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Aliases for ANXA6 Gene

Aliases for ANXA6 Gene

  • Annexin A6 2 3 5
  • 67 KDa Calelectrin 3 4
  • Calphobindin-II 3 4
  • Chromobindin-20 3 4
  • Lipocortin VI 3 4
  • Annexin-6 3 4
  • CPB-II 3 4
  • ANX6 3 4
  • P68 3 4
  • P70 3 4
  • Testis Secretory Sperm-Binding Protein Li 198a 3
  • Calcium-Binding Protein P68 3
  • Annexin VI (P68) 3
  • Calphobindin II 3
  • Calelectrin 3
  • Protein III 4
  • Annexin VI 4
  • CBP68 3

External Ids for ANXA6 Gene

Previous HGNC Symbols for ANXA6 Gene

  • ANX6

Previous GeneCards Identifiers for ANXA6 Gene

  • GC05M150549
  • GC05M150463
  • GC05M150509
  • GC05M150460
  • GC05M145626

Summaries for ANXA6 Gene

Entrez Gene Summary for ANXA6 Gene

  • Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

GeneCards Summary for ANXA6 Gene

ANXA6 (Annexin A6) is a Protein Coding gene. Diseases associated with ANXA6 include Neonatal Lupus Erythematosus and Taeniasis. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Smooth Muscle Contraction. GO annotations related to this gene include calcium ion binding and GTP binding. An important paralog of this gene is ANXA4.

UniProtKB/Swiss-Prot for ANXA6 Gene

  • May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.

Gene Wiki entry for ANXA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA6 Gene

Genomics for ANXA6 Gene

Regulatory Elements for ANXA6 Gene

Enhancers for ANXA6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANXA6 on UCSC Golden Path with GeneCards custom track

Promoters for ANXA6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANXA6 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANXA6 Gene

151,100,706 bp from pter
151,157,882 bp from pter
57,177 bases
Minus strand

Genomic View for ANXA6 Gene

Genes around ANXA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA6 Gene

Proteins for ANXA6 Gene

  • Protein details for ANXA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin A6
    Protein Accession:
    Secondary Accessions:
    • B7Z8A7
    • D3DQH4
    • E9PGK1
    • Q6ZT79

    Protein attributes for ANXA6 Gene

    673 amino acids
    Molecular mass:
    75873 Da
    Quaternary structure:
    No Data Available
    • Seems to bind one calcium ion with high affinity.

    Three dimensional structures from OCA and Proteopedia for ANXA6 Gene

    Alternative splice isoforms for ANXA6 Gene


neXtProt entry for ANXA6 Gene

Proteomics data for ANXA6 Gene at MOPED

Post-translational modifications for ANXA6 Gene

  • Phosphorylated in response to growth factor stimulation.
  • Ubiquitination at Lys 9, Lys 68, Lys 81, Lys 102, Lys 135, Lys 240, Lys 377, and Lys 456
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANXA6 Gene

Domains & Families for ANXA6 Gene

Gene Families for ANXA6 Gene

Protein Domains for ANXA6 Gene

Suggested Antigen Peptide Sequences for ANXA6 Gene

Graphical View of Domain Structure for InterPro Entry



  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • Contains 8 annexin repeats.
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • Contains 8 annexin repeats.
genes like me logo Genes that share domains with ANXA6: view

Function for ANXA6 Gene

Molecular function for ANXA6 Gene

GENATLAS Biochemistry:
annexin A6,p68 calcium and phospholipid binding protein
UniProtKB/Swiss-Prot Function:
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
UniProtKB/Swiss-Prot Induction:
By Epstein-Barr virus (EBV).

Gene Ontology (GO) - Molecular Function for ANXA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IMP 16605264
GO:0008289 lipid binding IMP 16605264
genes like me logo Genes that share ontologies with ANXA6: view
genes like me logo Genes that share phenotypes with ANXA6: view

Animal Models for ANXA6 Gene

MGI Knock Outs for ANXA6:

Animal Model Products

miRNA for ANXA6 Gene

miRTarBase miRNAs that target ANXA6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANXA6 Gene

Localization for ANXA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA6 Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Jensen Localization Image for ANXA6 Gene COMPARTMENTS Subcellular localization image for ANXA6 gene
Compartment Confidence
endosome 5
extracellular 5
lysosome 5
vacuole 5
cytosol 4
nucleus 4
plasma membrane 4
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ANXA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005765 lysosomal membrane IDA 23360953
GO:0014704 intercalated disc IEA --
GO:0016020 membrane IDA 19946888
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with ANXA6: view

Pathways & Interactions for ANXA6 Gene

genes like me logo Genes that share pathways with ANXA6: view

Pathways by source for ANXA6 Gene

Gene Ontology (GO) - Biological Process for ANXA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034220 ion transmembrane transport IMP 16605264
GO:0097190 apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with ANXA6: view

No data available for SIGNOR curated interactions for ANXA6 Gene

Drugs & Compounds for ANXA6 Gene

(12) Drugs for ANXA6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(9) Additional Compounds for ANXA6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANXA6: view

Transcripts for ANXA6 Gene

Unigene Clusters for ANXA6 Gene

Annexin A6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA6 Gene

No ASD Table

Relevant External Links for ANXA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA6 Gene

mRNA expression in normal human tissues for ANXA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANXA6 Gene

This gene is overexpressed in Lymph node (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA6 Gene

SOURCE GeneReport for Unigene cluster for ANXA6 Gene Hs.412117

genes like me logo Genes that share expression patterns with ANXA6: view

Protein tissue co-expression partners for ANXA6 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANXA6 Gene

Orthologs for ANXA6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANXA6 35
  • 92.12 (n)
  • 94.8 (a)
ANXA6 36
  • 95 (a)
(Canis familiaris)
Mammalia ANXA6 35
  • 92.16 (n)
  • 96.13 (a)
ANXA6 36
  • 95 (a)
(Mus musculus)
Mammalia Anxa6 35
  • 89.4 (n)
  • 94.35 (a)
Anxa6 16
Anxa6 36
  • 94 (a)
(Pan troglodytes)
Mammalia ANXA6 35
  • 99.16 (n)
  • 98.81 (a)
(Rattus norvegicus)
Mammalia Anxa6 35
  • 89.05 (n)
  • 94.65 (a)
(Monodelphis domestica)
Mammalia ANXA6 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia ANXA6 36
  • 79 (a)
(Gallus gallus)
Aves ANXA6 35
  • 77.01 (n)
  • 79.01 (a)
ANXA6 36
  • 68 (a)
(Anolis carolinensis)
Reptilia ANXA6 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa6 35
  • 72.21 (n)
  • 77.21 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13585 35
(Danio rerio)
Actinopterygii anxa6 35
  • 68.89 (n)
  • 74.74 (a)
anxa6 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5307 35
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 37
  • 48 (a)
AnnX 37
  • 43 (a)
Anxb11 37
  • 46 (a)
AnnX 35
  • 55.91 (n)
  • 44.52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta ANXB10B 35
  • 55.99 (n)
  • 49.84 (a)
(Caenorhabditis elegans)
Secernentea nex-1 37
  • 40 (a)
nex-2 37
  • 47 (a)
nex-3 37
  • 37 (a)
nex-4 37
  • 29 (a)
Species with no ortholog for ANXA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA6 Gene

Gene Tree for ANXA6 (if available)
Gene Tree for ANXA6 (if available)

Paralogs for ANXA6 Gene

genes like me logo Genes that share paralogs with ANXA6: view

Variants for ANXA6 Gene

Sequence variations from dbSNP and Humsavar for ANXA6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs728052 -- 151,120,323(+) ATTGA(C/T)TGAAT intron-variant
rs745933 -- 151,143,798(-) TATTC(A/G)CAGTC intron-variant
rs745934 -- 151,144,170(-) CTTGC(A/C)CTTAC intron-variant
rs868531 -- 151,105,328(+) GATGC(A/G)GGGAA intron-variant
rs868641 -- 151,105,680(-) TCTGA(A/G)TCTTT intron-variant

Variation tolerance for ANXA6 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ANXA6 Gene

Disorders for ANXA6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANXA6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neonatal lupus erythematosus
  • neonatal systemic lupus erythematosus
  • beef tapeworm infection
papillary hidradenoma
- elite association - COSMIC cancer census association via MalaCards
Search ANXA6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ANXA6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ANXA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA6 Gene

Publications for ANXA6 Gene

  1. Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family. (PMID: 3258820) Crompton M.R. … Crumpton M.J. (EMBO J. 1988) 2 3 4 67
  2. Cholesterol as a factor regulating intracellular localization of annexin A6 in Niemann-Pick type C human skin fibroblasts. (PMID: 19900398) Sztolsztener M.E. … Bandorowicz-Pikula J. (Arch. Biochem. Biophys. 2010) 3 23
  3. Interaction of annexin A6 with cholesterol rich membranes is pH-dependent and mediated by the sterol OH. (PMID: 20363475) Domon M.M. … Besson F. (J Colloid Interface Sci 2010) 3 23
  4. Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro. (PMID: 19322030) Stogbauer F. … Buechler C. (Exp. Mol. Med. 2009) 3 23
  5. Plasma membrane-associated annexin A6 reduces Ca2+ entry by stabilizing the cortical actin cytoskeleton. (PMID: 19386597) Monastyrskaya K. … Draeger A. (J. Biol. Chem. 2009) 3 23

Products for ANXA6 Gene

Sources for ANXA6 Gene