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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANXA11 Gene

protein-coding   GIFtS: 65
GCID: GC10M081904

Annexin A11


(Previous symbol: ANX11)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Annexin A111 2     CAP-502 3
ANX111 2 3 5     CAP502
Annexin XI2 3     annexin-112
Calcyclin-Associated Annexin 502 3     Autoantigen, 56-KD2
56 KDa Autoantigen2 3     Annexin-113

External Ids:    HGNC: 5351   Entrez Gene: 3112   Ensembl: ENSG000001223597   OMIM: 6025725   UniProtKB: P509953   

Export aliases for ANXA11 gene to outside databases

Previous GC identifers: GC10M080871 GC10M081136 GC10M082046 GC10M081579 GC10M075758


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANXA11 Gene:
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins.
Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent
phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various
autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. (provided
by RefSeq, May 2013)

GeneCards Summary for ANXA11 Gene: 
ANXA11 (annexin A11) is a protein-coding gene. Diseases associated with ANXA11 include papillary hidradenoma, and hidradenoma. GO annotations related to this gene include calcium-dependent phospholipid binding and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANX11_HUMAN, P50995
Function: Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody
formation and completion of the terminal phase of cytokinesis

Gene Wiki entry for ANXA11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANXA11 gene promoter:
         GR   GR-beta   Bach2   GR-alpha   IRF-1   Arnt   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANXA11 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANXA11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23   Ensembl cytogenetic band:  10q22.3   HGNC cytogenetic band: 10q22.3

ANXA11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA11 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M081904:  view genomic region     (about GC identifiers)

Start:
81,910,645 bp from pter      End:
81,965,328 bp from pter
Size:
54,684 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANX11_HUMAN, P50995 (See protein sequence)
Recommended Name: Annexin A11  
Size: 505 amino acids; 54390 Da
Subunit: Interacts with S100A6 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with
KIF23 during cytokinesis
Subcellular location: Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton,
spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic
apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the
nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle
dependent

Explore the universe of human proteins at neXtProt for ANXA11: NX_P50995

Explore proteomics data for ANXA11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50995

  • ANXA11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANXA11 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001148.1  NP_001265336.1  NP_001265337.1  NP_001265338.1  NP_665875.1  NP_665876.1  

    ENSEMBL proteins: 
     ENSP00000361305   ENSP00000398610   ENSP00000404412   ENSP00000405009   ENSP00000414642  
     ENSP00000353827   ENSP00000265447   ENSP00000441748   ENSP00000441400  

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    Cloud-Clone Corp. Proteins for ANXA11 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope NAS12577318
    GO:0005654nucleoplasm NAS12577318
    GO:0005737cytoplasm IDA12601007
    GO:0005819spindle IDA12805373
    GO:0030496midbody IDA15197175

    ANXA11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANXA: Annexins

    4 InterPro protein domains:
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR008157 AnnexinXI
     IPR018502 Annexin_repeat

    Graphical View of Domain Structure for InterPro Entry P50995

    ProtoNet protein and cluster: P50995

    1 Blocks protein domain: IPB001464 Annexin

    UniProtKB/Swiss-Prot: ANX11_HUMAN, P50995
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    ANXA11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANX11_HUMAN, P50995
    Function: Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody
    formation and completion of the terminal phase of cytokinesis

         Genatlas biochemistry entry for ANXA11:
    annexin A11,calcium and phospholipid binding protein,two alternatively spliced isoforms

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI12445460
    GO:0005544calcium-dependent phospholipid binding IEA--
    GO:0008429phosphatidylethanolamine binding IEA--
    GO:0044548S100 protein binding IPI12577318
         
    ANXA11 for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidANXA11 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANXA11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/582 Interacting proteins for ANXA11 (P509952, 3 ENSP000002654474) via UniProtKB, MINT, STRING, and/or I2D (see all 582)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156452, 3MINT-7947479 I2D: score=1 
    UBA5Q9GZZ92, 3MINT-7947479 I2D: score=1 
    ENSG00000206308P019033, ENSP000003727464I2D: score=1 STRING: ENSP00000372746
    ENSG00000226260P019033I2D: score=1 
    ENSG00000227993P019033I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis IEP9188810
    GO:0007109cytokinesis, completion of separation IMP15197175
    GO:0051592response to calcium ion IDA12601007

    ANXA11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANXA11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANXA11 (ANX11)

    1 HMDB Compound for ANXA11    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for ANXA11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phospholipid 34.8 3 1299619 (1), 7508441 (1)
    calcium 9.68 7 9188810 (3), 12805373 (2), 8639854 (1)

    Search CenterWatch for drugs/clinical trials and news about ANXA11 / ANX11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANXA11 gene (6 alternative transcripts): 
    NM_001157.2  NM_001278407.1  NM_001278408.1  NM_001278409.1  NM_145868.1  NM_145869.1  

    Unigene Cluster for ANXA11:

    Annexin A11
    Hs.530291  [show with all ESTs]
    Unigene Representative Sequence: NM_145869
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372231(uc001kbt.1) ENST00000438331(uc001kbr.1) ENST00000422982(uc001kbs.1 uc010qly.1)
    ENST00000463340 ENST00000447489 ENST00000481805 ENST00000437799 ENST00000463657
    ENST00000474545 ENST00000360615 ENST00000265447(uc010qlx.1) ENST00000535999(uc001kbq.1)
    ENST00000537102

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    hsa-miR-3910 hsa-miR-146b-3p hsa-miR-181c hsa-miR-548v hsa-miR-1271 hsa-miR-520a-5p hsa-miR-124 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidANXA11 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209770.1 AJ278463.1 AJ278464.1 AJ278465.1 AK000567.1 AK056107.1 AK126287.1 AK222918.1 
    AK298362.1 AK300509.1 AK301047.1 AL357617.1 BC007564.2 BT019934.1 CR450323.1 L19605.1 

    24/37 DOTS entries (see all 37):

    DT.449904  DT.75182037  DT.100849032  DT.95208551  DT.100849034  DT.100849033  DT.100849011  DT.100697284 
    DT.121246178  DT.92458913  DT.92458908  DT.121246149  DT.101985389  DT.95373951  DT.91870206  DT.100849009 
    DT.121246298  DT.97860541  DT.100849014  DT.100849028  DT.100849030  DT.91656372  DT.91794085  DT.92458920 

    24/816 AceView cDNA sequences (see all 816):

    AA985520 NM_145868 BQ686358 BQ064069 AA330804 AK056107 N68939 BM843870 
    AI129242 AA664142 AL527256 CB160030 BQ053996 AA808938 BU733256 NM_145869 
    AA748580 AA197140 CA311967 AW027760 BM842443 H52252 AI027231 BI859946 

    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for ANXA11 (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
    SP1:                          -     -     -     -     -     -     -     -                       -           -     -                                             
    SP2:                          -     -     -     -     -     -     -     -     -     -           -           -     -                                             
    SP3:                          -     -     -     -     -     -     -     -     -     -     -     -           -     -                                             
    SP4:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                          -     -     -     -     -     -     -     -     -     -     -     -           -     -                 -     -     -               

    ExUns: 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
    SP1:              -                       -                                                         
    SP2:              -                       -                                                         
    SP3:              -                       -                                                         
    SP4:  -     -     -     -                 -                                                         
    SP5:              -                                                                                 


    ECgene alternative splicing isoforms for ANXA11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANXA11 expression in normal human tissues (normalized intensities)      ANXA11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTCTCGCA
    ANXA11 Expression
    About this image


    ANXA11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             leukocytes   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             nasopharynx ; respiratory epithelial cells   
             sensory organ/nose/nasal cavity   
     
     Breast
             breast ; myoepithelial cells   

    See ANXA11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANXA11

    SOURCE GeneReport for Unigene cluster: Hs.530291
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ANXA11 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anxa111 , 5 annexin A111, 5 88.93(n)1
    93.24(a)1
      14 (15.06 cM)5
    117441  NM_013469.21  NP_038497.21 
     258421835 
    chicken
    (Gallus gallus)
    Aves ANXA111 annexin A11 74.33(n)
    82.34(a)
      423637  NM_001012903.2  NP_001012921.2 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA116
    annexin A11
    75(a)
    1 ↔ 1
    GL343495.1(277505-338133)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.133312 Xenopus laevis transcribed sequence with weak similarity more 76.6(n)    BU906951.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anxa11a2 annexin A11a 78.43(n)   368215  AY178801.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AnnIX1 , 3 actin binding3
    Annexin IX1
    52(a)
    (best of 3)3
    58.39(n)1
    54.84(a)1
      93B103
    424921  NM_206531.11  NP_996253.11 


    ENSEMBL Gene Tree for ANXA11 (if available)
    TreeFam Gene Tree for ANXA11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANXA11 gene
    ANXA32  ANXA62  ANXA52  ANXA12  ANXA92  ANXA22  ANXA72  ANXA82  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA11 using alignment to 7 protein entries:     ANX11_HUMAN (see all proteins):
    DKFZp686H02120    ANXA4    ANXA8L2    ANXA5    ANXA6    ANXA3
    ANXA13    ANXA2P2    ANXA10    ANXA8L1    ANXA1    ANXA7
    ANXA2    ANXA9    ANXA8

    ANXA11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1234 SNPs in ANXA11 are shown (see all 1234)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs359149861,2
    C--81914579(+) ACACA-/CCCTTC 3 -- ds50010--------
    rs351760361,2
    C,F--81914735(+) CCTTAC/TGAGTC 3 -- ds50015Minor allele frequency- T:0.04NA 128
    rs37482421,2
    C,F,H--81914787(-) CTTACG/ATAGAG 3 -- ds5001 ese328Minor allele frequency- A:0.13EA NA NS 4356
    rs1415348061,2
    C--81914923(+) TGTGG-/AAACAA 3 -- ut310--------
    rs559652411,2
    C--81915055(+) GCCCTT/-TTTTT 3 -- ut311Minor allele frequency- -:0.50NA 2
    rs27896861,2
    C,F,A,H--81915136(+) CTACCC/TTCTCA 3 -- ut31 ese330Minor allele frequency- T:0.16NA NS EA WA CSA 2662
    rs764870071,2
    C,F--81915144(+) TCAGGC/TACGCC 3 -- ut311Minor allele frequency- T:0.06WA 118
    rs1916249861,2
    --81915167(+) CTCAGC/TGAGGA 3 -- ut310--------
    rs1407236411,2
    C--81915173(+) GAGGAC/TACGGT 3 -- ut310--------
    rs31902331,2
    C,F--81915185(-) GGTGGG/TTGAAG 3 -- ut314Minor allele frequency- T:0.02MN NA 308

    HapMap Linkage Disequilibrium report for ANXA11 (81910645 - 81965328 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ANXA11:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv895801CNV Gain21882294


    Human Gene Mutation Database (HGMD): ANXA11
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ANXA11
    DNA2.0 Custom Variant and Variant Library Synthesis for ANXA11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602572    OMIM disorders: --

    12 diseases for ANXA11:    About MalaCards
    papillary hidradenoma    hidradenoma    syringoma    osteonecrosis
    endocarditis    sarcoidosis    pancreatic cancer    lupus erythematosus
    ovarian cancer    alzheimer's disease    pancreatitis    lung cancer

    1 disease from the University of Copenhagen DISEASES database for ANXA11:
    Sarcoidosis

    ANXA11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for ANXA11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sclerosis systemic 34.2 1 7699691 (1)
    autoimmune diseases 32 8 11035417 (3), 7699691 (3), 12805373 (1)
    lupus erythematosus systemic 28.3 1 7699691 (1)
    rheumatoid arthritis 17.9 1 7699691 (1)
    tumors 0 4 17982121 (2), 19422301 (1), 19484149 (1)
    cancer 0 1 17982121 (1)

    Genetic Association Database (GAD): ANXA11
    Human Genome Epidemiology (HuGE) Navigator: ANXA11 (6 documents)

    Export disorders for ANXA11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANXA11 gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with ANXA11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The 56K autoantigen is identical to human annexin XI. (PubMed id 7508441)1, 2, 3, 9 Misaki Y.... van Venrooij W.J. (1994)
    2. Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display. (PubMed id 12805373)1, 2, 9 Farnaes L. and Ditzel H.J. (2003)
    3. Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. (PubMed id 19165924)1, 4, 9 Hofmann S....Schreiber S. (2008)
    4. ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner. (PubMed id 11883939)1, 2, 9 Satoh H.... Maki M. (2002)
    5. Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms. (PubMed id 11013079)1, 2, 9 Bances P....Fernandez M.-P. (2000)
    6. Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins. (PubMed id 9503022)1, 3, 9 Morgan R.O....Fernandez M.P. (1998)
    7. Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PubMed id 18256029)1, 2, 9 Shibata H....Maki M. (2008)
    8. First independent replication study confirms the stro ng genetic association of ANXA11 with sarcoidosis. (PubMed id 20805159)1, 4 Li Y....Wollnik B. (2010)
    9. Polymorphisms in the Annexin gene family and the risk of osteonecrosis of the femoral head in the Korean population. (PubMed id 19345290)1, 4 Kim T.H....Kim S.Y. (2009)
    10. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 311 HGNC: 535 AceView: ANXA11 Ensembl:ENSG00000122359 euGenes: HUgn311
    ECgene: ANXA11 H-InvDB: ANXA11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANXA11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANXA11 gene:
    Search GeneIP for patents involving ANXA11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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