Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AOAH Gene

protein-coding   GIFtS: 56
GCID: GC07M036519

Acyloxyacyl Hydrolase (Neutrophil)

  Search for AOAH
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Acyloxyacyl Hydrolase (Neutrophil)1 2
Acyloxyacyl Hydrolase2
EC 3.1.1.773

External Ids:    HGNC: 5481   Entrez Gene: 3132   Ensembl: ENSG000001362507   OMIM: 1025935   UniProtKB: P280393   

Export aliases for AOAH gene to outside databases

Previous GC identifers: GC07M036199 GC07M036293 GC07M036325


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for AOAH Gene:
This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the
hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying
these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative
bacteria. Alternatively spliced transcript variants have been described.(provided by RefSeq, Apr 2010)

GeneCards Summary for AOAH Gene:
AOAH (acyloxyacyl hydrolase (neutrophil)) is a protein-coding gene. GO annotations related to this gene include lipoprotein lipase activity and acyloxyacyl hydrolase activity.

UniProtKB/Swiss-Prot: AOAH_HUMAN, P28039
Function: Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial
lipopolysaccharides

Gene Wiki entry for AOAH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the AOAH gene promoter:
         COUP-TF1   oct-B3   oct-B2   COUP   HNF-4alpha2   POU2F2   HNF-4alpha1   COUP-TF   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AOAH promoter sequence
   Search Chromatin IP Primers for AOAH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AOAH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14-p12   Ensembl cytogenetic band:  7p14.2   HGNC cytogenetic band: 7p14-p12

AOAH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AOAH gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M036519:  view genomic region     (about GC identifiers)

Start:
36,552,456 bp from pter      End:
36,764,154 bp from pter
Size:
211,699 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 36,590,357-36,801,982     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AOAH_HUMAN, P28039 (See protein sequence)
Recommended Name: Acyloxyacyl hydrolase precursor  
Size: 575 amino acids; 65105 Da
Subunit: Heterodimer
Secondary accessions: A4D1Y5 B7Z490 Q53F13
Alternative splicing: 2 isoforms:  P28039-1   P28039-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AOAH: NX_P28039

Explore proteomics data for AOAH at MOPED

Post-translational modifications: 

  • Both subunits contain a number of cysteine residues that may form disulfide bridges1
  • Glycosylation2 at Asn59, Asn207, Asn336, Asn409, Asn466
  • Modification sites at PhosphoSitePlus

  • See AOAH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001170977.1  NP_001170978.1  NP_001628.1  

    ENSEMBL proteins: 
     ENSP00000258749   ENSP00000405683   ENSP00000416051   ENSP00000416472   ENSP00000441101  
     ENSP00000439283  

    AOAH Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for AOAH
    OriGene Protein Over-expression Lysate for AOAH
    OriGene MassSpec for AOAH
    OriGene Custom Protein Services for AOAH
    GenScript Custom Purified and Recombinant Proteins Services for AOAH
    Novus Biologicals AOAH Proteins
    Novus Biologicals AOAH Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AOAH

     
    Search eBioscience for Proteins for AOAH 

    AOAH Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for AOAH
    OriGene Custom Antibody Services for AOAH
    Novus Biologicals AOAH Antibodies
    Abcam antibodies for AOAH
    Cloud-Clone Corp. Antibodies for AOAH
    Search ThermoFisher Antibodies for AOAH
    LSBio Antibodies in human, mouse, rat for AOAH

    AOAH Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AOAH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AOAH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AOAH
    Cloud-Clone Corp. CLIAs for AOAH
    Search eBioscience for ELISAs for AOAH 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR008138 SapB_2
     IPR011001 Saposin-like
     IPR013831 SGNH_hydro-type_esterase_dom
     IPR008139 SaposinB
     IPR001087 Lipase_GDSL

    Graphical View of Domain Structure for InterPro Entry P28039

    ProtoNet protein and cluster: P28039

    2 Blocks protein domains:
    IPB001087 Lipolytic enzyme
    IPB008139 Saposin B


    UniProtKB/Swiss-Prot: AOAH_HUMAN, P28039
    Similarity: Contains 1 saposin B-type domain


    Find genes that share domains with AOAH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AOAH_HUMAN, P28039
    Function: Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial
    lipopolysaccharides
    Catalytic activity: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty
    acid

         Genatlas biochemistry entry for AOAH:
    acyloxyacyl hydrolase,two-subunit lipase expressed in phagocytic cells,specifically hydrolyzing the secondary acyl
    chains of the liposaccharide found in the walls of gram-negative bacteria

         Enzyme Number (IUBMB): EC 3.1.1.771

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS1883828
    GO:0004465lipoprotein lipase activity TAS1883828
    GO:0016788hydrolase activity, acting on ester bonds ----
    GO:0050528acyloxyacyl hydrolase activity IEA--
         
    Find genes that share ontologies with AOAH           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Aoah):
     immune system 

    Find genes that share phenotypes with AOAH           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Aoahtm1Rsm for AOAH

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AOAH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AOAH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AOAH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AOAH

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat AOAH using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate AOAH:
    hsa-miR-3673
    SwitchGear 3'UTR luciferase reporter plasmidAOAH 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AOAH
    Predesigned siRNA for gene silencing in human, mouse, rat AOAH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AOAH

    Clone
    Products:
         
    OriGene clones in human, mouse for AOAH (see all 15)
    OriGene ORF clones in mouse, rat for AOAH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): AOAH (NM_001637)
    Sino Biological Human cDNA Clone for AOAH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AOAH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AOAH

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AOAH
    Browse ESI BIO Cell Lines and PureStem Progenitors for AOAH 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AOAH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AOAH_HUMAN, P28039: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with AOAH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AOAH
    Interactions:

        Search GeneGlobe Interaction Network for AOAH

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for AOAH (P280393 ENSP000002587494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGHG1P018573, ENSP000003749904I2D: score=1 STRING: ENSP00000374990
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS1883828
    GO:0006954inflammatory response TAS1883828
    GO:0008653lipopolysaccharide metabolic process IEA--
    GO:0050728negative regulation of inflammatory response IEA--

    Find genes that share ontologies with AOAH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AOAH

    1 HMDB Compound for AOAH    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 Novoseek inferred chemical compound relationship for AOAH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endotoxin 38.8 2 1987068 (2)



    Find genes that share compounds with AOAH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AOAH gene (3 alternative transcripts): 
    NM_001177506.1  NM_001177507.1  NM_001637.3  

    Unigene Cluster for AOAH:

    Acyloxyacyl hydrolase (neutrophil)
    Hs.488007  [show with all ESTs]
    Unigene Representative Sequence: NM_001177506
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258749(uc003tfh.4) ENST00000471806 ENST00000431169(uc022abu.1)
    ENST00000483864 ENST00000491444 ENST00000487014 ENST00000495942 ENST00000480201
    ENST00000543742 ENST00000435386 ENST00000414637 ENST00000535891(uc011kba.2)
    ENST00000538464
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AOAH using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate AOAH:
    hsa-miR-3673
    SwitchGear 3'UTR luciferase reporter plasmidAOAH 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AOAH
    Predesigned siRNA for gene silencing in human, mouse, rat AOAH
    Clone
    Products:
         
    OriGene clones in human, mouse for AOAH (see all 15)
    OriGene ORF clones in mouse, rat for AOAH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): AOAH (NM_001637)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AOAH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AOAH
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AOAH
    OriGene qSTAR qPCR primer pairs in human, mouse for AOAH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AOAH
      QuantiTect SYBR Green Assays in human, mouse, rat AOAH
      QuantiFast Probe-based Assays in human, mouse, rat AOAH

    Additional mRNA sequence: 

    AK223476.1 AK297016.1 AK298644.1 AK308215.1 BC025698.1 M62840.1 

    9 DOTS entries:

    DT.95161135  DT.121109380  DT.75126381  DT.92069026  DT.121109408  DT.213179  DT.40117223  DT.40117351 
    DT.91664621 

    Selected AceView cDNA sequences (see all 51):

    AW969571 BI768131 NM_001637 AI423020 N50131 BQ448512 M62840 AA524159 
    AI356011 BC025698 BG685317 AI338008 AI825625 AI633804 CB046662 AA311288 
    BM925048 AA131061 AA493386 AI632563 BI838865 CD368011 AI935091 AI082606 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AOAH    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b
    SP1:                                                                    -     -     -                                                     -                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            


    ECgene alternative splicing isoforms for AOAH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AOAH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCCCTGGG
    AOAH Expression
    About this image


    AOAH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Spleen (Hematopoietic System)
    AOAH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AOAH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.488007
        Custom PCR Arrays for AOAH
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AOAH
    OriGene qSTAR qPCR primer pairs in human, mouse for AOAH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AOAH
    QuantiTect SYBR Green Assays in human, mouse, rat AOAH
    QuantiFast Probe-based Assays in human, mouse, rat AOAH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AOAH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for AOAH gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aoah1 , 5 acyloxyacyl hydrolase1, 5 81.3(n)1
    76.13(a)1
      13 (7.49 cM)5
    270521  NM_012054.41  NP_036184.11 
     207941195 
    chicken
    (Gallus gallus)
    Aves AOAH1 acyloxyacyl hydrolase (neutrophil) 68.09(n)
    63.82(a)
      420737  XM_004939531.1  XP_004939588.1 
    lizard
    (Anolis carolinensis)
    Reptilia AOAH6
    acyloxyacyl hydrolase (neutrophil)
    62(a)
    1 ↔ 1
    6(47002640-47088872)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia aoah1 acyloxyacyl hydrolase (neutrophil) 59.84(n)
    55.12(a)
      100491792  XM_002939415.2  XP_002939461.2 


    ENSEMBL Gene Tree for AOAH (if available)
    TreeFam Gene Tree for AOAH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AOAH (see all 4588)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs351532581,2
    C--36434901(+) CACAG-/CA/GA 
            
    AAAGT
    3 -- int10--------
    rs801683671,2
    F--36524592(+) TCAAAT/GTATTT 3 -- ds50011Minor allele frequency- G:0.02WA 118
    rs789233101,2
    F--36524708(+) TTATAC/GCCACT 3 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1426878531,2
    --36524755(+) TATTGC/TCATTT 3 -- ds50010--------
    rs598945321,2
    C,F--36524935(+) TGTGTG/AAGTCC 3 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1386253691,2
    C--36525015(+) CACAGC/GGGGGA 3 -- ds50010--------
    rs32097241,2
    C--36525134(-) CCAAAC/AAAAAG 3 -- ut312Minor allele frequency- A:0.00NA 4
    rs755318451,2
    C,F--36525142(+) TGGAAT/CGGCAC 3 -- ut311Minor allele frequency- C:0.03WA 118
    rs79861,2
    C,F,O,H--36525184(-) CCTTCC/TGCTGT 4 P L ut31 mis1 ese334Minor allele frequency- T:0.18MN EA NA NS WA 5259
    rs1160368051,2
    F--36525223(+) GCACAG/TTCGTC 4 N T ut31 mis11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for AOAH (36552456 - 36764154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for AOAH:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676624CNV Deletion23128226
    esv2613811CNV Deletion19546169
    nsv5700CNV Insertion18451855
    nsv470199CNV Loss18288195
    nsv464427CNV Loss19166990
    nsv830960CNV Loss17160897
    nsv366801CNV Loss16902084
    nsv830957CNV Gain17160897
    esv33783CNV Gain17666407
    nsv830958CNV Gain17160897

    Human Gene Mutation Database (HGMD): AOAH
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing AOAH:
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing AOAH
    DNA2.0 Custom Variant and Variant Library Synthesis for AOAH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 102593    OMIM disorders: --


    Find genes that share disorders with AOAH           About GenesLikeMe

    Genetic Association Database (GAD): AOAH
    Human Genome Epidemiology (HuGE) Navigator: AOAH (3 documents)

    Export disorders for AOAH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AOAH gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with AOAH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides. (PubMed id 1883828)1, 2, 3, 9 Hagen F.S.... Munford R.S. (Biochemistry 1991)
    2. Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes. (PubMed id 16815140)1, 4, 9 Barnes K.C....Mathias R.A. (J. Allergy Clin. Immunol. 2006)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Host determinants of HIV-1 control in African Americans. (PubMed id 20205591)1, 4 Pelak K.... . (J. Infect. Dis. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Adenovirus-mediated transfer of a gene encoding acyloxyacyl hydrolase (AOAH) into mice increases tissue and plasma AOAH activity. (PubMed id 8613354)1, 9 Coulthard M.G....Meidell R.S. (Infect. Immun. 1996)
    7. Intracellular and extracellular enzymatic deacylation of bacterial endotoxin during localized inflammation induced by Escherichia coli. (PubMed id 1987068)1, 9 McDermott C.M....Fenwick B.W. (Infect. Immun. 1991)
    8. Chromosomal localization of the acyloxyacyl hydrolase (AOAH) gene to 7p14-p12 using fluorescence in situ hybridization. (PubMed id 8088847)1, 9 Whitmore T.E....Durnam D.M. (Genomics 1994)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    10. Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study. (PubMed id 22723975)1 Zhang Y....Zhang L. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 313 HGNC: 548 AceView: AOAH Ensembl:ENSG00000136250 euGenes: HUgn313
    ECgene: AOAH H-InvDB: AOAH

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AOAH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AOAH gene:
    Search GeneIP for patents involving AOAH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AOAH   OriGene RNAi products in human, mouse, rat for AOAH  
     OriGene qPCR primer pairs and template standards for AOAH   OriGene Protein Over-expression Lysate for AOAH  
     OriGene MassSpec something-or-other for AOAH   OriGene clones in human, mouse for AOAH  
     OriGene qSTAR qPCR primer pairs in human, mouse for AOAH   OriGene Purified Protein for AOAH  
     OriGene ORF clones in mouse, rat for AOAH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AOAH   OriGene Custom Protein Services for AOAH  

     
     
     Block miRNA regulation of human, mouse, rat AOAH using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AOAH
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AOAH Predesigned siRNA for gene silencing in human, mouse, rat AOAH
     QuantiFast Probe-based Assays in human, mouse, rat AOAH QuantiTect SYBR Green Assays in human, mouse, rat AOAH
     Custom PCR Arrays for AOAH Search Chromatin IP Primers for AOAH
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AOAH  Search GeneGlobe Interaction Network for AOAH
     Regulatory tfbs in AOAH promoter
     GenScript Custom Purified and Recombinant Proteins Services for AOAH GenScript cDNA clones with any tag delivered in your preferred vector for AOAH
     GenScript Custom Assay Services for AOAH GenScript Custom overexpressing Cell Line Services for AOAH
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for AOAH
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for AOAH
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AOAH antibodies
     AOAH proteins
     AOAH lysates
     Antibodies for AOAH
     See all of Abcam's Antibodies, Kits and Proteins for AOAH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for AOAH
     Antibodies for AOAH
     ELISAs for AOAH
     CLIAs for AOAH



     Browse ESI BIO Cell Lines and PureStem Progenitors for AOAH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AOAH
     SwitchGear 3'UTR luciferase reporter plasmids for AOAH
     SwitchGear Promoter luciferase reporter plasmids for AOAH
     Search ThermoFisher Antibodies for AOAH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AOAH
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AOAH
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AOAH
     LSBio Antibodies in human, mouse, rat for AOAH
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for AOAH
      Search eBioscience for proteins for AOAH
      Search eBioscience for elisas for AOAH
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AOAH gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4