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Aliases for ANXA5 Gene

Aliases for ANXA5 Gene

  • Annexin A5 2 3 5
  • Placental Anticoagulant Protein 4 3 4
  • Placental Anticoagulant Protein I 3 4
  • Vascular Anticoagulant-Alpha 3 4
  • Thromboplastin Inhibitor 3 4
  • Calphobindin I 3 4
  • Anchorin CII 3 4
  • Endonexin II 3 4
  • Lipocortin V 3 4
  • Annexin V 3 4
  • Annexin-5 3 4
  • VAC-Alpha 3 4
  • CBP-I 3 4
  • PAP-I 3 4
  • ANX5 3 4
  • ENX2 3 4
  • PP4 3 4
  • Epididymis Secretory Protein Li 7 3
  • HEL-S-7 3
  • RPRGL3 3

External Ids for ANXA5 Gene

Previous HGNC Symbols for ANXA5 Gene

  • ENX2
  • ANX5

Previous GeneCards Identifiers for ANXA5 Gene

  • GC04M123513
  • GC04M122868
  • GC04M122982
  • GC04M123047
  • GC04M122946
  • GC04M122589
  • GC04M118316

Summaries for ANXA5 Gene

Entrez Gene Summary for ANXA5 Gene

  • The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA5 Gene

ANXA5 (Annexin A5) is a Protein Coding gene. Diseases associated with ANXA5 include pregnancy loss, recurrent 3 and pregnancy loss, recurrent, susceptibility 3. Among its related pathways are Ca, cAMP and Lipid Signaling and Regulation of CFTR activity (norm and CF). GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA4.

UniProtKB/Swiss-Prot for ANXA5 Gene

  • This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Gene Wiki entry for ANXA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA5 Gene

Genomics for ANXA5 Gene

Regulatory Elements for ANXA5 Gene

Enhancers for ANXA5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANXA5 on UCSC Golden Path with GeneCards custom track

Promoters for ANXA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANXA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANXA5 Gene

Chromosome:
4
Start:
121,667,955 bp from pter
End:
121,697,113 bp from pter
Size:
29,159 bases
Orientation:
Minus strand

Genomic View for ANXA5 Gene

Genes around ANXA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA5 Gene

Proteins for ANXA5 Gene

  • Protein details for ANXA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08758-ANXA5_HUMAN
    Recommended name:
    Annexin A5
    Protein Accession:
    P08758
    Secondary Accessions:
    • D3DNW7
    • Q6FHB3
    • Q6FI16
    • Q8WV69
    • Q9UDH9

    Protein attributes for ANXA5 Gene

    Size:
    320 amino acids
    Molecular mass:
    35937 Da
    Quaternary structure:
    • Monomer. Binds ATRX and EIF5B (By similarity). Interacts with hepatitis B virus (HBV).

    Three dimensional structures from OCA and Proteopedia for ANXA5 Gene

neXtProt entry for ANXA5 Gene

Proteomics data for ANXA5 Gene at MOPED

Post-translational modifications for ANXA5 Gene

  • S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
  • Ubiquitination at Lys 29, Lys 76, Lys 79, Lys 108, Lys 193, Lys 290, and Lys 301
  • Modification sites at PhosphoSitePlus

Other Protein References for ANXA5 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANXA5 (ANXA5)

No data available for DME Specific Peptides for ANXA5 Gene

Domains & Families for ANXA5 Gene

Gene Families for ANXA5 Gene

Protein Domains for ANXA5 Gene

Suggested Antigen Peptide Sequences for ANXA5 Gene

Graphical View of Domain Structure for InterPro Entry

P08758

UniProtKB/Swiss-Prot:

ANXA5_HUMAN :
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
Domain:
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
Similarity:
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA5: view

Function for ANXA5 Gene

Molecular function for ANXA5 Gene

GENATLAS Biochemistry:
annexin A5,calcium and phospholipid binding protein,endonexin 2,placental protein 4,anchorin CII collagen receptor of chondrocytes,predominantly expressed in major constituent of growth plate chondrocytes,down-regulated in adult articular cartilage
UniProtKB/Swiss-Prot Function:
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
genes like me logo Genes that share phenotypes with ANXA5: view

Animal Models for ANXA5 Gene

MGI Knock Outs for ANXA5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANXA5 Gene

Localization for ANXA5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA5 Gene COMPARTMENTS Subcellular localization image for ANXA5 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 4
endoplasmic reticulum 3
mitochondrion 3
cytoskeleton 2
lysosome 2
vacuole 2
endosome 1

Gene Ontology (GO) - Cellular Components for ANXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IEA,TAS 16130169
GO:0005783 endoplasmic reticulum IEA --
GO:0008021 synaptic vesicle IEA --
GO:0014704 intercalated disc IEA --
genes like me logo Genes that share ontologies with ANXA5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA5 Gene

Pathways & Interactions for ANXA5 Gene

genes like me logo Genes that share pathways with ANXA5: view

Pathways by source for ANXA5 Gene

1 Cell Signaling Technology pathway for ANXA5 Gene
1 BioSystems pathway for ANXA5 Gene
1 GeneGo (Thomson Reuters) pathway for ANXA5 Gene

Gene Ontology (GO) - Biological Process for ANXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0043066 negative regulation of apoptotic process TAS 16130169
GO:0071284 cellular response to lead ion IEA --
GO:0097211 cellular response to gonadotropin-releasing hormone IEA --
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with ANXA5: view

No data available for SIGNOR curated interactions for ANXA5 Gene

Drugs & Compounds for ANXA5 Gene

(75) Drugs for ANXA5 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Experimental Pharma Target 0
1,4-Dideoxy-O2-Sulfo-Glucuronic Acid Experimental Pharma Target 0
K201 Experimental Pharma Target 0
L-Alpha-Glycerophosphorylethanolamine Experimental Pharma Target 0
L-Alpha-Glycerophosphorylserine Experimental Pharma Target 0

(82) Additional Compounds for ANXA5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANXA5: view

Transcripts for ANXA5 Gene

Unigene Clusters for ANXA5 Gene

Annexin A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7:
SP8: - - - - - - - - - - -
SP9: - -

Relevant External Links for ANXA5 Gene

GeneLoc Exon Structure for
ANXA5
ECgene alternative splicing isoforms for
ANXA5

Expression for ANXA5 Gene

mRNA expression in normal human tissues for ANXA5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA5 Gene



SOURCE GeneReport for Unigene cluster for ANXA5 Gene Hs.480653

genes like me logo Genes that share expression patterns with ANXA5: view

Protein tissue co-expression partners for ANXA5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANXA5 Gene

Orthologs for ANXA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANXA5 35
  • 92.08 (n)
  • 96.56 (a)
ANXA5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA5 35
  • 93.44 (n)
  • 97.19 (a)
ANXA5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa5 35
  • 86.98 (n)
  • 93.65 (a)
Anxa5 16
Anxa5 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANXA5 35
  • 99.79 (n)
  • 100 (a)
ANXA5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa5 35
  • 85.44 (n)
  • 91.77 (a)
oppossum
(Monodelphis domestica)
Mammalia ANXA5 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANXA5 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANXA5 35
  • 74.9 (n)
  • 78.44 (a)
ANXA5 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA5 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa5 35
  • 72.59 (n)
  • 74.6 (a)
Str.8395 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398472 35
zebrafish
(Danio rerio)
Actinopterygii anxa5b 35
  • 62.19 (n)
  • 64.86 (a)
anxa5a 36
  • 59 (a)
OneToMany
anxa5b 36
  • 64 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9774 35
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 37
  • 48 (a)
AnnX 37
  • 46 (a)
Anxb11 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea nex-1 37
  • 39 (a)
nex-2 37
  • 46 (a)
nex-3 37
  • 38 (a)
Species with no ortholog for ANXA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA5 Gene

ENSEMBL:
Gene Tree for ANXA5 (if available)
TreeFam:
Gene Tree for ANXA5 (if available)

Paralogs for ANXA5 Gene

genes like me logo Genes that share paralogs with ANXA5: view

Variants for ANXA5 Gene

Sequence variations from dbSNP and Humsavar for ANXA5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs9611 -- 121,668,041(-) TGATT(A/G)TATTC utr-variant-3-prime
rs17718 -- 121,668,128(-) TTAAT(C/T)AGAAG utr-variant-3-prime
rs1131239 -- 121,696,590(-) GTCGC(A/C/G/T)ATGGC utr-variant-5-prime
rs1383232 -- 121,691,268(-) AGCCA(A/G)CAAAA intron-variant
rs1050606 -- 121,696,891(-) CGGGG(G/T)TTCGG utr-variant-5-prime

Variation tolerance for ANXA5 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANXA5 Gene

HapMap Linkage Disequilibrium report
ANXA5
Human Gene Mutation Database (HGMD)
ANXA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANXA5 Gene

Disorders for ANXA5 Gene

MalaCards: The human disease database

(30) MalaCards diseases for ANXA5 Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pregnancy loss, recurrent 3
  • pregnancy loss, recurrent, susceptibility to, 3
pregnancy loss, recurrent, susceptibility 3
antiphospholipid syndrome
  • antiphospholipid antibody syndrome
indolent myeloma
  • indolent multiple myeloma
head and neck carcinoma
  • carcinoma of neck
- elite association - COSMIC cancer census association via MalaCards
Search ANXA5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ANXA5_HUMAN
  • Pregnancy loss, recurrent, 3 (RPRGL3) [MIM:614391]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. {ECO:0000269 PubMed:17339269}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for ANXA5

Genetic Association Database (GAD)
ANXA5
Human Genome Epidemiology (HuGE) Navigator
ANXA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANXA5
genes like me logo Genes that share disorders with ANXA5: view

No data available for Genatlas for ANXA5 Gene

Publications for ANXA5 Gene

  1. A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss. (PMID: 17339269) Bogdanova N. … Markoff A. (Hum. Mol. Genet. 2007) 3 4 48 67
  2. Annexin A5 is involved in migration and invasion of oral carcinoma. (PMID: 19372761) Wehder L. … Melle C. (Cell Cycle 2009) 3 23
  3. Group B Streptococcus induces tyrosine phosphorylation of annexin V and glutathione S-transferase in human umbilical vein endothelial cells. (PMID: 19639233) Santos G.S. … Nagao P.E. (Int. J. Mol. Med. 2009) 3 23
  4. Plasma annexin A5 and microparticle phosphatidylserine levels are elevated in sickle cell disease and increase further during painful crisis. (PMID: 19799864) van Tits L.J. … Schnog J.B. (Biochem. Biophys. Res. Commun. 2009) 3 23
  5. Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. (PMID: 19810772) Bedrood S. … Ritzel R.A. (Biochemistry 2009) 3 23

Products for ANXA5 Gene

Sources for ANXA5 Gene

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