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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANXA1 Gene

protein-coding   GIFtS: 71
GCID: GC09P075766

annexin A1


(Previous symbols: ANX1, LPC1)
 Explore 74 diseases affiliated with
ANXA1 via our new
 Human Malady Compendium 
Biological research products
for ANXA1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Annexin A11 2     Annexin-13
LPC11 2 3 5     Calpactin-23
ANX11 2 3     Chromobindin-93
Calpactin II2 3     Annexin-13
Lipocortin I2 3     Calpactin-23
Phospholipase A2 Inhibitory Protein2 3     Chromobindin-93
P351     Annexin I3
Annexin I (Lipocortin I)2     

External Ids:    HGNC: 5331   Entrez Gene: 3012   Ensembl: ENSG000001350467   OMIM: 1516905   UniProtKB: P040833   

Export aliases for ANXA1 gene to outside databases

Previous GC identifers: GC09P066811 GC09P067623 GC09P069336 GC09P071223 GC09P072996 GC09P074956 GC09P045589


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANXA1:
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of
approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I
protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since
phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and
leukotrienes, annexin I may have potential anti-inflammatory activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Gene Wiki entry for ANXA1 (Annexin A1)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANXA1 gene promoter:
         C/EBPbeta   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   AREB6   POU2F1   POU2F1a   STAT3   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ANXA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANXA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q21.13

ANXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P075766:  view genomic region     (about GC identifiers)

Start:
75,766,673 bp from pter      End:
75,785,309 bp from pter
Size:
18,637 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083 (See protein sequence)
Recommended Name: Annexin A1  
Size: 346 amino acids; 38714 Da
Subunit: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity).
Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated
cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar
macrophages (By similarity)
3 PDB 3D structures from and Proteopedia for ANXA1:
1AIN (3D)        1BO9 (3D)        1QLS (3D)    

Explore the universe of human proteins at neXtProt for ANXA1: NX_P04083

Post-translational modifications:

  • Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss
  • of the inhibitory activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P04083

  • ANXA1 Protein expression data from MOPED and PaxDb:    About this image 
    ANXA1 Protein Expression
    REFSEQ proteins: NP_000691.1  
    ENSEMBL proteins: 
     ENSP00000257497   ENSP00000412489   ENSP00000414013   ENSP00000366109  
    Reactome Protein details: P04083
    Human Recombinant Protein Products for ANXA1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Uscn Proteins for ANXA1

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001533cornified envelope IDA10908733
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005625soluble fraction ----
    GO:0005634nucleus IEA--

    ANXA1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ANXA1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR002388 AnnexinI
     IPR018502 Annexin_repeat

    Graphical View of Domain Structure for InterPro Entry P04083

    ProtoNet protein and cluster: P04083

    2 Blocks protein families:
    IPB001464 Annexin
    IPB002388 Annexin type I signature


    UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANXA1_HUMAN, P04083
    Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
    protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

         Genatlas biochemistry entry for ANXA1:
    annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of the
    organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid feadback
    action in the hypothalamo-hypophysial system

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003697single-stranded DNA binding ----
    GO:0003727single-stranded RNA binding ----
    GO:0004859phospholipase inhibitor activity ----
    GO:0005102receptor binding TAS10882119
    GO:0005198structural molecule activity IDA10908733
         
    ANXA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ANXA1:
     Decreased viability 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Anxa1):
     adipose tissue  cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     skeleton  tumorigenesis 

    ANXA1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ANXA1 

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)1.00
    Peptide ligand-binding receptors0.61
    GPCR ligand binding0.75
    G alpha (i) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR1.00
    Signal Transduction0.56
    GPCR downstream signaling0.89
    3G alpha (q) signalling events
    G alpha (q) signalling events1.00
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    4Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway1.00
    Integrated Pancreatic Cancer Pathway0.99
    5Ca, cAMP and Lipid Signaling
    Ca, cAMP and Lipid Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for ANXA1
        Selected targets of CREB1
    Selected targets of C/EBPalpha


    1 Cell Signaling Technology (CST) Pathway for ANXA1
        Ca, cAMP and Lipid Signaling

    4 BioSystems Pathways for ANXA1 
        Integrated Breast Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    Prostaglandin Synthesis and Regulation

    5/10        Reactome Pathways for ANXA1 (see all 10)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    ANXA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANXA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/309 Interacting proteins for ANXA1 (P040831, 2, 3 ENSP000002574974) via UniProtKB, MINT, STRING, and/or I2D (see all 309)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBB1O002132, 3, ENSP000002994024MINT-8247707 I2D: score=2 STRING: ENSP00000299402
    C14orf1Q9UKR52, 3MINT-8247720 I2D: score=2 
    CCT7Q998322, 3MINT-8247753 I2D: score=2 
    COPS6Q7L5N12, 3MINT-8247764 I2D: score=2 
    CSADQ9Y6002, 3MINT-8247775 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001776leukocyte homeostasis ----
    GO:0001780neutrophil homeostasis IMP--
    GO:0002674negative regulation of acute inflammatory response IEA--
    GO:0006928cellular component movement TAS10882119
    GO:0006954inflammatory response TAS10882119

    ANXA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANXA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ANXA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Ac9-25Annexin I N-terminal peptide. Acts as a FPR1 ligand[284040-76-2]
    Ac2-26Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation[151988-33-9]
    Ac2-12Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation[256447-08-2]

    1 HMDB Compound for ANXA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for ANXA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Hydrocortisone11beta-Hydroxycortisone (see all 16)50-23-7targetagonist1712816 17139284 11142771 17016423 8060156
    DexamethasoneDesametasone (see all 9)50-02-2targetagonist17644190 17076770 17158208 16883066
    Amcinonide-- 51022-69-6targetagonist17139284 17016423 7981624

    10/56 Novoseek chemical compound relationships for ANXA1 gene (see all 56)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hdmnkvldl 84.9 2 8818992 (1), 1793057 (1)
    phosphatidylserine 62.1 29 8179621 (3), 7627125 (1), 12744815 (1), 15381697 (1) (see all 16)
    phospholipid 59.7 33 8379935 (7), 2138536 (1), 1310621 (1), 8485141 (1) (see all 20)
    calcium 55 126 11142771 (6), 9299392 (5), 18283055 (4), 1469069 (3) (see all 58)
    arachidonic acid 49.2 16 2064175 (2), 8260938 (2), 2137129 (2), 12845669 (1) (see all 10)
    dexamethasone 45.3 54 8256657 (6), 12236584 (5), 17644190 (4), 14668092 (3) (see all 17)
    glyceraldehyde 3-phosphate 44.7 7 16220529 (1), 17268060 (1), 15274135 (1), 19899082 (1) (see all 7)
    geneticin 32.2 1 7764687 (1)
    phosphatidylcholine 30.4 17 16307464 (2), 12845669 (1), 7654693 (1), 1387325 (1) (see all 5)
    p-opc 30 7 16307464 (3), 18237543 (2)

    Search CenterWatch for drugs/clinical trials and news about ANXA1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANXA1 gene: 
    NM_000700.1  

    Unigene Cluster for ANXA1:

    Annexin A1
    Hs.494173  [show with all ESTs]
    Unigene Representative Sequence: AK074480
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257497(uc004ajf.1) ENST00000456643 ENST00000468639 ENST00000415424
    ENST00000376911(uc004ajg.1) ENST00000495713 ENST00000489109 ENST00000491192


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    Additional cDNA sequence: 

    AB451274.1 AB451401.1 AK023330.1 AK074480.1 AK296808.1 AK311684.1 BC001275.1 BC018683.1 
    BC034157.1 BC035993.1 BT019896.1 BT019916.1 BT019917.1 CR407684.1 X05908.1 

    24/49 DOTS entries (see all 49):

    DT.95080391  DT.100890399  DT.95202652  DT.100765659  DT.100890413  DT.100890422  DT.100890394  DT.100890395 
    DT.121161786  DT.100890415  DT.95340497  DT.95223581  DT.92045136  DT.92466092  DT.100040129  DT.100890410 
    DT.100890409  DT.91793108  DT.91703452  DT.91949347  DT.121161854  DT.100890404  DT.92466082  DT.92466099 

    24/1569 AceView cDNA sequences (see all 1569):

    BQ434247 CB132717 CB136230 CB110563 BM987259 BQ775882 AL702872 BG760604 
    CB134061 CA418081 BE885625 BM762806 BP368115 BU615234 BM970156 BU182629 
    CB161300 CB155823 CA441775 AI962890 AK074480 AU138337 BQ776007 BM981135 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:              -     -     -     -     -                 -           -                 -                             -                 -                     
    SP2:                                                        -           -                 -                             -                 -                     
    SP3:              -           -     -     -                 -           -                 -                             -                                       
    SP4:                                                                                      -                             -                                       
    SP5:                    -     -     -     -                 -           -                 -                                                                     


    ECgene alternative splicing isoforms for ANXA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANXA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAAAGATGT
    ANXA1 Expression
    About this image

    ANXA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartMyocardiumCardiac FibroblastsEpicardium
    KidneyPodocyte LayerPodocytesKidney
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    AdiposeVisceral White AdiposeAdipose
    BrainMedulla OblongataBrain
    KidneyRenal Collecting Duct SystemKidney
    LungTracheaLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Dorsal forebrain-like neurons (Generation of midbra...)Brain
    N2/LSB induced-cells (Generation of midbra...)
    Syncytiotrophoblast-like cells (Generation of syncyt...)

    See ANXA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANXA1

    SOURCE GeneReport for Unigene cluster: Hs.494173
        SABiosciences Expression via Pathway-Focused PCR Array including ANXA1: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANXA1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANXA1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANXA1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANXA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANXA1 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ANXA11 annexin A1 75.07(n)
    78.59(a)
      404271  NM_206906.1  NP_996789.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA16
    --
    76(a)
    1 ↔ 1
    2(47805415-47820443)
    African clawed frog
    (Xenopus laevis)
    Amphibia anxa1-prov2 annexin A1 77.96(n)    BC053786.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anxa1a2 annexin A1a 73.36(n)   334724  AY178793.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AnnIX3 actin binding 45(a)   93B10   --
    worm
    (Caenorhabditis elegans)
    Secernentea nex-23 Annexin 42(a)
    (best of 3)
      III(10397630-10399688)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ANNAT26
    ANNAT56
    (see all 8)
    annexin D5
    (see all 8)
    33(a)
    32(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    5(25973815-25975726)
    1(25519442-25520774)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 9)
    annexin, putative, expressed
    (see all 9)
    36(a)
    32(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    9(13705487-13710510)
    8(20456985-20458908)


    ENSEMBL Gene Tree for ANXA1 (if available)
    TreeFam Gene Tree for ANXA1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANXA1 gene
    ANXA32  ANXA62  ANXA52  ANXA92  ANXA22  ANXA72  ANXA82  ANXA112  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA1 using alignment to 6 protein entries:     ANXA1_HUMAN (see all proteins):
    ANXA2    ANXA2P2    DKFZp686H02120    ANXA13    ANXA7    ANXA8
    ANXA11    ANXA3    ANXA4    ANXA5    ANXA8L2    ANXA6
    ANXA8L1    ANXA9    ANXA10

    ANXA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    331/367 NCBI SNPs in ANXA1 are shown (see all 367    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127652951,2
    C,F--75764783(+) TAGTGG/ACTTTC 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs23103121,2
    C,F,O,A,H--75764998(+) CAAAGC/AAAAAT 1 -- us2k124Minor allele frequency- A:0.19NA NS EA WA 2694
    rs1390908591,2
    --75765039(+) TTTTAC/TAAAAA 1 -- us2k10--------
    rs1423959281,2
    --75765093(+) AGGAAA/TGTTCC 1 -- us2k10--------
    rs37583551,2
    C,H--75765100(+) TTCCAA/GTAGTT 1 -- us2k15Minor allele frequency- G:0.02EA NS 1898
    rs1929154221,2
    --75765212(+) TATTAA/GAAAGT 1 -- us2k10--------
    rs785905931,2
    C--75765229(+) ACATCT/CGTCAA 1 -- us2k13Minor allele frequency- C:0.08CSA WA 121
    rs1851810361,2
    --75765234(+) TGTCAA/GGATCA 1 -- us2k10--------
    rs339429881,2
    C--75765264(+) ACTTA-/ACTTGT 1 -- us2k10--------
    rs1170381621,2
    F--75765351(+) GATTAG/CATGAT 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1486260531,2
    --75765359(+) GATCAC/TCCTAC 1 -- us2k10--------
    rs27951081,2
    C,F,O,A,H--75765478(+) TTTTAT/CGTGAA 1 -- us2k121Minor allele frequency- C:0.25NA NS EA WA 2478
    rs101215851,2
    C,F,H--75765509(+) AAAAAG/TAACAA 1 -- us2k1 trp38Minor allele frequency- T:0.11NS EA WA NA 778
    rs1421246821,2
    --75765563(+) TTACAA/CCTGTG 1 -- us2k10--------
    rs1896473811,2
    --75765658(+) TTTCCA/TCCATT 1 -- us2k10--------
    rs1510803621,2
    --75765728(+) ATTTTA/GTAGGT 1 -- us2k10--------
    rs1916186641,2
    --75765785(+) TGTATC/TAAAAT 1 -- us2k10--------
    rs760027931,2
    --75765972(+) CTTCTA/GTATTT 1 -- us2k12Minor allele frequency- G:0.05CSA NA 122
    rs1126162851,2
    F--75766141(+) TAGATG/AATGCT 1 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs770261811,2
    C,F--75766144(+) ATAATG/ACTCCT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs756952651,2
    F--75766169(+) AAACAG/ACTAGG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1120377491,2
    --75766271(+) ATAACG/AAGACC 1 -- us2k12Minor allele frequency- A:0.08CSA WA 120
    rs27951091,2
    F--75766409(+) TGTTTG/TTTGGT 1 -- us2k1 tfbs31Minor allele frequency- T:0.05WA 118
    rs27951101,2
    C,F,A,H--75766412(+) TTGTTG/TGTTTG 1 -- us2k19Minor allele frequency- T:0.29NA WA EA 370
    rs1449044101,2
    --75766432(+) GAAGGC/TAACAT 1 -- us2k10--------
    rs1837295371,2
    --75766446(+) TTTTAG/TTCTAC 1 -- us2k10--------
    rs1171531351,2
    --75766500(+) TTGGGG/ACAGAT 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1881459911,2
    --75766637(+) GAGTAA/GTTTTG 1 -- us2k10--------
    rs1479686421,2
    --75766751(+) ATCCTA/GTAAAA 1 -- us2k10--------
    rs1820071661,2
    --75766832(+) AGGTAC/GAGATA 1 -- ut510--------
    rs37399561,2
    C,F,H--75766838(+) AGATAA/GAGGTA 1 -- ut5114Minor allele frequency- G:0.16EA NA NS WA 2196
    rs783307921,2
    F--75766875(+) TTGGTT/GGTTTT 1 -- int11Minor allele frequency- G:0.13WA 118
    rs1872115711,2
    --75766957(+) ATAAGA/TCATTC 1 -- int10--------
    rs1175200901,2
    F--75767067(+) GATAAG/ATTTGC 1 -- int11Minor allele frequency- A:0.04EA 120
    rs795516651,2
    --75767157(+) AAGAAC/TGTGTT 1 -- int10--------
    rs1904458871,2
    --75767177(+) CTTCCC/TCTTGA 1 -- int10--------
    rs1818068111,2
    --75767200(+) CAAGAA/GCTGTG 1 -- int10--------
    rs767798271,2
    F--75767240(+) GCTTTT/CTGGGG 1 -- int11Minor allele frequency- C:0.14WA 118
    rs1470251781,2
    --75767276(+) GCTGCA/CGGGAA 1 -- int10--------
    rs1452075061,2
    --75767415(+) TTATGC/TTATTT 1 -- int10--------
    rs1491563481,2
    --75767435(+) AGGTCC/TGCTTA 1 -- int10--------
    rs759021961,2
    --75767585(+) AGGGGA/TATGTC 1 -- int13Minor allele frequency- T:0.08CSA WA 121
    rs1124662731,2
    --75767695(+) ACTAGC/TGTTGG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1868297831,2
    --75767952(+) AATGCA/TCATTG 1 -- int10--------
    rs1482416481,2
    --75768023(+) AAGTGA/GCAGTA 1 -- int10--------
    rs1118391681,2
    --75768037(+) CCCTAG/CCTCCA 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs1903714471,2
    --75768064(+) GCACAC/TAGCCA 1 -- int10--------
    rs27951111,2
    C,F--75768078(+) TTTAAC/AAGATG 1 -- int11Minor allele frequency- A:0.05WA 118
    rs1455517461,2
    --75768083(+) CAGATA/GTTGAC 1 -- int10--------
    rs108692291,2
    C,F,A,H--75768094(+) AAAATA/GGTTAA 1 -- int19Minor allele frequency- G:0.23NS EA NA 538
    rs604032321,2
    C--75768163(+) AGAAGG/CTCTGC 1 -- int11Minor allele frequency- C:0.50WA 2
    rs43015021,2
    C,F,A,H--75768183(+) TTTCTG/AAATAT 1 -- int115Minor allele frequency- A:0.09NS EA NA WA 1410
    rs1147241441,2
    C,F--75768209(+) TAGACC/TTATTA 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1112454121,2
    --75768334(+) TTCATC/TAGGAA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1505017901,2
    --75768379(+) TCATTA/GTGCTA 1 -- int10--------
    rs1383893881,2
    --75768437(+) TCAGAA/GCTGTA 1 -- int10--------
    rs1825861611,2
    --75768488(+) ATAAAC/TGAAGA 1 -- int10--------
    rs750719481,2
    F--75768836(+) TGAAGT/GCAGGA 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1163624201,2
    C,F--75769008(+) AAGAAC/AACCCT 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1492670961,2
    --75769210(+) TGAAAA/CCTGCT 1 -- int10--------
    rs1445101631,2
    --75769224(+) GTCTGC/TGCAAG 1 -- int10--------
    rs1409145761,2
    --75769225(+) TCTGCA/GCAAGT 1 -- int10--------
    rs454989991,2
    C,F--75769299(+) CTTTTT/CGGTCA 1 -- int12Minor allele frequency- C:0.02NA EU 689
    rs1854903421,2
    --75769390(+) TATGTC/TGCCCA 1 -- int10--------
    rs122385071,2
    --75769485(+) GAGTAG/TATGGG 1 -- int10--------
    rs1898933801,2
    --75769812(+) CATTGC/TTGTTA 1 -- int10--------
    rs117909431,2
    C,H--75769843(+) TAGTTC/TTAGAT 1 -- int14Minor allele frequency- T:0.00NS EA 418
    rs1475121471,2
    --75769891(+) TTCCTC/GTGTCA 1 -- int10--------
    rs605219531,2
    F--75769917(+) GGTAGC/ACTTTC 1 -- int11Minor allele frequency- A:0.08EA 120
    rs27951121,2
    C,F,A,H--75769950(+) TGAAGC/GGGGGG 1 -- int115Minor allele frequency- G:0.24NS EA NA WA 1204
    rs1826323931,2
    --75770067(+) AAGACC/TATTAA 1 -- int10--------
    rs122385621,2
    H--75770076(+) AATTAG/AAAGAA 1 -- int14Minor allele frequency- A:0.00NS EA 420
    rs27951131,2
    C,F,O,A,H--75770132(+) TGGCCA/TATTTC 1 -- int132Minor allele frequency- T:0.13EA NA NS WA 3396
    rs786263391,2
    --75770178(+) CTTAGT/CTTTAG 1 -- int12Minor allele frequency- C:0.07CSA WA 119
    rs1888749561,2
    --75770270(+) GCAAGA/CTTTAT 1 -- int10--------
    rs1401387261,2
    --75770485(+) GCCCTG/TAACCA 1 -- int10--------
    rs133018701,2
    H--75770605(+) ATTCCG/CTTTTT 1 -- int14Minor allele frequency- C:0.00NS EA 418
    rs1932199171,2
    --75770609(+) CGTTTC/TTCTCT 1 -- int10--------
    rs1151990481,2
    F--75770683(+) TATCCA/GAATAC 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1470628961,2
    C--75770774(+) GACTT-/AAAC  
            
    AACTT
    1 -- int10--------
    rs1835798341,2
    --75770869(+) AGTATG/TTTTTA 1 -- int10--------
    rs357286111,2
    C--75770879(+) GAAGT-/AAAAAA 1 -- int10--------
    rs123446701,2
    C,F,H--75770912(+) TATAAC/TGTTTA 1 -- int110Minor allele frequency- T:0.10NS EA NA WA 914
    rs1872977101,2
    --75770999(+) TTTTAA/TTTGCT 1 -- int10--------
    rs111435091,2
    F,H--75771013(+) TGAAAA/GGAATG 1 -- int15Minor allele frequency- G:0.08NS EA NA 540
    rs2000054481,2
    --75771034(+) ATAAT-/AAATAA 1 -- int10--------
    rs1396746611,2
    C--75771035(+) ATAAT-/AAATAA 1 -- int10--------
    rs2011981131,2
    --75771037(+) AATAA-/TAATAA 1 -- int10--------
    rs671118421,2
    C--75771038(+) AATAAA/-TAAAT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1995456931,2
    --75771067(+) AATAT-/AAATAAA 1 -- int10--------
    rs108692301,2
    A--75771068(+) atataA/Tataaa 1 -- int10--------
    rs798086921,2
    F--75771270(+) CAATTA/TAGAAG 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1429840921,2
    --75771304(+) CAACCA/GCAATT 1 -- int10--------
    rs27951141,2
    C,F,O,A,H--75771314(+) TGCATG/CAAACT 1 -- int141Minor allele frequency- C:0.39EA NA NS WA CSA 5252
    rs1839475361,2
    --75771356(+) AATTGC/TGGGTT 1 -- int10--------
    rs770195051,2
    F--75771456(+) CACAGA/GTGACA 1 -- int11Minor allele frequency- G:0.10EA 120
    rs1883834191,2
    --75771474(+) AATAAA/GAGCAA 1 -- int10--------
    rs170585511,2
    C,F,H--75771557(+) GCAACT/CCCAGT 1 -- int18Minor allele frequency- C:0.01NA EA NS 486
    rs47452181,2
    C,F,A,H--75771935(+) GATAGC/TAATTC 1 -- int122Minor allele frequency- T:0.08NS EA NA WA 2766
    rs1912918371,2
    --75772064(+) TGTTGC/GGTGGG 1 -- int10--------
    rs776228571,2
    C--75772072(+) GGGAAA/GATATG 1 -- int13Minor allele frequency- G:0.07CSA WA 121
    rs1843437351,2
    --75772103(+) CTCAAA/TTAGGA 1 -- int10--------
    rs1409529721,2
    --75772218(+) TACAAC/TTAAAA 1 -- int10--------
    rs790623041,2
    C--75772274(+) CCTTAT/CAAATG 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1497984141,2
    --75772298(+) GGAGTA/GGTAGC 1 -- int10--------
    rs1457825101,2
    --75772336(+) AGGCCA/GAGGCG 1 -- int10--------
    rs1406157781,2
    --75772381(+) CCTAGA/CCAACA 1 -- int10--------
    rs1470168341,2
    --75772395(+) TGAAAA/TCCTGT 1 -- int10--------
    rs1904387171,2
    --75772506(+) CGGAGG/TTTGCA 1 -- int10--------
    rs1823126611,2
    --75772548(+) CTGGGC/TGACAG 1 -- int10--------
    rs1868735071,2
    --75772611(+) TTTCAG/TCTAGC 1 -- int10--------
    rs176526101,2
    C--75772639(+) CTCTCA/GTTAAT 1 -- int1 ese33Minor allele frequency- G:0.01NA 142
    rs1410771531,2
    --75772697(+) ATCTTA/GTCTAT 1 -- int10--------
    rs27951151,2
    F,H--75772797(+) GAAACC/TCATTA 1 -- int15Minor allele frequency- T:0.03NS EA WA 538
    rs360295211,2
    C,F--75772828(+) GGACAC/TATTGA 1 -- int13Minor allele frequency- T:0.33NA 6
    rs1136056411,2
    C--75772836(+) TGAAGC/TTTCTT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs734916391,2
    C--75772842(+) TTCTTG/CTTTCA 1 -- int11Minor allele frequency- C:0.50WA 2
    rs1432028661,2
    --75772867(+) TTCTCA/GCTCCA 1 -- int10--------
    rs28112221,2
    C,F,H--75772921(+) AACTTT/CTCTGC 1 -- int1 ese35Minor allele frequency- C:0.03NS EA WA 538
    rs123790091,2
    C,F,H--75773029(+) ACTAGC/GTTTAA 1 -- int111Minor allele frequency- G:0.02NS EA NA 688
    rs287201051,2
    C--75773097(+) ATGGTG/AGGTGG 1 -- int13Minor allele frequency- A:0.13WA NA 122
    rs27951161,2
    C,F,O,A,H--75773161(+) TGCTTA/GCTTGT 1 -- int1 ese322Minor allele frequency- G:0.17NA NS EA WA 2486
    rs2021585671,2
    --75773403(+) GCATTA/TGTTTT 1 -- int10--------
    rs1857235001,2
    C--75773415(+) TAAAAA/GCATCT 1 -- int10--------
    rs2010415411,2
    --75773527(+) GTAGAA/GTGATA 1 -- int10--------
    rs1485321111,2
    C--75773610(+) TCTTAG/ACAAAC 1 -- spa11Minor allele frequency- A:0.00NA 4536
    rs2005004501,2
    --75773640(+) GGTCCC/TGGATC 2 P syn10--------
    rs1997727081,2
    --75773643(+) CCCGGA/CTCAGC 2 G syn10--------
    rs353047641,2
    C,F--75773649(+) TCAGCA/G/TGTGAG 3 A syn12NA 4624
    rs115570521,2
    H--75773671(+) CCTTCA/GATCCA 2 N D mis1 ese34Minor allele frequency- G:0.00NS EA 406
    rs1481877211,2
    C--75773682(+) TCCTCA/GGATGT 2 S syn10--------
    rs1411752211,2
    C--75773707(+) AGGCCA/TTAATG 2 I L mis10--------
    rs1901433591,2
    C--75773754(+) CTGGAC/TATTTC 1 -- int10--------
    rs28112231,2
    F,H--75773842(+) ATTTCT/CTTGCC 1 -- int15Minor allele frequency- C:0.03NS EA WA 538
    rs749318911,2
    --75773886(+) GAAATT/CGTGTT 1 -- int11Minor allele frequency- C:0.01EA 120
    rs785732821,2
    F--75773944(+) TCTAGC/AAGAAA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1507418311,2
    --75773961(+) GCTGAA/GATTAA 1 -- int10--------
    rs123485351,2
    C,F,H--75774052(+) TTTCTC/TACTCG 1 -- int1 trp312Minor allele frequency- T:0.07NS EA NA WA 1310
    rs1379668161,2
    --75774151(+) GTTAAG/TAAGTT 1 -- int10--------
    rs752971271,2
    C,F--75774216(+) TTGGTG/ATTAAA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs101143501,2
    C,F,H--75774238(+) CTTTAT/CTTCCA 1 -- int14Minor allele frequency- C:0.01NS EA 420
    rs764591321,2
    C--75774283(+) CTAAGC/TGAAAC 2 R * stg10--------
    rs1160801951,2
    C,F--75774306(+) CAACAG/CATCAA 2 /H /Q mis12Minor allele frequency- C:0.00WA NA 4668
    rs1826421211,2
    C--75774348(+) AGTTAA/GAGTGG 1 -- int10--------
    rs1860224901,2
    --75774481(+) TTTATC/GCACTT 1 -- int10--------
    rs120008401,2
    C,F,H--75774574(+) TCTGGG/TGACAA 1 -- int117Minor allele frequency- T:0.05NS EA NA WA 2326
    rs1920544441,2
    --75774771(+) ACTATA/GTAATT 1 -- int10--------
    rs1840412041,2
    --75774834(+) GGAAAA/CATGAA 1 -- int10--------
    rs1475008901,2
    --75775083(+) TAGGGA/TTGAGT 1 -- int10--------
    rs175744381,2
    C,F,H--75775116(+) TAATAT/CCACAT 1 -- int17Minor allele frequency- C:0.00NA NS EA 562
    rs10503051,2
    C,F,H--75775235(+) GTTTTA/GGCTCT 2 L syn121Minor allele frequency- G:0.14NS EA NA WA EU 8206
    rs1141698351,2
    C,F--75775331(+) CAAGAG/AGATGT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1875165951,2
    C--75775338(+) ATGTAC/TTGGGC 1 -- int10--------
    rs2019279571,2
    --75775339(+) TGTATA/TGGGCA 1 -- int10--------
    rs101196541,2
    C,F,H--75775483(+) ACCTTC/TCATGT 1 -- int16Minor allele frequency- T:0.06NS EA WA 540
    rs1905307971,2
    --75775562(+) TGTTTG/TAGGGC 1 -- int10--------
    rs781001871,2
    --75775597(+) ATTAAA/GTGTTG 1 -- int10--------
    rs1827197211,2
    --75775624(+) AATGAC/TAGAGT 1 -- int10--------
    rs1870898061,2
    --75775630(+) AGAGTC/GAAACA 1 -- int10--------
    rs1928445471,2
    --75775672(+) CTTGCA/TTGAAG 1 -- int10--------
    rs2009904831,2
    --75775813(+) GGGTAA/GGTTGT 1 -- int10--------
    rs2001436101,2
    --75775837(+) CCAAAC/TGCCTT 1 -- int10--------
    rs1844772921,2
    --75775888(+) GTCTAC/TGGTAA 1 -- int10--------
    rs38372991,2
    C--75776181(+) TTTTT-/TGAAAA 1 -- int10--------
    rs1877708101,2
    --75776219(+) ATCTCC/TTAACA 1 -- int10--------
    rs70318461,2
    C,F,H--75776300(+) TTTATC/TGTTAT 1 -- int16Minor allele frequency- T:0.06NS EA CSA WA 535
    rs1931468181,2
    --75776387(+) GTGAAA/GCATCT 1 -- int10--------
    rs1444164561,2
    --75776540(+) CATACC/GAAGCA 1 -- int10--------
    rs105214511,2
    C,F,H--75776652(+) TTACCA/CATGTT 1 -- int117Minor allele frequency- C:0.08NS NA EA WA 898
    rs1848712161,2
    --75776658(+) ATGTTC/TATGTT 1 -- int10--------
    rs1892889041,2
    --75776662(+) TTATGC/TTAGAT 1 -- int10--------
    rs27951171,2
    C,F,O,A,H--75776681(+) CAGTGA/GTAATA 1 -- int116Minor allele frequency- G:0.44NS EA NA WA 928
    rs1487148161,2
    --75776719(+) ATAGTG/TTATAA 1 -- int10--------
    rs1816780001,2
    --75776732(+) ATAAGC/TGTTTA 1 -- int10--------
    rs1844127701,2
    --75776808(+) TTTTAA/GTCCGT 1 -- int10--------
    rs1888126331,2
    --75776812(+) AGTCCA/GTTTGT 1 -- int10--------
    rs1422520741,2
    --75776869(+) AAATAC/TTGTAC 1 -- int10--------
    rs1812192141,2
    --75777086(+) ATCTCA/CCAACA 1 -- int10--------
    rs1467884581,2
    --75777250(+) ACACAG/TAAATC 1 -- int10--------
    rs1405870101,2
    --75777313(+) TTTGCA/GTTCAA 1 -- int10--------
    rs111435101,2
    F,H--75777381(+) TCTGCC/TATGTT 1 -- int17Minor allele frequency- T:0.09NS EA WA NA 778
    rs625415531,2
    C--75777421(+) CTATAC/TAATTT 1 -- int14Minor allele frequency- T:0.12NA WA EA 360
    rs1157984621,2
    F--75777435(+) CTTAAC/TGAAAG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1861443661,2
    --75777462(+) TTTCAA/GTCACA 1 -- int10--------
    rs1909986351,2
    C--75777764(+) TTTGCT/CTTCTC 2 /P /L mis11Minor allele frequency- C:0.00EU 1321
    rs734916481,2
    C--75777818(+) TTATAG/AAGACT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs601703151,2
    C--75778193(+) GGGATC/TAAATT 1 -- int12Minor allele frequency- T:0.04WA 120
    rs1862653461,2
    --75778199(+) AAATTC/TCAACA 1 -- int10--------
    rs132937461,2
    C,F,H--75778238(+) ACCATC/TGCAAG 1 -- int119Minor allele frequency- T:0.19NS EA NA CSA WA 2226
    rs412778911,2
    --75778243(+) CGCAAG/ATAAAA 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1160463911,2
    F--75778291(+) ATACCT/CTTTTC 1 -- int11Minor allele frequency- C:0.03WA 118
    rs27951181,2
    C,F,O,H--75778370(+) CTTACA/GATAGA 1 -- int1100Minor allele frequency- G:0.05NS EA NA PA EU CA WA 7467
    rs1153625051,2
    C,F--75778451(+) AGGGTA/GAGGAA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1461193281,2
    C--75778584(+) AATGA-/GGCATG 1 -- int10--------
    rs1907797021,2
    --75778624(+) TAGTCG/TTTGTA 1 -- int10--------
    rs1829366711,2
    --75778717(+) TTGTTA/TGTTAA 1 -- int10--------
    rs1873051691,2
    --75778740(+) CCTTTC/TGTTGT 1 -- int10--------
    rs1912874761,2
    --75778856(+) GTCAAC/TTTATA 1 -- int10--------
    rs1443104181,2
    --75778896(+) AAGAGA/TATAGG 1 -- int10--------
    rs1464815101,2
    --75778917(+) ATAATA/TTATGC 1 -- int10--------
    rs1832562711,2
    --75779184(+) TAATAC/GGCACT 1 -- int10--------
    rs1877304521,2
    --75779295(+) AAATTA/GTTCAA 1 -- int10--------
    rs768136611,2
    F--75779339(+) ATTGCC/TCATAA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1927213531,2
    --75779415(+) TTAATA/GTATAT 1 -- int10--------
    rs1410378391,2
    --75779463(+) TGATGA/GTAGTC 1 -- int10--------
    rs1836893891,2
    --75779566(+) TTGATA/CTATTT 1 -- int10--------
    rs1879663921,2
    --75779580(+) TAAGAA/TTATGC 1 -- int10--------
    rs803554871,2
    F--75779637(+) TCAAAA/TTGCAA 1 -- int11Minor allele frequency- T:0.02NA 120
    rs785366061,2
    C--75779718(+) TAAAAA/CATCTT 1 -- int15Minor allele frequency- C:0.14NA WA EA 362
    rs1501660891,2
    --75779754(+) CTATAC/GAGCAT 1 -- int10--------
    rs413061571,2
    F--75779917(+) CTACTC/TTGATT 1 -- int11Minor allele frequency- T:0.02NA 120
    rs734916521,2
    C--75779958(+) TCTTTG/AACAAG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1490332551,2
    C,F--75780055(+) GAAAGG/AAGAAA 2 /R syn12Minor allele frequency- A:0.00NA EU 5873
    rs1446431431,2
    C--75780087(+) CAATAC/ACATCC 2 /N /T mis11Minor allele frequency- A:0.00NA 4552
    rs1846440301,2
    C--75780105(+) CAGAAA/GCTATC 2 N S mis10--------
    rs2007955281,2
    --75780125(+) GCAGAC/GGTAAC 2 L V mis10--------
    rs2003193411,2
    --75780144(+) TCTTTA/TTCTGG 1 -- int10--------
    rs170585631,2
    C,F,H--75780149(+) TTCTGG/CAATCT 1 -- int19Minor allele frequency- C:0.01NA NS EA 682
    rs1489047481,2
    --75780216(+) AACCCG/TTTTTC 1 -- int10--------
    rs111435111,2
    C,F,H--75780251(+) TACAGT/CGTTCC 1 -- int16Minor allele frequency- C:0.04NS EA WA 538
    rs777875871,2
    --75780385(+) AAAAGA/GTTTGG 1 -- int12Minor allele frequency- G:0.14CSA WA 120
    rs801759541,2
    F--75780407(+) GAAAAG/AACATG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs757496171,2
    --75780434(+) AAATTA/GGAATG 1 -- int14Minor allele frequency- G:0.09CSA WA 123
    rs123360531,2
    A--75780461(+) AAAAAA/CCAAAA 1 -- int1 trp30--------
    rs1151939211,2
    F--75780484(+) TAAATG/TAAGAA 1 -- int11Minor allele frequency- T:0.05WA 118
    rs625438681,2
    --75780532(+) CAAAAC/TTCAGA 1 -- int12Minor allele frequency- T:0.05NA 122
    rs783688171,2
    F--75780699(+) TAAGGG/AAAGAT 1 -- int11Minor allele frequency- A:0.03NA 120
    rs27951191,2
    C,F,A,H--75780714(+) TTGCTG/ATGGCT 1 -- int119Minor allele frequency- A:0.20NS EA WA NA 2342
    rs1171649621,2
    F--75780715(+) TGCTGT/AGGCTC 1 -- int11Minor allele frequency- A:0.02EA 120
    rs1434196201,2
    --75780760(+) TCACAG/TGCCGT 1 -- int10--------
    rs1140685441,2
    F--75780931(+) TTCTTT/CGAGTC 1 -- int11Minor allele frequency- C:0.04WA 118
    rs1462510701,2
    C--75781035(+) AAGTAC/TAGTAA 2 Y syn11Minor allele frequency- T:0.00NA 4534
    rs1435111801,2
    C--75781144(+) TAACTA/GGAAAT 1 -- int10--------
    rs788642701,2
    --75781234(+) TAGTGC/AATCTG 1 -- int11Minor allele frequency- A:0.01EA 120
    rs105120151,2
    C,F,H--75781246(+) TTCAAT/CTGAAG 1 -- int127Minor allele frequency- C:0.13NS NA EA WA 2588
    rs1814367831,2
    --75781255(+) AGCAAC/TGTAAA 1 -- int10--------
    rs27951201,2
    C,F,H--75781376(+) CAGGCT/GGGGCA 1 -- int19Minor allele frequency- G:0.18NS EA NA WA 782
    rs734916601,2
    C--75781436(+) AAATGC/TAACAT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1849271671,2
    --75781468(+) TCCTGC/GTCTAC 1 -- int10--------
    rs774737831,2
    F--75781473(+) GTCTAC/TTGCTT 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1458981231,2
    --75781475(+) CTACTA/GCTTGT 1 -- int10--------
    rs1893798631,2
    --75781483(+) TGTTAA/CTTGTA 1 -- int10--------
    rs1384758491,2
    --75781541(+) GCCTCC/TAAAAA 1 -- int10--------
    rs1809236961,2
    --75781564(+) AAAGAA/TCTCCC 1 -- int10--------
    rs1419693251,2
    --75781663(+) AGCTTG/TTTAAA 1 -- int10--------
    rs1506695601,2
    --75781721(+) TTTCTA/GACAAG 1 -- int10--------
    rs1849403621,2
    --75781734(+) CCCCAC/TTGATG 1 -- int10--------
    rs123425221,2
    C,F,H--75781745(+) CCAATG/TCTGTT 1 -- int14Minor allele frequency- T:0.01NS EA 420
    rs27951211,2
    C,F,H--75781764(+) GATCTC/TGACAA 1 -- int14Minor allele frequency- T:0.01NS EA 420
    rs1480371621,2
    --75781994(+) CCAAT-/GCCCCT 1 -- int10--------
    rs13420181,2
    C,F,O,A,H--75782131(-) TATTCT/CCCTTG 1 -- int124Minor allele frequency- C:0.25NS EA NA CSA WA 2472
    rs123395331,2
    C,F,H--75782168(+) GTTGCT/CCTTGA 1 -- int14Minor allele frequency- C:0.01NS EA 420
    rs1910239731,2
    --75782358(+) ATATGA/GATATT 1 -- int10--------
    rs2021422511,2
    --75782386(+) AATACA/CTCAAC 1 -- int10--------
    rs1418100711,2
    C,F--75782421(+) AGTGCG/ACCACA 2 /T /A mis12Minor allele frequency- A:0.00NA EU 5853
    rs1505914471,2
    C,F--75782445(+) TCTTTG/TCAGAG 2 A S mis11Minor allele frequency- T:0.00NA 4530
    rs2008438941,2
    --75782447(+) TTTGCA/CGAGAA 2 A syn10--------
    rs1818024571,2
    C--75782481(+) GTACCA/GTTCTA 1 -- int10--------
    rs13420171,2
    C,F,A,H--75782510(-) TAATTC/TTTCCT 1 -- int1 trp335Minor allele frequency- T:0.43NS EA NA WA CSA 3332
    rs170585701,2
    C,F,H--75782555(+) AAAATC/GTCACA 1 -- int113Minor allele frequency- G:0.02NA NS EA 1522
    rs19812881,2
    C,F,O,A,H--75782655(-) AAAAAA/GGCACC 1 -- int128Minor allele frequency- G:0.36NS EA NA WA CSA 3946
    rs734916661,2
    C--75782700(+) ATTTAC/TGGCTC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs795810731,2
    C--75782738(+) ACCACG/AGGAAG 1 -- int13Minor allele frequency- A:0.08CSA WA 121
    rs28112241,2
    C,F,H--75782864(+) TTATGC/TCACAG 1 -- int16Minor allele frequency- T:0.02NS EA WA 540
    rs1168332611,2
    F--75782912(+) TAAGGA/GTGTAG 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1148869481,2
    --75782926(+) GATGTA/TTTTGA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1860385871,2
    --75782963(+) TGTCTC/GACATG 1 -- int10--------
    rs1917929681,2
    --75783060(+) CAGCTC/TCAAAA 1 -- int10--------
    rs1832526101,2
    --75783066(+) CAAAAC/TAAGGA 1 -- int10--------
    rs781484251,2
    --75783083(+) CAGAGA/GGAGAG 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1395502511,2
    --75783106(+) CTAACC/TATTTG 1 -- int10--------
    rs1442684631,2
    --75783118(+) ATAATA/GTGAAG 1 -- int10--------
    rs101196051,2
    C,F,H--75783255(+) GTAATG/CATGAA 1 -- int14Minor allele frequency- C:0.01NS EA 420
    rs1866574411,2
    --75783345(+) TAACAC/TCTGAA 1 -- int10--------
    rs1486619311,2
    --75783440(+) ACACAC/TAGGCT 1 -- int10--------
    rs746172991,2
    F--75783463(+) GTAACA/GTAACC 1 -- int11Minor allele frequency- G:0.04WA 118
    rs1421437641,2
    --75783506(+) ACACTA/GGAAGA 1 -- int10--------
    rs105771901,2
    C--75783797(+) GTAAG-/GTGTGTG 1 -- int10--------
    rs764840111,2
    F--75783840(+) AGTTTC/TTCTAT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs37399591,2
    C,F,A,H--75783937(+) CATTTA/GTTTTG 1 -- int130Minor allele frequency- G:0.41EA NA NS WA CSA EU 5395
    rs1392287211,2
    C,F--75784045(+) GTATGG/ATATCT 2 /D /G mis11Minor allele frequency- A:0.00NA 4550
    rs1511958061,2
    --75784194(+) ATTATA/GGTGTA 1 -- int10--------
    rs28112251,2
    C,F,H--75784206(+) ACTTCA/GTGAGT 1 -- int15Minor allele frequency- G:0.02NS EA WA 422
    rs1141968061,2
    F--75784243(+) ACTAGT/AGAGTT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs28112261,2
    C,F,O,A,H--75784264(+) ATACTA/GGGTAC 1 -- int128Minor allele frequency- G:0.39NA NS EA WA CSA 2493
    rs1470195601,2
    --75784266(+) ACTGGA/GTACAT 1 -- int10--------
    rs126839761,2
    C,H--75784270(+) GGTACA/GTTTTT 1 -- int11Minor allele frequency- G:0.25NA 4
    rs108692311,2
    C,F,A,H--75784327(+) AAGCAA/GAATAT 1 -- int127Minor allele frequency- G:0.50NS EA NA WA CSA 2361
    rs1824283631,2
    --75784482(+) TAAGAA/GTGTTA 1 -- int10--------
    rs1867048061,2
    --75784931(+) GTTTCG/TACTAA 1 -- int10--------
    rs1119293391,2
    C,F--75785014(+) TGTGGA/CGGAAA 2 G syn11Minor allele frequency- C:0.01NA 4546
    rs1458642571,2
    C--75785053(+) ATGATC/TAGAAG 1 -- ut311Minor allele frequency- T:0.00EU 1229
    rs1997768861,2
    --75785059(+) AGAAGA/GCTTTA 1 -- ut310--------
    rs95611,2
    A,H--75785105(+) AGTTTC/TTTCAA 1 -- ut31 ese35Minor allele frequency- T:0.00MN NS EA 600
    rs1926891621,2
    --75785203(+) CATTTC/TTTAAA 1 -- ut310--------
    rs1833397791,2
    --75785205(+) TTTTTA/TAAAAA 1 -- ut310--------
    rs1886202451,2
    --75785298(+) ATGACA/GTCACA 1 -- ut310--------
    rs1931561721,2