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ANXA7 Gene

protein-coding   GIFtS: 68
GCID: GC10M075135

Annexin A7


(Previous symbol: ANX7)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Annexin A71 2     SYNEXIN2
ANX71 2 3     annexin-72
SNX2 3 5     Annexin-73
Annexin VII2 3     Synexin3

External Ids:    HGNC: 5451   Entrez Gene: 3102   Ensembl: ENSG000001382797   OMIM: 1863605   UniProtKB: P200733   
ORGUL members:         

Export aliases for ANXA7 gene to outside databases

Previous GC identifers: GC10M073913 GC10M074238 GC10M075027 GC10M074479 GC10M074805 GC10M069130


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANXA7 Gene:
Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII
gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in
two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their
N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is
prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the
use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51
kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of
299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural
analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties,
including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. (provided by RefSeq,
Jul 2008)

GeneCards Summary for ANXA7 Gene:
ANXA7 (annexin A7) is a protein-coding gene. GO annotations related to this gene include calcium-dependent phospholipid binding and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANXA7_HUMAN, P20073
Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis

Gene Wiki entry for ANXA7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANXA7 gene promoter:
         Nkx3-1 v2   Nkx3-1   Nkx3-1 v4   Nkx3-1 v3   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANXA7 promoter sequence
   Search Chromatin IP Primers for ANXA7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANXA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.2   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q22.2

ANXA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA7 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M075135:  view genomic region     (about GC identifiers)

Start:
75,134,859 bp from pter      End:
75,173,841 bp from pter
Size:
38,983 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANXA7_HUMAN, P20073 (See protein sequence)
Recommended Name: Annexin A7  
Size: 488 amino acids; 52739 Da
Subunit: Interacts with PDCD6
Sequence caution: Sequence=CAI52483.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5F2H3 Q5T0M6 Q5T0M7
Alternative splicing: 2 isoforms:  P20073-1   P20073-2   

Explore the universe of human proteins at neXtProt for ANXA7: NX_P20073

Explore proteomics data for ANXA7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys199, Lys430
  • Modification sites at PhosphoSitePlus

  • See ANXA7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001147.1  NP_004025.1  

    ENSEMBL proteins: 
     ENSP00000362012   ENSP00000362010   ENSP00000378317   ENSP00000442864  

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    antibodies-online proteins for ANXA7 (20 products) 

     
    antibodies-online peptides for ANXA7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANXA: Annexins

    4 InterPro protein domains:
     IPR018502 Annexin_repeat
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR013286 AnnexinVII

    Graphical View of Domain Structure for InterPro Entry P20073

    ProtoNet protein and cluster: P20073

    2 Blocks protein domains:
    IPB001464 Annexin
    IPB002391 Annexin type IV signature


    UniProtKB/Swiss-Prot: ANXA7_HUMAN, P20073
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    Find genes that share domains with ANXA7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANXA7_HUMAN, P20073
    Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis

         Genatlas biochemistry entry for ANXA7:
    annexin A7,two forms,47kDa,51kDa,calcium and phospholipid binding protein,synexin,expressed in adrenal medullary
    cells,skeletal muscle,brain,liver

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI12445460
    GO:0005544calcium-dependent phospholipid binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0048306calcium-dependent protein binding IPI12445460
         
    Find genes that share ontologies with ANXA7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ANXA7:
     Increased cell death in breast 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Anxa7):
     cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  skeleton 
     tumorigenesis 

    Find genes that share phenotypes with ANXA7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ANXA7: Anxa7tm1Pll Anxa7tm1Ngl

       genOway: Develop your customized and physiologically relevant rodent model for ANXA7

    miRNA
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    miRTarBase miRNAs that target ANXA7:
    hsa-mir-196a-5p (MIRT048217), hsa-mir-324-5p (MIRT043161), hsa-mir-122-5p (MIRT023283)

    Block miRNA regulation of human, mouse, rat ANXA7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANXA7 (see all 26):
    hsa-miR-3689b hsa-miR-3910 hsa-miR-16-2* hsa-miR-520d-5p hsa-miR-137 hsa-miR-4272 hsa-miR-10b hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidANXA7 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ANXA7 (NM_001156)
    Sino Biological Human cDNA Clone for ANXA7
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA7

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    nucleus4
    cytosol2
    endosome2
    plasma membrane2
    cytoskeleton1
    extracellular1
    golgi apparatus1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10672515
    GO:0005635nuclear envelope IEA--
    GO:0005789endoplasmic reticulum membrane IDA10672515
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with ANXA7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANXA7 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoskeletal Signaling
    Cytoskeletal Signaling
    2Ca, cAMP and Lipid Signaling
    Ca, cAMP and Lipid Signaling


    Find genes that share SuperPaths with ANXA7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for ANXA7
        Ca, cAMP and Lipid Signaling
    Cytoskeletal Signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANXA7
    Interactions:

        GeneGlobe Interaction Network for ANXA7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for ANXA7 (P200732, 3 ENSP000003620104) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-8248031 I2D: score=2 
    DDAH2O958652, 3MINT-8248252 I2D: score=2 
    ENSG00000096155P463792, 3MINT-8248031 I2D: score=2 
    ENSG00000206395O958652, 3MINT-8248252 I2D: score=2 
    ENSG00000225635O958652, 3MINT-8248252 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis IEA--
    GO:0007599hemostasis IEA--
    GO:0008283cell proliferation IEA--
    GO:0008360regulation of cell shape IEA--
    GO:0009651response to salt stress IEA--

    Find genes that share ontologies with ANXA7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANXA7

    1 HMDB Compound for ANXA7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    6 Novoseek inferred chemical compound relationships for ANXA7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phospholipid 56 3 8670145 (1), 9078249 (1), 16843057 (1)
    phosphatidylserine 51.8 2 19910682 (1)
    calcium 32.1 20 9078249 (6), 2170654 (1), 1318099 (1), 2184163 (1) (see all 9)
    phosphatidylcholine 24 1 17765009 (1)
    lipid 4.97 6 9078249 (2), 17765009 (2), 11895795 (1), 2139437 (1)
    arachidonic acid 3.81 3 9078249 (2), 17018618 (1)



    Find genes that share compounds with ANXA7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANXA7 gene (2 alternative transcripts): 
    NM_001156.3  NM_004034.2  

    Unigene Cluster for ANXA7:

    Annexin A7
    Hs.631827  [show with all ESTs]
    Unigene Representative Sequence: NM_004034
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372921(uc001jua.2 uc010qki.1 uc009xre.3 uc009xrf.1)
    ENST00000372919(uc001jtz.2) ENST00000463788 ENST00000492380 ENST00000394847
    ENST00000535178
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ANXA7 (see all 26):
    hsa-miR-3689b hsa-miR-3910 hsa-miR-16-2* hsa-miR-520d-5p hsa-miR-137 hsa-miR-4272 hsa-miR-10b hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidANXA7 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ANXA7
      QuantiFast Probe-based Assays in human, mouse, rat ANXA7

    Additional mRNA sequence: 

    AB062429.1 AK222552.1 AK295319.1 AK300086.1 AK301681.1 AK307772.1 AK309141.1 AK312447.1 
    AK313024.1 BC001322.1 BC002632.2 BT007187.1 CR407686.1 J04543.1 M64272.1 

    Selected DOTS entries (see all 27):

    DT.100684618  DT.100684614  DT.100684624  DT.100684623  DT.100707250  DT.100038086  DT.218353  DT.100684616 
    DT.91679511  DT.95359651  DT.97826422  DT.121297658  DT.121297682  DT.92345023  DT.92448036  DT.100692557 
    DT.121297623  DT.121297637  DT.95359631  DT.100038087  DT.100684619  DT.100684620  DT.100684621  DT.121297643 

    Selected AceView cDNA sequences (see all 480):

    BU191934 CR590056 CF146845 BX457713 BC001322 BQ017137 BX360332 CR407686 
    CD677980 BU541070 CB991126 CR623322 CR611487 BM972726 AW955240 AU185847 
    AI275515 AI148137 AA910847 BQ049116 AV717513 BM558105 BF726426 CA434959 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANXA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTATTGC
    ANXA7 Expression
    About this image


    ANXA7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    ANXA7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANXA7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631827

    UniProtKB/Swiss-Prot: ANXA7_HUMAN, P20073
    Tissue specificity: Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in
    liver, lung, kidney, spleen, fibroblasts and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANXA7 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anxa71 , 5 annexin A71, 5 87.01(n)1
    92.34(a)1
      14 (11.53 cM)5
    117501  NM_001110794.11  NP_001104264.11 
     204552615 
    chicken
    (Gallus gallus)
    Aves ANXA71 annexin A7 74.73(n)
    82.72(a)
      423747  NM_001277347.1  NP_001264276.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA76
    annexin A7
    82(a)
    1 ↔ 1
    GL343196.1(848343-860908)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978542 annexin VII 76.61(n)    U16365.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AnnIX3
    Anxb111
    actin binding3
    Annexin B111
    50(a)
    (best of 3)3
    51.13(n)1
    49.84(a)1
      93B103
    326121  NM_078646.31  NP_523370.11 
    worm
    (Caenorhabditis elegans)
    Secernentea nex-21 , 3 Annexin3
    nex-21
    48(a)
    (best of 2)3
    48.04(n)1
    47.7(a)1
      III(10397630-10399688)3
    1764461  NM_001027584.31  NP_001022755.11 


    ENSEMBL Gene Tree for ANXA7 (if available)
    TreeFam Gene Tree for ANXA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANXA7 gene
    ANXA32  ANXA62  ANXA52  ANXA12  ANXA92  ANXA22  ANXA82  ANXA112  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA7 using alignment to 3 protein entries:     ANXA7_HUMAN (see all proteins):
    DKFZp686H02120    ANXA13    ANXA6    ANXA4    ANXA3    ANXA8L2
    ANXA5    ANXA1    ANXA11    ANXA10    ANXA2    ANXA8
    ANXA2P2    ANXA8L1    ANXA9

    Find genes that share paralogs with ANXA7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANXA7 (see all 894)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404806601,2
    C--75134719(+) CTCCA-/GGCCTG 2 -- ds50010--------
    rs606482051,2
    C--75134804(+) GTGAAT/CTATAA 2 -- ds50016Minor allele frequency- C:0.24NA CSA WA EA 362
    rs767336651,2
    C,F--75134907(+) AAACAC/GAGTGG 2 -- ds50012Minor allele frequency- G:0.15CSA WA 120
    rs1127961611,2
    F--75134984(+) TAAAAC/TGAATA 2 -- ds50012Minor allele frequency- T:0.13CSA WA 120
    rs1484187761,2
    --75134993(+) TAAATA/GCTAGA 2 -- ds50010--------
    rs1875904331,2
    --75135106(+) GTAACC/TATGTC 2 -- ds50010--------
    rs1425647891,2
    --75135125(+) AGATAC/TGTAAT 2 -- ds50010--------
    rs1907252181,2
    --75135187(+) CACCAC/TATTGT 2 -- ds50010--------
    rs1826779241,2
    C--75135220(+) TTTATC/TTGTCA 2 -- ut310--------
    rs1868895731,2
    --75135221(+) TTATTA/TGTCAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ANXA7 (75134859 - 75173841 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ANXA7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831911CNV Loss17160897

    Human Gene Mutation Database (HGMD): ANXA7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANXA7
    DNA2.0 Custom Variant and Variant Library Synthesis for ANXA7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186360    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ANXA7:
    Kidney failure

    Find genes that share disorders with ANXA7           About GenesLikeMe

    2 Novoseek inferred disease relationships for ANXA7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 13 14609169 (4), 17018618 (1), 18449914 (1), 18854424 (1) (see all 8)
    cancer 0 6 17018618 (1), 18449914 (1), 17708571 (1), 19610065 (1) (see all 5)

    Genetic Association Database (GAD): ANXA7
    Human Genome Epidemiology (HuGE) Navigator: ANXA7 (1 document)

    Export disorders for ANXA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANXA7 gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with ANXA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10. (PubMed id 7515686)1, 2, 3, 9 Shirvan A.... Burns A.L. (Biochemistry 1994)
    2. Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain. (PubMed id 1825209)1, 2, 9 Magendzo K....Burns A.L. (J. Biol. Chem. 1991)
    3. Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PubMed id 18256029)1, 2, 9 Shibata H....Maki M. (J. Biol. Chem. 2008)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Calcium channel activity of purified human synexin and structure of the human synexin gene. (PubMed id 2542947)1, 2 Burns A.L.... Pollard H.B. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    7. Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII). (PubMed id 9268363)1, 9 Brownawell A.M. and Creutz C.E. (J. Biol. Chem. 1997)
    8. Differential recognition of secretory vesicles by annexins. European Molecular Biology Organization Course &quot;Advanced Techniques for Studying Secretion&quot;. (PubMed id 1533123)1, 9 Creutz C.E....Gomperts B. (Biochem. Biophys. Res. Commun. 1992)
    9. Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription. (PubMed id 17018618)1, 9 Torosyan Y....Srivastava M. (Cancer Res. 2006)
    10. Expression and localisation of annexin VII (synexin) isoforms in differentiating myoblasts. (PubMed id 10672515)1, 9 Clemen C.S....Noegel A.A. (J. Muscle Res. Cell. Motil. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 310 HGNC: 545 AceView: ANXA7 Ensembl:ENSG00000138279 euGenes: HUgn310
    ECgene: ANXA7 H-InvDB: ANXA7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANXA7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANXA7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANXA7 gene:
    Search GeneIP for patents involving ANXA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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