Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANXA11 Gene

Aliases for ANXA11 Gene

  • Annexin A11 2 3 5
  • Calcyclin-Associated Annexin 50 3 4
  • 56 KDa Autoantigen 3 4
  • Annexin XI 3 4
  • Annexin-11 3 4
  • CAP-50 3 4
  • ANX11 3 4
  • Autoantigen, 56-KD 3
  • CAP50 3

External Ids for ANXA11 Gene

Previous HGNC Symbols for ANXA11 Gene

  • ANX11

Previous GeneCards Identifiers for ANXA11 Gene

  • GC10M080871
  • GC10M081136
  • GC10M082046
  • GC10M081579
  • GC10M081904
  • GC10M075758

Summaries for ANXA11 Gene

Entrez Gene Summary for ANXA11 Gene

  • This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]

GeneCards Summary for ANXA11 Gene

ANXA11 (Annexin A11) is a Protein Coding gene. Diseases associated with ANXA11 include papillary hidradenoma and taeniasis. GO annotations related to this gene include poly(A) RNA binding and calcium-dependent protein binding. An important paralog of this gene is ANXA4.

UniProtKB/Swiss-Prot for ANXA11 Gene

  • Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.

Gene Wiki entry for ANXA11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA11 Gene

Genomics for ANXA11 Gene

Regulatory Elements for ANXA11 Gene

Genomic Location for ANXA11 Gene

Chromosome:
10
Start:
80,150,889 bp from pter
End:
80,205,677 bp from pter
Size:
54,789 bases
Orientation:
Minus strand

Genomic View for ANXA11 Gene

Genes around ANXA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA11 Gene

Proteins for ANXA11 Gene

  • Protein details for ANXA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50995-ANX11_HUMAN
    Recommended name:
    Annexin A11
    Protein Accession:
    P50995
    Secondary Accessions:
    • B4DVE7

    Protein attributes for ANXA11 Gene

    Size:
    505 amino acids
    Molecular mass:
    54390 Da
    Quaternary structure:
    • Interacts with S100A6 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis.

    Alternative splice isoforms for ANXA11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANXA11 Gene

Proteomics data for ANXA11 Gene at MOPED

Post-translational modifications for ANXA11 Gene

  • Ubiquitination at Lys 214, Lys 264, Lys 271, Lys 378, and Lys 499
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ANXA11 Gene

Domains & Families for ANXA11 Gene

Gene Families for ANXA11 Gene

Protein Domains for ANXA11 Gene

Graphical View of Domain Structure for InterPro Entry

P50995

UniProtKB/Swiss-Prot:

ANX11_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
Similarity:
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA11: view

Function for ANXA11 Gene

Molecular function for ANXA11 Gene

GENATLAS Biochemistry:
annexin A11,calcium and phospholipid binding protein,two alternatively spliced isoforms
UniProtKB/Swiss-Prot Function:
Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.

Gene Ontology (GO) - Molecular Function for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9268363
GO:0044548 S100 protein binding IPI 12577318
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0048306 calcium-dependent protein binding IPI 11883939
genes like me logo Genes that share ontologies with ANXA11: view
genes like me logo Genes that share phenotypes with ANXA11: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANXA11 Gene

Localization for ANXA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA11 Gene

Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA11 Gene COMPARTMENTS Subcellular localization image for ANXA11 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
lysosome 5
nucleus 5
vacuole 5
cytosol 4
mitochondrion 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope NAS 12577318
GO:0005654 nucleoplasm NAS 12577318
GO:0005737 cytoplasm IDA 7508441
GO:0005819 spindle IDA 12805373
GO:0030496 midbody IDA 15197175
genes like me logo Genes that share ontologies with ANXA11: view

Pathways & Interactions for ANXA11 Gene

SuperPathways for ANXA11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANXA11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANXA11 Gene

Drugs & Compounds for ANXA11 Gene

(1) Drugs for ANXA11 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for ANXA11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANXA11: view

Transcripts for ANXA11 Gene

Unigene Clusters for ANXA11 Gene

Annexin A11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - -
SP13: - -
SP14: - - -
SP15: - - - - - - - -
SP16:
SP17: - - - - - -
SP18: - - - - - - - - - - - -
SP19:
SP20: - - - -

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for ANXA11 Gene

GeneLoc Exon Structure for
ANXA11
ECgene alternative splicing isoforms for
ANXA11

Expression for ANXA11 Gene

mRNA expression in normal human tissues for ANXA11 Gene

mRNA differential expression in normal tissues according to GTEx for ANXA11 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for ANXA11 Gene

This gene is overexpressed in Lymph node (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA11 Gene



SOURCE GeneReport for Unigene cluster for ANXA11 Gene Hs.530291

genes like me logo Genes that share expression patterns with ANXA11: view

Protein tissue co-expression partners for ANXA11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ANXA11 Gene

Orthologs for ANXA11 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANXA11 36
  • 99 (a)
OneToOne
ANXA11 35
  • 95.21 (n)
  • 94.29 (a)
cow
(Bos Taurus)
Mammalia ANXA11 36
  • 87 (a)
OneToOne
ANXA11 35
  • 90.16 (n)
  • 93.29 (a)
dog
(Canis familiaris)
Mammalia ANXA11 35
  • 89.9 (n)
  • 93.43 (a)
ANXA11 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa11 36
  • 93 (a)
OneToOne
Anxa11 16
Anxa11 35
  • 88.89 (n)
  • 93.21 (a)
oppossum
(Monodelphis domestica)
Mammalia ANXA11 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANXA11 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa11 35
  • 88.39 (n)
  • 94.06 (a)
chicken
(Gallus gallus)
Aves ANXA11 35
  • 73.17 (n)
  • 81.6 (a)
ANXA11 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA11 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13331 35
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa11 35
  • 67.78 (n)
  • 74.16 (a)
Str.8682 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1200 35
zebrafish
(Danio rerio)
Actinopterygii anxa11a 35
  • 64.51 (n)
  • 69.86 (a)
anxa11a 36
  • 60 (a)
OneToMany
anxa11b 36
  • 62 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta ANXB9 35
  • 55.48 (n)
  • 52.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 37
  • 52 (a)
AnnX 37
  • 46 (a)
Anxb11 37
  • 49 (a)
AnnIX 35
  • 58.58 (n)
  • 55.66 (a)
worm
(Caenorhabditis elegans)
Secernentea nex-2 36
  • 41 (a)
OneToMany
nex-1 37
  • 41 (a)
nex-2 37
  • 48 (a)
nex-3 37
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for ANXA11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA11 Gene

ENSEMBL:
Gene Tree for ANXA11 (if available)
TreeFam:
Gene Tree for ANXA11 (if available)

Paralogs for ANXA11 Gene

genes like me logo Genes that share paralogs with ANXA11: view

Variants for ANXA11 Gene

Sequence variations from dbSNP and Humsavar for ANXA11 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1049550 - 80,166,946(-) GGAGT(C/G/T)GCTCC reference, missense
rs1802932 - 80,157,730(-) TTCGC(A/G)TCATG reference, missense
rs2229554 - 80,167,303(-) AAGCC(A/G)AGGCA reference, missense
rs751740 -- 80,152,423(+) GGATC(C/T)CTTGG downstream-variant-500B
rs751741 -- 80,152,558(+) aggtt(C/T)gaggg downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ANXA11 Gene

Variant ID Type Subtype PubMed ID
nsv895801 CNV Gain 21882294

Variation tolerance for ANXA11 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.56; 97.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANXA11 Gene

HapMap Linkage Disequilibrium report
ANXA11
Human Gene Mutation Database (HGMD)
ANXA11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA11 Gene

Disorders for ANXA11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANXA11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
papillary hidradenoma
taeniasis
  • beef tapeworm infection
cysticercosis
  • taeniasis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANXA11

Genetic Association Database (GAD)
ANXA11
Human Genome Epidemiology (HuGE) Navigator
ANXA11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANXA11
genes like me logo Genes that share disorders with ANXA11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA11 Gene

Publications for ANXA11 Gene

  1. The 56K autoantigen is identical to human annexin XI. (PMID: 7508441) Misaki Y. … van Venrooij W.J. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins. (PMID: 9503022) Morgan R.O. … Fernandez M.P. (Genomics 1998) 2 3 23
  3. Suppression of annexin A11 in ovarian cancer: implications in chemoresistance. (PMID: 19484149) Song J. … Zhang Z. (Neoplasia 2009) 3 23
  4. Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PMID: 18256029) Shibata H. … Maki M. (J. Biol. Chem. 2008) 3 23
  5. Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. (PMID: 19165924) Hofmann S. … Schreiber S. (Nat. Genet. 2008) 3 23

Products for ANXA11 Gene

Sources for ANXA11 Gene

Back to Top

Content