AOC3 Gene

Aliases
for AOC3 gene

Previous GC identifers: GC17M040621 GC17P043165 GC17P040911 GC17P041376 GC17P038256 GC17P036767

Summaries
for AOC3 gene

Genomic Views
for AOC3 gene

RefSeq DNA sequence:

NC_000017.10  NC_018928.1  NT_010783.15  

SwitchGear Promoter luciferase reporter plasmid: AOC3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AOC3

AOC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P041003:  view genomic region     (about GC identifiers)

Proteins
for AOC3 gene

6/7 PDB 3D structures from and Proteopedia for AOC3 (see all 7):

1PU4 (3D)        1US1 (3D)        2C10 (3D)        2C11 (3D)        2Y73 (3D)        2Y74 (3D)    

Explore the universe of human proteins at neXtProt for AOC3: NX_Q16853

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for AOC3 (VAP-1/AOC3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: AOC3 OriGene Custom Protein Services for AOC3
	GenScript Custom Purified and Recombinant Proteins Services for AOC3
	Novus Biologicals AOC3 Proteins Novus Biologicals AOC3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for AOC3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for AOC3 (VAP-1/AOC3)
	OriGene Antibodies: AOC3 OriGene Custom Antibody Services for AOC3
	GenScript Custom Superior Antibodies Services for AOC3
	Novus Biologicals AOC3 Antibodies
	Abcam antibodies for AOC3
	Uscn Antibodies for AOC3
	ThermoFisher Antibodies for AOC3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for AOC3 (VAP-1/AOC3)         (see all)
	GenScript Custom Assay Services for AOC3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for AOC3

Protein Domains /
Families
for AOC3 gene

ProtoNet protein and cluster: Q16853

Function
for AOC3 gene

miRNA Products:		OriGene 3'-UTR Clone: AOC3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AOC3
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate AOC3:
		hsa-miR-3150b-3p hsa-miR-558 hsa-miR-1291
		SwitchGear 3'UTR luciferase reporter plasmid: AOC3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AOC3 (see all 7) OriGene shRNA RFP: AOC3 OriGene siRNA: AOC3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AOC3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for AOC3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AOC3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AOC3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: AOC3 (NM_003734)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AOC3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AOC3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for AOC3
		Search LifeMap BioReagents cell lines for AOC3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AOC3

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

(inferred from 1 allele) (MGI details for Aoc3)

Pathways & Interactions
for AOC3 gene

	Super-pathway	contained gene-specific pathways
1	Tyrosine metabolism	Tyrosine metabolism 1.00 Tyrosine metabolism p.1 (dopamine) 0.28 Phenylalanine metabolism 0.35 Tyrosine metabolism p.1 (dopamine) 0.28
2	phenylethylamine degradation I	phenylethylamine degradation I 1.00
3	beta-Alanine metabolism	beta-Alanine metabolism 1.00
4	Glycine, serine and threonine metabolism	Glycine, serine and threonine metabolism 1.00
5	Metabolism	Metabolic pathways 0.38

1 EMD Millipore Pathway for AOC3

Tyrosine metabolism p.1 (dopamine)

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AOC3

Transendothelial Migration of Leukocytes

1 GeneGo (Thomson Reuters) Pathway for AOC3

Tyrosine metabolism p.1 (dopamine)

2 BioSystems Pathways for AOC3

	spermine and spermidine degradation I
	phenylethylamine degradation I

5         Kegg Pathways  (Kegg details for AOC3)

	Glycine, serine and threonine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	beta-Alanine metabolism
	Metabolic pathways

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for AOC3 gene

Transcripts
for AOC3 gene

Expression
for AOC3 gene

AOC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACTGTATT

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LiverSinusoidsSinusoidal Endothelial Cells			Endothelium
	HeartAtrioventricular NodeAtrioventricular Node Cells			Myocardium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	White adipocyte-like cells (Differentiation of ...)			Adipose

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AOC3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AOC3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AOC3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AOC3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AOC3

Orthologs
for AOC3 gene

Paralogs
for AOC3 gene

Paralogs for AOC3 gene

AOC2²  ABP1²  

2 SIMAP similar genes for AOC3 using alignment to 6 protein entries:     AOC3_HUMAN (see all proteins):

AOC2    ABP1

AOC3 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for AOC3
PGOHUM00000237400

Genomic Variants
for AOC3 gene

10/203 NCBI SNPs in AOC3 are shown (see all 203)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1482750431,2		--	41003267(+)	CCCCCC/TACCCC	1	--	ut51		0	--	--	--	--
rs339681761,2	C,F,	--	41003337(+)	TTGAAT/GCAGCT	1	--	ut51		12		NS NA	380
rs1997485171,2		--	41003353(+)	TCTTCA/GTGGGA	1	--	ut51		0	--	--	--	--
rs339542111,2	C,F	--	41003374(+)	GAAGAA/C/GAATCC	3	K T R	mis1		13		NS NA EU	1695
rs1387253491,2	C,F,	--	41003381(+)	ATCCTC/TGTGCT	2	L	syn1		1		NA	4552
rs1507966671,2	C,	--	41003400(+)	TGGCCA/GTCATC	2	I V	mis1		0	--	--	--	--
rs2018476501,2		--	41003479(+)	TCCCCA/GTTGCC	2	H R	mis1		0	--	--	--	--
rs1894106191,2		--	41003522(+)	CACCCC/TGGCCA	2	P	syn1		0	--	--	--	--
rs2010461181,2		--	41003565(+)	AGCTGA/GCGGCT	2	T A	mis1		0	--	--	--	--
rs4026801,2	C,	--	41003593(-)	CCAGCC/TGCTGG	2	Q R	mis1 ese3		4		NA MN	4634

HapMap Linkage Disequilibrium report for AOC3 (41003201 - 41010147 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AOC3
     1 CNV: 0206

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AOC3

DNA2.0 Custom Variant and Variant Library Synthesis for AOC3

Disorders / Diseases
for AOC3 gene

20/58 diseases for AOC3

10/43 Novoseek disease relationships for AOC3 gene (see all 43)    About this table

Publications
for AOC3 gene

PubMed articles for AOC3 gene, integrated from 9 sources (see all 317): (articles sorted by number of sources associating them with AOC3)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule. (PubMed id 9653080)^{1, 2, 3} Smith D.J.... Jalkanen S. (1998)
2. Cloning and sequencing of a copper-containing, topaquinone-containing monoamine oxidase from human placenta. (PubMed id 8972912)^{1, 2, 3} Zhang X. and McIntire W.S. (1996)
3. Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes. (PubMed id 17400359)^{1, 2, 9} Bour S.... Carpene C. (2007)
4. Characterization of AOC2 gene encoding a copper-binding amine oxidase expressed specifically in retina. (PubMed id 14585497)^{1, 2, 9} Zhang Q.... Iwata T. (2003)
5. Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications. (PubMed id 16046623)^{1, 2} Airenne T.T.... Salminen T.A. (2005)
6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
7. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)^{1, 2} Aboulaich N.... Vener A.V. (2004)
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
9. Localization of vascular adhesion protein-1 (VAP-1) i n the human eye. (PubMed id 19761765)^{1, 9} Almulki L....Hafezi-Moghadam A. (2010)
10. Developmental regulation of the adhesive and enzymatic activity of vascular adhesion protein-1 (VAP-1) in humans. (PubMed id 16556889)^{1, 9} Salmi M. and Jalkanen S. (2006)

External Searches for AOC3 gene

Genome Databases showing AOC3 gene

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Products
for AOC3 gene