AP1G1 Gene
protein-coding GIFtS: 61
GCID: GC16M071762
|
|
adaptor-related protein complex 1, gamma 1 subunit
(Previous symbols: CLAPG1, ADTG)
| |
Aliases
for AP1G1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adaptor-Related Protein Complex 1, Gamma 1 Subunit1 2 | | AP-1 Complex Subunit Gamma-12 | | ADTG1 2 3 5 | | Clathrin Assembly Protein Complex 1 Gamma Large Chain2 | | CLAPG11 2 3 5 | | Clathrin-Associated/Assembly/Adaptor Protein, Large, Gamma 12 | | Adapter-Related Protein Complex 1 Subunit Gamma-12 3 | | Gamma Adaptin2 | | Adaptor Protein Complex AP-1 Subunit Gamma-12 3 | | Gamma1-Adaptin1 | | Clathrin Assembly Protein Complex 1 Gamma-1 Large Chain2 3 | | Golgi Adaptor HA1/AP1 Adaptin Gamma Subunit2 | | Golgi Adaptor HA1/AP1 Adaptin Subunit Gamma-12 3 | | Gamma1-Adaptin1 |
Export aliases for AP1G1 gene to outside databasesPrevious GC identifers: GC16M062657 GC16M072488 GC16M071500 GC16M071541 GC16M071539 GC16M070320 GC16M057530 |
Summaries
for AP1G1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AP1G1:
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasmamembrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes ofmolecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, forma heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits andvesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes largesubunits family. Two transcript variants encoding different isoforms have been found for this gene. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: AP1G1_HUMAN, O43747Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in thelate-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin tomembranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules
Gene Wiki entry for AP1G1
|
Genomic Views
for AP1G1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AP1G1 gene promoter:
E2F-3a E2F-1 E2F AP-1 ATF-2 E2F-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for AP1G1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP1G1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q23 Ensembl cytogenetic band: 16q22.2 HGNC cytogenetic band: 16q23AP1G1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M071762: view genomic region
(about GC identifiers)
Start:
|
71,762,903 bp from pter |
End:
|
71,843,104 bp from pter |
Size:
|
80,202 bases |
Orientation:
|
minus strand |
|
Proteins
for AP1G1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AP1G1_HUMAN, O43747 (See
protein sequence)Recommended Name: AP-1 complex subunit gamma-1 Size: 822 amino acids; 91351 Da
Subunit: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-typesubunit AP1S1 or AP1S2 or AP1S3). Binds RABEP1 and SYNRG. Interacts (via GAE domain) with AP1AR (via coiled-coildomain)
Subcellular location: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membraneprotein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located atthe Golgi complex
1 PDB 3D structure from  and Proteopedia  for AP1G1:1IU1 (3D)
Secondary accessions: O75709 O75842 Q9UG09 Q9Y3U4Alternative splicing: 2 isoforms: O43747-1 O43747-2 Explore the universe of human proteins at neXtProt for AP1G1: NX_O43747
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43747
AP1G1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001025178.1 NP_001119.3
ENSEMBL proteins: ENSP00000299980 ENSP00000454219 ENSP00000454523 ENSP00000377148 ENSP00000457726 ENSP00000454970 ENSP00000454932 ENSP00000405836 ENSP00000456058 ENSP00000454713 ENSP00000456316 ENSP00000457927 ENSP00000456493 ENSP00000454717 ENSP00000455400 ENSP00000403259 ENSP00000409153 Reactome Protein details: O43747
Human Recombinant Protein Products:
Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16): About this table
AP1G1 for ontologies About GeneDecksing
AP1G1 Antibody Products:
Assay Products for AP1G1: |
Protein
Domains /
Families
for AP1G1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AP1G1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry O43747ProtoNet protein and cluster: O43747 3 Blocks protein families: IPB002553 Adaptin IPB008152 Alpha/gamma adaptin IPB008153 Gamma-adaptin
UniProtKB/Swiss-Prot: AP1G1_HUMAN, O43747Similarity: Belongs to the adaptor complexes large subunit familySimilarity: Contains 1 GAE domain |
Function
for AP1G1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AP1G1_HUMAN, O43747Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in thelate-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin tomembranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP1G1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP1G1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): AP1G1 (NM_001128) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP1G1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP1G1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1G1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
AP1G1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for AP1G1:
Animal Models:
Mouse knock-out Ap1g1tm1Schu for AP1G1
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ap1g1):
AP1G1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for AP1G1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Clathrin derived vesicle budding | | | 2 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | | | 3 | Clathrin-dependent protein traffic | | | 4 | Immune System | | | 5 | HIV Infection | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for AP1G1
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AP1G1
1  GeneGo (Thomson Reuters) Pathway for AP1G1
5/15 
Reactome Pathways for AP1G1 (see all 15)
1 
Kegg Pathway (Kegg details for AP1G1):
AP1G1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AP1G1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/136 Interacting proteins for AP1G1 (O437471, 2, 3 ENSP000003771484) via UniProtKB, MINT, STRING, and/or I2D (see all 136)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| BICD1 | Q96G012, 3, ENSP000002814744 | MINT-4049907 I2D:
score=1 STRING: ENSP00000281474 | | PACS1 | Q6VY072, 3, ENSP000003164544 | MINT-3372236 I2D:
score=1 STRING: ENSP00000316454 | | RAB14 | P611062, 3, ENSP000003629464 | MINT-3369736 I2D:
score=1 STRING: ENSP00000362946 | | RABEP1 | Q152761, 3, ENSP000002624774 | EBI-447609,EBI-447043 I2D:
score=4 STRING: ENSP00000262477 | | AP2B1 | P630103, ENSP000003144144 | I2D:
score=9 STRING: ENSP00000314414 |
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
AP1G1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AP1G1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
AP1G1 for compounds About GeneDecksing
 Browse Tocris compounds for AP1G1
5 Novoseek chemical compound relationships for AP1G1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mannose 6-phosphate |
80.6 |
4 |
9668075 (2), 9389793 (1), 10473634 (1) |
| propanil |
66.4 |
1 |
15047686 (1) |
| wortmannin |
24.6 |
1 |
9305867 (1) |
| phenylalanine |
13.8 |
1 |
17506864 (1) |
| alanine |
7.85 |
1 |
9725807 (1) |
Search CenterWatch for drugs/clinical trials and news about AP1G1
|
Transcripts
for AP1G1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AP1G1 gene (2 alternative transcripts): NM_001030007.1 NM_001128.5 Unigene Cluster for AP1G1: Adaptor-related protein complex 1, gamma 1 subunit Hs.461253 [show with all ESTs]Unigene Representative Sequence: NM_00103000718/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24): ENST00000299980(uc002faz.3 uc021tky.1 uc021tkz.1 uc010cgg.3 uc002fbb.3)
ENST00000564155 ENST00000569748(uc010vmh.1) ENST00000570052 ENST00000393512(uc010vmg.1)
ENST00000565009 ENST00000565642 ENST00000562934 ENST00000568327 ENST00000566179
ENST00000569044 ENST00000450149 ENST00000563259 ENST00000563104 ENST00000569185
ENST00000566161 ENST00000567583 ENST00000565412
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP1G1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP1G1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): AP1G1 (NM_001128) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP1G1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP1G1 |
Additional cDNA sequence: AB015317.1 AK025020.1 AK128078.1 AK225906.1 AK293233.1 AK294546.1 AK299630.1 AK314484.1 AL110198.1 BC003414.1 BC036283.1 BC051747.1 Y12226.1 21 DOTS entries: DT.101960211 DT.446874 DT.100784009 DT.95122479 DT.91683606 DT.95217459 DT.100676673 DT.100682801 DT.120663855 DT.40115213 DT.75144128 DT.91818456 DT.92052110 DT.95217490 DT.99999023 DT.120663803 DT.91683941 DT.91787915 DT.95091723 DT.101969870 DT.95217475 24/277 AceView cDNA sequences (see all 277): AA789113 AL110198 AI554743 AA406105 BM818338 AA987620 AI800227 BM843158 AA382628 BP365891 AK128078 BQ889490 BI826760 AA557623 AA993707 BX362296 AL045231 AA923267 AA700372 BM824288 BM694030 BI766972 AW440748 AA352876
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for AP1G1 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP5: | | | | | | | | | | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for AP1G1
|
Expression
for AP1G1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AP1G1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See AP1G1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AP1G1
SOURCE GeneReport for Unigene cluster: Hs.461253
UniProtKB/Swiss-Prot: AP1G1_HUMAN, O43747Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for AP1G1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP1G1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AP1G1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP1G1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP1G1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1G1 |
Orthologs
for AP1G1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for AP1G1 gene from 8/32 species (see all 32) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
AP1G11 |
adaptor-related protein complex 1, gamma 1 subunit |
85.33(n)
97.31(a) |
|
415880 NM_001006132.1 NP_001006132.1 |
lizard
(Anolis carolinensis) |
Reptilia |
AP1G16 |
-- |
91(a) |
1 ↔ 1 |
GL343483.1(301317-306389) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.64182 |
Xenopus laevis, Similar to adaptor protein complex more |
79.88(n) |
|
BC045070.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc30a112 |
wufc30a11 |
78.37(n) |
|
324466 BC047823.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
AP-1&ggr;3
AP-1gamma1 |
non-selective vesicle coating3
AP-1gamma1 |
60(a)3
55.29(n)1
57.48(a)1 |
|
8C93
318421 NM_176717.31 NP_788890.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
apg-11 |
Protein APG-1 |
55.53(n)
53.62(a) |
|
173304 NM_170941.5 NP_740937.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
GAMMA-ADAPTIN 11 |
AP-1 complex subunit gamma-1 |
54.22(n)
48.95(a) |
|
839001 NM_179370.3 NP_849701.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.42102 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
72.03(n) |
|
AK101686.1 |
ENSEMBL Gene Tree for AP1G1 (if available)
TreeFam Gene Tree for AP1G1 (if available) |
Paralogs
for AP1G1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AP1G1 gene
- AP1G22 AP4E12
3 SIMAP similar genes for AP1G1 using alignment to 17 protein entries: AP1G1_HUMAN (see all proteins):AP1G2 AP2A2 AP4E1
AP1G1 for paralogs About GeneDecksing
|
Genomic Variants
for AP1G1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AP1G1 (71762903 - 71843104 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AP1G1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AP1G1 |
|
Disorders
/ Diseases
for AP1G1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AP1G1 for disorders About GeneDecksing
OMIM gene information: 603533
OMIM disorders: --
10  diseases for AP1G1: About MalaCardshepatitis b colon carcinoma colon cancer myopathy
hepatitis immunodeficiency carcinoma pancreatitis
malaria neuronitis
1 disease from the University of Copenhagen DISEASES database for AP1G1:Hypoactive sexual desire disorder Human Genome Epidemiology (HuGE) Navigator: AP1G1 (1 document)
Export disorders for AP1G1 gene to outside databases
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Publications
for AP1G1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for AP1G1 gene, integrated from 9 sources (see all 119):
(articles sorted by number of sources associating them with AP1G1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG). (PubMed id 9653655)1, 2, 3, 9 Peyrard M.... Dumanski J.P. (1998)
- Identification and characterization of novel clathrin adaptor-related proteins. (PubMed id 9733768)1, 2, 3, 9 Takatsu H.... Nakayama K. (1998)
- Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking. (PubMed id 15775984)1, 2 Neubrand V.E.... Simpson J.C. (2005)
- Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes. (PubMed id 12773381)1, 2 Deneka M.... van der Sluijs P. (2003)
- Structural basis for the accessory protein recruitment by the gamma- adaptin ear domain. (PubMed id 12042876)1, 2 Nogi T.... Wakatsuki S. (2002)
- Definition of the consensus motif recognized by gamma-adaptin ear domains. (PubMed id 14665628)1, 9 Mattera R.... Bonifacino J.S. (2004)
- The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites. (PubMed id 15143060)1, 9 Mattera R.... Bonifacino J.S. (2004)
- Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. (PubMed id 12505986)1, 9 Mattera R.... Bonifacino J.S. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
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External Searches for AP1G1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing AP1G1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing AP1G1 gene
(According to HUGE)
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Specialized Databases showing AP1G1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for AP1G1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for AP1G1 gene:
Search GeneIP for patents involving AP1G1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for AP1G1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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