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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AOC2 Gene

protein-coding   GIFtS: 58
GCID: GC17P040996

Amine Oxidase, Copper Containing 2 (Retina-Specific)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Amine Oxidase, Copper Containing 2 (Retina-Specific)1 2     Retina-Specific Copper Amine Oxidase2
RAO2 3 5     EC 1.4.3.213
Semicarbazide-Sensitive Amine Oxidase2 3     Amine Oxidase [Copper-Containing]3
SSAO2 3     EC 1.4.38
DAO22     

External Ids:    HGNC: 5491   Entrez Gene: 3142   Ensembl: ENSG000001314807   OMIM: 6022685   UniProtKB: O751063   

Export aliases for AOC2 gene to outside databases

Previous GC identifers: GC17M040628 GC17P043158 GC17P040905 GC17P041369 GC17P038250 GC17P036761


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AOC2 Gene:
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of
copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various
species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site
of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal
transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene
may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for AOC2 Gene: 
AOC2 (amine oxidase, copper containing 2 (retina-specific)) is a protein-coding gene. Diseases associated with AOC2 include dissecting aortic aneurysm, and chorioretinitis, and among its related super-pathways are Tyrosine metabolism and Tyrosine metabolism p.1 (dopamine) . GO annotations related to this gene include electron carrier activity and quinone binding. An important paralog of this gene is AOC1.

UniProtKB/Swiss-Prot: AOC2_HUMAN, O75106
Function: Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May
play a role in adipogenesis. May be a critical modulator of signal transmission in retina




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AOC2 gene promoter:
         p53   AP-1   ATF-2   NF-kappaB1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAOC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AOC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AOC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21

AOC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AOC2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040996:  view genomic region     (about GC identifiers)

Start:
40,996,609 bp from pter      End:
41,002,724 bp from pter
Size:
6,116 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AOC2_HUMAN, O75106 (See protein sequence)
Recommended Name: Retina-specific copper amine oxidase precursor  
Size: 756 amino acids; 83673 Da
Cofactor: Binds 1 copper ion per subunit (By similarity)
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Cofactor: Contains 1 topaquinone per subunit (By similarity)
Subunit: Forms a heterodimer with AOC3, in vitro
Subcellular location: Isoform 1: Cell membrane; Peripheral membrane protein. Note=Present on the surface of the
cells
Subcellular location: Isoform 2: Cytoplasm. Note=Either not translocated to the plasma membrane or below detection
level
Secondary accessions: A5PKW2 O00120 O75105 Q4TTW5 Q9UNY0
Alternative splicing: 2 isoforms:  O75106-1   O75106-2   

Explore the universe of human proteins at neXtProt for AOC2: NX_O75106

Explore proteomics data for AOC2 at MOPED 

Post-translational modifications:

  • UniProtKB: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75106

  • 4/10 DME Specific Peptides for AOC2 (O75106) (see all 10)
     NYDYIWD  EELTAVM  PRYLYLA  SWGRYQL 

    AOC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AOC2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001149.2  NP_033720.2  

    ENSEMBL proteins: 
     ENSP00000253799   ENSP00000406134  

    Human Recombinant Protein Products for AOC2: 
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    Cloud-Clone Corp. Proteins for AOC2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--

    AOC2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR015800 Cu_amine_oxidase_N2
     IPR015802 Cu_amine_oxidase_N3
     IPR016182 Cu_amine_oxidase_N-reg
     IPR015801 Cu_amine_oxidase_N2/3
     IPR000269 Cu_amine_oxidase

    Graphical View of Domain Structure for InterPro Entry O75106

    ProtoNet protein and cluster: O75106

    1 Blocks protein domain: IPB000269 Copper amine oxidase

    UniProtKB/Swiss-Prot: AOC2_HUMAN, O75106
    Similarity: Belongs to the copper/topaquinone oxidase family


    AOC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AOC2_HUMAN, O75106
    Function: Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May
    play a role in adipogenesis. May be a critical modulator of signal transmission in retina
    Catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
    Biophysicochemical properties: Kinetic parameters: KM=0.056 mM for tryptamine; KM=0.077 mM for 2-phenylethylamine;
    KM=0.167 mM for benzylamine; KM=0.178 mM for p-tyramine; KM=1.7 mM for methylamine;
    Induction: Up-regulated during in vitro adipocyte differentiation

         Genatlas biochemistry entry for AOC2:
    amine oxidase,copper containing 2,retina specific,with two alternatively spliced isoforms

         Enzyme Numbers (IUBMB): EC 1.4.3.211 EC 1.4.32

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding IEA--
    GO:0008131primary amine oxidase activity IEA--
    GO:0009055electron carrier activity TAS9119395
    GO:0048038quinone binding IEA--
    GO:0052593tryptamine:oxygen oxidoreductase (deaminating) activity IEA--
         
    AOC2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AOC2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AOC2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AOC2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Phenylalanine metabolism
    Phenylalanine metabolism0.36
    Tyrosine metabolism0.36
    2Tyrosine metabolism p.1 (dopamine)
    Tyrosine metabolism p.1 (dopamine)1.00
    3Metabolism
    Metabolic pathways0.40
    4phenylethylamine degradation I
    phenylethylamine degradation I
    5histamine degradation
    histamine degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for AOC2
        Tyrosine metabolism p.1 (dopamine)


    1 GeneGo (Thomson Reuters) Pathway for AOC2
        Tyrosine metabolism p.1 (dopamine)

    2 BioSystems Pathways for AOC2
        histamine degradation
    phenylethylamine degradation I


    5         Kegg Pathways  (Kegg details for AOC2):
        Glycine, serine and threonine metabolism
    Tyrosine metabolism
    Phenylalanine metabolism
    beta-Alanine metabolism
    Metabolic pathways


    AOC2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AOC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/15 Interacting proteins for AOC2 (ENSP000002537994) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COMTENSP000003545114STRING: ENSP00000354511
    DBHENSP000003767764STRING: ENSP00000376776
    DDCENSP000003506164STRING: ENSP00000350616
    ALDH1A3ENSP000003322564STRING: ENSP00000332256
    ALDH1B1ENSP000003669274STRING: ENSP00000366927
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006584catecholamine metabolic process IEA--
    GO:0007601visual perception TAS9119395
    GO:0009308amine metabolic process IEA--
    GO:0055114oxidation-reduction process ----

    AOC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AOC2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for AOC2

    10/21 HMDB Compounds for AOC2 (see all 21)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1,3-Diaminopropane1,3-Diamino-n-propane (see all 8)109-76-2--
    1-Phenylethylaminea-phenylethylamine (see all 17)98-84-0--
    3,4-DihydroxyphenylacetaldehydeProtocatechuatealdehyde (see all 2)5707-55-1--
    Aminoacetone1-Amino-2-propanone (see all 6)298-08-8--
    AmmoniaNH3 (see all 31)7664-41-7--
    Cadaverine1,5-Diaminopentane (see all 9)462-94-2--
    CalciumCa (see all 2)7440-70-2--
    CopperCu (see all 2)7440-50-8--
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--
    FormaldehydeAldeide formica (see all 16)50-00-0--

    1 Novoseek inferred chemical compound relationship for AOC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amine 52 6 14585497 (3)

    Search CenterWatch for drugs/clinical trials and news about AOC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AOC2 gene (2 alternative transcripts): 
    NM_001158.3  NM_009590.2  

    Unigene Cluster for AOC2:

    Amine oxidase, copper containing 2 (retina-specific)
    Hs.143102  [show with all ESTs]
    Unigene Representative Sequence: NM_009590
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253799(uc002ibu.3) ENST00000452774(uc002ibt.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AF081363.1 BC142641.1 D88213.1 

    2 DOTS entries:

    DT.100740715  DT.100021332 

    20 AceView cDNA sequences:

    AF081363 CA397128 CA391266 CA389197 BM711998 CA393704 BM719996 NM_009590 
    N50959 CA425343 CA395002 NM_001158 BQ002453 D88213 BX116991 BM675947 
    CA427935 BF986543 BG108394 AW890286 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for AOC2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for AOC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AOC2 expression in normal human tissues (normalized intensities)      AOC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCATTCAAA
    AOC2 Expression
    About this image


    AOC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced 4D20.8 cells
             fetal cartilage   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Testis (Reproductive System)
             sperm   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Blood (Hematopoietic System)
             neutrophils   

    See AOC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AOC2

    SOURCE GeneReport for Unigene cluster: Hs.143102

    UniProtKB/Swiss-Prot: AOC2_HUMAN, O75106
    Tissue specificity: Expressed in many tissues with much higher expression in retina. Isoform 1 and isoform 2 are
    expressed in adipose tissue, whereas isoform 1 only seems to be present in thymus, and isoform 2 only in testis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AOC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AOC2 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aoc21 , 5 amine oxidase, copper containing 2 (retina-specific)1, 5 83.18(n)1
    81.06(a)1
      11 (64.70 cM)5
    2379401  NM_178932.11  NP_849263.11 
     1013250635 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Amine oxidase
    (see all 3)
    57(a)
    47(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    6(62395837-62405196)
    6(62355879-62372988)
    zebrafish
    (Danio rerio)
    Actinopterygii AOC26
    amine oxidase, copper containing 2 (retina-specifi...
    43(a)
    1 → many
    3(33061160-33071335)


    ENSEMBL Gene Tree for AOC2 (if available)
    TreeFam Gene Tree for AOC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AOC2 gene
    AOC12  AOC32  
    2 SIMAP similar genes for AOC2 using alignment to 1 protein entry:     AOC2_HUMAN:
    AOC3    ABP1

    AOC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/200 SNPs in AOC2 are shown (see all 200)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs44931151,2
    H--40996285(-) CCTCAG/TATGCC 2 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1460243811,2
    --40996341(+) GCATCA/GTTAAC 2 -- us2k10--------
    rs1398307751,2
    --40996366(+) ATCTGC/GTCTAA 2 -- us2k10--------
    rs1179428551,2
    F--40996368(+) CTGGTC/GTAAAT 2 -- us2k11Minor allele frequency- G:0.01EA 120
    rs352440311,2
    C--40996476(+) GGACAG/CAAAAT 2 -- us2k16Minor allele frequency- C:0.01NS EA 310
    rs169680381,2
    C,F,H--40996563(+) ATCCTA/GGCGAA 2 -- us2k128Minor allele frequency- G:0.06NA EA NS 2732
    rs1931245291,2
    --40996566(+) CTAGCA/GAATAT 2 -- us2k10--------
    rs1855500921,2
    --40996577(+) AAACCC/TCGACT 2 -- us2k10--------
    rs351544331,2
    C--40996617(+) TAGAAT/CTCTGA 2 -- ut516Minor allele frequency- C:0.04NS WA 308
    rs1420427481,2
    C,F--40996642(+) ATCCAC/ACATGC 2 -- ut512Minor allele frequency- A:0.00NA EU 5615

    HapMap Linkage Disequilibrium report for AOC2 (40996609 - 41002724 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AOC2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv483009CNV Gain15286789
    esv33998OTHER Inversion15654335

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602268    OMIM disorders: --

    4 diseases for AOC2:    About MalaCards
    dissecting aortic aneurysm    chorioretinitis    aortic aneurysm    diabetes mellitus

    2 diseases from the University of Copenhagen DISEASES database for AOC2:
    Dissecting aortic aneurysm     Diabetes mellitus

    AOC2 for disorders           About GeneDecksing


    Export disorders for AOC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AOC2 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with AOC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human retina-specific amine oxidase: genomic structure of the gene (AOC2), alternatively spliced variant, and mRNA expression in retina. (PubMed id 9722954)1, 2, 3, 9 Imamura Y.... Shimizu N. (1998)
    2. Human retina-specific amine oxidase (RAO): cDNA cloning, tissue expression, and chromosomal mapping. (PubMed id 9119395)1, 2, 3, 9 Imamura Y.... Shimizu N. (1997)
    3. The unique substrate specificity of human AOC2, a semicarbazide- sensitive amine oxidase. (PubMed id 19588076)1, 2 Kaitaniemi S.... Elima K. (2009)
    4. Characterization of AOC2 gene encoding a copper-binding amine oxidase expressed specifically in retina. (PubMed id 14585497)1, 9 Zhang Q.... Iwata T. (2003)
    5. Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes. (PubMed id 17400359)2 Bour S.... Carpene C. (2007)
    6. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    9. High expression of semicarbazide-sensitive amine oxidase genes AOC2 and AOC3, but not the diamine oxidase gene AOC1 in human adipocytes. (PubMed id 12755418)2 Heniquez A.... Carpene C. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 314 HGNC: 549 AceView: AOC2 Ensembl:ENSG00000131480 euGenes: HUgn314
    ECgene: AOC2 Kegg: 314 H-InvDB: AOC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AOC2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/aoc2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AOC2 gene:
    Search GeneIP for patents involving AOC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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