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ANXA1 Gene(Protein Coding)

Annexin A1

GCID:
GC09P073151
GIFtS:
70
Genes Participants
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Aliases for ANXA1 Gene

Aliases for ANXA1 Gene

  • Annexin A1 2 3 5
  • Phospholipase A2 Inhibitory Protein 3 4
  • Chromobindin-9 3 4
  • Calpactin II 3 4
  • Calpactin-2 3 4
  • Annexin-1 3 4
  • ANX1 3 4
  • LPC1 3 4
  • Annexin I (Lipocortin I) 3
  • Lipocortin I 4
  • Annexin I 4
  • P35 4

External Ids for ANXA1 Gene

Previous HGNC Symbols for ANXA1 Gene

  • ANX1
  • LPC1

Previous GeneCards Identifiers for ANXA1 Gene

  • GC09P066811
  • GC09P067623
  • GC09P069336
  • GC09P071223
  • GC09P072996
  • GC09P074956
  • GC09P075766
  • GC09P045589

Summaries for ANXA1 Gene

Entrez Gene Summary for ANXA1 Gene

  • This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]

GeneCards Summary for ANXA1 Gene

ANXA1 (Annexin A1) is a Protein Coding gene. Diseases associated with ANXA1 include Hairy Cell Leukemia and Brain Edema. Among its related pathways are Peptide ligand-binding receptors and RET signaling. GO annotations related to this gene include calcium ion binding and receptor binding. An important paralog of this gene is ANXA2.

UniProtKB/Swiss-Prot for ANXA1 Gene

  • Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).

Tocris Summary for ANXA1 Gene

  • Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.

Gene Wiki entry for ANXA1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA1 Gene

Genomics for ANXA1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ANXA1 Gene

Enhancers for ANXA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G073117 1.5 FANTOM5 Ensembl ENCODE dbSUPER 16.2 -33.0 -32998 2.3 TBP ESRRA NFIB JUN MAX CEBPG RFX5 FOSL1 NFE2 FOS ANXA1 ALDH1A1 GC09P073115 GC09P073141
GH09G073115 1.4 FANTOM5 Ensembl ENCODE dbSUPER 15.7 -35.5 -35489 0.9 MAFF ZNF316 JUND MAFG JUNB EMSY MAFK ANXA1 ALDH1A1 GC09P073115 GC09P073141
GH09G073147 1.6 FANTOM5 ENCODE dbSUPER 12.7 +0.7 713 9.6 PKNOX1 CREB3L1 ARNT ZFP64 SIN3A FEZF1 ZNF766 FOS JUNB REST ANXA1 GC09M073159 PIR62868
GH09G073125 0.7 ENCODE dbSUPER 19.5 -25.9 -25892 0.2 ZNF664 ATF3 ANXA1 GC09P073115 GC09P073141
GH09G073176 0.7 ENCODE 12.3 +24.9 24946 1.2 GTF2F1 MXI1 TAF1 JUN MAX SMC3 RCOR1 FOS CHD2 TCF7L2 ANXA1 ALDH1A1 GC09M073140 GC09P073193
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANXA1 on UCSC Golden Path with GeneCards custom track

Promoters for ANXA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000235987 1269 2801 HDAC1 TBP SIN3A BMI1 RFX5 TCF12 ZNF766 FOS IKZF2 NFYA

Transcription factor binding sites by QIAGEN in the ANXA1 gene promoter:

Genomic Location for ANXA1 Gene

Chromosome:
9
Start:
73,151,731 bp from pter
End:
73,170,393 bp from pter
Size:
18,663 bases
Orientation:
Plus strand

Genomic View for ANXA1 Gene

Genes around ANXA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ANXA1 Gene

Proteins for ANXA1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ANXA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04083-ANXA1_HUMAN
    Recommended name:
    Annexin A1
    Protein Accession:
    P04083

    Protein attributes for ANXA1 Gene

    Size:
    346 amino acids
    Molecular mass:
    38714 Da
    Quaternary structure:
    • Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation (PubMed:2532504). Homodimers linked by transglutamylation are observed in placenta, but not in other tissues (PubMed:2532504). Interacts with S100A11 (PubMed:8557678, PubMed:10673436). Heterotetramer, formed by two molecules each of S100A11 and ANXA1 (PubMed:10673436). Interacts with DYSF (By similarity). Interacts with EGFR (By similarity).
    Miscellaneous:
    • Was originally identified as calcium and phospholipid binding protein that displays Ca(2+)-dependent binding to phospholipid membranes and can promote membrane aggregation in vitro. Was initially identified as inhibitor of phospholipase A2 activity (in vitro) (PubMed:2936963, PubMed:8425544). Inhibition of phospholipase activity is mediated via its phospholipid binding activity that limits the access of phospholipase to its substrates.

    Three dimensional structures from OCA and Proteopedia for ANXA1 Gene

neXtProt entry for ANXA1 Gene

Protein Expression for ANXA1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ANXA1 Gene

  • Phosphorylated by protein kinase C, EGFR and TRPM7 (PubMed:2457390, PubMed:15485879). Phosphorylated in response to EGF treatment (PubMed:2532504).
  • Sumoylated.
  • Ubiquitination at Lys58, posLast=166166, and posLast=274274
  • Modification sites at PhosphoSitePlus

Other Protein References for ANXA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANXA1 (ANXA1)
  • Cloud-Clone Corp. Antibodies for ANXA1

No data available for DME Specific Peptides for ANXA1 Gene

Domains & Families for ANXA1 Gene

Gene Families for ANXA1 Gene

HGNC:

Protein Domains for ANXA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ANXA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04083

UniProtKB/Swiss-Prot:

ANXA1_HUMAN :
  • The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
  • Belongs to the annexin family.
Domain:
  • The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
  • The N-terminal 26 amino acids are sufficient for its extracellular functions in the regulation of inflammation and wound healing (PubMed:25664854). Acylated peptides that contain the first 26 amino acids of the mature protein can activate signaling via the formyl peptide receptors (PubMed:15187149, PubMed:25664854).
Family:
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA1: view

Function for ANXA1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ANXA1 Gene

GENATLAS Biochemistry:
annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of the organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid feadback action in the hypothalamo-hypophysial system
UniProtKB/Swiss-Prot Function:
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).

Gene Ontology (GO) - Molecular Function for ANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IEA --
GO:0003727 single-stranded RNA binding IEA --
GO:0004386 helicase activity IEA --
GO:0004859 phospholipase inhibitor activity IEA --
GO:0005102 receptor binding TAS 10882119
genes like me logo Genes that share ontologies with ANXA1: view
genes like me logo Genes that share phenotypes with ANXA1: view

Animal Models for ANXA1 Gene

MGI Knock Outs for ANXA1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANXA1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ANXA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANXA1 Gene

Localization for ANXA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA1 Gene

Nucleus. Cytoplasm. Cell projection, cilium. Cell membrane. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Basolateral cell membrane. Apical cell membrane. Lateral cell membrane. Secreted. Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted, exosome. Cytoplasmic vesicle, secretory vesicle lumen. Cell projection, phagocytic cup. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). {ECO:0000250 UniProtKB:P10107, ECO:0000269 PubMed:10772777, ECO:0000269 PubMed:17008549, ECO:0000269 PubMed:2532504, ECO:0000269 PubMed:25664854, ECO:0000269 PubMed:8557678}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
endosome 5
mitochondrion 3
lysosome 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IDA 10908733
GO:0001891 phagocytic cup IEA --
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA,IEA 17008549
GO:0005634 nucleus IDA 22056994
genes like me logo Genes that share ontologies with ANXA1: view

Pathways & Interactions for ANXA1 Gene

genes like me logo Genes that share pathways with ANXA1: view

SIGNOR curated interactions for ANXA1 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for ANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000733 DNA strand renaturation IEA --
GO:0001780 neutrophil homeostasis IMP 21957127
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002548 monocyte chemotaxis IDA 15187149
genes like me logo Genes that share ontologies with ANXA1: view

Drugs & Compounds for ANXA1 Gene

Products:

  1. Drug

(49) Drugs for ANXA1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist, agonist, Target 2171
Amcinonide Approved Pharma agonist, Target 0
Hydrocortisone Approved, Vet_approved Pharma Agonist, Target, agonist Adrenal glucocorticoid; immunosuppressant 667
Prednisolone Approved, Vet_approved Pharma Agonist, binder 1193
Alclometasone Approved Pharma binder 0

(32) Additional Compounds for ANXA1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ac2-26
151988-33-9
Echistatin, alpha1 isoform
154303-05-6
Heparin sodium salt
9041-08-1

(5) Tocris Compounds for ANXA1 Gene

Compound Action Cas Number
Ac2-26 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 151988-33-9
BIO 5192 Highly potent and selective inhibitor of integrin alpha4beta1 327613-57-0
Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor 154303-05-6
Heparin sodium salt Anticoagulant 9041-08-1
RGDS peptide Integrin binding sequence; inhibits integrin receptor function 91037-65-9

(1) ApexBio Compounds for ANXA1 Gene

Compound Action Cas Number
Thiolutin RNA polymerase inhibitor,antibiotic 1987-11-6
genes like me logo Genes that share compounds with ANXA1: view

Drug Products

Transcripts for ANXA1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ANXA1 Gene

(3) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(1569) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANXA1 Gene

Annexin A1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ANXA1

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - - - -
SP10: - - -
SP11:
SP12: -
SP13:

Relevant External Links for ANXA1 Gene

GeneLoc Exon Structure for
ANXA1
ECgene alternative splicing isoforms for
ANXA1

Expression for ANXA1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANXA1 Gene

mRNA expression in normal human tissues for ANXA1 Gene
mRNA expression by BioGPS for ANXA1 GenemRNA expression by GTEx for ANXA1 Gene

mRNA differential expression in normal tissues according to GTEx for ANXA1 Gene

This gene is overexpressed in Esophagus - Mucosa (x19.5) and Minor Salivary Gland (x6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANXA1 Gene



Protein tissue co-expression partners for ANXA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANXA1 Gene:

ANXA1

SOURCE GeneReport for Unigene cluster for ANXA1 Gene:

Hs.494173

mRNA Expression by UniProt/SwissProt for ANXA1 Gene:

P04083-ANXA1_HUMAN
Tissue specificity: Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.

Evidence on tissue expression from TISSUES for ANXA1 Gene

  • Liver(4.9)
  • Lung(4.9)
  • Nervous system(4.4)
  • Bone(4)
  • Skin(3.6)
  • Stomach(3.6)
  • Blood(3.4)
  • Thyroid gland(3.4)
  • Bone marrow(3.3)
  • Intestine(3.3)
  • Heart(3.2)
  • Spleen(2.8)
  • Kidney(2.6)
  • Muscle(2.5)
  • Adrenal gland(2.4)
  • Gall bladder(2.4)
  • Lymph node(2.4)
  • Pancreas(2.2)
  • Eye(2)
genes like me logo Genes that share expression patterns with ANXA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA1 Gene

Orthologs for ANXA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ANXA1 34 35
  • 99.42 (n)
dog
(Canis familiaris)
 Mammalia ANXA1 34 35
  • 89.53 (n)
cow
(Bos Taurus)
 Mammalia ANXA1 34 35
  • 88.57 (n)
mouse
(Mus musculus)
 Mammalia Anxa1 34 16 35
  • 86.61 (n)
rat
(Rattus norvegicus)
 Mammalia Anxa1 34
  • 86.13 (n)
oppossum
(Monodelphis domestica)
 Mammalia ANXA1 35
  • 86 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ANXA1 35
  • 81 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ANXA1 34 35
  • 75.07 (n)
lizard
(Anolis carolinensis)
 Reptilia ANXA1 35
  • 76 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia anxa1 34
  • 69.73 (n)
MGC76270 34
African clawed frog
(Xenopus laevis)
 Amphibia anxa1-prov 34
zebrafish
(Danio rerio)
 Actinopterygii anxa1a 34 35
  • 65.49 (n)
ANXA1 (4 of 4) 35
  • 52 (a)
 OneToMany
anxa1b 35
  • 52 (a)
 OneToMany
anxa1c 35
  • 51 (a)
 OneToMany
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8605 34
fruit fly
(Drosophila melanogaster)
 Insecta AnnIX 36
  • 45 (a)
worm
(Caenorhabditis elegans)
 Secernentea nex-2 36
  • 42 (a)
nex-1 35 36
  • 36 (a)
 ManyToMany
nex-3 36 35
  • 35 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 36 (a)
 ManyToMany
Species where no ortholog for ANXA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA1 Gene

ENSEMBL:
Gene Tree for ANXA1 (if available)
TreeFam:
Gene Tree for ANXA1 (if available)

Paralogs for ANXA1 Gene

Paralogs for ANXA1 Gene

(15) SIMAP similar genes for ANXA1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ANXA1: view

Variants for ANXA1 Gene

Sequence variations from dbSNP and Humsavar for ANXA1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000241754 -- 73,170,167(+) ATCCT(A/G)TAAGC utr-variant-3-prime
rs1000266047 -- 73,154,568(+) TGAGT(A/G)GATGG intron-variant, utr-variant-5-prime
rs1000373649 -- 73,153,274(+) ATATG(A/T)CGTTA intron-variant, upstream-variant-2KB
rs1000594415 -- 73,153,045(+) TGCAA(A/T)TGACT intron-variant, upstream-variant-2KB
rs1000754947 -- 73,166,252(+) CTATC(C/T)TATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA1 Gene

Variant ID Type Subtype PubMed ID
esv3620660 CNV loss 21293372
esv3620661 CNV gain 21293372
esv3620662 CNV gain 21293372
nsv526225 CNV gain 19592680
nsv614612 CNV gain 21841781
nsv6561 CNV insertion 18451855
nsv951528 CNV duplication 24416366

Variation tolerance for ANXA1 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANXA1 Gene

Human Gene Mutation Database (HGMD)
ANXA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANXA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA1 Gene

Disorders for ANXA1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ANXA1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hairy cell leukemia
  • hcl-v
brain edema
  • intracranial swelling
rheumatoid arthritis
  • rheumatoid arthritis, progression of
lung cancer susceptibility 3
  • lung adenocarcinoma
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards
Search ANXA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ANXA1

Genetic Association Database (GAD)
ANXA1
Human Genome Epidemiology (HuGE) Navigator
ANXA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANXA1
genes like me logo Genes that share disorders with ANXA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA1 Gene

Publications for ANXA1 Gene

  1. Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PMID: 16883066) Morand E.F. … Yang Y.H. (Mediators Inflamm. 2006) 3 22 25 64
  2. Calcium-dependent binding of S100C to the N-terminal domain of annexin I. (PMID: 8557678) Mailliard W.S. … Schlaepfer D.D. (J. Biol. Chem. 1996) 3 4 22 64
  3. Crystal structure of human annexin I at 2.5-A resolution. (PMID: 8453382) Weng X. … Huber R. (Protein Sci. 1993) 3 4 22 64
  4. Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PMID: 2936963) Wallner B.P. … Pepinsky R.B. (Nature 1986) 2 3 4 64
  5. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. (PMID: 25664854) Leoni G. … Nusrat A. (J. Clin. Invest. 2015) 3 4 64

Products for ANXA1 Gene

  • Addgene plasmids for ANXA1

Sources for ANXA1 Gene

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