Aliases for AOX1 Gene
External Ids for AOX1 Gene
Previous GeneCards Identifiers for AOX1 Gene
Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for AOX1 Gene
AOX1 (Aldehyde Oxidase 1) is a Protein Coding gene. Diseases associated with AOX1 include xanthinuria and xanthinuria type 2. Among its related pathways are Metabolism and Valine, leucine and isoleucine degradation. GO annotations related to this gene include oxidoreductase activity and electron carrier activity. An important paralog of this gene is XDH.
UniProtKB/Swiss-Prot for AOX1 Gene
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.