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Aliases for ANXA11 Gene

Aliases for ANXA11 Gene

  • Annexin A11 2 3 5
  • Calcyclin-Associated Annexin 50 3 4
  • 56 KDa Autoantigen 3 4
  • Annexin XI 3 4
  • Annexin-11 3 4
  • CAP-50 3 4
  • ANX11 3 4
  • Autoantigen, 56-KD 3
  • CAP50 3

External Ids for ANXA11 Gene

Previous HGNC Symbols for ANXA11 Gene

  • ANX11

Previous GeneCards Identifiers for ANXA11 Gene

  • GC10M080871
  • GC10M081136
  • GC10M082046
  • GC10M081579
  • GC10M081904
  • GC10M075758

Summaries for ANXA11 Gene

Entrez Gene Summary for ANXA11 Gene

  • This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]

GeneCards Summary for ANXA11 Gene

ANXA11 (Annexin A11) is a Protein Coding gene. Diseases associated with ANXA11 include Papillary Hidradenoma and Hidradenoma. GO annotations related to this gene include poly(A) RNA binding and calcium-dependent protein binding. An important paralog of this gene is ANXA7.

UniProtKB/Swiss-Prot for ANXA11 Gene

  • Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.

Gene Wiki entry for ANXA11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA11 Gene

Genomics for ANXA11 Gene

Regulatory Elements for ANXA11 Gene

Enhancers for ANXA11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F080153 1.3 Ensembl ENCODE 20.1 +44.1 44146 15.4 PKNOX1 ATF1 ARNT CREB3L1 SIN3A FEZF1 ZNF2 GLIS2 FOS ZNF263 LINC00857 MBL1P ANXA11 PLAC9 ENSG00000272489 MAT1A SFTPD TSPAN14 GC10M080155
GH10F080192 1.6 FANTOM5 ENCODE 9.9 +4.4 4400 16.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 MBL1P LINC00857 MAT1A ANXA11 DYDC2 PLAC9 SH2D4B LOC642361 LOC101929574 TSPAN14
GH10F079936 1.3 FANTOM5 Ensembl ENCODE 11.4 +267.1 267090 4.4 MTA2 MAX TBX21 SMARCA4 EGR1 POLR2A ZNF341 EED IKZF1 ETV6 SFTPD MBL1P ANXA11 SFTPA2 CTSLP6 LINC00857 SFTPD-AS1 NUTM2B BMS1P21
GH10F080143 1.1 Ensembl ENCODE 12.5 +60.5 60549 3.1 KLF17 FEZF1 ZBTB40 RAD21 RFX5 GLIS2 SCRT2 ZNF654 REST ZFP69B LINC00857 ANXA11 PLAC9 TSPAN14 PIR39736
GH10F080170 0.7 ENCODE 18.3 +33.5 33492 3.5 ZNF263 KLF1 ZNF687 NR2F1 DPF2 ZIC2 E2F1 CTBP1 GATA3 KLF9 LINC00857 MBL1P ANXA11 PLAC9 GC10M080155
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANXA11 on UCSC Golden Path with GeneCards custom track

Promoters for ANXA11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000221505 877 2801 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1

Genomic Location for ANXA11 Gene

Chromosome:
10
Start:
80,150,889 bp from pter
End:
80,205,677 bp from pter
Size:
54,789 bases
Orientation:
Minus strand

Genomic View for ANXA11 Gene

Genes around ANXA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA11 Gene

Proteins for ANXA11 Gene

  • Protein details for ANXA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50995-ANX11_HUMAN
    Recommended name:
    Annexin A11
    Protein Accession:
    P50995
    Secondary Accessions:
    • B4DVE7

    Protein attributes for ANXA11 Gene

    Size:
    505 amino acids
    Molecular mass:
    54390 Da
    Quaternary structure:
    • Interacts with S100A6 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis.

    Alternative splice isoforms for ANXA11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANXA11 Gene

Post-translational modifications for ANXA11 Gene

  • Ubiquitination at Lys 214, Lys 264, Lys 271, Lys 378, and Lys 499
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for ANXA11

No data available for DME Specific Peptides for ANXA11 Gene

Domains & Families for ANXA11 Gene

Gene Families for ANXA11 Gene

Protein Domains for ANXA11 Gene

Graphical View of Domain Structure for InterPro Entry

P50995

UniProtKB/Swiss-Prot:

ANX11_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
Similarity:
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA11: view

Function for ANXA11 Gene

Molecular function for ANXA11 Gene

GENATLAS Biochemistry:
annexin A11,calcium and phospholipid binding protein,two alternatively spliced isoforms
UniProtKB/Swiss-Prot Function:
Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.

Gene Ontology (GO) - Molecular Function for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 9268363
GO:0005544 calcium-dependent phospholipid binding IEA --
GO:0008429 phosphatidylethanolamine binding IEA --
GO:0023026 MHC class II protein complex binding IDA 20458337
genes like me logo Genes that share ontologies with ANXA11: view
genes like me logo Genes that share phenotypes with ANXA11: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANXA11 Gene

Localization for ANXA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA11 Gene

Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA11 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
lysosome 5
plasma membrane 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope NAS 12577318
GO:0005654 nucleoplasm NAS 12577318
GO:0005737 cytoplasm IEA,IDA 7508441
GO:0005819 spindle IEA,IDA 12805373
genes like me logo Genes that share ontologies with ANXA11: view

Pathways & Interactions for ANXA11 Gene

SuperPathways for ANXA11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IEP 9188810
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
GO:0051592 response to calcium ion IDA 9188810
genes like me logo Genes that share ontologies with ANXA11: view

No data available for Pathways by source and SIGNOR curated interactions for ANXA11 Gene

Drugs & Compounds for ANXA11 Gene

(1) Drugs for ANXA11 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for ANXA11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANXA11: view

Transcripts for ANXA11 Gene

Unigene Clusters for ANXA11 Gene

Annexin A11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - -
SP13: - -
SP14: - - -
SP15: - - - - - - - -
SP16:
SP17: - - - - - -
SP18: - - - - - - - - - - - -
SP19:
SP20: - - - -

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for ANXA11 Gene

GeneLoc Exon Structure for
ANXA11
ECgene alternative splicing isoforms for
ANXA11

Expression for ANXA11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANXA11 Gene

mRNA differential expression in normal tissues according to GTEx for ANXA11 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for ANXA11 Gene

This gene is overexpressed in Lymph node (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANXA11 Gene



Protein tissue co-expression partners for ANXA11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANXA11 Gene:

ANXA11

SOURCE GeneReport for Unigene cluster for ANXA11 Gene:

Hs.530291
genes like me logo Genes that share expression patterns with ANXA11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ANXA11 Gene

Orthologs for ANXA11 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANXA11 34 35
  • 95.21 (n)
cow
(Bos Taurus)
Mammalia ANXA11 34 35
  • 90.16 (n)
dog
(Canis familiaris)
Mammalia ANXA11 34 35
  • 89.9 (n)
mouse
(Mus musculus)
Mammalia Anxa11 34 16 35
  • 88.89 (n)
rat
(Rattus norvegicus)
Mammalia Anxa11 34
  • 88.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANXA11 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANXA11 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANXA11 34 35
  • 73.17 (n)
lizard
(Anolis carolinensis)
Reptilia ANXA11 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa11 34
  • 67.78 (n)
Str.8682 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.13331 34
zebrafish
(Danio rerio)
Actinopterygii anxa11a 34 35
  • 64.51 (n)
anxa11b 35
  • 62 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1200 34
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 36 34
  • 58.58 (n)
Anxb11 36
  • 49 (a)
AnnX 36
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta ANXB9 34
  • 55.48 (n)
worm
(Caenorhabditis elegans)
Secernentea nex-2 36 35
  • 48 (a)
nex-1 36
  • 41 (a)
nex-3 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
Species where no ortholog for ANXA11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA11 Gene

ENSEMBL:
Gene Tree for ANXA11 (if available)
TreeFam:
Gene Tree for ANXA11 (if available)

Paralogs for ANXA11 Gene

genes like me logo Genes that share paralogs with ANXA11: view

Variants for ANXA11 Gene

Sequence variations from dbSNP and Humsavar for ANXA11 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10466226 -- 80,164,299(+) AGGGC(A/G)TCAGC intron-variant
rs10466227 -- 80,164,401(+) AGCAT(C/T)AGAGA intron-variant
rs10466228 -- 80,164,617(+) ACAAC(A/G)AGGAT intron-variant
rs1049550 -- 80,166,946(-) GGAGT(C/T)GCTCC reference, missense
rs10616282 -- 80,176,737(+) CTCGT(-/GGA)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA11 Gene

Variant ID Type Subtype PubMed ID
nsv551635 CNV loss 21841781
nsv1141879 OTHER inversion 24896259
esv3623947 CNV gain 21293372
esv3623946 CNV loss 21293372

Variation tolerance for ANXA11 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.56; 97.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANXA11 Gene

Human Gene Mutation Database (HGMD)
ANXA11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANXA11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA11 Gene

Disorders for ANXA11 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ANXA11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
papillary hidradenoma
hidradenoma
  • hidradenoma morphology
rectum adenocarcinoma
  • adenocarcinoma of rectum
hypersensitivity reaction type iv disease
  • immunoproliferative disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANXA11

Genetic Association Database (GAD)
ANXA11
Human Genome Epidemiology (HuGE) Navigator
ANXA11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANXA11
genes like me logo Genes that share disorders with ANXA11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA11 Gene

Publications for ANXA11 Gene

  1. The 56K autoantigen is identical to human annexin XI. (PMID: 7508441) Misaki Y. … van Venrooij W.J. (J. Biol. Chem. 1994) 2 3 4 22 64
  2. Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PMID: 18256029) Shibata H. … Maki M. (J. Biol. Chem. 2008) 3 4 22 64
  3. Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. (PMID: 19165924) Hofmann S. … Schreiber S. (Nat. Genet. 2008) 3 22 46 64
  4. Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display. (PMID: 12805373) Farnaes L. … Ditzel H.J. (J. Biol. Chem. 2003) 3 4 22 64
  5. ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner. (PMID: 11883939) Satoh H. … Maki M. (Biochem. Biophys. Res. Commun. 2002) 3 4 22 64

Products for ANXA11 Gene

Sources for ANXA11 Gene

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