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ANXA2 Gene

protein-coding GIFtS: 71

GC15M058426

annexin A2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ANX2, ANX2L4, CAL1H, LPC2D)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ANX2 ^², ³
ANX2L4 ^², ³, ⁵
Annexin-2 ^³
CAL1H ^², ³
Chromobindin-8 ^³
LIP2 ^¹, ², ⁵
LPC2 ^²
LPC2D ^², ³, ⁵
OTTHUMP00000163650 ^²
P36 ^²
PAP-IV ^², ³
p36 ^³

Descriptions
Annexin II ^², ³
Calpactin I heavy chain ^³
Lipocortin II ^², ³
Placental anticoagulant protein IV ^², ³
Protein I ^³
annexin A2 ^²
calpactin I heavy polypeptide ^²
chromobindin 8 ^²

External Ids
HGNC: 537¹
Entrez Gene: 302²
UniProtKB: P07355³
Ensembl: ENSG00000182718⁷

Search outside databases for aliases for ANXA2 gene

Previous GC identifers: GC15M056197 GC15M053687 GC15M058218 GC15M058355

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ANXA2:

This gene encodes a member of the annexin family. Members of this calcium-dependent

phospholipid-binding protein family play a role in the regulation of cellular growth and in signal

transduction pathways. This protein functions as an autocrine factor which heightens osteoclast

formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10,

respectively. Multiple alternatively spliced transcript variants encoding different isoforms have

been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ANXA2_HUMAN, P07355

Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced

by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in

heat-stress response

Gene Wiki entry for ANXA2 (Annexin_A2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ANXA2 gene

Entrez Gene cytogenetic band: 15q21-q22 Ensembl cytogenetic band: 15q22.2 HGNC cytogenetic band: 15q22.2

ANXA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M058426: (about GC identifiers)

Start:	58,426,625 bp from pter
End:	58,477,477 bp from pter
Size:	50,853 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ANXA2_HUMAN, P07355 (See protein sequence)

Recommended Name: Annexin A2

Size: 339 amino acids; 38604 Da

Subunit: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.

Interacts with ATP1B1 and DYSF (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane.

Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in

melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface

through a Golgi-independent mechanism

Miscellaneous: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and

be involved with exocytosis

PDB structures from and Proteopedia :

1W7B (3D)

1XJL (3D)

2HYU (3D)

2HYV (3D)

2HYW (3D)

Secondary accessions: Q567R4 Q96DD5

Post-translational modifications:

Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001002857.1 NP_001002858.1 NP_001129487.1 NP_004030.1

ENSEMBL proteins:

ENSP00000379342 ENSP00000348640 ENSP00000346032

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Annexin II)
	Human Recombinant Proteins from Abnova (ANXA2)

OriGene Purified Recombinant Human Proteins (see all 2): ANXA2

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005604	basement membrane	IEA	--
GO:0005625	soluble fraction	TAS	7961821
GO:0005737	cytoplasm	IEA	--
GO:0005769	early endosome	IEA	--

About this table

Antibodies for ANXA2:

	Invitrogen Antibodies for ANXA2
	Millipore Mono- and Polyclonal Antibodies for the study of ANXA2
	Sigma-Aldrich Antibodies for ANXA2
	R&D Systems Antibodies for ANXA2 (Annexin A2)
	Antibodies from Abcam (Annexin II), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ANXA2)
	Novus Biologicals Antibodies for ANXA2

Assays for ANXA2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P07355

ProtoNet protein and cluster: P07355

2 Blocks protein families:

IPB001464 Annexin

IPB002389 Annexin type II signature

UniProtKB/Swiss-Prot: ANXA2_HUMAN, P07355

Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid

Similarity: Belongs to the annexin family

Similarity: Contains 4 annexin repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ANXA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ANXA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_004039

Applied Biosystems Silencer® siRNAs for ANXA2

Sigma-Aldrich siRNA for ANXA2

Sigma-Aldrich shRNA Panels and shRNA for ANXA2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ANXA2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001002857
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001002857
untagged cDNA clones in CMV expression vector (see all 4): NM_001002857

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001002858

UniProtKB/Swiss-Prot: ANXA2_HUMAN, P07355

Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced

by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in

heat-stress response

Genatlas biochemistry entry for ANXA2:

annexin A2,calcium and phospholipid binding protein,calpactin 1,involved in

exocytosis,overexpressed in small cell lung carcinoma

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Anxa2):

growth/size

hematopoietic system

homeostasis/metabolism

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004859	phospholipase inhibitor activity	TAS	3013422
GO:0005509	calcium ion binding	IEA	--
GO:0005544	calcium-dependent phospholipid binding	IEA	--
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IEA	--
GO:0008092	cytoskeletal protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ANXA2

5/56 Interacting proteins for ANXA2 (ENSP00000346032³ P07355^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 56 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPM1B	O75688¹	EBI-352622, EBI-1047039
MAP3K4	Q9Y6R4²	MINT-51382
YWHAZ	P63104²	MINT-3297866
S100A10	ENSP00000357799³	STRING (score=.998)
PLAT	ENSP00000220809³	STRING (score=.995)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	TAS	7961821
GO:0001525	angiogenesis	IEA	--
GO:0030199	collagen fibril organization	IEA	--
GO:0042730	fibrinolysis	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ANXA2
10/36 Novoseek chemical compound relationships for ANXA2 gene (see all 36 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phospholipid	59.21	35	12730231 (3), 8490575 (2), 9451817 (1), 14668336 (1) (see all 25)
calcium	45.75	94	7947730 (5), 11074597 (4), 9044052 (4), 16882661 (3) (see all 43)
pro-gastrin	40.88	3	17671195 (1)
tyrosine	39.88	30	18565825 (4), 16527271 (3), 9013554 (2), 19020748 (2) (see all 19)
glyceraldehyde 3-phosphate	32.05	8	7584597 (2), 1999197 (2), 17268060 (1), 19407367 (1) (see all 6)
lysine	27.03	4	11866428 (2), 7549065 (1), 16373665 (1)
digitonin	25.00	2	9188096 (1), 9188103 (1)
3-phosphoglycerate	22.81	1	1533225 (1)
cyanogen bromide	21.46	3	7584597 (2), 8117306 (1)
homocysteine	19.24	9	9545344 (3), 11074597 (1), 9677419 (1), 12208147 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ANXA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ANXA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_004039

Sigma-Aldrich siRNA for ANXA2

Sigma-Aldrich shRNA Panels and shRNA for ANXA2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001002857 NM_001002858 NM_001136015 NM_004039

REFSEQ mRNAs for ANXA2 gene (4 alternative transcripts):

NM_001002857.1 NM_001002858.2 NM_001136015.2 NM_004039.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001002857 NM_001002858 NM_001136015 NM_004039

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001002857
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001002857
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001002857

Additional cDNA sequence:

AK222542.1 AK297923.1 AK309356.1 BC001388.2 BC009564.1 BC013843.1 BC015834.1 BC016774.1

BC021114.1 BC023990.1 BC052558.1 BC052567.1 BC066955.1 BC068065.1 BC093056.1 BT007432.1

BX640598.1 CR590378.1 CR595032.1 CR595469.1 CR596938.1 CR597222.1 CR597904.1 CR598583.1

CR599823.1 CR600114.1 CR608031.1 CR611402.1 CR616100.1 CR616357.1 CR617962.1 CR618374.1

CR618857.1 CR620533.1 CR622642.1 CR622682.1 CR625736.1 D00017.1 D28364.1

24/101 DOTS entries (see all 101 ):

DT.91648997 DT.91783683 DT.100892145 DT.100892182 DT.95163829 DT.75199496 DT.100892123 DT.100892113

DT.91783755 DT.91783708 DT.95102229 DT.101987435 DT.95209548 DT.91783750 DT.100808780 DT.95325315

DT.91868264 DT.91783724 DT.95163951 DT.100892175 DT.91783792 DT.121072008 DT.100892108 DT.121072016

24/113 AceView cDNA sequences (see all 113 ):

AA535261 BE906789 CD617833 AA377302 AI934304 AA773066 AI277242 AA526177

AA770102 AA527148 CA420584 CD617851 AI718669 BF221946 F24513 AA570307

AW002699 F31768 H41145 BM854211 CD617848 H54330 AA372236 AA670446

highest scoring ESTs for ANXA2:

AI984166 BC001388 BC013843 BC023990 BC052567 BC066955 BC068065 BE730350 BI836982 BM741240

Unigene Cluster for ANXA2:

Annexin A2

Hs.511605 [show with all ESTs]

Unigene Representative Sequence: AK309356

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ANXA2 (see all 10 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17
SP1:									-		-		-		-		-				-						-
SP2:					-		-		-		-		-								-						-
SP3:									-		-		-		-		-				-
SP4:					-				-		-		-		-		-				-
SP5:

About this scheme

ECgene alternative splicing isoforms for ANXA2

3 Ensembl transcripts including schematic representations:

ENST00000396024 ENST00000356292 ENST00000332680

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ANXA2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ANXA2

¹ / ² / ³

12 probe-sets matching ANXA2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
757_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.65	D28364	0.80	1.00	0.91	1
68395_at²^{, 3}	U95-E	1	1.00	1.00	-0.21	0.55	N34481	0.80	1.00	0.91	1
58798_at²^{, 3}	U95-C	2	1.00	0.91	0.85	1.18	AI984166	0.80	1.00	0.91	1
769_s_at²^{, 3}	U95-A	3	1.00	0.33	0.97	1.30	D00017	0.80	0.67	0.74	1
31444_s_at²^{, 3}	U95-A	3	1.00	0.33	0.96	1.34	M62895	0.20	0.08	0.15	2
76043_at²^{, 3}	U95-E	1	0.62	1.00	0.87	1.01	AW015534	0.40	1.00	0.76	1
201590_x_at²^{, 3}	U133-A	5	1.00	0.58	--	--	NM_004039	0.40	0.67	0.55	1
210427_x_at²^{, 3}	U133-A	5	1.00	0.57	--	--	BC001388	0.80	1.00	0.91	1
213503_x_at²^{, 3}	U133-A	5	1.00	0.52	--	--	BE908217	0.40	1.00	0.76	1
201590_x_at²	U133Plus2	5	1.00	0.58	--	--	--	--	--	--	--
210427_x_at²	U133Plus2	5	1.00	0.57	--	--	--	--	--	--	--
213503_x_at²	U133Plus2	5	1.00	0.52	--	--	--	--	--	--	--

GeneDecks ANXA2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTCCAGCTA

SOURCE GeneReport for Unigene cluster: Hs.511605
Expression variation in blood from EXPOLDB for ANXA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ANXA2 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ANXA2¹	--	annexin A2	93.31(n) 98.82(a)	403435 NM_001002961.1 NP_001002961.1
chimpanzee (Pan troglodytes)	ANXA2¹	--	annexin A2	98.55(n) 99.13(a)	747018 XM_001155637.1 XP_001155637.1
cow (Bos taurus)	ANXA2¹	--	annexin A2	93.02(n) 98.23(a)	282689 NM_174716.1 NP_777141.1
rat (Rattus norvegicus)	Anxa2¹	--	annexin A2	89.58(n) 96.76(a)	56611 NM_019905.1 NP_063970.1
mouse (Mus musculus)	Anxa2^{1, 5}	9 (37.00 cM)⁵	annexin A2^{1, 5}	89.58(n)¹ 97.64(a)¹	12306¹ NM_007585.3¹ NP_031611.1¹ AK012563⁵ AK088645⁵ (see all 26)

About this table Species with no ortholog for ANXA2

ENSEMBL Gene Tree for ANXA2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ANXA2 gene

ANXA3² ANXA1²

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/366 NCBI SNPs in ANXA2 are shown (see all 366 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 115)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4775266^1,2	A,C	58478080(+)	`CCGAGC/GGCCAG`	3	--	ng3¹		0	--	--	--	--
--	rs11071527^1,2	A,C	58478730(+)	`tgtgtC/Gtgtgt`	3	--	ng3¹		0	--	--	--	--
--	rs3582^1,2	C,F	58426960(-)	`CTGGCC/TTTCCT`	4	--	ut3¹		1		MN	184
	rs6494195^1,2	C,H	58478224(+)	`CTCGTG/AGCAGG`	3	--	ng3¹		4		EU EA WA	416
	rs11553794^1,2	H	58443976(-)	`CCAACC/AGCAGC`	4	S/R	mis¹ ese³		4		EU EA WA	406
	rs28364623^1,2	F	58478187(-)	`AGAGAA/GGCGGA`	3	--	ng3¹		2		MN EA	1252
	rs17845226^1,2	C	58440497(+)	`AATCAA/CCGTCT`	4	V/L	mis¹ ese³		0	--	--	--	--
--	rs4775265^1,2	C	58477855(+)	`AGTGTC/TTTTTT`	3	--	ng3¹ trp³		0	--	--	--	--
--	rs12904657^1,2	F	58477381(+)	`TCTCCG/ACACCC`	3	C/C	syn¹ int¹ ese³		2		MN EA	1252
	rs2168013^1,2	A,C,F,H,O	58437340(+)	`AAATAC/TTAAAA`	3	--	int¹		16		EU EA WA NA	1412

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HapMap Linkage Disequilibrium images for ANXA2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 151740

10/57 Novoseek disease relationships for ANXA2 gene (see all 57 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
antiphospholipid syndrome	47.09	2	12627665 (1), 18827060 (1)
leukemia promyelocytic acute	46.77	8	11815288 (1), 11108960 (1), 15070701 (1), 10099141 (1) (see all 7)
pancreatic cancer	34.74	17	18712570 (6), 15194650 (3), 8269629 (3), 17456763 (3) (see all 6)
disseminated intravascular coagulation	29.70	2	18024623 (1), 16757074 (1)
tumors	21.07	84	18608216 (4), 19452941 (4), 18924133 (3), 7787249 (3) (see all 35)
carcinoma squamous cell	20.78	7	12921564 (2), 18822406 (1), 18262347 (1), 16051329 (1) (see all 6)
metastasis	18.79	16	18608216 (2), 16643892 (2), 18220793 (2), 18636554 (2) (see all 11)
cancer	18.78	27	18712570 (2), 9482108 (1), 14522961 (1), 16408090 (1) (see all 22)
coagulopathy	18.12	5	19285282 (1), 12513745 (1), 15567461 (1), 16757074 (1)
nonmetastatic	17.81	5	18924133 (1), 16643892 (1), 17205601 (1)

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1 PharmGKB disease relationship for ANXA2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Genetic Association Database: ANXA2
Human Genome Epidemiology Navigator: ANXA2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/456 PubMed articles for ANXA2 gene (see all 456 ):

The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha. (PubMed id 1825830)^{1, 3, 4} Jindal H.K.... Vishwanatha J.K. (1991)
The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein. (PubMed id 8636985)^{1, 3, 4} Burger A.... Weber K. (1996)
An endothelial cell-surface form of annexin II binds human cytomegalovirus. (PubMed id 8117306)^{1, 3, 4} Wright J.F.... Wasi S. (1994)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)^{3, 4} Zhang Y.... White F.M. (2005)
Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. (PubMed id 15784727)^{3, 6} Baldwin C....Steinberg M.H. (2005)
An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface. (PubMed id 15302870)^{3, 4} Deora A.B.... Hajjar K.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 302	HGNC: 537	AceView: ANXA2.1	Ensembl:ENSG00000182718	euGenes: HUgn302
ECgene: ANXA2	H-InvDB: ANXA2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ANXA2	Genetics and Cytogenetics in Oncology and Haematology
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt086.shtml

Licensable Technologies for ANXA2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ANXA2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ANXA2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ANXA2		Antibodies for ANXA2
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	Lentivirus-delivered shRNAs for ANXA2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (Annexin II)
	Antibodies (Annexin II)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for ANXA2

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ANXA2 Gene at Home site.
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ANXA2 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for ANXA2

Summaries
for ANXA2

Genomic Location
for ANXA2

Proteins
for ANXA2

Protein Domains/
Families
for ANXA2

Gene Function
for ANXA2

Pathways & Interactions
for ANXA2

Drugs & Compounds
for ANXA2

Transcripts
for ANXA2

Expression
for ANXA2

Orthologs
for ANXA2

Paralogs
for ANXA2

SNPs/Variants
for ANXA2

Disorders & Mutations
for ANXA2

Medical News
for ANXA2

Publications
for ANXA2

Search for ANXA2

Genome Databases showing ANXA2

Other Databases showing ANXA2

Specialized Databases showing ANXA2

Licensable Technologies
for ANXA2

Services
for ANXA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ANXA2 (Gene Symbol)
ANX2
ANX2L4
Annexin-2
CAL1H
Chromobindin-8
LIP2
LPC2
LPC2D
OTTHUMP00000163650
P36
PAP-IV
p36
Annexin II
Calpactin I heavy chain
Lipocortin II
Placental anticoagulant protein IV
Protein I
annexin A2
calpactin I heavy polypeptide
chromobindin 8

ANXA2 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor ANXA2

Summariesfor ANXA2

Genomic Locationfor ANXA2

Proteinsfor ANXA2

Protein Domains/Familiesfor ANXA2

Gene Functionfor ANXA2

Pathways & Interactionsfor ANXA2

Drugs & Compoundsfor ANXA2

Transcriptsfor ANXA2

Expression for ANXA2

Orthologsfor ANXA2

Paralogsfor ANXA2

SNPs/Variantsfor ANXA2

Disorders & Mutationsfor ANXA2

Medical Newsfor ANXA2

Publicationsfor ANXA2

Search for ANXA2

Genome Databases showing ANXA2

Other Databases showing ANXA2

Specialized Databases showing ANXA2

Licensable Technologiesfor ANXA2

Servicesfor ANXA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ANXA2

Summaries
for ANXA2

Genomic Location
for ANXA2

Proteins
for ANXA2

Protein Domains/
Families
for ANXA2

Gene Function
for ANXA2

Pathways & Interactions
for ANXA2

Drugs & Compounds
for ANXA2

Transcripts
for ANXA2

Expression
for ANXA2

Orthologs
for ANXA2

Paralogs
for ANXA2

SNPs/Variants
for ANXA2

Disorders & Mutations
for ANXA2

Medical News
for ANXA2

Publications
for ANXA2

Licensable Technologies
for ANXA2

Services
for ANXA2