Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANXA6 Gene

Aliases for ANXA6 Gene

  • Annexin A6 2 3
  • 67 KDa Calelectrin 3 4
  • Calphobindin-II 3 4
  • Chromobindin-20 3 4
  • Lipocortin VI 3 4
  • Annexin-6 3 4
  • CPB-II 3 4
  • CBP68 3 6
  • ANX6 3 4
  • P68 3 4
  • P70 3 4
  • Calcium-Binding Protein P68 3
  • Annexin VI (P68) 3
  • Calphobindin II 3
  • Calelectrin 3
  • Protein III 4
  • Annexin VI 4

External Ids for ANXA6 Gene

Previous HGNC Symbols for ANXA6 Gene

  • ANX6

Previous GeneCards Identifiers for ANXA6 Gene

  • GC05M150549
  • GC05M150463
  • GC05M150509
  • GC05M150460
  • GC05M145626

Summaries for ANXA6 Gene

Entrez Gene Summary for ANXA6 Gene

  • Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

GeneCards Summary for ANXA6 Gene

ANXA6 (Annexin A6) is a Protein Coding gene. Diseases associated with ANXA6 include kwashiorkor and neonatal lupus erythematosus. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Prostaglandin Synthesis and Regulation. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA9.

UniProtKB/Swiss-Prot for ANXA6 Gene

  • May associate with CD21. May regulate the release of Ca(2+) from intracellular stores

Gene Wiki entry for ANXA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA6 Gene

Genomics for ANXA6 Gene

Regulatory Elements for ANXA6 Gene

Genomic Location for ANXA6 Gene

151,100,706 bp from pter
151,157,882 bp from pter
57,177 bases
Minus strand

Genomic View for ANXA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANXA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA6 Gene

Proteins for ANXA6 Gene

  • Protein details for ANXA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin A6
    Protein Accession:
    Secondary Accessions:
    • B7Z8A7
    • D3DQH4
    • E9PGK1
    • Q6ZT79

    Protein attributes for ANXA6 Gene

    673 amino acids
    Molecular mass:
    75873 Da
    Quaternary structure:
    No Data Available
    • Seems to bind one calcium ion with high affinity

    Three dimensional structures from OCA and Proteopedia for ANXA6 Gene

    Alternative splice isoforms for ANXA6 Gene


neXtProt entry for ANXA6 Gene

Proteomics data for ANXA6 Gene at MOPED

Post-translational modifications for ANXA6 Gene

  • Phosphorylated in response to growth factor stimulation
  • Ubiquitination at Lys9, Lys68, Lys81, Lys102, Lys135, Lys240, Lys377, Lys418, and Lys456
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ANXA6 Gene

Domains for ANXA6 Gene

Gene Families for ANXA6 Gene


Protein Domains for ANXA6 Gene

Suggested Antigen Peptide Sequences for ANXA6 Gene

Graphical View of Domain Structure for InterPro Entry



  • P08133
  • A pair of annexin repeats may form one binding site for calcium and phospholipid
  • Belongs to the annexin family.
  • Contains 8 annexin repeats.
genes like me logo Genes that share domains with ANXA6: view

Function for ANXA6 Gene

Molecular function for ANXA6 Gene

GENATLAS Biochemistry:
annexin A6,p68 calcium and phospholipid binding protein
UniProtKB/Swiss-Prot Function:
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores
UniProtKB/Swiss-Prot Induction:
By Epstein-Barr virus (EBV)

Gene Ontology (GO) - Molecular Function for ANXA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15576473
GO:0005525 GTP binding IMP 16605264
GO:0005544 calcium-dependent phospholipid binding IDA 2138016
GO:0008289 lipid binding IMP 16605264
genes like me logo Genes that share ontologies with ANXA6: view
genes like me logo Genes that share phenotypes with ANXA6: view

Animal Models for ANXA6 Gene

MGI Knock Outs for ANXA6:

miRNA for ANXA6 Gene

miRTarBase miRNAs that target ANXA6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANXA6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ANXA6 Gene

Localization for ANXA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA6 Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Jensen Localization Image for ANXA6 Gene COMPARTMENTS Subcellular localization image for ANXA6 gene
Compartment Confidence
extracellular 5
cytosol 3
cytoskeleton 2
endosome 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ANXA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 23360953
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
GO:0031902 late endosome membrane IDA 23360953
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with ANXA6: view

Pathways for ANXA6 Gene

genes like me logo Genes that share pathways with ANXA6: view

Pathways by source for ANXA6 Gene

Gene Ontology (GO) - Biological Process for ANXA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IEA --
GO:0006937 regulation of muscle contraction IEA --
GO:0034220 ion transmembrane transport IMP 16605264
GO:0051260 protein homooligomerization IMP 16605264
genes like me logo Genes that share ontologies with ANXA6: view

Compounds for ANXA6 Gene

(1) HMDB Compounds for ANXA6 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(21) Novoseek inferred chemical compound relationships for ANXA6 Gene

Compound -log(P) Hits PubMed IDs
phospholipid 54.8 21
phosphatidylserine 50.6 2
calcium 48.9 65
phosphatidylethanolamine 36.5 2
phosphatidylcholine 30.9 4
genes like me logo Genes that share compounds with ANXA6: view

Transcripts for ANXA6 Gene

Unigene Clusters for ANXA6 Gene

Annexin A6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANXA6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA6 Gene

No ASD Table

Relevant External Links for ANXA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA6 Gene

mRNA expression in normal human tissues for ANXA6 Gene

Protein differential expression in normal tissues for ANXA6 Gene

This gene is overexpressed in Lymph node (9.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA6 Gene

SOURCE GeneReport for Unigene cluster for ANXA6 Gene Hs.412117

genes like me logo Genes that share expressions with ANXA6: view

Expression partners for ANXA6 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANXA6 Gene

Orthologs for ANXA6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANXA6 35
  • 92.12 (n)
  • 94.8 (a)
ANXA6 36
  • 95 (a)
(Canis familiaris)
Mammalia ANXA6 35
  • 92.16 (n)
  • 96.13 (a)
ANXA6 36
  • 95 (a)
(Mus musculus)
Mammalia Anxa6 35
  • 89.4 (n)
  • 94.35 (a)
Anxa6 16
Anxa6 36
  • 94 (a)
(Pan troglodytes)
Mammalia ANXA6 35
  • 99.16 (n)
  • 98.81 (a)
(Rattus norvegicus)
Mammalia Anxa6 35
  • 89.05 (n)
  • 94.65 (a)
(Monodelphis domestica)
Mammalia ANXA6 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia ANXA6 36
  • 79 (a)
(Gallus gallus)
Aves ANXA6 35
  • 77.01 (n)
  • 79.01 (a)
ANXA6 36
  • 68 (a)
(Anolis carolinensis)
Reptilia ANXA6 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa6 35
  • 72.21 (n)
  • 77.21 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13585 35
(Danio rerio)
Actinopterygii anxa6 35
  • 68.89 (n)
  • 74.74 (a)
anxa6 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5307 35
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 37
  • 48 (a)
AnnX 37
  • 43 (a)
Anxb11 37
  • 46 (a)
AnnX 35
  • 55.91 (n)
  • 44.52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta ANXB10B 35
  • 55.99 (n)
  • 49.84 (a)
(Caenorhabditis elegans)
Secernentea nex-1 37
  • 40 (a)
nex-2 37
  • 47 (a)
nex-3 37
  • 37 (a)
nex-4 37
  • 29 (a)
Species with no ortholog for ANXA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA6 Gene

Gene Tree for ANXA6 (if available)
Gene Tree for ANXA6 (if available)

Paralogs for ANXA6 Gene

Paralogs for ANXA6 Gene

genes like me logo Genes that share paralogs with ANXA6: view

Variants for ANXA6 Gene

Sequence variations from dbSNP and Humsavar for ANXA6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs728052 -- 151,120,323(+) ATTGA(C/T)TGAAT intron-variant
rs745933 -- 151,143,798(-) TATTC(A/G)CAGTC intron-variant
rs745934 -- 151,144,170(-) CTTGC(A/C)CTTAC intron-variant
rs868531 -- 151,105,328(+) GATGC(A/G)GGGAA intron-variant
rs868641 -- 151,105,680(-) TCTGA(A/G)TCTTT intron-variant

Relevant External Links for ANXA6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANXA6 Gene

Disorders for ANXA6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ANXA6 Gene in MalaCards »

(3) Diseases for ANXA6 Gene including...

(14) Novoseek inferred disease relationships for ANXA6 Gene

Disease -log(P) Hits PubMed IDs
typhoid fever 11.1 1
cystic fibrosis 0.32 4
carcinoma squamous cell 0 2
necrosis 0 2
shock 0 4

Relevant External Links for ANXA6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ANXA6: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for ANXA6 Gene

Publications for ANXA6 Gene

  1. Structure and properties of calphobindin II, an anticoagulant protein from human placenta. (PMID: 2139657) Yoshizaki H. … Maki M. (J. Biochem. 1990) 3 4 23
  2. The structure of recombinant human annexin VI in crystals and membrane-bound. (PMID: 8709144) Benz J. … Voges D. (J. Mol. Biol. 1996) 3 4 23
  3. Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family. (PMID: 3258820) Crompton M.R. … Crumpton M.J. (EMBO J. 1988) 2 3 4
  4. Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro. (PMID: 19322030) Stogbauer F. … Buechler C. (Exp. Mol. Med. 2009) 3 23
  5. Plasma membrane-associated annexin A6 reduces Ca2+ entry by stabilizing the cortical actin cytoskeleton. (PMID: 19386597) Monastyrskaya K. … Draeger A. (J. Biol. Chem. 2009) 3 23

Products for ANXA6 Gene

  • Addgene plasmids for ANXA6

Sources for ANXA6 Gene

Back to Top