Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AOC2 Gene

protein-coding   GIFtS: 58
GCID: GC17P040996

Amine Oxidase, Copper Containing 2 (Retina-Specific)

  See AOC2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Amine Oxidase, Copper Containing 2 (Retina-Specific)1 2     Retina-Specific Copper Amine Oxidase2
RAO2 3 5     EC 1.4.3.213
Semicarbazide-Sensitive Amine Oxidase2 3     Amine Oxidase [Copper-Containing]3
SSAO2 3     EC 1.4.38
DAO22     

External Ids:    HGNC: 5491   Entrez Gene: 3142   Ensembl: ENSG000001314807   OMIM: 6022685   UniProtKB: O751063   

Export aliases for AOC2 gene to outside databases

Previous GC identifers: GC17M040628 GC17P043158 GC17P040905 GC17P041369 GC17P038250 GC17P036761


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for AOC2 Gene:
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of
copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various
species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site
of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal
transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene
may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for AOC2 Gene:
AOC2 (amine oxidase, copper containing 2 (retina-specific)) is a protein-coding gene. Diseases associated with AOC2 include dissecting aortic aneurysm. GO annotations related to this gene include electron carrier activity and quinone binding. An important paralog of this gene is AOC1.

UniProtKB/Swiss-Prot: AOC2_HUMAN, O75106
Function: Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May
play a role in adipogenesis. May be a critical modulator of signal transmission in retina




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the AOC2 gene promoter:
         p53   AP-1   ATF-2   NF-kappaB1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAOC2 promoter sequence
   Search Chromatin IP Primers for AOC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AOC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21

AOC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AOC2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040996:  view genomic region     (about GC identifiers)

Start:
40,996,609 bp from pter      End:
41,002,724 bp from pter
Size:
6,116 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AOC2_HUMAN, O75106 (See protein sequence)
Recommended Name: Retina-specific copper amine oxidase precursor  
Size: 756 amino acids; 83673 Da
Cofactor: Binds 1 copper ion per subunit (By similarity)
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Cofactor: Contains 1 topaquinone per subunit (By similarity)
Subunit: Forms a heterodimer with AOC3, in vitro
Secondary accessions: A5PKW2 O00120 O75105 Q4TTW5 Q9UNY0
Alternative splicing: 2 isoforms:  O75106-1   O75106-2   

Explore the universe of human proteins at neXtProt for AOC2: NX_O75106

Explore proteomics data for AOC2 at MOPED

Post-translational modifications: 

  • Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue1
  • Glycosylation2 at Asn133, Asn198, Asn226, Asn588, Asn662
  • Selected DME Specific Peptides for AOC2 (O75106) (see all 10)
     NYDYIWD  EELTAVM  PRYLYLA  SWGRYQL 


    See AOC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001149.2  NP_033720.2  

    ENSEMBL proteins: 
     ENSP00000253799   ENSP00000406134  

    AOC2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for AOC2
    OriGene Protein Over-expression Lysate for AOC2
    OriGene MassSpec for AOC2
    OriGene Custom Protein Services for AOC2
    GenScript Custom Purified and Recombinant Proteins Services for AOC2
    Novus Biologicals AOC2 Proteins
    Novus Biologicals AOC2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AOC2

     
    Search eBioscience for Proteins for AOC2 

    AOC2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AOC2
    Novus Biologicals AOC2 Antibodies
    Abcam antibodies for AOC2
    Cloud-Clone Corp. Antibodies for AOC2
    Search ThermoFisher Antibodies for AOC2
    LSBio Antibodies in human, mouse, rat for AOC2

    AOC2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AOC2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AOC2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AOC2
    Cloud-Clone Corp. CLIAs for AOC2
    Search eBioscience for ELISAs for AOC2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR015800 Cu_amine_oxidase_N2
     IPR016182 Cu_amine_oxidase_N-reg
     IPR015802 Cu_amine_oxidase_N3
     IPR015801 Cu_amine_oxidase_N2/3
     IPR000269 Cu_amine_oxidase

    Graphical View of Domain Structure for InterPro Entry O75106

    ProtoNet protein and cluster: O75106

    1 Blocks protein domain: IPB000269 Copper amine oxidase

    UniProtKB/Swiss-Prot: AOC2_HUMAN, O75106
    Similarity: Belongs to the copper/topaquinone oxidase family


    Find genes that share domains with AOC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AOC2_HUMAN, O75106
    Function: Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May
    play a role in adipogenesis. May be a critical modulator of signal transmission in retina
    Catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
    Biophysicochemical properties: Kinetic parameters: KM=0.056 mM for tryptamine; KM=0.077 mM for 2-phenylethylamine;
    KM=0.167 mM for benzylamine; KM=0.178 mM for p-tyramine; KM=1.7 mM for methylamine;
    Induction: Up-regulated during in vitro adipocyte differentiation

         Genatlas biochemistry entry for AOC2:
    amine oxidase,copper containing 2,retina specific,with two alternatively spliced isoforms

         Enzyme Numbers (IUBMB): EC 1.4.3.211 EC 1.4.32

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding IEA--
    GO:0008131primary amine oxidase activity IEA--
    GO:0009055electron carrier activity TAS9119395
    GO:0048038quinone binding IEA--
    GO:0052593tryptamine:oxygen oxidoreductase (deaminating) activity IEA--
         
    Find genes that share ontologies with AOC2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AOC2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AOC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AOC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AOC2

    miRNA
    Products:
        
    miRTarBase miRNAs that target AOC2:
    hsa-let-7a-5p (MIRT052452)

    Block miRNA regulation of human, mouse, rat AOC2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AOC2
    SwitchGear 3'UTR luciferase reporter plasmidAOC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AOC2
    Predesigned siRNA for gene silencing in human, mouse, rat AOC2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AOC2

    Clone
    Products:
         
    OriGene clones in human, mouse for AOC2 (see all 9)
    OriGene ORF clones in mouse, rat for AOC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AOC2 (NM_009590)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AOC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AOC2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AOC2
    Browse ESI BIO Cell Lines and PureStem Progenitors for AOC2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AOC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AOC2_HUMAN, O75106: Isoform 1: Cell membrane; Peripheral membrane protein. Note=Present on the surface of the
    cells
    AOC2_HUMAN, O75106: Isoform 2: Cytoplasm. Note=Either not translocated to the plasma membrane or below detection
    level
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    lysosome2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with AOC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AOC2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1beta-Alanine metabolism
    beta-Alanine metabolism
    phenylethylamine degradation I0.00
    2Phenylalanine metabolism
    Phenylalanine metabolism0.36
    Tyrosine metabolism0.36
    3Metabolism
    Metabolic pathways0.38
    4Tyrosine metabolism p.1 dopamine
    Tyrosine metabolism p.1 dopamine
    5histamine degradation
    histamine degradation


    Find genes that share SuperPaths with AOC2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for AOC2
        Tyrosine metabolism p.1 (dopamine)

    2 BioSystems Pathways for AOC2
        histamine degradation
    phenylethylamine degradation I


    5 Kegg Pathways  (Kegg details for AOC2):
        Glycine, serine and threonine metabolism
    Tyrosine metabolism
    Phenylalanine metabolism
    beta-Alanine metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AOC2
    Interactions:

        Search GeneGlobe Interaction Network for AOC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AOC2 (ENSP000002537994) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COMTENSP000003545114STRING: ENSP00000354511
    DBHENSP000003767764STRING: ENSP00000376776
    DDCENSP000003506164STRING: ENSP00000350616
    ALDH1A3ENSP000003322564STRING: ENSP00000332256
    ALDH1B1ENSP000003669274STRING: ENSP00000366927
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006584catecholamine metabolic process IEA--
    GO:0007601visual perception TAS9119395
    GO:0009308amine metabolic process IEA--
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with AOC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AOC2

    Selected HMDB Compounds for AOC2 (see all 21)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1,3-Diaminopropane1,3-Diamino-n-propane (see all 8)109-76-2--
    1-Phenylethylaminea-phenylethylamine (see all 17)98-84-0--
    3,4-DihydroxyphenylacetaldehydeProtocatechuatealdehyde (see all 2)5707-55-1--
    Aminoacetone1-Amino-2-propanone (see all 6)298-08-8--
    AmmoniaNH3 (see all 31)7664-41-7--
    Cadaverine1,5-Diaminopentane (see all 9)462-94-2--
    CalciumCa (see all 2)7440-70-2--
    CopperCu (see all 2)7440-50-8--
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--
    FormaldehydeAldeide formica (see all 16)50-00-0--

    1 Novoseek inferred chemical compound relationship for AOC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amine 52 6 14585497 (3)



    Find genes that share compounds with AOC2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AOC2 gene (2 alternative transcripts): 
    NM_001158.3  NM_009590.2  

    Unigene Cluster for AOC2:

    Amine oxidase, copper containing 2 (retina-specific)
    Hs.143102  [show with all ESTs]
    Unigene Representative Sequence: NM_009590
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253799(uc002ibu.3) ENST00000452774(uc002ibt.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AOC2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AOC2
    SwitchGear 3'UTR luciferase reporter plasmidAOC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AOC2
    Predesigned siRNA for gene silencing in human, mouse, rat AOC2
    Clone
    Products:
         
    OriGene clones in human, mouse for AOC2 (see all 9)
    OriGene ORF clones in mouse, rat for AOC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AOC2 (NM_009590)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AOC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AOC2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for AOC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AOC2
      QuantiTect SYBR Green Assays in human, mouse, rat AOC2
      QuantiFast Probe-based Assays in human, mouse, rat AOC2

    Additional mRNA sequence: 

    AF081363.1 BC142641.1 D88213.1 

    2 DOTS entries:

    DT.100740715  DT.100021332 

    20 AceView cDNA sequences:

    AF081363 CA397128 CA391266 CA389197 BM711998 NM_001158 CA393704 CA427935 
    N50959 CA425343 BM719996 CA395002 BQ002453 D88213 BX116991 NM_009590 
    BM675947 BF986543 BG108394 AW890286 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for AOC2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for AOC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AOC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCATTCAAA
    AOC2 Expression
    About this image


    AOC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocyte-like cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocyte-like cells
    AOC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AOC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143102

    UniProtKB/Swiss-Prot: AOC2_HUMAN, O75106
    Tissue specificity: Expressed in many tissues with much higher expression in retina. Isoform 1 and isoform 2 are
    expressed in adipose tissue, whereas isoform 1 only seems to be present in thymus, and isoform 2 only in testis

        Custom PCR Arrays for AOC2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for AOC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AOC2
    QuantiTect SYBR Green Assays in human, mouse, rat AOC2
    QuantiFast Probe-based Assays in human, mouse, rat AOC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AOC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for AOC2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aoc21 , 5 amine oxidase, copper containing 2 (retina-specific)1, 5 83.16(n)1
    80.95(a)1
      11 (64.70 cM)5
    2379401  NM_178932.11  NP_849263.11 
     1013250635 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Amine oxidase
    (see all 3)
    60(a)
    50(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    6(62395837-62405196)
    6(62355879-62372988)
    zebrafish
    (Danio rerio)
    Actinopterygii aoc26
    amine oxidase, copper containing 2
    42(a)
    1 → many
    3(33061161-33071335) ENSDARG00000014646


    ENSEMBL Gene Tree for AOC2 (if available)
    TreeFam Gene Tree for AOC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for AOC2 gene
    AOC12  AOC32  
    3 SIMAP similar genes for AOC2 using alignment to 1 protein entry:     AOC2_HUMAN:
    AOC3    ABP1    AOC1

    Find genes that share paralogs with AOC2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AOC2 (see all 200)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs44931151,2
    H--40996285(-) CCTCAG/TATGCC 2 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1460243811,2
    --40996341(+) GCATCA/GTTAAC 2 -- us2k10--------
    rs1398307751,2
    --40996366(+) ATCTGC/GTCTAA 2 -- us2k10--------
    rs1179428551,2
    F--40996368(+) CTGGTC/GTAAAT 2 -- us2k11Minor allele frequency- G:0.01EA 120
    rs352440311,2
    C--40996476(+) GGACAG/CAAAAT 2 -- us2k16Minor allele frequency- C:0.01NS EA 310
    rs169680381,2
    C,F,H--40996563(+) ATCCTA/GGCGAA 2 -- us2k128Minor allele frequency- G:0.06NA EA NS 2732
    rs1931245291,2
    --40996566(+) CTAGCA/GAATAT 2 -- us2k10--------
    rs1855500921,2
    --40996577(+) AAACCC/TCGACT 2 -- us2k10--------
    rs351544331,2
    C--40996617(+) TAGAAT/CTCTGA 2 -- ut516Minor allele frequency- C:0.04NS WA 308
    rs1420427481,2
    C,F--40996642(+) ATCCAC/ACATGC 2 -- ut512Minor allele frequency- A:0.00NA EU 5615

    HapMap Linkage Disequilibrium report for AOC2 (40996609 - 41002724 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AOC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv483009CNV Gain15286789
    esv33998OTHER Inversion15654335

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AOC2
    DNA2.0 Custom Variant and Variant Library Synthesis for AOC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602268    OMIM disorders: --

    1 disease for AOC2:    
    About MalaCards
    dissecting aortic aneurysm

    2 diseases from the University of Copenhagen DISEASES database for AOC2:
    Dissecting aortic aneurysm     Diabetes mellitus

    Find genes that share disorders with AOC2           About GenesLikeMe


    Export disorders for AOC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AOC2 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with AOC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human retina-specific amine oxidase: genomic structure of the gene (AOC2), alternatively spliced variant, and mRNA expression in retina. (PubMed id 9722954)1, 2, 3, 9 Imamura Y.... Shimizu N. (Genomics 1998)
    2. Human retina-specific amine oxidase (RAO): cDNA cloning, tissue expression, and chromosomal mapping. (PubMed id 9119395)1, 2, 3, 9 Imamura Y.... Shimizu N. (Genomics 1997)
    3. The unique substrate specificity of human AOC2, a semicarbazide- sensitive amine oxidase. (PubMed id 19588076)1, 2 Kaitaniemi S.... Elima K. (Cell. Mol. Life Sci. 2009)
    4. Characterization of AOC2 gene encoding a copper-binding amine oxidase expressed specifically in retina. (PubMed id 14585497)1, 9 Zhang Q.... Iwata T. (Gene 2003)
    5. Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes. (PubMed id 17400359)2 Bour S.... Carpene C. (Biochimie 2007)
    6. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    9. High expression of semicarbazide-sensitive amine oxidase genes AOC2 and AOC3, but not the diamine oxidase gene AOC1 in human adipocytes. (PubMed id 12755418)2 Heniquez A.... Carpene C. (Inflamm. Res. 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 314 HGNC: 549 AceView: AOC2 Ensembl:ENSG00000131480 euGenes: HUgn314
    ECgene: AOC2 Kegg: 314 H-InvDB: AOC2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AOC2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/aoc2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AOC2 gene:
    Search GeneIP for patents involving AOC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for AOC2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for AOC2  
     OriGene MassSpec something-or-other for AOC2   OriGene clones in human, mouse for AOC2  
     OriGene qSTAR qPCR primer pairs in human, mouse for AOC2   OriGene Purified Protein for AOC2  
     OriGene ORF clones in mouse, rat for AOC2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AOC2   OriGene Custom Protein Services for AOC2  

     
     
     Block miRNA regulation of human, mouse, rat AOC2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AOC2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AOC2 Predesigned siRNA for gene silencing in human, mouse, rat AOC2
     QuantiFast Probe-based Assays in human, mouse, rat AOC2 QuantiTect SYBR Green Assays in human, mouse, rat AOC2
     Custom PCR Arrays for AOC2 Search Chromatin IP Primers for AOC2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AOC2  Search GeneGlobe Interaction Network for AOC2
     Regulatory tfbs in AOC2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for AOC2 GenScript cDNA clones with any tag delivered in your preferred vector for AOC2
     GenScript Custom Assay Services for AOC2 GenScript Custom overexpressing Cell Line Services for AOC2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for AOC2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AOC2 antibodies
     AOC2 proteins
     AOC2 lysates
     Antibodies for AOC2
     See all of Abcam's Antibodies, Kits and Proteins for AOC2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for AOC2
     Antibodies for AOC2
     ELISAs for AOC2
     CLIAs for AOC2



     Browse ESI BIO Cell Lines and PureStem Progenitors for AOC2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AOC2
     SwitchGear 3'UTR luciferase reporter plasmids for AOC2
     SwitchGear Promoter luciferase reporter plasmids for AOC2
     Search ThermoFisher Antibodies for AOC2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AOC2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AOC2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AOC2
     LSBio Antibodies in human, mouse, rat for AOC2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for AOC2
      Search eBioscience for proteins for AOC2
      Search eBioscience for elisas for AOC2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AOC2 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4