ANXA8 Gene
protein-coding GIFtS: 51
GCID: GC10P048255
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annexin A8
(Previous symbol: ANX8)
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Aliases
for ANXA8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Annexin A81 2 | | VAC-Beta1 | | ANX81 2 3 | | Annexin-83 | | Annexin VIII2 3 | | Annexin-83 | | Vascular Anticoagulant-Beta2 3 | | |
Export aliases for ANXA8 gene to outside databasesPrevious GC identifers: GC10M046457 GC10P046695 GC10P047553 GC10P047061 GC10P047216 GC10P047879 |
Summaries
for ANXA8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ANXA8:
This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins.The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex.Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy ofthis gene is found in close proximity on the long arm of chromosome 10. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ANXA8_HUMAN, P13928Function: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specificcomplex, which is involved in the blood coagulation cascade
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Genomic Views
for ANXA8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030772.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANXA8 gene promoter:
AML1a MEF-2 YY1 E47 MEF-2A PPAR-alpha FAC1 SEF-1 (1) aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANXA8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.22 Ensembl cytogenetic band: 10q11.22 HGNC cytogenetic band: 10q11.22ANXA8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P048255: view genomic region
(about GC identifiers)
Start:
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48,255,225 bp from pter |
End:
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48,271,369 bp from pter |
Size:
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16,145 bases |
Orientation:
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plus strand |
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Proteins
for ANXA8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANXA8_HUMAN, P13928 (See
protein sequence)Recommended Name: Annexin A8 Size: 327 amino acids; 36881 Da
2 PDB 3D structures from  and Proteopedia  for ANXA8:1W3W (3D)
1W45 (3D)
Secondary accessions: A6NLM1 Q5VTM4 Q6GMY3 Q9BT34Explore the universe of human proteins at neXtProt for ANXA8: NX_P13928
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P13928
ANXA8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001035173.1 NP_001258631.1 NP_001258632.1
ENSEMBL proteins: ENSP00000350350 ENSP00000341674 ENSP00000411799 ENSP00000445192
Human Recombinant Protein Products:
ANXA8 Antibody Products:
Assay Products for ANXA8: |
Protein
Domains /
Families
for ANXA8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANXA8 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P13928ProtoNet protein and cluster: P13928 2 Blocks protein families: IPB001464 Annexin IPB002392 Annexin type V signature
UniProtKB/Swiss-Prot: ANXA8_HUMAN, P13928Domain: A pair of annexin repeats may form one binding site for calcium and phospholipidSimilarity: Belongs to the annexin familySimilarity: Contains 4 annexin repeats |
Function
for ANXA8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ANXA8_HUMAN, P13928Function: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specificcomplex, which is involved in the blood coagulation cascade Genatlas biochemistry entry for ANXA8:annexin A8,calcium and phospholipid binding protein,vascular anticoagulation
Clone
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OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA8 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- | | GO:0005544 | calcium-dependent phospholipid binding |
IEA | -- |
ANXA8 for ontologies About GeneDecksing
|
Pathways & Interactions
for ANXA8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANXA8
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for ANXA8 (P139282, 3 ENSP000003416744) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007596 | blood coagulation |
IEA | -- |
ANXA8 for ontologies About GeneDecksing
|
Drugs & Compounds
for ANXA8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANXA8
1 HMDB Compound for ANXA8 About this table
Search CenterWatch for drugs/clinical trials and news about ANXA8
|
Transcripts
for ANXA8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANXA8 gene (3 alternative transcripts): NM_001040084.2 NM_001271702.1 NM_001271703.1 Unigene Cluster for ANXA8: Annexin A8 Hs.535306 [show with all ESTs]Unigene Representative Sequence: NM_0012717024 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357718(uc010qgf.1 uc021ppw.1) ENST00000344416(uc010qgg.2 uc001jev.3 uc010qgh.2 uc010qgi.2)
ENST00000456111 ENST00000535874
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANXA8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANXA8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANXA8 (NM_001630) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANXA8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA8 |
Additional cDNA sequence: AK296573.1 AK298761.1 AK300139.1 AK300158.1 BC004376.1 BC073755.1 M81844.1 Z36830.1 4 DOTS entries: DT.100759288 DT.102840040 DT.95293157 DT.100701487
GeneLoc Exon Structure
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Expression
for ANXA8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANXA8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTCAGCAC
About this image
See ANXA8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANXA8
SOURCE GeneReport for Unigene cluster: Hs.535306
SABiosciences Custom PCR Arrays for ANXA8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANXA8
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ANXA8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANXA8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANXA8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA8 |
Orthologs
for ANXA8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ANXA8 gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for ANXA8 (if available)
TreeFam Gene Tree for ANXA8 (if available) |
Paralogs
for ANXA8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANXA8 gene
- ANXA8L11 2 ANXA8L21 2 ANXA32 ANXA62 ANXA12 ANXA52 ANXA92 ANXA22
- ANXA72 ANXA112 ANXA102 ANXA42 ANXA132
15 SIMAP similar genes for ANXA8 using alignment to 4 protein entries: ANXA8_HUMAN (see all proteins):ANXA8L2 ANXA8L1 DKFZp686H02120 ANXA2 ANXA6 ANXA3
ANXA5 ANXA11 ANXA4 ANXA1 ANXA10 ANXA7
ANXA13 ANXA2P2 ANXA9
ANXA8 for paralogs About GeneDecksing
|
Genomic Variants
for ANXA8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANXA8 (48255225 - 48271369 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 37 variations for ANXA8
15/37 CNVs (see all 37): 9150 3798 85254 8646 34572 85235 48545 0307 31728 9640 65653 48541 48535 48542 29593 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for ANXA8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANXA8 for disorders About GeneDecksing
OMIM gene information: 602396
OMIM disorders: --
9  diseases for ANXA8: About MalaCardsleukemia acute promyelocytic leukemia adenosquamous carcinoma hepatocellular carcinoma
pancreatic cancer cholangiocarcinoma breast cancer pancreatitis
carcinoma
Export disorders for ANXA8 gene to outside databases
|
Publications
for ANXA8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANXA8 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with ANXA8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Specific expression of the annexin VIII gene in acute promyelocytic leukemia. (PubMed id 1313714)1, 2 Chang K.S.... Stass S.A. (1992)
- TaqI polymorphisms at the annexin VIII locus (ANX8). (PubMed id 1364010)1, 3 Chambers J.A....Mulligan L.M. (1992)
- The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Bone matrix regulates osteoclast differentiation and annexin A8 gene expression. (PubMed id 21344395)1 Crotti T.N....McHugh K.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Annexin A8 regulates late endosome organization and function. (PubMed id 18923148)1 Goebeler V....Rescher U. (2008)
- Annexin A8 displays unique phospholipid and F-actin binding properties. (PubMed id 16638567)1 Goebeler V....Rescher U. (2006)
- Pan-genome isolation of low abundance transcripts using SAGE tag. (PubMed id 17113583)1 Kim Y.C....Wang S.M. (2006)
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External Searches for ANXA8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ANXA8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANXA8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANXA8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ANXA8 gene:
Search GeneIP for patents involving ANXA8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANXA8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ANXA8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA8 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA8 |
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