Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AP1B1 Gene

protein-coding   GIFtS: 61
GCID: GC22M029723

adaptor-related protein complex 1, beta 1 subunit


(Previous symbols: ADTB1, CLAPB2)
 Explore 9 diseases affiliated with
AP1B1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AP1B1    

Aliases
for AP1B1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Adaptor-Related Protein Complex 1, Beta 1 Subunit1 2     Clathrin Assembly Protein Complex 1 Beta Large Chain2 3
ADTB11 2 3 5     Golgi Adaptor HA1/AP1 Adaptin Beta Subunit2 3
BAM221 2 3 5     AP-1 Complex Subunit Beta-12
CLAPB21 2 3 5     Beta-1-Adaptin1
AP105A1 2     Beta-Prime-Adaptin1
Adapter-Related Protein Complex 1 Subunit Beta-12 3     Beta1-Adaptin1
Adaptor Protein Complex AP-1 Subunit Beta-12 3     Plasma Membrane Adaptor HA2/AP2 Adaptor Beta Subunit2
Beta-Adaptin 12 3     Beta-1-Adaptin1

External Ids:    HGNC: 5541   Entrez Gene: 1622   Ensembl: ENSG000001002807   OMIM: 6001575   UniProtKB: Q105673   

Export aliases for AP1B1 gene to outside databases

Previous GC identifers: GC22M026419 GC22M028048 GC22M012687


Summaries
for AP1B1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AP1B1:
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it
mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic
tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small
adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member
of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: AP1B1_HUMAN, Q10567
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the
late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to
membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

Gene Wiki entry for AP1B1


Genomic Views
for AP1B1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AP1B1 gene promoter:
         Sox5   AML1a   SREBP-1c   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   STAT5A   POU3F2   SREBP-1b   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AP1B1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AP1B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP1B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

AP1B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP1B1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M029723:  view genomic region     (about GC identifiers)

Start:
 29,723,669 bp from pter      End:
 29,819,168 bp from pter
Size:
 95,500 bases      Orientation:
 minus strand

Proteins
for AP1B1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AP1B1_HUMAN, Q10567 (See protein sequence)
Recommended Name: AP-1 complex subunit beta-1  
Size: 949 amino acids; 104637 Da
Subunit: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1
and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type
subunit AP1S1 or AP1S2 or AP1S3)
Subcellular location: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane
protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at
the Golgi complex
Secondary accessions: C9JRD1 F8WDL0 P78436 Q20WL3 Q86X54
Alternative splicing: 4 isoforms:  Q10567-1   Q10567-2   Q10567-3   Q10567-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AP1B1: NX_Q10567

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q10567

    • AP1B1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001118.3  NP_001159491.1  NP_663782.2  

    ENSEMBL proteins: 
     ENSP00000384194   ENSP00000319361   ENSP00000386071   ENSP00000400022   ENSP00000392735  
     ENSP00000387612   ENSP00000350199   ENSP00000348297   ENSP00000400065  
    Reactome Protein details: Q10567
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: AP1B1
    OriGene Custom Protein Services for AP1B1 
    GenScript Custom Purified and Recombinant Proteins Services for AP1B1
    Novus Biologicals AP1B1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005765lysosomal membrane TAS--
    GO:0005829cytosol TAS--
    GO:0030117membrane coat ----
    GO:0030131clathrin adaptor complex IEA--


    AP1B1 for ontologies           About GeneDecksing



    AP1B1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: AP1B1
    OriGene Custom Antibody Services for AP1B1 
    GenScript Custom Superior Antibodies Services for AP1B1
    Novus Biologicals AP1B1 Antibody
    Search for Antibodies for AP1B1 at Abcam  
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for AP1B1

    Assay Products for AP1B1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AP1B1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for AP1B1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AP1B1 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR008152 Clathrin_a/b/g-adaptin_app_Ig
     IPR011989 ARM-like
     IPR002553 Clathrin/coatomer_adapt-like_N
     IPR013037 Clathrin_b-adaptin_app_Ig-like
     IPR015151 B-adaptin_app_sub_C

    Graphical View of Domain Structure for InterPro Entry Q10567

    ProtoNet protein and cluster: Q10567

    4 Blocks protein families:
    IPB000225 Armadillo repeat
    IPB002553 Adaptin
    IPB003016 2-oxo acid dehydrogenase
    IPB008152 Alpha/gamma adaptin


    UniProtKB/Swiss-Prot: AP1B1_HUMAN, Q10567
    Similarity: Belongs to the adaptor complexes large subunit family


    Function
    for AP1B1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AP1B1_HUMAN, Q10567
    Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the
    late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to
    membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): AP1B1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AP1B1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate AP1B1 (see all 15):
    hsa-miR-30c hsa-miR-34b* hsa-miR-30d hsa-miR-133b hsa-miR-3647-3p hsa-miR-30a hsa-miR-656 hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmid: AP1B1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AP1B1 (see all 7)
    OriGene shRNA RFP: AP1B1
    OriGene siRNA: AP1B1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AP1B1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for AP1B1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP1B1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP1B1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): AP1B1 (NM_001127)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AP1B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP1B1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for AP1B1
    Search LifeMap BioReagents cell lines for AP1B1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1B1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS7987321
    GO:0005515protein binding IPI9733768
    GO:0008565protein transporter activity IEA--


    AP1B1 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Ap1b1 (no phenotypes)

    AP1B1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AP1B1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin derived vesicle budding
    		Clathrin derived vesicle budding1.00
    		Golgi Associated Vesicle Biogenesis0.89
    		trans-Golgi Network Vesicle Budding1.00
    		Lysosome Vesicle Biogenesis0.39
    2Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
    		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters1.00
    		Nef mediated downregulation of MHC class I complex cell surface expression0.48
    		The role of Nef in HIV-1 replication and disease pathogenesis0.75
    		Degradation of MHC I Complex0.48
    3Clathrin-dependent protein traffic
    		Clathrin-dependent protein traffic1.00
    		Transport_Clathrin-coated vesicle cycle0.66
    4Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    5HIV Infection
    		HIV Infection1.00
    		Host Interactions of HIV factors0.64

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for AP1B1
        Clathrin-dependent protein traffic

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AP1B1
        CTLA4 Signaling

    1 GeneGo (Thomson Reuters) Pathway for AP1B1
        Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for AP1B1 
        FOXA1 transcription factor network

    5/15        Reactome Pathways for AP1B1 (see all 15)
        Membrane Trafficking
    Clathrin derived vesicle budding
    trans-Golgi Network Vesicle Budding
    Adaptive Immune System
    Lysosome Vesicle Biogenesis


    1         Kegg Pathway  (Kegg details for AP1B1):
        Lysosome


    AP1B1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AP1B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/834 Interacting proteins for AP1B1 (Q105672, 3 ENSP000003501994) via UniProtKB, MINT, STRING, and/or I2D (see all 834)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BUB1O436832, 3, ENSP000003025304MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000302530
    PRKDCP785272, 3, ENSP000003134204MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000313420
    ARF5P840852, 3, ENSP000000002334MINT-7945693 I2D: score=2 STRING: ENSP00000000233
    BUB1BO605662, 3, ENSP000002875984MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000287598
    DNM2P505702, ENSP000003527214MINT-7945693 MINT-7947479 STRING: ENSP00000352721
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0006897endocytosis IEA--
    GO:0016032viral reproduction TAS--
    GO:0016044cellular membrane organization TAS--


    AP1B1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AP1B1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for AP1B1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AP1B1
    Search CenterWatch for drugs/clinical trials and news about AP1B1 

    Transcripts
    for AP1B1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AP1B1 gene (3 alternative transcripts): 
    NM_001127.3  NM_001166019.1  NM_145730.2  

    Unigene Cluster for AP1B1:

    Adaptor-related protein complex 1, beta 1 subunit
    Hs.368794  [show with all ESTs]
    Unigene Representative Sequence: NM_001127
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482818(uc003afh.3) ENST00000405198 ENST00000317368 ENST00000402502
    ENST00000472057 ENST00000421126 ENST00000415756 ENST00000473606 ENST00000415447
    ENST00000357586(uc011ako.2 uc003afj.3) ENST00000356015 ENST00000432560(uc003afl.3 uc003afi.3)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): AP1B1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AP1B1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate AP1B1 (see all 15):
    hsa-miR-30c hsa-miR-34b* hsa-miR-30d hsa-miR-133b hsa-miR-3647-3p hsa-miR-30a hsa-miR-656 hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmid: AP1B1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AP1B1 (see all 7)
    OriGene shRNA RFP: AP1B1
    OriGene siRNA: AP1B1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AP1B1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP1B1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP1B1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): AP1B1 (NM_001127)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AP1B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP1B1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP1B1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AP1B1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP1B1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP1B1

    Additional cDNA sequence: 

    AK294406.1 AK296567.1 AK299613.1 BC046242.1 BX537680.1 CT841508.1 L13939.1 

    11 DOTS entries:

    DT.100784203  DT.100694559  DT.100784204  DT.111326  DT.95253591  DT.100724412  DT.99994320  DT.101956364 
    DT.120663178  DT.95274485  DT.120663191 

    24/91 AceView cDNA sequences (see all 91):

    BM783046 BX385029 NM_001127 BE253600 BX385028 AI084003 BM909530 BM661552 
    BE856022 BU158849 AW162402 H55678 BC046242 CK429947 AI922129 CR626722 
    BF808247 CD244097 AA367943 NM_145730 BF808243 BX325392 BM677732 BI018253 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AP1B1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b · 19c ^
    SP1:              -                       -                                                                             -           -           -               
    SP2:                                      -                                                                                                                     
    SP3:                                                                                                                                -                           
    SP4:              -                                                                                                                                             
    SP5:                                                                                                                                            -               

    ExUns: 20 ^ 21 ^ 22a · 22b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for AP1B1

    Expression
    for AP1B1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AP1B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCAAGACCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See AP1B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AP1B1

    SOURCE GeneReport for Unigene cluster: Hs.368794

    UniProtKB/Swiss-Prot: AP1B1_HUMAN, Q10567
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for AP1B1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP1B1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AP1B1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP1B1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP1B1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1B1

    Orthologs
    for AP1B1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AP1B1 gene from 7/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves AP1B11 adaptor-related protein complex 1, beta 1 subunit 86.64(n)
    95.25(a)    		   417021  XM_415311.3  XP_415311.3 
    lizard
    (Anolis carolinensis)    		 Reptilia AP1B16
    		 --
    		 94(a)
    		 1 ↔ 1
    		 GL343417.1(73808-81934)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa16e072 wufa16e07 77.05(n)   334632  BC049138.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Bap1 , 3 non-selective vesicle coating3
    Beta Adaptin1    		 72(a)3
    73.03(n)1
    76.88(a)1    		   329871  NM_078691.21  NP_523415.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea apb-11 Protein APB-1 61.6(n)
    66.92(a)    		   175376  NM_001027766.2  NP_001022937.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G234601 beta-adaptin-like protein C 59.47(n)
    63.28(a)    		   828445  NM_118475.3  NP_194077.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g03556001 hypothetical protein 58.87(n)
    61.3(a)    		   4332864  NM_001056670.1  NP_001050135.1 


    ENSEMBL Gene Tree for AP1B1 (if available)
    TreeFam Gene Tree for AP1B1 (if available) 

    Paralogs
    for AP1B1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AP1B1 gene
    AP2B12  AP4B12  
    4 SIMAP similar genes for AP1B1 using alignment to 3 protein entries:     AP1B1_HUMAN (see all proteins):
    AP2B1    DKFZp781K0743    AP4B1    AP3B1

    AP1B1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AP1B1
    PGOHUM00000246567


    Genomic Variants
    for AP1B1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1062 NCBI SNPs in AP1B1 are shown (see all 1062)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1875413961,2
    		--29723343(+) CAGGGG/TATCTC 3 -- ds50010--------
    rs1469026091,2
    		--29723557(+) TGCCAC/TGGGAG 3 -- ds50010--------
    rs1932732121,2
    		--29723585(+) ACCACC/TGGAGC 3 -- ds50010--------
    rs757098481,2
    		F,--29723641(+) GCCTCG/AGGCCT 3 -- ds50012Minor allele frequency- A:0.07WA NA 238
    rs1479432441,2
    		--29723819(+) CATTCA/GGTGGA 3 -- ut310--------
    rs776977681,2
    		C,F,--29724002(+) TTACCC/TAGCCC 3 -- ut311Minor allele frequency- T:0.02WA 118
    rs1850235951,2
    		--29724016(+) CTCTCA/GGCCCA 3 -- ut310--------
    rs1901680141,2
    		--29724082(+) CAGTGA/GCCACC 3 -- ut310--------
    rs1163289121,2
    		C,F,--29724187(+) ATGTGG/AGTCAG 3 -- ut311Minor allele frequency- A:0.08WA 118
    rs1417320101,2
    		--29724189(+) GTGGGC/TCAGCA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for AP1B1 (29723669 - 29819168 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for AP1B1
         3 CNVs: 67865 103149 53501

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AP1B1
    DNA2.0 Custom Variant and Variant Library Synthesis for AP1B1

    Disorders / Diseases
    for AP1B1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AP1B1 for disorders           About GeneDecksing

    OMIM gene information: 600157    OMIM disorders: --

    9 diseases for AP1B1:    About MalaCards
    meningioma    kaposi's sarcoma    hepatitis c    neurofibromatosis
    sarcoma    hepatitis    immunodeficiency    malaria
    prostatitis

    2 Novoseek disease relationships for AP1B1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    meningioma 63.7 6 7987321 (3), 9271666 (1), 8812422 (1)
    tumors 0 3 7987321 (2), 9271666 (1)

    Genetic Association Database (GAD): AP1B1
    Human Genome Epidemiology (HuGE) Navigator: AP1B1 (1 document)

    Export disorders for AP1B1 gene to outside databases

    Publications
    for AP1B1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AP1B1 gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with AP1B1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12. (PubMed id 8812422)1, 2, 3, 9 Peyrard M.... Dumanski J.P. (1996)
    2. Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene. (PubMed id 7987321)1, 2, 3, 9 Peyrard M.... Dumanski J.P. (1994)
    3. Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)1, 4 Saito T....Kawata S. (2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    5. A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. (PubMed id 11106728)1, 9 Nakagawa T....Hirokawa N. (2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (2012)
    10. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)

    External Searches for AP1B1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AP1B1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 162 HGNC: 554 AceView: AP1B1 Ensembl:ENSG00000100280 euGenes: HUgn162
    ECgene: AP1B1 Kegg: 162 H-InvDB: AP1B1

    Other Databases showing AP1B1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AP1B1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AP1B1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AP1B1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for AP1B1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AP1B1 gene:
    Search GeneIP for patents involving AP1B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for AP1B1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore small molecules (inhibitor) for AP1B1
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for AP1B1   OriGene shRNA RFP for AP1B1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AP1B1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP1B1  
     OriGene Protein Over-expression Lysate for AP1B1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for AP1B1   OriGene 3'-UTR Clone for AP1B1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP1B1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP1B1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AP1B1   OriGene Custom Protein Services for AP1B1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AP1B1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AP1B1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP1B1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AP1B1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP1B1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP1B1
     GenScript Custom Purified and Recombinant Proteins Services for AP1B1 GenScript cDNA clones with any tag delivered in your preferred vector for AP1B1
     GenScript Custom Assay Services for AP1B1 GenScript Custom Superior Antibodies Services for AP1B1
     GenScript Custom overexpressing Cell Line Services for AP1B1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in AP1B1 promoter
     Search Chromatin IP Primers for AP1B1
     RT2 qPCR Primer Assay in human, mouse, rat AP1B1
     Search GNC Networks for AP1B1
     SABiosciences PCR Arrays including human, mouse, rat AP1B1
     Search Tocris compounds for AP1B1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AP1B1 antibodies
     AP1B1 proteins
     Search for Antibodies for AP1B1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for AP1B1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for AP1B1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1B1
     SwitchGear 3'UTR luciferase reporter plasmids for AP1B1
     SwitchGear Promoter luciferase reporter plasmids for AP1B1
     ThermoFisher Antibodies for AP1B1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP1B1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      AP1B1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4