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AOC3 Gene

protein-coding   GIFtS: 63
GCID: GC17P041003

Amine Oxidase, Copper Containing 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Amine Oxidase, Copper Containing 31 2     VAP-12 3
HPAO2 3 5     EC 1.4.3.213 8
VAP12 3 5     Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1)2
Vascular Adhesion Protein 11 3     Membrane Primary Amine Oxidase2
Copper Amine Oxidase2 3     Placenta Copper Monamine Oxidase2
Semicarbazide-Sensitive Amine Oxidase2 3     EC 1.4.38
SSAO2 3     

External Ids:    HGNC: 5501   Entrez Gene: 86392   Ensembl: ENSG000001314717   OMIM: 6037355   UniProtKB: Q168533   

Export aliases for AOC3 gene to outside databases

Previous GC identifers: GC17M040621 GC17P043165 GC17P040911 GC17P041376 GC17P038256 GC17P036767


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AOC3 Gene:
This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the
oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein
is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be
involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many
diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately
9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Apr 2013)

GeneCards Summary for AOC3 Gene:
AOC3 (amine oxidase, copper containing 3) is a protein-coding gene. Diseases associated with AOC3 include coronary artery vasospasm, and dissecting aortic aneurysm. GO annotations related to this gene include protein heterodimerization activity and calcium ion binding. An important paralog of this gene is AOC1.

UniProtKB/Swiss-Prot: AOC3_HUMAN, Q16853
Function: Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the
binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion.
Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis

Gene Wiki entry for AOC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the AOC3 gene promoter:
         p53   AP-1   ATF-2   NF-kappaB1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAOC3 promoter sequence
   Search Chromatin IP Primers for AOC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AOC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21

AOC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AOC3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P041003:  view genomic region     (about GC identifiers)

Start:
41,003,201 bp from pter      End:
41,010,147 bp from pter
Size:
6,947 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AOC3_HUMAN, Q16853 (See protein sequence)
Recommended Name: Membrane primary amine oxidase  
Size: 763 amino acids; 84622 Da
Cofactor: Binds 1 copper ion per subunit
Cofactor: Binds 2 calcium ions per subunit
Cofactor: Contains 1 topaquinone per subunit
Subunit: Homodimer; disulfide-linked. Can heterodimerize with isoform 2 leading to reduced surface expression.
Forms a heterodimer with AOC2
Selected PDB 3D structures from and Proteopedia for AOC3 (see all 10):
1PU4 (3D)        1US1 (3D)        2C10 (3D)        2C11 (3D)        2Y73 (3D)        2Y74 (3D)    
Secondary accessions: B2RCI5 L0L8N9 Q45F94
Alternative splicing: 2 isoforms:  Q16853-1   Q16853-2   (Devoid of the semicarbazide-sensitive amine oxidase (SSAO) activity)

Explore the universe of human proteins at neXtProt for AOC3: NX_Q16853

Explore proteomics data for AOC3 at MOPED

Post-translational modifications: 

  • Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue1
  • N- and O-glycosylated1
  • Glycosylation2 at Asn137, Thr212, Asn232, Asn294, Asn592, Asn618, Asn666
  • Selected DME Specific Peptides for AOC3 (Q16853) (see all 17)
     EELTAVM  PRYLYLA  DLVAWVT  SADSIYF 


    See AOC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001264660.1  NP_001264661.1  NP_003725.1  

    ENSEMBL proteins: 
     ENSP00000312326   ENSP00000464787   ENSP00000465913   ENSP00000468632   ENSP00000468043  

    AOC3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for AOC3
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    Novus Biologicals AOC3 Proteins
    Novus Biologicals AOC3 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for AOC3

    AOC3 Antibody Products:

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    Cloud-Clone Corp. ELISAs for AOC3
    Cloud-Clone Corp. CLIAs for AOC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR015800 Cu_amine_oxidase_N2
     IPR016182 Cu_amine_oxidase_N-reg
     IPR015802 Cu_amine_oxidase_N3
     IPR015801 Cu_amine_oxidase_N2/3
     IPR000269 Cu_amine_oxidase

    Graphical View of Domain Structure for InterPro Entry Q16853

    ProtoNet protein and cluster: Q16853

    1 Blocks protein domain: IPB000269 Copper amine oxidase

    UniProtKB/Swiss-Prot: AOC3_HUMAN, Q16853
    Similarity: Belongs to the copper/topaquinone oxidase family


    AOC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AOC3_HUMAN, Q16853
    Function: Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the
    binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion.
    Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis
    Catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
    Biophysicochemical properties: Kinetic parameters: KM=1.94 mM for 2-phenylethylamine; KM=0.67 mM for methylamine;
    Induction: Up-regulated during in vitro adipocyte differentiation

         Genatlas biochemistry entry for AOC3:
    amine oxidase,copper containing 3,endothelial sialoglycoprotein induced under inflammatory conditions,mediating
    tissue selective lymphocyte binding

         Enzyme Numbers (IUBMB): EC 1.4.3.211 2 EC 1.4.32

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005261cation channel activity IDA19764817
    GO:0005507copper ion binding IDA19764817
    GO:0005509calcium ion binding IDA19764817
    GO:0005515protein binding IPI--
    GO:0008131primary amine oxidase activity IDA19764817
         
    AOC3 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Aoc3):
     cellular  hematopoietic system  immune system 

    AOC3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Aoc3tm1Salm for AOC3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AOC3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AOC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AOC3

    miRNA
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    Block miRNA regulation of human, mouse, rat AOC3 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate AOC3:
    hsa-miR-3150b-3p hsa-miR-558 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidAOC3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AOC3
    Predesigned siRNA for gene silencing in human, mouse, rat AOC3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for AOC3

    Clone
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    OriGene clones in human, mouse for AOC3 (see all 6)
    OriGene ORF clones in mouse, rat for AOC3
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    GenScript: all cDNA clones in your preferred vector: AOC3 (NM_003734)
    Sino Biological Human cDNA Clone for AOC3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AOC3

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AOC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AOC3_HUMAN, Q16853: Cell membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    endoplasmic reticulum2
    extracellular2
    golgi apparatus2
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA9653080
    GO:0005902microvillus IDA--
    GO:0009986cell surface IDA--
    GO:0016021integral component of membrane IDA9653080

    AOC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AOC3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1beta-Alanine metabolism
    beta-Alanine metabolism
    phenylethylamine degradation I0.00
    2Phenylalanine metabolism
    Phenylalanine metabolism0.36
    Tyrosine metabolism0.36
    3Metabolism
    Metabolic pathways0.38
    4Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    5Tyrosine metabolism p.1 dopamine
    Tyrosine metabolism p.1 dopamine

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AOC3
        Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for AOC3
        Tyrosine metabolism p.1 (dopamine)

    2 BioSystems Pathways for AOC3
        spermine and spermidine degradation I
    phenylethylamine degradation I



    5 Kegg Pathways  (Kegg details for AOC3):
        Glycine, serine and threonine metabolism
    Tyrosine metabolism
    Phenylalanine metabolism
    beta-Alanine metabolism
    Metabolic pathways


    AOC3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including AOC3: 
              Amino Acid Metabolism II in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AOC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for AOC3 (Q168533 ENSP000003123264) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VAV1P154983, ENSP000003022694I2D: score=1 STRING: ENSP00000302269
    ALDH2ENSP000002617334STRING: ENSP00000261733
    ALDH3A1ENSP000002257404STRING: ENSP00000225740
    COMTENSP000003545114STRING: ENSP00000354511
    DBHENSP000003767764STRING: ENSP00000376776
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport IDA19764817
    GO:0006954inflammatory response TAS9653080
    GO:0007155cell adhesion IDA9653080
    GO:0009308amine metabolic process IDA9653080
    GO:0046677response to antibiotic IDA19764817

    AOC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AOC3

    Selected HMDB Compounds for AOC3 (see all 21)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1,3-Diaminopropane1,3-Diamino-n-propane (see all 8)109-76-2--
    1-Phenylethylaminea-phenylethylamine (see all 17)98-84-0--
    3,4-DihydroxyphenylacetaldehydeProtocatechuatealdehyde (see all 2)5707-55-1--
    5-Aminopentanal5-Amino-pentanal ----
    Aminoacetone1-Amino-2-propanone (see all 6)298-08-8--
    AmmoniaNH3 (see all 31)7664-41-7--
    Cadaverine1,5-Diaminopentane (see all 9)462-94-2--
    CalciumCa (see all 2)7440-70-2--
    CopperCu (see all 2)7440-50-8--
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--

    3 DrugBank Compounds for AOC3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Hydralazine-- 86-54-4targetinhibitor16116337 4091799 9740313 15255812 17385063 6150080 12970383 2568436 8694842 11061213 11302941
    Phenelzine-- 51-71-8targetinhibitor17768678 9570326 1483111 8539478 8694842 19201819
    6-hydroxydopa quinone2,4,5-trihydroxyphenylalanine quinone (see all 4)--target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for AOC3 gene (see all 63)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminoacetone 96.1 32 10328770 (6), 1567465 (4), 7634751 (1), 16487546 (1) (see all 16)
    amine 93.3 630 11052858 (9), 10369802 (7), 7634751 (6), 10064104 (5) (see all 99)
    semicarbazide 93.3 102 12213997 (4), 14715500 (4), 17095030 (3), 11302941 (3) (see all 35)
    benzylamine 92.6 55 17989349 (3), 16135411 (3), 12663473 (3), 17548204 (2) (see all 29)
    methylamine 92 94 8454111 (7), 14715500 (5), 12213997 (4), 7931256 (3) (see all 43)
    topaquinone 91.8 18 9492272 (2), 8886285 (2), 10853675 (2), 8524151 (1) (see all 9)
    tresperimus 77.2 13 12019205 (4), 11302941 (3)
    methylglyoxal 76.8 18 17074066 (1), 1567465 (1), 7931255 (1), 9572061 (1) (see all 11)
    tyramine 71.6 15 19588076 (1), 11561068 (1), 16180332 (1), 17868200 (1) (see all 10)
    allylamine 70.9 24 11543647 (4), 17095030 (2), 2104785 (2), 9503571 (1) (see all 6)



    AOC3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AOC3 gene (3 alternative transcripts): 
    NM_001277731.1  NM_001277732.1  NM_003734.3  

    Unigene Cluster for AOC3:

    Amine oxidase, copper containing 3 (vascular adhesion protein 1)
    Hs.198241  [show with all ESTs]
    Unigene Representative Sequence: BC036368
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308423(uc002ibv.3) ENST00000587330 ENST00000592999 ENST00000591562
    ENST00000588033

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate AOC3:
    hsa-miR-3150b-3p hsa-miR-558 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidAOC3 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for AOC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AOC3
      QuantiTect SYBR Green Assays in human, mouse, rat AOC3
      QuantiFast Probe-based Assays in human, mouse, rat AOC3

    Additional mRNA sequence: 

    AF054985.1 AF067406.1 AK025727.1 AK315129.1 BC036368.1 BC050549.1 JX020506.1 U39447.1 

    6 DOTS entries:

    DT.445264  DT.100778352  DT.120953952  DT.100778351  DT.120953959  DT.40131963 

    Selected AceView cDNA sequences (see all 122):

    AI458535 BM823391 BQ878960 AI611299 F09280 BP338190 BF437267 BM973838 
    CD244750 BP373105 BU520834 AI129246 BC050549 BC036368 AA563791 U39447 
    NM_003734 CA391310 BM831002 AI682550 BM831093 BU679723 AK025727 AF047485 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AOC3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
    SP1:                          -     -     -     -                                       
    SP2:                                -     -     -                                       
    SP3:                                                                                    
    SP4:                          -     -     -     -     -                                 
    SP5:                                                                                    


    ECgene alternative splicing isoforms for AOC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AOC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACTGTATT
    AOC3 Expression
    About this image


    AOC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Liver (Hepatobiliary System)
             Sinusoidal Endothelial Cells Sinusoids
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
    AOC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AOC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.198241

    UniProtKB/Swiss-Prot: AOC3_HUMAN, Q16853
    Tissue specificity: Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic
    endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in
    bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis.
    Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest
    relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung

        Pathway & Disease-focused RT2 Profiler PCR Array including AOC3: 
              Amino Acid Metabolism II in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AOC3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aoc31 , 5 amine oxidase, copper containing 31, 5 83.99(n)1
    83.2(a)1
      11 (64.72 cM)5
    117541  NM_009675.21  NP_033805.11 
     1013306055 
    chicken
    (Gallus gallus)
    Aves AOC31 amine oxidase, copper containing 3 63.32(n)
    56.63(a)
      420015  XM_004948624.1  XP_004948681.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Amine oxidase
    (see all 3)
    60(a)
    50(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    6(62395837-62405196)
    6(62355879-62372988)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.94822 Xenopus laevis transcribed sequence with weak similarity more 74.15(n)    CD324731.1 
    zebrafish
    (Danio rerio)
    Actinopterygii aoc21 amine oxidase, copper containing 2 52.64(n)
    42.49(a)
      541429  NM_001013555.3  NP_001013573.3 


    ENSEMBL Gene Tree for AOC3 (if available)
    TreeFam Gene Tree for AOC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AOC3 gene
    AOC12  AOC22  
    3 SIMAP similar genes for AOC3 using alignment to 5 protein entries:     AOC3_HUMAN (see all proteins):
    AOC2    ABP1    AOC1

    AOC3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AOC3
    PGOHUM00000237400


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AOC3 (see all 287)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1482750431,2
    --41003267(+) CCCCCC/TACCCC 4 -- ut51 us2k1 nc-transcript-variant0--------
    rs339681761,2
    C,F--41003337(+) TTGAAT/GCAGCT 4 -- ut51 us2k1 nc-transcript-variant12Minor allele frequency- G:0.00NS NA 380
    rs1997485171,2
    C--41003353(+) TCTTCA/GTGGGA 4 -- ut51 us2k1 nc-transcript-variant0--------
    rs339542111,2,,4
    C,F--41003374(+) GAAGAA/C/GAATCC 9 K T R mis1 us2k113NS NA EU 1695
    rs1387253491,2
    C,F--41003381(+) ATCCTC/TGTGCT 6 L syn1 us2k11Minor allele frequency- T:0.00NA 4552
    rs1507966671,2
    C--41003400(+) TGGCCA/GTCATC 6 I V mis1 us2k10--------
    rs2018476501,2
    --41003479(+) TCCCCA/GTTGCC 6 H R mis1 us2k10--------
    rs1894106191,2
    --41003522(+) CACCCC/TGGCCA 6 P syn1 us2k10--------
    rs2010461181,2
    --41003565(+) AGCTGA/GCGGCT 6 T A mis1 us2k10--------
    rs4026801,2,,4
    C--41003593(-) CCAGCC/TGCTGG 6 Q R mis1 us2k1 ese34Minor allele frequency- T:0.03NA MN 4634

    HapMap Linkage Disequilibrium report for AOC3 (41003201 - 41010147 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AOC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv483009CNV Gain15286789
    esv33998OTHER Inversion15654335

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AOC3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603735    OMIM disorders: --

    Selected diseases for AOC3 (see all 55):    
    About MalaCards
    coronary artery vasospasm    dissecting aortic aneurysm    uremia    skin melanoma
    relapsing-remitting multiple sclerosis    cerebral amyloid angiopathy    vascular dementia    hypertensive heart disease
    diabetic angiopathy    diabetes mellitus    hyperglycemia    congestive heart failure
    wegener's granulomatosis    morbid obesity    vascular disease    type 1 diabetes mellitus
    diabetic retinopathy    multiple sclerosis    liver cirrhosis    skin disease

    1 disease from the University of Copenhagen DISEASES database for AOC3:
    Diabetes mellitus

    AOC3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for AOC3 gene (see all 43)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetic angiopathies 52 2 10892891 (1), 12466139 (1)
    inflammation 45.5 57 18032635 (3), 8245796 (3), 19789505 (3), 11461168 (2) (see all 26)
    cerebral amyloid angiopathy 38 1 17971074 (1)
    vascular diseases 36.6 10 12686132 (2), 17074066 (1), 18644360 (1), 9074703 (1) (see all 9)
    diabetes mellitus 31.3 19 7634751 (2), 12686114 (2), 18644360 (1), 9920154 (1) (see all 13)
    atherosclerosis 30.5 11 10892891 (4), 16487546 (1), 11052858 (1), 15035818 (1) (see all 7)
    retinopathy 27.2 15 10391401 (6), 11522499 (3), 12532650 (2), 7634751 (1)
    heart failure congestive 25.3 13 15134520 (1), 12686107 (1), 9074703 (1), 14977883 (1) (see all 9)
    atherosclerotic plaque 22.6 1 9885324 (1)
    diabetic retinopathy 22.4 6 12532650 (4), 10391401 (1), 11522499 (1)


    Export disorders for AOC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AOC3 gene, integrated from 10 sources (see all 324):
    (articles sorted by number of sources associating them with AOC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule. (PubMed id 9653080)1, 2, 3 Smith D.J.... Jalkanen S. (J. Exp. Med. 1998)
    2. Cloning and sequencing of a copper-containing, topaquinone-containing monoamine oxidase from human placenta. (PubMed id 8972912)1, 2, 3 Zhang X. and McIntire W.S. (Gene 1996)
    3. Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes. (PubMed id 17400359)1, 2, 9 Bour S.... Carpene C. (Biochimie 2007)
    4. Characterization of AOC2 gene encoding a copper-binding amine oxidase expressed specifically in retina. (PubMed id 14585497)1, 2, 9 Zhang Q.... Iwata T. (Gene 2003)
    5. Functional modulation of vascular adhesion protein-1 by a novel splice variant. (PubMed id 23349812)1, 2 Kaitaniemi S.... Elima K. (PLoS ONE 2013)
    6. Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications. (PubMed id 16046623)1, 2 Airenne T.T.... Salminen T.A. (Protein Sci. 2005)
    7. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    8. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)1, 2 Aboulaich N.... Vener A.V. (Biochem. J. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Localization of vascular adhesion protein-1 (VAP-1) in the human eye. (PubMed id 19761765)1, 9 Almulki L....Hafezi-Moghadam A. (Exp. Eye Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8639 HGNC: 550 AceView: AOC3 Ensembl:ENSG00000131471 euGenes: HUgn8639
    ECgene: AOC3 Kegg: 8639 H-InvDB: AOC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AOC3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/aoc3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AOC3 gene:
    Search GeneIP for patents involving AOC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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