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ANXA1 Gene

protein-coding GIFtS: 71
GCID: GC09P075766

Annexin A1

(Previous symbols: ANX1, LPC1)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Annexin A1¹ ²		annexin-1²
LPC1¹ ² ³ ⁵		calpactin-2²
ANX1¹ ² ³		chromobindin-9²
Calpactin II² ³		Annexin-1³
Lipocortin I² ³		Calpactin-2³
Phospholipase A2 Inhibitory Protein² ³		Chromobindin-9³
p35² ³		Annexin I³
Annexin I (Lipocortin I)²

External Ids:	HGNC: 533¹	Entrez Gene: 301²	Ensembl: ENSG00000135046⁷	OMIM: 151690⁵	UniProtKB: P04083³

Export aliases for ANXA1 gene to outside databases

Previous GC identifers: GC09P066811 GC09P067623 GC09P069336 GC09P071223 GC09P072996 GC09P074956 GC09P045589

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANXA1 Gene:

Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of

approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane.

Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity.

Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins

and leukotrienes, annexin I may have potential anti-inflammatory activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for ANXA1 Gene:

ANXA1 (annexin A1) is a protein-coding gene. Diseases associated with ANXA1 include brain edema, and colon adenocarcinoma. GO annotations related to this gene include phospholipid binding and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083

Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This

protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Gene Wiki entry for ANXA1 (Annexin A1) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000009.12 NC_018920.2 NT_008470.20

Regulatory elements:

Regulatory transcription factor binding sites in the ANXA1 gene promoter:
C/EBPbeta POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 C/EBPalpha AREB6 POU2F1 POU2F1a STAT3 TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ANXA1 promoter sequence

Search Chromatin IP Primers for ANXA1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANXA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13 Ensembl cytogenetic band: 9q21.13 HGNC cytogenetic band: 9q21.13

ANXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P075766: view genomic region (about GC identifiers)

Start:	75,766,673 bp from pter	End:	75,785,309 bp from pter
Size:	18,637 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083 (See protein sequence)

Recommended Name: Annexin A1

Size: 346 amino acids; 38714 Da

Subunit: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity)

3 PDB 3D structures from and Proteopedia for ANXA1:

1AIN (3D)

1BO9 (3D)

1QLS (3D)

Explore the universe of human proteins at neXtProt for ANXA1: NX_P04083

Explore proteomics data for ANXA1 at MOPED

Post-translational modifications:

Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in

loss of the inhibitory activity¹

Ubiquitination² at Lys58, Lys166, Lys274

Glycosylation² at Ser37

Modification sites at PhosphoSitePlus

See ANXA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000691.1

ENSEMBL proteins:

ENSP00000257497 ENSP00000412489 ENSP00000414013 ENSP00000366109

Reactome Protein details: P04083

ANXA1 Human Recombinant Protein Products:

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	OriGene Purified Protein for ANXA1 OriGene Protein Over-expression Lysate for ANXA1 OriGene MassSpec for ANXA1 OriGene Custom Protein Services for ANXA1
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	Novus Biologicals ANXA1 Proteins Novus Biologicals ANXA1 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for ANXA1
	Cloud-Clone Corp. Proteins for ANXA1

ANXA1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ANXA1
	R&D Systems Antibodies for ANXA1 (Annexin A1)
	Cell Signaling Technology (CST) Antibodies for ANXA1
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	Novus Biologicals ANXA1 Antibodies
	Abcam antibodies for ANXA1
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	LSBio Antibodies in human, mouse, rat for ANXA1

ANXA1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for ANXA1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ANXA1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for ANXA1 Cloud-Clone Corp. CLIAs for ANXA1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ENDOLIG: Endogenous ligands

ANXA: Annexins

4 InterPro protein domains:

IPR018502 Annexin_repeat

IPR001464 Annexin

IPR018252 Annexin_repeat_CS

IPR002388 AnnexinI

Graphical View of Domain Structure for InterPro Entry P04083

ProtoNet protein and cluster: P04083

2 Blocks protein domains:

IPB001464 Annexin

IPB002388 Annexin type I signature

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083

Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid

Similarity: Belongs to the annexin family

Similarity: Contains 4 annexin repeats

ANXA1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ANXA1_HUMAN, P04083

Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This

protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Genatlas biochemistry entry for ANXA1:

annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of

the organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid

feadback action in the hypothalamo-hypophysial system

Gene Ontology (GO): Selected molecular function terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004859	phospholipase inhibitor activity	--	--
GO:0005102	receptor binding	TAS	10882119
GO:0005198	structural molecule activity	IDA	10908733
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	--

ANXA1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ANXA1:

Decreased viability

13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Anxa1):

adipose tissue	cardiovascular system	craniofacial	digestive/alimentary	endocrine/exocrine gland
growth/size/body	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
nervous system	skeleton	tumorigenesis

ANXA1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANXA1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANXA1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANXA1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANXA1

miRNA Products:		miRTarBase miRNAs that target ANXA1: hsa-mir-30a-5p (MIRT028650), hsa-mir-335-5p (MIRT018638), hsa-mir-26b-5p (MIRT030065), hsa-mir-196a-5p (MIRT000709)

		Block miRNA regulation of human, mouse, rat ANXA1 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate ANXA1
		SwitchGear 3'UTR luciferase reporter plasmid: ANXA1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ANXA1
		Predesigned siRNA for gene silencing in human, mouse, rat ANXA1

Gene Editing
Products:

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Clone Products:		OriGene clones in human, mouse for ANXA1 (see all 6) OriGene ORF clones in mouse, rat for ANXA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ANXA1 (NM_000700)
		Sino Biological Human cDNA Clone for ANXA1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ANXA1
		Browse ESI BIO Cell Lines and PureStem Progenitors for ANXA1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

ANXA1_HUMAN, P04083: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity).

Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of

ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and

alveolar macrophages (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
extracellular	5
cytosol	4
plasma membrane	4
endosome	2
mitochondrion	2
nucleus	2
lysosome	1
vacuole	1

About this image

Gene Ontology (GO): 12 cellular component terms (see first 5): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001533	cornified envelope	IDA	10908733
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	16130169
GO:0005886	plasma membrane	IDA	--
GO:0005929	cilium	IEA	--
GO:0016323	basolateral plasma membrane	IEA	--
GO:0031966	mitochondrial membrane	IEA	--
GO:0042383	sarcolemma	IEA	--
GO:0043234	protein complex	IEA	--
GO:0070062	extracellular vesicular exosome	IDA	19056867

ANXA1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ANXA1 About (see all 10)

See pathways by source

SuperPath

Contained pathways About

Peptide ligand-binding receptors

Class A/1 (Rhodopsin-like receptors)	0.71	G alpha (i) signalling events	0.44
GPCR ligand binding	0.71	Formyl peptide receptors bind formyl peptides and many other ligands	0.00
Peptide ligand-binding receptors	0.60

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.58
	GPCR downstream signaling	0.90

Gastrin-CREB signalling pathway via PKC and MAPK

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

G alpha (q) signalling events

0.90

Spinal Cord Injury

Spinal Cord Injury

Selected targets of CREB1

Selected targets of CREB1

Pathways by source See SuperPaths
Show all pathways

1 Cell Signaling Technology (CST) Pathway for ANXA1

Ca, cAMP and Lipid Signaling

4 BioSystems Pathways for ANXA1

	Integrated Breast Cancer Pathway
	Spinal Cord Injury
	Prostaglandin Synthesis and Regulation
	Integrated Pancreatic Cancer Pathway

3 Reactome Pathways for ANXA1

	Formyl peptide receptors bind formyl peptides and many other ligands
	G alpha (q) signalling events
	G alpha (i) signalling events

ANXA1 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including ANXA1:

Apoptosis 384HT in human mouse rat

Interactions:

GeneGlobe Interaction Network for ANXA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ANXA1 (P04083^{1, 2, 3} ENSP00000257497⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 310)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APBB1	O00213²^,³, ENSP00000299402⁴	MINT-8247707 I2D: score=2 STRING: ENSP00000299402
ENSG00000272333	Q9UMN6²^,³	MINT-8247832 I2D: score=2
KMT2B	Q9UMN6²^,³	MINT-8247832 I2D: score=2
C14orf1	Q9UKR5²^,³	MINT-8247720 I2D: score=2
CCT7	Q99832²^,³	MINT-8247753 I2D: score=2

About this table

Gene Ontology (GO): Selected biological process terms (see all 37): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001780	neutrophil homeostasis	IMP	--
GO:0002674	negative regulation of acute inflammatory response	IEA	--
GO:0006928	cellular component movement	TAS	10882119
GO:0006954	inflammatory response	TAS	10882119
GO:0007049	cell cycle	--	--

ANXA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for ANXA1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Thiolutin	Bacterial RNA polymerase inhibitor	[87-11-6]
Heparin sodium salt	Anticoagulant	[9041-08-1]
Echistatin, alpha1 isoform	alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor	[154303-05-6]
RGDS peptide	Integrin binding sequence; inhibits integrin receptor function	[91037-65-9]
Ac2-26	Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation	[151988-33-9]

1 HMDB Compound for ANXA1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

3 DrugBank Compounds for ANXA1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Hydrocortisone	11beta-Hydroxycortisone (see all 16)	50-23-7	target	agonist	1712816 17139284 11142771 17016423 8060156
Dexamethasone	Desametasone (see all 9)	50-02-2	target	agonist	17644190 17076770 17158208 16883066
Amcinonide	--	51022-69-6	target	agonist	17139284 17016423 7981624

Selected Novoseek inferred chemical compound relationships for ANXA1 gene (see all 56) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hdmnkvldl	84.9	2	8818992 (1), 1793057 (1)
phosphatidylserine	62.1	29	8179621 (3), 7627125 (1), 12744815 (1), 15381697 (1) (see all 16)
phospholipid	59.7	33	8379935 (7), 2138536 (1), 1310621 (1), 8485141 (1) (see all 20)
calcium	55	126	11142771 (6), 9299392 (5), 18283055 (4), 1469069 (3) (see all 58)
arachidonic acid	49.2	16	2064175 (2), 8260938 (2), 2137129 (2), 12845669 (1) (see all 10)
dexamethasone	45.3	54	8256657 (6), 12236584 (5), 17644190 (4), 14668092 (3) (see all 17)
glyceraldehyde 3-phosphate	44.7	7	16220529 (1), 17268060 (1), 15274135 (1), 19899082 (1) (see all 7)
geneticin	32.2	1	7764687 (1)
phosphatidylcholine	30.4	17	16307464 (2), 12845669 (1), 7654693 (1), 1387325 (1) (see all 5)
p-opc	30	7	16307464 (3), 18237543 (2)

ANXA1 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ANXA1 gene:

NM_000700.1

Unigene Cluster for ANXA1:

Annexin A1

Hs.494173 [show with all ESTs]

Unigene Representative Sequence: AK074480

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000257497(uc004ajf.1) ENST00000468639 ENST00000456643 ENST00000415424

ENST00000376911(uc004ajg.1) ENST00000495713 ENST00000489109 ENST00000491192

miRNA Products:		Block miRNA regulation of human, mouse, rat ANXA1 using miScript Target Protectors
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		Predesigned siRNA for gene silencing in human, mouse, rat ANXA1

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		GenScript: all cDNA clones in your preferred vector: ANXA1 (NM_000700)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA1

Primer Products:		OriGene qPCR primer pairs and template standards for ANXA1 OriGene qSTAR qPCR primer pairs in human, mouse for ANXA1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ANXA1
		QuantiTect SYBR Green Assays in human, mouse, rat ANXA1
		QuantiFast Probe-based Assays in human, mouse, rat ANXA1

Additional mRNA sequence:

AB451274.1 AB451401.1 AK023330.1 AK074480.1 AK296808.1 AK311684.1 BC001275.1 BC018683.1

BC034157.1 BC035993.1 BT019896.1 BT019916.1 BT019917.1 CR407684.1 X05908.1

Selected DOTS entries (see all 49):

DT.95080391 DT.100890399 DT.95202652 DT.100765659 DT.100890413 DT.100890422 DT.100890394 DT.100890395

DT.121161786 DT.100890415 DT.95340497 DT.95223581 DT.92045136 DT.92466092 DT.100040129 DT.100890410

DT.100890409 DT.91793108 DT.91703452 DT.91949347 DT.121161854 DT.100890404 DT.92466082 DT.92466099

Selected AceView cDNA sequences (see all 1569):

CD709026 BG748968 CA419768 CA414702 CB159233 CB134078 CB409715 AW439690

CB147659 BM762676 BQ228510 BE163625 AA360576 CB134806 AU137564 BQ962052

BQ775829 CA405627 BQ962446 CA443862 AU137423 AU135495 BM476344 BU684426

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15a	·	15b
SP1:					-		-		-		-		-						-				-						-										-						-
SP2:																			-				-						-										-						-
SP3:					-				-		-		-						-				-						-										-
SP4:																													-										-
SP5:							-		-		-		-						-				-						-

ECgene alternative splicing isoforms for ANXA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ANXA1 expression in normal human tissues (normalized intensities) ANXA1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGAAAGATGT

About this image

ANXA1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 34) fully expand


Inner Cell Mass (Early Embryonic Tissues) fully expand to see all 5 entries
Line H9 (Naive)

Brain (Nervous System) fully expand to see all 4 entries
Adult Dopaminergic Neurons Substantia Nigra pars Compacta
Cerebral Cortex
Dorsal forebrain-like neurons

Cartilage (Muscoskeletal System) fully expand to see all 3 entries
Mesenchymal Condensate Cells Zeugopod
Laryngeal Cartilage

Fibroblasts
Cardiac Fibroblasts Myocardium
Detroit 551

Bone (Muscoskeletal System) fully expand to see all 3 entries
Chondrocytes Zeugopod Epiphyseal End
Bone Marrow

ANXA1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ANXA1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.494173

Pathway & Disease-focused RT² Profiler PCR Array including ANXA1:

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for ANXA1 OriGene qSTAR qPCR primer pairs in human, mouse for ANXA1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ANXA1
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		QuantiFast Probe-based Assays in human, mouse, rat ANXA1

In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ANXA1 gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Anxa1^{1 , 5}	annexin A1^{1, 5}	86.61(n)¹ 87.57(a)¹		19 (13.83 cM)⁵ 16952¹ NM_010730.2¹ NP_034860.2¹ 20373428⁵
chicken (Gallus gallus)	Aves	ANXA1¹	annexin A1	75.07(n) 78.59(a)		404271 NM_206906.1 NP_996789.1
lizard (Anolis carolinensis)	Reptilia	ANXA1⁶	annexin A1	76(a)	1 ↔ 1	2(47804835-47822960)
African clawed frog (Xenopus laevis)	Amphibia	anxa1-prov²	annexin A1	77.96(n)		BC053786.1
zebrafish (Danio rerio)	Actinopterygii	anxa1a²	annexin A1a	73.36(n)		334724 AY178793.1
worm (Caenorhabditis elegans)	Secernentea	nex-2³	Annexin	42(a) (best of 3)		III(10397630-10399688) --

ENSEMBL Gene Tree for ANXA1 (if available)
TreeFam Gene Tree for ANXA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ANXA1 gene

ANXA3² ANXA6² ANXA5² ANXA9² ANXA2² ANXA7² ANXA8² ANXA11²

ANXA8L2² ANXA10² ANXA8L1² ANXA4² ANXA13²

15 SIMAP similar genes for ANXA1 using alignment to 6 protein entries: ANXA1_HUMAN (see all proteins):

ANXA2 ANXA2P2 DKFZp686H02120 ANXA13 ANXA7 ANXA8

ANXA11 ANXA3 ANXA4 ANXA5 ANXA8L2 ANXA6

ANXA8L1 ANXA9 ANXA10

ANXA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112765295^1,2	C,F	--	75764783(+)	`TAGTGG/ACTTTC`	1	--	us2k¹		1		NA	120
rs2310312^1,2	C,F,O,A,H	--	75764998(+)	`CAAAGC/AAAAAT`	1	--	us2k¹		24		NA NS EA WA	2694
rs139090859^1,2		--	75765039(+)	`TTTTAC/TAAAAA`	1	--	us2k¹		0	--	--	--	--
rs142395928^1,2		--	75765093(+)	`AGGAAA/TGTTCC`	1	--	us2k¹		0	--	--	--	--
rs3758355^1,2	C,F,H	--	75765100(+)	`TTCCAA/GTAGTT`	1	--	us2k¹		5		EA NS	1898
rs192915422^1,2		--	75765212(+)	`TATTAA/GAAAGT`	1	--	us2k¹		0	--	--	--	--
rs78590593^1,2	C	--	75765229(+)	`ACATCT/CGTCAA`	1	--	us2k¹		3		CSA WA	121
rs185181036^1,2		--	75765234(+)	`TGTCAA/GGATCA`	1	--	us2k¹		0	--	--	--	--
rs33942988^1,2	C	--	75765264(+)	`ACTTA-/ACTTGT`	1	--	us2k¹		0	--	--	--	--
rs117038162^1,2	F	--	75765351(+)	`GATTAG/CATGAT`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for ANXA1 (75766673 - 75785309 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for ANXA1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv6561	CNV	Insertion	18451855
nsv526225	CNV	Gain	19592680
nsv519796	CNV	Gain	19592680
nsv893452	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 151690 OMIM disorders: --

Selected diseases for ANXA1 (see all 75): About MalaCards

brain edema colon adenocarcinoma oral cancer uterine fibroid

prostate adenocarcinoma hairy cell leukemia sarcoidosis pulmonary sarcoidosis

lung adenocarcinoma psoriatic arthritis stomach cancer oral squamous cell carcinoma

endocarditis idiopathic pulmonary fibrosis laryngeal squamous cell carcinoma cystic fibrosis

esophageal squamous cell carcinoma pulmonary fibrosis adenocarcinoma squamous cell carcinoma

1 disease from the University of Copenhagen DISEASES database for ANXA1:

Carcinoma

ANXA1 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for ANXA1 gene (see all 52) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell	41.2	25	15447985 (3), 12242662 (2), 18297688 (2), 12679902 (2) (see all 17)
adenocarcinoma lung	38.7	5	17351649 (2), 17974280 (1)
inflammation	32.3	33	9796991 (3), 15962097 (3), 19104500 (2), 9831319 (1) (see all 21)
premalignant	27	6	10448305 (1), 19351789 (1), 19101730 (1), 14695321 (1)
tumors	24.8	58	16270603 (4), 19173988 (3), 17340616 (3), 18652761 (3) (see all 29)
prostatic intraepithelial neoplasia	23.9	4	16324197 (2), 11801547 (1)
colon adenocarcinoma	23.9	6	15526283 (3), 18541673 (2)
oral cancer	21.1	6	18297688 (2), 20371204 (1), 12870656 (1)
cancer	16.7	34	18663355 (4), 20215502 (2), 16324197 (2), 20371204 (1) (see all 15)
metastasis	16.6	22	18535914 (3), 20353277 (3), 18776816 (3), 18223218 (2) (see all 11)

Genetic Association Database (GAD): ANXA1
Human Genome Epidemiology (HuGE) Navigator: ANXA1 (6 documents)

Export disorders for ANXA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ANXA1 gene, integrated from 10 sources (see all 550):
(articles sorted by number of sources associating them with ANXA1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PubMed id 2936963)^{1, 2, 3} Wallner B.P.... Pepinsky R.B. (Nature 1986)
Crystal structure of human annexin I at 2.5-A resolution. (PubMed id 8453382)^{1, 2, 9} Weng X.... Huber R. (Protein Sci. 1993)
Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PubMed id 16883066)^{1, 7, 9} Morand E.F....Yang Y.H. (Mediators Inflamm. 2006)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Phosphorylation of annexin I by TRPM7 channel-kinase. (PubMed id 15485879)^{1, 2} Dorovkov M.V. and Ryazanov A.G. (J. Biol. Chem. 2004)
[Absence of evidence for the association of single nucleotide polymorphisms in Annexin A1 gene with type 2 diabetes in Chinese]. (PubMed id 15476183)^{1, 4} Dong Y....Luo M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Characterization of the annexin I gene and evaluation of its role in type 2 diabetes. (PubMed id 11574426)^{1, 4} Lindgren C.M....Groop L.C. (Diabetes 2001)
NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit. (PubMed id 9915835)^{1, 2} Gao J.... Yan H. (J. Biol. Chem. 1999)
Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. (PubMed id 8425544)^{1, 2} Arcone R.... Ciliberto G. (Eur. J. Biochem. 1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 301	HGNC: 533	AceView: ANXA1	Ensembl:ENSG00000135046	euGenes: HUgn301
ECgene: ANXA1	H-InvDB: ANXA1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ANXA1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ANXA1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ANXA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ANXA1 gene:
Search GeneIP for patents involving ANXA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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