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Aliases for ANXA10 Gene

Aliases for ANXA10 Gene

  • Annexin A10 2 3
  • Annexin-10 3 4
  • Annexin-14 3 4
  • ANX14 3 4
  • Annexin 14 3

External Ids for ANXA10 Gene

Previous GeneCards Identifiers for ANXA10 Gene

  • GC04P169783
  • GC04P169435
  • GC04P169598
  • GC04P169709
  • GC04P169388
  • GC04P169250
  • GC04P169013
  • GC04P164764

Summaries for ANXA10 Gene

Entrez Gene Summary for ANXA10 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA10 Gene

ANXA10 (Annexin A10) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA9.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA10 Gene

Genomics for ANXA10 Gene

Regulatory Elements for ANXA10 Gene

Genomic Location for ANXA10 Gene

Start:
168,081,299 bp from pter
End:
168,187,742 bp from pter
Size:
106,444 bases
Orientation:
Plus strand

Genomic View for ANXA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANXA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA10 Gene

Proteins for ANXA10 Gene

  • Protein details for ANXA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ72-ANX10_HUMAN
    Recommended name:
    Annexin A10
    Protein Accession:
    Q9UJ72
    Secondary Accessions:
    • Q96IQ5
    • Q9UJV4

    Protein attributes for ANXA10 Gene

    Size:
    324 amino acids
    Molecular mass:
    37278 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANXA10 Gene

Proteomics data for ANXA10 Gene at MOPED

Post-translational modifications for ANXA10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ANXA10 Gene

Domains for ANXA10 Gene

Gene Families for ANXA10 Gene

HGNC:

Protein Domains for ANXA10 Gene

Suggested Antigen Peptide Sequences for ANXA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJ72

UniProtKB/Swiss-Prot:

ANX10_HUMAN :
  • Q9UJ72
Family:
  • Belongs to the annexin family.
Similarity:
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA10: view

Function for ANXA10 Gene

Molecular function for ANXA10 Gene

GENATLAS Biochemistry:
annexin A10,progenitor of annexin A6 octad formation via chromosome duplication during early chordate evolution

Gene Ontology (GO) - Molecular Function for ANXA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0005544 calcium-dependent phospholipid binding IEA --
genes like me logo Genes that share ontologies with ANXA10: view

Phenotypes for ANXA10 Gene

GenomeRNAi human phenotypes for ANXA10:
genes like me logo Genes that share phenotypes with ANXA10: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANXA10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ANXA10 Gene

Localization for ANXA10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA10 Gene COMPARTMENTS Subcellular localization image for ANXA10 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ANXA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ANXA10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA10 Gene

Pathways for ANXA10 Gene

SuperPathways for ANXA10 Gene

No Data Available

Interacting Proteins for ANXA10 Gene

Gene Ontology (GO) - Biological Process for ANXA10 Gene

None

No data available for Pathways by source for ANXA10 Gene

Transcripts for ANXA10 Gene

Unigene Clusters for ANXA10 Gene

Annexin A10:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANXA10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA10 Gene

No ASD Table

Relevant External Links for ANXA10 Gene

GeneLoc Exon Structure for
ANXA10
ECgene alternative splicing isoforms for
ANXA10

Expression for ANXA10 Gene

mRNA expression in normal human tissues for ANXA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA10 Gene

This gene is overexpressed in Stomach (39.7) and Liver (7.1).

Protein differential expression in normal tissues for ANXA10 Gene

This gene is overexpressed in Cardia (30.3) and Stomach (22.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANXA10 Gene

SOURCE GeneReport for Unigene cluster for ANXA10 Gene Hs.188401

genes like me logo Genes that share expressions with ANXA10: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for ANXA10 Gene

Orthologs for ANXA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANXA10 35
  • 84.88 (n)
  • 86.11 (a)
ANXA10 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA10 35
  • 88.16 (n)
  • 90.88 (a)
ANXA10 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa10 35
  • 87.45 (n)
  • 88.89 (a)
Anxa10 16
Anxa10 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANXA10 35
  • 99.28 (n)
  • 98.46 (a)
ANXA10 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa10 35
  • 85.91 (n)
  • 87.35 (a)
oppossum
(Monodelphis domestica)
Mammalia ANXA10 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANXA10 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANXA10 35
  • 79.42 (n)
  • 82.1 (a)
ANXA10 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa10 35
  • 74.59 (n)
  • 76.85 (a)
zebrafish
(Danio rerio)
Actinopterygii anxa13 36
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nex-1 36
  • 35 (a)
ManyToMany
nex-3 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7864 36
  • 13 (a)
ManyToMany
Species with no ortholog for ANXA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA10 Gene

ENSEMBL:
Gene Tree for ANXA10 (if available)
TreeFam:
Gene Tree for ANXA10 (if available)

Paralogs for ANXA10 Gene

Paralogs for ANXA10 Gene

Selected SIMAP similar genes for ANXA10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANXA10: view

Variants for ANXA10 Gene

Sequence variations from dbSNP and Humsavar for ANXA10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs477897 -- 168,177,763(-) GGGTC(C/T)GTATA reference, synonymous-codon
rs492883 -- 168,183,828(-) TCATA(A/T)TTTGA intron-variant
rs515357 -- 168,186,458(+) TTAGG(A/T)CATGA intron-variant
rs517108 -- 168,186,291(+) GAAGA(C/T)CATTA intron-variant
rs547190 -- 168,185,342(-) AAGTA(A/G)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA10 Gene

Variant ID Type Subtype PubMed ID
nsv428455 CNV Gain 18775914
dgv1714e1 CNV Complex 17122850
dgv1715e1 CNV Complex 17122850
dgv194e55 CNV Loss 17911159
nsv881050 CNV Loss 21882294
nsv830146 CNV Gain 17160897
dgv5823n71 CNV Loss 21882294
nsv881291 CNV Gain 21882294
nsv881391 CNV Loss 21882294
nsv820236 CNV Gain 19587683
nsv822825 CNV Gain 20364138
nsv521908 CNV Loss 19592680
nsv293790 CNV Loss 16902084

Relevant External Links for ANXA10 Gene

HapMap Linkage Disequilibrium report
ANXA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA10 Gene

Disorders for ANXA10 Gene

(2) Novoseek inferred disease relationships for ANXA10 Gene

Disease -log(P) Hits PubMed IDs
hepatocellular carcinoma 24.6 2
tumors 1.51 3
genes like me logo Genes that share disorders with ANXA10: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for ANXA10 Gene

Publications for ANXA10 Gene

  1. Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution. (PMID: 10458909) Morgan R.O. … Fernandez M.-P. (Genomics 1999) 2 3 4 23
  2. Down-regulation of annexin A10 in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy with p53 mutation. (PMID: 12000734) Liu S.H. … Hsu H.C. (Am. J. Pathol. 2002) 3 23
  3. Reduced expression and homozygous deletion of annexin A10 in gastric carcinoma. (PMID: 19582876) Kim J. … Kim W.H. (Int. J. Cancer 2009) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for ANXA10 Gene

Sources for ANXA10 Gene

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