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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANXA2P2 Gene

pseudogene   GIFtS: 33
GCID: GC09P033780

Annexin A2 Pseudogene 2


(Previous symbols: ANX2P2, ANX2L2, LPC2B)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Annexin A2 Pseudogene 21 2 3
ANX2L21 2 3
ANX2P21 2 3
LPC2B1 2 3
Lipocortin II Pseudogene3

External Ids:    HGNC: 5391   Entrez Gene: 3042   Ensembl: ENSG000002319917   UniProtKB: A6NMY63   
ORGUL members:         
NONCODE14:n406145      

Export aliases for ANXA2P2 gene to outside databases

Previous GC identifers: GC09P033936 GC09U900026 GC09P033614 GC09P033582 GC09P033627 GC09P033632 GC09P033706 GC09P033743


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ANXA2P2 Gene: 
ANXA2P2 (annexin A2 pseudogene 2) is a pseudogene, and is affiliated with the lncRNA class. Diseases associated with ANXA2P2 include hepatocellular carcinoma. GO annotations related to this gene include calcium-dependent phospholipid binding and calcium ion binding.

UniProtKB/Swiss-Prot: AXA2L_HUMAN, A6NMY6
Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic
phospholipids (By similarity). It binds two calcium ions with high affinity (By similarity). May be involved in
heat-stress response (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANXA2P2 gene promoter:
         AML1a   HTF   Pax-2a   Tal-1beta   E47   Max   AREB6   Pax-2b   Zic3   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ANXA2P2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA2P2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

ANXA2P2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA2P2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P033780:  view genomic region     (about GC identifiers)

Start:
33,624,223 bp from pter      End:
33,625,532 bp from pter
Size:
1,310 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AXA2L_HUMAN, A6NMY6 (See protein sequence)
Recommended Name: Putative annexin A2-like protein  
Size: 339 amino acids; 38659 Da
Subunit: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2P2/p36 (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane (By similarity).
Melanosome (By similarity). Note=In the lamina beneath the plasma membrane (By similarity). In melanosome
fractions from stage I to stage IV (By similarity). Translocated from the cytoplasm to the cell surface through a
Golgi-independent mechanism (By similarity)
Miscellaneous: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved
with exocytosis (By similarity)
Caution: Could be the product of a pseudogene. The existence of a transcript at this locus is supported by only
one sequence submission (PubMed:2174397)

Explore the universe of human proteins at neXtProt for ANXA2P2: NX_A6NMY6

Explore proteomics data for ANXA2P2 at MOPED 

ANXA2P2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ANXA2P2 Protein Expression

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005604basement membrane IEA--
GO:0042470melanosome IEA--

ANXA2P2 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR002389 AnnexinII
 IPR001464 Annexin
 IPR018252 Annexin_repeat_CS
 IPR018502 Annexin_repeat

Graphical View of Domain Structure for InterPro Entry A6NMY6

ProtoNet protein and cluster: A6NMY6

UniProtKB/Swiss-Prot: AXA2L_HUMAN, A6NMY6
Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid (By similarity)
Similarity: Belongs to the annexin family
Similarity: Contains 4 annexin repeats


ANXA2P2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: AXA2L_HUMAN, A6NMY6
Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic
phospholipids (By similarity). It binds two calcium ions with high affinity (By similarity). May be involved in
heat-stress response (By similarity)

     Genatlas biochemistry entry for ANXA2P2:
annexin A2,pseudogene 2

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004859phospholipase inhibitor activity IEA--
GO:0005509calcium ion binding IEA--
GO:0005544calcium-dependent phospholipid binding IEA--
GO:0008092cytoskeletal protein binding IEA--
     
ANXA2P2 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANXA2P2

5 Interacting proteins for ANXA2P2 (A6NMY63) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ESR1P033723I2D: score=1 
GABARAPL1Q9H0R83I2D: score=1 
H2AFXP161043I2D: score=1 
USP1O947823I2D: score=1 
USP53Q70EK83I2D: score=1 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for ANXA2P2 (AXA2L)

1 HMDB Compound for ANXA2P2    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

Search CenterWatch for drugs/clinical trials and news about ANXA2P2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for ANXA2P2:

Annexin A2 pseudogene 2
Hs.534301  [show with all ESTs]
Unigene Representative Sequence: BF670622
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000435128 ENST00000426153(uc010mjx.3)
miRNA
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Additional mRNA sequence: 

M62898.1 NR_003573.1 

24/58 DOTS entries (see all 58):

DT.100892145  DT.91783755  DT.100892113  DT.91783708  DT.95209548  DT.91648997  DT.95163829  DT.101987435 
DT.91868264  DT.75199496  DT.121072008  DT.100892173  DT.100892107  DT.91783683  DT.100892123  DT.100892182 
DT.100892108  DT.95102229  DT.100892134  DT.100892167  DT.95163908  DT.100892156  DT.121150047  DT.100892110 

24/417 AceView cDNA sequences (see all 417):

AA302389 AA304360 BM846945 BG769862 BQ953823 BX446532 BQ934905 BU168537 
BM833397 BM049462 BE901729 BQ227590 BQ671699 BU180386 BQ923753 BQ894885 
BQ947053 BM018827 BI857443 BG748806 BQ919128 CD513935 BQ219360 BM832278 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANXA2P2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ANXA2P2 Expression
About this image


See ANXA2P2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANXA2P2

SOURCE GeneReport for Unigene cluster: Hs.534301
    SABiosciences Custom PCR Arrays for ANXA2P2
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for ANXA2P2 (if available)
TreeFam Gene Tree for ANXA2P2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ANXA2P2 gene
15 SIMAP similar genes for ANXA2P2 using alignment to 1 protein entry:     AXA2L_HUMAN:
ANXA2    DKFZp686H02120    ANXA1    ANXA5    ANXA8L2    ANXA13
ANXA4    ANXA11    ANXA3    ANXA6    ANXA9    ANXA7
ANXA8L1    ANXA10    ANXA8

ANXA2P2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/99 SNPs in ANXA2P2 are shown (see all 99)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1857542911,2
--33622499(+) ATACCA/TTACAT 1 -- us2k10--------
rs1411083091,2
--33622534(+) TGGGAC/TGAGGG 1 -- us2k10--------
rs800654911,2
C,F--33622666(+) AGGTCG/AGTGAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1498120781,2
--33622670(+) CGGTGA/GGTACA 1 -- us2k10--------
rs1886163341,2
--33622879(+) GCAGGG/TAAGAC 1 -- us2k10--------
rs1931584621,2
--33622905(+) CCCTCC/TTAGGG 1 -- us2k10--------
rs8555201,2
C,F,A,H--33623053(+) atactC/Gagttg 1 -- us2k119Minor allele frequency- G:0.45NS EA NA WA CSA 934
rs1458172351,2
--33623058(+) CAGTTG/TGGCAA 1 -- us2k10--------
rs1842986371,2
--33623100(+) GGCTTG/TGGCTA 1 -- us2k10--------
rs108140151,2
C,F,A,H--33623173(+) GTATAG/CATTCC 1 -- us2k114Minor allele frequency- C:0.29NS EA NA WA CSA 784

HapMap Linkage Disequilibrium report for ANXA2P2 (33624223 - 33625532 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ANXA2P2:    About this table     
Variant IDTypeSubtypePubMed ID
nsv893026CNV Gain21882294
nsv471653CNV Gain15918152

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for ANXA2P2:    About MalaCards
hepatocellular carcinoma    


ANXA2P2 for disorders           About GeneDecksing


Export disorders for ANXA2P2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ANXA2P2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANXA2P2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication. (PubMed id 2174397)1, 2 Spano F.... Melli M. (1990)
  2. Chromosomal localization of the human genes for lipocortin I and lipocortin II. (PubMed id 2969496)1, 3 Huebner K....Wallner B.P. (1988)
  3. Deubiquitinase FAM/USP9X interacts with the E3 ubiquit in ligase SMURF1 protein and protects it from ligase activity-dependent self-deg radation. (PubMed id 23184937)1 Xie Y....Cong F. (2013)
  4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
  5. The BTB and CNC homology 1 (BACH1) target genes are i nvolved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (2011)
  6. Proteomic dissection of cell type-specific H2AX-inter acting protein complex associated with hepatocellular carcinoma. (PubMed id 20000738)1 Yang X....Chen X. (2010)
  7. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
  8. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
  9. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 304 HGNC: 539 AceView: ANXA2P2 Ensembl:ENSG00000231991 euGenes: HUgn304
ECgene: ANXA2P2 H-InvDB: ANXA2P2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ANXA2P2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ANXA2P2 gene:
Search GeneIP for patents involving ANXA2P2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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