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ANXA1 Gene

protein-coding   GIFtS: 71
GCID: GC09P075766

Annexin A1


(Previous symbols: ANX1, LPC1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Annexin A11 2     annexin-12
LPC11 2 3 5     calpactin-22
ANX11 2 3     chromobindin-92
Calpactin II2 3     Annexin-13
Lipocortin I2 3     Calpactin-23
Phospholipase A2 Inhibitory Protein2 3     Chromobindin-93
p352 3     Annexin I3
Annexin I (Lipocortin I)2     

External Ids:    HGNC: 5331   Entrez Gene: 3012   Ensembl: ENSG000001350467   OMIM: 1516905   UniProtKB: P040833   

Export aliases for ANXA1 gene to outside databases

Previous GC identifers: GC09P066811 GC09P067623 GC09P069336 GC09P071223 GC09P072996 GC09P074956 GC09P045589


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANXA1 Gene:
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of
approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane.
Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity.
Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins
and leukotrienes, annexin I may have potential anti-inflammatory activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for ANXA1 Gene:
ANXA1 (annexin A1) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Gene Wiki entry for ANXA1 (Annexin A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANXA1 gene promoter:
         C/EBPbeta   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   AREB6   POU2F1   POU2F1a   STAT3   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ANXA1 promoter sequence
   Search Chromatin IP Primers for ANXA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANXA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q21.13

ANXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P075766:  view genomic region     (about GC identifiers)

Start:
75,766,673 bp from pter      End:
75,785,309 bp from pter
Size:
18,637 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083 (See protein sequence)
Recommended Name: Annexin A1  
Size: 346 amino acids; 38714 Da
Subunit: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity)
3 PDB 3D structures from and Proteopedia for ANXA1:
1AIN (3D)        1BO9 (3D)        1QLS (3D)    

Explore the universe of human proteins at neXtProt for ANXA1: NX_P04083

Explore proteomics data for ANXA1 at MOPED

Post-translational modifications: 

  • Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in
    loss of the inhibitory activity1
  • Ubiquitination2 at Lys58, Lys166, Lys274
  • Glycosylation2 at Ser37
  • Modification sites at PhosphoSitePlus

  • See ANXA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000691.1  
    ENSEMBL proteins: 
     ENSP00000257497   ENSP00000412489   ENSP00000414013   ENSP00000366109  
    Reactome Protein details: P04083

    ANXA1 Human Recombinant Protein Products:

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    Novus Biologicals ANXA1 Proteins
    Novus Biologicals ANXA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ANXA1
    Cloud-Clone Corp. Proteins for ANXA1

     
    Search eBioscience for Proteins for ANXA1 

    ANXA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANXA1
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    Abcam antibodies for ANXA1
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ANXA1
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    Search eBioscience for ELISAs for ANXA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    ANXA: Annexins

    4 InterPro protein domains:
     IPR018502 Annexin_repeat
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR002388 AnnexinI

    Graphical View of Domain Structure for InterPro Entry P04083

    ProtoNet protein and cluster: P04083

    2 Blocks protein domains:
    IPB001464 Annexin
    IPB002388 Annexin type I signature


    UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    Find genes that share domains with ANXA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANXA1_HUMAN, P04083
    Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
    protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

         Genatlas biochemistry entry for ANXA1:
    annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of
    the organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid
    feadback action in the hypothalamo-hypophysial system

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity ----
    GO:0005102receptor binding TAS10882119
    GO:0005198structural molecule activity IDA10908733
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with ANXA1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ANXA1:
     Decreased viability 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Anxa1):
     adipose tissue  cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     nervous system  skeleton  tumorigenesis 

    Find genes that share phenotypes with ANXA1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANXA1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANXA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANXA1

    miRNA
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    miRTarBase miRNAs that target ANXA1:
    hsa-mir-30a-5p (MIRT028650), hsa-mir-335-5p (MIRT018638), hsa-mir-26b-5p (MIRT030065), hsa-mir-196a-5p (MIRT000709)

    Block miRNA regulation of human, mouse, rat ANXA1 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidANXA1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANXA1

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    GenScript: all cDNA clones in your preferred vector: ANXA1 (NM_000700)
    Sino Biological Human cDNA Clone for ANXA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANXA1_HUMAN, P04083: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity).
    Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of
    ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and
    alveolar macrophages (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular5
    cytosol4
    plasma membrane4
    endosome2
    mitochondrion2
    nucleus2
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001533cornified envelope IDA10908733
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS16130169

    Find genes that share ontologies with ANXA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANXA1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Formyl peptide receptors bind formyl peptides and many other ligands0.00
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Spinal Cord Injury
    Spinal Cord Injury
    5Selected targets of CREB1
    Selected targets of CREB1


    Find genes that share SuperPaths with ANXA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ANXA1
        Ca, cAMP and Lipid Signaling

    4 BioSystems Pathways for ANXA1
        Integrated Breast Cancer Pathway
    Spinal Cord Injury
    Prostaglandin Synthesis and Regulation
    Integrated Pancreatic Cancer Pathway


    3 Reactome Pathways for ANXA1
        Formyl peptide receptors bind formyl peptides and many other ligands
    G alpha (q) signalling events
    G alpha (i) signalling events


        Pathway & Disease-focused RT2 Profiler PCR Array including ANXA1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANXA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANXA1 (P040831, 2, 3 ENSP000002574974) via UniProtKB, MINT, STRING, and/or I2D (see all 310)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBB1O002132, 3, ENSP000002994024MINT-8247707 I2D: score=2 STRING: ENSP00000299402
    ENSG00000272333Q9UMN62, 3MINT-8247832 I2D: score=2 
    KMT2BQ9UMN62, 3MINT-8247832 I2D: score=2 
    C14orf1Q9UKR52, 3MINT-8247720 I2D: score=2 
    CCT7Q998322, 3MINT-8247753 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001780neutrophil homeostasis IMP--
    GO:0002674negative regulation of acute inflammatory response IEA--
    GO:0006928cellular component movement TAS10882119
    GO:0006954inflammatory response TAS10882119
    GO:0007049cell cycle ----

    Find genes that share ontologies with ANXA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ANXA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ThiolutinBacterial RNA polymerase inhibitor[87-11-6]
    Heparin sodium saltAnticoagulant[9041-08-1]
    Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor[154303-05-6]
    RGDS peptideIntegrin binding sequence; inhibits integrin receptor function[91037-65-9]
    Ac2-26Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation[151988-33-9]

    1 HMDB Compound for ANXA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for ANXA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Hydrocortisone11beta-Hydroxycortisone (see all 16)50-23-7targetagonist1712816 17139284 11142771 17016423 8060156
    DexamethasoneDesametasone (see all 9)50-02-2targetagonist17644190 17076770 17158208 16883066
    Amcinonide-- 51022-69-6targetagonist17139284 17016423 7981624

    Selected Novoseek inferred chemical compound relationships for ANXA1 gene (see all 56)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hdmnkvldl 84.9 2 8818992 (1), 1793057 (1)
    phosphatidylserine 62.1 29 8179621 (3), 7627125 (1), 12744815 (1), 15381697 (1) (see all 16)
    phospholipid 59.7 33 8379935 (7), 2138536 (1), 1310621 (1), 8485141 (1) (see all 20)
    calcium 55 126 11142771 (6), 9299392 (5), 18283055 (4), 1469069 (3) (see all 58)
    arachidonic acid 49.2 16 2064175 (2), 8260938 (2), 2137129 (2), 12845669 (1) (see all 10)
    dexamethasone 45.3 54 8256657 (6), 12236584 (5), 17644190 (4), 14668092 (3) (see all 17)
    glyceraldehyde 3-phosphate 44.7 7 16220529 (1), 17268060 (1), 15274135 (1), 19899082 (1) (see all 7)
    geneticin 32.2 1 7764687 (1)
    phosphatidylcholine 30.4 17 16307464 (2), 12845669 (1), 7654693 (1), 1387325 (1) (see all 5)
    p-opc 30 7 16307464 (3), 18237543 (2)



    Find genes that share compounds with ANXA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANXA1 gene: 
    NM_000700.1  

    Unigene Cluster for ANXA1:

    Annexin A1
    Hs.494173  [show with all ESTs]
    Unigene Representative Sequence: AK074480
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257497(uc004ajf.1) ENST00000468639 ENST00000456643 ENST00000415424
    ENST00000376911(uc004ajg.1) ENST00000495713 ENST00000489109 ENST00000491192

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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ANXA1
      QuantiFast Probe-based Assays in human, mouse, rat ANXA1

    Additional mRNA sequence: 

    AB451274.1 AB451401.1 AK023330.1 AK074480.1 AK296808.1 AK311684.1 BC001275.1 BC018683.1 
    BC034157.1 BC035993.1 BT019896.1 BT019916.1 BT019917.1 CR407684.1 X05908.1 

    Selected DOTS entries (see all 49):

    DT.95080391  DT.100890399  DT.95202652  DT.100765659  DT.100890413  DT.100890422  DT.100890394  DT.100890395 
    DT.121161786  DT.100890415  DT.95340497  DT.95223581  DT.92045136  DT.92466092  DT.100040129  DT.100890410 
    DT.100890409  DT.91793108  DT.91703452  DT.91949347  DT.121161854  DT.100890404  DT.92466082  DT.92466099 

    Selected AceView cDNA sequences (see all 1569):

    CD709026 BG748968 CA419768 CA414702 CB159233 CB134078 CB409715 AW439690 
    CB147659 BM762676 BQ228510 BE163625 AA360576 CB134806 AU137564 BQ962052 
    BQ775829 CA405627 BQ962446 CA443862 AU137423 AU135495 BM476344 BU684426 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:              -     -     -     -     -                 -           -                 -                             -                 -                     
    SP2:                                                        -           -                 -                             -                 -                     
    SP3:              -           -     -     -                 -           -                 -                             -                                       
    SP4:                                                                                      -                             -                                       
    SP5:                    -     -     -     -                 -           -                 -                                                                     


    ECgene alternative splicing isoforms for ANXA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANXA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAAGATGT
    ANXA1 Expression
    About this image


    ANXA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 34) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             Line H9 (Naive)
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Cerebral Cortex
             Dorsal forebrain-like neurons
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Laryngeal Cartilage
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocytes Zeugopod Epiphyseal End
             Bone Marrow
    ANXA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANXA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.494173
        Pathway & Disease-focused RT2 Profiler PCR Array including ANXA1: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ANXA1
    OriGene qSTAR qPCR primer pairs in human, mouse for ANXA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANXA1
    QuantiTect SYBR Green Assays in human, mouse, rat ANXA1
    QuantiFast Probe-based Assays in human, mouse, rat ANXA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANXA1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anxa11 , 5 annexin A11, 5 86.61(n)1
    87.57(a)1
      19 (13.83 cM)5
    169521  NM_010730.21  NP_034860.21 
     203734285 
    chicken
    (Gallus gallus)
    Aves ANXA11 annexin A1 75.07(n)
    78.59(a)
      404271  NM_206906.1  NP_996789.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA16
    annexin A1
    76(a)
    1 ↔ 1
    2(47804835-47822960)
    African clawed frog
    (Xenopus laevis)
    Amphibia anxa1-prov2 annexin A1 77.96(n)    BC053786.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anxa1a2 annexin A1a 73.36(n)   334724  AY178793.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nex-23 Annexin 42(a)
    (best of 3)
      III(10397630-10399688)   --


    ENSEMBL Gene Tree for ANXA1 (if available)
    TreeFam Gene Tree for ANXA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANXA1 gene
    ANXA32  ANXA62  ANXA52  ANXA92  ANXA22  ANXA72  ANXA82  ANXA112  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA1 using alignment to 6 protein entries:     ANXA1_HUMAN (see all proteins):
    ANXA2    ANXA2P2    DKFZp686H02120    ANXA13    ANXA7    ANXA8
    ANXA11    ANXA3    ANXA4    ANXA5    ANXA8L2    ANXA6
    ANXA8L1    ANXA9    ANXA10

    Find genes that share paralogs with ANXA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ANXA1 (see all 449)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127652951,2
    C,F--75764783(+) TAGTGG/ACTTTC 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs23103121,2
    C,F,O,A,H--75764998(+) CAAAGC/AAAAAT 1 -- us2k124Minor allele frequency- A:0.19NA NS EA WA 2694
    rs1390908591,2
    --75765039(+) TTTTAC/TAAAAA 1 -- us2k10--------
    rs1423959281,2
    --75765093(+) AGGAAA/TGTTCC 1 -- us2k10--------
    rs37583551,2
    C,F,H--75765100(+) TTCCAA/GTAGTT 1 -- us2k15Minor allele frequency- G:0.02EA NS 1898
    rs1929154221,2
    --75765212(+) TATTAA/GAAAGT 1 -- us2k10--------
    rs785905931,2
    C--75765229(+) ACATCT/CGTCAA 1 -- us2k13Minor allele frequency- C:0.08CSA WA 121
    rs1851810361,2
    --75765234(+) TGTCAA/GGATCA 1 -- us2k10--------
    rs339429881,2
    C--75765264(+) ACTTA-/ACTTGT 1 -- us2k10--------
    rs1170381621,2
    F--75765351(+) GATTAG/CATGAT 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1486260531,2
    --75765359(+) GATCAC/TCCTAC 1 -- us2k10--------
    rs27951081,2
    C,F,O,A,H--75765478(+) TTTTAT/CGTGAA 1 -- us2k121Minor allele frequency- C:0.25NA NS EA WA 2478
    rs101215851,2
    C,F,H--75765509(+) AAAAAG/TAACAA 1 -- us2k1 trp38Minor allele frequency- T:0.11NS EA WA NA 778
    rs1421246821,2
    --75765563(+) TTACAA/CCTGTG 1 -- us2k10--------
    rs1896473811,2
    --75765658(+) TTTCCA/TCCATT 1 -- us2k10--------
    rs1510803621,2
    --75765728(+) ATTTTA/GTAGGT 1 -- us2k10--------
    rs1916186641,2
    --75765785(+) TGTATC/TAAAAT 1 -- us2k10--------
    rs760027931,2
    C,F--75765972(+) CTTCTA/GTATTT 1 -- us2k12Minor allele frequency- G:0.05CSA NA 122
    rs1126162851,2
    F--75766141(+) TAGATG/AATGCT 1 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs770261811,2
    C,F--75766144(+) ATAATG/ACTCCT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs756952651,2
    F--75766169(+) AAACAG/ACTAGG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1120377491,2
    C,F--75766271(+) ATAACG/AAGACC 1 -- us2k12Minor allele frequency- A:0.08CSA WA 120
    rs27951091,2
    C,F--75766409(+) TGTTTG/TTTGGT 1 -- us2k1 tfbs31Minor allele frequency- T:0.05WA 118
    rs27951101,2
    C,F,A,H--75766412(+) TTGTTG/TGTTTG 1 -- us2k19Minor allele frequency- T:0.29NA WA EA 370
    rs1449044101,2
    --75766432(+) GAAGGC/TAACAT 1 -- us2k10--------
    rs1837295371,2
    --75766446(+) TTTTAG/TTCTAC 1 -- us2k10--------
    rs1171531351,2
    C--75766500(+) TTGGGG/ACAGAT 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1881459911,2
    --75766637(+) GAGTAA/GTTTTG 1 -- us2k10--------
    rs1479686421,2
    --75766751(+) ATCCTA/GTAAAA 1 -- us2k10--------
    rs1820071661,2
    --75766832(+) AGGTAC/GAGATA 1 -- ut510--------
    rs11310721,2
    C,F,H--75766838(+) AGATAA/GAGGTA 1 -- ut5114Minor allele frequency- G:0.16EA NA NS WA 2196
    rs783307921,2
    C,F--75766875(+) TTGGTT/GGTTTT 1 -- int11Minor allele frequency- G:0.13WA 118
    rs1872115711,2
    --75766957(+) ATAAGA/TCATTC 1 -- int10--------
    rs1175200901,2
    F--75767067(+) GATAAG/ATTTGC 1 -- int11Minor allele frequency- A:0.04EA 120
    rs795516651,2
    F--75767157(+) AAGAAC/TGTGTT 1 -- int10--------
    rs1904458871,2
    --75767177(+) CTTCCC/TCTTGA 1 -- int10--------
    rs1818068111,2
    C--75767200(+) CAAGAA/GCTGTG 1 -- int10--------
    rs767798271,2
    C,F--75767240(+) GCTTTT/CTGGGG 1 -- int11Minor allele frequency- C:0.14WA 118
    rs1470251781,2
    --75767276(+) GCTGCA/CGGGAA 1 -- int10--------
    rs1452075061,2
    --75767415(+) TTATGC/TTATTT 1 -- int10--------
    rs1491563481,2
    --75767435(+) AGGTCC/TGCTTA 1 -- int10--------
    rs759021961,2
    C,F--75767585(+) AGGGGA/TATGTC 1 -- int13Minor allele frequency- T:0.08CSA WA 121
    rs1124662731,2
    C,F--75767695(+) ACTAGC/TGTTGG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1868297831,2
    --75767952(+) AATGCA/TCATTG 1 -- int10--------
    rs1482416481,2
    C--75768023(+) AAGTGA/GCAGTA 1 -- int10--------
    rs1118391681,2
    C,F--75768037(+) CCCTAG/CCTCCA 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs1903714471,2
    --75768064(+) GCACAC/TAGCCA 1 -- int10--------
    rs27951111,2
    C,F--75768078(+) TTTAAC/AAGATG 1 -- int11Minor allele frequency- A:0.05WA 118
    rs1455517461,2
    C--75768083(+) CAGATA/GTTGAC 1 -- int10--------
    rs108692291,2
    C,F,A,H--75768094(+) AAAATA/GGTTAA 1 -- int19Minor allele frequency- G:0.23NS EA NA 538
    rs604032321,2
    C,F--75768163(+) AGAAGG/CTCTGC 1 -- int11Minor allele frequency- C:0.50WA 2
    rs43015021,2
    C,F,A,H--75768183(+) TTTCTG/AAATAT 1 -- int115Minor allele frequency- A:0.09NS EA NA WA 1410
    rs1147241441,2
    C,F--75768209(+) TAGACC/TTATTA 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1112454121,2
    C,F--75768334(+) TTCATC/TAGGAA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1505017901,2
    C--75768379(+) TCATTA/GTGCTA 1 -- int10--------
    rs1383893881,2
    --75768437(+) TCAGAA/GCTGTA 1 -- int10--------
    rs1825861611,2
    --75768488(+) ATAAAC/TGAAGA 1 -- int10--------
    rs750719481,2
    C,F--75768836(+) TGAAGT/GCAGGA 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1163624201,2
    C,F--75769008(+) AAGAAC/AACCCT 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1492670961,2
    C--75769210(+) TGAAAA/CCTGCT 1 -- int10--------
    rs1445101631,2
    --75769224(+) GTCTGC/TGCAAG 1 -- int10--------
    rs1409145761,2
    --75769225(+) TCTGCA/GCAAGT 1 -- int10--------
    rs2009757001,2
    C--75769281(+) CACTGA/GTCATG 1 -- int11Minor allele frequency- G:0.00EU 569
    rs454989991,2
    C,F--75769299(+) CTTTTT/CGGTCA 1 -- int12Minor allele frequency- C:0.02NA EU 689
    rs1854903421,2
    --75769390(+) TATGTC/TGCCCA 1 -- int10--------
    rs122385071,2
    C--75769485(+) GAGTAG/TATGGG 1 -- int10--------
    rs1898933801,2
    --75769812(+) CATTGC/TTGTTA 1 -- int10--------
    rs117909431,2
    C,H--75769843(+) TAGTTC/TTAGAT 1 -- int14Minor allele frequency- T:0.00NS EA 418
    rs1475121471,2
    --75769891(+) TTCCTC/GTGTCA 1 -- int10--------
    rs605219531,2
    C,F--75769917(+) GGTAGC/ACTTTC 1 -- int11Minor allele frequency- A:0.08EA 120
    rs27951121,2
    C,F,A,H--75769950(+) TGAAGC/GGGGGG 1 -- int115Minor allele frequency- G:0.24NS EA NA WA 1204
    rs1826323931,2
    --75770067(+) AAGACC/TATTAA 1 -- int10--------
    rs122385621,2
    H--75770076(+) AATTAG/AAAGAA 1 -- int14Minor allele frequency- A:0.00NS EA 420
    rs27951131,2
    C,F,O,A,H--75770132(+) TGGCCA/TATTTC 1 -- int132Minor allele frequency- T:0.13EA NA NS WA 3396
    rs786263391,2
    C,F--75770178(+) CTTAGT/CTTTAG 1 -- int12Minor allele frequency- C:0.07CSA WA 119
    rs1888749561,2
    --75770270(+) GCAAGA/CTTTAT 1 -- int10--------
    rs1401387261,2
    --75770485(+) GCCCTG/TAACCA 1 -- int10--------
    rs133018701,2
    H--75770605(+) ATTCCG/CTTTTT 1 -- int14Minor allele frequency- C:0.00NS EA 418
    rs1932199171,2
    --75770609(+) CGTTTC/TTCTCT 1 -- int10--------
    rs1151990481,2
    F--75770683(+) TATCCA/GAATAC 1 -- int11Minor allele frequency- G:0.03WA 118
    rs764912411,2
    C--75770774(+) GACTT-/AAAC  
            
    AACTT
    1 -- int10--------
    rs1835798341,2
    --75770869(+) AGTATG/TTTTTA 1 -- int10--------
    rs357286111,2
    C--75770879(+) AAAAA-/ACAGTA 1 -- int10--------
    rs123446701,2
    C,F,H--75770912(+) TATAAC/TGTTTA 1 -- int110Minor allele frequency- T:0.10NS EA NA WA 914
    rs1872977101,2
    --75770999(+) TTTTAA/TTTGCT 1 -- int10--------
    rs111435091,2
    F,H--75771013(+) TGAAAA/GGAATG 1 -- int15Minor allele frequency- G:0.08NS EA NA 540
    rs3704126841,2
    C--75771020(+) AATGG-/AATAATAA 1 -- int10--------
    rs2000054481,2
    --75771034(+) ATAAT-/AAATAA 1 -- int10--------
    rs2011981131,2
    --75771037(+) AATAA-/TAATAA 1 -- int10--------
    rs1995456931,2
    C--75771067(+) AATAT-/AAATAAA 1 -- int10--------
    rs108692301,2
    A--75771068(+) atataA/Tataaa 1 -- int10--------
    rs1481288801,2
    C--75771071(+) AAATA-/AATAAAT/
    AATAAATAAAT
    AATAA
    1 -- int10--------
    rs798086921,2
    F--75771270(+) CAATTA/TAGAAG 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1429840921,2
    --75771304(+) CAACCA/GCAATT 1 -- int10--------
    rs27951141,2
    C,F,O,A,H--75771314(+) TGCATG/CAAACT 1 -- int141Minor allele frequency- C:0.39EA NA NS WA CSA 5252
    rs1839475361,2
    --75771356(+) AATTGC/TGGGTT 1 -- int10--------
    rs770195051,2
    C,F--75771456(+) CACAGA/GTGACA 1 -- int11Minor allele frequency- G:0.10EA 120
    rs1883834191,2
    --75771474(+) AATAAA/GAGCAA 1 -- int10--------
    rs170585511,2
    C,F,H--75771557(+) GCAACT/CCCAGT 1 -- int18Minor allele frequency- C:0.01NA EA NS 486
    rs1122731021,2
    C--75771744(+) TGAAAC/TAGAAT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs47452181,2
    C,F,A,H--75771935(+) GATAGC/TAATTC 1 -- int122Minor allele frequency- T:0.08NS EA NA WA 2766
    rs1912918371,2
    --75772064(+) TGTTGC/GGTGGG 1 -- int10--------
    rs776228571,2
    C--75772072(+) GGGAAA/GATATG 1 -- int13Minor allele frequency- G:0.07CSA WA 121
    rs1843437351,2
    --75772103(+) CTCAAA/TTAGGA 1 -- int10--------
    rs1409529721,2
    --75772218(+) TACAAC/TTAAAA 1 -- int10--------
    rs790623041,2
    C,F--75772274(+) CCTTAT/CAAATG 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1497984141,2
    --75772298(+) GGAGTA/GGTAGC 1 -- int10--------
    rs1457825101,2
    --75772336(+) AGGCCA/GAGGCG 1 -- int10--------
    rs1406157781,2
    --75772381(+) CCTAGA/CCAACA 1 -- int10--------
    rs1470168341,2
    C--75772395(+) TGAAAA/TCCTGT 1 -- int10--------
    rs1904387171,2
    --75772506(+) CGGAGG/TTTGCA 1 -- int10--------
    rs1823126611,2
    --75772548(+) CTGGGC/TGACAG 1 -- int10--------
    rs1868735071,2
    --75772611(+) TTTCAG/TCTAGC 1 -- int10--------
    rs176526101,2
    C,F--75772639(+) CTCTCA/GTTAAT 1 -- int1 ese33Minor allele frequency- G:0.01NA 142
    rs1410771531,2
    C--75772697(+) ATCTTA/GTCTAT 1 -- int10--------
    rs27951151,2
    C,F,H--75772797(+) GAAACC/TCATTA 1 -- int15Minor allele frequency- T:0.03NS EA WA 538
    rs360295211,2
    C,F--75772828(+) GGACAC/TATTGA 1 -- int13Minor allele frequency- T:0.33NA 6
    rs1136056411,2
    C,F--75772836(+) TGAAGC/TTTCTT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs734916391,2
    C,F--75772842(+) TTCTTG/CTTTCA 1 -- int11Minor allele frequency- C:0.50WA 2
    rs1432028661,2
    --75772867(+) TTCTCA/GCTCCA 1 -- int10--------
    rs28112221,2
    C,F,H--75772921(+) AACTTT/CTCTGC 1 -- int1 ese35Minor allele frequency- C:0.03NS EA WA 538
    rs123790091,2
    C,F,H--75773029(+) ACTAGC/GTTTAA 1 -- int111Minor allele frequency- G:0.02NS EA NA 688
    rs287201051,2
    C,F--75773097(+) ATGGTG/AGGTGG 1 -- int13Minor allele frequency- A:0.13WA NA 122
    rs27951161,2
    C,F,O,A,H--75773161(+) TGCTTA/GCTTGT 1 -- int1 ese322Minor allele frequency- G:0.17NA NS EA WA 2486
    rs2021585671,2
    --75773403(+) GCATTA/TGTTTT 1 -- int10--------
    rs1857235001,2
    C--75773415(+) TAAAAA/GCATCT 1 -- int10--------
    rs1136848661,2
    C--75773518(+) ATGTTC/GTAAGT 1 -- spd10--------
    rs2010415411,2
    --75773527(+) GTAGAA/GTGATA 1 -- int10--------
    rs1485321111,2
    C--75773610(+) TCTTAG/ACAAAC 1 -- spa11Minor allele frequency- A:0.00NA 4536
    rs2005004501,2
    --75773640(+) GGTCCC/TGGATC 2 P syn10--------
    rs1997727081,2
    --75773643(+) CCCGGA/CTCAGC 2 G syn10--------
    rs353047641,2
    C,F--75773649(+) TCAGCA/G/TGTGAG 3 A syn12NA 4624
    rs115570521,2
    H--75773671(+) CCTTCA/GATCCA 2 N D mis1 ese34Minor allele frequency- G:0.00NS EA 406
    rs1481877211,2
    C--75773682(+) TCCTCA/GGATGT 2 S syn10--------
    rs1411752211,2
    C--75773707(+) AGGCCA/TTAATG 2 I L mis10--------
    rs2001057391,2
    C--75773724(+) GGTAAC/TGTGTT 1 -- int11Minor allele frequency- T:0.00EU 1323
    rs1901433591,2
    C--75773754(+) CTGGAC/TATTTC 1 -- int10--------
    rs28112231,2
    C,F,H--75773842(+) ATTTCT/CTTGCC 1 -- int15Minor allele frequency- C:0.03NS EA WA 538
    rs749318911,2
    C--75773886(+) GAAATT/CGTGTT 1 -- int11Minor allele frequency- C:0.01EA 120
    rs785732821,2
    F--75773944(+) TCTAGC/AAGAAA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1507418311,2
    --75773961(+) GCTGAA/GATTAA 1 -- int10--------
    rs123485351,2
    C,F,H--75774052(+) TTTCTC/TACTCG 1 -- int1 trp312Minor allele frequency- T:0.07NS EA NA WA 1310
    rs1379668161,2
    --75774151(+) GTTAAG/TAAGTT 1 -- int10--------
    rs752971271,2
    C,F--75774216(+) TTGGTG/ATTAAA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs101143501,2
    C,F,H--75774238(+) CTTTAT/CTTCCA 1 -- int14Minor allele frequency- C:0.01NS EA 420
    rs764591321,2
    C--75774283(+) CTAAGC/TGAAAC 2 R * stg10--------
    rs1160801951,2
    C,F--75774306(+) CAACAG/CATCAA 2 /H /Q mis12Minor allele frequency- C:0.00WA NA 4668
    rs1826421211,2
    C--75774348(+) AGTTAA/GAGTGG 1 -- int10--------
    rs1860224901,2
    --75774481(+) TTTATC/GCACTT 1 -- int10--------
    rs120008401,2
    C,F,H--75774574(+) TCTGGG/TGACAA 1 -- int117Minor allele frequency- T:0.05NS EA NA WA 2326
    rs1920544441,2
    --75774771(+) ACTATA/GTAATT 1 -- int10--------
    rs1840412041,2
    --75774834(+) GGAAAA/CATGAA 1 -- int10--------
    rs1475008901,2
    --75775083(+) TAGGGA/TTGAGT 1 -- int10--------
    rs175744381,2
    C,F,H--75775116(+) TAATAT/CCACAT 1 -- int17Minor allele frequency- C:0.00NA NS EA 562
    rs10503051,2
    C,F,H--75775235(+) GTTTTA/GGCTCT 2 L syn121Minor allele frequency- G:0.14NS EA NA WA EU 8206
    rs1141698351,2
    C,F--75775331(+) CAAGAG/AGATGT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1875165951,2
    C--75775338(+) ATGTAC/TTGGGC 1 -- int10--------
    rs2019279571,2
    --75775339(+) TGTATA/TGGGCA 1 -- int10--------
    rs101196541,2
    C,F,H--75775483(+) ACCTTC/TCATGT 1 -- int16Minor allele frequency- T:0.06NS EA WA 540
    rs1905307971,2
    --75775562(+) TGTTTG/TAGGGC 1 -- int10--------
    rs781001871,2
    F--75775597(+) ATTAAA/GTGTTG 1 -- int10--------
    rs1827197211,2
    --75775624(+) AATGAC/TAGAGT 1 -- int10--------
    rs1870898061,2
    --75775630(+) AGAGTC/GAAACA 1 -- int10--------
    rs1928445471,2
    C--75775672(+) CTTGCA/TTGAAG 1 -- int10--------
    rs2009904831,2
    C--75775813(+) GGGTAA/GGTTGT 1 -- int10--------
    rs2001436101,2
    --75775837(+) CCAAAC/TGCCTT 1 -- int10--------
    rs1844772921,2
    --75775888(+) GTCTAC/TGGTAA 1 -- int10--------
    rs38372991,2
    C--75776181(+) TTTTT-/TGAAAA 1 -- int10--------
    rs1877708101,2
    --75776219(+) ATCTCC/TTAACA 1 -- int10--------
    rs70318461,2
    C,F,H--75776300(+) TTTATC/TGTTAT 1 -- int16Minor allele frequency- T:0.06NS EA CSA WA 535
    rs1931468181,2
    --75776387(+) GTGAAA/GCATCT 1 -- int10--------
    rs1444164561,2
    --75776540(+) CATACC/GAAGCA 1 -- int10--------
    rs105214511,2
    C,F,H--75776652(+) TTACCA/CATGTT 1 -- int117Minor allele frequency- C:0.08NS NA EA WA 898
    rs1848712161,2
    --75776658(+) ATGTTC/TATGTT 1 -- int10--------
    rs1892889041,2
    --75776662(+) TTATGC/TTAGAT 1 -- int10--------
    rs27951171,2
    C,F,O,A,H--75776681(+) CAGTGA/GTAATA 1 -- int116Minor allele frequency- G:0.44NS EA NA WA 928
    rs1487148161,2
    --75776719(+) ATAGTG/TTATAA 1 -- int10--------
    rs1816780001,2
    --75776732(+) ATAAGC/TGTTTA 1 -- int10--------
    rs1844127701,2
    --75776808(+) TTTTAA/GTCCGT 1 -- int10--------
    rs1888126331,2
    --75776812(+) AGTCCA/GTTTGT 1 -- int10--------
    rs1422520741,2
    --75776869(+) AAATAC/TTGTAC 1 -- int10--------
    rs1812192141,2
    --75777086(+) ATCTCA/CCAACA 1 -- int10--------
    rs1467884581,2
    --75777250(+) ACACAG/TAAATC 1 -- int10--------
    rs1405870101,2
    --75777313(+) TTTGCA/GTTCAA 1 -- int10--------
    rs111435101,2
    C,F,H--75777381(+) TCTGCC/TATGTT 1 -- int17Minor allele frequency- T:0.09NS EA WA NA 778
    rs625415531,2
    C--75777421(+) CTATAC/TAATTT 1 -- int14Minor allele frequency- T:0.12NA WA EA 360
    rs1157984621,2
    F--75777435(+) CTTAAC/TGAAAG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1861443661,2
    --75777462(+) TTTCAA/GTCACA 1 -- int10--------
    rs1909986351,2
    C--75777764(+) TTTGCT/CTTCTC 2 /P /L mis11Minor allele frequency- C:0.00EU 1321
    rs734916481,2
    C--75777818(+) TTATAG/AAGACT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs601703151,2
    C,F--75778193(+) GGGATC/TAAATT 1 -- int12Minor allele frequency- T:0.04WA 120
    rs1862653461,2
    --75778199(+) AAATTC/TCAACA 1 -- int10--------
    rs1138839881,2
    C--75778218(+) GGAGGG/CGAAGA 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs132937461,2
    C,F,H--75778238(+) ACCATC/TGCAAG 1 -- int119Minor allele frequency- T:0.19NS EA NA CSA WA 2226
    rs412778911,2
    F--75778243(+) CGCAAG/ATAAAA 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1160463911,2
    F--75778291(+) ATACCT/CTTTTC 1 -- int11Minor allele frequency- C:0.03WA 118
    rs27951181,2
    C,F,O,H--75778370(+) CTTACA/GATAGA 1 -- int1100Minor allele frequency- G:0.05NS EA NA PA EU CA WA 7467
    rs1153625051,2
    C,F--75778451(+) AGGGTA/GAGGAA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1461193281,2
    C--75778584(+) AATGA-/GGCATG 1 -- int10--------
    rs1907797021,2
    --75778624(+) TAGTCG/TTTGTA 1 -- int10--------
    rs1829366711,2
    --75778717(+) TTGTTA/TGTTAA 1 -- int10--------
    rs1873051691,2
    --75778740(+) CCTTTC/TGTTGT 1 -- int10--------
    rs1912874761,2
    --75778856(+) GTCAAC/TTTATA 1 -- int10--------
    rs1443104181,2
    C--75778896(+) AAGAGA/TATAGG 1 -- int10--------
    rs1464815101,2
    --75778917(+) ATAATA/TTATGC 1 -- int10--------
    rs1832562711,2
    --75779184(+) TAATAC/GGCACT 1 -- int10--------
    rs1877304521,2
    --75779295(+) AAATTA/GTTCAA 1 -- int10--------
    rs768136611,2
    F--75779339(+) ATTGCC/TCATAA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1927213531,2
    --75779415(+) TTAATA/GTATAT 1 -- int10--------
    rs1410378391,2
    --75779463(+) TGATGA/GTAGTC 1 -- int10--------
    rs1836893891,2
    --75779566(+) TTGATA/CTATTT 1 -- int10--------
    rs1879663921,2
    --75779580(+) TAAGAA/TTATGC 1 -- int10--------
    rs803554871,2
    F--75779637(+) TCAAAA/TTGCAA 1 -- int11Minor allele frequency- T:0.02NA 120
    rs785366061,2
    C--75779718(+) TAAAAA/CATCTT 1 -- int15Minor allele frequency- C:0.14NA WA EA 362
    rs1501660891,2
    --75779754(+) CTATAC/GAGCAT 1 -- int10--------
    rs413061571,2
    C,F--75779917(+) CTACTC/TTGATT 1 -- int11Minor allele frequency- T:0.02NA 120
    rs734916521,2
    C,F--75779958(+) TCTTTG/AACAAG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1490332551,2
    C,F--75780055(+) GAAAGG/AAGAAA 2 /R syn12Minor allele frequency- A:0.00NA EU 5873
    rs3702329101,2
    C--75780070(+) ACAGAA/C/TGTAAA 3 E D mis1 syn10--------
    rs1446431431,2
    C--75780087(+) CAATAC/ACATCC 2 /N /T mis11Minor allele frequency- A:0.00NA 4552
    rs1846440301,2
    C--75780105(+) CAGAAA/GCTATC 2 N S mis10--------
    rs2007955281,2
    --75780125(+) GCAGAC/GGTAAC 2 L V mis10--------
    rs2003193411,2
    --75780144(+) TCTTTA/TTCTGG 1 -- int10--------
    rs170585631,2
    C,F,H--75780149(+) TTCTGG/CAATCT 1 -- int19Minor allele frequency- C:0.01NA NS EA 682
    rs1489047481,2
    --75780216(+) AACCCG/TTTTTC 1 -- int10--------
    rs111435111,2
    C,F,H--75780251(+) TACAGT/CGTTCC 1 -- int16Minor allele frequency- C:0.04NS EA WA 538
    rs777875871,2
    C,F--75780385(+) AAAAGA/GTTTGG 1 -- int12Minor allele frequency- G:0.14CSA WA 120
    rs801759541,2
    F--75780407(+) GAAAAG/AACATG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs757496171,2
    C,F--75780434(+) AAATTA/GGAATG 1 -- int14Minor allele frequency- G:0.09CSA WA 123
    rs123360531,2
    A--75780461(+) AAAAAA/CCAAAA 1 -- int1 trp30--------
    rs1151939211,2
    F--75780484(+) TAAATG/TAAGAA 1 -- int11Minor allele frequency- T:0.05WA 118
    rs625438681,2
    C,F--75780532(+) CAAAAC/TTCAGA 1 -- int12Minor allele frequency- T:0.05NA 122
    rs783688171,2
    C,F--75780699(+) TAAGGG/AAAGAT 1 -- int11Minor allele frequency- A:0.03NA 120
    rs27951191,2
    C,F,A,H--75780714(+) TTGCTG/ATGGCT 1 -- int119Minor allele frequency- A:0.20NS EA WA NA 2342
    rs1171649621,2
    F--75780715(+) TGCTGT/AGGCTC 1 -- int11Minor allele frequency- A:0.02EA 120
    rs1434196201,2
    --75780760(+) TCACAG/TGCCGT 1 -- int10--------
    rs1140685441,2
    F--75780931(+) TTCTTT/CGAGTC 1 -- int11Minor allele frequency- C:0.04WA 118
    rs1462510701,2
    C--75781035(+) AAGTAC/TAGTAA 2 Y syn11Minor allele frequency- T:0.00NA 4534
    rs1121856781,2
    C--75781109(+) TATCGG/TTATGT 1 -- spd10--------
    rs1114987121,2
    C--75781110(+) ATCGGG/TATGTA 1 -- spd10--------
    rs1435111801,2
    C--75781144(+) TAACTA/GGAAAT 1 -- int10--------
    rs788642701,2
    C,F--75781234(+) TAGTGC/AATCTG 1 -- int11Minor allele frequency- A:0.01EA 120
    rs105120151,2
    C,F,H--75781246(+) TTCAAT/CTGAAG 1 -- int127Minor allele frequency- C:0.13NS NA EA WA 2588
    rs1814367831,2
    --75781255(+) AGCAAC/TGTAAA 1 -- int10--------
    rs27951201,2
    C,F,H--75781376(+) CAGGCT/GGGGCA 1 -- int19Minor allele frequency- G:0.18NS EA NA WA 782
    rs734916601,2
    C--75781436(+) AAATGC/TAACAT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1849271671,2
    --75781468(+) TCCTGC/GTCTAC 1 -- int10--------
    rs774737831,2
    C,F--75781473(+) GTCTAC/TTGCTT 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1458981231,2
    --75781475(+) CTACTA/GCTTGT 1 -- int10--------
    rs1893798631,2
    --75781483(+) TGTTAA/CTTGTA 1 -- int10--------
    rs1384758491,2
    --75781541(+) GCCTCC/TAAAAA 1 -- int10--------
    rs1809236961,2
    --75781564(+) AAAGAA/TCTCCC 1 -- int10--------
    rs1419693251,2
    --75781663(+) AGCTTG/TTTAAA 1 -- int10--------
    rs1506695601,2
    --75781721(+) TTTCTA/GACAAG 1 -- int10--------
    rs1849403621,2
    --75781734(+) CCCCAC/TTGATG 1 -- int10--------
    rs123425221,2
    C,F,H--75781745(+) ccaatG/Tctgtt 1 -- int14Minor allele frequency- T:0.01NS EA 420
    rs27951211,2
    C,F,H--75781764(+) gatcTC/TGACAA 1 -- int14Minor allele frequency- T:0.01NS EA 420
    rs1480371621,2
    C--75781994(+) CCAAT-/GCCCCT 1 -- int10--------
    rs13420181,2
    C,F,O,A,H--75782131(-) TATTCT/CCCTTG 1 -- int124Minor allele frequency- C:0.25NS EA NA CSA WA 2472
    rs123395331,2
    C,F,H--75782168(+) GTTGCT/CCTTGA 1 -- int14Minor allele frequency- C:0.01NS EA 420
    rs1910239731,2
    --75782358(+) ATATGA/GATATT 1 -- int10--------
    rs2021422511,2
    --75782386(+) AATACA/CTCAAC 1 -- int10--------
    rs1418100711,2
    C,F--75782421(+) AGTGCG/ACCACA 2 /T /A mis12Minor allele frequency- A:0.00NA EU 5853
    rs1505914471,2
    C,F--75782445(+) TCTTTG/TCAGAG 2 A S mis11Minor allele frequency- T:0.00NA 4530
    rs2008438941,2
    --75782447(+) TTTGCA/CGAGAA 2 A syn10--------
    rs1818024571,2
    C--75782481(+) GTACCA/GTTCTA 1 -- int10--------
    rs13420171,2
    C,F,A,H--75782510(-) TAATTC/TTTCCT 1 -- int1 trp335Minor allele frequency- T:0.43NS EA NA WA CSA 3332
    rs170585701,2
    C,F,H--75782555(+) AAAATC/GTCACA 1 -- int113Minor allele frequency- G:0.02NA NS EA 1522
    rs19812881,2
    C,F,O,A,H--75782655(-) AAAAAA/GGCACC 1 -- int128Minor allele frequency- G:0.36NS EA NA WA CSA 3946
    rs734916661,2
    C--75782700(+) ATTTAC/TGGCTC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs795810731,2
    C--75782738(+) ACCACG/AGGAAG 1 -- int13Minor allele frequency- A:0.08CSA WA 121
    rs28112241,2
    C,F,H--75782864(+) TTATGC/TCACAG 1 -- int16Minor allele frequency- T:0.02NS EA WA 540
    rs1168332611,2
    F--75782912(+) TAAGGA/GTGTAG 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1148869481,2
    F--75782926(+) GATGTA/TTTTGA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1860385871,2
    --75782963(+) TGTCTC/GACATG 1 -- int10--------
    rs1917929681,2
    --75783060(+) CAGCTC/TCAAAA 1 -- int10--------
    rs1832526101,2
    --75783066(+) CAAAAC/TAAGGA 1 -- int10--------
    rs781484251,2
    F--75783083(+) CAGAGA/GGAGAG 1 -- int11Minor allele frequency- G:0.01WA 118
    rs106960941,2
    C--75783091(+) AGAGA-/AAG/GA
            
    AAGAA
    2 -- int1 cds1 trp30--------
    rs1395502511,2
    --75783106(+) CTAACC/TATTTG 1 -- int10--------
    rs1442684631,2
    --75783118(+) ATAATA/GTGAAG 1 -- int10--------
    rs101196051,2
    C,F,H--75783255(+) GTAATG/CATGAA 1 -- int14Minor allele frequency- C:0.01NS EA 420
    rs1866574411,2
    --75783345(+) TAACAC/TCTGAA 1 -- int10--------
    rs1486619311,2
    --75783440(+) ACACAC/TAGGCT 1 -- int10--------
    rs746172991,2
    F--75783463(+) GTAACA/GTAACC 1 -- int11Minor allele frequency- G:0.04WA 118
    rs1421437641,2
    --75783506(+) ACACTA/GGAAGA 1 -- int10--------
    rs105771901,2
    C--75783797(+) GTAAG-/GTGTGTG 1 -- int10--------
    rs38326431,2
    C--75783828(+) TGTGT-/GT/GT 
    GTGTGTGT
    ATAGC
    1 -- int11NA 2
    rs764840111,2
    F--75783840(+) AGTTTC/TTCTAT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs37399591,2
    C,F,A,H--75783937(+) CATTTA/GTTTTG 1 -- int130Minor allele frequency- G:0.41EA NA NS WA CSA EU 5395
    rs13922