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Aliases for AOC3 Gene

Aliases for AOC3 Gene

  • Amine Oxidase, Copper Containing 3 2 3
  • Semicarbazide-Sensitive Amine Oxidase 3 4
  • Vascular Adhesion Protein 1 2 4
  • Copper Amine Oxidase 3 4
  • EC 1.4.3.21 4 63
  • VAP-1 3 4
  • HPAO 3 4
  • SSAO 3 4
  • VAP1 3 4
  • Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) 3
  • Placenta Copper Monamine Oxidase 3
  • EC 1.4.3 63

External Ids for AOC3 Gene

Previous GeneCards Identifiers for AOC3 Gene

  • GC17M040621
  • GC17P043165
  • GC17P040911
  • GC17P041376
  • GC17P038256
  • GC17P041003
  • GC17P036767

Summaries for AOC3 Gene

Entrez Gene Summary for AOC3 Gene

  • This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

GeneCards Summary for AOC3 Gene

AOC3 (Amine Oxidase, Copper Containing 3) is a Protein Coding gene. Diseases associated with AOC3 include perinephritis and microvascular complications of diabetes 5. Among its related pathways are Integrin Pathway and Metabolism. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is AOC2.

UniProtKB/Swiss-Prot for AOC3 Gene

  • Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.

Gene Wiki entry for AOC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AOC3 Gene

Genomics for AOC3 Gene

Regulatory Elements for AOC3 Gene

Genomic Location for AOC3 Gene

Chromosome:
17
Start:
42,851,123 bp from pter
End:
42,858,130 bp from pter
Size:
7,008 bases
Orientation:
Plus strand

Genomic View for AOC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AOC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AOC3 Gene

Proteins for AOC3 Gene

  • Protein details for AOC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16853-AOC3_HUMAN
    Recommended name:
    Membrane primary amine oxidase
    Protein Accession:
    Q16853
    Secondary Accessions:
    • B2RCI5
    • K7ESB3
    • L0L8N9
    • Q45F94

    Protein attributes for AOC3 Gene

    Size:
    763 amino acids
    Molecular mass:
    84622 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit.;
    Cofactor:
    Name=Cu cation; Xref=ChEBI:CHEBI:23378; Note=Binds 1 copper ion per subunit.;
    Cofactor:
    Name=L-topaquinone; Xref=ChEBI:CHEBI:79027; Note=Contains 1 topaquinone per subunit.;
    Quaternary structure:
    • Homodimer; disulfide-linked. Can heterodimerize with isoform 2 leading to reduced surface expression. Forms a heterodimer with AOC2.

    Three dimensional structures from OCA and Proteopedia for AOC3 Gene

    Alternative splice isoforms for AOC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AOC3 Gene

Proteomics data for AOC3 Gene at MOPED

Post-translational modifications for AOC3 Gene

  • N- and O-glycosylated.
  • Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue
  • Glycosylation at Asn 137, Thr 212, Asn 232, Asn 294, Asn 592, Asn 618, and Asn 666
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for AOC3 Gene

Suggested Antigen Peptide Sequences for AOC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16853

UniProtKB/Swiss-Prot:

AOC3_HUMAN :
  • Belongs to the copper/topaquinone oxidase family.
Family:
  • Belongs to the copper/topaquinone oxidase family.
genes like me logo Genes that share domains with AOC3: view

No data available for Gene Families for AOC3 Gene

Function for AOC3 Gene

Molecular function for AOC3 Gene

GENATLAS Biochemistry:
amine oxidase,copper containing 3,endothelial sialoglycoprotein induced under inflammatory conditions,mediating tissue selective lymphocyte binding
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.94 mM for 2-phenylethylamine {ECO:0000269 PubMed:19588076}; KM=0.67 mM for methylamine {ECO:0000269 PubMed:19588076};
UniProtKB/Swiss-Prot CatalyticActivity:
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
UniProtKB/Swiss-Prot Function:
Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated during in vitro adipocyte differentiation.

Enzyme Numbers (IUBMB) for AOC3 Gene

Gene Ontology (GO) - Molecular Function for AOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IDA 19764817
GO:0005507 copper ion binding IDA 19764817
GO:0005509 calcium ion binding IDA 19764817
GO:0005515 protein binding IPI 23349812
GO:0008131 primary amine oxidase activity TAS --
genes like me logo Genes that share ontologies with AOC3: view
genes like me logo Genes that share phenotypes with AOC3: view

Animal Models for AOC3 Gene

MGI Knock Outs for AOC3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AOC3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for AOC3 Gene

Localization for AOC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AOC3 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AOC3 Gene COMPARTMENTS Subcellular localization image for AOC3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
endosome 4
golgi apparatus 4
cytosol 2
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for AOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23349812
GO:0005769 early endosome IDA 23474851
GO:0005783 endoplasmic reticulum IDA 23474851
GO:0005794 Golgi apparatus IDA 23474851
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with AOC3: view

Pathways & Interactions for AOC3 Gene

genes like me logo Genes that share pathways with AOC3: view

Pathways by source for AOC3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for AOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0006812 cation transport --
GO:0006954 inflammatory response TAS 9653080
GO:0007155 cell adhesion IDA 9653080
GO:0009308 amine metabolic process IDA 9653080
genes like me logo Genes that share ontologies with AOC3: view

No data available for SIGNOR curated interactions for AOC3 Gene

Drugs & Compounds for AOC3 Gene

(35) Drugs for AOC3 Gene - From: NovoSeek, HMDB, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydralazine Approved Pharma inhibitor, Target 41
Phenelzine Approved Pharma inhibitor, Target 6
Dopamine Approved Pharma Full agonist, Agonist 2814
Epinephrine Approved Pharma 768
hydroxyproline Approved, Experimental Pharma 0

(46) Additional Compounds for AOC3 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
aminoacetone
  • 1-Amino-(8CI,9CI)-2-propanone
  • 1-Amino-2-propanone
  • 1-Aminopropan-2-one
  • alpha-Aminoacetone
  • Amino-(6CI)-2-propanone
298-08-8
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Quinone
  • 1,4-Benzoquine
  • 1,4-Benzoquinone
  • 1,4-Cyclohexadiene dioxide
  • 1,4-Cyclohexadienedione
  • 1,4-Diossibenzene
106-51-4
1,3-diaminopropane
  • 1,3-Diamino-N-propane
  • 1,3-Propanediamine
  • 1,3-Propylenediamine
  • 1,3-Trimethylenediamine
  • 3-Aminopropylamine
109-76-2
1-Methylpyrrolinium
genes like me logo Genes that share compounds with AOC3: view

Transcripts for AOC3 Gene

Unigene Clusters for AOC3 Gene

Amine oxidase, copper containing 3 (vascular adhesion protein 1):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AOC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AOC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - - -
SP2: - - -
SP3:
SP4: - - - - -
SP5:
SP6:

Relevant External Links for AOC3 Gene

GeneLoc Exon Structure for
AOC3
ECgene alternative splicing isoforms for
AOC3

Expression for AOC3 Gene

mRNA expression in normal human tissues for AOC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AOC3 Gene

This gene is overexpressed in Artery - Tibial (x5.4), Artery - Aorta (x4.4), Artery - Coronary (x4.4), and Adipose - Subcutaneous (x4.0).

Protein differential expression in normal tissues from HIPED for AOC3 Gene

This gene is overexpressed in Adipocyte (25.0) and Nasopharynx (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AOC3 Gene



SOURCE GeneReport for Unigene cluster for AOC3 Gene Hs.198241

mRNA Expression by UniProt/SwissProt for AOC3 Gene

Q16853-AOC3_HUMAN
Tissue specificity: Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung.
genes like me logo Genes that share expression patterns with AOC3: view

Protein tissue co-expression partners for AOC3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for AOC3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AOC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AOC3 35
  • 86.89 (n)
  • 85.19 (a)
-- 36
  • 80 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia AOC3 35
  • 88.86 (n)
  • 88.86 (a)
AOC3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aoc3 35
  • 83.99 (n)
  • 83.2 (a)
Aoc3 16
Aoc3 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AOC3 35
  • 99.04 (n)
  • 99.21 (a)
AOC3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aoc3 35
  • 82.87 (n)
  • 82.44 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves AOC3 35
  • 63.32 (n)
  • 56.63 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia aoc3 35
  • 56.52 (n)
  • 53.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9482 35
zebrafish
(Danio rerio)
Actinopterygii aoc2 35
  • 52.64 (n)
  • 42.49 (a)
aoc2 36
  • 41 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU09406 35
  • 44.06 (n)
  • 29.19 (a)
Species with no ortholog for AOC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AOC3 Gene

ENSEMBL:
Gene Tree for AOC3 (if available)
TreeFam:
Gene Tree for AOC3 (if available)

Paralogs for AOC3 Gene

Paralogs for AOC3 Gene

(3) SIMAP similar genes for AOC3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for AOC3 Gene

genes like me logo Genes that share paralogs with AOC3: view

Variants for AOC3 Gene

Sequence variations from dbSNP and Humsavar for AOC3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs573746113 -- 42,854,933(+) CCTCC(A/G)CCTCC intron-variant
rs574110621 -- 42,851,558(+) TGTGA(A/T)GCGCT missense, reference, upstream-variant-2KB, nc-transcript-variant
rs574123445 -- 42,854,704(+) AACAG(C/T)TCCAT reference, synonymous-codon, nc-transcript-variant
rs573304904 -- 42,852,805(+) AAATA(A/C/T)GATTC synonymous-codon, reference, stop-gained, upstream-variant-2KB, nc-transcript-variant
rs573088630 -- 42,858,344(+) ACACA(C/T)ACCCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for AOC3 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv483009 CNV Gain 15286789

Variation tolerance for AOC3 Gene

Residual Variation Intolerance Score: 85.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.10; 75.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AOC3 Gene

HapMap Linkage Disequilibrium report
AOC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AOC3 Gene

Disorders for AOC3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for AOC3 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
perinephritis
microvascular complications of diabetes 5
  • diabetic retinopathy
congestive heart failure
  • chf
diabetes mellitus, insulin-dependent
  • diabetes, type 1
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
- elite association
Search AOC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AOC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AOC3
genes like me logo Genes that share disorders with AOC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AOC3 Gene

Publications for AOC3 Gene

  1. Semicarbazide-sensitive amine oxidase: role in the vasculature and vasodilation after in situ inhibition. (PMID: 15255812) Vidrio H. (Auton Autacoid Pharmacol 2003) 23 25 26 67
  2. Involvement of semicarbazide-sensitive amine oxidase in tresperimus metabolism in human and in rat. (PMID: 11302941) Claud P. … LainAc R. (Drug Metab. Dispos. 2001) 23 25 26 67
  3. Autoradiographic imaging of formaldehyde adducts in mice: possible relevance for vascular damage in diabetes. (PMID: 9740313) GrAPnvall J.L. … Ekblom J. (Life Sci. 1998) 23 25 26 67
  4. Localization of vascular adhesion protein-1 (VAP-1) in the human eye. (PMID: 19761765) Almulki L. … Hafezi-Moghadam A. (Exp. Eye Res. 2010) 23 67
  5. Changes in the activities of semicarbazide-sensitive amine oxidase in inferior mesenteric artery segments and in serum of patients with type 2 diabetes. (PMID: 20063021) Nunes S.F. … Callingham B. (Acta Diabetol 2010) 23 67

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