT.91683606  DT.95217459  DT.99999023  DT.100676673 
    DT.100682801  DT.120663855  DT.40115213  DT.75144128  DT.91818456  DT.92052110  DT.95217490  DT.120663803 
    DT.91683941  DT.91787915  DT.95091723  DT.101969870  DT.95217475 

    24/277 AceView cDNA sequences (see all 277):

    BX106751 AI880703 BI826760 BM834795 BU153233 NM_001128 AL045231 AA406103 
    AK128078 AA860313 AW956657 AB015317 BI522853 BP359358 BM694030 BM850188 
    AA382628 AI805479 AW440748 AA987620 AI800227 BQ889490 BF059254 AI830048 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for AP1G1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^
    SP1:                                -                                                                                                                           
    SP2:                                -     -     -     -     -     -     -                                                                                       
    SP3:                                                                                                                                                            
    SP4:                                -     -     -     -     -     -     -                       -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                -           -     -     -     -     -                                                                                       

    ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b
    SP1:                    -                             -                             -                                       
    SP2:                    -                             -                             -                                       
    SP3:                                                                                -                                       
    SP4:  -     -     -     -     -     -     -     -     -     -     -     -           -                                       
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for AP1G1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AP1G1 expression in normal human tissues (normalized intensities)      AP1G1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AP1G1 Expression
    About this image


    AP1G1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
             sperm   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             lung ; pneumocytes   
             trachea   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See AP1G1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AP1G1

    SOURCE GeneReport for Unigene cluster: Hs.461253

    UniProtKB/Swiss-Prot: AP1G1_HUMAN, O43747
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for AP1G1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AP1G1 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ap1g11 , 5 adaptor protein complex AP-1, gamma 1 subunit1, 5 93.59(n)1
    99.27(a)1
      8 (57.26 cM)5
    117651  NM_009677.51  NP_033807.21 
     1097785545 
    chicken
    (Gallus gallus)
    Aves AP1G11 adaptor-related protein complex 1, gamma 1 subunit 85.33(n)
    97.31(a)
      415880  NM_001006132.1  NP_001006132.1 
    lizard
    (Anolis carolinensis)
    Reptilia AP1G16
    adaptor-related protein complex 1, gamma 1 subunit...
    94(a)
    1 ↔ 1
    GL343483.1(301317-310631)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.64182 Xenopus laevis, Similar to adaptor protein complex more 79.88(n)    BC045070.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc30a112 wufc30a11 78.37(n)   324466  BC047823.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AP-1&ggr;3
    AP-1gamma1
    non-selective vesicle coating3
    AP-1gamma1
    60(a)3
    55.29(n)1
    57.48(a)1
      8C93
    318421  NM_176717.31  NP_788890.21 
    worm
    (Caenorhabditis elegans)
    Secernentea apg-11 Protein APG-1 55.53(n)
    53.62(a)
      173304  NM_170941.5  NP_740937.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APL4(YPR029C)4 Gamma-adaptin, large subunit of the clathrin-associated more   --   16(626967-624469) 856141  NP_015354.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GAMMA-ADAPTIN 11 AP-1 complex subunit gamma-1 54.22(n)
    48.95(a)
      839001  NM_179370.3  NP_849701.1 
    rice
    (Oryza sativa)
    Liliopsida Os.42102 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.03(n)    AK101686.1 


    ENSEMBL Gene Tree for AP1G1 (if available)
    TreeFam Gene Tree for AP1G1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AP1G1 gene
    AP1G22  AP4E12  
    3 SIMAP similar genes for AP1G1 using alignment to 17 protein entries:     AP1G1_HUMAN (see all proteins):
    AP1G2    AP2A2    AP4E1

    AP1G1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1700 SNPs in AP1G1 are shown (see all 1700)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471655481,2
    --71762420(+) TCCAAC/TTGCAC 2 -- ds50010--------
    rs1893203901,2
    --71762446(+) TGTCTA/GTAACA 2 -- ds50010--------
    rs777921461,2
    C,F--71762455(+) CACAAG/CTTTGT 2 -- ds50012Minor allele frequency- C:0.12NA EA 240
    rs1823698661,2
    --71762474(+) TTGTTC/TTTGAG 2 -- ds50010--------
    rs1391399351,2
    C--71762494(+) CACTC-/TTGTCAC 2 -- ds50010--------
    rs1385528511,2
    --71762521(+) AATGGC/TGTGAT 2 -- ds50010--------
    rs602360551,2
    C--71762703(+) GATCCA/GCCCAC 2 -- ds50010--------
    rs133372241,2
    C,F--71762738(+) tacagG/Ccgtga 2 -- ds50012Minor allele frequency- C:0.50WA 4
    rs1874245631,2
    --71762740(+) CAGGCA/GTGAGC 2 -- ds50010--------
    rs1894686861,2
    --71762780(+) ATTCAA/GATTCC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for AP1G1 (71762903 - 71843104 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for AP1G1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2714681CNV Deletion23290073
    esv2668956CNV Deletion23128226
    esv992302CNV Insertion20482838
    esv1254626CNV Insertion17803354
    nsv7285OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603533    OMIM disorders: --

    8 diseases for AP1G1:    About MalaCards
    hypoactive sexual desire disorder    hiv type 1    myopathy    colon cancer
    hepatitis b    hepatitis    pancreatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for AP1G1:
    Hypoactive sexual desire disorder

    AP1G1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AP1G1
    Human Genome Epidemiology (HuGE) Navigator: AP1G1 (1 document)

    Export disorders for AP1G1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AP1G1 gene, integrated from 9 sources (see all 120):
    (articles sorted by number of sources associating them with AP1G1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG). (PubMed id 9653655)1, 2, 3, 9 Peyrard M.... Dumanski J.P. (1998)
    2. Identification and characterization of novel clathrin adaptor-related proteins. (PubMed id 9733768)1, 2, 3, 9 Takatsu H.... Nakayama K. (1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking. (PubMed id 15775984)1, 2 Neubrand V.E.... Simpson J.C. (2005)
    5. Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes. (PubMed id 12773381)1, 2 Deneka M.... van der Sluijs P. (2003)
    6. Structural basis for the accessory protein recruitment by the gamma- adaptin ear domain. (PubMed id 12042876)1, 2 Nogi T.... Wakatsuki S. (2002)
    7. Definition of the consensus motif recognized by gamma-adaptin ear domains. (PubMed id 14665628)1, 9 Mattera R.... Bonifacino J.S. (2004)
    8. The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites. (PubMed id 15143060)1, 9 Mattera R.... Bonifacino J.S. (2004)
    9. Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. (PubMed id 12505986)1, 9 Mattera R.... Bonifacino J.S. (2003)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 164 HGNC: 555 AceView: AP1G1 Ensembl:ENSG00000166747 euGenes: HUgn164
    ECgene: AP1G1 Kegg: 164 H-InvDB: AP1G1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AP1G1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AP1G1 gene:
    Search GeneIP for patents involving AP1G1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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