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ANXA2P2 Gene

pseudogene   GIFtS: 31
GCID: GC09P033819

Annexin A2 Pseudogene 2


(Previous symbols: ANX2P2, ANX2L2, LPC2B)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Annexin A2 Pseudogene 21 2 3
ANX2L21 2 3
ANX2P21 2 3
LPC2B1 2 3
Lipocortin II Pseudogene3

External Ids:    HGNC: 5391   Entrez Gene: 3042   Ensembl: ENSG000002319917   UniProtKB: A6NMY63   

Export aliases for ANXA2P2 gene to outside databases

Previous GC identifers: GC09P033936 GC09U900026 GC09P033614 GC09P033582 GC09P033627 GC09P033632 GC09P033706 GC09P033743 GC09P033780


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANXA2P2 Gene:
ANXA2P2 (annexin A2 pseudogene 2) is a pseudogene. Diseases associated with ANXA2P2 include hepatocellular carcinoma. GO annotations related to this gene include calcium-dependent phospholipid binding and calcium ion binding.

UniProtKB/Swiss-Prot: AXA2L_HUMAN, A6NMY6
Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic
phospholipids (By similarity). It binds two calcium ions with high affinity (By similarity). May be involved in
heat-stress response (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANXA2P2 gene promoter:
         AML1a   HTF   Pax-2a   Tal-1beta   E47   Max   AREB6   Pax-2b   Zic3   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANXA2P2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

ANXA2P2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA2P2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P033819:  view genomic region     (about GC identifiers)

Start:
33,624,223 bp from pter      End:
33,625,532 bp from pter
Size:
1,310 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AXA2L_HUMAN, A6NMY6 (See protein sequence)
Recommended Name: Putative annexin A2-like protein  
Size: 339 amino acids; 38659 Da
Subunit: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2P2/p36 (By similarity)
Miscellaneous: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved
with exocytosis (By similarity)
Caution: Could be the product of a pseudogene. The existence of a transcript at this locus is supported by only
one sequence submission (PubMed:2174397)

Explore the universe of human proteins at neXtProt for ANXA2P2: NX_A6NMY6

Explore proteomics data for ANXA2P2 at MOPED


See ANXA2P2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR002389 AnnexinII
 IPR018502 Annexin_repeat
 IPR001464 Annexin
 IPR018252 Annexin_repeat_CS

Graphical View of Domain Structure for InterPro Entry A6NMY6

ProtoNet protein and cluster: A6NMY6

UniProtKB/Swiss-Prot: AXA2L_HUMAN, A6NMY6
Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid (By similarity)
Similarity: Belongs to the annexin family
Similarity: Contains 4 annexin repeats


ANXA2P2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: AXA2L_HUMAN, A6NMY6
Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic
phospholipids (By similarity). It binds two calcium ions with high affinity (By similarity). May be involved in
heat-stress response (By similarity)

     Genatlas biochemistry entry for ANXA2P2:
annexin A2,pseudogene 2

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004859phospholipase inhibitor activity IEA--
GO:0005509calcium ion binding IEA--
GO:0005544calcium-dependent phospholipid binding IEA--
GO:0008092cytoskeletal protein binding IEA--
     
ANXA2P2 for ontologies           About GeneDecksing


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
AXA2L_HUMAN, A6NMY6: Secreted, extracellular space, extracellular matrix, basement membrane (By similarity).
Melanosome (By similarity). Note=In the lamina beneath the plasma membrane (By similarity). In melanosome
fractions from stage I to stage IV (By similarity). Translocated from the cytoplasm to the cell surface through a
Golgi-independent mechanism (By similarity)

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005604basement membrane IEA--
GO:0042470melanosome IEA--

ANXA2P2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANXA2P2
Interactions:

    Search GeneGlobe Interaction Network for ANXA2P2

5 Interacting proteins for ANXA2P2 (A6NMY63) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ESR1P033723I2D: score=1 
GABARAPL1Q9H0R83I2D: score=1 
H2AFXP161043I2D: score=1 
USP1O947823I2D: score=1 
USP53Q70EK83I2D: score=1 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ANXA2P2 (AXA2L)

1 HMDB Compound for ANXA2P2    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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Unigene Cluster for ANXA2P2:

Annexin A2 pseudogene 2
Hs.534301  [show with all ESTs]
Unigene Representative Sequence: BF670622
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000435128 ENST00000426153(uc010mjx.3)
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Additional mRNA sequence: 

M62898.1 NR_003573.1 

Selected DOTS entries (see all 58):

DT.100892145  DT.91783755  DT.100892113  DT.91783708  DT.95209548  DT.91648997  DT.95163829  DT.101987435 
DT.91868264  DT.75199496  DT.121072008  DT.100892173  DT.100892107  DT.91783683  DT.100892123  DT.100892182 
DT.100892108  DT.95102229  DT.100892134  DT.100892167  DT.95163908  DT.100892156  DT.121150047  DT.100892110 

Selected AceView cDNA sequences (see all 417):

BM846945 AA304360 AA302389 BQ934905 BQ947053 BU168537 BQ894885 BG748806 
BQ923753 BI857443 BE901729 BM049462 BM018827 BU856199 BQ919128 AL545662 
BQ953823 BG482160 BG752657 BQ937540 BU528366 BQ953752 BQ688454 BI870372 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ANXA2P2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ANXA2P2 Expression
About this image

ANXA2P2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ANXA2P2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.534301
    Custom PCR Arrays for ANXA2P2
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA2P2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for ANXA2P2 (if available)
TreeFam Gene Tree for ANXA2P2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ANXA2P2 gene
15 SIMAP similar genes for ANXA2P2 using alignment to 1 protein entry:     AXA2L_HUMAN:
ANXA2    DKFZp686H02120    ANXA1    ANXA5    ANXA8L2    ANXA13
ANXA4    ANXA11    ANXA3    ANXA6    ANXA9    ANXA7
ANXA8    ANXA10    ANXA8L1

ANXA2P2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ANXA2P2 (see all 99)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1857542911,2
--33622499(+) ATACCA/TTACAT 1 -- us2k10--------
rs1411083091,2
--33622534(+) TGGGAC/TGAGGG 1 -- us2k10--------
rs800654911,2
C,F--33622666(+) AGGTCG/AGTGAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1498120781,2
--33622670(+) CGGTGA/GGTACA 1 -- us2k10--------
rs1886163341,2
--33622879(+) GCAGGG/TAAGAC 1 -- us2k10--------
rs1931584621,2
--33622905(+) CCCTCC/TTAGGG 1 -- us2k10--------
rs8555201,2
C,F,A,H--33623053(+) atactC/Gagttg 1 -- us2k119Minor allele frequency- G:0.45NS EA NA WA CSA 934
rs1458172351,2
--33623058(+) CAGTTG/TGGCAA 1 -- us2k10--------
rs1842986371,2
--33623100(+) GGCTTG/TGGCTA 1 -- us2k10--------
rs108140151,2
C,F,A,H--33623173(+) GTATAG/CATTCC 1 -- us2k114Minor allele frequency- C:0.29NS EA NA WA CSA 784

HapMap Linkage Disequilibrium report for ANXA2P2 (33624223 - 33625532 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ANXA2P2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv893026CNV Gain21882294
nsv471653CNV Gain15918152

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for ANXA2P2:    
About MalaCards
hepatocellular carcinoma


ANXA2P2 for disorders           About GeneDecksing


Export disorders for ANXA2P2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ANXA2P2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ANXA2P2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication. (PubMed id 2174397)1, 2 Spano F.... Melli M. (Gene 1990)
  2. Chromosomal localization of the human genes for lipocortin I and lipocortin II. (PubMed id 2969496)1, 3 Huebner K....Wallner B.P. (Oncogene Res. 1988)
  3. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  5. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (J. Biol. Chem. 2011)
  6. Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma. (PubMed id 20000738)1 Yang X....Chen X. (J. Proteome Res. 2010)
  7. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
  8. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
  9. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 304 HGNC: 539 AceView: ANXA2P2 Ensembl:ENSG00000231991 euGenes: HUgn304
ECgene: ANXA2P2 H-InvDB: ANXA2P2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ANXA2P2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ANXA2P2 gene:
Search GeneIP for patents involving ANXA2P2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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