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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANXA4 Gene

protein-coding   GIFtS: 63
GCID: GC02P069947

annexin A4


(Previous symbol: ANX4)
 Explore 36 diseases affiliated with
ANXA4 via our new
 Human Malady Compendium 
Biological research products
for ANXA4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Annexin A41 2     PIG282
ANX41 2 3 5     ZAP362
Carbohydrate-Binding Protein P33/P412 3     Annexin IV (Placental Anticoagulant Protein II)2
Endonexin I2 3     Annexin-43
Lipocortin IV2 3     Chromobindin-43
Placental Anticoagulant Protein II2 3     Proliferation-Inducing Gene 282
Protein II2 3     Proliferation-Inducing Protein 282
35-Beta Calcimedin2 3     Annexin-43
P32.52 3     Chromobindin-43
PAP-II2 3     Annexin IV3
PP4-X2 3     

External Ids:    HGNC: 5421   Entrez Gene: 3072   Ensembl: ENSG000001969757   OMIM: 1064915   UniProtKB: P095253   

Export aliases for ANXA4 gene to outside databases

Previous GC identifers: GC02P070018 GC02P070180 GC02P069926 GC02P069943 GC02P069880 GC02P069705


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANXA4:
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their
functions are still not clearly defined, several members of the annexin family have been implicated in
membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of
its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a
protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits
phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ANXA4_HUMAN, P09525
Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis (By
similarity)

Gene Wiki entry for ANXA4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANXA4 gene promoter:
         HOXA9B   HOXA9   Max1   NCX/Ncx   HSF1 (long)   C/EBPalpha   HSF1short   Meis-1a   c-Myc   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ANXA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANXA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13.3

ANXA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P069947:  view genomic region     (about GC identifiers)

Start:
69,947,923 bp from pter      End:
70,053,596 bp from pter
Size:
105,674 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANXA4_HUMAN, P09525 (See protein sequence)
Recommended Name: Annexin A4  
Size: 319 amino acids; 35883 Da
Miscellaneous: Seems to bind one calcium ion with high affinity
Sequence caution: Sequence=AAC41689.1; Type=Erroneous initiation; Sequence=AAH00182.1; Type=Erroneous initiation;
Sequence=AAH11659.1; Type=Erroneous initiation; Sequence=BAA11227.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ANXA4:
2ZOC (3D)    
Secondary accessions: Q96F33 Q9BWK1

Explore the universe of human proteins at neXtProt for ANXA4: NX_P09525

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09525

  • ANXA4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001144.1  
    ENSEMBL proteins: 
     ENSP00000386756   ENSP00000377833   ENSP00000441931  

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    Uscn Proteins for ANXA4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS16130169


    ANXA4 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ANXA4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002391 AnnexinIV
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR018502 Annexin_repeat

    Graphical View of Domain Structure for InterPro Entry P09525

    ProtoNet protein and cluster: P09525

    2 Blocks protein families:
    IPB001464 Annexin
    IPB002391 Annexin type IV signature


    UniProtKB/Swiss-Prot: ANXA4_HUMAN, P09525
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ANXA4_HUMAN, P09525
    Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis (By
    similarity)

         Genatlas biochemistry entry for ANXA4:
    annexin A4,calcium and phospholipid binding protein,calcimedin 35 beta,chromobindin 4,endonexin 1

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity NAS2970257
    GO:0005509calcium ion binding NAS--
    GO:0005544calcium-dependent phospholipid binding NAS2970257


    ANXA4 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for ANXA4:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Lamellipodia cells 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Anxa4):
     behavior/neurological  renal/urinary system 

    ANXA4 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Prostaglandin Synthesis and Regulation
    Prostaglandin Synthesis and Regulation1.00


    1 BioSystems Pathway for ANXA4 
        Prostaglandin Synthesis and Regulation


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANXA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/19 Interacting proteins for ANXA4 (P095252, 3 ENSP000003778334) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NMT2O605512, 3, ENSP000003674074MINT-8247899 I2D: score=2 STRING: ENSP00000367407
    SMPD1P174052, 3, ENSP000003404094MINT-8247910 I2D: score=2 STRING: ENSP00000340409
    NFKB1P198383, ENSP000002265744I2D: score=2 STRING: ENSP00000226574
    H2AFXP161043, ENSP000003643104I2D: score=1 STRING: ENSP00000364310
    GP2P552593, ENSP000003707674I2D: score=2 STRING: ENSP00000370767
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS16130169
    GO:0043066negative regulation of apoptotic process TAS16130169
    GO:0050819negative regulation of coagulation ----


    ANXA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANXA4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANXA4

    1 HMDB Compound for ANXA4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    10/22 Novoseek chemical compound relationships for ANXA4 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylserine 38.1 9 17440717 (3), 8417975 (2), 1828227 (1), 9084877 (1) (see all 5)
    phospholipid 35.9 3 17440717 (1), 7798247 (1), 9084877 (1)
    inosine monophosphate 26.5 1 7763314 (1)
    enterotoxin 22.3 2 2117633 (1), 10085033 (1)
    phosphatidylcholine 18.9 3 8417975 (2), 9084877 (1)
    manganese superoxide 18.7 2 15108329 (1), 16343079 (1)
    calcium 17.6 16 8747277 (3), 9405281 (2), 1828227 (1), 9600863 (1) (see all 9)
    phosphatidylethanolamine 4.89 1 1828227 (1)
    ethanol 0 14 12960510 (5), 12393176 (5), 12198374 (3)
    lysine 0 1 11866428 (1)

    Search CenterWatch for drugs/clinical trials and news about ANXA4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANXA4 gene: 
    NM_001153.3  

    Unigene Cluster for ANXA4:

    Annexin A4
    Hs.422986  [show with all ESTs]
    Unigene Representative Sequence: BX641114
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477632 ENST00000409920(uc010yqn.1) ENST00000394295(uc002sfr.4 uc002sfs.4 uc010yqo.2)
    ENST00000460439 ENST00000460942 ENST00000487351 ENST00000484219 ENST00000468815
    ENST00000472124 ENST00000471395 ENST00000536030

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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate ANXA4 (see all 22):
    hsa-miR-3673 hsa-miR-607 hsa-miR-488 hsa-miR-650 hsa-miR-374c hsa-miR-124 hsa-miR-641 hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidANXA4 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB209457.1 AK058017.1 AK293177.1 AK293396.1 AK293406.1 AK303960.1 AK315511.1 AY453398.1 
    BC000182.1 BC011659.1 BC063672.1 BX641114.1 CR407681.1 D78152.1 M19383.1 M82809.1 

    20 DOTS entries:

    DT.87017339  DT.91788305  DT.97810553  DT.100798192  DT.95159525  DT.101983310  DT.120967843  DT.91809487 
    DT.120967731  DT.75100760  DT.100735320  DT.100798188  DT.100798190  DT.120967728  DT.120967801  DT.433002 
    DT.95159520  DT.95159526  DT.97792813  DT.97847085 

    24/438 AceView cDNA sequences (see all 438):

    CA941888 CA749075 AA344063 N91966 CD678034 CA432419 BP341358 BU947611 
    BM987088 CB068341 AU134932 BM787734 BM824930 CB146247 BP375914 AV728154 
    BU633883 AV661414 CR602990 AA299972 N74071 CD512108 CA418979 BC000182 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ANXA4 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                                      -                 -           -     -           -                       -                     
    SP2:                                                        -           -     -           -                       -                     
    SP3:                                                                    -     -           -                       -                     
    SP4:                                                                                      -                                             
    SP5:                                                                                                              -                     


    ECgene alternative splicing isoforms for ANXA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANXA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGACTTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ANXA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANXA4

    SOURCE GeneReport for Unigene cluster: Hs.422986
        SABiosciences Expression via Pathway-Focused PCR Array including ANXA4: 
              Apoptosis 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANXA4 gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    --
    71(a)
    53(a)
    1 ↔ many
    1 ↔ many
    Un(49778941-49782567)
    Un(38032953-38042694)
    lizard
    (Anolis carolinensis)
    Reptilia ANXA46
    --
    76(a)
    1 ↔ 1
    AAWZ02038318(6920-11158)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060389.12   -- 75.37(n)    BC060389.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054622.12   -- 71.76(n)   353362  BC054622.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AnnIX3 actin binding 51(a)
    (best of 3)
      93B10   --
    worm
    (Caenorhabditis elegans)
    Secernentea nex-23 Annexin 48(a)
    (best of 3)
      III(10397630-10399688)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ANNAT56
    ANNAT86
    (see all 8)
    annexin D8
    (see all 8)
    38(a)
    32(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    1(25519442-25520774)
    5(4009223-4010687)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 9)
    annexin, putative, expressed
    (see all 9)
    40(a)
    36(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    9(13705487-13710510)
    8(20456985-20458908)


    ENSEMBL Gene Tree for ANXA4 (if available)
    TreeFam Gene Tree for ANXA4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANXA4 gene
    ANXA32  ANXA62  ANXA12  ANXA52  ANXA92  ANXA22  ANXA72  ANXA82  
    ANXA112  ANXA8L22  ANXA102  ANXA8L12  ANXA132  
    15 SIMAP similar genes for ANXA4 using alignment to 4 protein entries:     ANXA4_HUMAN (see all proteins):
    DKFZp686H02120    ANXA11    ANXA8L2    ANXA3    ANXA7    ANXA6
    ANXA13    ANXA5    ANXA2P2    ANXA8    ANXA2    ANXA1
    ANXA10    ANXA8L1    ANXA9

    ANXA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1538 NCBI SNPs in ANXA4 are shown (see all 1538    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs753998991,2
    C,F,--69967255(+) CACCTA/GGTAAA 1 -- us2k12Minor allele frequency- G:0.06WA NA 238
    rs1478608591,2
    --69967283(+) GCCAAC/TGCATC 1 -- us2k10--------
    rs729030341,2
    C,F,--69967465(+) TCACCT/CGGCCT 1 -- us2k13Minor allele frequency- C:0.16WA CSA 122
    rs580622221,2
    C,--69967538(+) TTTCAT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs134230791,2
    C,--69967581(+) GttttA/Gttttt 1 -- us2k10--------
    rs1145246771,2
    F,--69967680(+) TCCTGG/AGTTTA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1907629611,2
    --69967692(+) AGTGAA/TCCTCC 1 -- us2k10--------
    rs48529821,2
    C,F,--69967726(+) GGACTA/GCAGGC 1 -- us2k14Minor allele frequency- G:0.23NA EA 244
    rs21364411,2
    F,--69967732(+) CAGGCG/ATGGCT 1 -- us2k11Minor allele frequency- A:0.30EA 120
    rs1423340161,2
    --69967738(+) TGGCTA/GTGCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANXA4 (69947923 - 70053596 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ANXA4
         1 CNV: 7279
         1 Indel: 60302

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ANXA4 for disorders           About GeneDecksing

    OMIM gene information: 106491    OMIM disorders: --

    20/36 diseases for ANXA4 (see all 36):    About MalaCards
    dna topoisomerase ii    bare lymphocyte syndrome    clear cell adenocarcinoma    nemaline myopathy
    ovarian clear cell adenocarcinoma    renal clear cell carcinoma    trigonitis    legionnaires' disease
    rheumatoid arthritis, association with    rheumatoid arthritis    gonorrhea    renal cell carcinoma
    squamous cell carcinoma    dermatomyositis    myopathy    leprosy
    influenza    colorectal cancer    adenocarcinoma    arthritis

    1 disease from the University of Copenhagen DISEASES database for ANXA4:
    Gonorrhea

    10/13 Novoseek disease relationships for ANXA4 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    latent infection 17.9 1 12351397 (1)
    autoimmune diseases 10.6 2 16787663 (1), 8990163 (1)
    glioma 4.85 3 12960510 (1), 12198374 (1)
    influenza 2.72 3 8709291 (1), 10880734 (1), 1707655 (1)
    carcinoma squamous cell 0 1 8824783 (1)
    shock 0 4 15108329 (1), 17376711 (1), 15989238 (1), 15924290 (1)
    adenocarcinoma 0 2 9094435 (1), 12198374 (1)
    colorectal cancer 0 2 17376711 (1), 18707159 (1)
    tumors 0 3 8882729 (1), 9486814 (1), 15604267 (1)
    carcinoma 0 3 15145526 (1), 19598262 (1), 19955935 (1)

    Human Genome Epidemiology (HuGE) Navigator: ANXA4 (4 documents)

    Export disorders for ANXA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANXA4 gene, integrated from 9 sources (see all 184):
    (articles sorted by number of sources associating them with ANXA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal mapping of the human annexin IV (ANX4) gene. (PubMed id 1346776)1, 2, 3, 9 Tait J.F....Disteche C.M. (1992)
    2. Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17. (PubMed id 9084877)1, 2, 9 Satoh A....Matsumoto I. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV. (PubMed id 2254922)1, 2 Freemont P.S.... Crumpton M.J. (1990)
    5. Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor. (PubMed id 2974032)1, 2 Ahn N.G....de Haen C. (1988)
    6. Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family. (PubMed id 2975506)1, 2 Tait J.F.... Fujikawa K. (1988)
    7. Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family. (PubMed id 2970257)1, 2 Grundmann U.... Kuepper H.A. (1988)
    8. Annexin A4 self-association modulates general membrane protein mobility in living cells. (PubMed id 16687573)1, 9 Piljic A. and Schultz C. (2006)
    9. Modulation of paclitaxel resistance by annexin IV in human cancer cell lines. (PubMed id 10883672)1, 9 Han E.K....Ng S.C. (2000)
    10. Expression of carbohydrate-binding protein p33/41 in human tumor cell lines. (PubMed id 8882729)1, 9 Satoh A....Matsumoto I. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 307 HGNC: 542 AceView: ANXA4 Ensembl:ENSG00000196975 euGenes: HUgn307
    ECgene: ANXA4 H-InvDB: ANXA4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANXA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANXA4 gene:
    Search GeneIP for patents involving ANXA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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