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Aliases for ANXA9 Gene

Aliases for ANXA9 Gene

  • Annexin A9 2 3
  • Annexin XXXI 3 4
  • Annexin-31 3 4
  • Annexin-9 3 4
  • Pemphaxin 3 4
  • ANX31 3 4
  • Annexin 31 3

External Ids for ANXA9 Gene

Previous HGNC Symbols for ANXA9 Gene

  • ANX31

Previous GeneCards Identifiers for ANXA9 Gene

  • GC01P148796
  • GC01P146701
  • GC01P147729
  • GC01P148171
  • GC01P147767
  • GC01P149221
  • GC01P122331

Summaries for ANXA9 Gene

Entrez Gene Summary for ANXA9 Gene

  • The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA9 Gene

ANXA9 (Annexin A9) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and phospholipid binding. An important paralog of this gene is ANXA4.

UniProtKB/Swiss-Prot for ANXA9 Gene

  • Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.

Gene Wiki entry for ANXA9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA9 Gene

Genomics for ANXA9 Gene

Regulatory Elements for ANXA9 Gene

Genomic Location for ANXA9 Gene

Chromosome:
1
Start:
150,982,017 bp from pter
End:
150,996,063 bp from pter
Size:
14,047 bases
Orientation:
Plus strand

Genomic View for ANXA9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANXA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA9 Gene

Proteins for ANXA9 Gene

  • Protein details for ANXA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76027-ANXA9_HUMAN
    Recommended name:
    Annexin A9
    Protein Accession:
    O76027
    Secondary Accessions:
    • Q5SZF1
    • Q6FI55
    • Q9BS00
    • Q9HBJ6

    Protein attributes for ANXA9 Gene

    Size:
    345 amino acids
    Molecular mass:
    38364 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH05830.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA08933.1; Type=Frameshift; Positions=7; Evidence={ECO:0000305};

neXtProt entry for ANXA9 Gene

Proteomics data for ANXA9 Gene at MOPED

Post-translational modifications for ANXA9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANXA9 Gene

Domains & Families for ANXA9 Gene

Gene Families for ANXA9 Gene

Protein Domains for ANXA9 Gene

Suggested Antigen Peptide Sequences for ANXA9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76027

UniProtKB/Swiss-Prot:

ANXA9_HUMAN :
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
Family:
  • Belongs to the annexin family.
Similarity:
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA9: view

Function for ANXA9 Gene

Molecular function for ANXA9 Gene

GENATLAS Biochemistry:
annexin A9,mainly expressed in undifferentiating tissues,homolog of annexin 2 and derived by duplication of annexin 1
UniProtKB/Swiss-Prot Function:
Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.

Gene Ontology (GO) - Molecular Function for ANXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 12832069
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 22841549
GO:0005543 phospholipid binding IDA 10899159
GO:0005544 calcium-dependent phospholipid binding IEA --
genes like me logo Genes that share ontologies with ANXA9: view

Phenotypes for ANXA9 Gene

genes like me logo Genes that share phenotypes with ANXA9: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANXA9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANXA9 Gene

Localization for ANXA9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA9 Gene COMPARTMENTS Subcellular localization image for ANXA9 gene
Compartment Confidence
cytosol 5
extracellular 5

Gene Ontology (GO) - Cellular Components for ANXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 12832069
GO:0009986 cell surface IDA 10899159
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ANXA9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA9 Gene

Pathways & Interactions for ANXA9 Gene

SuperPathways for ANXA9 Gene

No Data Available

Interacting Proteins for ANXA9 Gene

Gene Ontology (GO) - Biological Process for ANXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission IDA 10899159
GO:0016337 single organismal cell-cell adhesion IDA 10899159
genes like me logo Genes that share ontologies with ANXA9: view

No data available for Pathways by source and SIGNOR curated interactions for ANXA9 Gene

Drugs & Compounds for ANXA9 Gene

(1) Drugs for ANXA9 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetylcholine Experimental Pharma Full agonist, Agonist 104

(124) Additional Compounds for ANXA9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with ANXA9: view

Transcripts for ANXA9 Gene

mRNA/cDNA for ANXA9 Gene

Unigene Clusters for ANXA9 Gene

Annexin A9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANXA9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2:
SP3: -

Relevant External Links for ANXA9 Gene

GeneLoc Exon Structure for
ANXA9
ECgene alternative splicing isoforms for
ANXA9

Expression for ANXA9 Gene

mRNA expression in normal human tissues for ANXA9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA9 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.4), Pancreas (x4.6), Liver (x4.3), and Skin - Not Sun Exposed (Suprapubic) (x4.2).

Protein differential expression in normal tissues from HIPED for ANXA9 Gene

This gene is overexpressed in Cervix (50.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ANXA9 Gene



SOURCE GeneReport for Unigene cluster for ANXA9 Gene Hs.3346

mRNA Expression by UniProt/SwissProt for ANXA9 Gene

O76027-ANXA9_HUMAN
Tissue specificity: Expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level).
genes like me logo Genes that share expression patterns with ANXA9: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ANXA9 Gene

Orthologs for ANXA9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANXA9 35
  • 85.22 (n)
  • 83.19 (a)
ANXA9 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA9 35
  • 87.44 (n)
  • 83.19 (a)
ANXA9 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa9 35
  • 79.61 (n)
  • 77.68 (a)
Anxa9 16
Anxa9 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANXA9 35
  • 99.81 (n)
  • 99.71 (a)
ANXA9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa9 35
  • 81.3 (n)
  • 78.2 (a)
oppossum
(Monodelphis domestica)
Mammalia ANXA9 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa9 35
  • 56.26 (n)
  • 47.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia anxa9-prov 35
zebrafish
(Danio rerio)
Actinopterygii ANXA9 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nex-1 36
  • 26 (a)
ManyToMany
nex-3 36
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
ManyToMany
Species with no ortholog for ANXA9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA9 Gene

ENSEMBL:
Gene Tree for ANXA9 (if available)
TreeFam:
Gene Tree for ANXA9 (if available)

Paralogs for ANXA9 Gene

Paralogs for ANXA9 Gene

(15) SIMAP similar genes for ANXA9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANXA9: view

Variants for ANXA9 Gene

Sequence variations from dbSNP and Humsavar for ANXA9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs267732 -- 150,985,192(+) CTCTC(A/T)CACAC intron-variant
rs267733 - 150,986,360(+) GGATG(A/C/G/T)CATCA reference, missense
rs539118 -- 150,993,721(+) cctcc(A/G)cctcc intron-variant
rs771199 -- 150,995,712(+) TTGGA(A/G)GTGCC downstream-variant-500B, utr-variant-3-prime
rs1126952 -- 150,986,627(+) TGGAA(G/T)CATTA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ANXA9 Gene

Variant ID Type Subtype PubMed ID
nsv522317 CNV Loss 19592680
nsv522840 CNV Gain 19592680

Variation tolerance for ANXA9 Gene

Residual Variation Intolerance Score: 95.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANXA9 Gene

HapMap Linkage Disequilibrium report
ANXA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA9 Gene

Disorders for ANXA9 Gene

Relevant External Links for ANXA9

Genetic Association Database (GAD)
ANXA9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANXA9
genes like me logo Genes that share disorders with ANXA9: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA9 Gene

Publications for ANXA9 Gene

  1. Human annexin 31 genetic mapping and origin. (PMID: 9931420) Morgan R.O. … Fernandez M.P. (Gene 1999) 2 23 67
  2. Expression profile and structural divergence of novel human annexin 31. (PMID: 9742942) Morgan R.O. … Fernandez M.-P. (FEBS Lett. 1998) 2 23 67
  3. How does acantholysis occur in pemphigus vulgaris: a critical review. (PMID: 16776715) Lanza A. … Gombos F. (J. Cutan. Pathol. 2006) 23 67
  4. Fine mapping of genes on sheep chromosome 1 and their association with milk traits. (PMID: 16734677) Calvo J.H. … Serrano M. (Anim. Genet. 2006) 23 67
  5. Structural and functional characterisation of the mouse annexin A9 promoter. (PMID: 15590064) Chlystun M. … Gerke V. (Biochim. Biophys. Acta 2004) 23 67

Products for ANXA9 Gene

Sources for ANXA9 Gene

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