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Aliases for ANXA2R Gene

Aliases for ANXA2R Gene

  • Annexin A2 Receptor 2 3 5
  • Annexin II Receptor 3 4
  • C5orf39 3 4
  • AXIIR 3 4
  • AX2R 3 4
  • Chromosome 5 Open Reading Frame 39 2
  • Annexin-2 Receptor 3

External Ids for ANXA2R Gene

Previous HGNC Symbols for ANXA2R Gene

  • C5orf39

Summaries for ANXA2R Gene

GeneCards Summary for ANXA2R Gene

ANXA2R (Annexin A2 Receptor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ANXA2R Gene

  • May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA2R Gene

Genomics for ANXA2R Gene

Regulatory Elements for ANXA2R Gene

Enhancers for ANXA2R Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F043015 1.5 FANTOM5 ENCODE 33.3 +24.2 24221 6.6 PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 ZNF131 ANXA2R RPL29P12 LOC153684 C5orf34 ENSG00000271788 AMD1P3 TMEM267 LOC105374748 ENSG00000272382
GH05F043006 1.6 FANTOM5 ENCODE 17.8 +33.6 33618 5.5 CREB3L1 ZFP64 YY1 ZNF143 ZNF263 TBX21 MEF2D SSRP1 ZNF610 GLIS1 ZNF131 ANXA2R LOC153684 RPL29P12 C5orf34 ENSG00000271788 AMD1P3 GHR PIR61621
GH05F043033 1.7 FANTOM5 Ensembl ENCODE 12.7 +4.7 4697 10.3 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 NFYC TBX21 ZFP41 ZNF610 ZNF131 RPL29P12 ENSG00000260786 ANXA2R EEF1A1P19 LOC153684 ENSG00000272382 ENSG00000249492 PAIP1 SERBP1P6
GH05F042948 1.6 FANTOM5 Ensembl ENCODE 8 +92.1 92133 4.9 PKNOX1 SIN3A BRCA1 YY1 ZNF143 FOS JUNB ZHX2 SMARCB1 ZNF518A ZNF131 C5orf34 ANXA2R NIM1K LOC105374745 GC05P042919
GH05F043482 1.2 ENCODE 10.1 -441.8 -441838 5.6 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF131 EEF1A1P19 RPL29P12 ENSG00000248240 NNT CCL28 ENSG00000249492 PAIP1 LOC153684 FGF10-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANXA2R on UCSC Golden Path with GeneCards custom track

Genomic Location for ANXA2R Gene

43,039,080 bp from pter
43,043,170 bp from pter
4,091 bases
Minus strand

Genomic View for ANXA2R Gene

Genes around ANXA2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA2R Gene

Proteins for ANXA2R Gene

  • Protein details for ANXA2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin-2 receptor
    Protein Accession:
    Secondary Accessions:
    • Q8NHX5

    Protein attributes for ANXA2R Gene

    193 amino acids
    Molecular mass:
    21682 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANXA2R Gene

Post-translational modifications for ANXA2R Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA2R Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANXA2R Gene

Domains & Families for ANXA2R Gene

Protein Domains for ANXA2R Gene


Suggested Antigen Peptide Sequences for ANXA2R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANXA2R: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ANXA2R Gene

Function for ANXA2R Gene

Molecular function for ANXA2R Gene

UniProtKB/Swiss-Prot Function:
May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.

Gene Ontology (GO) - Molecular Function for ANXA2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
genes like me logo Genes that share ontologies with ANXA2R: view

Phenotypes for ANXA2R Gene

GenomeRNAi human phenotypes for ANXA2R:
genes like me logo Genes that share phenotypes with ANXA2R: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANXA2R Gene

Localization for ANXA2R Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA2R gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANXA2R Gene

Pathways & Interactions for ANXA2R Gene

SuperPathways for ANXA2R Gene

No Data Available

Interacting Proteins for ANXA2R Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q3ZCQ2-AX2R_HUMAN ENSP00000315915 for ANXA2R Gene via IID STRING

Gene Ontology (GO) - Biological Process for ANXA2R Gene


No data available for Pathways by source and SIGNOR curated interactions for ANXA2R Gene

Transcripts for ANXA2R Gene

mRNA/cDNA for ANXA2R Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANXA2R Gene

Annexin A2 receptor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA2R Gene

No ASD Table

Relevant External Links for ANXA2R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA2R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANXA2R Gene

mRNA differential expression in normal tissues according to GTEx for ANXA2R Gene

This gene is overexpressed in Whole Blood (x7.7) and Spleen (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of ANXA2R Gene:


SOURCE GeneReport for Unigene cluster for ANXA2R Gene:


mRNA Expression by UniProt/SwissProt for ANXA2R Gene:

Tissue specificity: Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4(+) and CD8(+) T-cells.
genes like me logo Genes that share expression patterns with ANXA2R: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ANXA2R Gene

Orthologs for ANXA2R Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ANXA2R Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANXA2R 34 35
  • 99.48 (n)
Species where no ortholog for ANXA2R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANXA2R Gene

Gene Tree for ANXA2R (if available)
Gene Tree for ANXA2R (if available)

Paralogs for ANXA2R Gene Pseudogenes for ANXA2R Gene

genes like me logo Genes that share paralogs with ANXA2R: view

No data available for Paralogs for ANXA2R Gene

Variants for ANXA2R Gene

Sequence variations from dbSNP and Humsavar for ANXA2R Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1054428 -- 43,039,691(-) GCTCC(A/G)GCAGC intron-variant, reference, missense
rs10606611 -- 43,041,501(+) AAAAC(-/TG)AGACA intron-variant, upstream-variant-2KB
rs10971 -- 43,039,491(-) GTTCA(C/T)GGATC intron-variant, reference, missense
rs111250888 -- 43,041,030(+) ATACC(A/T)GCGAG intron-variant, upstream-variant-2KB
rs111855014 -- 43,040,936(+) GAAAA(C/T)GCCCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ANXA2R Gene

Variant ID Type Subtype PubMed ID
nsv597925 CNV gain 21841781
nsv462126 CNV gain 19166990
nsv1029288 CNV loss 25217958

Variation tolerance for ANXA2R Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANXA2R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA2R Gene

Disorders for ANXA2R Gene

Relevant External Links for ANXA2R

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANXA2R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA2R Gene

Publications for ANXA2R Gene

  1. Cloning and characterization of the annexin II receptor on human marrow stromal cells. (PMID: 16895901) Lu G. … Roodman G.D. (J. Biol. Chem. 2006) 2 3 4 22 64
  2. Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer. (PMID: 18636554) Shiozawa Y. … Taichman R.S. (J. Cell. Biochem. 2008) 2 3 22 64
  3. Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures. (PMID: 10359570) Menaa C. … Roodman G.D. (J. Clin. Invest. 1999) 3 4 64
  4. SiRNA directed against annexin II receptor inhibits angiogenesis via suppressing MMP2 and MMP9 expression. (PMID: 25633185) Song H. … Zhao S. (Cell. Physiol. Biochem. 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for ANXA2R Gene

Sources for ANXA2R Gene

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