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ANXA6 Gene

protein-coding   GIFtS: 62
GCID: GC05M150460

Annexin A6


(Previous symbol: ANX6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Annexin A61 2     Calcium-Binding Protein P682
ANX61 2 3     calelectrin2
Lipocortin VI2 3     Calphobindin II2
67 KDa Calelectrin2 3     calphobindin-II2
CPB-II2 3     chromobindin-202
p682 3     Annexin-63
p702 3     Calphobindin-II3
CBP682 5     Chromobindin-203
Annexin VI (P68)2     Annexin VI3
annexin-62     Protein III3

External Ids:    HGNC: 5441   Entrez Gene: 3092   Ensembl: ENSG000001970437   OMIM: 1140705   UniProtKB: P081333   

Export aliases for ANXA6 gene to outside databases

Previous GC identifers: GC05M150549 GC05M151077 GC05M150463 GC05M150509 GC05M145626


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANXA6 Gene:
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of
the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The
annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that
consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar
to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in
mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively
spliced transcript variants have been described. (provided by RefSeq, Aug 2010)

GeneCards Summary for ANXA6 Gene:
ANXA6 (annexin A6) is a protein-coding gene. Diseases associated with ANXA6 include kwashiorkor, and marasmus. GO annotations related to this gene include calcium-dependent phospholipid binding and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANXA6_HUMAN, P08133
Function: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores

Gene Wiki entry for ANXA6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANXA6 gene promoter:
         RP58   Elk-1   AML1a   Brachyury   Roaz   E2F-1   CP2   FOXC1   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANXA6 promoter sequence
   Search Chromatin IP Primers for ANXA6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANXA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q33.1

ANXA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M150460:  view genomic region     (about GC identifiers)

Start:
150,480,267 bp from pter      End:
150,537,443 bp from pter
Size:
57,177 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANXA6_HUMAN, P08133 (See protein sequence)
Recommended Name: Annexin A6  
Size: 673 amino acids; 75873 Da
Miscellaneous: Seems to bind one calcium ion with high affinity
1 PDB 3D structure from and Proteopedia for ANXA6:
1M9I (3D)    
Secondary accessions: B7Z8A7 D3DQH4 E9PGK1 Q6ZT79
Alternative splicing: 2 isoforms:  P08133-1   P08133-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANXA6: NX_P08133

Explore proteomics data for ANXA6 at MOPED

Post-translational modifications: 

  • Phosphorylated in response to growth factor stimulation1
  • Ubiquitination2 at Lys9, Lys68, Lys81, Lys102, Lys135, Lys240, Lys377, Lys418, Lys456
  • Modification sites at PhosphoSitePlus

  • See ANXA6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001146.2  NP_001180473.1  

    ENSEMBL proteins: 
     ENSP00000431086   ENSP00000346550   ENSP00000430517   ENSP00000366980   ENSP00000430420  
     ENSP00000428916   ENSP00000430663   ENSP00000430826   ENSP00000430429   ENSP00000430572  
     ENSP00000431078   ENSP00000348889  

    ANXA6 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for ANXA6
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    ANXA6 Antibody Products:

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    Cloud-Clone Corp. CLIAs for ANXA6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANXA: Annexins

    4 InterPro protein domains:
     IPR018502 Annexin_repeat
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR002393 AnnexinVI

    Graphical View of Domain Structure for InterPro Entry P08133

    ProtoNet protein and cluster: P08133

    2 Blocks protein domains:
    IPB001464 Annexin
    IPB002393 Annexin type VI signature


    UniProtKB/Swiss-Prot: ANXA6_HUMAN, P08133
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 8 annexin repeats


    ANXA6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANXA6_HUMAN, P08133
    Function: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores
    Induction: By Epstein-Barr virus (EBV)

         Genatlas biochemistry entry for ANXA6:
    annexin A6,p68 calcium and phospholipid binding protein

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI15576473
    GO:0005544calcium-dependent phospholipid binding IDA2138016
         
    ANXA6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ANXA6:
     Decreased TP53 protein express  Increased G1 DNA content 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Anxa6):
     cardiovascular system  immune system  muscle 

    ANXA6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Anxa6tm1Moss for ANXA6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANXA6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANXA6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANXA6

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANXA6:
    hsa-mir-124-3p (MIRT022347), hsa-mir-324-5p (MIRT043164), hsa-mir-877-3p (MIRT037148)

    Block miRNA regulation of human, mouse, rat ANXA6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ANXA6:
    hsa-miR-3935
    SwitchGear 3'UTR luciferase reporter plasmidANXA6 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ANXA6

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): ANXA6 (NM_001155)
    Sino Biological Human cDNA Clone for ANXA6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA6

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANXA6_HUMAN, P08133: Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome
    fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol3
    cytoskeleton2
    endosome2
    nucleus2
    plasma membrane2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042470melanosome IEA--
    GO:0048471perinuclear region of cytoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    ANXA6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANXA6 About    
    See pathways by source

    SuperPathContained pathways About
    1Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell0.43
    2Prostaglandin Synthesis and Regulation
    Prostaglandin Synthesis and Regulation


    2 BioSystems Pathways for ANXA6
        Calcium Regulation in the Cardiac Cell
    Prostaglandin Synthesis and Regulation



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANXA6
    Interactions:

        GeneGlobe Interaction Network for ANXA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for ANXA6 (P081332, 3 ENSP000003465504) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TJP1Q071572, 3, ENSP000002815374MINT-2984714 I2D: score=3 STRING: ENSP00000281537
    RASA1P209363, ENSP000002743764I2D: score=5 STRING: ENSP00000274376
    S100A1P232973, ENSP000002921694I2D: score=2 STRING: ENSP00000292169
    TPD52P553273, ENSP000003683914I2D: score=2 STRING: ENSP00000368391
    H2AFXP161043, ENSP000003643104I2D: score=1 STRING: ENSP00000364310
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport IEA--
    GO:0006937regulation of muscle contraction IEA--

    ANXA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANXA6

    1 HMDB Compound for ANXA6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for ANXA6 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phospholipid 54.8 26 1839615 (6), 19306927 (3), 9337873 (2), 7662658 (2) (see all 12)
    phosphatidylserine 50.6 3 9480874 (1), 1839615 (1)
    calcium 48.9 97 2168425 (7), 18786929 (5), 1839615 (4), 1831222 (3) (see all 34)
    phosphatidylethanolamine 36.5 2 2138016 (1), 1420158 (1)
    phosphatidylcholine 30.9 4 1828227 (2), 2138016 (1), 1839615 (1)
    atp 24.3 10 10698288 (2), 9310384 (2), 1386288 (1), 16888724 (1) (see all 6)
    actomyosin 18.6 2 11310961 (2)
    lipid 18.2 11 16153422 (4), 11964259 (1), 19306927 (1), 11310961 (1) (see all 7)
    gtp 17.6 5 11964259 (2), 9310384 (1)
    glyceraldehyde 3-phosphate 15.7 3 15801906 (1), 8365543 (1), 8593259 (1)



    ANXA6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANXA6 gene (3 alternative transcripts): 
    NM_001155.4  NM_001193544.1  NM_004033.2  

    Unigene Cluster for ANXA6:

    Annexin A6
    Hs.412117  [show with all ESTs]
    Unigene Representative Sequence: NM_001155
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522664 ENST00000354546(uc003ltl.2 uc003lto.2) ENST00000523714(uc011dcp.2)
    ENST00000377751 ENST00000521512 ENST00000517486 ENST00000519644 ENST00000520054
    ENST00000517707 ENST00000517677 ENST00000521749 ENST00000517757 ENST00000520378
    ENST00000523164 ENST00000519610 ENST00000356496
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ANXA6:
    hsa-miR-3935
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ANXA6
      QuantiFast Probe-based Assays in human, mouse, rat ANXA6

    Additional mRNA sequence: 

    AK126836.1 AK130077.1 AK290672.1 AK298582.1 AK303078.1 BC017046.1 D00510.1 J03578.1 
    Y00097.1 

    23 DOTS entries:

    DT.454712  DT.100660833  DT.95101601  DT.100660830  DT.65287418  DT.120863780  DT.100660835  DT.100660825 
    DT.95108755  DT.100869152  DT.95184892  DT.100000105  DT.100660831  DT.86855446  DT.91853799  DT.95184876 
    DT.95184923  DT.95184926  DT.432029  DT.446479  DT.91899050  DT.92453141  DT.95184891 

    Selected AceView cDNA sequences (see all 447):

    AA318604 CA396749 AA312441 AA594288 BQ013088 CA444780 BX345665 CF132428 
    AL516771 BM904172 AL597725 BQ187981 D00510 BX116688 AA370241 AU105404 
    BC017046 BQ002365 AI872358 BM662240 AU119222 BM716087 AA975225 BI754324 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANXA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAGCCTG
    ANXA6 Expression
    About this image

    ANXA6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANXA6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.412117
        Custom PCR Arrays for ANXA6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANXA6 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anxa61 , 5 annexin A61, 5 89.4(n)1
    94.35(a)1
      11 (32.13 cM)5
    117491  NM_013472.41  NP_038500.21 
     549791085 
    chicken
    (Gallus gallus)
    Aves ANXA61 annexin A6 77.01(n)
    79.01(a)
      395481  NM_204730.1  NP_990061.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA66
    annexin A6
    76(a)
    1 ↔ 1
    2(138143791-138212918)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.135852 Xenopus laevis transcribed sequence with moderate similarity more 75.53(n)    BX847979.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anxa62 annexin A6 74.61(n)   353363  AY178800.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AnnIX3
    AnnX1
    actin binding3
    Annexin X1
    48(a)
    (best of 3)3
    55.91(n)1
    44.52(a)1
      93B103
    330191  NM_001169333.11  NP_001162804.11 


    ENSEMBL Gene Tree for ANXA6 (if available)
    TreeFam Gene Tree for ANXA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANXA6 gene
    ANXA32  ANXA52  ANXA12  ANXA92  ANXA22  ANXA72  ANXA82  ANXA112  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA6 using alignment to 11 protein entries:     ANXA6_HUMAN (see all proteins):
    ANXA7    ANXA3    ANXA5    ANXA11    ANXA4    ANXA8L2
    ANXA13    DKFZp686H02120    ANXA8    ANXA8L1    ANXA2P2    ANXA10
    ANXA2    ANXA1    ANXA9

    ANXA6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANXA6 (see all 1470)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358797701,2
    C--145645775(+) AAAAA-/A/AA  
            
    GTCCG
    2 -- int11NA 2
    rs1815852881,2
    --150479780(+) CAGGGC/TAGGGA 2 -- ds50010--------
    rs737994331,2
    C--150479970(+) CACATC/TGGGCA 2 -- ds50012Minor allele frequency- T:0.11WA 120
    rs1504308881,2
    --150480008(+) TGGGCC/TTGGTT 2 -- ds50010--------
    rs737994341,2
    C,F--150480020(+) AAATGG/AATGAA 2 -- ds50012Minor allele frequency- A:0.05WA 120
    rs786529091,2
    F--150480067(+) AGGGGG/CAACCT 2 -- ds50012Minor allele frequency- C:0.11CSA WA 120
    rs1453066991,2
    --150480253(+) CAGAGA/GCCCTC 2 -- ds50010--------
    rs1490343091,2
    C--150480378(+) CAAGA-/TTTTTT 2 -- ut310--------
    rs119604581,2
    C,F,H--150480520(+) TAGCGC/TGGCCT 2 -- ut3124Minor allele frequency- T:0.25NA MN NS EA WA 3080
    rs608493141,2
    C,F--150480569(+) CAGTTT/GGCCCC 2 -- ut312Minor allele frequency- G:0.11WA 120

    HapMap Linkage Disequilibrium report for ANXA6 (150480267 - 150537443 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ANXA6: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANXA6
    DNA2.0 Custom Variant and Variant Library Synthesis for ANXA6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114070    OMIM disorders: --

    Selected diseases for ANXA6 (see all 31):    
    About MalaCards
    kwashiorkor    marasmus    vaginal cancer    typhoid fever
    vaginitis    malignant hyperthermia susceptibility    malignant hyperthermia    protein-energy malnutrition
    ocular melanoma    osteonecrosis    lynch syndrome    cystic fibrosis
    lateral sclerosis    amyotrophic lateral sclerosis    pneumonia    dilated cardiomyopathy
    melanoma    hodgkin's lymphoma    non-hodgkin lymphoma    lymphoblastic leukemia


    ANXA6 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ANXA6 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    typhoid fever 11.1 1 14662750 (1)
    cystic fibrosis 0.32 4 15528719 (3), 11160019 (1)
    carcinoma squamous cell 0 3 7710945 (1), 7905003 (1)
    necrosis 0 2 19438591 (1), 16896315 (1)
    shock 0 4 17309107 (1), 20137130 (1), 16888724 (1), 17200159 (1)
    pneumonia 0 1 11990909 (1)
    amyotrophic lateral sclerosis 0 1 16896315 (1)
    lymphoma non-hodgkins 0 1 16930137 (1)
    tumors 0 5 16794737 (1), 8752144 (1), 9920419 (1), 15576473 (1) (see all 5)
    alzheimers disease 0 2 8080046 (1)

    Genetic Association Database (GAD): ANXA6
    Human Genome Epidemiology (HuGE) Navigator: ANXA6 (1 document)

    Export disorders for ANXA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANXA6 gene, integrated from 10 sources (see all 215):
    (articles sorted by number of sources associating them with ANXA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family. (PubMed id 3258820)1, 2, 3 Crompton M.R....Crumpton M.J. (EMBO J. 1988)
    2. Structure and properties of calphobindin II, an anticoagulant protein from human placenta. (PubMed id 2139657)1, 2, 9 Yoshizaki H....Maki M. (J. Biochem. 1990)
    3. The structure of recombinant human annexin VI in crystals and membrane-bound. (PubMed id 8709144)1, 2, 9 Benz J.... Voges D. (J. Mol. Biol. 1996)
    4. Polymorphisms in the Annexin gene family and the risk of osteonecrosis of the femoral head in the Korean population. (PubMed id 19345290)1, 4 Kim T.H....Kim S.Y. (Bone 2009)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)1, 2 Aboulaich N.... Vener A.V. (Biochem. J. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Structure and expression of cDNA for calphobindin II, a human placental coagulation inhibitor. (PubMed id 2528541)1, 2 Iwasaki A.... Maki M. (J. Biochem. 1989)
    10. Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins. (PubMed id 2963335)1, 2 Suedhof T.C.... Reynolds G.A. (Proc. Natl. Acad. Sci. U.S.A. 1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 309 HGNC: 544 AceView: ANXA6 Ensembl:ENSG00000197043 euGenes: HUgn309
    ECgene: ANXA6 H-InvDB: ANXA6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ANXA6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ANXA6 gene:
    Search GeneIP for patents involving ANXA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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