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Aliases for ANXA4 Gene

Aliases for ANXA4 Gene

  • Annexin A4 2 3 5
  • Carbohydrate-Binding Protein P33/P41 3 4
  • Placental Anticoagulant Protein II 3 4
  • 35-Beta Calcimedin 3 4
  • Chromobindin-4 3 4
  • Lipocortin IV 3 4
  • Endonexin I 3 4
  • Protein II 3 4
  • Annexin-4 3 4
  • PAP-II 3 4
  • P32.5 3 4
  • PP4-X 3 4
  • ANX4 3 4
  • Annexin IV (Placental Anticoagulant Protein II) 3
  • Epididymis Secretory Protein Li 274 3
  • Proliferation-Inducing Protein 28 3
  • Proliferation-Inducing Gene 28 3
  • Annexin IV 4
  • HEL-S-274 3
  • PIG28 3
  • ZAP36 3

External Ids for ANXA4 Gene

Previous HGNC Symbols for ANXA4 Gene

  • ANX4

Previous GeneCards Identifiers for ANXA4 Gene

  • GC02P070018
  • GC02P070180
  • GC02P069926
  • GC02P069943
  • GC02P069880
  • GC02P069947
  • GC02P069872

Summaries for ANXA4 Gene

Entrez Gene Summary for ANXA4 Gene

  • Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

GeneCards Summary for ANXA4 Gene

ANXA4 (Annexin A4) is a Protein Coding gene. Among its related pathways are Prostaglandin Synthesis and Regulation. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is ANXA2.

UniProtKB/Swiss-Prot for ANXA4 Gene

  • Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

Gene Wiki entry for ANXA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA4 Gene

Genomics for ANXA4 Gene

Regulatory Elements for ANXA4 Gene

Enhancers for ANXA4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANXA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANXA4 Gene

69,644,100 bp from pter
69,827,100 bp from pter
183,001 bases
Plus strand

Genomic View for ANXA4 Gene

Genes around ANXA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA4 Gene

Proteins for ANXA4 Gene

  • Protein details for ANXA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin A4
    Protein Accession:
    Secondary Accessions:
    • B4DDF9
    • Q96F33
    • Q9BWK1

    Protein attributes for ANXA4 Gene

    319 amino acids
    Molecular mass:
    35883 Da
    Quaternary structure:
    No Data Available
    • Seems to bind one calcium ion with high affinity.
    • Sequence=AAC41689.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH00182.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH11659.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA11227.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANXA4 Gene

    Alternative splice isoforms for ANXA4 Gene


neXtProt entry for ANXA4 Gene

Proteomics data for ANXA4 Gene at MOPED

Post-translational modifications for ANXA4 Gene

  • Ubiquitination at Lys 293
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANXA4 Gene

Domains & Families for ANXA4 Gene

Gene Families for ANXA4 Gene

Protein Domains for ANXA4 Gene

Graphical View of Domain Structure for InterPro Entry



  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA4: view

Function for ANXA4 Gene

Molecular function for ANXA4 Gene

GENATLAS Biochemistry:
annexin A4,calcium and phospholipid binding protein,calcimedin 35 beta,chromobindin 4,endonexin 1
UniProtKB/Swiss-Prot Function:
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

Gene Ontology (GO) - Molecular Function for ANXA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity NAS 2970257
GO:0005544 calcium-dependent phospholipid binding IEA,NAS 2970257
genes like me logo Genes that share ontologies with ANXA4: view
genes like me logo Genes that share phenotypes with ANXA4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ANXA4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANXA4 Gene

Localization for ANXA4 Gene

Subcellular locations from

Jensen Localization Image for ANXA4 Gene COMPARTMENTS Subcellular localization image for ANXA4 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
cytosol 4
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ANXA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16687573
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ANXA4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA4 Gene

Pathways & Interactions for ANXA4 Gene

genes like me logo Genes that share pathways with ANXA4: view

Pathways by source for ANXA4 Gene

1 BioSystems pathway for ANXA4 Gene

Gene Ontology (GO) - Biological Process for ANXA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 16130169
GO:0007219 Notch signaling pathway IEA --
GO:0043066 negative regulation of apoptotic process TAS 16130169
GO:0050819 negative regulation of coagulation IEA --
genes like me logo Genes that share ontologies with ANXA4: view

No data available for SIGNOR curated interactions for ANXA4 Gene

Drugs & Compounds for ANXA4 Gene

(12) Drugs for ANXA4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(10) Additional Compounds for ANXA4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANXA4: view

Transcripts for ANXA4 Gene

Unigene Clusters for ANXA4 Gene

Annexin A4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: -

Relevant External Links for ANXA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA4 Gene

mRNA expression in normal human tissues for ANXA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA4 Gene

This gene is overexpressed in Pancreas (x7.2).

Protein differential expression in normal tissues from HIPED for ANXA4 Gene

This gene is overexpressed in Islet of Langerhans (9.2) and Gallbladder (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA4 Gene

SOURCE GeneReport for Unigene cluster for ANXA4 Gene Hs.422986

genes like me logo Genes that share expression patterns with ANXA4: view

Protein tissue co-expression partners for ANXA4 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ANXA4 Gene

Orthologs for ANXA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANXA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANXA4 35
  • 91.64 (n)
  • 94.67 (a)
ANXA4 36
  • 95 (a)
(Canis familiaris)
Mammalia ANXA4 35
  • 88.61 (n)
  • 92.79 (a)
ANXA4 36
  • 94 (a)
(Mus musculus)
Mammalia Anxa4 35
  • 86.52 (n)
  • 92.16 (a)
Anxa4 16
Anxa4 36
  • 92 (a)
(Pan troglodytes)
Mammalia ANXA4 35
  • 99.58 (n)
  • 99.69 (a)
ANXA4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Anxa4 35
  • 87.36 (n)
  • 92.79 (a)
(Monodelphis domestica)
Mammalia ANXA4 36
  • 87 (a)
(Gallus gallus)
Aves LOC772393 35
  • 71.88 (n)
  • 75.72 (a)
ANXA4 36
  • 73 (a)
(Anolis carolinensis)
Reptilia ANXA4 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa4 35
  • 70.74 (n)
  • 74.92 (a)
(Danio rerio)
Actinopterygii -- 35
anxa4 35
  • 65.1 (n)
  • 63.75 (a)
anxa4 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 37
  • 51 (a)
AnnX 37
  • 46 (a)
Anxb11 37
  • 49 (a)
(Caenorhabditis elegans)
Secernentea nex-1 37
  • 41 (a)
nex-2 37
  • 48 (a)
nex-3 37
  • 38 (a)
nex-2 36
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ANN5 35
  • 48.33 (n)
  • 39.33 (a)
(Hordeum vulgare)
Liliopsida Hv.2086 35
(Zea mays)
Liliopsida Zm.13766 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for ANXA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA4 Gene

Gene Tree for ANXA4 (if available)
Gene Tree for ANXA4 (if available)

Paralogs for ANXA4 Gene

genes like me logo Genes that share paralogs with ANXA4: view

Variants for ANXA4 Gene

Sequence variations from dbSNP and Humsavar for ANXA4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2228203 - 69,806,452(+) GATGA(C/T)GCCCA reference, missense
rs401724 -- 69,767,912(-) ATGTA(C/T)ATATG intron-variant
rs404573 -- 69,766,873(-) CTTTA(G/T)AGCGC intron-variant
rs420733 -- 69,752,808(-) TTTTG(C/T)GGCAG intron-variant
rs425762 -- 69,774,340(-) aaaaa(A/G)ggggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA4 Gene

Variant ID Type Subtype PubMed ID
esv33940 CNV Loss 17666407
nsv834254 CNV Gain 17160897
esv7380 CNV Gain 19470904
esv2657606 CNV Deletion 23128226

Variation tolerance for ANXA4 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.06; 84.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ANXA4 Gene

Disorders for ANXA4 Gene

Relevant External Links for ANXA4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANXA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA4 Gene

Publications for ANXA4 Gene

  1. Chromosomal mapping of the human annexin IV (ANX4) gene. (PMID: 1346776) Tait J.F. … Disteche C.M. (Genomics 1992) 2 3 4 23 67
  2. Enhanced expression of Annexin A4 in clear cell carcinoma of the ovary and its association with chemoresistance to carboplatin. (PMID: 19598262) Kim A. … Naka T. (Int. J. Cancer 2009) 3 23
  3. Annexin IV is differentially expressed in clear cell carcinoma of the ovary. (PMID: 19955935) Miao Y. … Wan X. (Int. J. Gynecol. Cancer 2009) 3 23
  4. Plasma levels of annexins IV and V in relation to antiphospholipid antibody status in women with a history of recurrent miscarriage. (PMID: 17363042) Ulander V.M. … Kaaja R. (Thromb. Res. 2007) 3 23
  5. Annexin A4 self-association modulates general membrane protein mobility in living cells. (PMID: 16687573) Piljic A. … Schultz C. (Mol. Biol. Cell 2006) 3 23

Products for ANXA4 Gene

Sources for ANXA4 Gene