Aliases for ANXA1 Gene
Aliases for ANXA1 Gene
External Ids for ANXA1 Gene
- HGNC: 533
- Entrez Gene: 301
- Ensembl: ENSG00000135046
- OMIM: 151690
- UniProtKB: P04083
Previous HGNC Symbols for ANXA1 Gene
- ANX1
- LPC1
Previous GeneCards Identifiers for ANXA1 Gene
- GC09P066811
- GC09P067623
- GC09P069336
- GC09P071223
- GC09P072996
- GC09P074956
- GC09P075766
- GC09P045589
Summaries for ANXA1 Gene
-
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
GeneCards Summary for ANXA1 Gene
ANXA1 (Annexin A1) is a Protein Coding gene. Diseases associated with ANXA1 include Hairy Cell Leukemia and Rheumatoid Arthritis. Among its related pathways are Cardiac conduction and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include calcium ion binding and receptor binding. An important paralog of this gene is ANXA2.
UniProtKB/Swiss-Prot for ANXA1 Gene
-
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
-
Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.
Additional gene information for ANXA1 Gene
- Monarch Initiative
- Search for ANXA1 at DataMed
- Search for ANXA1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA1 Gene
Genomics for ANXA1 Gene
GeneHancer (GH) Regulatory Elements for ANXA1 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH09I073147 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 562.8 | +0.7 | 712 | 9.6 | PKNOX1 SMAD1 ARNT ZFP64 SIN3A FEZF1 IRF4 POLR2B ZNF766 ZNF213 | ANXA1 GC09M073159 PIR62868 GC09M073140 | |
GH09I073117 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 16.2 | -33.0 | -32997 | 2.3 | NFIB JUN MAX CEBPG RFX5 FOSL1 FOSL2 NFE2 FOS NFE2L2 | ANXA1 ALDH1A1 GC09P073115 GC09P073141 | |
GH09I073115 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE dbSUPER | 15.7 | -35.5 | -35488 | 0.8 | JUNB MAFG BATF ZNF316 JUND MAFF EMSY MAFK | GC09P073115 ANXA1 ALDH1A1 GC09P073141 | |
GH09I072359 | Promoter/Enhancer | 2.5 | EPDnew Ensembl ENCODE dbSUPER | 4.3 | -788.7 | -788656 | 7.9 | HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 | ZFAND5 TMC1 LINC01504 ANXA1 GC09P072358 | |
GH09I073125 | Enhancer | 0.5 | ENCODE dbSUPER | 19.5 | -25.9 | -25891 | 0.2 | ZNF664 | ANXA1 GC09P073115 GC09P073141 |
- Top Transcription factor binding sites by QIAGEN in the ANXA1 gene promoter:
Regulatory Element Products
Genomic Locations for ANXA1 Gene
- chr9:73,151,731-73,170,393
- (GRCh38/hg38)
- Size:
- 18,663 bases
- Orientation:
- Plus strand
- chr9:75,766,673-75,785,309
- (GRCh37/hg19)
Genomic View for ANXA1 Gene
- Cytogenetic band:
-
- 9q21.13 by Ensembl
- 9q21.13 by Entrez Gene
- 9q21.13 by HGNC


RefSeq DNA sequence for ANXA1 Gene
Proteins for ANXA1 Gene
-
Protein details for ANXA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04083-ANXA1_HUMAN
- Recommended name:
- Annexin A1
- Protein Accession:
- P04083
Protein attributes for ANXA1 Gene
- Size:
- 346 amino acids
- Molecular mass:
- 38714 Da
- Quaternary structure:
-
- Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation (PubMed:2532504). Homodimers linked by transglutamylation are observed in placenta, but not in other tissues (PubMed:2532504). Interacts with S100A11 (PubMed:8557678, PubMed:10673436). Heterotetramer, formed by two molecules each of S100A11 and ANXA1 (PubMed:10673436). Interacts with DYSF (By similarity). Interacts with EGFR (By similarity).
- Miscellaneous:
-
- Was originally identified as calcium and phospholipid binding protein that displays Ca(2+)-dependent binding to phospholipid membranes and can promote membrane aggregation in vitro. Was initially identified as inhibitor of phospholipase A2 activity (in vitro) (PubMed:2936963, PubMed:8425544). Inhibition of phospholipase activity is mediated via its phospholipid binding activity that limits the access of phospholipase to its substrates.
Protein Expression for ANXA1 Gene
Post-translational modifications for ANXA1 Gene
- Phosphorylated by protein kinase C, EGFR and TRPM7 (PubMed:2457390, PubMed:15485879). Phosphorylated in response to EGF treatment (PubMed:2532504).
- Sumoylated.
- Ubiquitination at Lys58, posLast=166166, and posLast=274274
Other Protein References for ANXA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ANXA1 (Annexin A1)
- Cell Signaling Technology (CST) Antibodies for ANXA1 (ANXA1)
- Novus Biologicals Antibodies for ANXA1
-
Abcam antibodies for ANXA1
-
Cloud-Clone Corp. Antibodies for ANXA1
- Invitrogen Antibodies for ANXA1
- antibodies-online: Search results for 379 available Annexin a1 Antibodies ranked by validation data
- Compare Top Annexin a1 Antibodies
-
Recommended
- 249 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 RIA Antibody (anti-human)
- 92 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 71 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex ANXA1 antibody for ANXA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ANXA1
Protein Products
- R&D Systems Proteins and Enzymes for ANXA1 (Annexin A1)
-
OriGene Purified Proteins for ANXA1
- Search Origene for MassSpec and Protein Over-expression Lysates for ANXA1
- Origene Custom Protein Services for ANXA1
- ProSpec Recombinant Proteins for ANXA1
-
Cloud-Clone Corp. Proteins for ANXA1
- Search GeneTex for Proteins for ANXA1
-
ProSci Proteins for ANXA1
-
Abcam proteins for ANXA1
Assay Products
-
Abcam assays for ANXA1
No data available for DME Specific Peptides for ANXA1 Gene
Domains & Families for ANXA1 Gene
Gene Families for ANXA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Transporters
Protein Domains for ANXA1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANXA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P04083UniProtKB/Swiss-Prot:
ANXA1_HUMAN :- The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
- Belongs to the annexin family.
- Domain:
-
- The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
- The N-terminal 26 amino acids are sufficient for its extracellular functions in the regulation of inflammation and wound healing (PubMed:25664854). Acylated peptides that contain the first 26 amino acids of the mature protein can activate signaling via the formyl peptide receptors (PubMed:15187149, PubMed:25664854).
- Family:
-
- Belongs to the annexin family.
Function for ANXA1 Gene
Molecular function for ANXA1 Gene
- GENATLAS Biochemistry:
- annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of the organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid feadback action in the hypothalamo-hypophysial system
- UniProtKB/Swiss-Prot Function:
- Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
Phenotypes From GWAS Catalog for ANXA1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003697 | single-stranded DNA binding | IEA | -- |
GO:0003727 | single-stranded RNA binding | IEA | -- |
GO:0004386 | helicase activity | IEA | -- |
GO:0004859 | phospholipase inhibitor activity | IEA | -- |
GO:0005102 | receptor binding | TAS | 10882119 |
Phenotypes for ANXA1 Gene
- MGI mutant phenotypes for ANXA1:
-
inferred from 1 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- hematopoietic system phenotype
- skeleton phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for ANXA1:
Animal Models for ANXA1 Gene
- MGI Knock Outs for ANXA1:
-
- Anxa1 tm1Rjf
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANXA1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANXA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANXA1 gene
- Search ViGene Biosciences for ANXA1
CRISPR Products
-
OriGene CRISPR knockouts for ANXA1
- genomics-online: gRNA clones - Search results for 149 available Annexin a1 gene related products
- Overview of 149 available Annexin a1 gene related products
- Applied Biological Materials CRISPR for ANXA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANXA1
- GenScript: Design CRISPR guide RNA sequences for ANXA1
miRNA for ANXA1 Gene
- miRTarBase miRNAs that target ANXA1
miRNA Products
- Search ViGene Biosciences for ANXA1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for ANXA1
- Browse OriGene Inhibitory RNA Products For ANXA1
- genomics-online: shRNA clones - Search results for 149 available Annexin a1 gene related products
- Overview of 149 available Annexin a1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ANXA1 gene
Clone Products
- Sino Biological Human cDNA Clone for ANXA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANXA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANXA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ANXA1
- Applied Biological Materials Clones for ANXA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ANXA1
-
ViGene Biosciences adenoviral particle packaged cDNA for ANXA1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANXA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANXA1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANXA1 Gene
Localization for ANXA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANXA1 Gene
- Nucleus. Cytoplasm. Cell projection, cilium. Cell membrane. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Basolateral cell membrane. Apical cell membrane. Lateral cell membrane. Secreted. Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted, exosome. Cytoplasmic vesicle, secretory vesicle lumen. Cell projection, phagocytic cup. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). {ECO:0000250 UniProtKB:P10107, ECO:0000269 PubMed:10772777, ECO:0000269 PubMed:17008549, ECO:0000269 PubMed:2532504, ECO:0000269 PubMed:25664854, ECO:0000269 PubMed:8557678}.
- Cytosol (4)
- Nucleoplasm (4)
- Plasma membrane (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001533 | cornified envelope | IDA | 10908733 |
GO:0001891 | phagocytic cup | IEA | -- |
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IDA,IEA | 17008549 |
GO:0005634 | nucleus | IEA,IDA | 22056994 |
Pathways & Interactions for ANXA1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | Cytokine Signaling in Immune system | ||
4 | RET signaling | ||
5 | Ca, cAMP and Lipid Signaling |
Pathways by source for ANXA1 Gene
1 Cell Signaling Technology pathway for ANXA1 Gene
3 BioSystems pathways for ANXA1 Gene
Interacting Proteins for ANXA1 Gene
SIGNOR curated interactions for ANXA1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000733 | DNA strand renaturation | IEA | -- |
GO:0001780 | neutrophil homeostasis | IMP,IEA | 21957127 |
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002548 | monocyte chemotaxis | IDA | 15187149 |
Drugs & Compounds for ANXA1 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Agonist, Target, agonist | 2314 | ||
Amcinonide | Approved | Pharma | Target, agonist | 0 | ||
Hydrocortisone | Approved, Vet_approved | Pharma | Agonist, Target, agonist | 713 | ||
Prednisolone | Approved, Vet_approved | Pharma | Agonist, binder | 1277 | ||
calcium | Approved | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Ac2-26 |
|
151988-33-9 |
|
|
||
Heparin sodium salt |
|
9041-08-1 |
|
|
(5) Tocris Compounds for ANXA1 Gene
Compound | Action | Cas Number |
---|---|---|
Ac2-12 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 256447-08-2 |
Ac2-26 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 151988-33-9 |
Heparin sodium salt | Anticoagulant | 9041-08-1 |
KF 38789 | Selective inhibitor of P-selectin-mediated cell adhesion | 257292-29-8 |
PM 102 | Antagonist of heparin (Cat. No. 2812) | 1234564-95-4 |
(1) ApexBio Compounds for ANXA1 Gene
Compound | Action | Cas Number |
---|---|---|
Thiolutin | RNA polymerase inhibitor,antibiotic | 1987-11-6 |
Transcripts for ANXA1 Gene
mRNA/cDNA for ANXA1 Gene
- (3) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (1569) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ANXA1
- genomics-online: gRNA clones - Search results for 149 available Annexin a1 gene related products
- Overview of 149 available Annexin a1 gene related products
- Applied Biological Materials CRISPR for ANXA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANXA1
- GenScript: Design CRISPR guide RNA sequences for ANXA1
miRNA Products
- Search ViGene Biosciences for ANXA1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for ANXA1
- Browse OriGene Inhibitory RNA Products For ANXA1
- genomics-online: shRNA clones - Search results for 149 available Annexin a1 gene related products
- Overview of 149 available Annexin a1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ANXA1 gene
Clone Products
- Sino Biological Human cDNA Clone for ANXA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANXA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANXA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ANXA1
- Applied Biological Materials Clones for ANXA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
Expression for ANXA1 Gene
mRNA differential expression in normal tissues according to GTEx for ANXA1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANXA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANXA1 Gene:
ANXA1SOURCE GeneReport for Unigene cluster for ANXA1 Gene:
Hs.494173mRNA Expression by UniProt/SwissProt for ANXA1 Gene:
P04083-ANXA1_HUMANEvidence on tissue expression from TISSUES for ANXA1 Gene
- Liver(4.9)
- Lung(4.9)
- Nervous system(4.4)
- Bone(4)
- Skin(3.6)
- Stomach(3.6)
- Blood(3.4)
- Thyroid gland(3.4)
- Bone marrow(3.3)
- Intestine(3.3)
- Heart(3.2)
- Spleen(2.8)
- Kidney(2.6)
- Muscle(2.5)
- Adrenal gland(2.4)
- Gall bladder(2.4)
- Lymph node(2.4)
- Pancreas(2.3)
- Eye(2)
Primer Products
-
OriGene qPCR primer pairs for ANXA1
-
OriGene qPCR primer pairs and template standards for ANXA1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA1 Gene
Orthologs for ANXA1 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ANXA1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | ANXA1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | ANXA1 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Anxa1 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Anxa1 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | ANXA1 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | ANXA1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | ANXA1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | ANXA1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | anxa1 33 |
|
||
MGC76270 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | anxa1-prov 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | anxa1a 33 34 |
|
||
ANXA1 (4 of 4) 34 |
|
OneToMany | |||
anxa1b 34 |
|
OneToMany | |||
anxa1c 34 |
|
OneToMany | |||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8605 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | AnnIX 35 |
|
|
|
worm (Caenorhabditis elegans) |
Secernentea | nex-2 35 |
|
|
|
nex-1 35 34 |
|
||||
nex-3 35 34 |
|
||||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany |
- Species where no ortholog for ANXA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ANXA1 Gene
Paralogs for ANXA1 Gene
(15) SIMAP similar genes for ANXA1 Gene using alignment to 6 proteins:
Variants for ANXA1 Gene
SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000241754 | -- | 73,170,167(+) | A/G | 3_prime_UTR_variant | |
rs1000266047 | -- | 73,154,568(+) | A/G | 5_prime_UTR_variant, intron_variant | |
rs1000373649 | -- | 73,153,274(+) | A/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000594415 | -- | 73,153,045(+) | A/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000754947 | -- | 73,166,252(+) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3620660 | CNV | loss | 21293372 |
esv3620661 | CNV | gain | 21293372 |
esv3620662 | CNV | gain | 21293372 |
nsv526225 | CNV | gain | 19592680 |
nsv614612 | CNV | gain | 21841781 |
nsv6561 | CNV | insertion | 18451855 |
nsv951528 | CNV | duplication | 24416366 |
Additional Variant Information for ANXA1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA1 Gene
Disorders for ANXA1 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
hairy cell leukemia |
|
|
rheumatoid arthritis |
|
|
lung cancer susceptibility 3 |
|
|
breast cancer |
|
|
esophageal cancer |
|
|
Additional Disease Information for ANXA1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA1 Gene
Publications for ANXA1 Gene
- Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PMID: 16883066) Morand EF … Yang YH (Mediators of inflammation 2006) 3 22 25 58
- Calcium-dependent binding of S100C to the N-terminal domain of annexin I. (PMID: 8557678) Mailliard WS … Schlaepfer DD (The Journal of biological chemistry 1996) 3 4 22 58
- Crystal structure of human annexin I at 2.5 A resolution. (PMID: 8453382) Weng X … Huber R (Protein science : a publication of the Protein Society 1993) 3 4 22 58
- Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PMID: 2936963) Wallner BP … Ramachandran KL (Nature 1986) 2 3 4 58
- Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. (PMID: 25664854) Leoni G … Nusrat A (The Journal of clinical investigation 2015) 3 4 58
Products for ANXA1 Gene
- R&D Systems Antibodies for ANXA1 (Annexin A1)
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- Browse Primary Antibodies
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- Invitrogen Antibodies for ANXA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for ANXA1
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANXA1
- VectorBuilder custom plasmid, inducible vectors for ANXA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANXA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ANXA1
- antibodies-online: Search results for 379 available Annexin a1 Antibodies ranked by validation data
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- 249 WB Antibodies (anti-human)
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- 2 IF Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 RIA Antibody (anti-human)
- 92 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 71 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 46 available Annexin a1 Elisa Kits ranked by validation data
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- GeneTex ANXA1 antibody for ANXA1
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- ViGene Biosciences adenoviral particle packaged cDNA for ANXA1 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for ANXA1
- Search Santa Cruz Biotechnology (SCBT) for ANXA1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ANXA1
- Search for ANXA1 Antibodies at ProSci
- Custom Antibody Services
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- Horizon Cell Lines for ANXA1
- genomics-online: cdna clones - Search results for 149 available Annexin a1 gene related products
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Sources for ANXA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
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- (128) ViGene Biosciences
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- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew