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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANXA2 Gene

protein-coding   GIFtS: 68
GCID: GC15M060639

annexin A2


(Previous symbols: ANX2, ANX2L4, CAL1H, LPC2D)
 Explore 91 diseases affiliated with
ANXA2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ANXA2    

Aliases
for ANXA2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Annexin A21 2     Protein I2 3
ANX2L41 2 3 5     PAP-IV2 3
LPC2D1 2 3 5     LPC22
ANX21 2 3     P362
CAL1H1 2 3     Annexin-23
LIP21 2 5     Calpactin I Heavy Polypeptide2
Annexin II2 3     Chromobindin 82
Calpactin I Heavy Chain2 3     Chromobindin-83
Calpactin-1 Heavy Chain2 3     Annexin-23
Lipocortin II2 3     Chromobindin-83
Placental Anticoagulant Protein IV2 3     P362

External Ids:    HGNC: 5371   Entrez Gene: 3022   Ensembl: ENSG000001827187   OMIM: 1517405   UniProtKB: P073553   

Export aliases for ANXA2 gene to outside databases

Previous GC identifers: GC15M056197 GC15M053687 GC15M058218 GC15M058355 GC15M058426 GC15M037461


Summaries
for ANXA2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ANXA2:
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family
play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an
autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on
chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ANXA2_HUMAN, P07355
Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic
phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response

Gene Wiki entry for ANXA2 (Annexin A2)


Genomic Views
for ANXA2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANXA2 gene promoter:
         AP-2alpha isoform 3   AP-1   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANXA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANXA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.2   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q22.2

ANXA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M060639:  view genomic region     (about GC identifiers)

Start:
 60,639,333 bp from pter      End:
 60,695,082 bp from pter
Size:
 55,750 bases      Orientation:
 minus strand

Proteins
for ANXA2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANXA2_HUMAN, P07355 (See protein sequence)
Recommended Name: Annexin A2  
Size: 339 amino acids; 38604 Da
Subunit: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1
and DYSF (By similarity). Interacts with human cytomegalovirus (HCMV). Interacts with COCH
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the
lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism
Miscellaneous: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with
exocytosis
Sequence caution: Sequence=AAH66955.2; Type=Erroneous initiation;
6 PDB 3D structures from and Proteopedia for ANXA2:
1W7B (3D)        1XJL (3D)        2HYU (3D)        2HYV (3D)        2HYW (3D)        4DRW (3D)    
Secondary accessions: Q567R4 Q6N0B3 Q8TBV2 Q96DD5 Q9UDH8
Alternative splicing: 2 isoforms:  P07355-1   P07355-2   

Explore the universe of human proteins at neXtProt for ANXA2: NX_P07355

Post-translational modifications:

  • Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface1
  • ISGylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P07355

    • ANXA2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001002857.1  NP_001002858.1  NP_001129487.1  NP_004030.1  

    ENSEMBL proteins: 
     ENSP00000379342   ENSP00000387545   ENSP00000346032   ENSP00000453754   ENSP00000411352  
     ENSP00000453464   ENSP00000453039   ENSP00000453841   ENSP00000453859   ENSP00000454096  
     ENSP00000452876   ENSP00000453556   ENSP00000453356   ENSP00000453925   ENSP00000453579  
     ENSP00000452921   ENSP00000453869   ENSP00000452895   ENSP00000453174   ENSP00000453663  
     ENSP00000452981   ENSP00000453739   ENSP00000453000   ENSP00000453694   ENSP00000453770  
     ENSP00000452858   ENSP00000452958   ENSP00000453566   ENSP00000453945   ENSP00000453742  

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    Uscn Proteins for ANXA2

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane IEA--
    GO:0005625soluble fraction ----
    GO:0005737cytoplasm ----
    GO:0005769early endosome IEA--
    GO:0005811lipid particle IDA14741744


    ANXA2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ANXA2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ANXA2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002389 AnnexinII
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR018502 Annexin_repeat

    Graphical View of Domain Structure for InterPro Entry P07355

    ProtoNet protein and cluster: P07355

    2 Blocks protein families:
    IPB001464 Annexin
    IPB002389 Annexin type II signature


    UniProtKB/Swiss-Prot: ANXA2_HUMAN, P07355
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    Function
    for ANXA2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ANXA2_HUMAN, P07355
    Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic
    phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response

         Genatlas biochemistry entry for ANXA2:
    annexin A2,calcium and phospholipid binding protein,calpactin 1,involved in exocytosis,overexpressed in small cell lung
    carcinoma

    miRNA
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    hsa-mir-1 (MIRT001388)

    OriGene 3'-UTR Clone (see all 4): ANXA2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANXA2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate ANXA2 (see all 13):
    hsa-miR-3673 hsa-miR-206 hsa-miR-1206 hsa-miR-130a* hsa-miR-548k hsa-miR-23c hsa-miR-1 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmid: ANXA2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
    GO:0005544calcium-dependent phospholipid binding IDA2138016
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding IEA--


    ANXA2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Anxa2tm1Kah for ANXA2
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Anxa2):
     cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism 

    ANXA2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ANXA2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Tyrosine Kinases / Adaptors
    		Tyrosine Kinases / Adaptors1.00
    2Prostaglandin Synthesis and Regulation
    		Prostaglandin Synthesis and Regulation1.00
    3Ca, cAMP and Lipid Signaling
    		Ca, cAMP and Lipid Signaling1.00
    4wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    		Regulation of CFTR activity (norm and CF)0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for ANXA2
        Ca, cAMP and Lipid Signaling
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for ANXA2
        Regulation of CFTR activity (norm and CF)

    1 BioSystems Pathway for ANXA2 
        Prostaglandin Synthesis and Regulation



    ANXA2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANXA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/95 Interacting proteins for ANXA2 (P073551, 2, 3 ENSP000003460324) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K4Q9Y6R42, 3, ENSP000003759864MINT-51382 I2D: score=3 STRING: ENSP00000375986
    PCNAP120042, 3, ENSP000003684384MINT-7995252 I2D: score=2 STRING: ENSP00000368438
    MLH1P406921, 3EBI-2211824,EBI-744248 I2D: score=1 
    YWHAZP631042, 3, ENSP000003095034MINT-3297866 I2D: score=1 STRING: ENSP00000309503
    CD99P142093, ENSP000003705884I2D: score=3 STRING: ENSP00000370588
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS7961821
    GO:0001525angiogenesis IEP11866539
    GO:0007589body fluid secretion IEA--
    GO:0030199collagen fibril organization IEA--
    GO:0031340positive regulation of vesicle fusion IDA2138016


    ANXA2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ANXA2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANXA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ANXA2

    1 HMDB Compound for ANXA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for ANXA2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tenecteplaset- PA (see all 4)191588-94-0target--15194650 10578524 12730231

    10/62 Novoseek chemical compound relationships for ANXA2 gene (see all 62)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phospholipid 57.7 35 12730231 (3), 8490575 (2), 9451817 (1), 14668336 (1) (see all 25)
    calcium 45.7 95 7947730 (5), 11074597 (4), 9044052 (4), 16882661 (3) (see all 44)
    epsilon aminocaproic acid 41.6 2 12453439 (1)
    phosphatidylserine 40.8 12 10956650 (2), 15545357 (2), 2138016 (1), 8200445 (1) (see all 5)
    tyrosine 39.8 33 18565825 (4), 16527271 (3), 9013554 (2), 19020748 (2) (see all 21)
    pro-gastrin 39.2 3 17671195 (1)
    castanospermine 31.8 2 7499436 (1)
    glyceraldehyde 3-phosphate 30 8 7584597 (2), 1999197 (2), 17268060 (1), 19407367 (1) (see all 6)
    retinoic acid 26.1 18 12165291 (6), 19642359 (2), 10099141 (2), 17278423 (2) (see all 8)
    lysine 24.8 4 11866428 (2), 7549065 (1), 16373665 (1)

    Search CenterWatch for drugs/clinical trials and news about ANXA2 

    Transcripts
    for ANXA2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ANXA2 gene (4 alternative transcripts): 
    NM_001002857.1  NM_001002858.2  NM_001136015.2  NM_004039.2  

    Unigene Cluster for ANXA2:

    Annexin A2
    Hs.511605  [show with all ESTs]
    Unigene Representative Sequence: AK309356
    18/38 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 38):
    ENST00000396024(uc002agk.3 uc002agn.3 uc002agl.3 uc002agm.3 uc010uhd.2)
    ENST00000451270 ENST00000332680 ENST00000504475 ENST00000560014 ENST00000421017
    ENST00000559647 ENST00000559176 ENST00000558985 ENST00000560466 ENST00000559818
    ENST00000558132 ENST00000561022 ENST00000560367 ENST00000558503 ENST00000558998
    ENST00000559559(uc010bgj.3) ENST00000560389

    miRNA
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    hsa-miR-3673 hsa-miR-206 hsa-miR-1206 hsa-miR-130a* hsa-miR-548k hsa-miR-23c hsa-miR-1 hsa-miR-548l
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK222542.1 AK297923.1 AK309356.1 BC001388.2 BC001748.1 BC009564.1 BC013843.1 BC015834.1 
    BC016774.1 BC021114.1 BC023990.1 BC052558.1 BC052567.1 BC066955.1 BC068065.1 BC093056.1 
    BT007432.1 BX640598.1 D00017.1 D28364.1 

    24/102 DOTS entries (see all 102):

    DT.91648997  DT.100892145  DT.91783683  DT.100892182  DT.95163829  DT.75199496  DT.100892123  DT.100892113 
    DT.91783755  DT.91783708  DT.95102229  DT.101987435  DT.95209548  DT.95325315  DT.100808780  DT.91783750 
    DT.91868264  DT.91783724  DT.95163951  DT.100892175  DT.91783792  DT.121072008  DT.100892108  DT.121072016 

    24/113 AceView cDNA sequences (see all 113):

    AA622852 BF221946 AA595953 BM991327 BM854211 AL697927 AA527148 BE905065 
    BM766947 AW002699 BM851995 F31768 BE906789 AA535261 T11151 AA102522 
    AA377286 BF149210 AI277242 AI126686 AA377302 F24513 H41145 F36749 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ANXA2 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                          -     -     -     -     -           -                 -                                                   
    SP2:              -     -     -     -     -                       -                 -                                                   
    SP3:                          -     -     -     -     -           -                                                                     
    SP4:              -           -     -     -     -     -           -                                                                     
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for ANXA2

    Expression
    for ANXA2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANXA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTCCAGCTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ANXA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANXA2

    SOURCE GeneReport for Unigene cluster: Hs.511605
        SABiosciences Expression via Pathway-Focused PCR Array including ANXA2: 
              Hypoxia Signaling Pathway in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for ANXA2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANXA2 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ANXA21 annexin A2 81.22(n)
    89.68(a)    		   396297  NM_205351.1  NP_990682.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ANXA26
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343428.1(491633-503974)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3977542 annexin II 77.07(n)    M60768.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii anxa2a2 annexin A2a 76.36(n)   325557  AY178796.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG334986
    CG334916
    (see all 7)    		 --
    		 41(a)
    41(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 X(20096211-20097053)
    X(20072788-20073634)
    worm
    (Caenorhabditis elegans)    		 Secernentea nex-33 Annexin 36(a)   III(4513890-4515916)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ANNAT56
    ANNAT16
    (see all 8)    		 annexin D1
    (see all 8)    		 36(a)
    30(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 1(25519442-25520774)
    1(13225197-13227195)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 9)    		 annexin, putative, expressed
    (see all 9)    		 38(a)
    32(a)
    (see all 9)    		 many ↔ many
    many ↔ many
    (see all 9)    		 9(13705487-13710510)
    8(20456985-20458908)


    ENSEMBL Gene Tree for ANXA2 (if available)
    TreeFam Gene Tree for ANXA2 (if available) 

    Paralogs
    for ANXA2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANXA2 gene
    ANXA32  ANXA62  ANXA12  ANXA52  ANXA92  ANXA72  ANXA82  ANXA112  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA2 using alignment to 23 protein entries:     ANXA2_HUMAN (see all proteins):
    ANXA2P2    ANXA1    ANXA8L2    ANXA13    ANXA8    ANXA8L1
    DKFZp686H02120    ANXA3    ANXA4    ANXA6    ANXA5    ANXA11
    ANXA9    ANXA7    ANXA10

    ANXA2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ANXA2
    PGOHUM00000238817 PGOHUM00000245733


    Genomic Variants
    for ANXA2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1046 NCBI SNPs in ANXA2 are shown (see all 1046)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs584430811,2
    		--60638877(+) TGTATC/GAGCGA 4 -- ds50010--------
    rs791187181,2
    		--60639002(+) TTCTCA/GATCCT 4 -- ds50010--------
    rs1433196641,2
    		--60639044(+) CCCATC/TGGCTT 4 -- ds50010--------
    rs1150367121,2
    		--60639084(+) AGCCTA/GCCCCA 4 -- ds50010--------
    rs762737151,2
    		--60639116(+) AGTTTC/GTGGCT 4 -- ds50010--------
    rs607169621,2
    		--60639119(+) TTGTGA/GCTGCC 4 -- ds50010--------
    rs1930635721,2
    		--60639122(+) TGGCTA/GCCCCT 4 -- ds50010--------
    rs1407744571,2
    		C,--60639127(+) GCCCC-/TGATGC 4 -- ds50010--------
    rs358286991,2
    		C,F,--60639256(+) TCTATC/TGAAAT 4 -- ds50016Minor allele frequency- T:0.28NA EA 248
    rs1155654481,2
    		F,--60639275(+) CCTGCG/ACTGTC 4 -- ds50011Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for ANXA2 (60639333 - 60695082 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 14 variations for ANXA2
         14 CNVs: 102114 87695 87700 76974 76979 87698 87699 76978 76975 87697 76977 87696 87701 76973

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    Disorders / Diseases
    for ANXA2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ANXA2 for disorders           About GeneDecksing

    OMIM gene information: 151740    OMIM disorders: --

    20/91 diseases for ANXA2 (see all 91):    About MalaCards
    disseminated intravascular coagulation    middle ear cholesteatoma    abdominal aortic aneurysm    severe acute respiratory syndrome
    juvenile myelomonocytic leukemia    aortic aneurysm    anaplastic astrocytoma    squamous cell carcinoma
    myelomonocytic leukemia    amyotrophic lateral sclerosis    lupus erythematosus    antiphospholipid syndrome
    b-cell lymphomas    oral squamous cell carcinoma    lateral sclerosis    esophageal squamous cell carcinoma
    systemic lupus erythematosus    cystic fibrosis    acute promyelocytic leukemia    pancreatic ductal adenocarcinoma

    2 diseases from the University of Copenhagen DISEASES database for ANXA2:
    Cancer     Antiphospholipid syndrome

    10/58 Novoseek disease relationships for ANXA2 gene (see all 58)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    antiphospholipid syndrome 53.3 2 12627665 (1), 18827060 (1)
    leukemia promyelocytic acute 51.3 9 11815288 (1), 19781379 (1), 11108960 (1), 15070701 (1) (see all 8)
    pancreatic cancer 31.9 17 18712570 (6), 15194650 (3), 8269629 (3), 17456763 (3) (see all 6)
    disseminated intravascular coagulation 27.8 2 18024623 (1), 16757074 (1)
    carcinoma squamous cell 27 11 12921564 (2), 19339807 (1), 18822406 (1), 17663946 (1) (see all 9)
    tumors 26.4 96 18608216 (4), 19452941 (4), 18924133 (3), 7787249 (3) (see all 43)
    metastasis 25.3 17 18608216 (2), 16643892 (2), 18220793 (2), 18636554 (2) (see all 12)
    cancer 23.2 30 18712570 (2), 9482108 (1), 14522961 (1), 16408090 (1) (see all 25)
    coagulopathy 15.5 5 19285282 (1), 12513745 (1), 15567461 (1), 16757074 (1)
    nonmetastatic 15.3 5 18924133 (1), 16643892 (1), 17205601 (1)

    Genetic Association Database (GAD): ANXA2
    Human Genome Epidemiology (HuGE) Navigator: ANXA2 (6 documents)

    Export disorders for ANXA2 gene to outside databases

    Publications
    for ANXA2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANXA2 gene, integrated from 9 sources (see all 602):
    (articles sorted by number of sources associating them with ANXA2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Phospholipid-associated annexin A2-S100A10 heterotetramer and its subunits: characterization of the interaction with tissue plasminogen activator, plasminogen, and plasmin. (PubMed id 12730231)1, 7, 9 MacLeod T.J....Waisman D.M. (2003)
    2. The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha. (PubMed id 1825830)1, 2, 9 Jindal H.K.... Vishwanatha J.K. (1991)
    3. The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein. (PubMed id 8636985)1, 2, 9 Burger A.... Weber K. (1996)
    4. An endothelial cell-surface form of annexin II binds human cytomegalovirus. (PubMed id 8117306)1, 2, 9 Wright J.F.... Wasi S. (1994)
    5. Cochlin induced TREK-1 co-expression and annexin A2 s ecretion: role in trabecular meshwork cell elongation and motility. (PubMed id 21886777)1, 2 Goel M....Bhattacharya S.K. (2011)
    6. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    7. Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. (PubMed id 15784727)1, 4 Baldwin C....Steinberg M.H. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface. (PubMed id 15302870)1, 2 Deora A.B.... Hajjar K.A. (2004)
    10. Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption. (PubMed id 7961821)1, 3 Takahashi S....Roodman G.D. (1994)

    External Searches for ANXA2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ANXA2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 302 HGNC: 537 AceView: ANXA2.1 Ensembl:ENSG00000182718 euGenes: HUgn302
    ECgene: ANXA2 H-InvDB: ANXA2

    Other Databases showing ANXA2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ANXA2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANXA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANXA2 Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt086.shtml

    Intellectual Property
    for ANXA2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ANXA2 gene:
    Search GeneIP for patents involving ANXA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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