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AP1AR Gene

protein-coding   GIFtS: 50
GCID: GC04P113153

Adaptor-Related Protein Complex 1 Associated Regulatory...

(Previous name: chromosome 4 open reading frame 16)
(Previous symbol: C4orf16)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adaptor-Related Protein Complex 1 Associated Regulatory Protein1 2     Gamma1-Adaptin Brefeldin A Resistance1
C4orf161 2 3 5     AP-1 Complex-Associated Regulatory Protein2
GBAR2 3 5     gadkin2
Adapter-Related Protein Complex 1-Associated Regulatory Protein2 3     gamma-BAR2
Gamma-1-Adaptin Brefeldin A Resistance Protein2 3     Gamma1-Adaptin Brefeldin A Resistance Protein, Gamma-BAR2
Gamma-A1-Adaptin And Kinesin Interactor2 3     2c183
2C182 5     Gadkin3
Chromosome 4 Open Reading Frame 161     Gamma-BAR3

External Ids:    HGNC: 288081   Entrez Gene: 554352   Ensembl: ENSG000001386607   OMIM: 6108515   UniProtKB: Q63HQ03   

Export aliases for AP1AR gene to outside databases

Previous GC identifers: GC04P113373 GC04P108884


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AP1AR Gene:
AP1AR (adaptor-related protein complex 1 associated regulatory protein) is a protein-coding gene. Diseases associated with AP1AR include alcohol dependence.

UniProtKB/Swiss-Prot: AP1AR_HUMAN, Q63HQ0
Function: Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and
endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adapter
complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from
membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based
plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in
calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading,
size and motility via intracellular sequestration of the Arp2/3 complex

Gene Wiki entry for AP1AR (C4orf16) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AP1AR
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAP1AR promoter sequence
   Search Chromatin IP Primers for AP1AR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AP1AR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

AP1AR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP1AR gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P113153:  view genomic region     (about GC identifiers)

Start:
113,152,893 bp from pter      End:
113,191,211 bp from pter
Size:
38,319 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AP1AR_HUMAN, Q63HQ0 (See protein sequence)
Recommended Name: AP-1 complex-associated regulatory protein  
Size: 302 amino acids; 34280 Da
Subunit: Interacts (via coiled-coil domain) with AP1G1 (via GAE domain). Interacts with KIF5B. Associates with the
Arp2/3 complex
Sequence caution: Sequence=AAF71037.1; Type=Erroneous initiation;
Secondary accessions: B2RCV7 Q96GG6 Q9H0V0 Q9P1L4
Alternative splicing: 2 isoforms:  Q63HQ0-1   Q63HQ0-2   

Explore the universe of human proteins at neXtProt for AP1AR: NX_Q63HQ0

Explore proteomics data for AP1AR at MOPED

Post-translational modifications: 

  • Palmitoylated1
  • Ubiquitination2 at Lys30
  • Modification sites at PhosphoSitePlus

  • See AP1AR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121898.1  NP_061039.3  

    ENSEMBL proteins: 
     ENSP00000274000   ENSP00000309023   ENSP00000422529  

    AP1AR Human Recombinant Protein Products:

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    Novus Biologicals AP1AR Protein
    Novus Biologicals AP1AR Lysate
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    ProSpec Recombinant Protein for AP1AR
    Cloud-Clone Corp. Proteins for AP1AR

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    Cloud-Clone Corp. CLIAs for AP1AR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q63HQ0


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP1AR_HUMAN, Q63HQ0
    Function: Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and
    endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adapter
    complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from
    membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based
    plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in
    calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading,
    size and motility via intracellular sequestration of the Arp2/3 complex

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019894kinesin binding IDA19706427
    GO:0035650AP-1 adaptor complex binding IDA19706427
         
    AP1AR for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ap1ar):
     no phenotypic analysis 

    AP1AR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ap1artm1.1Vha for AP1AR

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AP1AR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AP1AR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AP1AR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AP1AR

    miRNA
    Products:
        
    miRTarBase miRNAs that target AP1AR:
    hsa-mir-93-5p (MIRT048859)

    Block miRNA regulation of human, mouse, rat AP1AR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AP1AR (see all 32):
    hsa-miR-25 hsa-miR-488 hsa-miR-4325 hsa-miR-133a hsa-miR-3613-3p hsa-miR-92b hsa-miR-616 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidAP1AR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AP1AR

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1AR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AP1AR_HUMAN, Q63HQ0: Golgi apparatus, trans-Golgi network. Late endosome. Early endosome. Note=Localizes to the
    juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle
    between the juxta-nuclear area and the cell periphery
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    golgi apparatus4
    nucleus4
    cytosol3
    mitochondrion2
    chloroplast1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome ----
    GO:0005769early endosome IEA--
    GO:0005770late endosome IEA--

    AP1AR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AP1AR
    Interactions:

        Search GeneGlobe Interaction Network for AP1AR

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for AP1AR (Q63HQ03 ENSP000002740004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GGA1Q9UJY53, ENSP000003413444I2D: score=2 STRING: ENSP00000341344
    AP1G1O437473, ENSP000003771484I2D: score=1 STRING: ENSP00000377148
    RB1P064003I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    --Q8IY973I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001920negative regulation of receptor recycling IMP19706427
    GO:0015031protein transport IEA--
    GO:0034315regulation of Arp2/3 complex-mediated actin nucleation IEA--
    GO:0034613cellular protein localization IEA--
    GO:0048203vesicle targeting, trans-Golgi to endosome IDA19706427

    AP1AR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AP1AR



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AP1AR gene (2 alternative transcripts): 
    NM_001128426.1  NM_018569.4  

    Unigene Cluster for AP1AR:

    Adaptor-related protein complex 1 associated regulatory protein
    Hs.435991  [show with all ESTs]
    Unigene Representative Sequence: NM_018569
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274000(uc003iaj.4 uc003iak.4) ENST00000510527(uc010imm.1)
    ENST00000502954 ENST00000309703 ENST00000506522 ENST00000512741
    miRNA
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    Block miRNA regulation of human, mouse, rat AP1AR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AP1AR (see all 32):
    hsa-miR-25 hsa-miR-488 hsa-miR-4325 hsa-miR-133a hsa-miR-3613-3p hsa-miR-92b hsa-miR-616 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidAP1AR 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AP1AR
      QuantiTect SYBR Green Assays in human, mouse, rat AP1AR
      QuantiFast Probe-based Assays in human, mouse, rat AP1AR

    Additional mRNA sequence: 

    AF116612.1 AK310787.1 AK315299.1 AL136628.1 BC009485.2 BX647702.1 

    4 DOTS entries:

    DT.211868  DT.100778810  DT.95163297  DT.121240087 

    Selected AceView cDNA sequences (see all 64):

    AA256226 AL514472 BE894199 AI065133 BE503347 BM468321 AW963236 AI686453 
    AI859013 CB851616 BM823928 AA345339 BF115177 AI394199 BG110425 CB131910 
    AI632191 AA127683 AI570945 AI285298 BM974015 AW674667 AF116612 AI492921 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AP1AR    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                -           -                                             
    SP2:                                -           -                 -                           
    SP3:                                -                                                         
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for AP1AR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AP1AR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCCCTTTC
    AP1AR Expression
    About this image

    AP1AR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AP1AR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435991
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP1AR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AP1AR gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ap1ar1 , 5 adaptor-related protein complex 1 associated regulatory more1, 5 84(n)1
    91.28(a)1
      3 (56.54 cM)5
    2115561  NM_145964.21  NP_666076.21 
     1278072645 
    chicken
    (Gallus gallus)
    Aves AP1AR1 adaptor-related protein complex 1 associated regulatory more 81.99(n)
    84.56(a)
      422693  XM_420646.4  XP_420646.2 
    lizard
    (Anolis carolinensis)
    Reptilia AP1AR6
    adaptor-related protein complex 1 associated regul...
    79(a)
    1 ↔ 1
    5(143164385-143185491)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.113772 Xenopus laevis transcribed sequences 80.17(n)    BX844011.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003322651 AP-1 complex-associated regulatory protein-like 61.17(n)
    58.76(a)
      100332265  XM_002664306.3  XP_002664352.1 


    ENSEMBL Gene Tree for AP1AR (if available)
    TreeFam Gene Tree for AP1AR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AP1AR (see all 689)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378763121,2
    --113150943(+) TTTTTA/GAGCAT 2 -- us2k10--------
    rs1494492911,2
    --113150990(+) TTCTCA/GGAATG 2 -- us2k10--------
    rs1830006551,2
    --113151122(+) ATGCAC/TTTTAA 2 -- us2k10--------
    rs119331821,2
    H--113151175(+) ATTTGA/TATTGC 2 -- us2k10--------
    rs1879691931,2
    --113151261(+) TTTAAC/TAACGG 2 -- us2k10--------
    rs1929936851,2
    --113151682(+) TTCCAA/TAGGAT 2 -- us2k10--------
    rs76994351,2
    C,F,A,H--113151732(+) AATGAC/TTATTT 2 -- us2k1 tfbs322Minor allele frequency- T:0.29NS EA NA WA CSA 2344
    rs777079671,2
    C,F--113151739(+) ATTTCA/GTTAAT 2 -- us2k12Minor allele frequency- G:0.11WA EA 238
    rs1823936071,2
    --113152133(+) TGTCTA/TGAGGC 2 -- us2k10--------
    rs1878834011,2
    --113152178(+) AGGGCC/TGCGGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for AP1AR (113152893 - 113191211 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AP1AR: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AP1AR
    DNA2.0 Custom Variant and Variant Library Synthesis for AP1AR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610851    OMIM disorders: --

    1 disease for AP1AR:    About MalaCards
    alcohol dependence


    AP1AR for disorders           About GeneDecksing

    Genetic Association Database (GAD): AP1AR
    Human Genome Epidemiology (HuGE) Navigator: AP1AR (1 document)

    Export disorders for AP1AR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AP1AR gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with AP1AR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking. (PubMed id 15775984)1, 2, 3 Neubrand V.E.... Simpson J.C. (EMBO J. 2005)
    2. Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes. (PubMed id 21525240)1, 2 Laulagnier K....Gruenberg J. (Mol. Biol. Cell 2011)
    3. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    4. A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR. (PubMed id 19965873)1, 2 Maritzen T....Haucke V. (J. Biol. Chem. 2010)
    5. Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex. (PubMed id 19706427)1, 2 Schmidt M.R....Haucke V. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    10. Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. (PubMed id 22689987)2 Maritzen T....Haucke V. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55435 HGNC: 28808 AceView: C4orf16 Ensembl:ENSG00000138660 euGenes: HUgn55435
    ECgene: AP1AR H-InvDB: AP1AR

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AP1AR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AP1AR gene:
    Search GeneIP for patents involving AP1AR

    GeneCards and IP:
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