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ANXA5 Gene

protein-coding   GIFtS: 71
GCID: GC04M122589

Annexin A5


(Previous symbols: ENX2, ANX5)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Annexin A51 2     Vascular Anticoagulant-Alpha2 3
ENX21 2 3 5     CBP-I2 3
ANX51 2 3     PAP-I2 3
Anchorin CII2 3     PP42 3
Annexin V2 3     VAC-alpha2 3
Calphobindin I2 3     RPRGL32 5
Endonexin II2 3     HEL-S-72
Lipocortin V2 3     annexin-52
Placental Anticoagulant Protein 42 3     Epididymis Secretory Protein Li 72
Placental Anticoagulant Protein I2 3     Annexin-53
Thromboplastin Inhibitor2 3     

External Ids:    HGNC: 5431   Entrez Gene: 3082   Ensembl: ENSG000001641117   OMIM: 1312305   UniProtKB: P087583   

Export aliases for ANXA5 gene to outside databases

Previous GC identifers: GC04M123513 GC04M122868 GC04M122982 GC04M123047 GC04M122946 GC04M118316


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANXA5 Gene:
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins
some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin
5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential
role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described
as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein
4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately
1.6 kb and a protein product with a molecular weight of about 35 kDa. (provided by RefSeq, Jul 2008)

GeneCards Summary for ANXA5 Gene:
ANXA5 (annexin A5) is a protein-coding gene. Diseases associated with ANXA5 include pregnancy loss, recurrent 3, and cluttering. GO annotations related to this gene include calcium-dependent phospholipid binding and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANXA5_HUMAN, P08758
Function: This protein is an anticoagulant protein that acts as an indirect inhibitor of the
thromboplastin-specific complex, which is involved in the blood coagulation cascade

Gene Wiki entry for ANXA5 (Annexin A5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANXA5 gene promoter:
         GR   CREB   HNF-1   deltaCREB   GR-alpha   HNF-1A   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANXA5 promoter sequence
   Search Chromatin IP Primers for ANXA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANXA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q27   Ensembl cytogenetic band:  4q27   HGNC cytogenetic band: 4q27

ANXA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M122589:  view genomic region     (about GC identifiers)

Start:
122,589,110 bp from pter      End:
122,618,268 bp from pter
Size:
29,159 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ANXA5_HUMAN, P08758 (See protein sequence)
Recommended Name: Annexin A5  
Size: 320 amino acids; 35937 Da
Subunit: Monomer. Binds ATRX and EIF5B (By similarity). Interacts with hepatitis B virus (HBV)
Selected PDB 3D structures from and Proteopedia for ANXA5 (see all 12):
1ANW (3D)        1ANX (3D)        1AVH (3D)        1AVR (3D)        1HAK (3D)        1HVD (3D)    
Secondary accessions: D3DNW7 Q6FHB3 Q6FI16 Q8WV69 Q9UDH9

Explore the universe of human proteins at neXtProt for ANXA5: NX_P08758

Explore proteomics data for ANXA5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys29, Lys58, Lys76, Lys79, Lys86, Lys97, Lys108, Lys193, Lys290, Lys301
  • Modification sites at PhosphoSitePlus

  • See ANXA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001145.1  
    ENSEMBL proteins: 
     ENSP00000296511   ENSP00000424106   ENSP00000421421   ENSP00000424199   ENSP00000427135  

    ANXA5 Human Recombinant Protein Products:

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    Enzo Life Sciences proteins for ANXA5
    OriGene Purified Proteins for ANXA5
    OriGene Protein Over-expression Lysate for ANXA5
    OriGene MassSpec for ANXA5
    OriGene Custom Protein Services for ANXA5
    GenScript Custom Purified and Recombinant Proteins Services for ANXA5
    Novus Biologicals ANXA5 Proteins
    Novus Biologicals ANXA5 Lysates
    Sino Biological Recombinant Protein for ANXA5
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ANXA5
    Cloud-Clone Corp. Proteins for ANXA5

    ANXA5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ANXA5 (Annexin V)
    Cell Signaling Technology (CST) Antibodies for ANXA5 
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    OriGene Custom Antibody Services for ANXA5
    Novus Biologicals ANXA5 Antibodies
    Abcam antibodies for ANXA5
    Cloud-Clone Corp. Antibodies for ANXA5
    ThermoFisher Antibody for ANXA5
    LSBio Antibodies in human, mouse, rat for ANXA5

    ANXA5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Apoptosis Detection Kits & Reagents for ANXA5 (Annexin V)         (see all)
    GenScript Custom Assay Services for ANXA5
    Enzo Life Sciences assays for ANXA5
    Cloud-Clone Corp. ELISAs for ANXA5
    Cloud-Clone Corp. CLIAs for ANXA5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANXA: Annexins

    5 InterPro protein domains:
     IPR002392 AnnexinV
     IPR018502 Annexin_repeat
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR015473 Annexins_V

    Graphical View of Domain Structure for InterPro Entry P08758

    ProtoNet protein and cluster: P08758

    2 Blocks protein domains:
    IPB001464 Annexin
    IPB002392 Annexin type V signature


    UniProtKB/Swiss-Prot: ANXA5_HUMAN, P08758
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    ANXA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANXA5_HUMAN, P08758
    Function: This protein is an anticoagulant protein that acts as an indirect inhibitor of the
    thromboplastin-specific complex, which is involved in the blood coagulation cascade

         Genatlas biochemistry entry for ANXA5:
    annexin A5,calcium and phospholipid binding protein,endonexin 2,placental protein 4,anchorin CII collagen receptor
    of chondrocytes,predominantly expressed in major constituent of growth plate chondrocytes,down-regulated in adult
    articular cartilage

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity TAS2967495
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding TAS2967291
    GO:0005544calcium-dependent phospholipid binding IDA2138016
         
    ANXA5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ANXA5:
     Increased cell number in G2M,   Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Anxa5):
     immune system  normal 

    ANXA5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANXA5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANXA5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANXA5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANXA5

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANXA5:
    hsa-mir-124-3p (MIRT022801), hsa-mir-330-5p (MIRT038248), hsa-mir-26b-5p (MIRT029721)

    Block miRNA regulation of human, mouse, rat ANXA5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ANXA5:
    hsa-miR-3910 hsa-miR-124 hsa-miR-3146 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidANXA5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANXA5
    Predesigned siRNA for gene silencing in human, mouse, rat ANXA5

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ANXA5

    Clone
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    OriGene ORF clones in mouse, rat for ANXA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANXA5 (NM_001154)
    Sino Biological Human cDNA Clone for ANXA5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA5

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ANXA5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol3
    mitochondrion3
    nucleus3
    plasma membrane3
    cytoskeleton2
    endoplasmic reticulum2
    vacuole2
    lysosome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm TAS16130169
    GO:0009897external side of plasma membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867
    GO:0072563endothelial microparticle IEA--

    ANXA5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANXA5 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of CFTR activity norm and CF
    Regulation of CFTR activity norm and CF 0.38
    2Prostaglandin Synthesis and Regulation
    Prostaglandin Synthesis and Regulation
    3Calcium channels
    Calcium channels
    4Ca, cAMP and Lipid Signaling
    Ca, cAMP and Lipid Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ANXA5
        Ca, cAMP and Lipid Signaling

    1 GeneGo (Thomson Reuters) Pathway for ANXA5
        Regulation of CFTR activity (norm and CF)

    1 BioSystems Pathway for ANXA5
        Prostaglandin Synthesis and Regulation




    ANXA5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ANXA5 (see all 6): 
              Osteogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Lung Cancer in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANXA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANXA5 (P087582, 3 ENSP000002965114) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FDFT1P372682, 3MINT-63431 I2D: score=5 
    SUPT4H1P632722, 3, ENSP000002255044MINT-64710 I2D: score=4 STRING: ENSP00000225504
    IFNGR2P384843, ENSP000002902194I2D: score=3 STRING: ENSP00000290219
    ITGB5P180843, ENSP000002961814I2D: score=3 STRING: ENSP00000296181
    PPP2R1BP301543, ENSP000003113444I2D: score=3 STRING: ENSP00000311344
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS16130169
    GO:0007596blood coagulation IEA--
    GO:0010033response to organic substance IEA--
    GO:0043066negative regulation of apoptotic process TAS16130169
    GO:0043086negative regulation of catalytic activity TAS2967495

    ANXA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANXA5

    1 HMDB Compound for ANXA5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 DrugBank Compounds for ANXA5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid-- --target--17139284 17016423 10592235
    1,4-Dideoxy-O2-Sulfo-Glucuronic Acid-- --target--17139284 17016423 10592235
    L-Alpha-Glycerophosphorylethanolamine-- --target--17139284 17016423 10592235
    L-Alpha-Glycerophosphorylserine-- --target--17139284 17016423 10592235
    N,O6-Disulfo-Glucosamine-- --target--17139284 17016423 10592235
    Thioproline-- 2756-91-4target--17139284 17016423 10592235
    K201-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for ANXA5 gene (see all 150)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylserine 93.2 743 18954406 (6), 16887494 (5), 19799864 (5), 9201968 (5) (see all 99)
    7-aminoactinomycin d 81.1 65 18094537 (4), 16510434 (3), 20436221 (2), 17542025 (1) (see all 35)
    phospholipid 75.4 283 11314866 (6), 9716593 (5), 9555096 (5), 9845435 (5) (see all 99)
    fluo 3 74.4 10 17975305 (1), 18340638 (1), 17180616 (1), 19320779 (1) (see all 10)
    3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 72.9 18 19550420 (1), 15476283 (1), 18595131 (1), 19233258 (1) (see all 17)
    propidium 66.8 17 9446752 (1), 17264311 (1), 11527959 (1), 15994859 (1) (see all 16)
    adpribose 63.9 18 17530784 (1), 19910795 (1), 9878595 (1), 15346059 (1) (see all 18)
    dutp 62.4 41 11435891 (2), 19846818 (2), 12840208 (1), 15241357 (1) (see all 36)
    fitc 59.6 30 16887494 (2), 19181273 (2), 7622868 (1), 9935075 (1) (see all 21)
    hoechst 33342 58.1 19 14636005 (1), 15809743 (1), 19056458 (1), 18723272 (1) (see all 19)



    ANXA5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANXA5 gene: 
    NM_001154.3  

    Unigene Cluster for ANXA5:

    Annexin A5
    Hs.480653  [show with all ESTs]
    Unigene Representative Sequence: NM_001154
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296511(uc003idu.4 uc003idv.4) ENST00000501272 ENST00000506395
    ENST00000515017 ENST00000509648 ENST00000515717 ENST00000511552 ENST00000509016
    ENST00000513428 ENST00000513523 ENST00000513728
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ANXA5:
    hsa-miR-3910 hsa-miR-124 hsa-miR-3146 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidANXA5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANXA5
    Clone
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    GenScript: all cDNA clones in your preferred vector: ANXA5 (NM_001154)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA5
    Primer
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    OriGene qPCR primer pairs and template standards for ANXA5
    OriGene qSTAR qPCR primer pairs in human, mouse for ANXA5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANXA5
      QuantiTect SYBR Green Assays in human, mouse, rat ANXA5
      QuantiFast Probe-based Assays in human, mouse, rat ANXA5

    Additional mRNA sequence: 

    AK297909.1 AK312644.1 AY577779.1 BC001429.2 BC004993.1 BC012804.2 BC012822.2 BC018671.1 
    BC032093.1 CR536522.1 CR541842.1 D00172.1 J03745.1 M18366.1 M19384.1 M21731.1 
    X12454.1 

    Selected DOTS entries (see all 37):

    DT.419426  DT.92459023  DT.452201  DT.97860528  DT.100888053  DT.100888084  DT.100888066  DT.100888067 
    DT.121247753  DT.100888078  DT.95205169  DT.121247757  DT.100888069  DT.92392218  DT.100888055  DT.100888085 
    DT.121247674  DT.121247729  DT.40116840  DT.100888056  DT.100888057  DT.100888072  DT.100888086  DT.100888093 

    Selected AceView cDNA sequences (see all 966):

    H88158 CR594878 CR596501 CR596570 BX417846 CR596264 AA320739 AI093038 
    BG120711 BG676850 BQ721320 CR608412 AW513785 CR607473 BX381687 CA420756 
    F27323 CA449115 BQ548795 BX337553 BQ723652 CD678235 AA381429 CB137538 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANXA5 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:              -                                                                       -     -                                                   
    SP2:                                                                                      -     -                                                   
    SP3:              -                                                                             -                                                   
    SP4:              -                                               -     -                 -     -                                                   
    SP5:              -                 -     -                                                                                                         


    ECgene alternative splicing isoforms for ANXA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANXA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACTTTAAT
    ANXA5 Expression
    About this image


    ANXA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    ANXA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANXA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.480653
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ANXA5 (see all 6): 
              Osteogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Lung Cancer in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ANXA5 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anxa51 , 5 annexin A51, 5 86.98(n)1
    93.65(a)1
      3 (17.46 cM)5
    117471  NM_009673.21  NP_033803.11 
     364489255 
    chicken
    (Gallus gallus)
    Aves ANXA51 annexin A5 74.9(n)
    78.44(a)
      428767  NM_001031538.1  NP_001026709.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA56
    annexin A5
    79(a)
    1 ↔ 1
    5(139121488-139155748)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3984722 hypothetical protein LOC398472 77.68(n)    BC054175.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anxa5b1 annexin A5b 62.19(n)
    64.86(a)
      337132  NM_181757.2  NP_861422.2 


    ENSEMBL Gene Tree for ANXA5 (if available)
    TreeFam Gene Tree for ANXA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANXA5 gene
    ANXA32  ANXA62  ANXA12  ANXA92  ANXA22  ANXA72  ANXA82  ANXA112  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA5 using alignment to 6 protein entries:     ANXA5_HUMAN (see all proteins):
    DKFZp686H02120    ANXA4    ANXA6    ANXA11    ANXA8L2    ANXA2P2
    ANXA3    ANXA7    ANXA13    ANXA10    ANXA8    ANXA2
    ANXA1    ANXA8L1    ANXA9

    ANXA5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANXA5 (see all 676)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs715991531,2
    C--118317735(+) AAAAA-/AGAGAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1136776881,2
    F--118317751(+) AAAAAGA/-GAGAA 1 -- int12Minor allele frequency- -:0.50CSA 4
    rs106800991,2
    C--118327034(+) CATCACTC/-CTCCT 1 -- cds11Minor allele frequency- -:0.50NA 2
    rs715991551,2
    C--118334148(+) TTTGCTT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs346743391,2
    C,F--118338085(+) GGCTTG/-GTGAG 1 -- int14Minor allele frequency- -:0.38NA 8
    rs131215881,2
    C,F--118338387(+) AGGACC/TTTGGC 1 -- int13Minor allele frequency- T:0.50WA NA 6
    rs131488621,2
    C,F--118338388(+) GGACCC/TTGGCT 1 -- int13Minor allele frequency- T:0.33WA NA 6
    rs719524271,2
    C--118339295(+) TTATA-/ATATA 
            
    TTCTT
    1 -- int10--------
    rs2005022531,2
    C--118339444(+) ATGCCA/CAAAAA 1 -- int10--------
    rs1889201451,2
    --122374224(+) AGATCA/GATAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ANXA5 (122589110 - 122618268 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ANXA5: --
    Human Gene Mutation Database (HGMD): ANXA5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANXA5
    DNA2.0 Custom Variant and Variant Library Synthesis for ANXA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 131230   
    OMIM disorders: 614391  
    UniProtKB/Swiss-Prot: ANXA5_HUMAN, P08758
  • Pregnancy loss, recurrent, 3 (RPRGL3) [MIM:614391]: A common complication of pregnancy, resulting in
    spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of
    conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous
    abortions. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • Selected diseases for ANXA5 (see all 179):    
    About MalaCards
    pregnancy loss, recurrent 3    cluttering    pregnancy loss    amelanotic melanoma
    t-lymphocytopenia    pyruvate kinase deficiency    multiple endocrine neoplasia type 2a    arteriosclerosis obliterans
    antiphospholipid syndrome    barth syndrome    transposition of the great arteries    hypertensive heart disease
    syphilis    adult-onset still's disease    ocular melanoma    beta thalassemia
    lymphopenia    glanders    thrombophilia    megakaryocytic leukemia

    13 diseases from the University of Copenhagen DISEASES database for ANXA5:
    Leukemia     Antiphospholipid syndrome     Vascular disease     Carcinoma
    Lupus erythematosus     Multiple myeloma     Hepatocellular carcinoma     Lymphoma
    Lung cancer     Connective tissue disease     Melanoma     Breast cancer
    Heart disease

    ANXA5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ANXA5 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 68.4 115 16246359 (2), 11437072 (1), 11904623 (1), 15192332 (1) (see all 99)
    antiphospholipid syndrome 64.2 35 10411817 (5), 11123066 (3), 10844535 (2), 16449315 (2) (see all 23)
    tumors 58.4 65 19663783 (3), 16222122 (3), 14750890 (2), 19461527 (2) (see all 52)
    cancer 56.3 26 15662629 (1), 18345031 (1), 18726985 (1), 15827335 (1) (see all 23)
    promyelocytic leukemia 52.4 3 10520199 (1), 19222854 (1)
    leukemia 50.8 14 9720729 (2), 17541033 (1), 18487508 (1), 9535035 (1) (see all 13)
    lupus erythematosus systemic 45.7 9 19764414 (1), 11375285 (1), 15628909 (1), 15539620 (1) (see all 9)
    cell damage 45.6 12 16869796 (2), 11168945 (1), 11729237 (1), 15843896 (1) (see all 9)
    pregnancy loss 44.8 11 11123066 (2), 17236406 (2), 9411225 (1), 15628909 (1) (see all 9)
    myeloma 44.3 18 16368890 (1), 17323615 (1), 9531328 (1), 10930529 (1) (see all 13)

    Genetic Association Database (GAD): ANXA5
    Human Genome Epidemiology (HuGE) Navigator: ANXA5 (16 documents)

    Export disorders for ANXA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANXA5 gene, integrated from 10 sources (see all 1720):
    (articles sorted by number of sources associating them with ANXA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss. (PubMed id 17339269)1, 2, 4, 9 Bogdanova N....Markoff A. (Hum. Mol. Genet. 2007)
    2. The gene encoding human annexin V has a TATA-less promoter with a high G+C content. (PubMed id 7958998)1, 2, 9 Fernandez M.-P.... Carcedo M.-T. (Gene 1994)
    3. Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor. (PubMed id 9398511)1, 2, 9 Kaneko N.... Miyano M. (J. Mol. Biol. 1997)
    4. The calcium binding sites in human annexin V by crystal structure analysis at 2.0-A resolution. Implications for membrane binding and calcium channel activity. (PubMed id 2148156)1, 2, 9 Huber R.... Paques E.-P. (FEBS Lett. 1990)
    5. Matrix metalloproteinase-9 gene -1562C/T polymorphism mitigates preeclampsia. (PubMed id 17137622)1, 4, 9 Coolman M....de Groot C.J. (Placenta 2007)
    6. Annexin A5 polymorphism (-1C--&gt;T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome. (PubMed id 16449315)1, 4, 9 de Laat B....van Heerde W.L. (Ann. Rheum. Dis. 2006)
    7. The crystal and molecular structure of human annexin V, an anticoagulant protein that binds to calcium and membranes. (PubMed id 2147412)1, 2, 9 Huber R.... Paques E.-P. (EMBO J. 1990)
    8. Organization of the human annexin V (ANX5) gene. (PubMed id 8034319)1, 2, 9 Cookson B.T....Tait J.F. (Genomics 1994)
    9. Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins. (PubMed id 1311770)1, 2, 9 Huber R.... Paques E.-P. (J. Mol. Biol. 1992)
    10. Genome-wide association study of smoking behaviours in patients with COPD. (PubMed id 21685187)1, 4 Siedlinski M.... . (Thorax 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 308 HGNC: 543 AceView: ANXA5 Ensembl:ENSG00000164111 euGenes: HUgn308
    ECgene: ANXA5 H-InvDB: ANXA5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANXA5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANXA5 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine source book: Annexin Vhttp://www.rndsystems.com/molecule_detail.aspx?m=1063

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANXA5 gene:
    Search GeneIP for patents involving ANXA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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