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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AOC2 Gene

protein-coding GIFtS: 57
GCID: GC17P040996

amine oxidase, copper containing 2 (retina-specific)

Explore 3 diseases affiliated with
AOC2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Amine Oxidase, Copper Containing 2 (Retina-Specific)¹ ²		Retina-Specific Copper Amine Oxidase²
RAO¹ ² ³ ⁵		EC 1.4.3.21³
DAO2¹ ²		Amine Oxidase [Copper-Containing]³
Semicarbazide-Sensitive Amine Oxidase² ³		EC 1.4.3⁸
SSAO² ³

External Ids:	HGNC: 549¹	Entrez Gene: 314²	Ensembl: ENSG00000131480⁷	OMIM: 602268⁵	UniProtKB: O75106³

Export aliases for AOC2 gene to outside databases

Previous GC identifers: GC17M040628 GC17P043158 GC17P040905 GC17P041369 GC17P038250 GC17P036761

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AOC2:

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper

and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging

from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases

and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina,

possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for

hereditary ocular diseases. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AOC2_HUMAN, O75106

Function: Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a

role in adipogenesis. May be a critical modulator of signal transmission in retina

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AOC2 gene promoter:
p53 AP-1 ATF-2 NF-kappaB1 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AOC2 promoter sequence

Search SABiosciences Chromatin IP Primers for AOC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AOC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21

AOC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AOC2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P040996: view genomic region (about GC identifiers)

Start:	40,996,609 bp from pter	End:	41,002,724 bp from pter
Size:	6,116 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AOC2_HUMAN, O75106 (See protein sequence)

Recommended Name: Retina-specific copper amine oxidase precursor

Size: 756 amino acids; 83673 Da

Cofactor: Binds 1 copper ion per subunit (By similarity)

Cofactor: Binds 2 calcium ions per subunit (By similarity)

Cofactor: Contains 1 topaquinone per subunit (By similarity)

Subunit: Forms a heterodimer with AOC3, in vitro

Subcellular location: Isoform 1: Cell membrane; Peripheral membrane protein. Note=Present on the surface of the cells

Subcellular location: Isoform 2: Cytoplasm. Note=Either not translocated to the plasma membrane or below detection

level

Secondary accessions: A5PKW2 O00120 O75105 Q4TTW5 Q9UNY0

Alternative splicing: 2 isoforms: O75106-1 O75106-2

Explore the universe of human proteins at neXtProt for AOC2: NX_O75106

Post-translational modifications:

Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75106

4/10 DME Specific Peptides for AOC2 (O75106) (see all 10)

NYDYIWD

EELTAVM

PRYLYLA

SWGRYQL

AOC2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001149.2 NP_033720.2

ENSEMBL proteins:

ENSP00000253799 ENSP00000406134

Human Recombinant Protein Products for AOC2:

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	Uscn Proteins for AOC2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--

AOC2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AOC2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR015800 Cu_amine_oxidase_N2

IPR015802 Cu_amine_oxidase_N3

IPR016182 Cu_amine_oxidase_N-reg

IPR015801 Cu_amine_oxidase_N2/3

IPR000269 Cu_amine_oxidase

Graphical View of Domain Structure for InterPro Entry O75106

ProtoNet protein and cluster: O75106

1 Blocks protein family: IPB000269 Copper amine oxidase

UniProtKB/Swiss-Prot: AOC2_HUMAN, O75106

Similarity: Belongs to the copper/topaquinone oxidase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: AOC2_HUMAN, O75106

Function: Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a

role in adipogenesis. May be a critical modulator of signal transmission in retina

Catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)

Biophysicochemical properties: Kinetic parameters: KM=0.056 mM for tryptamine; KM=0.077 mM for 2-phenylethylamine;

KM=0.167 mM for benzylamine; KM=0.178 mM for p-tyramine; KM=1.7 mM for methylamine;

Induction: Up-regulated during in vitro adipocyte differentiation

Genatlas biochemistry entry for AOC2:

amine oxidase,copper containing 2,retina specific,with two alternatively spliced isoforms

Enzyme Numbers (IUBMB): EC 1.4.3.21¹ EC 1.4.3²

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005507	copper ion binding	IEA	--
GO:0008131	primary amine oxidase activity	IEA	--
GO:0009055	electron carrier activity	TAS	9119395
GO:0048038	quinone binding	IEA	--
GO:0052593	tryptamine:oxygen oxidoreductase (deaminating) activity	IEA	--

AOC2 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AOC2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Tyrosine metabolism

	Tyrosine metabolism	1.00			Tyrosine metabolism p.1 (dopamine)	0.28
	Phenylalanine metabolism	0.35			Tyrosine metabolism p.1 (dopamine)	0.28

phenylethylamine degradation I

phenylethylamine degradation I

1.00

histamine degradation

histamine degradation

1.00

beta-Alanine metabolism

beta-Alanine metabolism

1.00

Glycine, serine and threonine metabolism

Glycine, serine and threonine metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for AOC2

Tyrosine metabolism p.1 (dopamine)

1 GeneGo (Thomson Reuters) Pathway for AOC2

Tyrosine metabolism p.1 (dopamine)

2 BioSystems Pathways for AOC2

	histamine degradation
	phenylethylamine degradation I

5 Kegg Pathways (Kegg details for AOC2):

	Glycine, serine and threonine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	beta-Alanine metabolism
	Metabolic pathways

AOC2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AOC2

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/15 Interacting proteins for AOC2 (ENSP00000253799⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COMT	ENSP00000354511⁴	STRING: ENSP00000354511
DBH	ENSP00000376776⁴	STRING: ENSP00000376776
DDC	ENSP00000350616⁴	STRING: ENSP00000350616
ALDH1A3	ENSP00000332256⁴	STRING: ENSP00000332256
ALDH1B1	ENSP00000366927⁴	STRING: ENSP00000366927

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006584	catecholamine metabolic process	IEA	--
GO:0007601	visual perception	TAS	9119395
GO:0009308	amine metabolic process	IEA	--

AOC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AOC2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AOC2

10/21 HMDB Compounds for AOC2 (see all 21) About this table

Compound	Synonyms	CAS #	PubMed Ids
1,3-Diaminopropane	1,3-Diamino-n-propane (see all 8)	109-76-2	--
1-Phenylethylamine	a-phenylethylamine (see all 17)	98-84-0	--
3,4-Dihydroxyphenylacetaldehyde	Protocatechuatealdehyde (see all 2)	5707-55-1	--
Aminoacetone	1-Amino-2-propanone (see all 6)	298-08-8	--
Ammonia	NH3 (see all 31)	7664-41-7	--
Cadaverine	1,5-Diaminopentane (see all 9)	462-94-2	--
Calcium	Ca (see all 2)	7440-70-2	--
Copper	Cu (see all 2)	7440-50-8	--
Dopamine	2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)	62-31-7	--
Formaldehyde	Aldeide formica (see all 16)	50-00-0	--

1 Novoseek chemical compound relationship for AOC2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
amine	52	6	14585497 (3)

Search CenterWatch for drugs/clinical trials and news about AOC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AOC2 gene (2 alternative transcripts):

NM_001158.3 NM_009590.2

Unigene Cluster for AOC2:

Amine oxidase, copper containing 2 (retina-specific)

Hs.143102 [show with all ESTs]

Unigene Representative Sequence: NM_009590

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000253799(uc002ibu.3) ENST00000452774(uc002ibt.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AOC2
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Additional cDNA sequence:

AF081363.1 BC142641.1 D88213.1

2 DOTS entries:

DT.100740715 DT.100021332

20 AceView cDNA sequences:

CA397128 CA391266 CA389197 BM711998 AF081363 BQ002453 CA395002 BM719996

CA425343 N50959 CA393704 NM_001158 D88213 BM675947 NM_009590 CA427935

BX116991 BF986543 BG108394 AW890286

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for AOC2 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4
SP1:					-
SP2:

ECgene alternative splicing isoforms for AOC2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AOC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCATTCAAA

About this image

AOC2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AOC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AOC2

SOURCE GeneReport for Unigene cluster: Hs.143102

UniProtKB/Swiss-Prot: AOC2_HUMAN, O75106

Tissue specificity: Expressed in many tissues with much higher expression in retina. Isoform 1 and isoform 2 are

expressed in adipose tissue, whereas isoform 1 only seems to be present in thymus, and isoform 2 only in testis

SABiosciences Custom PCR Arrays for AOC2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for AOC2 gene from 6/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PSME3_CHICK⁶	Proteasome activator complex subunit 3	25(a)	possible ortholog	27(4698615-4725288)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	60(a) 50(a) (see all 3)	possible ortholog many ↔ many (see all 3)	6(62395990-62400644) 6(62355879-62372988)
zebrafish (Danio rerio)	Actinopterygii	zgc:113006⁶	zgc:113006	45(a)	1 → many	3(33061160-33071335)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G12280⁶ ATAO1⁶ (see all 10)	amine oxidase 1 (see all 10)	24(a) 22(a) (see all 10)	many ↔ many many ↔ many (see all 10)	4(7301769-7302994) 4(8541879-8544566)
rice (Oryza sativa)	Liliopsida	-- -- (see all 6)	amine oxidase precursor, putative, expressed copper methylamine oxidase precursor, putative, ex... (see all 6)	22(a) 19(a) (see all 6)	many ↔ many many ↔ many (see all 6)	4(11227167-11234756) 6(13475488-13484210)
E. coli (Escherichia coli)	Gamma proteobacteria	tynA⁶	tyramine oxidase, copper-requiring	18(a)	1 → many	Chromosome(1447100-1449373)

ENSEMBL Gene Tree for AOC2 (if available)
TreeFam Gene Tree for AOC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AOC2 gene

ABP1² AOC3²

2 SIMAP similar genes for AOC2 using alignment to 1 protein entry: AOC2_HUMAN:

AOC3 ABP1

AOC2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191910662^1,2		--	40994709(+)	`CACATG/TTGTGT`	6	--	us2k¹ nc-transcript-variantut3¹		0	--	--	--	--
rs115860809^1,2	C,F	--	40994955(+)	`CCACCG/AGGGAT`	6	--	us2k¹ ut3¹ nc-transcript-variant		1		WA	118
rs182960547^1,2		--	40995083(+)	`CAGATC/TCCTTC`	6	--	us2k¹ ut3¹ nc-transcript-variant		0	--	--	--	--
rs34878294^1,2	C	--	40995121(+)	`ATGTGT/CTTCTC`	6	--	nc-transcript-variantut3¹ us2k¹		7		NS NA	194
rs186029887^1,2		--	40995217(+)	`CATGTC/GAAGAA`	6	--	ut3¹ nc-transcript-variantus2k¹		0	--	--	--	--
rs35756762^1,2	C	--	40995283(+)	`ATGCTC/G/TTGGTG`	10	--	us2k¹ ut3¹ nc-transcript-variant		5		NS	190
rs35704777^1,2	C,F	--	40995286(+)	`CTCTGG/ATGGCT`	6	--	nc-transcript-variantut3¹ us2k¹		5		NS	190
rs139296430^1,2		--	40995474(+)	`TTATGA/GGAAAG`	6	--	ut3¹ nc-transcript-variantus2k¹		0	--	--	--	--
rs186987705^1,2		--	40995643(+)	`TTTACC/TTTATA`	6	--	us2k¹ ut3¹ nc-transcript-variant		0	--	--	--	--
rs35759054^1,2	C,F,H	--	40995648(+)	`CTTATA/GCTAAT`	6	--	us2k¹ nc-transcript-variantut3¹		12		NS NA WA	1102

HapMap Linkage Disequilibrium report for AOC2 (40996609 - 41002724 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AOC2
1 CNV: 0206

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AOC2 for disorders           About GeneDecksing

OMIM gene information: 602268    OMIM disorders: --

3 diseases for AOC2:    About MalaCards

dissecting aortic aneurysm aortic aneurysm chorioretinitis

2 diseases from the University of Copenhagen DISEASES database for AOC2:

Dissecting aortic aneurysm Diabetes mellitus

Export disorders for AOC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for AOC2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with AOC2)

Utopia: connect your pdf to the dynamic
world of online information

Human retina-specific amine oxidase: genomic structure of the gene (AOC2), alternatively spliced variant, and mRNA expression in retina. (PubMed id 9722954)^{1, 2, 3, 9} Imamura Y.... Shimizu N. (1998)
Human retina-specific amine oxidase (RAO): cDNA cloning, tissue expression, and chromosomal mapping. (PubMed id 9119395)^{1, 2, 3, 9} Imamura Y.... Shimizu N. (1997)
The unique substrate specificity of human AOC2, a semicarbazide- sensitive amine oxidase. (PubMed id 19588076)^{1, 2} Kaitaniemi S.... Elima K. (2009)
Characterization of AOC2 gene encoding a copper-binding amine oxidase expressed specifically in retina. (PubMed id 14585497)^{1, 9} Zhang Q.... Iwata T. (2003)
Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes. (PubMed id 17400359)² Bour S.... Carpene C. (2007)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)² Zody M.C.... Nusbaum C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)
High expression of semicarbazide-sensitive amine oxidase genes AOC2 and AOC3, but not the diamine oxidase gene AOC1 in human adipocytes. (PubMed id 12755418)² Heniquez A.... Carpene C. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 314	HGNC: 549	AceView: AOC2	Ensembl:ENSG00000131480	euGenes: HUgn314
ECgene: AOC2	Kegg: 314	H-InvDB: AOC2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for AOC2	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/aoc2/

Intellectual Property for AOC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for AOC2 gene:
Search GeneIP for patents involving AOC2

GeneCards and IP:
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amine oxidase, copper containing 2 (retina-specific)

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amine oxidase, copper containing 2 (retina-specific)

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