ANXA10 Gene
protein-coding GIFtS : 51
GCID: GC04 P169013
annexin A10
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Aliasesfor ANXA10 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Annexin A10 1 2 Annexin-143 ANX141 2 3 Annexin-103 Annexin 142 Annexin-143 Annexin-103
Export aliases for ANXA10 gene to outside databases Previous GC identifers: GC04P169783 GC04P169435 GC04P169598 GC04P169709 GC04P169388 GC04P169250 GC04P164764
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Summariesfor ANXA10 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ANXA10 : This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The function of this gene has not yet been determined. (provided by RefSeq, Jul 2008)
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Genomic Viewsfor ANXA10 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ANXA10 gene promoter: Oct-B1 oct-B3 oct-B2 GATA-3 Cdc5 FAC1 Nkx6-1 FOXJ2 (long isoform) HFH-1 FOXJ2 Other transcription factors Search SABiosciences Chromatin IP Primers for ANXA10 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA10
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q33 Ensembl cytogenetic band: 4q32.3 HGNC cytogenetic band: 4q32.3 ANXA10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P169013: view genomic region
(about GC identifiers )
Start:
169,013,666 bp from pter
End:
169,108,893 bp from pter
Size:
95,228 bases
Orientation:
plus strand
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Proteinsfor ANXA10 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ANX10_HUMAN, Q9UJ72 (See
protein sequence )Recommended Name: Annexin A10 Size : 324 amino acids; 37278 Da
Secondary accessions : Q96IQ5 Q9UJV4Explore the universe of human proteins at neXtProt for ANXA10: NX_Q9UJ72 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9UJ72 ANXA10 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_009124.2 ENSEMBL proteins: ENSP00000352248 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005739 mitochondrion
IEA --
ANXA10 for ontologies About GeneDecksing ANXA10 Antibody Products: Assay Products for ANXA10:
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Protein
Domains / Familiesfor ANXA10 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ANXA10 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9UJ72 ProtoNet protein and cluster: Q9UJ72
1 Blocks protein family : IPB001464 Annexin UniProtKB/Swiss-Prot: ANX10_HUMAN, Q9UJ72 Similarity : Belongs to the annexin familySimilarity : Contains 4 annexin repeats
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Functionfor ANXA10 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: Genatlas biochemistry entry for ANXA10 : annexin A10,progenitor of annexin A6 octad formation via chromosome duplication during early chordate evolution Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANXA10 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANXA10OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANXA10 (NM_007193 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANXA10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANXA10
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA10
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005509 calcium ion binding
IEA -- GO:0005544 calcium-dependent phospholipid binding
IEA --
ANXA10 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for ANXA10 :
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Pathways & Interactionsfor ANXA10 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANXA10 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)2 Interacting proteins for ANXA10 (Q9UJ72 3 ENSP00000352248 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor ANXA10 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ANXA10 Search CenterWatch for drugs/clinical trials and news about ANXA10 / ANX10
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Transcriptsfor ANXA10 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ANXA10 gene: NM_007193.4 Unigene Cluster for ANXA10:
Annexin A10 Hs.188401 [show with all ESTs ] Unigene Representative Sequence: NM_007193 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000359299 (uc003irm.3 ) ENST00000507278 (uc003irn.3 ) ENST00000503003 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANXA10 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANXA10OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANXA10 (NM_007193 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANXA10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANXA10
Additional cDNA sequence: AF196478.1 AJ238979.1 AY626137.1 BC007320.2
3 DOTS entries : DT.75106697 DT.100638774
DT.95266257 24/64 AceView cDNA sequences (see all 64 ):
BM741409 CK823169 CK823168 BM126165 BM766503 BM126461 BQ100882 AI913045 BM766845 BM770895 BQ101189 NM_007193 CB163976 AY626137 BC007320 BM756894 BM770653 BG822888 AF196478 BG500743 CB163193 BM821041 BE789806 BU540688 GeneLoc Exon Structure
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Expression for ANXA10 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ANXA10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image ANXA10 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See ANXA10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ANXA10 SOURCE GeneReport for Unigene cluster: Hs.188401 SABiosciences Custom PCR Arrays for ANXA10 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANXA10Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ANXA10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANXA10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANXA10 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA10
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Orthologsfor ANXA10 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for ANXA10 gene from 5/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for ANXA10 (if available)TreeFam Gene Tree for ANXA10 (if available)
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Paralogsfor ANXA10 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ANXA10 gene ANXA3 2 ANXA6 2 ANXA1 2 ANXA5 2 ANXA9 2 ANXA2 2 ANXA7 2 ANXA8 2 ANXA11 2 ANXA8L2 2 ANXA8L1 2 ANXA4 2 ANXA13 2 14 SIMAP similar genes for ANXA10 using alignment to 1 protein entry: ANX10_HUMAN :ANXA3 ANXA11 ANXA5 ANXA6 ANXA8L1 ANXA4 ANXA8 ANXA8L2 ANXA7 ANXA13 ANXA1 ANXA2P2 ANXA9 ANXA2
ANXA10 for paralogs About GeneDecksing
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Genomic Variantsfor ANXA10 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for ANXA10 5 CNVs : 9010 6349 59183 2556 3526 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANXA10
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Disorders
/ Diseasesfor ANXA10 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ANXA10 for disorders About GeneDecksing
OMIM gene information: 608008
OMIM disorders : --13 diseases for ANXA10 : About MalaCards barrett's esophagus esophageal squamous cell carcinoma squamous cell carcinoma acute myeloid leukemia intrahepatic cholangiocarcinoma myeloid leukemia hepatocellular carcinoma cholangiocarcinoma esophagitis gastric cancer carcinoma leukemia adenocarcinoma 2 Novoseek disease relationships for ANXA10 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
hepatocellular carcinoma
24.6
2
12000734 (2)
tumors
1.51
3
12000734 (1), 15754002 (1), 17266044 (1)
Export disorders for ANXA10 gene to outside databases
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Publicationsfor ANXA10 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ANXA10 gene, integrated from 9 sources (see all 19 ): (articles sorted by number of sources associating them with ANXA10) Utopia : connect your pdf to the dynamic world of online information
Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution. (PubMed id 10458909) 1 , 2 , 3, 9 Morgan R.O.... Fernandez M.P. (1999) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Down-regulation of annexin A10 in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy with p53 mutation. (PubMed id 12000734) 1 , 9 Liu S.H....Hsu H.C. (2002) Reduced expression and homozygous deletion of annexin A10 in gastric carcinoma. (PubMed id 19582876) 1 , 9 Kim J....Kim W.H. (2009) Expression and prognostic significance of gastric-spe cific annexin A10 in diffuse- and intestinal-type gastric carcinoma. (PubMed id 21175800) 1 Lu S.H....Hsu H.C. (2011) Low ANXA10 expression is associated with disease aggr essiveness in bladder cancer. (PubMed id 21979422) 1 Munksgaard P.P....AgerbA (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Decreased expression of annexin A10 in gastric cancer and its overexpression in tumor cell growth suppression. (PubMed id 20664964) 1 Kim J.K....Nam S.W. (2010) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791) 1 Wang A.G....Kim N.S. (2006)
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External Searches for ANXA10 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ANXA10 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ANXA10 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ANXA10 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ANXA10 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ANXA10 gene: Search GeneIP for patents involving ANXA10 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ANXA10 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for ANXA10 OriGene shRNA RFP for ANXA10 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ANXA10 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANXA10 OriGene Protein Over-expression Lysate for ANXA10 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ANXA10 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANXA10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANXA10 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ANXA10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ANXA10 OriGene Custom Protein Services for ANXA10 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANXA10 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANXA10 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA10 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ANXA10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANXA10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANXA10
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA10
ThermoFisher Antibodies for ANXA10
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANXA10
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