ANXA2P2 Gene
pseudogene GIFtS: 33
GCID: GC09P033743
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annexin A2 pseudogene 2
(Previous symbols: ANX2P2, ANX2L2, LPC2B)
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Aliases
for ANXA2P2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| Annexin A2 Pseudogene 21 2 3 | | ANX2L21 2 3 | | ANX2P21 2 3 | | LPC2B1 2 3 | | Lipocortin II Pseudogene3 |
| External Ids: | HGNC: 5391 | Entrez Gene: 3042 | Ensembl: ENSG000002319917 | UniProtKB: A6NMY63 | | ORGUL members: | |
|---|
| NONCODE:n406145 | |
Export aliases for ANXA2P2 gene to outside databasesPrevious GC identifers: GC09P033936 GC09U900026 GC09P033614 GC09P033582 GC09P033627 GC09P033632 GC09P033706
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Summaries
for ANXA2P2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AXA2L_HUMAN, A6NMY6Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionicphospholipids (By similarity). It binds two calcium ions with high affinity (By similarity). May be involved inheat-stress response (By similarity)
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Genomic Views
for ANXA2P2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANXA2P2 gene promoter:
AML1a HTF Pax-2a Tal-1beta E47 Max AREB6 Pax-2b Zic3 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANXA2P2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA2P2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13.3ANXA2P2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P033743: view genomic region
(about GC identifiers)
Start:
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33,624,223 bp from pter |
End:
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33,625,532 bp from pter |
Size:
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1,310 bases |
Orientation:
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plus strand |
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Proteins
for ANXA2P2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: AXA2L_HUMAN, A6NMY6 (See
protein sequence)Recommended Name: Putative annexin A2-like protein Size: 339 amino acids; 38659 Da
Subunit: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2P2/p36 (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane (By similarity).Melanosome (By similarity). Note=In the lamina beneath the plasma membrane (By similarity). In melanosome fractionsfrom stage I to stage IV (By similarity). Translocated from the cytoplasm to the cell surface through aGolgi-independent mechanism (By similarity)
Miscellaneous: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved withexocytosis (By similarity)
Caution: Could be the product of a pseudogene. The existence of a transcript at this locus is supported by only onesequence submission (PubMed:2174397)Explore the universe of human proteins at neXtProt for ANXA2P2: NX_A6NMY6
ANXA2P2 Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ANXA2P2 for ontologies About GeneDecksing
ANXA2P2 Antibody Products:
Assay Products for ANXA2P2: |
Protein
Domains /
Families
for ANXA2P2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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ANXA2P2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NMY6ProtoNet protein and cluster: A6NMY6 UniProtKB/Swiss-Prot: AXA2L_HUMAN, A6NMY6Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid (By similarity)Similarity: Belongs to the annexin familySimilarity: Contains 4 annexin repeats |
Function
for ANXA2P2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: AXA2L_HUMAN, A6NMY6Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionicphospholipids (By similarity). It binds two calcium ions with high affinity (By similarity). May be involved inheat-stress response (By similarity) Genatlas biochemistry entry for ANXA2P2:annexin A2,pseudogene 2
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004859 | phospholipase inhibitor activity |
IEA | -- | | GO:0005509 | calcium ion binding |
IEA | -- | | GO:0005544 | calcium-dependent phospholipid binding |
IEA | -- | | GO:0008092 | cytoskeletal protein binding |
IEA | -- |
ANXA2P2 for ontologies About GeneDecksing
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Pathways & Interactions
for ANXA2P2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANXA2P2
5 Interacting proteins for ANXA2P2 (A6NMY63) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for ANXA2P2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for ANXA2P2
1 HMDB Compound for ANXA2P2 About this table
Search CenterWatch for drugs/clinical trials and news about ANXA2P2 
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Transcripts
for ANXA2P2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Cluster for ANXA2P2: Annexin A2 pseudogene 2 Hs.534301 [show with all ESTs]Unigene Representative Sequence: BF6706222 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000435128 ENST00000426153(uc010mjx.3)
Additional cDNA sequence: M62898.1 NR_003573.1 24/58 DOTS entries (see all 58): DT.100892145 DT.91783755 DT.100892113 DT.91783708 DT.95209548 DT.91648997 DT.95163829 DT.101987435 DT.91868264 DT.75199496 DT.121072008 DT.100892173 DT.100892107 DT.91783683 DT.100892123 DT.100892182 DT.100892108 DT.95102229 DT.100892134 DT.100892167 DT.95163908 DT.100892156 DT.121150047 DT.100892110 24/417 AceView cDNA sequences (see all 417): BM846945 AA304360 AA302389 BQ671699 BG752657 BU543197 BE180873 BU527722 BG696310 BM472373 BI870372 BQ937540 BG746763 BQ073485 BU179345 BQ890634 BE274995 BQ953823 BI193430 BG475913 BQ931882 BU179790 CB120246 BQ896944
GeneLoc Exon Structure
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Expression
for ANXA2P2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANXA2P2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ANXA2P2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANXA2P2
SOURCE GeneReport for Unigene cluster: Hs.534301
SABiosciences Custom PCR Arrays for ANXA2P2
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANXA2P2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ANXA2P2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANXA2P2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANXA2P2 |
Orthologs
for ANXA2P2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for ANXA2P2 (if available)
TreeFam Gene Tree for ANXA2P2 (if available) |
Paralogs
for ANXA2P2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for ANXA2P2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for ANXA2P2 (33624223 - 33625532 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ANXA2P2
1 CNV: 0741 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for ANXA2P2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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ANXA2P2 for disorders About GeneDecksing
2  diseases for ANXA2P2: About MalaCardshepatocellular carcinoma carcinoma
Export disorders for ANXA2P2 gene to outside databases
|
Publications
for ANXA2P2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for ANXA2P2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANXA2P2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication. (PubMed id 2174397)1, 2 Spano F.... Melli M. (1990)
- Chromosomal localization of the human genes for lipocortin I and lipocortin II. (PubMed id 2969496)1, 3 Huebner K....Wallner B.P. (1988)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- The BTB and CNC homology 1 (BACH1) target genes are i nvolved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (2011)
- Proteomic dissection of cell type-specific H2AX-inter acting protein complex associated with hepatocellular carcinoma. (PubMed id 20000738)1 Yang X....Chen X. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
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External Searches for ANXA2P2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ANXA2P2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing ANXA2P2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANXA2P2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for ANXA2P2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ANXA2P2 gene:
Search GeneIP for patents involving ANXA2P2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANXA2P2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANXA2P2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANXA2P2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA2P2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANXA2P2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANXA2P2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANXA2P2 |
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 |  |  |  | |
| | | | Search Tocris compounds for ANXA2P2 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for ANXA2P2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANXA2P2 |
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