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Aliases for ANXA2P2 Gene

Aliases for ANXA2P2 Gene

  • Annexin A2 Pseudogene 2 2 3 4
  • ANX2L2 3 4
  • ANX2P2 3 4
  • LPC2B 3 4
  • Annexin II (Lipocortin II) Pseudogene 2 3
  • Lipocortin II Pseudogene 4

External Ids for ANXA2P2 Gene

Previous Symbols for ANXA2P2 Gene

  • ANX2P2
  • ANX2L2
  • LPC2B

Summaries for ANXA2P2 Gene

GeneCards Summary for ANXA2P2 Gene

ANXA2P2 (Annexin A2 Pseudogene 2) is a Pseudogene. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding.

UniProtKB/Swiss-Prot for ANXA2P2 Gene

  • Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA2P2 Gene

Genomics for ANXA2P2 Gene

Genomic Location for ANXA2P2 Gene

Start:
33,624,225 bp from pter
End:
33,625,534 bp from pter
Size:
1,310 bases
Orientation:
Plus strand

Genomic View for ANXA2P2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANXA2P2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA2P2 Gene

Regulatory Elements for ANXA2P2 Gene

Proteins for ANXA2P2 Gene

  • Protein details for ANXA2P2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMY6-AXA2L_HUMAN
    Recommended name:
    Putative annexin A2-like protein
    Protein Accession:
    A6NMY6
    Secondary Accessions:

    Protein attributes for ANXA2P2 Gene

    Size:
    339 amino acids
    Molecular mass:
    38659 Da
    Quaternary structure:
    • Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2P2/p36.
    Miscellaneous:
    • It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

neXtProt entry for ANXA2P2 Gene

Proteomics data for ANXA2P2 Gene at MOPED

Post-translational modifications for ANXA2P2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ANXA2P2 Gene

Domains for ANXA2P2 Gene

Protein Domains for ANXA2P2 Gene

UniProtKB/Swiss-Prot:

AXA2L_HUMAN
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.:
    • A6NMY6
Family:
  • Belongs to the annexin family.:
    • A6NMY6
Similarity:
  • Contains 4 annexin repeats.:
    • A6NMY6
genes like me logo Genes that share domains with ANXA2P2: view

No data available for Gene Families for ANXA2P2 Gene

Function for ANXA2P2 Gene

Molecular function for ANXA2P2 Gene

GENATLAS Biochemistry: annexin A2,pseudogene 2
UniProtKB/Swiss-Prot Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

Gene Ontology (GO) - Molecular Function for ANXA2P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005544 calcium-dependent phospholipid binding IEA --
GO:0008092 cytoskeletal protein binding IEA --
genes like me logo Genes that share ontologies with ANXA2P2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ANXA2P2 Gene

Localization for ANXA2P2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA2P2 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. In melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ANXA2P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
GO:0042470 melanosome IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ANXA2P2: view

Pathways for ANXA2P2 Gene

SuperPathways for ANXA2P2 Gene

No Data Available

Interacting Proteins for ANXA2P2 Gene

Selected Interacting proteins: A6NMY6-AXA2L_HUMAN for ANXA2P2 Gene via I2D

Gene Ontology (GO) - Biological Process for ANXA2P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with ANXA2P2: view

No data available for Pathways by source for ANXA2P2 Gene

Compounds for ANXA2P2 Gene

(1) HMDB Compounds for ANXA2P2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with ANXA2P2: view

Transcripts for ANXA2P2 Gene

mRNA/cDNA for ANXA2P2 Gene

(2) Additional mRNA sequences :
(417) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANXA2P2 Gene

Annexin A2 pseudogene 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA2P2 Gene

No ASD Table

Relevant External Links for ANXA2P2 Gene

GeneLoc Exon Structure for
ANXA2P2
ECgene alternative splicing isoforms for
ANXA2P2

Expression for ANXA2P2 Gene

mRNA expression in normal human tissues for ANXA2P2 Gene

mRNA differential expression in normal tissues according to GTEx for ANXA2P2 Gene

This gene is overexpressed in Esophagus - Mucosa (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ANXA2P2 Gene

SOURCE GeneReport for Unigene cluster for ANXA2P2 Gene Hs.534301

genes like me logo Genes that share expressions with ANXA2P2: view

Orthologs for ANXA2P2 Gene

Evolution for ANXA2P2 Gene

ENSEMBL:
Gene Tree for ANXA2P2 (if available)
TreeFam:
Gene Tree for ANXA2P2 (if available)

No data available for Orthologs for ANXA2P2 Gene

Paralogs for ANXA2P2 Gene

Selected SIMAP similar genes for ANXA2P2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANXA2P2: view

No data available for Paralogs for ANXA2P2 Gene

Variants for ANXA2P2 Gene

Sequence variations from dbSNP and Humsavar for ANXA2P2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs855520 -- 33,623,055(+) atact(C/G)agttg upstream-variant-2KB
rs855521 -- 33,623,820(+) ATATA(C/G)AGTTT upstream-variant-2KB
rs855522 -- 33,624,099(+) GGCAG(G/T)CCGAG upstream-variant-2KB
rs855523 -- 33,624,431(+) GGATG(A/C)GGTCA nc-transcript-variant
rs855524 -- 33,625,407(+) CCCAG(C/T)TAGTC nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA2P2 Gene

Variant ID Type Subtype PubMed ID
nsv471653 CNV Gain 15918152
nsv893026 CNV Gain 21882294

Relevant External Links for ANXA2P2 Gene

HapMap Linkage Disequilibrium report
ANXA2P2

Disorders for ANXA2P2 Gene

No disorders were found for ANXA2P2 Gene.

No data available for UniProtKB/Swiss-Prot for ANXA2P2 Gene

Publications for ANXA2P2 Gene

  1. Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication. (PMID: 2174397) Spano F. … Melli M. (Gene 1990) 3 4
  2. Chromosomal localization of the human genes for lipocortin I and lipocortin II. (PMID: 2969496) Huebner K. … Wallner B.P. (Oncogene Res. 1988) 2 3
  3. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  4. Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma. (PMID: 20000738) Yang X. … Chen X. (J. Proteome Res. 2010) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for ANXA2P2 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate ANXA2P2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ANXA2P2
    • Block miRNA regulation of ANXA2P2 using miScript Target Protectors

    Sources for ANXA2P2 Gene

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