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Aliases for ANXA13 Gene

Aliases for ANXA13 Gene

  • Annexin A13 2 3 5
  • Intestine-Specific Annexin 3 4
  • Annexin XIII 3 4
  • Annexin-13 3 4
  • ANX13 3 4
  • ISA 3 4
  • Annexin, Intestine-Specific 3

External Ids for ANXA13 Gene

Previous HGNC Symbols for ANXA13 Gene

  • ANX13

Previous GeneCards Identifiers for ANXA13 Gene

  • GC08M123834
  • GC08M124750
  • GC08M124361
  • GC08M124649
  • GC08M124762
  • GC08M120019
  • GC08M124693

Summaries for ANXA13 Gene

Entrez Gene Summary for ANXA13 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA13 Gene

ANXA13 (Annexin A13) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and phosphatidylserine binding. An important paralog of this gene is ANXA7.

Gene Wiki entry for ANXA13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA13 Gene

Genomics for ANXA13 Gene

Regulatory Elements for ANXA13 Gene

Enhancers for ANXA13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ANXA13 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANXA13 Gene

Chromosome:
8
Start:
123,680,794 bp from pter
End:
123,737,407 bp from pter
Size:
56,614 bases
Orientation:
Minus strand

Genomic View for ANXA13 Gene

Genes around ANXA13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA13 Gene

Proteins for ANXA13 Gene

  • Protein details for ANXA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27216-ANX13_HUMAN
    Recommended name:
    Annexin A13
    Protein Accession:
    P27216
    Secondary Accessions:
    • Q9BQR5

    Protein attributes for ANXA13 Gene

    Size:
    316 amino acids
    Molecular mass:
    35415 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANXA13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANXA13 Gene

Post-translational modifications for ANXA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA13 Gene

Antibody Products

No data available for DME Specific Peptides for ANXA13 Gene

Domains & Families for ANXA13 Gene

Gene Families for ANXA13 Gene

Protein Domains for ANXA13 Gene

Suggested Antigen Peptide Sequences for ANXA13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27216

UniProtKB/Swiss-Prot:

ANX13_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
Similarity:
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA13: view

Function for ANXA13 Gene

Molecular function for ANXA13 Gene

GENATLAS Biochemistry:
annexin A13,calcium and phospholipid binding protein

Gene Ontology (GO) - Molecular Function for ANXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005544 calcium-dependent phospholipid binding IEA --
genes like me logo Genes that share ontologies with ANXA13: view
genes like me logo Genes that share phenotypes with ANXA13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANXA13 Gene

Localization for ANXA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA13 Gene

Cell membrane. Note=Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA13 Gene COMPARTMENTS Subcellular localization image for ANXA13 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
cytosol 4
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
golgi apparatus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ANXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane NAS 1530946
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ANXA13: view

Pathways & Interactions for ANXA13 Gene

SuperPathways for ANXA13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation NAS 1530946
genes like me logo Genes that share ontologies with ANXA13: view

No data available for Pathways by source and SIGNOR curated interactions for ANXA13 Gene

Drugs & Compounds for ANXA13 Gene

(1) Drugs for ANXA13 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ANXA13: view

Transcripts for ANXA13 Gene

Unigene Clusters for ANXA13 Gene

Annexin A13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for ANXA13 Gene

GeneLoc Exon Structure for
ANXA13
ECgene alternative splicing isoforms for
ANXA13

Expression for ANXA13 Gene

mRNA expression in normal human tissues for ANXA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA13 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x20.6), Colon - Transverse (x8.0), and Brain - Spinal cord (cervical c-1) (x6.3).

Protein differential expression in normal tissues from HIPED for ANXA13 Gene

This gene is overexpressed in Fetal gut (56.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANXA13 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANXA13 Gene:

ANXA13

SOURCE GeneReport for Unigene cluster for ANXA13 Gene:

Hs.181107

mRNA Expression by UniProt/SwissProt for ANXA13 Gene:

P27216-ANX13_HUMAN
Tissue specificity: Gut specific.
genes like me logo Genes that share expression patterns with ANXA13: view

Primer Products

No data available for Protein tissue co-expression partners for ANXA13 Gene

Orthologs for ANXA13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANXA13 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ANXA13 34
  • 89.54 (n)
  • 90.2 (a)
ANXA13 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa13 34
  • 85.28 (n)
  • 86.69 (a)
Anxa13 16
Anxa13 35
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANXA13 34
  • 99.44 (n)
  • 99.16 (a)
ANXA13 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa13 34
  • 84.15 (n)
  • 86.89 (a)
cow
(Bos Taurus)
Mammalia ANXA13 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANXA13 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANXA13 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANXA13 34
  • 71.26 (n)
  • 72.13 (a)
ANXA13 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA13 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa13 34
  • 65.9 (n)
  • 67.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25115 34
zebrafish
(Danio rerio)
Actinopterygii anxa13 34
  • 58.03 (n)
  • 55.08 (a)
Dr.16504 34
anxa13l 35
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 36
  • 50 (a)
AnnX 36
  • 42 (a)
Anxb11 36
  • 46 (a)
AnnIX 35
  • 48 (a)
OneToMany
AnnX 35
  • 41 (a)
OneToMany
Anxb11 35
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nex-1 36
  • 40 (a)
nex-2 36
  • 46 (a)
nex-1 34
  • 49.06 (n)
  • 42.52 (a)
nex-4 35
  • 25 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os09g0394900 34
  • 48.26 (n)
  • 39.87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4592 35
  • 43 (a)
OneToOne
Species where no ortholog for ANXA13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA13 Gene

ENSEMBL:
Gene Tree for ANXA13 (if available)
TreeFam:
Gene Tree for ANXA13 (if available)

Paralogs for ANXA13 Gene

(15) SIMAP similar genes for ANXA13 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ANXA13: view

Variants for ANXA13 Gene

Sequence variations from dbSNP and Humsavar for ANXA13 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2294013 - 123,698,489(-) GGACC(A/G)TCCCA reference, missense
rs6995099 - 123,698,424(+) GAGGA(C/T)GGACT reference, missense
rs2294015 - 123,684,627(-) GCATA(A/G)TCGTG reference, missense
rs1001741 -- 123,711,455(-) GGAGA(A/C/G)AGCAT intron-variant
rs1080109 -- 123,698,970(+) AGGAC(C/T)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA13 Gene

Variant ID Type Subtype PubMed ID
nsv1032155 CNV loss 25217958
nsv612140 CNV loss 21841781
nsv6373 CNV deletion 18451855
nsv831451 CNV gain+loss 17160897

Variation tolerance for ANXA13 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.51; 85.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANXA13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANXA13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA13 Gene

Disorders for ANXA13 Gene

Relevant External Links for ANXA13

Genetic Association Database (GAD)
ANXA13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANXA13

No disorders were found for ANXA13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA13 Gene

Publications for ANXA13 Gene

  1. Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins. (PMID: 11961095) Iglesias J.M. … Fernandez M.-P. (Mol. Biol. Evol. 2002) 3 4 22 65
  2. Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins. (PMID: 9503022) Morgan R.O. … Fernandez M.P. (Genomics 1998) 2 3 22 65
  3. A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin. (PMID: 1530946) Wice B.M. … Gordon J.I. (J. Cell Biol. 1992) 3 4 22 65
  4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 46 65
  5. Structure-function relationship in annexin A13, the founder member of the vertebrate family of annexins. (PMID: 15813707) Turnay J. … Lizarbe M.A. (Biochem. J. 2005) 3 22 65

Products for ANXA13 Gene

Sources for ANXA13 Gene

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