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ANXA8 Gene

protein-coding   GIFtS: 53

GC10P047879
annexin A8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ANX8)
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Aliases &
Descriptions
for ANXA8

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
ANX8 2, 3
Annexin-8 3
FLJ53095 2
VAC-beta 3
Descriptions
Annexin VIII 3
Vascular anticoagulant-beta 3
annexin A8 2
External Ids
HGNC: 5461
Entrez Gene: 6531452
UniProtKB: P139283
Ensembl: ENSG000001653907
Search outside databases for aliases for ANXA8 gene

Previous GC identifers: GC10M046457 GC10P046695 GC10P047553 GC10P047061 GC10P047216

Summaries
for ANXA8

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for ANXA8:
This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid
binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits
the thromboplastin-specific complex. Overexpression of this gene has been associated with acute
myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on
the long arm of chromosome 10. [provided by RefSeq]

UniProtKB/Swiss-Prot: ANXA8_HUMAN, P13928
Function: This protein is an anticoagulant protein that acts as an indirect inhibitor of the
thromboplastin-specific complex, which is involved in the blood coagulation cascade

Genomic Location
for ANXA8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ANXA8 gene  

Entrez Gene cytogenetic band: 10q11.22   Ensembl cytogenetic band:  10q11.22   HGNC cytogenetic band: 10q11.22

ANXA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P047879:     (about GC identifiers)

Start:
 47,875,231 bp from pter
End:
 47,891,375 bp from pter
Size:
 16,145 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000010.9  NT_030772.10  

Proteins
for ANXA8

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ANXA8_HUMAN, P13928 (See protein sequence)
Recommended Name: Annexin A8  
Size: 327 amino acids; 36881 Da
PDB structure from and Proteopedia :
1W3W (3D)    1W45 (3D)    
Secondary accessions: Q5VTM4 Q6GMY3 Q9BT34

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_001035173.1  

    ENSEMBL proteins: 
    ENSP00000341674 ENSP00000350350 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Annexin VIII)
    Human Recombinant Proteins from Abnova (ANXA8)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for ANXA8: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Annexin VIII), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ANXA8)
    Novus Biologicals Antibodies for ANXA8

    Assays for ANXA8: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for ANXA8

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro domains/families:
     IPR009115 AnnexinVIII
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR018502 Annexin_repeat


       GeneDecks  ANXA8 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P13928

    ProtoNet protein and cluster: P13928

    2 Blocks protein families:
    IPB001464 Annexin
    IPB002392 Annexin type V signature


    UniProtKB/Swiss-Prot: ANXA8_HUMAN, P13928
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats

    Gene Function
    for ANXA8

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 15): NM_001040084

                  Applied Biosystems Silencer® siRNAs for ANXA8

                  Sigma-Aldrich siRNA for ANXA8  
                         Sigma-Aldrich shRNA for ANXA8  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ANXA8
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001040084
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001040084
                                     untagged cDNA clone in CMV expression vector: NM_001040084 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001040084

    UniProtKB/Swiss-Prot: ANXA8_HUMAN, P13928
    Function: This protein is an anticoagulant protein that acts as an indirect inhibitor of the
    thromboplastin-specific complex, which is involved in the blood coagulation cascade

    Genatlas biochemistry entry for ANXA8:
    annexin A8,calcium and phospholipid binding protein,vascular anticoagulation

    Pathways & Interactions
    for ANXA8

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5 Interacting proteins for ANXA8 (P139282 ENSP000003416743) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRPX2ENSP000003620953STRING (score=.948)
    TCF3ENSP000002629653STRING (score=.898)
    HLFENSP000002260673STRING (score=.774)
    RARAENSP000003167693STRING (score=.7)
    --P681352MINT-1892991
    About this table

    Drugs & Compounds
    for ANXA8

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ANXA8

    Transcripts
    for ANXA8

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 15): NM_001040084

                  Sigma-Aldrich siRNA for ANXA8  
                         Sigma-Aldrich shRNA for ANXA8  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001040084  

    REFSEQ mRNAs for ANXA8 gene: 

    NM_001040084.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001040084  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001040084
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001040084
                                     untagged cDNA clone in CMV expression vector: NM_001040084 

    Additional cDNA sequence: 

    AK296573.1 AK298761.1 AK300139.1 AK300158.1 BC004376.1 BC073755.1 BC127791.1 M81844.1 
    Z36830.1 

    4 DOTS entries:

    DT.100759288  DT.102840040  DT.95293157  DT.100701487 

    highest scoring ESTs for ANXA8:

    AI659002 AL575137 AL577550 AW796186 AW799128 BE009242 BE616306 BF688946 BF689033 BF737316 

    Unigene Cluster for ANXA8:

    Annexin A8
    Hs.535306  [show with all ESTs]
    Unigene Representative Sequence: BC127791


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000344416  ENST00000357718  

    Expression
    for ANXA8

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ANXA8 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ANXA8

    1 / 2 / 3

    3 probe-sets matching ANXA8 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37954_at2, 3 U95-A 3 1.00 0.33 1.00 1.00 X16662 1.00 0.72 0.87 1

    		203074_at2, 3 U133-A 3 1.00 0.33 -- -- NM_001630 0.60 1.00 0.82 1

    		203074_at2 U133Plus2 3 1.00 0.33 -- -- -- -- -- -- --
    GeneDecks  ANXA8 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CCCTCAGCAC

    SOURCE GeneReport for Unigene cluster: Hs.535306

    Expression variation in blood from EXPOLDB for ANXA8

    Orthologs
    for ANXA8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ANXA8 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ANXA8L11   -- annexin A8-like 1 89.33(n)
    90.77(a)    		 479270  XM_536412.2  XP_536412.2 
    chimpanzee
    (Pan troglodytes)    		 ANXA8L11   -- annexin A8-like 1 98.98(n)
    99.08(a)    		 450881  XM_001161209.1  XP_001161209.1 
    cow
    (Bos taurus)    		 ANXA8L11   -- annexin A8-like 1 89.78(n)
    92.33(a)    		 281627  NM_174241.2  NP_776666.1 
    rat
    (Rattus norvegicus)    		 Anxa81   -- annexin A8 88.65(n)
    92.94(a)    		 306283  NM_001031654.1  NP_001026824.1 
    mouse
    (Mus musculus)    		 Anxa81   -- annexin A8 88.75(n)
    92.33(a)    		 11752  NM_013473.3  NP_038501.2 
    About this table        Species with no ortholog for ANXA8

    ENSEMBL Gene Tree for ANXA8

    Paralogs
    for ANXA8

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ANXA8 gene
    ANXA8L11 2  ANXA62  ANXA52  ANXA8L22  ANXA42  ANXA72  

    SNPs/Variants
    for ANXA8

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		  --

    Disorders & Mutations
    for ANXA8

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 602396

    Medical News
    for ANXA8

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for ANXA8

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/12 PubMed articles for ANXA8 gene (see all 12 ):

    Search for ANXA8

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ANXA8

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 653145 HGNC: 546 Ensembl:ENSG00000165390 euGenes: HUgn653145 ECgene: ANXA8
    H-InvDB: ANXA8

    Other Databases showing ANXA8

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing ANXA8

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for ANXA8 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for ANXA8

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for ANXA8

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ANXA8:
     TaqMan ® Gene Expression Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ANXA8-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ANXA8 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ANXA8 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

     Recombinant Proteins (ANXA8)
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     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (Annexin VIII)
     Antibodies (Annexin VIII)
     Search OriGene for ANXA8
     Search Tocris compounds for ANXA8




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for ANXA8

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