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Aliases for ANXA11 Gene

Aliases for ANXA11 Gene

  • Annexin A11 2 3
  • ANX11 3 4 6
  • Calcyclin-Associated Annexin 50 3 4
  • 56 KDa Autoantigen 3 4
  • Annexin XI 3 4
  • Annexin-11 3 4
  • CAP-50 3 4
  • Autoantigen, 56-KD 3
  • CAP50 3

External Ids for ANXA11 Gene

Previous Symbols for ANXA11 Gene

  • ANX11

Summaries for ANXA11 Gene

Entrez Gene Summary for ANXA11 Gene

  • This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, May 2013]

GeneCards Summary for ANXA11 Gene

ANXA11 (Annexin A11) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA9.

UniProtKB/Swiss-Prot for ANXA11 Gene

  • Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.

Gene Wiki entry for ANXA11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA11 Gene

Genomics for ANXA11 Gene

Genomic Location for ANXA11 Gene

Start:
80,150,889 bp from pter
End:
80,205,677 bp from pter
Size:
54,789 bases
Orientation:
Minus strand

Genomic View for ANXA11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANXA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA11 Gene

Regulatory Elements for ANXA11 Gene

Proteins for ANXA11 Gene

  • Protein details for ANXA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50995-ANX11_HUMAN
    Recommended name:
    Annexin A11
    Protein Accession:
    P50995
    Secondary Accessions:
    • B4DVE7

    Protein attributes for ANXA11 Gene

    Size:
    505 amino acids
    Molecular mass:
    54390 Da
    Quaternary structure:
    • Interacts with S100A6 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis.

    Alternative splice isoforms for ANXA11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANXA11 Gene

Proteomics data for ANXA11 Gene at MOPED

Post-translational modifications for ANXA11 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys214, Lys264, Lys271, Lys378, and Lys499

No data available for DME Specific Peptides for ANXA11 Gene

Domains for ANXA11 Gene

Gene Families for ANXA11 Gene

HGNC:

Protein Domains for ANXA11 Gene

UniProtKB/Swiss-Prot:

ANX11_HUMAN
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid:
    • P50995
Family:
  • Belongs to the annexin family.:
    • P50995
Similarity:
  • Contains 4 annexin repeats.:
    • P50995
genes like me logo Genes that share domains with ANXA11: view

Function for ANXA11 Gene

Molecular function for ANXA11 Gene

GENATLAS Biochemistry: annexin A11,calcium and phospholipid binding protein,two alternatively spliced isoforms
UniProtKB/Swiss-Prot Function: Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.

Gene Ontology (GO) - Molecular Function for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 12445460
GO:0005544 calcium-dependent phospholipid binding IEA --
GO:0008429 phosphatidylethanolamine binding IEA --
GO:0023026 MHC class II protein complex binding IDA 20458337
genes like me logo Genes that share ontologies with ANXA11: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANXA11 Gene

Localization for ANXA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA11 Gene

Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA11 Gene COMPARTMENTS Subcellular localization image for ANXA11 gene
Compartment Confidence
cytoskeleton 5
lysosome 5
nucleus 5
vacuole 5
cytosol 2
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope NAS 12577318
GO:0005654 nucleoplasm NAS 12577318
GO:0005737 cytoplasm IDA --
GO:0005819 spindle IDA 12805373
genes like me logo Genes that share ontologies with ANXA11: view

Pathways for ANXA11 Gene

SuperPathways for ANXA11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IEP 9188810
GO:0007049 cell cycle IEA --
GO:0007109 cytokinesis, completion of separation --
GO:0051301 cell division IEA --
GO:0051592 response to calcium ion IDA 12601007
genes like me logo Genes that share ontologies with ANXA11: view

No data available for Pathways by source for ANXA11 Gene

Compounds for ANXA11 Gene

(1) HMDB Compounds for ANXA11 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(2) Novoseek inferred chemical compound relationships for ANXA11 Gene

Compound -log(P) Hits PubMed IDs
phospholipid 34.8 2
calcium 9.68 6
genes like me logo Genes that share compounds with ANXA11: view

Transcripts for ANXA11 Gene

Unigene Clusters for ANXA11 Gene

Annexin A11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - -
SP13: - -
SP14: - - -
SP15: - - - - - - - -
SP16:
SP17: - - - - - -
SP18: - - - - - - - - - - - -
SP19:
SP20: - - - -

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for ANXA11 Gene

GeneLoc Exon Structure for
ANXA11
ECgene alternative splicing isoforms for
ANXA11

Expression for ANXA11 Gene

mRNA expression in normal human tissues for ANXA11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA11 Gene

This gene is overexpressed in Whole Blood (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA11 Gene

SOURCE GeneReport for Unigene cluster for ANXA11 Gene Hs.530291

genes like me logo Genes that share expressions with ANXA11: view

Orthologs for ANXA11 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANXA11 36
  • 95.21 (n)
  • 94.29 (a)
ANXA11 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANXA11 36
  • 90.16 (n)
  • 93.29 (a)
ANXA11 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA11 36
  • 89.9 (n)
  • 93.43 (a)
ANXA11 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa11 36
  • 88.89 (n)
  • 93.21 (a)
Anxa11 16
Anxa11 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANXA11 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANXA11 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa11 36
  • 88.39 (n)
  • 94.06 (a)
chicken
(Gallus gallus)
Aves ANXA11 36
  • 73.17 (n)
  • 81.6 (a)
ANXA11 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA11 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13331 36
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa11 36
  • 67.78 (n)
  • 74.16 (a)
Str.8682 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1200 36
zebrafish
(Danio rerio)
Actinopterygii anxa11a 36
  • 64.51 (n)
  • 69.86 (a)
anxa11a 37
  • 60 (a)
OneToMany
anxa11b 37
  • 62 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta ANXB9 36
  • 55.48 (n)
  • 52.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 36
  • 58.58 (n)
  • 55.66 (a)
Anxb11 38
  • 49 (a)
AnnIX 38
  • 52 (a)
AnnX 38
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea nex-2 37
  • 41 (a)
OneToMany
nex-1 38
  • 41 (a)
nex-3 38
  • 36 (a)
nex-2 38
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
OneToMany
Species with no ortholog for ANXA11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA11 Gene

ENSEMBL:
Gene Tree for ANXA11 (if available)
TreeFam:
Gene Tree for ANXA11 (if available)

Paralogs for ANXA11 Gene

Paralogs for ANXA11 Gene

genes like me logo Genes that share paralogs with ANXA11: view

Variants for ANXA11 Gene

Sequence variations from dbSNP and Humsavar for ANXA11 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs734965 -- 80,202,014(-) TCTGG(A/G)ATCTC intron-variant, upstream-variant-2KB
rs1049550 - 80,166,946(-) GGAGT(C/T)GCTCC reference, missense
rs1079242 -- 80,157,952(+) TGCAC(A/G)TGGAA intron-variant
rs1802932 - 80,157,730(-) TTCGC(A/G)TCATG reference, missense
rs1802934 -- 80,155,772(-) TCTAA(A/C)AAATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ANXA11 Gene

Variant ID Type Subtype PubMed ID
nsv895801 CNV Gain 21882294

Relevant External Links for ANXA11 Gene

HapMap Linkage Disequilibrium report
ANXA11
Human Gene Mutation Database (HGMD)
ANXA11

Disorders for ANXA11 Gene

(1) University of Copenhagen DISEASES for ANXA11 Gene

(6) Novoseek inferred disease relationships for ANXA11 Gene

Disease -log(P) Hits PubMed IDs
sclerosis systemic 34.2 1
autoimmune diseases 32 7
lupus erythematosus systemic 28.3 1
rheumatoid arthritis 17.9 1
tumors 0 4

Relevant External Links for ANXA11

Genetic Association Database (GAD)
ANXA11
Human Genome Epidemiology (HuGE) Navigator
ANXA11
genes like me logo Genes that share disorders with ANXA11: view

No data available for UniProtKB/Swiss-Prot for ANXA11 Gene

Publications for ANXA11 Gene

  1. The 56K autoantigen is identical to human annexin XI. (PMID: 7508441) Misaki Y. … van Venrooij W.J. (J. Biol. Chem. 1994) 2 3 4 23
  2. Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins. (PMID: 9503022) Morgan R.O. … Fernandez M.P. (Genomics 1998) 2 3 23
  3. Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms. (PMID: 11013079) Bances P. … Fernandez M.-P. (Genomics 2000) 3 4 23
  4. Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display. (PMID: 12805373) Farnaes L. … Ditzel H.J. (J. Biol. Chem. 2003) 3 4 23
  5. ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner. (PMID: 11883939) Satoh H. … Maki M. (Biochem. Biophys. Res. Commun. 2002) 3 4 23

Products for ANXA11 Gene

Sources for ANXA11 Gene

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