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ANXA4 Gene

protein-coding   GIFtS: 66
GCID: GC02P069872

Annexin A4


(Previous symbol: ANX4)
  See ANXA4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Annexin A41 2     PIG282
ANX41 2 3 5     ZAP362
Carbohydrate-Binding Protein P33/P412 3     Annexin IV (Placental Anticoagulant Protein II)2
Endonexin I2 3     annexin-42
Lipocortin IV2 3     chromobindin-42
Placental Anticoagulant Protein II2 3     Epididymis Secretory Protein Li 2742
Protein II2 3     Proliferation-Inducing Gene 282
35-Beta Calcimedin2 3     Proliferation-Inducing Protein 282
P32.52 3     Annexin-43
PAP-II2 3     Chromobindin-43
PP4-X2 3     Annexin IV3
HEL-S-2742     

External Ids:    HGNC: 5421   Entrez Gene: 3072   Ensembl: ENSG000001969757   OMIM: 1064915   UniProtKB: P095253   

Export aliases for ANXA4 gene to outside databases

Previous GC identifers: GC02P070018 GC02P070180 GC02P069926 GC02P069943 GC02P069880 GC02P069947 GC02P069705


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANXA4 Gene:
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their
functions are still not clearly defined, several members of the annexin family have been implicated in
membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members
of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes
a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits
phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. (provided by RefSeq, Jul
2008)

GeneCards Summary for ANXA4 Gene:
ANXA4 (annexin A4) is a protein-coding gene. Diseases associated with ANXA4 include papillary serous adenocarcinoma, and legionnaires' disease. GO annotations related to this gene include phospholipase inhibitor activity and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANXA4_HUMAN, P09525
Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis (By
similarity)

Gene Wiki entry for ANXA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANXA4 gene promoter:
         HOXA9B   HOXA9   Max1   NCX/Ncx   HSF1 (long)   C/EBPalpha   HSF1short   Meis-1a   c-Myc   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ANXA4 promoter sequence
   Search Chromatin IP Primers for ANXA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANXA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13.3

ANXA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P069872:  view genomic region     (about GC identifiers)

Start:
69,871,557 bp from pter      End:
70,053,596 bp from pter
Size:
182,040 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANXA4_HUMAN, P09525 (See protein sequence)
Recommended Name: Annexin A4  
Size: 319 amino acids; 35883 Da
Miscellaneous: Seems to bind one calcium ion with high affinity
Sequence caution: Sequence=AAC41689.1; Type=Erroneous initiation; Sequence=AAH00182.1; Type=Erroneous initiation;
Sequence=AAH11659.1; Type=Erroneous initiation; Sequence=BAA11227.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ANXA4:
2ZOC (3D)    
Secondary accessions: Q96F33 Q9BWK1

Explore the universe of human proteins at neXtProt for ANXA4: NX_P09525

Explore proteomics data for ANXA4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys293
  • Modification sites at PhosphoSitePlus

  • See ANXA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001144.1  
    ENSEMBL proteins: 
     ENSP00000386756   ENSP00000377833   ENSP00000441931  

    ANXA4 Human Recombinant Protein Products:

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    Novus Biologicals ANXA4 Proteins
    Novus Biologicals ANXA4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ANXA4
    Cloud-Clone Corp. Proteins for ANXA4

     
    Search eBioscience for Proteins for ANXA4 

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    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse Kits and Assays available from EMD Millipore
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    Search eBioscience for ELISAs for ANXA4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANXA: Annexins

    4 InterPro protein domains:
     IPR002391 AnnexinIV
     IPR018502 Annexin_repeat
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS

    Graphical View of Domain Structure for InterPro Entry P09525

    ProtoNet protein and cluster: P09525

    2 Blocks protein domains:
    IPB001464 Annexin
    IPB002391 Annexin type IV signature


    UniProtKB/Swiss-Prot: ANXA4_HUMAN, P09525
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    Find genes that share domains with ANXA4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANXA4_HUMAN, P09525
    Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis (By
    similarity)

         Genatlas biochemistry entry for ANXA4:
    annexin A4,calcium and phospholipid binding protein,calcimedin 35 beta,chromobindin 4,endonexin 1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity NAS2970257
    GO:0005509calcium ion binding IEA--
    GO:0005544calcium-dependent phospholipid binding NAS2970257
         
    Find genes that share ontologies with ANXA4           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ANXA4:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Lamellipodia cells 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Anxa4):
     behavior/neurological  renal/urinary system 

    Find genes that share phenotypes with ANXA4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANXA4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANXA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANXA4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANXA4

    miRNA
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    miRTarBase miRNAs that target ANXA4:
    hsa-mir-34a-5p (MIRT025331)

    Block miRNA regulation of human, mouse, rat ANXA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANXA4 (see all 22):
    hsa-miR-3673 hsa-miR-607 hsa-miR-488 hsa-miR-650 hsa-miR-374c hsa-miR-124 hsa-miR-641 hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidANXA4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ANXA4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ANXA4 (NM_001153)
    Sino Biological Human cDNA Clone for ANXA4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ANXA4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS16130169
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ANXA4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANXA4 About    
    See pathways by source

    SuperPathContained pathways About
    1Prostaglandin Synthesis and Regulation
    Prostaglandin Synthesis and Regulation


    1 BioSystems Pathway for ANXA4
        Prostaglandin Synthesis and Regulation



        Pathway & Disease-focused RT2 Profiler PCR Array including ANXA4: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANXA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANXA4 (P095252, 3 ENSP000003778334) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NMT2O605512, 3, ENSP000003674074MINT-8247899 I2D: score=2 STRING: ENSP00000367407
    SMPD1P174052, 3, ENSP000003404094MINT-8247910 I2D: score=2 STRING: ENSP00000340409
    NFKB1P198383, ENSP000002265744I2D: score=2 STRING: ENSP00000226574
    ACTA1P681333, ENSP000003556454I2D: score=1 STRING: ENSP00000355645
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS16130169
    GO:0030855epithelial cell differentiation IEP--
    GO:0043066negative regulation of apoptotic process TAS16130169
    GO:0043086negative regulation of catalytic activity NAS2970257
    GO:0050819negative regulation of coagulation ----

    Find genes that share ontologies with ANXA4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANXA4

    1 HMDB Compound for ANXA4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for ANXA4 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylserine 38.1 9 17440717 (3), 8417975 (2), 1828227 (1), 9084877 (1) (see all 5)
    phospholipid 35.9 3 17440717 (1), 7798247 (1), 9084877 (1)
    inosine monophosphate 26.5 1 7763314 (1)
    enterotoxin 22.3 2 2117633 (1), 10085033 (1)
    phosphatidylcholine 18.9 3 8417975 (2), 9084877 (1)
    manganese superoxide 18.7 2 15108329 (1), 16343079 (1)
    calcium 17.6 16 8747277 (3), 9405281 (2), 1828227 (1), 9600863 (1) (see all 9)
    phosphatidylethanolamine 4.89 1 1828227 (1)
    ethanol 0 14 12960510 (5), 12393176 (5), 12198374 (3)
    lysine 0 1 11866428 (1)



    Find genes that share compounds with ANXA4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANXA4 gene: 
    NM_001153.3  

    Unigene Cluster for ANXA4:

    Annexin A4
    Hs.422986  [show with all ESTs]
    Unigene Representative Sequence: BX641114
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418066 ENST00000477632 ENST00000409920(uc010yqn.1) ENST00000394295(uc002sfr.4 uc002sfs.4 uc010yqo.2)
    ENST00000460439 ENST00000460942 ENST00000487351 ENST00000484219 ENST00000468815
    ENST00000472124 ENST00000471395 ENST00000536030
    miRNA
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    Block miRNA regulation of human, mouse, rat ANXA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANXA4 (see all 22):
    hsa-miR-3673 hsa-miR-607 hsa-miR-488 hsa-miR-650 hsa-miR-374c hsa-miR-124 hsa-miR-641 hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidANXA4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANXA4
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANXA4 (NM_001153)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ANXA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANXA4
      QuantiTect SYBR Green Assays in human, mouse, rat ANXA4
      QuantiFast Probe-based Assays in human, mouse, rat ANXA4

    Additional mRNA sequence: 

    AB209457.1 AK058017.1 AK293177.1 AK293396.1 AK293406.1 AK303960.1 AK315511.1 AY453398.1 
    BC000182.1 BC011659.1 BC063672.1 BX641114.1 CR407681.1 D78152.1 M19383.1 M82809.1 

    20 DOTS entries:

    DT.87017339  DT.91788305  DT.97810553  DT.100798192  DT.95159525  DT.101983310  DT.120967843  DT.91809487 
    DT.120967731  DT.75100760  DT.100735320  DT.100798188  DT.100798190  DT.120967728  DT.120967801  DT.433002 
    DT.95159520  DT.95159526  DT.97792813  DT.97847085 

    Selected AceView cDNA sequences (see all 438):

    AA344063 BG251841 CA941888 CB266880 W42693 BC011659 AA705076 BX417409 
    BF589889 AA173435 CB146247 CA749075 BQ788015 BP345566 AU134932 BG620812 
    CK902642 CD512108 BG250906 AI366068 R74067 CA418979 D78152 BP345007 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANXA4 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                                      -                 -           -     -           -                       -                     
    SP2:                                                        -           -     -           -                       -                     
    SP3:                                                                    -     -           -                       -                     
    SP4:                                                                                      -                                             
    SP5:                                                                                                              -                     


    ECgene alternative splicing isoforms for ANXA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANXA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGACTTCC
    ANXA4 Expression
    About this image


    ANXA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    ANXA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANXA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.422986
        Pathway & Disease-focused RT2 Profiler PCR Array including ANXA4: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ANXA4
    OriGene qSTAR qPCR primer pairs in human, mouse for ANXA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANXA4
    QuantiTect SYBR Green Assays in human, mouse, rat ANXA4
    QuantiFast Probe-based Assays in human, mouse, rat ANXA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANXA4 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anxa41 , 5 annexin A41, 5 86.52(n)1
    92.16(a)1
      6 (37.75 cM)5
    117461  NM_013471.21  NP_038499.21 
     867368405 
    chicken
    (Gallus gallus)
    Aves LOC7723931 annexin A4-like 71.88(n)
    75.72(a)
      772393  XM_004947647.1  XP_004947704.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA46
    annexin A4
    76(a)
    1 ↔ 1
    AAWZ02038318(3020-11682)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060389.12   -- 75.37(n)    BC060389.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054622.12   -- 71.76(n)   353362  BC054622.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nex-23 Annexin 48(a)
    (best of 3)
      III(10397630-10399688)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ANN51 ANN5 48.33(n)
    39.33(a)
      843137  NM_105479.1  NP_564920.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.20862 Transcribed sequence with weak similarity to protein more 74.78(n)    AL505620.1 


    ENSEMBL Gene Tree for ANXA4 (if available)
    TreeFam Gene Tree for ANXA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANXA4 gene
    ANXA32  ANXA62  ANXA52  ANXA12  ANXA92  ANXA22  ANXA72  ANXA82  
    ANXA112  ANXA8L22  ANXA102  ANXA8L12  ANXA132  
    15 SIMAP similar genes for ANXA4 using alignment to 4 protein entries:     ANXA4_HUMAN (see all proteins):
    DKFZp686H02120    ANXA11    ANXA8L2    ANXA5    ANXA3    ANXA7
    ANXA6    ANXA13    ANXA2P2    ANXA8    ANXA2    ANXA1
    ANXA10    ANXA8L1    ANXA9

    Find genes that share paralogs with ANXA4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANXA4 (see all 1817)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs713973521,2
    C--69863583(+) AGCAATCAT/-  
            
    TGAGG
    1 -- int11Minor allele frequency- -:0.50NA 2
    rs753998991,2
    C,F--69967255(+) CACCTA/GGTAAA 1 -- us2k12Minor allele frequency- G:0.06WA NA 238
    rs1478608591,2
    --69967283(+) GCCAAC/TGCATC 1 -- us2k10--------
    rs729030341,2
    C,F--69967465(+) TCACCT/CGGCCT 1 -- us2k13Minor allele frequency- C:0.16WA CSA 122
    rs580622221,2
    C--69967538(+) TTTCAT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs134230791,2
    C--69967581(+) GttttA/Gttttt 1 -- us2k10--------
    rs1145246771,2
    F--69967680(+) TCCTGG/AGTTTA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1907629611,2
    --69967692(+) AGTGAA/TCCTCC 1 -- us2k10--------
    rs48529821,2
    C,F--69967726(+) GGACTA/GCAGGC 1 -- us2k14Minor allele frequency- G:0.23NA EA 244
    rs21364411,2
    C,F--69967732(+) CAGGCG/ATGGCT 1 -- us2k11Minor allele frequency- A:0.30EA 120

    HapMap Linkage Disequilibrium report for ANXA4 (69871557 - 70053596 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ANXA4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657606CNV Deletion23128226
    esv33940CNV Loss17666407
    esv7380CNV Gain19470904
    nsv834254CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANXA4
    DNA2.0 Custom Variant and Variant Library Synthesis for ANXA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 106491    OMIM disorders: --

    3 diseases for ANXA4:    
    About MalaCards
    papillary serous adenocarcinoma    legionnaires' disease    gonorrhea

    1 disease from the University of Copenhagen DISEASES database for ANXA4:
    Gonorrhea

    Find genes that share disorders with ANXA4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ANXA4 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    latent infection 17.9 1 12351397 (1)
    autoimmune diseases 10.6 2 16787663 (1), 8990163 (1)
    glioma 4.85 3 12960510 (1), 12198374 (1)
    influenza 2.72 3 8709291 (1), 10880734 (1), 1707655 (1)
    carcinoma squamous cell 0 1 8824783 (1)
    shock 0 4 15108329 (1), 17376711 (1), 15989238 (1), 15924290 (1)
    adenocarcinoma 0 2 9094435 (1), 12198374 (1)
    colorectal cancer 0 2 17376711 (1), 18707159 (1)
    tumors 0 3 8882729 (1), 9486814 (1), 15604267 (1)
    carcinoma 0 3 15145526 (1), 19598262 (1), 19955935 (1)

    Genetic Association Database (GAD): ANXA4
    Human Genome Epidemiology (HuGE) Navigator: ANXA4 (4 documents)

    Export disorders for ANXA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANXA4 gene, integrated from 10 sources (see all 191):
    (articles sorted by number of sources associating them with ANXA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal mapping of the human annexin IV (ANX4) gene. (PubMed id 1346776)1, 2, 3, 9 Tait J.F....Disteche C.M. (Genomics 1992)
    2. Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17. (PubMed id 9084877)1, 2, 9 Satoh A....Matsumoto I. (Biol. Pharm. Bull. 1997)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV. (PubMed id 2254922)1, 2 Freemont P.S.... Crumpton M.J. (J. Mol. Biol. 1990)
    7. Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor. (PubMed id 2974032)1, 2 Ahn N.G....de Haen C. (J. Biol. Chem. 1988)
    8. Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family. (PubMed id 2975506)1, 2 Tait J.F.... Fujikawa K. (Biochemistry 1988)
    9. Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family. (PubMed id 2970257)1, 2 Grundmann U.... Kuepper H.A. (Behring Inst. Mitt. 1988)
    10. Annexin A4 self-association modulates general membrane protein mobility in living cells. (PubMed id 16687573)1, 9 Piljic A. and Schultz C. (Mol. Biol. Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 307 HGNC: 542 AceView: ANXA4 Ensembl:ENSG00000196975 euGenes: HUgn307
    ECgene: ANXA4 H-InvDB: ANXA4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ANXA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ANXA4 gene:
    Search GeneIP for patents involving ANXA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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