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ANXA1 Gene

protein-coding   GIFtS: 71
GCID: GC09P075766

Annexin A1


(Previous symbols: ANX1, LPC1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Annexin A11 2     annexin-12
LPC11 2 3 5     calpactin-22
ANX11 2 3     chromobindin-92
Calpactin II2 3     Annexin-13
Lipocortin I2 3     Calpactin-23
Phospholipase A2 Inhibitory Protein2 3     Chromobindin-93
p352 3     Annexin I3
Annexin I (Lipocortin I)2     

External Ids:    HGNC: 5331   Entrez Gene: 3012   Ensembl: ENSG000001350467   OMIM: 1516905   UniProtKB: P040833   

Export aliases for ANXA1 gene to outside databases

Previous GC identifers: GC09P066811 GC09P067623 GC09P069336 GC09P071223 GC09P072996 GC09P074956 GC09P045589


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANXA1 Gene:
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of
approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane.
Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity.
Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins
and leukotrienes, annexin I may have potential anti-inflammatory activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for ANXA1 Gene:
ANXA1 (annexin A1) is a protein-coding gene. Diseases associated with ANXA1 include brain edema, and colon adenocarcinoma. GO annotations related to this gene include phospholipid binding and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Gene Wiki entry for ANXA1 (Annexin A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANXA1 gene promoter:
         C/EBPbeta   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   AREB6   POU2F1   POU2F1a   STAT3   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ANXA1 promoter sequence
   Search Chromatin IP Primers for ANXA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANXA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q21.13

ANXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P075766:  view genomic region     (about GC identifiers)

Start:
75,766,673 bp from pter      End:
75,785,309 bp from pter
Size:
18,637 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083 (See protein sequence)
Recommended Name: Annexin A1  
Size: 346 amino acids; 38714 Da
Subunit: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity)
3 PDB 3D structures from and Proteopedia for ANXA1:
1AIN (3D)        1BO9 (3D)        1QLS (3D)    

Explore the universe of human proteins at neXtProt for ANXA1: NX_P04083

Explore proteomics data for ANXA1 at MOPED

Post-translational modifications: 

  • Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in
    loss of the inhibitory activity1
  • Ubiquitination2 at Lys58, Lys166, Lys274
  • Glycosylation2 at Ser37
  • Modification sites at PhosphoSitePlus

  • See ANXA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000691.1  
    ENSEMBL proteins: 
     ENSP00000257497   ENSP00000412489   ENSP00000414013   ENSP00000366109  
    Reactome Protein details: P04083

    ANXA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for ANXA1
    OriGene Protein Over-expression Lysate for ANXA1
    OriGene MassSpec for ANXA1
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    GenScript Custom Purified and Recombinant Proteins Services for ANXA1
    Novus Biologicals ANXA1 Proteins
    Novus Biologicals ANXA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ANXA1
    Cloud-Clone Corp. Proteins for ANXA1

    ANXA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANXA1
    R&D Systems Antibodies for ANXA1 (Annexin A1)
    Cell Signaling Technology (CST) Antibodies for ANXA1 
    OriGene Antibodies for ANXA1
    OriGene Custom Antibody Services for ANXA1
    Novus Biologicals ANXA1 Antibodies
    Abcam antibodies for ANXA1
    Cloud-Clone Corp. Antibodies for ANXA1
    ThermoFisher Antibody for ANXA1
    LSBio Antibodies in human, mouse, rat for ANXA1

    ANXA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ANXA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ANXA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ANXA1
    Cloud-Clone Corp. CLIAs for ANXA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    ANXA: Annexins

    4 InterPro protein domains:
     IPR018502 Annexin_repeat
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR002388 AnnexinI

    Graphical View of Domain Structure for InterPro Entry P04083

    ProtoNet protein and cluster: P04083

    2 Blocks protein domains:
    IPB001464 Annexin
    IPB002388 Annexin type I signature


    UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    ANXA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANXA1_HUMAN, P04083
    Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
    protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

         Genatlas biochemistry entry for ANXA1:
    annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of
    the organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid
    feadback action in the hypothalamo-hypophysial system

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity ----
    GO:0005102receptor binding TAS10882119
    GO:0005198structural molecule activity IDA10908733
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
         
    ANXA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ANXA1:
     Decreased viability 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Anxa1):
     adipose tissue  cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     nervous system  skeleton  tumorigenesis 

    ANXA1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANXA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANXA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANXA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANXA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANXA1:
    hsa-mir-30a-5p (MIRT028650), hsa-mir-335-5p (MIRT018638), hsa-mir-26b-5p (MIRT030065), hsa-mir-196a-5p (MIRT000709)

    Block miRNA regulation of human, mouse, rat ANXA1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ANXA1
    SwitchGear 3'UTR luciferase reporter plasmidANXA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANXA1
    Predesigned siRNA for gene silencing in human, mouse, rat ANXA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ANXA1

    Clone
    Products:
         
    OriGene clones in human, mouse for ANXA1 (see all 6)
    OriGene ORF clones in mouse, rat for ANXA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANXA1 (NM_000700)
    Sino Biological Human cDNA Clone for ANXA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ANXA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ANXA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANXA1_HUMAN, P04083: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity).
    Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of
    ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and
    alveolar macrophages (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular5
    cytosol4
    plasma membrane4
    endosome2
    mitochondrion2
    nucleus2
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001533cornified envelope IDA10908733
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS16130169

    ANXA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANXA1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Formyl peptide receptors bind formyl peptides and many other ligands0.00
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Spinal Cord Injury
    Spinal Cord Injury
    5Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ANXA1
        Ca, cAMP and Lipid Signaling

    4 BioSystems Pathways for ANXA1
        Integrated Breast Cancer Pathway
    Spinal Cord Injury
    Prostaglandin Synthesis and Regulation
    Integrated Pancreatic Cancer Pathway


    3 Reactome Pathways for ANXA1
        Formyl peptide receptors bind formyl peptides and many other ligands
    G alpha (q) signalling events
    G alpha (i) signalling events



    ANXA1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ANXA1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANXA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANXA1 (P040831, 2, 3 ENSP000002574974) via UniProtKB, MINT, STRING, and/or I2D (see all 310) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBB1O002132, 3, ENSP000002994024MINT-8247707 I2D: score=2 STRING: ENSP00000299402
    ENSG00000272333Q9UMN62, 3MINT-8247832 I2D: score=2 
    KMT2BQ9UMN62, 3MINT-8247832 I2D: score=2 
    C14orf1Q9UKR52, 3MINT-8247720 I2D: score=2 
    CCT7Q998322, 3MINT-8247753 I2D: score=2 
    COPS6Q7L5N12, 3MINT-8247764 I2D: score=2 
    CSADQ9Y6002, 3MINT-8247775 I2D: score=2 
    FAF1Q9UNN52, 3MINT-8247786 I2D: score=2 
    GAPDHP044062, 3MINT-8247797 I2D: score=2 
    KLHL23Q8NBE82, 3MINT-8247808 I2D: score=2 
    LRIF1Q5T3J32, 3MINT-8247731 I2D: score=2 
    OTUB1Q96FW12, 3MINT-8247844 I2D: score=2 
    RPA1P276942, 3MINT-8247855 I2D: score=2 
    UBE2D1P516682, 3MINT-8247866 I2D: score=2 
    UNC119Q134322, 3MINT-8247877 I2D: score=2 
    XRCC6P129562, 3MINT-8247888 I2D: score=2 
    EGFRP005332, 3, ENSP000002754934MINT-51101 MINT-51102 I2D: score=4 STRING: ENSP00000275493
    SLX1AQ9BQ833, ENSP000002513034I2D: score=2 STRING: ENSP00000251303
    IKBKGQ9Y6K91, 3, ENSP000003586224EBI-354007,EBI-81279 I2D: score=1 STRING: ENSP00000358622
    RIPK1Q135461, 3, ENSP000002598084EBI-354007,EBI-358507 I2D: score=1 STRING: ENSP00000259808
    SLX1BQ9BQ833, ENSP000003289404I2D: score=2 STRING: ENSP00000328940
    C1orf123Q9NWV42, 3, ENSP000002943604MINT-8247742 I2D: score=2 STRING: ENSP00000294360
    YWHAZP631042, 3, ENSP000003095034MINT-3297886 I2D: score=1 STRING: ENSP00000309503
    DYSFO759233, ENSP000003868814I2D: score=3 STRING: ENSP00000386881
    ATG4BQ9Y4P13, ENSP000003842594I2D: score=2 STRING: ENSP00000384259
    DLG3Q927963, ENSP000003634804I2D: score=2 STRING: ENSP00000363480
    PPM1BO756883, ENSP000002824124I2D: score=2 STRING: ENSP00000282412
    SQSTM1Q135013, ENSP000003744554I2D: score=2 STRING: ENSP00000374455
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    FPR1P214623, ENSP000003027074I2D: score=1 STRING: ENSP00000302707
    UBE2IP632793, ENSP000003248974I2D: score=1 STRING: ENSP00000324897
    UBE3AQ050863, ENSP000003810454I2D: score=1 STRING: ENSP00000381045
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    S100A11P319493, ENSP000002716384I2D: score=3 STRING: ENSP00000271638
    USP25Q9UHP33, ENSP000002856794I2D: score=2 STRING: ENSP00000285679
    USPL1Q5W0Q73, ENSP000002553044I2D: score=2 STRING: ENSP00000255304
    KRT8P057873, ENSP000002933084I2D: score=3 STRING: ENSP00000293308
    PRKCIP417433, ENSP000002957974I2D: score=1 STRING: ENSP00000295797
    SRCP129313, ENSP000003509414I2D: score=2 STRING: ENSP00000350941
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    TGM2P219803, ENSP000003553304I2D: score=2 STRING: ENSP00000355330
    TRPM7Q96QT43, ENSP000003202394I2D: score=1 STRING: ENSP00000320239
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    SUMO2P619563, ENSP000004059654I2D: score=1 STRING: ENSP00000405965
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    NFKBIAP259633, ENSP000002167974I2D: score=1 STRING: ENSP00000216797
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    CD4P017303, ENSP000000116534I2D: score=1 STRING: ENSP00000011653
    APCP250543I2D: score=1 
    ATG101Q9BSB43I2D: score=1 
    CSF1P096033I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    NSMAFQ926363I2D: score=1 
    PDPK1O155303I2D: score=1 
    PLA2G4AP477123I2D: score=1 
    SLC2A4P146723I2D: score=1 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY9ENSP000002940164STRING: ENSP00000294016
    ADRA1DENSP000003687664STRING: ENSP00000368766
    APPENSP000002849814STRING: ENSP00000284981
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    C3ENSP000002459074STRING: ENSP00000245907
    C5ENSP000002236424STRING: ENSP00000223642
    C5AR1ENSP000003471974STRING: ENSP00000347197
    CASRENSP000002961544STRING: ENSP00000296154
    CCKENSP000003356574STRING: ENSP00000335657
    CCL20ENSP000003516714STRING: ENSP00000351671
    CCL21ENSP000002596074STRING: ENSP00000259607
    CCL5ENSP000002932724STRING: ENSP00000293272
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR5ENSP000002923034STRING: ENSP00000292303
    CCR7ENSP000002466574STRING: ENSP00000246657
    CXCL1ENSP000003791104STRING: ENSP00000379110
    CXCL13ENSP000002867584STRING: ENSP00000286758
    CXCL3ENSP000002960264STRING: ENSP00000296026
    CXCL5ENSP000002960274STRING: ENSP00000296027
    CXCL6ENSP000002263174STRING: ENSP00000226317
    CXCR2ENSP000003196354STRING: ENSP00000319635
    CYSLTR2ENSP000002820184STRING: ENSP00000282018
    EDN1ENSP000003686834STRING: ENSP00000368683
    EDN2ENSP000003616684STRING: ENSP00000361668
    EDNRAENSP000003150114STRING: ENSP00000315011
    EDNRBENSP000003353114STRING: ENSP00000335311
    F2RENSP000003213264STRING: ENSP00000321326
    F2RL1ENSP000002966774STRING: ENSP00000296677
    FPR2ENSP000003401914STRING: ENSP00000340191
    FPR3ENSP000003418214STRING: ENSP00000341821
    GALENSP000002656434STRING: ENSP00000265643
    GCGENSP000003876624STRING: ENSP00000387662
    GCGRENSP000003835584STRING: ENSP00000383558
    GNA15ENSP000002629584STRING: ENSP00000262958
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GNRH1ENSP000002764144STRING: ENSP00000276414
    GNRHRENSP000002264134STRING: ENSP00000226413
    GPR18ENSP000003434284STRING: ENSP00000343428
    GRPENSP000002568574STRING: ENSP00000256857
    HTR2BENSP000002584004STRING: ENSP00000258400
    KNG1ENSP000002650234STRING: ENSP00000265023
    LTB4RENSP000003074454STRING: ENSP00000307445
    MTNR1AENSP000003028114STRING: ENSP00000302811
    MTNR1BENSP000002570684STRING: ENSP00000257068
    NMUENSP000002642184STRING: ENSP00000264218
    NPYENSP000002421524STRING: ENSP00000242152
    P2RY2ENSP000003103054STRING: ENSP00000310305
    PIK3CAENSP000002639674STRING: ENSP00000263967
    PIK3R1ENSP000002743354STRING: ENSP00000274335
    PLCB2ENSP000002604024STRING: ENSP00000260402
    POMCENSP000002647084STRING: ENSP00000264708
    PTAFRENSP000003019744STRING: ENSP00000301974
    PTGDR2ENSP000003328124STRING: ENSP00000332812
    PTGER3ENSP000003490034STRING: ENSP00000349003
    RGS1ENSP000003564294STRING: ENSP00000356429
    RGS19ENSP000003331944STRING: ENSP00000333194
    RGS2ENSP000002353824STRING: ENSP00000235382
    SSTENSP000002876414STRING: ENSP00000287641
    TAC1ENSP000003211064STRING: ENSP00000321106
    TRHENSP000003034524STRING: ENSP00000303452
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY6ENSP000003114054STRING: ENSP00000311405
    ADCY7ENSP000002542354STRING: ENSP00000254235
    ADCY8ENSP000002863554STRING: ENSP00000286355
    ADORA1ENSP000003085494STRING: ENSP00000308549
    ADORA3ENSP000003587304STRING: ENSP00000358730
    ADRA1BENSP000003066624STRING: ENSP00000306662
    ADRA2AENSP000002801554STRING: ENSP00000280155
    ADRA2BENSP000003872814STRING: ENSP00000387281
    ADRA2CENSP000003860694STRING: ENSP00000386069
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    AGTR1ENSP000002734304STRING: ENSP00000273430
    AGTR2ENSP000003609734STRING: ENSP00000360973
    APLNENSP000003054644STRING: ENSP00000305464
    APLNRENSP000002572544STRING: ENSP00000257254
    ARHGEF25ENSP000003355604STRING: ENSP00000335560
    AVPR1AENSP000002991784STRING: ENSP00000299178
    AVPR1BENSP000003560944STRING: ENSP00000356094
    BDKRB1ENSP000002166294STRING: ENSP00000216629
    C3AR1ENSP000003020794STRING: ENSP00000302079
    CCKARENSP000002955894STRING: ENSP00000295589
    CCKBRENSP000003355444STRING: ENSP00000335544
    CCL16ENSP000002932754STRING: ENSP00000293275
    CCL19ENSP000003088154STRING: ENSP00000308815
    CCL25ENSP000003750864STRING: ENSP00000375086
    CCL27ENSP000002596314STRING: ENSP00000259631
    CCL28ENSP000003544164STRING: ENSP00000354416
    CCR3ENSP000003500034STRING: ENSP00000350003
    CCR6ENSP000003393934STRING: ENSP00000339393
    CCR8ENSP000003264324STRING: ENSP00000326432
    CHRM1ENSP000003064904STRING: ENSP00000306490
    CHRM2ENSP000003199844STRING: ENSP00000319984
    CHRM3ENSP000002553804STRING: ENSP00000255380
    CHRM4ENSP000004093784STRING: ENSP00000409378
    CIDEBENSP000003377314STRING: ENSP00000337731
    CXCL10ENSP000003056514STRING: ENSP00000305651
    CXCL11ENSP000003068844STRING: ENSP00000306884
    CXCL16ENSP000002937784STRING: ENSP00000293778
    CXCL9ENSP000003549014STRING: ENSP00000354901
    CXCR1ENSP000002956834STRING: ENSP00000295683
    CXCR5ENSP000002921744STRING: ENSP00000292174
    CXCR6ENSP000003044144STRING: ENSP00000304414
    CYSLTR1ENSP000003624014STRING: ENSP00000362401
    DRD2ENSP000003548594STRING: ENSP00000354859
    DRD3ENSP000003731694STRING: ENSP00000373169
    DRD4ENSP000001761834STRING: ENSP00000176183
    EDN3ENSP000003371284STRING: ENSP00000337128
    F2RL2ENSP000002966414STRING: ENSP00000296641
    F2RL3ENSP000002480764STRING: ENSP00000248076
    FFAR1ENSP000002465534STRING: ENSP00000246553
    FFAR2ENSP000002465494STRING: ENSP00000246549
    GALR1ENSP000002997274STRING: ENSP00000299727
    GALR2ENSP000003296844STRING: ENSP00000329684
    GALR3ENSP000002490414STRING: ENSP00000249041
    GASTENSP000003313584STRING: ENSP00000331358
    GHSRENSP000002412564STRING: ENSP00000241256
    GNA14ENSP000003658074STRING: ENSP00000365807
    GNG2ENSP000003344484STRING: ENSP00000334448
    GNRH2ENSP000002459834STRING: ENSP00000245983
    GPER1ENSP000002974694STRING: ENSP00000297469
    GPR132ENSP000003288184STRING: ENSP00000328818
    GPR17ENSP000002726444STRING: ENSP00000272644
    GPR4ENSP000003197444STRING: ENSP00000319744
    GPR55ENSP000003758934STRING: ENSP00000375893
    GPR65ENSP000002675494STRING: ENSP00000267549
    GPR68ENSP000002386994STRING: ENSP00000238699
    GPRC6AENSP000003094934STRING: ENSP00000309493
    GRK5ENSP000003766094STRING: ENSP00000376609
    GRPRENSP000003696434STRING: ENSP00000369643
    HCAR2ENSP000003750664STRING: ENSP00000375066
    HCRTENSP000002933304STRING: ENSP00000293330
    HCRTR1ENSP000003628104STRING: ENSP00000362810
    HEBP1ENSP000000149304STRING: ENSP00000014930
    HRH3ENSP000003425604STRING: ENSP00000342560
    HRH4ENSP000002569064STRING: ENSP00000256906
    HTR1AENSP000003162444STRING: ENSP00000316244
    HTR1BENSP000003589634STRING: ENSP00000358963
    HTR1DENSP000003136614STRING: ENSP00000313661
    HTR1EENSP000003077664STRING: ENSP00000307766
    HTR1FENSP000003229244STRING: ENSP00000322924
    HTR2AENSP000003679594STRING: ENSP00000367959
    HTR2CENSP000002761984STRING: ENSP00000276198
    HTR5AENSP000002879074STRING: ENSP00000287907
    KISS1ENSP000003561624STRING: ENSP00000356162
    KISS1RENSP000002343714STRING: ENSP00000234371
    LPAR1ENSP000003517554STRING: ENSP00000351755
    LPAR2ENSP000003846654STRING: ENSP00000384665
    LPAR3ENSP000003596434STRING: ENSP00000359643
    LPAR6ENSP000003443534STRING: ENSP00000344353
    MCHR1ENSP000002490164STRING: ENSP00000249016
    MCHR2ENSP000002818064STRING: ENSP00000281806
    MLNENSP000002660034STRING: ENSP00000266003
    MLNRENSP000002187214STRING: ENSP00000218721
    NMBRENSP000002580424STRING: ENSP00000258042
    NMSENSP000003660614STRING: ENSP00000366061
    NMUR1ENSP000003058774STRING: ENSP00000305877
    NMUR2ENSP000002552624STRING: ENSP00000255262
    NPBENSP000003327664STRING: ENSP00000332766
    NPBWR1ENSP000003302844STRING: ENSP00000330284
    NPBWR2ENSP000003587834STRING: ENSP00000358783
    NPFFENSP000002670174STRING: ENSP00000267017
    NPFFR1ENSP000002779424STRING: ENSP00000277942
    NPFFR2ENSP000003078224STRING: ENSP00000307822
    NPSENSP000003811054STRING: ENSP00000381105
    NPSR1ENSP000003528394STRING: ENSP00000352839
    NPWENSP000003300704STRING: ENSP00000330070
    NPY1RENSP000003546524STRING: ENSP00000354652
    NPY2RENSP000003325914STRING: ENSP00000332591
    NPY4RENSP000003634314STRING: ENSP00000363431
    NPY5RENSP000003393774STRING: ENSP00000339377
    NTSENSP000002560104STRING: ENSP00000256010
    NTSR1ENSP000003595324STRING: ENSP00000359532
    NTSR2ENSP000003036864STRING: ENSP00000303686
    OPN4ENSP000003611414STRING: ENSP00000361141
    OPRD1ENSP000002349614STRING: ENSP00000234961
    OPRK1ENSP000002655724STRING: ENSP00000265572
    OPRL1ENSP000003367644STRING: ENSP00000336764
    OPRM1ENSP000003946244STRING: ENSP00000394624
    OXER1ENSP000003679304STRING: ENSP00000367930
    OXTENSP000002173864STRING: ENSP00000217386
    OXTRENSP000003242704STRING: ENSP00000324270
    P2RY1ENSP000003047674STRING: ENSP00000304767
    P2RY10ENSP000001717574STRING: ENSP00000171757
    P2RY12ENSP000003072594STRING: ENSP00000307259
    P2RY13ENSP000003203764STRING: ENSP00000320376
    P2RY14ENSP000003083614STRING: ENSP00000308361
    P2RY4ENSP000003636434STRING: ENSP00000363643
    P2RY6ENSP000003097714STRING: ENSP00000309771
    PDYNENSP000002173054STRING: ENSP00000217305
    PENKENSP000003242484STRING: ENSP00000324248
    PIK3R2ENSP000002222544STRING: ENSP00000222254
    PIK3R3ENSP000002627414STRING: ENSP00000262741
    PLCB1ENSP000003381854STRING: ENSP00000338185
    PLCB3ENSP000002792304STRING: ENSP00000279230
    PLCB4ENSP000003341054STRING: ENSP00000334105
    PMCHENSP000003322254STRING: ENSP00000332225
    PNOCENSP000003019084STRING: ENSP00000301908
    PPBPENSP000002960284STRING: ENSP00000296028
    PPYENSP000002259924STRING: ENSP00000225992
    PROK1ENSP000002713314STRING: ENSP00000271331
    PROK2ENSP000002956194STRING: ENSP00000295619
    PROKR1ENSP000003037754STRING: ENSP00000303775
    PROKR2ENSP000002172704STRING: ENSP00000217270
    PTGER1ENSP000002925134STRING: ENSP00000292513
    PTGFRENSP000003597934STRING: ENSP00000359793
    PYYENSP000003531984STRING: ENSP00000353198
    QRFPENSP000003454874STRING: ENSP00000345487
    QRFPRENSP000003356104STRING: ENSP00000335610
    RGS10ENSP000003580994STRING: ENSP00000358099
    RGS14ENSP000003862294STRING: ENSP00000386229
    RGS18ENSP000003564304STRING: ENSP00000356430
    RGS20ENSP000002973134STRING: ENSP00000297313
    RGS4ENSP000003971814STRING: ENSP00000397181
    RGS6ENSP000003839534STRING: ENSP00000383953
    RGS7ENSP000003555204STRING: ENSP00000355520
    RXFP3ENSP000003287084STRING: ENSP00000328708
    RXFP4ENSP000003573014STRING: ENSP00000357301
    S1PR1ENSP000003054164STRING: ENSP00000305416
    S1PR3ENSP000003508784STRING: ENSP00000350878
    S1PR4ENSP000002461154STRING: ENSP00000246115
    S1PR5ENSP000003284724STRING: ENSP00000328472
    SSTR1ENSP000002673774STRING: ENSP00000267377
    SSTR2ENSP000003501984STRING: ENSP00000350198
    SSTR3ENSP000003301384STRING: ENSP00000330138
    SSTR4ENSP000002550084STRING: ENSP00000255008
    SSTR5ENSP000002938974STRING: ENSP00000293897
    TAC3ENSP000003001084STRING: ENSP00000300108
    TACR1ENSP000003035224STRING: ENSP00000303522
    TACR2ENSP000003624034STRING: ENSP00000362403
    TACR3ENSP000003033254STRING: ENSP00000303325
    TBXA2RENSP000003643364STRING: ENSP00000364336
    TRHRENSP000003098184STRING: ENSP00000309818
    UTS2ENSP000000546684STRING: ENSP00000054668
    UTS2BENSP000003405264STRING: ENSP00000340526
    UTS2RENSP000003235164STRING: ENSP00000323516
    XCR1ENSP000003104054STRING: ENSP00000310405
    USP21ENSP000002898654STRING: ENSP00000289865
    ANXA5ENSP000002965114STRING: ENSP00000296511
    HMGA1ENSP000003082274STRING: ENSP00000308227
    MGMTENSP000003021114STRING: ENSP00000302111
    ATF2ENSP000002641104STRING: ENSP00000264110
    ABCG2ENSP000002376124STRING: ENSP00000237612
    KNCNENSP000003796074STRING: ENSP00000379607
    SIRT7ENSP000003294664STRING: ENSP00000329466
    --B4DEE83I2D: score=1 
    --ENSP000002644924STRING: ENSP00000264492
    --ENSP000003623984STRING: ENSP00000362398
    --ENSP000003545694STRING: ENSP00000354569
    --ENSP000003311084STRING: ENSP00000331108
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001780neutrophil homeostasis IMP--
    GO:0002674negative regulation of acute inflammatory response IEA--
    GO:0006928cellular component movement TAS10882119
    GO:0006954inflammatory response TAS10882119
    GO:0007049cell cycle ----

    ANXA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ANXA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ThiolutinBacterial RNA polymerase inhibitor[87-11-6]
    Heparin sodium saltAnticoagulant[9041-08-1]
    Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor[154303-05-6]
    RGDS peptideIntegrin binding sequence; inhibits integrin receptor function[91037-65-9]
    Ac2-26Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation[151988-33-9]

    1 HMDB Compound for ANXA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for ANXA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Hydrocortisone11beta-Hydroxycortisone (see all 16)50-23-7targetagonist1712816 17139284 11142771 17016423 8060156
    DexamethasoneDesametasone (see all 9)50-02-2targetagonist17644190 17076770 17158208 16883066
    Amcinonide-- 51022-69-6targetagonist17139284 17016423 7981624

    Selected Novoseek inferred chemical compound relationships for ANXA1 gene (see all 56)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hdmnkvldl 84.9 2 8818992 (1), 1793057 (1)
    phosphatidylserine 62.1 29 8179621 (3), 7627125 (1), 12744815 (1), 15381697 (1) (see all 16)
    phospholipid 59.7 33 8379935 (7), 2138536 (1), 1310621 (1), 8485141 (1) (see all 20)
    calcium 55 126 11142771 (6), 9299392 (5), 18283055 (4), 1469069 (3) (see all 58)
    arachidonic acid 49.2 16 2064175 (2), 8260938 (2), 2137129 (2), 12845669 (1) (see all 10)
    dexamethasone 45.3 54 8256657 (6), 12236584 (5), 17644190 (4), 14668092 (3) (see all 17)
    glyceraldehyde 3-phosphate 44.7 7 16220529 (1), 17268060 (1), 15274135 (1), 19899082 (1) (see all 7)
    geneticin 32.2 1 7764687 (1)
    phosphatidylcholine 30.4 17 16307464 (2), 12845669 (1), 7654693 (1), 1387325 (1) (see all 5)
    p-opc 30 7 16307464 (3), 18237543 (2)



    ANXA1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for ANXA1 gene: 
    NM_000700.1  

    Unigene Cluster for ANXA1:

    Annexin A1
    Hs.494173  [show with all ESTs]
    Unigene Representative Sequence: AK074480
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257497(uc004ajf.1) ENST00000468639 ENST00000456643 ENST00000415424
    ENST00000376911(uc004ajg.1) ENST00000495713 ENST00000489109 ENST00000491192


    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANXA1
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    OriGene ORF clones in mouse, rat for ANXA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANXA1 (NM_000700)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA1
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    OriGene qPCR primer pairs and template standards for ANXA1
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      QuantiTect SYBR Green Assays in human, mouse, rat ANXA1
      QuantiFast Probe-based Assays in human, mouse, rat ANXA1

    Additional mRNA sequence: 

    AB451274.1 AB451401.1 AK023330.1 AK074480.1 AK296808.1 AK311684.1 BC001275.1 BC018683.1 
    BC034157.1 BC035993.1 BT019896.1 BT019916.1 BT019917.1 CR407684.1 X05908.1 

    Selected DOTS entries (see all 49):

    DT.95080391  DT.100890399  DT.95202652  DT.100765659  DT.100890413  DT.100890422  DT.100890394  DT.100890395 
    DT.121161786  DT.100890415  DT.95340497  DT.95223581  DT.92045136  DT.92466092  DT.100040129  DT.100890410 
    DT.100890409  DT.91793108  DT.91703452  DT.91949347  DT.121161854  DT.100890404  DT.92466082  DT.92466099 

    Selected AceView cDNA sequences (see all 1569):

    CD709026 BG748968 CA419768 CA414702 CB159233 CB134078 CB409715 AW439690 
    CB147659 BM762676 BQ228510 BE163625 AA360576 CB134806 AU137564 BQ962052 
    BQ775829 CA405627 BQ962446 CA443862 AU137423 AU135495 BM476344 BU684426 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:              -     -     -     -     -                 -           -                 -                             -                 -                     
    SP2:                                                        -           -                 -                             -                 -                     
    SP3:              -           -     -     -                 -           -                 -                             -                                       
    SP4:                                                                                      -                             -                                       
    SP5:                    -     -     -     -                 -           -                 -                                                                     


    ECgene alternative splicing isoforms for ANXA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ANXA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAAGATGT
    ANXA1 Expression
    About this image


    ANXA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 34) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             Line H9 (Naive)
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Cerebral Cortex
             Dorsal forebrain-like neurons
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Laryngeal Cartilage
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocytes Zeugopod Epiphyseal End
             Bone Marrow
    ANXA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANXA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.494173
        Pathway & Disease-focused RT2 Profiler PCR Array including ANXA1: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for ANXA1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anxa11 , 5 annexin A11, 5 86.61(n)1
    87.57(a)1
      19 (13.83 cM)5
    169521  NM_010730.21  NP_034860.21 
     203734285 
    chicken
    (Gallus gallus)
    Aves ANXA11 annexin A1 75.07(n)
    78.59(a)
      404271  NM_206906.1  NP_996789.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA16
    annexin A1
    76(a)
    1 ↔ 1
    2(47804835-47822960)
    African clawed frog
    (Xenopus laevis)
    Amphibia anxa1-prov2 annexin A1 77.96(n)    BC053786.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anxa1a2 annexin A1a 73.36(n)   334724  AY178793.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nex-23 Annexin 42(a)
    (best of 3)
      III(10397630-10399688)   --


    ENSEMBL Gene Tree for ANXA1 (if available)
    TreeFam Gene Tree for ANXA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for ANXA1 gene
    ANXA32  ANXA62  ANXA52  ANXA92  ANXA22  ANXA72  ANXA82  ANXA112  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA1 using alignment to 6 protein entries:     ANXA1_HUMAN (see all proteins):
    ANXA2    ANXA2P2    DKFZp686H02120    ANXA13    ANXA7    ANXA8
    ANXA11    ANXA3    ANXA4    ANXA5    ANXA8L2    ANXA6
    ANXA8L1    ANXA9    ANXA10

    ANXA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ANXA1 (see all 449)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127652951,2
    C,F--75764783(+) TAGTGG/ACTTTC 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs23103121,2
    C,F,O,A,H--75764998(+) CAAAGC/AAAAAT 1 -- us2k124Minor allele frequency- A:0.19NA NS EA WA 2694
    rs1390908591,2
    --75765039(+) TTTTAC/TAAAAA 1 -- us2k10--------
    rs1423959281,2
    --75765093(+) AGGAAA/TGTTCC 1 -- us2k10--------
    rs37583551,2
    C,F,H--75765100(+) TTCCAA/GTAGTT 1 -- us2k15Minor allele frequency- G:0.02EA NS 1898
    rs1929154221,2
    --75765212(+) TATTAA/GAAAGT 1 -- us2k10--------
    rs785905931,2
    C--75765229(+) ACATCT/CGTCAA 1 -- us2k13Minor allele frequency- C:0.08CSA WA 121
    rs1851810361,2
    --75765234(+) TGTCAA/GGATCA 1 -- us2k10--------
    rs339429881,2
    C--75765264(+) ACTTA-/ACTTGT 1 -- us2k10--------
    rs1170381621,2
    F--75765351(+) GATTAG/CATGAT 1 -- us2k11Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for ANXA1 (75766673 - 75785309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ANXA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6561CNV Insertion18451855
    nsv526225CNV Gain19592680
    nsv519796CNV Gain19592680
    nsv893452CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151690    OMIM disorders: --

    Selected diseases for ANXA1 (see all 75):    
    About MalaCards
    brain edema    colon adenocarcinoma    oral cancer    uterine fibroid
    prostate adenocarcinoma    hairy cell leukemia    sarcoidosis    pulmonary sarcoidosis
    lung adenocarcinoma    psoriatic arthritis    stomach cancer    oral squamous cell carcinoma
    endocarditis    idiopathic pulmonary fibrosis    laryngeal squamous cell carcinoma    cystic fibrosis
    esophageal squamous cell carcinoma    pulmonary fibrosis    adenocarcinoma    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for ANXA1:
    Carcinoma

    ANXA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ANXA1 gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 41.2 25 15447985 (3), 12242662 (2), 18297688 (2), 12679902 (2) (see all 17)
    adenocarcinoma lung 38.7 5 17351649 (2), 17974280 (1)
    inflammation 32.3 33 9796991 (3), 15962097 (3), 19104500 (2), 9831319 (1) (see all 21)
    premalignant 27 6 10448305 (1), 19351789 (1), 19101730 (1), 14695321 (1)
    tumors 24.8 58 16270603 (4), 19173988 (3), 17340616 (3), 18652761 (3) (see all 29)
    prostatic intraepithelial neoplasia 23.9 4 16324197 (2), 11801547 (1)
    colon adenocarcinoma 23.9 6 15526283 (3), 18541673 (2)
    oral cancer 21.1 6 18297688 (2), 20371204 (1), 12870656 (1)
    cancer 16.7 34 18663355 (4), 20215502 (2), 16324197 (2), 20371204 (1) (see all 15)
    metastasis 16.6 22 18535914 (3), 20353277 (3), 18776816 (3), 18223218 (2) (see all 11)

    Genetic Association Database (GAD): ANXA1
    Human Genome Epidemiology (HuGE) Navigator: ANXA1 (6 documents)

    Export disorders for ANXA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANXA1 gene, integrated from 10 sources (see all 550):
    (articles sorted by number of sources associating them with ANXA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PubMed id 2936963)1, 2, 3 Wallner B.P.... Pepinsky R.B. (Nature 1986)
    2. Crystal structure of human annexin I at 2.5-A resolution. (PubMed id 8453382)1, 2, 9 Weng X.... Huber R. (Protein Sci. 1993)
    3. Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PubMed id 16883066)1, 7, 9 Morand E.F....Yang Y.H. (Mediators Inflamm. 2006)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Phosphorylation of annexin I by TRPM7 channel-kinase. (PubMed id 15485879)1, 2 Dorovkov M.V. and Ryazanov A.G. (J. Biol. Chem. 2004)
    6. [Absence of evidence for the association of single nucleotide polymorphisms in Annexin A1 gene with type 2 diabetes in Chinese]. (PubMed id 15476183)1, 4 Dong Y....Luo M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Characterization of the annexin I gene and evaluation of its role in type 2 diabetes. (PubMed id 11574426)1, 4 Lindgren C.M....Groop L.C. (Diabetes 2001)
    9. NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit. (PubMed id 9915835)1, 2 Gao J.... Yan H. (J. Biol. Chem. 1999)
    10. Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. (PubMed id 8425544)1, 2 Arcone R.... Ciliberto G. (Eur. J. Biochem. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 301 HGNC: 533 AceView: ANXA1 Ensembl:ENSG00000135046 euGenes: HUgn301
    ECgene: ANXA1 H-InvDB: ANXA1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ANXA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANXA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ANXA1 gene:
    Search GeneIP for patents involving ANXA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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