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Aliases for ANXA4 Gene

Aliases for ANXA4 Gene

  • Annexin A4 2 3
  • Carbohydrate-Binding Protein P33/P41 3 4
  • Placental Anticoagulant Protein II 3 4
  • 35-Beta Calcimedin 3 4
  • Chromobindin-4 3 4
  • Lipocortin IV 3 4
  • Endonexin I 3 4
  • Protein II 3 4
  • Annexin-4 3 4
  • PAP-II 3 4
  • P32.5 3 4
  • PP4-X 3 4
  • ANX4 3 4
  • Annexin IV (Placental Anticoagulant Protein II) 3
  • Epididymis Secretory Protein Li 274 3
  • Proliferation-Inducing Protein 28 3
  • Proliferation-Inducing Gene 28 3
  • Annexin IV 4
  • HEL-S-274 3
  • PIG28 3
  • ZAP36 3

External Ids for ANXA4 Gene

Previous HGNC Symbols for ANXA4 Gene

  • ANX4

Previous GeneCards Identifiers for ANXA4 Gene

  • GC02P070018
  • GC02P070180
  • GC02P069926
  • GC02P069943
  • GC02P069880
  • GC02P069947
  • GC02P069872

Summaries for ANXA4 Gene

Entrez Gene Summary for ANXA4 Gene

  • Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA4 Gene

ANXA4 (Annexin A4) is a Protein Coding gene. Among its related pathways are Prostaglandin Synthesis and Regulation. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is ANXA9.

UniProtKB/Swiss-Prot for ANXA4 Gene

  • Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

Gene Wiki entry for ANXA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA4 Gene

Genomics for ANXA4 Gene

Regulatory Elements for ANXA4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANXA4 Gene

Chromosome:
2
Start:
69,644,100 bp from pter
End:
69,826,464 bp from pter
Size:
182,365 bases
Orientation:
Plus strand

Genomic View for ANXA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANXA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA4 Gene

Proteins for ANXA4 Gene

  • Protein details for ANXA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09525-ANXA4_HUMAN
    Recommended name:
    Annexin A4
    Protein Accession:
    P09525
    Secondary Accessions:
    • B4DDF9
    • Q96F33
    • Q9BWK1

    Protein attributes for ANXA4 Gene

    Size:
    319 amino acids
    Molecular mass:
    35883 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Seems to bind one calcium ion with high affinity
    SequenceCaution:
    • Sequence=AAC41689.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH00182.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH11659.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA11227.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANXA4 Gene

    Alternative splice isoforms for ANXA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANXA4 Gene

Proteomics data for ANXA4 Gene at MOPED

Post-translational modifications for ANXA4 Gene

  • Ubiquitination at Lys 293
  • Modification sites at PhosphoSitePlus

Other Protein References for ANXA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ANXA4 Gene

Domains & Families for ANXA4 Gene

Gene Families for ANXA4 Gene

Protein Domains for ANXA4 Gene

Graphical View of Domain Structure for InterPro Entry

P09525

UniProtKB/Swiss-Prot:

ANXA4_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid
Family:
  • Belongs to the annexin family.
Similarity:
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA4: view

Function for ANXA4 Gene

Molecular function for ANXA4 Gene

GENATLAS Biochemistry:
annexin A4,calcium and phospholipid binding protein,calcimedin 35 beta,chromobindin 4,endonexin 1
UniProtKB/Swiss-Prot Function:
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

Gene Ontology (GO) - Molecular Function for ANXA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity NAS 2970257
GO:0005509 calcium ion binding IDA 20237821
GO:0005544 calcium-dependent phospholipid binding NAS 2970257
GO:0042802 identical protein binding IPI 16687573
GO:0048306 calcium-dependent protein binding IPI 15226301
genes like me logo Genes that share ontologies with ANXA4: view
genes like me logo Genes that share phenotypes with ANXA4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANXA4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ANXA4 Gene

Localization for ANXA4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA4 Gene COMPARTMENTS Subcellular localization image for ANXA4 gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 4
cytoskeleton 2
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ANXA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16687573
GO:0005737 cytoplasm TAS 16130169
GO:0005886 plasma membrane IDA 16687573
GO:0009986 cell surface IDA 22056994
GO:0012506 vesicle membrane IDA 16687573
genes like me logo Genes that share ontologies with ANXA4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA4 Gene

Pathways & Interactions for ANXA4 Gene

genes like me logo Genes that share pathways with ANXA4: view

Pathways by source for ANXA4 Gene

1 BioSystems pathway for ANXA4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ANXA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 20237821
GO:0007165 signal transduction TAS 16130169
GO:0007219 Notch signaling pathway IEA --
GO:0030855 epithelial cell differentiation IEP 21492153
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 20237821
genes like me logo Genes that share ontologies with ANXA4: view

No data available for SIGNOR curated interactions for ANXA4 Gene

Drugs & Compounds for ANXA4 Gene

(12) Drugs for ANXA4 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma 1708
Heparin Approved, Investigational Pharma Antagonist 672,226
Phosphatidylserine Approved Nutra 0
Phosphatidylethanolamine Experimental Pharma 0
Sucrose Experimental Pharma 0

(10) Additional Compounds for ANXA4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
chloride
Enterotoxin
Fatty acid
hydrogen
  • Dihydrogen
  • Hydrogen gas
1333-74-0
inosine monophosphate
genes like me logo Genes that share compounds with ANXA4: view

Transcripts for ANXA4 Gene

Unigene Clusters for ANXA4 Gene

Annexin A4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANXA4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for ANXA4 Gene

GeneLoc Exon Structure for
ANXA4
ECgene alternative splicing isoforms for
ANXA4

Expression for ANXA4 Gene

mRNA expression in normal human tissues for ANXA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA4 Gene

This gene is overexpressed in Pancreas (x7.2).

Protein differential expression in normal tissues from HIPED for ANXA4 Gene

This gene is overexpressed in Islet of Langerhans (9.2) and Gallbladder (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA4 Gene



SOURCE GeneReport for Unigene cluster for ANXA4 Gene Hs.422986

genes like me logo Genes that share expression patterns with ANXA4: view

Protein tissue co-expression partners for ANXA4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ANXA4 Gene

Orthologs for ANXA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANXA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANXA4 35
  • 91.64 (n)
  • 94.67 (a)
ANXA4 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA4 35
  • 88.61 (n)
  • 92.79 (a)
ANXA4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa4 35
  • 86.52 (n)
  • 92.16 (a)
Anxa4 16
Anxa4 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANXA4 35
  • 99.58 (n)
  • 99.69 (a)
ANXA4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa4 35
  • 87.36 (n)
  • 92.79 (a)
oppossum
(Monodelphis domestica)
Mammalia ANXA4 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC772393 35
  • 71.88 (n)
  • 75.72 (a)
ANXA4 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA4 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa4 35
  • 70.74 (n)
  • 74.92 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
anxa4 35
  • 65.1 (n)
  • 63.75 (a)
anxa4 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 37
  • 51 (a)
AnnX 37
  • 46 (a)
Anxb11 37
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea nex-1 37
  • 41 (a)
nex-2 37
  • 48 (a)
nex-3 37
  • 38 (a)
nex-2 36
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ANN5 35
  • 48.33 (n)
  • 39.33 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2086 35
corn
(Zea mays)
Liliopsida Zm.13766 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for ANXA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA4 Gene

ENSEMBL:
Gene Tree for ANXA4 (if available)
TreeFam:
Gene Tree for ANXA4 (if available)

Paralogs for ANXA4 Gene

Paralogs for ANXA4 Gene

genes like me logo Genes that share paralogs with ANXA4: view

Variants for ANXA4 Gene

Sequence variations from dbSNP and Humsavar for ANXA4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7589995 -- 69,753,295(+) CTTGC(A/G)TAAGA intron-variant
rs7589674 -- 69,696,774(+) agttc(C/T)tgggt intron-variant
rs7588022 -- 69,796,337(+) tcttt(C/T)tctcc intron-variant
rs7586494 -- 69,779,983(+) TGAAA(C/T)TGGAA intron-variant
rs7584522 -- 69,679,356(+) tttca(A/G)tggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA4 Gene

Variant ID Type Subtype PubMed ID
esv33940 CNV Loss 17666407
nsv834254 CNV Gain 17160897
esv7380 CNV Gain 19470904
esv2657606 CNV Deletion 23128226

Variation tolerance for ANXA4 Gene

Residual Variation Intolerance Score: 62.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.06; 84.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANXA4 Gene

HapMap Linkage Disequilibrium report
ANXA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA4 Gene

Disorders for ANXA4 Gene

Relevant External Links for ANXA4

Genetic Association Database (GAD)
ANXA4
Human Genome Epidemiology (HuGE) Navigator
ANXA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANXA4
genes like me logo Genes that share disorders with ANXA4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA4 Gene

Publications for ANXA4 Gene

  1. Chromosomal mapping of the human annexin IV (ANX4) gene. (PMID: 1346776) Tait J.F. … Disteche C.M. (Genomics 1992) 2 23 67
  2. Crystal structures of sodium-bound annexin A4. (PMID: 19809188) Butsushita K. … Arii Y. (Biosci. Biotechnol. Biochem. 2009) 23 67
  3. Proteomic investigation in A549 lung cell line stably infected by HPV16E6/E7 oncogenes. (PMID: 19023193) Ciotti M. … Federici G. (Respiration 2009) 23 67
  4. Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: a molecular dynamics simulation study. (PMID: 18767126) Yaneva R. … Zacharias M. (Biopolymers 2009) 23 67
  5. Enhanced expression of Annexin A4 in clear cell carcinoma of the ovary and its association with chemoresistance to carboplatin. (PMID: 19598262) Kim A. … Naka T. (Int. J. Cancer 2009) 23 67

Products for ANXA4 Gene

Sources for ANXA4 Gene

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