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Aliases for ANXA9 Gene

Aliases for ANXA9 Gene

  • Annexin A9 2 3 5
  • Annexin XXXI 3 4
  • Annexin-31 3 4
  • Annexin-9 3 4
  • Pemphaxin 3 4
  • ANX31 3 4
  • Annexin 31 3

External Ids for ANXA9 Gene

Previous HGNC Symbols for ANXA9 Gene

  • ANX31

Previous GeneCards Identifiers for ANXA9 Gene

  • GC01P148796
  • GC01P146701
  • GC01P147729
  • GC01P148171
  • GC01P147767
  • GC01P149221
  • GC01P122331

Summaries for ANXA9 Gene

Entrez Gene Summary for ANXA9 Gene

  • The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA9 Gene

ANXA9 (Annexin A9) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and phospholipid binding. An important paralog of this gene is ANXA4.

UniProtKB/Swiss-Prot for ANXA9 Gene

  • Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.

Gene Wiki entry for ANXA9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA9 Gene

Genomics for ANXA9 Gene

Regulatory Elements for ANXA9 Gene

Enhancers for ANXA9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANXA9 on UCSC Golden Path with GeneCards custom track

Promoters for ANXA9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANXA9 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANXA9 Gene

150,982,017 bp from pter
150,996,063 bp from pter
14,047 bases
Plus strand

Genomic View for ANXA9 Gene

Genes around ANXA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA9 Gene

Proteins for ANXA9 Gene

  • Protein details for ANXA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin A9
    Protein Accession:
    Secondary Accessions:
    • Q5SZF1
    • Q6FI55
    • Q9BS00
    • Q9HBJ6

    Protein attributes for ANXA9 Gene

    345 amino acids
    Molecular mass:
    38364 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=AAH05830.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA08933.1; Type=Frameshift; Positions=7; Evidence={ECO:0000305};

neXtProt entry for ANXA9 Gene

Proteomics data for ANXA9 Gene at MOPED

Post-translational modifications for ANXA9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANXA9 Gene

Domains & Families for ANXA9 Gene

Gene Families for ANXA9 Gene

Protein Domains for ANXA9 Gene

Suggested Antigen Peptide Sequences for ANXA9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA9: view

Function for ANXA9 Gene

Molecular function for ANXA9 Gene

GENATLAS Biochemistry:
annexin A9,mainly expressed in undifferentiating tissues,homolog of annexin 2 and derived by duplication of annexin 1
UniProtKB/Swiss-Prot Function:
Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.

Gene Ontology (GO) - Molecular Function for ANXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 22841549
GO:0005543 phospholipid binding IDA 10899159
GO:0042803 protein homodimerization activity TAS 10899159
genes like me logo Genes that share ontologies with ANXA9: view
genes like me logo Genes that share phenotypes with ANXA9: view

Animal Models for ANXA9 Gene

MGI Knock Outs for ANXA9:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ANXA9 Gene

Localization for ANXA9 Gene

Subcellular locations from

Jensen Localization Image for ANXA9 Gene COMPARTMENTS Subcellular localization image for ANXA9 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANXA9 Gene

Pathways & Interactions for ANXA9 Gene

SuperPathways for ANXA9 Gene

No Data Available

Interacting Proteins for ANXA9 Gene

Gene Ontology (GO) - Biological Process for ANXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IDA 10899159
GO:0007268 synaptic transmission IDA 10899159
genes like me logo Genes that share ontologies with ANXA9: view

No data available for Pathways by source and SIGNOR curated interactions for ANXA9 Gene

Drugs & Compounds for ANXA9 Gene

(1) Drugs for ANXA9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(124) Additional Compounds for ANXA9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with ANXA9: view

Transcripts for ANXA9 Gene

mRNA/cDNA for ANXA9 Gene

Unigene Clusters for ANXA9 Gene

Annexin A9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP3: -

Relevant External Links for ANXA9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA9 Gene

mRNA expression in normal human tissues for ANXA9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA9 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.4), Pancreas (x4.6), Liver (x4.3), and Skin - Not Sun Exposed (Suprapubic) (x4.2).

Protein differential expression in normal tissues from HIPED for ANXA9 Gene

This gene is overexpressed in Cervix (50.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ANXA9 Gene

SOURCE GeneReport for Unigene cluster for ANXA9 Gene Hs.3346

mRNA Expression by UniProt/SwissProt for ANXA9 Gene

Tissue specificity: Expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level).
genes like me logo Genes that share expression patterns with ANXA9: view

Primer Products

No data available for Protein tissue co-expression partners for ANXA9 Gene

Orthologs for ANXA9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANXA9 35
  • 85.22 (n)
  • 83.19 (a)
ANXA9 36
  • 83 (a)
(Canis familiaris)
Mammalia ANXA9 35
  • 87.44 (n)
  • 83.19 (a)
ANXA9 36
  • 82 (a)
(Mus musculus)
Mammalia Anxa9 35
  • 79.61 (n)
  • 77.68 (a)
Anxa9 16
Anxa9 36
  • 78 (a)
(Pan troglodytes)
Mammalia ANXA9 35
  • 99.81 (n)
  • 99.71 (a)
ANXA9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Anxa9 35
  • 81.3 (n)
  • 78.2 (a)
(Monodelphis domestica)
Mammalia ANXA9 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa9 35
  • 56.26 (n)
  • 47.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia anxa9-prov 35
(Danio rerio)
Actinopterygii ANXA9 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea nex-1 36
  • 26 (a)
nex-3 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for ANXA9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA9 Gene

Gene Tree for ANXA9 (if available)
Gene Tree for ANXA9 (if available)

Paralogs for ANXA9 Gene

(15) SIMAP similar genes for ANXA9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANXA9: view

Variants for ANXA9 Gene

Sequence variations from dbSNP and Humsavar for ANXA9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs267733 - 150,986,360(+) GGATG(A/G)CATCA reference, missense
rs7542365 -, - 150,987,954(+) CATCC(A/G)AGGTA reference, missense
VAR_048255 -
rs7536645 - 150,984,353(+) AGCCC(A/G)CAGCC reference, missense
rs16832602 - 150,984,368(+) TTGAC(A/G)CCCAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ANXA9 Gene

Variant ID Type Subtype PubMed ID
nsv522317 CNV Loss 19592680
nsv522840 CNV Gain 19592680

Variation tolerance for ANXA9 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ANXA9 Gene

Disorders for ANXA9 Gene

Relevant External Links for ANXA9

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANXA9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA9 Gene

Publications for ANXA9 Gene

  1. Expression profile and structural divergence of novel human annexin 31. (PMID: 9742942) Morgan R.O. … Fernandez M.-P. (FEBS Lett. 1998) 2 3 4 23 67
  2. Human annexin 31 genetic mapping and origin. (PMID: 9931420) Morgan R.O. … Fernandez M.P. (Gene 1999) 2 3 23
  3. Atypical properties displayed by annexin A9, a novel member of the annexin family of Ca(2+) and lipid binding proteins. (PMID: 12832069) Goebeler V. … Rescher U. (FEBS Lett. 2003) 3 23
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment. (PMID: 23585552) Kirin M. … Mitry D. (Hum. Mol. Genet. 2013) 3

Products for ANXA9 Gene

Sources for ANXA9 Gene