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Aliases for ANXA8 Gene

Aliases for ANXA8 Gene

  • Annexin A8 2 3 5
  • Vascular Anticoagulant-Beta 3 4
  • Annexin VIII 3 4
  • Annexin-8 3 4
  • VAC-Beta 3 4
  • ANX8 3 4
  • CH17-360D5.2 3

External Ids for ANXA8 Gene

Previous HGNC Symbols for ANXA8 Gene

  • ANX8

Previous GeneCards Identifiers for ANXA8 Gene

  • GC10M046457
  • GC10P046695
  • GC10P047553
  • GC10P047061
  • GC10P047216
  • GC10P047879
  • GC10P048255

Summaries for ANXA8 Gene

Entrez Gene Summary for ANXA8 Gene

  • This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA8 Gene

ANXA8 (Annexin A8) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is LINC00842.

UniProtKB/Swiss-Prot for ANXA8 Gene

  • This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA8 Gene

Genomics for ANXA8 Gene

Regulatory Elements for ANXA8 Gene

Enhancers for ANXA8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ANXA8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANXA8 Gene

Chromosome:
10
Start:
47,460,162 bp from pter
End:
47,993,768 bp from pter
Size:
533,607 bases
Orientation:
Minus strand

Genomic View for ANXA8 Gene

Genes around ANXA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA8 Gene

Proteins for ANXA8 Gene

  • Protein details for ANXA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13928-ANXA8_HUMAN
    Recommended name:
    Annexin A8
    Protein Accession:
    P13928
    Secondary Accessions:
    • A6NDE6
    • A6NLM1
    • B4DKI1
    • B4DTC9
    • Q5T2P8
    • Q5VTM4
    • Q6GMY3
    • Q9BT34

    Protein attributes for ANXA8 Gene

    Size:
    327 amino acids
    Molecular mass:
    36881 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ANXA8 Gene

    Alternative splice isoforms for ANXA8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANXA8 Gene

Post-translational modifications for ANXA8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANXA8 Gene

Domains & Families for ANXA8 Gene

Gene Families for ANXA8 Gene

Protein Domains for ANXA8 Gene

Suggested Antigen Peptide Sequences for ANXA8 Gene

Graphical View of Domain Structure for InterPro Entry

P13928

UniProtKB/Swiss-Prot:

ANXA8_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
Similarity:
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA8: view

Function for ANXA8 Gene

Molecular function for ANXA8 Gene

GENATLAS Biochemistry:
annexin A8,calcium and phospholipid binding protein,vascular anticoagulation
UniProtKB/Swiss-Prot Function:
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Gene Ontology (GO) - Molecular Function for ANXA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 15644210
GO:0005544 calcium-dependent phospholipid binding IDA 2530088
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 16638567
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 16638567
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA 16638567
genes like me logo Genes that share ontologies with ANXA8: view
genes like me logo Genes that share phenotypes with ANXA8: view

Animal Model Products

CRISPR Products

miRNA for ANXA8 Gene

miRTarBase miRNAs that target ANXA8

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANXA8 Gene

Localization for ANXA8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA8 Gene COMPARTMENTS Subcellular localization image for ANXA8 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for ANXA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 18923148
GO:0005886 plasma membrane IDA 18923148
GO:0031902 late endosome membrane IDA 18923148
genes like me logo Genes that share ontologies with ANXA8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA8 Gene

Pathways & Interactions for ANXA8 Gene

SuperPathways for ANXA8 Gene

No Data Available

Interacting Proteins for ANXA8 Gene

Gene Ontology (GO) - Biological Process for ANXA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007032 endosome organization IMP 18923148
GO:0007596 blood coagulation IEA --
GO:0016197 endosomal transport IMP 18923148
GO:1900004 negative regulation of serine-type endopeptidase activity IDA 2530088
GO:1900138 negative regulation of phospholipase A2 activity IDA 2530088
genes like me logo Genes that share ontologies with ANXA8: view

No data available for Pathways by source and SIGNOR curated interactions for ANXA8 Gene

Drugs & Compounds for ANXA8 Gene

(1) Drugs for ANXA8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ANXA8: view

Transcripts for ANXA8 Gene

mRNA/cDNA for ANXA8 Gene

(8) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANXA8 Gene

Annexin A8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA8 Gene

No ASD Table

Relevant External Links for ANXA8 Gene

GeneLoc Exon Structure for
ANXA8
ECgene alternative splicing isoforms for
ANXA8

Expression for ANXA8 Gene

mRNA expression in normal human tissues for ANXA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA8 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.7), Skin - Not Sun Exposed (Suprapubic) (x9.1), Vagina (x7.5), and Skin - Sun Exposed (Lower leg) (x6.9).

Protein differential expression in normal tissues from HIPED for ANXA8 Gene

This gene is overexpressed in Cervix (33.0), Skin (14.6), and Saliva (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANXA8 Gene



Protein tissue co-expression partners for ANXA8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANXA8 Gene:

ANXA8

SOURCE GeneReport for Unigene cluster for ANXA8 Gene:

Hs.535306
genes like me logo Genes that share expression patterns with ANXA8: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ANXA8 Gene

Orthologs for ANXA8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANXA8L1 34
  • 89.78 (n)
  • 92.33 (a)
dog
(Canis familiaris)
Mammalia ANXA8L1 34
  • 89.33 (n)
  • 90.77 (a)
mouse
(Mus musculus)
Mammalia Anxa8 34
  • 88.75 (n)
  • 92.33 (a)
chimpanzee
(Pan troglodytes)
Mammalia ANXA8L1 34
  • 98.98 (n)
  • 99.08 (a)
rat
(Rattus norvegicus)
Mammalia Anxa8 34
  • 88.65 (n)
  • 92.94 (a)
chicken
(Gallus gallus)
Aves ANXA8 34
  • 72.6 (n)
  • 73.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 36
  • 49 (a)
AnnX 36
  • 48 (a)
Anxb11 36
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea nex-1 36
  • 42 (a)
nex-2 36
  • 47 (a)
nex-3 36
  • 35 (a)
Species where no ortholog for ANXA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ANXA8 Gene

ENSEMBL:
Gene Tree for ANXA8 (if available)
TreeFam:
Gene Tree for ANXA8 (if available)

Paralogs for ANXA8 Gene

genes like me logo Genes that share paralogs with ANXA8: view

Variants for ANXA8 Gene

Sequence variations from dbSNP and Humsavar for ANXA8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_000604 -
VAR_030630 -
rs1936340 -- 47,904,495(+) AGTTC(A/G)TTTAT intron-variant
rs1936341 -- 47,904,516(+) CACAC(A/T)CGACA intron-variant
rs1936352 -- 47,909,797(+) AGATT(C/T)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA8 Gene

Variant ID Type Subtype PubMed ID
nsv1118173 CNV deletion 24896259
nsv831861 CNV loss 17160897
nsv947961 CNV duplication 23825009

Relevant External Links for ANXA8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANXA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ANXA8 Gene

Disorders for ANXA8 Gene

Relevant External Links for ANXA8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANXA8

No disorders were found for ANXA8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA8 Gene

Publications for ANXA8 Gene

  1. The crystal structure of annexin A8 is similar to that of annexin A3. (PMID: 15644210) Rety S. … Lewit-Bentley A. (J. Mol. Biol. 2005) 3 4 65
  2. TaqI polymorphisms at the annexin VIII locus (ANX8). (PMID: 1364010) Chambers J.A. … Mulligan L.M. (Hum. Mol. Genet. 1992) 2 3 65
  3. Specific expression of the annexin VIII gene in acute promyelocytic leukemia. (PMID: 1313714) Chang K.S. … Stass S.A. (Blood 1992) 3 4 65
  4. Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha. (PMID: 2530088) Hauptmann R. … Reutelingsperger C.P.M. (Eur. J. Biochem. 1989) 3 4 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for ANXA8 Gene

Sources for ANXA8 Gene

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