Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANXA13 Gene

Aliases for ANXA13 Gene

  • Annexin A13 2 3
  • ANX13 3 4 6
  • ISA 3 4 6
  • Intestine-Specific Annexin 3 4
  • Annexin XIII 3 4
  • Annexin-13 3 4
  • Annexin, Intestine-Specific 3

External Ids for ANXA13 Gene

Previous Symbols for ANXA13 Gene

  • ANX13

Summaries for ANXA13 Gene

Entrez Gene Summary for ANXA13 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA13 Gene

ANXA13 (Annexin A13) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA9.

Gene Wiki entry for ANXA13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA13 Gene

Genomics for ANXA13 Gene

Genomic Location for ANXA13 Gene

Start:
123,680,794 bp from pter
End:
123,737,407 bp from pter
Size:
56,614 bases
Orientation:
Minus strand

Genomic View for ANXA13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANXA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA13 Gene

Regulatory Elements for ANXA13 Gene

Proteins for ANXA13 Gene

  • Protein details for ANXA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27216-ANX13_HUMAN
    Recommended name:
    Annexin A13
    Protein Accession:
    P27216
    Secondary Accessions:
    • Q9BQR5

    Protein attributes for ANXA13 Gene

    Size:
    316 amino acids
    Molecular mass:
    35415 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANXA13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANXA13 Gene

Proteomics data for ANXA13 Gene at MOPED

Post-translational modifications for ANXA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA13 Gene

No data available for DME Specific Peptides for ANXA13 Gene

Domains for ANXA13 Gene

Gene Families for ANXA13 Gene

HGNC:

Protein Domains for ANXA13 Gene

UniProtKB/Swiss-Prot:

ANX13_HUMAN
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid:
    • P27216
Family:
  • Belongs to the annexin family.:
    • P27216
Similarity:
  • Contains 4 annexin repeats.:
    • P27216
genes like me logo Genes that share domains with ANXA13: view

Function for ANXA13 Gene

Molecular function for ANXA13 Gene

GENATLAS Biochemistry: annexin A13,calcium and phospholipid binding protein

Gene Ontology (GO) - Molecular Function for ANXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 15813707
GO:0005509 calcium ion binding IEA --
GO:0005544 calcium-dependent phospholipid binding IEA --
GO:0031210 NOT phosphatidylcholine binding IDA 15813707
GO:1901611 phosphatidylglycerol binding IDA 15813707
genes like me logo Genes that share ontologies with ANXA13: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ANXA13 Gene

Localization for ANXA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA13 Gene

Cell membrane. Note=Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA13 Gene COMPARTMENTS Subcellular localization image for ANXA13 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ANXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane NAS 1530946
GO:0016323 basolateral plasma membrane ISS --
GO:0016324 apical plasma membrane ISS --
genes like me logo Genes that share ontologies with ANXA13: view

Pathways for ANXA13 Gene

SuperPathways for ANXA13 Gene

No Data Available

Interacting Proteins for ANXA13 Gene

Gene Ontology (GO) - Biological Process for ANXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation NAS 1530946
GO:0042997 negative regulation of Golgi to plasma membrane protein transport ISS --
GO:0042998 positive regulation of Golgi to plasma membrane protein transport ISS --
genes like me logo Genes that share ontologies with ANXA13: view

No data available for Pathways by source for ANXA13 Gene

Compounds for ANXA13 Gene

(1) HMDB Compounds for ANXA13 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with ANXA13: view

Transcripts for ANXA13 Gene

Unigene Clusters for ANXA13 Gene

Annexin A13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for ANXA13 Gene

GeneLoc Exon Structure for
ANXA13
ECgene alternative splicing isoforms for
ANXA13

Expression for ANXA13 Gene

mRNA expression in normal human tissues for ANXA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA13 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (20.6), Colon - Transverse (8.0), and Brain - Spinal cord (cervical c-1) (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA13 Gene

SOURCE GeneReport for Unigene cluster for ANXA13 Gene Hs.181107

mRNA Expression by UniProt/SwissProt for ANXA13 Gene

P27216-ANX13_HUMAN
Tissue specificity: Gut specific
genes like me logo Genes that share expressions with ANXA13: view

Orthologs for ANXA13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANXA13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANXA13 36
  • 99.44 (n)
  • 99.16 (a)
ANXA13 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANXA13 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA13 36
  • 89.54 (n)
  • 90.2 (a)
ANXA13 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa13 36
  • 85.28 (n)
  • 86.69 (a)
Anxa13 16
Anxa13 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANXA13 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANXA13 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa13 36
  • 84.15 (n)
  • 86.89 (a)
chicken
(Gallus gallus)
Aves ANXA13 36
  • 71.26 (n)
  • 72.13 (a)
ANXA13 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA13 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25115 36
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa13 36
  • 65.9 (n)
  • 67.66 (a)
zebrafish
(Danio rerio)
Actinopterygii anxa13 36
  • 58.03 (n)
  • 55.08 (a)
anxa13l 37
  • 54 (a)
OneToMany
Dr.16504 36
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 37
  • 48 (a)
OneToMany
AnnX 37
  • 41 (a)
OneToMany
Anxb11 37
  • 29 (a)
OneToMany
Anxb11 38
  • 46 (a)
AnnIX 38
  • 50 (a)
AnnX 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea nex-1 36
  • 49.06 (n)
  • 42.52 (a)
nex-4 37
  • 25 (a)
ManyToMany
nex-1 38
  • 40 (a)
nex-2 38
  • 46 (a)
rice
(Oryza sativa)
Liliopsida Os09g0394900 36
  • 48.26 (n)
  • 39.87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4592 37
  • 43 (a)
OneToOne
Species with no ortholog for ANXA13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA13 Gene

ENSEMBL:
Gene Tree for ANXA13 (if available)
TreeFam:
Gene Tree for ANXA13 (if available)

Paralogs for ANXA13 Gene

Paralogs for ANXA13 Gene

Selected SIMAP similar genes for ANXA13 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ANXA13: view

Variants for ANXA13 Gene

Sequence variations from dbSNP and Humsavar for ANXA13 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs725895 -- 123,699,935(-) AGGCA(C/G)TAATG intron-variant
rs970820 -- 123,726,209(+) GGCAT(A/T)TCAGC intron-variant
rs970821 -- 123,726,378(+) ATATG(C/T)TGTGC intron-variant
rs970822 -- 123,726,502(+) TAGCC(C/T)TTTTG intron-variant
rs971649 -- 123,720,035(+) AAACT(C/G)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA13 Gene

Variant ID Type Subtype PubMed ID
nsv831451 CNV Gain+Loss 17160897
nsv6373 CNV Loss 18451855

Relevant External Links for ANXA13 Gene

HapMap Linkage Disequilibrium report
ANXA13

Disorders for ANXA13 Gene

Relevant External Links for ANXA13

Genetic Association Database (GAD)
ANXA13
genes like me logo Genes that share disorders with ANXA13: view

No data available for UniProtKB/Swiss-Prot for ANXA13 Gene

Publications for ANXA13 Gene

  1. Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins. (PMID: 11961095) Iglesias J.M. … Fernandez M.-P. (Mol. Biol. Evol. 2002) 3 4 23
  2. A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin. (PMID: 1530946) Wice B.M. … Gordon J.I. (J. Cell Biol. 1992) 3 4 23
  3. Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins. (PMID: 9503022) Morgan R.O. … Fernandez M.P. (Genomics 1998) 2 3 23
  4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 49
  5. Structure-function relationship in annexin A13, the founder member of the vertebrate family of annexins. (PMID: 15813707) Turnay J. … Lizarbe M.A. (Biochem. J. 2005) 3 23

Products for ANXA13 Gene

Sources for ANXA13 Gene

Back to Top

Content