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ANXA2 Gene

protein-coding   GIFtS: 70
GCID: GC15M060639

Annexin A2


(Previous symbols: ANX2, ANX2L4, CAL1H, LPC2D)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Annexin A21 2     LIP22 5
ANX2L41 2 3 5     HEL-S-2702
LPC2D1 2 3 5     LPC22
ANX21 2 3     P362
CAL1H1 2 3     annexin-22
Annexin II1 2 3     Calpactin I Heavy Polypeptide2
Calpactin I Heavy Chain2 3     Chromobindin 82
Calpactin-1 Heavy Chain2 3     chromobindin-82
Lipocortin II2 3     Epididymis Secretory Protein Li 2702
Placental Anticoagulant Protein IV2 3     Annexin-23
Protein I2 3     Chromobindin-83
PAP-IV2 3     p363

External Ids:    HGNC: 5371   Entrez Gene: 3022   Ensembl: ENSG000001827187   OMIM: 1517405   UniProtKB: P073553   

Export aliases for ANXA2 gene to outside databases

Previous GC identifers: GC15M056197 GC15M053687 GC15M058218 GC15M058355 GC15M058426 GC15M037461


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANXA2 Gene:
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein
family play a role in the regulation of cellular growth and in signal transduction pathways. This protein
functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three
pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ANXA2 Gene:
ANXA2 (annexin A2) is a protein-coding gene. GO annotations related to this gene include cytoskeletal protein binding and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANXA2_HUMAN, P07355
Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic
phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response

Gene Wiki entry for ANXA2 (Annexin A2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANXA2 gene promoter:
         AP-2alpha isoform 3   AP-1   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANXA2 promoter sequence
   Search Chromatin IP Primers for ANXA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANXA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.2   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q22.2

ANXA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M060639:  view genomic region     (about GC identifiers)

Start:
60,639,333 bp from pter      End:
60,695,082 bp from pter
Size:
55,750 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANXA2_HUMAN, P07355 (See protein sequence)
Recommended Name: Annexin A2  
Size: 339 amino acids; 38604 Da
Subunit: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with
ATP1B1 and DYSF (By similarity). Interacts with human cytomegalovirus (HCMV). Interacts with COCH
Miscellaneous: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved
with exocytosis
Sequence caution: Sequence=AAH66955.2; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for ANXA2 (see all 7):
1W7B (3D)        1XJL (3D)        2HYU (3D)        2HYV (3D)        2HYW (3D)        4DRW (3D)    
Secondary accessions: Q567R4 Q6N0B3 Q8TBV2 Q96DD5 Q9UDH8
Alternative splicing: 2 isoforms:  P07355-1   P07355-2   

Explore the universe of human proteins at neXtProt for ANXA2: NX_P07355

Explore proteomics data for ANXA2 at MOPED

Post-translational modifications: 

  • Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface1
  • ISGylated1
  • Ubiquitination2 at Lys49, Lys104, Lys157, Lys227, Lys313, Lys324
  • Modification sites at PhosphoSitePlus

  • See ANXA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001002857.1  NP_001002858.1  NP_001129487.1  NP_004030.1  

    ENSEMBL proteins: 
     ENSP00000379342   ENSP00000387545   ENSP00000346032   ENSP00000453754   ENSP00000411352  
     ENSP00000453464   ENSP00000453039   ENSP00000453841   ENSP00000453859   ENSP00000454096  
     ENSP00000452876   ENSP00000453556   ENSP00000453356   ENSP00000453925   ENSP00000453579  
     ENSP00000452921   ENSP00000453869   ENSP00000452895   ENSP00000453174   ENSP00000453663  
     ENSP00000452981   ENSP00000453739   ENSP00000453000   ENSP00000453694   ENSP00000453770  
     ENSP00000452858   ENSP00000452958   ENSP00000453566   ENSP00000453945   ENSP00000453742  

    ANXA2 Human Recombinant Protein Products:

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    Novus Biologicals ANXA2 Proteins
    Novus Biologicals ANXA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ANXA2
    Cloud-Clone Corp. Proteins for ANXA2

     
    Search eBioscience for Proteins for ANXA2 

     
    antibodies-online proteins for ANXA2 (31 products) 

     
    antibodies-online peptides for ANXA2

    ANXA2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANXA2
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    antibodies-online antibodies for ANXA2 (115 products) 

    ANXA2 Assay Products:

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    antibodies-online kits for ANXA2 (39 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANXA: Annexins

    4 InterPro protein domains:
     IPR002389 AnnexinII
     IPR018502 Annexin_repeat
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS

    Graphical View of Domain Structure for InterPro Entry P07355

    ProtoNet protein and cluster: P07355

    2 Blocks protein domains:
    IPB001464 Annexin
    IPB002389 Annexin type II signature


    UniProtKB/Swiss-Prot: ANXA2_HUMAN, P07355
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    Find genes that share domains with ANXA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANXA2_HUMAN, P07355
    Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic
    phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response

         Genatlas biochemistry entry for ANXA2:
    annexin A2,calcium and phospholipid binding protein,calpactin 1,involved in exocytosis,overexpressed in small cell
    lung carcinoma

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity ----
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI19724273
    GO:0005544calcium-dependent phospholipid binding IDA2138016
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding IMP--
         
    Find genes that share ontologies with ANXA2           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Anxa2):
     cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism 

    Find genes that share phenotypes with ANXA2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Anxa2tm1Kah for ANXA2

       genOway: Develop your customized and physiologically relevant rodent model for ANXA2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANXA2:
    hsa-mir-769-3p (MIRT039126), hsa-mir-155-5p (MIRT020897), hsa-mir-1 (MIRT001388), hsa-mir-132-3p (MIRT045844)

    Block miRNA regulation of human, mouse, rat ANXA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANXA2 (see all 13):
    hsa-miR-3673 hsa-miR-206 hsa-miR-1206 hsa-miR-130a* hsa-miR-548k hsa-miR-23c hsa-miR-1 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidANXA2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANXA2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): ANXA2 (NM_001002858)
    Sino Biological Human cDNA Clone for ANXA2
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANXA2_HUMAN, P07355: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In
    the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to
    stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytosol3
    cytoskeleton2
    endosome2
    nucleus2
    endoplasmic reticulum1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA--
    GO:0005737cytoplasm ----
    GO:0005769early endosome IEA--

    Find genes that share ontologies with ANXA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANXA2 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of CFTR activity norm and CF
    Regulation of CFTR activity norm and CF 0.38
    2Tyrosine Kinases / Adaptors
    Tyrosine Kinases / Adaptors
    3Prostaglandin Synthesis and Regulation
    Prostaglandin Synthesis and Regulation
    4Ca, cAMP and Lipid Signaling
    Ca, cAMP and Lipid Signaling


    Find genes that share SuperPaths with ANXA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for ANXA2
        Ca, cAMP and Lipid Signaling
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for ANXA2
        Regulation of CFTR activity (norm and CF)

    1 BioSystems Pathway for ANXA2
        Prostaglandin Synthesis and Regulation



        Pathway & Disease-focused RT2 Profiler PCR Array including ANXA2: 
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANXA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANXA2 (P073551, 2, 3 ENSP000003460324) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K4Q9Y6R42, 3, ENSP000003759864MINT-51382 I2D: score=3 STRING: ENSP00000375986
    PCNAP120042, 3, ENSP000003684384MINT-7995252 I2D: score=2 STRING: ENSP00000368438
    MLH1P406921, 3EBI-352622,EBI-744248 I2D: score=1 
    YWHAZP631042, 3, ENSP000003095034MINT-3297866 I2D: score=1 STRING: ENSP00000309503
    CD99P142093, ENSP000003705884I2D: score=3 STRING: ENSP00000370588
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEP11866539
    GO:0001765membrane raft assembly IMP--
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0006900membrane budding IMP--
    GO:0007589body fluid secretion IEA--

    Find genes that share ontologies with ANXA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANXA2

    1 HMDB Compound for ANXA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for ANXA2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tenecteplaset- PA (see all 4)191588-94-0target--15194650 10578524 12730231

    Selected Novoseek inferred chemical compound relationships for ANXA2 gene (see all 62)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phospholipid 57.7 35 12730231 (3), 8490575 (2), 9451817 (1), 14668336 (1) (see all 25)
    calcium 45.7 95 7947730 (5), 11074597 (4), 9044052 (4), 16882661 (3) (see all 44)
    epsilon aminocaproic acid 41.6 2 12453439 (1)
    phosphatidylserine 40.8 12 10956650 (2), 15545357 (2), 2138016 (1), 8200445 (1) (see all 5)
    tyrosine 39.8 33 18565825 (4), 16527271 (3), 9013554 (2), 19020748 (2) (see all 21)
    pro-gastrin 39.2 3 17671195 (1)
    castanospermine 31.8 2 7499436 (1)
    glyceraldehyde 3-phosphate 30 8 7584597 (2), 1999197 (2), 17268060 (1), 19407367 (1) (see all 6)
    retinoic acid 26.1 18 12165291 (6), 19642359 (2), 10099141 (2), 17278423 (2) (see all 8)
    lysine 24.8 4 11866428 (2), 7549065 (1), 16373665 (1)



    Find genes that share compounds with ANXA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANXA2 gene (4 alternative transcripts): 
    NM_001002857.1  NM_001002858.2  NM_001136015.2  NM_004039.2  

    Unigene Cluster for ANXA2:

    Annexin A2
    Hs.511605  [show with all ESTs]
    Unigene Representative Sequence: AK309356
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 38):
    ENST00000396024(uc002agk.3 uc002agn.3 uc002agl.3 uc002agm.3 uc010uhd.2)
    ENST00000451270 ENST00000332680 ENST00000504475 ENST00000560014 ENST00000421017
    ENST00000559647 ENST00000559176 ENST00000558985 ENST00000560466 ENST00000559818
    ENST00000558132 ENST00000561022 ENST00000560367 ENST00000558503 ENST00000558998
    ENST00000559559(uc010bgj.3) ENST00000560389
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ANXA2 (see all 13):
    hsa-miR-3673 hsa-miR-206 hsa-miR-1206 hsa-miR-130a* hsa-miR-548k hsa-miR-23c hsa-miR-1 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidANXA2 3' UTR sequence
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat ANXA2

    Additional mRNA sequence: 

    AK222542.1 AK297923.1 AK309356.1 BC001388.2 BC001748.1 BC009564.1 BC013843.1 BC015834.1 
    BC016774.1 BC021114.1 BC023990.1 BC052558.1 BC052567.1 BC066955.1 BC068065.1 BC093056.1 
    BT007432.1 BX640598.1 D00017.1 D28364.1 

    Selected DOTS entries (see all 102):

    DT.91648997  DT.100892145  DT.91783683  DT.100892182  DT.95163829  DT.75199496  DT.100892123  DT.100892113 
    DT.91783755  DT.91783708  DT.95102229  DT.101987435  DT.95209548  DT.100808780  DT.95325315  DT.91783750 
    DT.91868264  DT.91783724  DT.95163951  DT.100892175  DT.91783792  DT.121072008  DT.100892108  DT.121072016 

    Selected AceView cDNA sequences (see all 113):

    AA622852 BF221946 AA595953 BM991327 BM854211 AL697927 BE905065 F31768 
    AW002699 AA527148 BM766947 BE906789 BM851995 AA535261 BF149210 T11151 
    AA102522 AI126686 AA377286 AI277242 H41145 AA377302 F36749 F24513 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANXA2 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                          -     -     -     -     -           -                 -                                                   
    SP2:              -     -     -     -     -                       -                 -                                                   
    SP3:                          -     -     -     -     -           -                                                                     
    SP4:              -           -     -     -     -     -           -                                                                     
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for ANXA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANXA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCCAGCTA
    ANXA2 Expression
    About this image


    ANXA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Heart (Cardiovascular System)
             Heart Tube
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
    ANXA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANXA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.511605
        Pathway & Disease-focused RT2 Profiler PCR Array including ANXA2: 
              Hypoxia Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANXA2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anxa21 , 5 annexin A21, 5 89.58(n)1
    97.64(a)1
      9 (38.58 cM)5
    123061  NM_007585.31  NP_031611.11 
     694536205 
    chicken
    (Gallus gallus)
    Aves ANXA21 annexin A2 81.22(n)
    89.68(a)
      396297  NM_205351.1  NP_990682.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA26
    annexin A2
    75(a)
    1 ↔ 1
    GL343428.1(490966-509914)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3977542 annexin II 77.07(n)    M60768.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anxa2a2 annexin A2a 76.36(n)   325557  AY178796.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nex-33 Annexin 36(a)   III(4513890-4515916)   --


    ENSEMBL Gene Tree for ANXA2 (if available)
    TreeFam Gene Tree for ANXA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANXA2 gene
    ANXA32  ANXA62  ANXA52  ANXA12  ANXA92  ANXA72  ANXA82  ANXA112  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA2 using alignment to 23 protein entries:     ANXA2_HUMAN (see all proteins):
    ANXA2P2    ANXA1    ANXA8L2    ANXA13    ANXA8    ANXA8L1
    DKFZp686H02120    ANXA3    ANXA4    ANXA6    ANXA5    ANXA11
    ANXA9    ANXA7    ANXA10

    Find genes that share paralogs with ANXA2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ANXA2
    PGOHUM00000238817 PGOHUM00000245733


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANXA2 (see all 1266)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs584430811,2
    --60638877(+) TGTATC/GAGCGA 4 -- ds50010--------
    rs791187181,2
    C--60639002(+) TTCTCA/GATCCT 4 -- ds50010--------
    rs1433196641,2
    --60639044(+) CCCATC/TGGCTT 4 -- ds50010--------
    rs1150367121,2
    --60639084(+) AGCCTA/GCCCCA 4 -- ds50010--------
    rs762737151,2
    --60639116(+) AGTTTC/GTGGCT 4 -- ds50010--------
    rs607169621,2
    --60639119(+) TTGTGA/GCTGCC 4 -- ds50010--------
    rs1930635721,2
    --60639122(+) TGGCTA/GCCCCT 4 -- ds50010--------
    rs1407744571,2
    C--60639127(+) GCCCC-/TGATGC 4 -- ds50010--------
    rs358286991,2
    C,F--60639256(+) TCTATC/TGAAAT 4 -- ds50016Minor allele frequency- T:0.28NA EA 248
    rs1155654481,2
    C,F--60639275(+) CCTGCG/ACTGTC 4 -- ds50011Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for ANXA2 (60639333 - 60695082 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ANXA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656603CNV Deletion23128226
    esv273112CNV Insertion20981092
    esv1613497CNV Insertion17803354
    esv2592269CNV Insertion19546169
    esv271908CNV Insertion20981092
    esv1071950CNV Insertion17803354
    dgv2392n71CNV Loss21882294
    nsv7266OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ANXA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151740    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for ANXA2:
    Cancer     Antiphospholipid syndrome

    Find genes that share disorders with ANXA2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ANXA2 gene (see all 58)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    antiphospholipid syndrome 53.3 2 12627665 (1), 18827060 (1)
    leukemia promyelocytic acute 51.3 9 11815288 (1), 19781379 (1), 11108960 (1), 15070701 (1) (see all 8)
    pancreatic cancer 31.9 17 18712570 (6), 15194650 (3), 8269629 (3), 17456763 (3) (see all 6)
    disseminated intravascular coagulation 27.8 2 18024623 (1), 16757074 (1)
    carcinoma squamous cell 27 11 12921564 (2), 19339807 (1), 18822406 (1), 17663946 (1) (see all 9)
    tumors 26.4 96 18608216 (4), 19452941 (4), 18924133 (3), 7787249 (3) (see all 43)
    metastasis 25.3 17 18608216 (2), 16643892 (2), 18220793 (2), 18636554 (2) (see all 12)
    cancer 23.2 30 18712570 (2), 9482108 (1), 14522961 (1), 16408090 (1) (see all 25)
    coagulopathy 15.5 5 19285282 (1), 12513745 (1), 15567461 (1), 16757074 (1)
    nonmetastatic 15.3 5 18924133 (1), 16643892 (1), 17205601 (1)

    Genetic Association Database (GAD): ANXA2
    Human Genome Epidemiology (HuGE) Navigator: ANXA2 (6 documents)

    Export disorders for ANXA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANXA2 gene, integrated from 10 sources (see all 652):
    (articles sorted by number of sources associating them with ANXA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phospholipid-associated annexin A2-S100A10 heterotetramer and its subunits: characterization of the interaction with tissue plasminogen activator, plasminogen, and plasmin. (PubMed id 12730231)1, 7, 9 MacLeod T.J....Waisman D.M. (J. Biol. Chem. 2003)
    2. The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha. (PubMed id 1825830)1, 2, 9 Jindal H.K.... Vishwanatha J.K. (J. Biol. Chem. 1991)
    3. The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein. (PubMed id 8636985)1, 2, 9 Burger A.... Weber K. (J. Mol. Biol. 1996)
    4. An endothelial cell-surface form of annexin II binds human cytomegalovirus. (PubMed id 8117306)1, 2, 9 Wright J.F.... Wasi S. (Biochem. Biophys. Res. Commun. 1994)
    5. Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility. (PubMed id 21886777)1, 2 Goel M.... Bhattacharya S.K. (PLoS ONE 2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. [A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer]. (PubMed id 20540360)1, 4 Lisitskaia K.V....Shishkin S.S. (Mol. Gen. Mikrobiol. Virusol. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    10. Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. (PubMed id 15784727)1, 4 Baldwin C....Steinberg M.H. (Blood 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 302 HGNC: 537 AceView: ANXA2.1 Ensembl:ENSG00000182718 euGenes: HUgn302
    ECgene: ANXA2 H-InvDB: ANXA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ANXA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANXA2 Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/086

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANXA2 gene:
    Search GeneIP for patents involving ANXA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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