Aliases for ANXA2 Gene
External Ids for ANXA2 Gene
Previous HGNC Symbols for ANXA2 Gene
Previous GeneCards Identifiers for ANXA2 Gene
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ANXA2 Gene
ANXA2 (Annexin A2) is a Protein Coding gene. Diseases associated with ANXA2 include keloid formation and pancreatic cancer. Among its related pathways are Platelet activation, signaling and aggregation and Cardiac conduction. GO annotations related to this gene include poly(A) RNA binding and Rab GTPase binding. An important paralog of this gene is ANXA4.
UniProtKB/Swiss-Prot for ANXA2 Gene
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).