Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AP1G1 Gene

protein-coding   GIFtS: 64
GCID: GC16M071762

Adaptor-Related Protein Complex 1, Gamma 1 Subunit


(Previous symbols: CLAPG1, ADTG)
  See AP1G1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Adaptor-Related Protein Complex 1, Gamma 1 Subunit1 2     Golgi Adaptor HA1/AP1 Adaptin Subunit Gamma-12 3
ADTG1 2 3 5     AP-1 Complex Subunit Gamma-12
CLAPG11 2 3 5     Clathrin Assembly Protein Complex 1 Gamma Large Chain2
gamma1-adaptin1 2     Clathrin-Associated/Assembly/Adaptor Protein, Large, Gamma 12
Adapter-Related Protein Complex 1 Subunit Gamma-12 3     Gamma Adaptin2
Adaptor Protein Complex AP-1 Subunit Gamma-12 3     Golgi Adaptor HA1/AP1 Adaptin Gamma Subunit2
Clathrin Assembly Protein Complex 1 Gamma-1 Large Chain2 3     Gamma1-adaptin3

External Ids:    HGNC: 5551   Entrez Gene: 1642   Ensembl: ENSG000001667477   OMIM: 6035335   UniProtKB: O437473   

Export aliases for AP1G1 gene to outside databases

Previous GC identifers: GC16M062657 GC16M072488 GC16M071500 GC16M071541 GC16M071539 GC16M070320 GC16M057530


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for AP1G1 Gene:
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the
plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four
classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and
small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of
clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to
the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for AP1G1 Gene:
AP1G1 (adaptor-related protein complex 1, gamma 1 subunit) is a protein-coding gene. Diseases associated with AP1G1 include hypoactive sexual desire disorder. GO annotations related to this gene include transporter activity and kinesin binding. An important paralog of this gene is AP1G2.

UniProtKB/Swiss-Prot: AP1G1_HUMAN, O43747
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the
late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin
to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

Gene Wiki entry for AP1G1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the AP1G1 gene promoter:
         E2F-3a   E2F-1   E2F   AP-1   ATF-2   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAP1G1 promoter sequence
   Search Chromatin IP Primers for AP1G1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AP1G1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q23

AP1G1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP1G1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M071762:  view genomic region     (about GC identifiers)

Start:
71,762,903 bp from pter      End:
71,843,104 bp from pter
Size:
80,202 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AP1G1_HUMAN, O43747 (See protein sequence)
Recommended Name: AP-1 complex subunit gamma-1  
Size: 822 amino acids; 91351 Da
Subunit: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit
AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin
(sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds RABEP1 and SYNRG. Interacts (via GAE domain) with AP1AR (via
coiled-coil domain)
1 PDB 3D structure from and Proteopedia for AP1G1:
1IU1 (3D)    
Secondary accessions: O75709 O75842 Q9UG09 Q9Y3U4
Alternative splicing: 2 isoforms:  O43747-1   O43747-2   

Explore the universe of human proteins at neXtProt for AP1G1: NX_O43747

Explore proteomics data for AP1G1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AP1G1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001025178.1  NP_001119.3  

    ENSEMBL proteins: 
     ENSP00000299980   ENSP00000454219   ENSP00000454523   ENSP00000377148   ENSP00000457726  
     ENSP00000454970   ENSP00000454932   ENSP00000405836   ENSP00000456058   ENSP00000454713  
     ENSP00000456316   ENSP00000457927   ENSP00000456493   ENSP00000454717   ENSP00000455400  
     ENSP00000403259   ENSP00000409153  
    Reactome Protein details: O43747

    AP1G1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for AP1G1
    OriGene Protein Over-expression Lysate for AP1G1
    OriGene MassSpec for AP1G1
    OriGene Custom Protein Services for AP1G1
    GenScript Custom Purified and Recombinant Proteins Services for AP1G1
    Novus Biologicals AP1G1 Protein
    Novus Biologicals AP1G1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for AP1G1 

    AP1G1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for AP1G1
    OriGene Custom Antibody Services for AP1G1
    Novus Biologicals AP1G1 Antibodies
    Abcam antibodies for AP1G1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for AP1G1
    LSBio Antibodies in human, mouse, rat for AP1G1

    AP1G1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AP1G1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AP1G1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for AP1G1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 7):
     IPR017107 AP1_complex_gsu
     IPR011989 ARM-like
     IPR002553 Clathrin/coatomer_adapt-like_N
     IPR013041 Coatomer/clathrin_app_Ig-like
     IPR008152 Clathrin_a/b/g-adaptin_app_Ig

    Graphical View of Domain Structure for InterPro Entry O43747

    ProtoNet protein and cluster: O43747

    3 Blocks protein domains:
    IPB002553 Adaptin
    IPB008152 Alpha/gamma adaptin
    IPB008153 Gamma-adaptin


    UniProtKB/Swiss-Prot: AP1G1_HUMAN, O43747
    Similarity: Belongs to the adaptor complexes large subunit family
    Similarity: Contains 1 GAE domain


    Find genes that share domains with AP1G1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP1G1_HUMAN, O43747
    Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the
    late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin
    to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS9653655
    GO:0005488binding ----
    GO:0005515protein binding IPI12505986
    GO:0008565protein transporter activity IEA--
    GO:0019894kinesin binding IPI19841138
         
    Find genes that share ontologies with AP1G1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for AP1G1:
     Increased G2M DNA content  Increased cell size 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ap1g1):
     growth/size/body  hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with AP1G1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ap1g1tm1Schu for AP1G1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AP1G1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AP1G1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AP1G1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AP1G1

    miRNA
    Products:
        
    miRTarBase miRNAs that target AP1G1:
    hsa-mir-652-3p (MIRT039485), hsa-mir-145-5p (MIRT021529), hsa-mir-101-3p (MIRT027293), hsa-mir-186-5p (MIRT021107), hsa-mir-106b-5p (MIRT044261), hsa-mir-155-5p (MIRT020626), hsa-mir-484 (MIRT041995), hsa-mir-93-5p (MIRT027948)

    Block miRNA regulation of human, mouse, rat AP1G1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AP1G1 (see all 45):
    hsa-miR-548k hsa-miR-29a hsa-miR-371-5p hsa-miR-519a hsa-miR-124 hsa-miR-3150b-3p hsa-miR-3613-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidAP1G1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AP1G1
    Predesigned siRNA for gene silencing in human, mouse, rat AP1G1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AP1G1

    Clone
    Products:
         
    OriGene clones in human, mouse for AP1G1 (see all 12)
    OriGene ORF clones in mouse, rat for AP1G1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AP1G1 (NM_001128)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AP1G1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP1G1
    Addgene plasmids for AP1G1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AP1G1
    Browse ESI BIO Cell Lines and PureStem Progenitors for AP1G1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1G1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AP1G1_HUMAN, O43747: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane
    protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located
    at the Golgi complex
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    golgi apparatus5
    cytosol4
    lysosome4
    vacuole4
    mitochondrion2
    nucleus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005737cytoplasm IDA--
    GO:0005765lysosomal membrane TAS--
    GO:0005794Golgi apparatus IDA9733768
    GO:0005802trans-Golgi network ----

    Find genes that share ontologies with AP1G1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AP1G1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    Transport Clathrin coated vesicle cycle0.66
    2Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    Lysosome Vesicle Biogenesis0.41
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32
    trans-Golgi Network Vesicle Budding0.89
    3Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
    Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters0.76
    Nef mediated downregulation of MHC class I complex cell surface expression0.00
    The role of Nef in HIV-1 replication and disease pathogenesis0.76
    4HIV Life Cycle
    HIV Infection0.62
    Host Interactions of HIV factors0.60
    5Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41


    Find genes that share SuperPaths with AP1G1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AP1G1
        CTLA4 Signaling

    1 GeneGo (Thomson Reuters) Pathway for AP1G1
        Transport Clathrin-coated vesicle cycle

    4 Reactome Pathways for AP1G1
        Golgi Associated Vesicle Biogenesis
    Lysosome Vesicle Biogenesis
    Nef mediated downregulation of MHC class I complex cell surface expression
    MHC class II antigen presentation


    1 Kegg Pathway  (Kegg details for AP1G1):
        Lysosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AP1G1
    Interactions:

        GeneGlobe Interaction Network for AP1G1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AP1G1 (O437471, 2, 3 ENSP000003771484) via UniProtKB, MINT, STRING, and/or I2D (see all 166)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BICD1Q96G012, 3, ENSP000002814744MINT-4049907 I2D: score=1 STRING: ENSP00000281474
    PACS1Q6VY072, 3, ENSP000003164544MINT-3372236 I2D: score=1 STRING: ENSP00000316454
    RAB14P611062, 3, ENSP000003629464MINT-3369736 I2D: score=1 STRING: ENSP00000362946
    RABEP1Q152761, 3, ENSP000002624774EBI-447609,EBI-447043 I2D: score=4 STRING: ENSP00000262477
    AP2B1P630103, ENSP000003144144I2D: score=9 STRING: ENSP00000314414
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0015031protein transport ----
    GO:0016032viral process TAS--
    GO:0016192vesicle-mediated transport ----

    Find genes that share ontologies with AP1G1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AP1G1

    5 Novoseek inferred chemical compound relationships for AP1G1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 80.6 4 9668075 (2), 9389793 (1), 10473634 (1)
    propanil 66.4 1 15047686 (1)
    wortmannin 24.6 1 9305867 (1)
    phenylalanine 13.8 1 17506864 (1)
    alanine 7.85 1 9725807 (1)



    Find genes that share compounds with AP1G1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AP1G1 gene (2 alternative transcripts): 
    NM_001030007.1  NM_001128.5  

    Unigene Cluster for AP1G1:

    Adaptor-related protein complex 1, gamma 1 subunit
    Hs.461253  [show with all ESTs]
    Unigene Representative Sequence: NM_001030007
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000299980(uc002faz.3 uc021tky.1 uc021tkz.1 uc010cgg.3 uc002fbb.3)
    ENST00000564155 ENST00000569748(uc010vmh.1) ENST00000570052 ENST00000393512(uc010vmg.1)
    ENST00000565009 ENST00000565642 ENST00000562934 ENST00000568327 ENST00000566179
    ENST00000569044 ENST00000450149 ENST00000563259 ENST00000563104 ENST00000569185
    ENST00000566161 ENST00000567583 ENST00000565412
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AP1G1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AP1G1 (see all 45):
    hsa-miR-548k hsa-miR-29a hsa-miR-371-5p hsa-miR-519a hsa-miR-124 hsa-miR-3150b-3p hsa-miR-3613-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidAP1G1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AP1G1
    Predesigned siRNA for gene silencing in human, mouse, rat AP1G1
    Clone
    Products:
         
    OriGene clones in human, mouse for AP1G1 (see all 12)
    OriGene ORF clones in mouse, rat for AP1G1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AP1G1 (NM_001128)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AP1G1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP1G1
    Addgene plasmids for AP1G1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AP1G1
    OriGene qSTAR qPCR primer pairs in human, mouse for AP1G1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AP1G1
      QuantiTect SYBR Green Assays in human, mouse, rat AP1G1
      QuantiFast Probe-based Assays in human, mouse, rat AP1G1

    Additional mRNA sequence: 

    AB015317.1 AK025020.1 AK128078.1 AK225906.1 AK293233.1 AK294546.1 AK299630.1 AK314484.1 
    AL110198.1 BC003414.1 BC036283.1 BC051747.1 Y12226.1 

    21 DOTS entries:

    DT.101960211  DT.446874  DT.100784009  DT.95122479  DT.91683606  DT.95217459  DT.99999023  DT.100676673 
    DT.100682801  DT.120663855  DT.40115213  DT.75144128  DT.91818456  DT.92052110  DT.95217490  DT.120663803 
    DT.91683941  DT.91787915  DT.95091723  DT.101969870  DT.95217475 

    Selected AceView cDNA sequences (see all 277):

    AK025020 BX362296 BM674992 AA993707 NM_001128 AA789113 AI805479 AI800227 
    AA987620 AA406105 BI964161 CA335955 AK128078 AW956657 BP365891 BM834795 
    AB015317 BE326572 BM822351 BI766972 AI358383 BU902252 AL045231 AI953200 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AP1G1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^
    SP1:                                -                                                                                                                           
    SP2:                                -     -     -     -     -     -     -                                                                                       
    SP3:                                                                                                                                                            
    SP4:                                -     -     -     -     -     -     -                       -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                -           -     -     -     -     -                                                                                       

    ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b
    SP1:                    -                             -                             -                                       
    SP2:                    -                             -                             -                                       
    SP3:                                                                                -                                       
    SP4:  -     -     -     -     -     -     -     -     -     -     -     -           -                                       
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for AP1G1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AP1G1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AP1G1 Expression
    About this image


    AP1G1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    AP1G1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AP1G1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.461253

    UniProtKB/Swiss-Prot: AP1G1_HUMAN, O43747
    Tissue specificity: Widely expressed

        Custom PCR Arrays for AP1G1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AP1G1
    OriGene qSTAR qPCR primer pairs in human, mouse for AP1G1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AP1G1
    QuantiTect SYBR Green Assays in human, mouse, rat AP1G1
    QuantiFast Probe-based Assays in human, mouse, rat AP1G1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1G1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AP1G1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ap1g11 , 5 adaptor protein complex AP-1, gamma 1 subunit1, 5 93.62(n)1
    99.27(a)1
      8 (57.26 cM)5
    117651  NM_009677.51  NP_033807.21 
     1097785545 
    chicken
    (Gallus gallus)
    Aves AP1G11 adaptor-related protein complex 1, gamma 1 subunit 85.22(n)
    97.08(a)
      415880  NM_001006132.1  NP_001006132.1 
    lizard
    (Anolis carolinensis)
    Reptilia AP1G16
    adaptor-related protein complex 1, gamma 1 subunit...
    94(a)
    1 ↔ 1
    GL343483.1(301317-310631)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.64182 Xenopus laevis, Similar to adaptor protein complex more 79.88(n)    BC045070.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc30a112 wufc30a11 78.37(n)   324466  BC047823.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AP-1gamma1 , 3 non-selective vesicle coating3
    AP-1gamma1
    60(a)3
    54.86(n)1
    57.65(a)1
      8C93
    318421  NM_176717.41  NP_788890.21 
    worm
    (Caenorhabditis elegans)
    Secernentea apg-11 apg-1 55.5(n)
    53.05(a)
      173304  NM_170941.6  NP_740937.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APL4(YPR029C)4 Gamma-adaptin, large subunit of the clathrin-associated more   --   16(626967-624469) 856141  NP_015354.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GAMMA-ADAPTIN 11 GAMMA-ADAPTIN 1 54.32(n)
    48.95(a)
      839001  NM_102238.2  NP_173802.1 
    rice
    (Oryza sativa)
    Liliopsida Os.42102 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.03(n)    AK101686.1 


    ENSEMBL Gene Tree for AP1G1 (if available)
    TreeFam Gene Tree for AP1G1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for AP1G1 gene
    AP1G22  AP4E12  
    3 SIMAP similar genes for AP1G1 using alignment to 17 protein entries:     AP1G1_HUMAN (see all proteins):
    AP1G2    AP2A2    AP4E1

    Find genes that share paralogs with AP1G1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AP1G1 (see all 1700)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471655481,2
    --71762420(+) TCCAAC/TTGCAC 2 -- ds50010--------
    rs1893203901,2
    --71762446(+) TGTCTA/GTAACA 2 -- ds50010--------
    rs777921461,2
    C,F--71762455(+) CACAAG/CTTTGT 2 -- ds50012Minor allele frequency- C:0.12NA EA 240
    rs1823698661,2
    --71762474(+) TTGTTC/TTTGAG 2 -- ds50010--------
    rs1391399351,2
    C--71762494(+) CACTC-/TTGTCAC 2 -- ds50010--------
    rs1385528511,2
    --71762521(+) AATGGC/TGTGAT 2 -- ds50010--------
    rs602360551,2
    C--71762703(+) GATCCA/GCCCAC 2 -- ds50010--------
    rs133372241,2
    C,F--71762738(+) tacagG/Ccgtga 2 -- ds50012Minor allele frequency- C:0.50WA 4
    rs1874245631,2
    --71762740(+) CAGGCA/GTGAGC 2 -- ds50010--------
    rs1894686861,2
    --71762780(+) ATTCAA/GATTCC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for AP1G1 (71762903 - 71843104 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for AP1G1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714681CNV Deletion23290073
    esv2668956CNV Deletion23128226
    esv992302CNV Insertion20482838
    esv1254626CNV Insertion17803354
    nsv7285OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AP1G1
    DNA2.0 Custom Variant and Variant Library Synthesis for AP1G1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603533    OMIM disorders: --

    1 disease for AP1G1:    
    About MalaCards
    hypoactive sexual desire disorder

    1 disease from the University of Copenhagen DISEASES database for AP1G1:
    Hypoactive sexual desire disorder

    Find genes that share disorders with AP1G1           About GenesLikeMe

    Genetic Association Database (GAD): AP1G1
    Human Genome Epidemiology (HuGE) Navigator: AP1G1 (1 document)

    Export disorders for AP1G1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AP1G1 gene, integrated from 10 sources (see all 121):
    (articles sorted by number of sources associating them with AP1G1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG). (PubMed id 9653655)1, 2, 3, 9 Peyrard M.... Dumanski J.P. (Genomics 1998)
    2. Identification and characterization of novel clathrin adaptor-related proteins. (PubMed id 9733768)1, 2, 3, 9 Takatsu H.... Nakayama K. (J. Biol. Chem. 1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking. (PubMed id 15775984)1, 2 Neubrand V.E.... Simpson J.C. (EMBO J. 2005)
    5. Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes. (PubMed id 12773381)1, 2 Deneka M.... van der Sluijs P. (EMBO J. 2003)
    6. Structural basis for the accessory protein recruitment by the gamma- adaptin ear domain. (PubMed id 12042876)1, 2 Nogi T.... Wakatsuki S. (Nat. Struct. Biol. 2002)
    7. Definition of the consensus motif recognized by gamma-adaptin ear domains. (PubMed id 14665628)1, 9 Mattera R.... Bonifacino J.S. (J. Biol. Chem. 2004)
    8. The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites. (PubMed id 15143060)1, 9 Mattera R.... Bonifacino J.S. (J. Biol. Chem. 2004)
    9. Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. (PubMed id 12505986)1, 9 Mattera R.... Bonifacino J.S. (EMBO J. 2003)
    10. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 164 HGNC: 555 AceView: AP1G1 Ensembl:ENSG00000166747 euGenes: HUgn164
    ECgene: AP1G1 Kegg: 164 H-InvDB: AP1G1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AP1G1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AP1G1 gene:
    Search GeneIP for patents involving AP1G1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AP1G1   OriGene RNAi products in human, mouse, rat for AP1G1  
     OriGene qPCR primer pairs and template standards for AP1G1   OriGene Protein Over-expression Lysate for AP1G1  
     OriGene MassSpec something-or-other for AP1G1   OriGene clones in human, mouse for AP1G1  
     OriGene qSTAR qPCR primer pairs in human, mouse for AP1G1   OriGene Purified Protein for AP1G1  
     OriGene ORF clones in mouse, rat for AP1G1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AP1G1   OriGene Custom Protein Services for AP1G1  

     
     
     Block miRNA regulation of human, mouse, rat AP1G1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AP1G1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AP1G1 Predesigned siRNA for gene silencing in human, mouse, rat AP1G1
     QuantiFast Probe-based Assays in human, mouse, rat AP1G1 QuantiTect SYBR Green Assays in human, mouse, rat AP1G1
     Custom PCR Arrays for AP1G1 Search Chromatin IP Primers for AP1G1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AP1G1  GeneGlobe Interaction Network for AP1G1
     Regulatory tfbs in AP1G1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for AP1G1 GenScript cDNA clones with any tag delivered in your preferred vector for AP1G1
     GenScript Custom Assay Services for AP1G1 GenScript Custom overexpressing Cell Line Services for AP1G1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for AP1G1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AP1G1 antibodies
     AP1G1 proteins
     AP1G1 lysates
     Antibodies for AP1G1
     See all of Abcam's Antibodies, Kits and Proteins for AP1G1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for AP1G1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1G1
     SwitchGear 3'UTR luciferase reporter plasmids for AP1G1
     SwitchGear Promoter luciferase reporter plasmids for AP1G1
     ThermoFisher Antibodies for AP1G1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP1G1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AP1G1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AP1G1
     LSBio Antibodies in human, mouse, rat for AP1G1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for AP1G1
      Search eBioscience for proteins for AP1G1
      Search eBioscience for elisas for AP1G1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AP1G1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4