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ANXA11 Gene

protein-coding   GIFtS: 65
GCID: GC10M081904

Annexin A11


(Previous symbol: ANX11)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Annexin A111 2     CAP-502 3
ANX111 2 3 5     CAP502
Annexin XI2 3     annexin-112
Calcyclin-Associated Annexin 502 3     Autoantigen, 56-KD2
56 KDa Autoantigen2 3     Annexin-113

External Ids:    HGNC: 5351   Entrez Gene: 3112   Ensembl: ENSG000001223597   OMIM: 6025725   UniProtKB: P509953   

Export aliases for ANXA11 gene to outside databases

Previous GC identifers: GC10M080871 GC10M081136 GC10M082046 GC10M081579 GC10M075758


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANXA11 Gene:
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins.
Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent
phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various
autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. (provided
by RefSeq, May 2013)

GeneCards Summary for ANXA11 Gene:
ANXA11 (annexin A11) is a protein-coding gene. GO annotations related to this gene include calcium-dependent phospholipid binding and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANX11_HUMAN, P50995
Function: Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody
formation and completion of the terminal phase of cytokinesis

Gene Wiki entry for ANXA11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANXA11 gene promoter:
         GR   GR-beta   Bach2   GR-alpha   IRF-1   Arnt   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANXA11 promoter sequence
   Search Chromatin IP Primers for ANXA11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANXA11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23   Ensembl cytogenetic band:  10q22.3   HGNC cytogenetic band: 10q22.3

ANXA11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA11 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M081904:  view genomic region     (about GC identifiers)

Start:
81,910,645 bp from pter      End:
81,965,328 bp from pter
Size:
54,684 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANX11_HUMAN, P50995 (See protein sequence)
Recommended Name: Annexin A11  
Size: 505 amino acids; 54390 Da
Subunit: Interacts with S100A6 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with
KIF23 during cytokinesis

Explore the universe of human proteins at neXtProt for ANXA11: NX_P50995

Explore proteomics data for ANXA11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys214, Lys264, Lys271, Lys378, Lys499
  • Modification sites at PhosphoSitePlus

  • See ANXA11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001148.1  NP_001265336.1  NP_001265337.1  NP_001265338.1  NP_665875.1  NP_665876.1  

    ENSEMBL proteins: 
     ENSP00000361305   ENSP00000398610   ENSP00000404412   ENSP00000405009   ENSP00000414642  
     ENSP00000353827   ENSP00000265447   ENSP00000441748   ENSP00000441400  

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    Cloud-Clone Corp. Proteins for ANXA11

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANXA: Annexins

    4 InterPro protein domains:
     IPR008157 AnnexinXI
     IPR018502 Annexin_repeat
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS

    Graphical View of Domain Structure for InterPro Entry P50995

    ProtoNet protein and cluster: P50995

    1 Blocks protein domain: IPB001464 Annexin

    UniProtKB/Swiss-Prot: ANX11_HUMAN, P50995
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    Find genes that share domains with ANXA11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANX11_HUMAN, P50995
    Function: Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody
    formation and completion of the terminal phase of cytokinesis

         Genatlas biochemistry entry for ANXA11:
    annexin A11,calcium and phospholipid binding protein,two alternatively spliced isoforms

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI12445460
    GO:0005544calcium-dependent phospholipid binding IEA--
    GO:0008429phosphatidylethanolamine binding IEA--
    GO:0023026MHC class II protein complex binding IDA--
         
    Find genes that share ontologies with ANXA11           About GenesLikeMe


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target ANXA11:
    hsa-mir-1301-3p (MIRT035979), hsa-mir-124-3p (MIRT022375), hsa-mir-7-5p (MIRT025684), hsa-mir-320a (MIRT044728), hsa-mir-92a-3p (MIRT049835), hsa-mir-25-3p (MIRT050326), hsa-mir-335-5p (MIRT017220), hsa-mir-484 (MIRT042064), hsa-mir-122-5p (MIRT003084), hsa-mir-324-3p (MIRT042901)

    Block miRNA regulation of human, mouse, rat ANXA11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANXA11 (see all 22):
    hsa-miR-3910 hsa-miR-146b-3p hsa-miR-181c hsa-miR-548v hsa-miR-1271 hsa-miR-520a-5p hsa-miR-124 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidANXA11 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANX11_HUMAN, P50995: Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton,
    spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic
    apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the
    nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle
    dependent
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    lysosome5
    nucleus5
    vacuole5
    cytosol2
    endoplasmic reticulum1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope NAS12577318
    GO:0005654nucleoplasm NAS12577318
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with ANXA11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANXA11
    Interactions:

        GeneGlobe Interaction Network for ANXA11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANXA11 (P509952, 3 ENSP000002654474) via UniProtKB, MINT, STRING, and/or I2D (see all 593)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156452, 3MINT-7947479 I2D: score=1 
    UBA5Q9GZZ92, 3MINT-7947479 I2D: score=1 
    ENSG00000206308P019033, ENSP000003727464I2D: score=1 STRING: ENSP00000372746
    ENSG00000226260P019033I2D: score=1 
    ENSG00000227993P019033I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis IEP9188810
    GO:0007109cytokinesis, completion of separation IMP15197175
    GO:0051592response to calcium ion IDA12601007

    Find genes that share ontologies with ANXA11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANXA11 (ANX11)

    1 HMDB Compound for ANXA11    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for ANXA11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phospholipid 34.8 3 1299619 (1), 7508441 (1)
    calcium 9.68 7 9188810 (3), 12805373 (2), 8639854 (1)



    Find genes that share compounds with ANXA11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANXA11 gene (6 alternative transcripts): 
    NM_001157.2  NM_001278407.1  NM_001278408.1  NM_001278409.1  NM_145868.1  NM_145869.1  

    Unigene Cluster for ANXA11:

    Annexin A11
    Hs.530291  [show with all ESTs]
    Unigene Representative Sequence: NM_145869
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372231(uc001kbt.1) ENST00000438331(uc001kbr.1) ENST00000422982(uc001kbs.1 uc010qly.1)
    ENST00000463340 ENST00000447489 ENST00000481805 ENST00000437799 ENST00000463657
    ENST00000474545 ENST00000360615 ENST00000265447(uc010qlx.1) ENST00000535999(uc001kbq.1)
    ENST00000537102
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ANXA11 (see all 22):
    hsa-miR-3910 hsa-miR-146b-3p hsa-miR-181c hsa-miR-548v hsa-miR-1271 hsa-miR-520a-5p hsa-miR-124 hsa-miR-204
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      QuantiTect SYBR Green Assays in human, mouse, rat ANXA11
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    Additional mRNA sequence: 

    AB209770.1 AJ278463.1 AJ278464.1 AJ278465.1 AK000567.1 AK056107.1 AK126287.1 AK222918.1 
    AK298362.1 AK300509.1 AK301047.1 AL357617.1 BC007564.2 BT019934.1 CR450323.1 L19605.1 

    Selected DOTS entries (see all 37):

    DT.449904  DT.75182037  DT.100849032  DT.95208551  DT.100849034  DT.100849033  DT.100849011  DT.100697284 
    DT.121246178  DT.92458913  DT.92458908  DT.121246149  DT.101985389  DT.95373951  DT.91870206  DT.100849009 
    DT.121246298  DT.97860541  DT.100849014  DT.100849028  DT.100849030  DT.91656372  DT.91794085  DT.92458920 

    Selected AceView cDNA sequences (see all 816):

    AA330804 H93242 AW316919 H52252 BM811116 BM678749 CA434409 BF969328 
    CA439728 BF969970 H81555 AI474506 BU154958 AA292927 BQ064069 BG760902 
    NM_145868 CR591981 BG530433 CB119882 AA421635 BU619120 AI478734 AA664142 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANXA11 (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
    SP1:                          -     -     -     -     -     -     -     -                       -           -     -                                             
    SP2:                          -     -     -     -     -     -     -     -     -     -           -           -     -                                             
    SP3:                          -     -     -     -     -     -     -     -     -     -     -     -           -     -                                             
    SP4:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                          -     -     -     -     -     -     -     -     -     -     -     -           -     -                 -     -     -               

    ExUns: 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
    SP1:              -                       -                                                         
    SP2:              -                       -                                                         
    SP3:              -                       -                                                         
    SP4:  -     -     -     -                 -                                                         
    SP5:              -                                                                                 


    ECgene alternative splicing isoforms for ANXA11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANXA11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTCTCGCA
    ANXA11 Expression
    About this image


    ANXA11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
             Bone Marrow
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Kidney (Urinary System)
             Metanephros
    ANXA11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANXA11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530291
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANXA11 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anxa111 , 5 annexin A111, 5 88.89(n)1
    93.21(a)1
      14 (15.06 cM)5
    117441  NM_013469.21  NP_038497.21 
     258421565 
    chicken
    (Gallus gallus)
    Aves ANXA111 annexin A11 73.17(n)
    81.6(a)
      423637  NM_001012903.2  NP_001012921.2 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA116
    annexin A11
    74(a)
    1 ↔ 1
    GL343495.1(277505-338133)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.133312 Xenopus laevis transcribed sequence with weak similarity more 76.6(n)    BU906951.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anxa11a2 annexin A11a 78.43(n)   368215  AY178801.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AnnIX1 , 3 actin binding3
    Annexin IX1
    52(a)
    (best of 3)3
    58.58(n)1
    55.66(a)1
      93B103
    424921  NM_001275867.11  NP_001262796.11 
    worm
    (Caenorhabditis elegans)
    Secernentea nex-23 Annexin 48(a)
    (best of 3)
      III(10397630-10399688)   --


    ENSEMBL Gene Tree for ANXA11 (if available)
    TreeFam Gene Tree for ANXA11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANXA11 gene
    ANXA32  ANXA62  ANXA52  ANXA12  ANXA92  ANXA22  ANXA72  ANXA82  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA11 using alignment to 7 protein entries:     ANX11_HUMAN (see all proteins):
    DKFZp686H02120    ANXA4    ANXA8L2    ANXA5    ANXA6    ANXA3
    ANXA13    ANXA2P2    ANXA10    ANXA8    ANXA1    ANXA7
    ANXA2    ANXA9    ANXA8L1

    Find genes that share paralogs with ANXA11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANXA11 (see all 1234)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs359149861,2
    C--81914579(+) ACACA-/CCCTTC 3 -- ds50010--------
    rs351760361,2
    C,F--81914735(+) CCTTAC/TGAGTC 3 -- ds50015Minor allele frequency- T:0.04NA 128
    rs37482421,2
    C,F,H--81914787(-) CTTACG/ATAGAG 3 -- ds5001 ese328Minor allele frequency- A:0.13EA NA NS 4356
    rs1415348061,2
    C--81914923(+) TGTGG-/AAACAA 3 -- ut310--------
    rs559652411,2
    C--81915055(+) GCCCTT/-TTTTT 3 -- ut311Minor allele frequency- -:0.50NA 2
    rs27896861,2
    C,F,A,H--81915136(+) CTACCC/TTCTCA 3 -- ut31 ese330Minor allele frequency- T:0.16NA NS EA WA CSA 2662
    rs764870071,2
    C,F--81915144(+) TCAGGC/TACGCC 3 -- ut311Minor allele frequency- T:0.06WA 118
    rs1916249861,2
    --81915167(+) CTCAGC/TGAGGA 3 -- ut310--------
    rs1407236411,2
    C--81915173(+) GAGGAC/TACGGT 3 -- ut310--------
    rs31902331,2
    C,F--81915185(-) GGTGGG/TTGAAG 3 -- ut314Minor allele frequency- T:0.02MN NA 308

    HapMap Linkage Disequilibrium report for ANXA11 (81910645 - 81965328 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ANXA11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895801CNV Gain21882294

    Human Gene Mutation Database (HGMD): ANXA11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANXA11
    DNA2.0 Custom Variant and Variant Library Synthesis for ANXA11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602572    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ANXA11:
    Sarcoidosis

    Find genes that share disorders with ANXA11           About GenesLikeMe

    6 Novoseek inferred disease relationships for ANXA11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sclerosis systemic 34.2 1 7699691 (1)
    autoimmune diseases 32 8 11035417 (3), 7699691 (3), 12805373 (1)
    lupus erythematosus systemic 28.3 1 7699691 (1)
    rheumatoid arthritis 17.9 1 7699691 (1)
    tumors 0 4 17982121 (2), 19422301 (1), 19484149 (1)
    cancer 0 1 17982121 (1)

    Genetic Association Database (GAD): ANXA11
    Human Genome Epidemiology (HuGE) Navigator: ANXA11 (6 documents)

    Export disorders for ANXA11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANXA11 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with ANXA11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The 56K autoantigen is identical to human annexin XI. (PubMed id 7508441)1, 2, 3, 9 Misaki Y.... van Venrooij W.J. (J. Biol. Chem. 1994)
    2. Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display. (PubMed id 12805373)1, 2, 9 Farnaes L. and Ditzel H.J. (J. Biol. Chem. 2003)
    3. Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. (PubMed id 19165924)1, 4, 9 Hofmann S....Schreiber S. (Nat. Genet. 2008)
    4. ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner. (PubMed id 11883939)1, 2, 9 Satoh H.... Maki M. (Biochem. Biophys. Res. Commun. 2002)
    5. Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms. (PubMed id 11013079)1, 2, 9 Bances P....Fernandez M.-P. (Genomics 2000)
    6. Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins. (PubMed id 9503022)1, 3, 9 Morgan R.O....Fernandez M.P. (Genomics 1998)
    7. Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PubMed id 18256029)1, 2, 9 Shibata H....Maki M. (J. Biol. Chem. 2008)
    8. First independent replication study confirms the strong genetic association of ANXA11 with sarcoidosis. (PubMed id 20805159)1, 4 Li Y....Wollnik B. (Thorax 2010)
    9. Polymorphisms in the Annexin gene family and the risk of osteonecrosis of the femoral head in the Korean population. (PubMed id 19345290)1, 4 Kim T.H....Kim S.Y. (Bone 2009)
    10. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 311 HGNC: 535 AceView: ANXA11 Ensembl:ENSG00000122359 euGenes: HUgn311
    ECgene: ANXA11 H-InvDB: ANXA11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANXA11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANXA11 gene:
    Search GeneIP for patents involving ANXA11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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