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Aliases for ANXA10 Gene

Aliases for ANXA10 Gene

  • Annexin A10 2 3 5
  • Annexin-10 3 4
  • Annexin-14 3 4
  • ANX14 3 4
  • Annexin 14 3

External Ids for ANXA10 Gene

Previous GeneCards Identifiers for ANXA10 Gene

  • GC04P169783
  • GC04P169435
  • GC04P169598
  • GC04P169709
  • GC04P169388
  • GC04P169250
  • GC04P169013
  • GC04P164764

Summaries for ANXA10 Gene

Entrez Gene Summary for ANXA10 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA10 Gene

ANXA10 (Annexin A10) is a Protein Coding gene. Diseases associated with ANXA10 include lynch syndrome. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA10 Gene

Genomics for ANXA10 Gene

Regulatory Elements for ANXA10 Gene

Genomic Location for ANXA10 Gene

Chromosome:
4
Start:
168,092,515 bp from pter
End:
168,187,742 bp from pter
Size:
95,228 bases
Orientation:
Plus strand

Genomic View for ANXA10 Gene

Genes around ANXA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA10 Gene

Proteins for ANXA10 Gene

  • Protein details for ANXA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ72-ANX10_HUMAN
    Recommended name:
    Annexin A10
    Protein Accession:
    Q9UJ72
    Secondary Accessions:
    • Q96IQ5
    • Q9UJV4

    Protein attributes for ANXA10 Gene

    Size:
    324 amino acids
    Molecular mass:
    37278 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANXA10 Gene

Proteomics data for ANXA10 Gene at MOPED

Post-translational modifications for ANXA10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ANXA10 Gene

Domains & Families for ANXA10 Gene

Gene Families for ANXA10 Gene

Protein Domains for ANXA10 Gene

Suggested Antigen Peptide Sequences for ANXA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJ72

UniProtKB/Swiss-Prot:

ANX10_HUMAN :
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
Family:
  • Belongs to the annexin family.
Similarity:
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA10: view

Function for ANXA10 Gene

Molecular function for ANXA10 Gene

GENATLAS Biochemistry:
annexin A10,progenitor of annexin A6 octad formation via chromosome duplication during early chordate evolution

Gene Ontology (GO) - Molecular Function for ANXA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005544 calcium-dependent phospholipid binding IEA --
genes like me logo Genes that share ontologies with ANXA10: view
genes like me logo Genes that share phenotypes with ANXA10: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANXA10 Gene

Localization for ANXA10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA10 Gene COMPARTMENTS Subcellular localization image for ANXA10 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANXA10 Gene

Pathways & Interactions for ANXA10 Gene

SuperPathways for ANXA10 Gene

No Data Available

Interacting Proteins for ANXA10 Gene

Gene Ontology (GO) - Biological Process for ANXA10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANXA10 Gene

Drugs & Compounds for ANXA10 Gene

No Compound Related Data Available

Transcripts for ANXA10 Gene

Unigene Clusters for ANXA10 Gene

Annexin A10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA10 Gene

No ASD Table

Relevant External Links for ANXA10 Gene

GeneLoc Exon Structure for
ANXA10
ECgene alternative splicing isoforms for
ANXA10

Expression for ANXA10 Gene

mRNA expression in normal human tissues for ANXA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA10 Gene

This gene is overexpressed in Stomach (x39.7) and Liver (x7.1).

Protein differential expression in normal tissues from HIPED for ANXA10 Gene

This gene is overexpressed in Cardia (30.3) and Stomach (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANXA10 Gene



SOURCE GeneReport for Unigene cluster for ANXA10 Gene Hs.188401

genes like me logo Genes that share expression patterns with ANXA10: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ANXA10 Gene

Orthologs for ANXA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANXA10 35
  • 84.88 (n)
  • 86.11 (a)
ANXA10 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA10 35
  • 88.16 (n)
  • 90.88 (a)
ANXA10 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa10 35
  • 87.45 (n)
  • 88.89 (a)
Anxa10 16
Anxa10 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANXA10 35
  • 99.28 (n)
  • 98.46 (a)
ANXA10 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa10 35
  • 85.91 (n)
  • 87.35 (a)
oppossum
(Monodelphis domestica)
Mammalia ANXA10 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANXA10 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANXA10 35
  • 79.42 (n)
  • 82.1 (a)
ANXA10 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa10 35
  • 74.59 (n)
  • 76.85 (a)
zebrafish
(Danio rerio)
Actinopterygii anxa13 36
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nex-1 36
  • 35 (a)
ManyToMany
nex-3 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7864 36
  • 13 (a)
ManyToMany
Species with no ortholog for ANXA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA10 Gene

ENSEMBL:
Gene Tree for ANXA10 (if available)
TreeFam:
Gene Tree for ANXA10 (if available)

Paralogs for ANXA10 Gene

(14) SIMAP similar genes for ANXA10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANXA10: view

Variants for ANXA10 Gene

Sequence variations from dbSNP and Humsavar for ANXA10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs6836994 - 168,162,543(+) GGGAT(A/C)TGAGG reference, missense
rs1320056 -- 168,145,476(-) tcata(C/G/T)gccga intron-variant
rs1344005 -- 168,101,630(-) gtctt(A/C)aatgg intron-variant
rs1317046 -- 168,151,737(+) TATTC(A/G)ATATT intron-variant
rs2292734 -- 168,164,442(-) TAATC(A/G)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA10 Gene

Variant ID Type Subtype PubMed ID
nsv428455 CNV Gain 18775914
dgv1714e1 CNV Complex 17122850
dgv1715e1 CNV Complex 17122850
dgv194e55 CNV Loss 17911159
nsv881050 CNV Loss 21882294
nsv830146 CNV Gain 17160897
dgv5823n71 CNV Loss 21882294
nsv881291 CNV Gain 21882294
nsv881391 CNV Loss 21882294
nsv820236 CNV Gain 19587683
nsv822825 CNV Gain 20364138
nsv521908 CNV Loss 19592680
nsv293790 CNV Loss 16902084

Variation tolerance for ANXA10 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANXA10 Gene

HapMap Linkage Disequilibrium report
ANXA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA10 Gene

Disorders for ANXA10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANXA10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lynch syndrome
  • colorectal cancer, hereditary nonpolyposis, type 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANXA10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANXA10
genes like me logo Genes that share disorders with ANXA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA10 Gene

Publications for ANXA10 Gene

  1. Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution. (PMID: 10458909) Morgan R.O. … Fernandez M.-P. (Genomics 1999) 2 3 4 23 67
  2. Reduced expression and homozygous deletion of annexin A10 in gastric carcinoma. (PMID: 19582876) Kim J. … Kim W.H. (Int. J. Cancer 2009) 3 23
  3. Down-regulation of annexin A10 in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy with p53 mutation. (PMID: 12000734) Liu S.H. … Hsu H.C. (Am. J. Pathol. 2002) 3 23
  4. Annexin A10 is a marker for the serrated pathway of colorectal carcinoma. (PMID: 25395067) Sajanti S.A. … MAokinen M.J. (Virchows Arch. 2015) 3
  5. The tumor suppressor annexin A10 is a novel component of nuclear paraspeckles. (PMID: 23715859) Quiskamp N. … Rescher U. (Cell. Mol. Life Sci. 2014) 3

Products for ANXA10 Gene

Sources for ANXA10 Gene

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