Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANXA2R Gene

Aliases for ANXA2R Gene

  • Annexin A2 Receptor 2 3 5
  • Annexin II Receptor 3 4
  • C5orf39 3 4
  • AXIIR 3 4
  • AX2R 3 4
  • Chromosome 5 Open Reading Frame 39 2

External Ids for ANXA2R Gene

Previous HGNC Symbols for ANXA2R Gene

  • C5orf39

Summaries for ANXA2R Gene

GeneCards Summary for ANXA2R Gene

ANXA2R (Annexin A2 Receptor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ANXA2R Gene

  • May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA2R Gene

Genomics for ANXA2R Gene

Genomic Location for ANXA2R Gene

Chromosome:
5
Start:
43,039,080 bp from pter
End:
43,043,170 bp from pter
Size:
4,091 bases
Orientation:
Minus strand

Genomic View for ANXA2R Gene

Genes around ANXA2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA2R Gene

No data available for Regulatory Elements for ANXA2R Gene

Proteins for ANXA2R Gene

  • Protein details for ANXA2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCQ2-AX2R_HUMAN
    Recommended name:
    Annexin-2 receptor
    Protein Accession:
    Q3ZCQ2
    Secondary Accessions:
    • Q8NHX5

    Protein attributes for ANXA2R Gene

    Size:
    193 amino acids
    Molecular mass:
    21682 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANXA2R Gene

Proteomics data for ANXA2R Gene at MOPED

Post-translational modifications for ANXA2R Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA2R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ANXA2R Gene

Domains & Families for ANXA2R Gene

Protein Domains for ANXA2R Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANXA2R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANXA2R: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ANXA2R Gene

Function for ANXA2R Gene

Molecular function for ANXA2R Gene

UniProtKB/Swiss-Prot Function:
May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.

Phenotypes for ANXA2R Gene

GenomeRNAi human phenotypes for ANXA2R:
genes like me logo Genes that share phenotypes with ANXA2R: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANXA2R Gene

Localization for ANXA2R Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA2R Gene COMPARTMENTS Subcellular localization image for ANXA2R gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANXA2R Gene

Pathways & Interactions for ANXA2R Gene

SuperPathways for ANXA2R Gene

No Data Available

Interacting Proteins for ANXA2R Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315915%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000315915 for ANXA2R Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for ANXA2R Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANXA2R Gene

Drugs & Compounds for ANXA2R Gene

No Compound Related Data Available

Transcripts for ANXA2R Gene

mRNA/cDNA for ANXA2R Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANXA2R Gene

Annexin A2 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA2R Gene

No ASD Table

Relevant External Links for ANXA2R Gene

GeneLoc Exon Structure for
ANXA2R
ECgene alternative splicing isoforms for
ANXA2R

Expression for ANXA2R Gene

mRNA expression in normal human tissues for ANXA2R Gene

mRNA differential expression in normal tissues according to GTEx for ANXA2R Gene

This gene is overexpressed in Whole Blood (x7.7) and Spleen (x5.4).

SOURCE GeneReport for Unigene cluster for ANXA2R Gene Hs.529385

mRNA Expression by UniProt/SwissProt for ANXA2R Gene

Q3ZCQ2-AX2R_HUMAN
Tissue specificity: Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4(+) and CD8(+) T-cells.
genes like me logo Genes that share expression patterns with ANXA2R: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ANXA2R Gene

Orthologs for ANXA2R Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ANXA2R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANXA2R 35
  • 99.48 (n)
  • 98.96 (a)
ANXA2R 36
  • 99 (a)
OneToOne
Species with no ortholog for ANXA2R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANXA2R Gene

ENSEMBL:
Gene Tree for ANXA2R (if available)
TreeFam:
Gene Tree for ANXA2R (if available)

Paralogs for ANXA2R Gene

Pseudogenes.org Pseudogenes for ANXA2R Gene

genes like me logo Genes that share paralogs with ANXA2R: view

No data available for Paralogs for ANXA2R Gene

Variants for ANXA2R Gene

Sequence variations from dbSNP and Humsavar for ANXA2R Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_033348 -
VAR_033349 -

Variation tolerance for ANXA2R Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANXA2R Gene

HapMap Linkage Disequilibrium report
ANXA2R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANXA2R Gene

Disorders for ANXA2R Gene

Relevant External Links for ANXA2R

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANXA2R

No disorders were found for ANXA2R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA2R Gene

Publications for ANXA2R Gene

  1. Cloning and characterization of the annexin II receptor on human marrow stromal cells. (PMID: 16895901) Lu G. … Roodman G.D. (J. Biol. Chem. 2006) 2 3 4 23 67
  2. Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer. (PMID: 18636554) Shiozawa Y. … Taichman R.S. (J. Cell. Biochem. 2008) 2 3 23
  3. Annexin II receptor induces apoptosis independent of Annexin II. (PMID: 23640736) Xiong Y. … Chen M. (Apoptosis 2013) 3
  4. Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment. (PMID: 22223826) D'Souza S. … Roodman G.D. (Blood 2012) 3
  5. GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. (PMID: 20126470) Shiozawa Y. … Taichman R.S. (Neoplasia 2010) 23

Products for ANXA2R Gene

Sources for ANXA2R Gene

Back to Top

Content