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Aliases for ANXA2P2 Gene

Aliases for ANXA2P2 Gene

  • Annexin A2 Pseudogene 2 2 3 4 5
  • ANX2L2 3 4
  • ANX2P2 3 4
  • LPC2B 3 4
  • Annexin II (Lipocortin II) Pseudogene 2 3
  • Lipocortin II Pseudogene 4

External Ids for ANXA2P2 Gene

Previous HGNC Symbols for ANXA2P2 Gene

  • ANX2P2
  • ANX2L2
  • LPC2B

Previous GeneCards Identifiers for ANXA2P2 Gene

  • GC09P033936
  • GC09U900026
  • GC09P033614
  • GC09P033582
  • GC09P033627
  • GC09P033632
  • GC09P033706
  • GC09P033743
  • GC09P033780
  • GC09P033819
  • GC09P033830
  • GC09P033876

Summaries for ANXA2P2 Gene

GeneCards Summary for ANXA2P2 Gene

ANXA2P2 (Annexin A2 Pseudogene 2) is a Pseudogene. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding.

UniProtKB/Swiss-Prot for ANXA2P2 Gene

  • Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA2P2 Gene

Genomics for ANXA2P2 Gene

Regulatory Elements for ANXA2P2 Gene

Genomic Location for ANXA2P2 Gene

Chromosome:
9
Start:
33,624,225 bp from pter
End:
33,625,534 bp from pter
Size:
1,310 bases
Orientation:
Plus strand

Genomic View for ANXA2P2 Gene

Genes around ANXA2P2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA2P2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA2P2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA2P2 Gene

Proteins for ANXA2P2 Gene

  • Protein details for ANXA2P2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMY6-AXA2L_HUMAN
    Recommended name:
    Putative annexin A2-like protein
    Protein Accession:
    A6NMY6

    Protein attributes for ANXA2P2 Gene

    Size:
    339 amino acids
    Molecular mass:
    38659 Da
    Quaternary structure:
    • Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2P2/p36.
    Miscellaneous:
    • It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

neXtProt entry for ANXA2P2 Gene

Proteomics data for ANXA2P2 Gene at MOPED

Post-translational modifications for ANXA2P2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ANXA2P2 Gene

Domains & Families for ANXA2P2 Gene

Protein Domains for ANXA2P2 Gene

Suggested Antigen Peptide Sequences for ANXA2P2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMY6

UniProtKB/Swiss-Prot:

AXA2L_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
Similarity:
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA2P2: view

No data available for Gene Families for ANXA2P2 Gene

Function for ANXA2P2 Gene

Molecular function for ANXA2P2 Gene

GENATLAS Biochemistry:
annexin A2,pseudogene 2
UniProtKB/Swiss-Prot Function:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

Gene Ontology (GO) - Molecular Function for ANXA2P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity IEA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with ANXA2P2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ANXA2P2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANXA2P2 Gene

Localization for ANXA2P2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA2P2 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. In melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ANXA2P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
genes like me logo Genes that share ontologies with ANXA2P2: view

No data available for Subcellular locations from COMPARTMENTS for ANXA2P2 Gene

Pathways & Interactions for ANXA2P2 Gene

SuperPathways for ANXA2P2 Gene

No Data Available

Interacting Proteins for ANXA2P2 Gene

Selected Interacting proteins: A6NMY6-AXA2L_HUMAN for ANXA2P2 Gene via I2D

Gene Ontology (GO) - Biological Process for ANXA2P2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANXA2P2 Gene

Drugs & Compounds for ANXA2P2 Gene

(1) Drugs for ANXA2P2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ANXA2P2: view

Transcripts for ANXA2P2 Gene

mRNA/cDNA for ANXA2P2 Gene

(2) Additional mRNA sequences :
(417) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANXA2P2 Gene

Annexin A2 pseudogene 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA2P2 Gene

No ASD Table

Relevant External Links for ANXA2P2 Gene

GeneLoc Exon Structure for
ANXA2P2
ECgene alternative splicing isoforms for
ANXA2P2

Expression for ANXA2P2 Gene

mRNA expression in normal human tissues for ANXA2P2 Gene

mRNA differential expression in normal tissues according to GTEx for ANXA2P2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.9).

Protein differential expression in normal tissues from HIPED for ANXA2P2 Gene

This gene is overexpressed in Lavage (39.8) and Urine (27.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ANXA2P2 Gene



SOURCE GeneReport for Unigene cluster for ANXA2P2 Gene Hs.534301

genes like me logo Genes that share expression patterns with ANXA2P2: view

Protein tissue co-expression partners for ANXA2P2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ANXA2P2 Gene

Orthologs for ANXA2P2 Gene

Evolution for ANXA2P2 Gene

ENSEMBL:
Gene Tree for ANXA2P2 (if available)
TreeFam:
Gene Tree for ANXA2P2 (if available)

No data available for Orthologs for ANXA2P2 Gene

Paralogs for ANXA2P2 Gene

(15) SIMAP similar genes for ANXA2P2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANXA2P2: view

No data available for Paralogs for ANXA2P2 Gene

Variants for ANXA2P2 Gene

Sequence variations from dbSNP and Humsavar for ANXA2P2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs855523 -- 33,624,431(+) GGATG(A/C)GGTCA nc-transcript-variant
rs855524 -- 33,625,407(+) CCCAG(C/T)TAGTC nc-transcript-variant
rs10814015 -- 33,623,175(+) GTATA(C/G)ATTCC upstream-variant-2KB
rs10626168 -- 33,623,308(+) GAGTA(-/CTC)CTCTT upstream-variant-2KB
rs10758216 -- 33,625,084(+) ATTTT(C/G)CTGAT nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA2P2 Gene

Variant ID Type Subtype PubMed ID
nsv471653 CNV Gain 15918152
nsv893026 CNV Gain 21882294

Relevant External Links for ANXA2P2 Gene

HapMap Linkage Disequilibrium report
ANXA2P2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ANXA2P2 Gene

Disorders for ANXA2P2 Gene

Relevant External Links for ANXA2P2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANXA2P2

No disorders were found for ANXA2P2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA2P2 Gene

Publications for ANXA2P2 Gene

  1. Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication. (PMID: 2174397) Spano F. … Melli M. (Gene 1990) 3 4 67
  2. Chromosomal localization of the human genes for lipocortin I and lipocortin II. (PMID: 2969496) Huebner K. … Wallner B.P. (Oncogene Res. 1988) 2 3
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  4. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3
  5. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PMID: 23184937) Xie Y. … Cong F. (J. Biol. Chem. 2013) 3

Products for ANXA2P2 Gene

Sources for ANXA2P2 Gene

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