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Aliases for ANXA8 Gene

Aliases for ANXA8 Gene

  • Annexin A8 2 3 5
  • Vascular Anticoagulant-Beta 3 4
  • Annexin VIII 3 4
  • Annexin-8 3 4
  • VAC-Beta 3 4
  • ANX8 3 4
  • CH17-360D5.2 3

External Ids for ANXA8 Gene

Previous HGNC Symbols for ANXA8 Gene

  • ANX8

Previous GeneCards Identifiers for ANXA8 Gene

  • GC10M046457
  • GC10P046695
  • GC10P047553
  • GC10P047061
  • GC10P047216
  • GC10P047879
  • GC10P048255

Summaries for ANXA8 Gene

Entrez Gene Summary for ANXA8 Gene

  • This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA8 Gene

ANXA8 (Annexin A8) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA4.

UniProtKB/Swiss-Prot for ANXA8 Gene

  • This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA8 Gene

Genomics for ANXA8 Gene

Regulatory Elements for ANXA8 Gene

Enhancers for ANXA8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANXA8 on UCSC Golden Path with GeneCards custom track

Promoters for ANXA8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANXA8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANXA8 Gene

47,460,162 bp from pter
47,993,768 bp from pter
533,607 bases
Minus strand

Genomic View for ANXA8 Gene

Genes around ANXA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA8 Gene

Proteins for ANXA8 Gene

  • Protein details for ANXA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin A8
    Protein Accession:
    Secondary Accessions:
    • A6NDE6
    • A6NLM1
    • B4DKI1
    • B4DTC9
    • Q5T2P8
    • Q5VTM4
    • Q6GMY3
    • Q9BT34

    Protein attributes for ANXA8 Gene

    327 amino acids
    Molecular mass:
    36881 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ANXA8 Gene

    Alternative splice isoforms for ANXA8 Gene


neXtProt entry for ANXA8 Gene

Proteomics data for ANXA8 Gene at MOPED

Post-translational modifications for ANXA8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANXA8 Gene

Domains & Families for ANXA8 Gene

Gene Families for ANXA8 Gene

Protein Domains for ANXA8 Gene

Suggested Antigen Peptide Sequences for ANXA8 Gene

Graphical View of Domain Structure for InterPro Entry



  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA8: view

Function for ANXA8 Gene

Molecular function for ANXA8 Gene

GENATLAS Biochemistry:
annexin A8,calcium and phospholipid binding protein,vascular anticoagulation
UniProtKB/Swiss-Prot Function:
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Gene Ontology (GO) - Molecular Function for ANXA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 15644210
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 16638567
GO:0051015 actin filament binding IDA 16638567
genes like me logo Genes that share ontologies with ANXA8: view
genes like me logo Genes that share phenotypes with ANXA8: view

Animal Model Products

miRNA for ANXA8 Gene

miRTarBase miRNAs that target ANXA8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANXA8 Gene

Localization for ANXA8 Gene

Subcellular locations from

Jensen Localization Image for ANXA8 Gene COMPARTMENTS Subcellular localization image for ANXA8 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for ANXA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031902 late endosome membrane IDA 18923148
genes like me logo Genes that share ontologies with ANXA8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA8 Gene

Pathways & Interactions for ANXA8 Gene

SuperPathways for ANXA8 Gene

No Data Available

Interacting Proteins for ANXA8 Gene

Selected Interacting proteins: P13928-ANXA8_HUMAN for ANXA8 Gene via MINT I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ANXA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1900004 negative regulation of serine-type endopeptidase activity IDA 2530088
genes like me logo Genes that share ontologies with ANXA8: view

No data available for Pathways by source and SIGNOR curated interactions for ANXA8 Gene

Drugs & Compounds for ANXA8 Gene

(1) Drugs for ANXA8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ANXA8: view

Transcripts for ANXA8 Gene

mRNA/cDNA for ANXA8 Gene

(16) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANXA8 Gene

Annexin A8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA8 Gene

No ASD Table

Relevant External Links for ANXA8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA8 Gene

mRNA expression in normal human tissues for ANXA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA8 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.7), Skin - Not Sun Exposed (Suprapubic) (x9.1), Vagina (x7.5), and Skin - Sun Exposed (Lower leg) (x6.9).

Protein differential expression in normal tissues from HIPED for ANXA8 Gene

This gene is overexpressed in Cervix (33.0), Skin (14.6), and Saliva (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANXA8 Gene

SOURCE GeneReport for Unigene cluster for ANXA8 Gene Hs.535306

genes like me logo Genes that share expression patterns with ANXA8: view

Protein tissue co-expression partners for ANXA8 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ANXA8 Gene

Orthologs for ANXA8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANXA8L1 35
  • 89.78 (n)
  • 92.33 (a)
(Canis familiaris)
Mammalia ANXA8L1 35
  • 89.33 (n)
  • 90.77 (a)
(Mus musculus)
Mammalia Anxa8 35
  • 88.75 (n)
  • 92.33 (a)
(Pan troglodytes)
Mammalia ANXA8L1 35
  • 98.98 (n)
  • 99.08 (a)
(Rattus norvegicus)
Mammalia Anxa8 35
  • 88.65 (n)
  • 92.94 (a)
(Gallus gallus)
Aves ANXA8 35
  • 72.6 (n)
  • 73.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 37
  • 49 (a)
AnnX 37
  • 48 (a)
Anxb11 37
  • 46 (a)
(Caenorhabditis elegans)
Secernentea nex-1 37
  • 42 (a)
nex-2 37
  • 47 (a)
nex-3 37
  • 35 (a)
Species with no ortholog for ANXA8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ANXA8 Gene

Gene Tree for ANXA8 (if available)
Gene Tree for ANXA8 (if available)

Paralogs for ANXA8 Gene

genes like me logo Genes that share paralogs with ANXA8: view

Variants for ANXA8 Gene

Sequence variations from dbSNP and Humsavar for ANXA8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_000604 -
VAR_030630 -
rs1419176 -- 47,909,298(+) ATAGA(C/T)ACAAA intron-variant
rs1573207 -- 47,910,203(+) CAGAA(G/T)GGCAG intron-variant
rs1813597 -- 47,646,607(+) aatat(A/G)accct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA8 Gene

Variant ID Type Subtype PubMed ID
dgv252e1 CNV Complex 17122850
esv2750898 CNV Loss 17911159
dgv254e1 CNV Complex 17122850
nsv516485 CNV Gain+Loss 19592680
nsv895114 CNV Gain 21882294
esv34875 CNV Gain 17911159
nsv510991 OTHER Complex 20534489
dgv256e1 CNV Complex 17122850
dgv257e1 CNV Complex 17122850
esv22204 CNV Gain+Loss 19812545
dgv258e1 CNV Complex 17122850
nsv8636 CNV Gain+Loss 18304495
nsv436102 CNV Deletion 17901297
nsv7203 OTHER Inversion 18451855
esv2736152 CNV Deletion 23290073
dgv655n71 CNV Loss 21882294
nsv895128 CNV Gain+Loss 21882294
dgv656n71 CNV Gain 21882294
esv2736163 CNV Deletion 23290073
dgv259e1 CNV Complex 17122850
dgv260e1 CNV Complex 17122850
dgv657n71 CNV Gain 21882294
nsv895135 CNV Loss 21882294
dgv660n71 CNV Gain 21882294
dgv661n71 CNV Gain 21882294
dgv262e1 CNV Complex 17122850
dgv23e55 CNV Loss 17911159
dgv24e55 CNV Gain 17911159
nsv820817 CNV Duplication 20802225
dgv662n71 CNV Loss 21882294
dgv663n71 CNV Gain+Loss 21882294
nsv821667 CNV Gain 15273396
nsv470934 CNV Gain 18288195
dgv664n71 CNV Gain 21882294
nsv818758 CNV Gain 17921354
dgv665n71 CNV Gain 21882294
dgv264e1 CNV Complex 17122850
nsv831853 CNV Gain 17160897
nsv895181 CNV Gain 21882294
dgv666n71 CNV Gain 21882294
nsv831854 CNV Gain 17160897
esv2663732 CNV Deletion 23128226
nsv467059 CNV Gain 19166990
esv21870 CNV Gain+Loss 19812545
nsv895340 CNV Gain 21882294
nsv831860 CNV Gain 17160897
dgv269e1 CNV Complex 17122850
dgv696n71 CNV Gain 21882294
nsv895342 CNV Loss 21882294
nsv895343 CNV Gain 21882294
nsv895344 CNV Loss 21882294
nsv831861 CNV Loss 17160897

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for ANXA8 Gene

Disorders for ANXA8 Gene

Relevant External Links for ANXA8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANXA8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA8 Gene

Publications for ANXA8 Gene

  1. The crystal structure of annexin A8 is similar to that of annexin A3. (PMID: 15644210) Rety S. … Lewit-Bentley A. (J. Mol. Biol. 2005) 3 4 67
  2. TaqI polymorphisms at the annexin VIII locus (ANX8). (PMID: 1364010) Chambers J.A. … Mulligan L.M. (Hum. Mol. Genet. 1992) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Involvement of annexin A8 in the properties of pancreatic cancer. (PMID: 23001853) Hata H. … Nakadate T. (Mol. Carcinog. 2014) 3
  5. Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63. (PMID: 24769558) Poeter M. … Rescher U. (Nat Commun 2014) 3

Products for ANXA8 Gene

Sources for ANXA8 Gene