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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANXA1 Gene

protein-coding   GIFtS: 71
GCID: GC09P075766

Annexin A1


(Previous symbols: ANX1, LPC1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Annexin A11 2     annexin-12
LPC11 2 3 5     calpactin-22
ANX11 2 3     chromobindin-92
Calpactin II2 3     Annexin-13
Lipocortin I2 3     Calpactin-23
Phospholipase A2 Inhibitory Protein2 3     Chromobindin-93
p352 3     Annexin I3
Annexin I (Lipocortin I)2     

External Ids:    HGNC: 5331   Entrez Gene: 3012   Ensembl: ENSG000001350467   OMIM: 1516905   UniProtKB: P040833   

Export aliases for ANXA1 gene to outside databases

Previous GC identifers: GC09P066811 GC09P067623 GC09P069336 GC09P071223 GC09P072996 GC09P074956 GC09P045589


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANXA1 Gene:
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of
approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane.
Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity.
Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins
and leukotrienes, annexin I may have potential anti-inflammatory activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for ANXA1 Gene: 
ANXA1 (annexin A1) is a protein-coding gene. Diseases associated with ANXA1 include brain edema, and colon adenocarcinoma, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include phospholipid binding and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Gene Wiki entry for ANXA1 (Annexin A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANXA1 gene promoter:
         C/EBPbeta   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   AREB6   POU2F1   POU2F1a   STAT3   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ANXA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANXA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q21.13

ANXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P075766:  view genomic region     (about GC identifiers)

Start:
75,766,673 bp from pter      End:
75,785,309 bp from pter
Size:
18,637 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083 (See protein sequence)
Recommended Name: Annexin A1  
Size: 346 amino acids; 38714 Da
Subunit: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity).
Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of
ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and
alveolar macrophages (By similarity)
3 PDB 3D structures from and Proteopedia for ANXA1:
1AIN (3D)        1BO9 (3D)        1QLS (3D)    

Explore the universe of human proteins at neXtProt for ANXA1: NX_P04083

Explore proteomics data for ANXA1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in
    loss of the inhibitory activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04083

  • ANXA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANXA1 Protein Expression
    REFSEQ proteins: NP_000691.1  
    ENSEMBL proteins: 
     ENSP00000257497   ENSP00000412489   ENSP00000414013   ENSP00000366109  
    Reactome Protein details: P04083
    Human Recombinant Protein Products for ANXA1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ANXA1 (Annexin A1)
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    OriGene Purified Protein for ANXA1
    OriGene Protein Over-expression Lysate for ANXA1
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    Novus Biologicals ANXA1 Proteins
    Novus Biologicals ANXA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ANXA1
    Cloud-Clone Corp. Proteins for ANXA1 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001533cornified envelope IDA10908733
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS16130169

    ANXA1 for ontologies           About GeneDecksing



    ANXA1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANXA1
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    Assay Products for ANXA1: 
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    Cloud-Clone Corp. ELISAs for ANXA1 
    Cloud-Clone Corp. CLIAs for ANXA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    ANXA: Annexins

    4 InterPro protein domains:
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR002388 AnnexinI
     IPR018502 Annexin_repeat

    Graphical View of Domain Structure for InterPro Entry P04083

    ProtoNet protein and cluster: P04083

    2 Blocks protein domains:
    IPB001464 Annexin
    IPB002388 Annexin type I signature


    UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    ANXA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANXA1_HUMAN, P04083
    Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
    protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

         Genatlas biochemistry entry for ANXA1:
    annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of
    the organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid
    feadback action in the hypothalamo-hypophysial system

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity ----
    GO:0005102receptor binding TAS10882119
    GO:0005198structural molecule activity IDA10908733
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
         
    ANXA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ANXA1:
     Decreased viability 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Anxa1):
     adipose tissue  cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     skeleton  tumorigenesis 

    ANXA1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ANXA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ANXA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANXA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANXA1 

    miRNA
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    miRTarBase miRNAs that target ANXA1:
    hsa-mir-196a (MIRT000709)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANXA1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ANXA1
    SwitchGear 3'UTR luciferase reporter plasmidANXA1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ANXA1 (NM_000700)
    Sino Biological Human cDNA Clone for ANXA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA1
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                         Customized lentivirus expression plasmids for stable overexpression of ANXA1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ANXA1 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Spinal Cord Injury
    Spinal Cord Injury
    5Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ANXA1
        Selected targets of CREB1
    Selected targets of C/EBPalpha


    1 Cell Signaling Technology (CST) Pathway for ANXA1
        Ca, cAMP and Lipid Signaling

    4 BioSystems Pathways for ANXA1
        Integrated Breast Cancer Pathway
    Spinal Cord Injury
    Prostaglandin Synthesis and Regulation
    Integrated Pancreatic Cancer Pathway


    5/10        Reactome Pathways for ANXA1 (see all 10)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    ANXA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANXA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/309 Interacting proteins for ANXA1 (P040831, 2, 3 ENSP000002574974) via UniProtKB, MINT, STRING, and/or I2D (see all 309)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBB1O002132, 3, ENSP000002994024MINT-8247707 I2D: score=2 STRING: ENSP00000299402
    C14orf1Q9UKR52, 3MINT-8247720 I2D: score=2 
    CCT7Q998322, 3MINT-8247753 I2D: score=2 
    COPS6Q7L5N12, 3MINT-8247764 I2D: score=2 
    CSADQ9Y6002, 3MINT-8247775 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001780neutrophil homeostasis IMP--
    GO:0002674negative regulation of acute inflammatory response IEA--
    GO:0006928cellular component movement TAS10882119
    GO:0006954inflammatory response TAS10882119
    GO:0007049cell cycle IEA--

    ANXA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANXA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ANXA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ThiolutinBacterial RNA polymerase inhibitor[87-11-6]
    Heparin sodium saltAnticoagulant[9041-08-1]
    Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor[154303-05-6]
    RGDS peptideIntegrin binding sequence; inhibits integrin receptor function[91037-65-9]
    Ac2-26Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation[151988-33-9]

    1 HMDB Compound for ANXA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for ANXA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Hydrocortisone11beta-Hydroxycortisone (see all 16)50-23-7targetagonist1712816 17139284 11142771 17016423 8060156
    DexamethasoneDesametasone (see all 9)50-02-2targetagonist17644190 17076770 17158208 16883066
    Amcinonide-- 51022-69-6targetagonist17139284 17016423 7981624

    10/56 Novoseek inferred chemical compound relationships for ANXA1 gene (see all 56)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hdmnkvldl 84.9 2 8818992 (1), 1793057 (1)
    phosphatidylserine 62.1 29 8179621 (3), 7627125 (1), 12744815 (1), 15381697 (1) (see all 16)
    phospholipid 59.7 33 8379935 (7), 2138536 (1), 1310621 (1), 8485141 (1) (see all 20)
    calcium 55 126 11142771 (6), 9299392 (5), 18283055 (4), 1469069 (3) (see all 58)
    arachidonic acid 49.2 16 2064175 (2), 8260938 (2), 2137129 (2), 12845669 (1) (see all 10)
    dexamethasone 45.3 54 8256657 (6), 12236584 (5), 17644190 (4), 14668092 (3) (see all 17)
    glyceraldehyde 3-phosphate 44.7 7 16220529 (1), 17268060 (1), 15274135 (1), 19899082 (1) (see all 7)
    geneticin 32.2 1 7764687 (1)
    phosphatidylcholine 30.4 17 16307464 (2), 12845669 (1), 7654693 (1), 1387325 (1) (see all 5)
    p-opc 30 7 16307464 (3), 18237543 (2)

    Search CenterWatch for drugs/clinical trials and news about ANXA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANXA1 gene: 
    NM_000700.1  

    Unigene Cluster for ANXA1:

    Annexin A1
    Hs.494173  [show with all ESTs]
    Unigene Representative Sequence: AK074480
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257497(uc004ajf.1) ENST00000468639 ENST00000456643 ENST00000415424
    ENST00000376911(uc004ajg.1) ENST00000495713 ENST00000489109 ENST00000491192


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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANXA1

    Additional mRNA sequence: 

    AB451274.1 AB451401.1 AK023330.1 AK074480.1 AK296808.1 AK311684.1 BC001275.1 BC018683.1 
    BC034157.1 BC035993.1 BT019896.1 BT019916.1 BT019917.1 CR407684.1 X05908.1 

    24/49 DOTS entries (see all 49):

    DT.95080391  DT.100890399  DT.95202652  DT.100765659  DT.100890413  DT.100890422  DT.100890394  DT.100890395 
    DT.121161786  DT.100890415  DT.95340497  DT.95223581  DT.92045136  DT.92466092  DT.100040129  DT.100890410 
    DT.100890409  DT.91793108  DT.91703452  DT.91949347  DT.121161854  DT.100890404  DT.92466082  DT.92466099 

    1569 AceView cDNA sequences (see top 24):

    CA415613 CB134453 CB116281 BU676623 BC001275 CB136196 BM987115 CB125606 
    BG680014 CB149662 CB120109 AA348570 AI923018 CB110454 CB132713 BF981334 
    CB113203 BM550642 CB110876 BF218920 CA447223 CA445329 BU506807 AK023330 
    CB159741 CR607819 CA421424 BM786699 BG748968 BI492456 CB113708 BM712226 
    CB138353 BU683687 BQ774780 BM845550 BQ182544 AI087195 BM788150 CB131848 
    AI631302 BM555842 CB127802 BG573931 CB217021 CB131932 AW117810 BM850080 
    CB138167 BG118456 AU133942 BM990412 BM996954 CB135558 BM842714 BM842361 
    CB112977 AA159054 CB124501 BU857810 CB135546 CR618229 CB043933 BP336523 
    CN484542 CB136301 CB160508 AA131951 CB409715 AU135571 BU956940 BM762676 
    CB128492 BQ434324 BM849838 CB147648 AU139656 CA446942 BX417009 CB134140 
    CB147894 BU627114 AI678828 CB134143 AW238543 CA429282 AA039810 CB132841 
    CB151251 BE885940 BM760779 BQ776006 BU187916 BM842678 CB112370 BI052409 
    BM994528 BM461778 CB135009 BQ775843 CR600988 CB139184 CB135025 AI057004 
    CB132658 CA444151 CA310269 AU077077 NM_000700 AW439690 CR602892 BC035993 
    BE889674 CF127699 BM995358 BQ775374 BQ424962 AW169048 AU138607 AW514084 
    BG573326 CB159233 AI022506 BQ222672 BM749560 CB136295 CF131650 W25534 
    CA437362 CR407684 CD679498 BQ776341 AI147775 CB135057 AL553114 CB141096 
    CB112993 CF130760 BE890043 CD709026 CB134806 CB112891 CB134840 BM995441 
    CA441813 BM556687 CA414702 BG679690 BM458053 BE746626 BQ021512 CB113217 
    AL712296 CR599722 BP379651 CB127277 BQ776306 AA010674 BQ946134 CB134127 
    CA405627 BM972091 CB147624 CA419750 CB113246 BI868606 CB125959 BQ776326 
    BM740875 CA418062 AI150668 CB134533 BM760791 CB136463 BM842373 AU135762 
    BE880201 BQ962615 AL541874 BU633206 CR626421 CA418210 BQ435367 CB134457 
    CB135270 BQ775102 BM476344 BQ435432 CB134078 BM830896 BM986777 CA434798 
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    CB155823 AI962890 BQ434247 AA715167 BQ775882 CB131626 CB132717 BQ776007 
    AU137801 BU521640 CA449230 CA418081 BE885625 CB161300 AU138129 CB147928 
    AI358733 R31786 CB108952 AL702872 BG760604 BG010285 BU615234 BQ774960 
    CD103569 BG623793 CB124638 AW057775 W42912 BM754763 CB998740 BG571202 
    AL553164 CB120815 BM463582 BE886383 BG571765 BF686527 BM842271 CB132830 
    BE886256 BQ020469 AL079950 CA419718 BU928345 BM842987 BM460109 W76438 
    AI349473 CB986517 BM803761 CB111404 BF245840 AA101915 BG573677 BU615206 
    BG620590 BG678513 BQ228162 AU138502 BQ776203 AA948331 H29760 BG435105 
    BQ929510 BE886273 BM836033 CA422051 BP366479 CD103647 BM788544 CD242178 
    BM747337 BG779520 BG571479 CD705361 AL575425 BQ439412 BG434528 BP382355 
    BG621477 BQ719960 BG619919 BQ225644 CB124594 BQ775650 BU597585 CB124350 
    BG435471 BU838395 BM851619 BG571454 BF095450 CA442302 AI719290 BG943816 
    CD688191 BG622424 BG250298 BM838687 BM837257 BG778566 BM789282 CD357777 
    BG620352 BE884472 BM756474 BQ938524 CB956847 CB114390 CB118454 AU117349 
    BG623682 CB145999 BE789424 BU521785 BG527308 BU929725 CD104334 BM760977 
    BG571367 BM847961 BG776752 BG434802 BE889391 BM968595 BM751542 BU929078 
    BE163637 BU940658 BM756535 BQ183243 CA445151 BG749612 CB111629 BM555529 
    N51341 BE889657 BE786030 CD103625 CB321626 BG252580 BQ774936 BU596129 
    BM843422 CB116745 AW129915 BU684047 CB151143 CA414442 BG436236 BU928885 
    BU928693 BG750453 BM846445 AI682729 BG681568 CB127414 R79111 BM745645 
    BX344057 D20825 BG622925 BU630502 AI818697 BM851617 BM851366 AA129310 
    CB119610 BF218446 BQ940619 AU135381 BQ774630 BU597064 CB136396 BP352802 
    BU933687 BV204059 CB125445 AW850843 AI192129 BG111978 AW513527 AL570428 
    BU684376 W42857 BE890074 BG572153 BM758432 BG622789 CB150687 BU630013 
    BM847906 H63077 CB132696 BG436155 AI299600 BU688335 AW339658 AW999255 
    AI986240 CD103971 BG573610 CA441709 CF994973 BG572467 BQ182979 CA419989 
    BG572031 BM744204 CB143442 CB962764 BG687581 BP375459 BM843952 CB126294 
    BX474299 AA554877 BM739221 CD639416 CB138653 CD721824 N59590 CB136976 
    AU139496 BM756443 BM739445 BQ937881 CB131923 BQ721913 CB108524 BU164446 
    AA962646 BG621352 BE882050 BG620205 BG036592 BX348416 CB136143 CB137469 
    BG571121 CB125577 AI984755 BM510891 BG620532 BM757785 BU958850 CB131899 
    BM846695 CB044522 BU679283 CB044951 CB994837 BM764292 AA099365 BF340792 
    AI749676 H39785 BG677869 AL574991 BM752353 BQ962667 CF595860 BM748929 
    BU180800 BU683999 CD107895 CB114461 AL576603 CA419301 BE888717 BG622681 
    BM740289 BG623470 BE160277 BG679758 BM846751 CA419446 CD684885 CA414418 
    BE613536 BU686652 CB112529 CB137328 AI499359 BM819669 BF672909 BG573351 
    CB135418 BM739365 AI306452 BM760197 CB147954 AI539640 BG337791 BU945187 
    AI031690 CB115909 BG619250 BG434661 CA419688 BX507122 BM760219 BM982862 
    AI932795 BM739866 BG620959 BM740883 CA423056 BG336968 BM738660 CB131859 
    BM807190 CD512646 BQ775193 BE784318 BE620413 AA046396 CB132820 BF149206 
    CA417844 BG620214 CA449271 BE393571 CD110331 BM845449 BE787422 BM920224 
    CB122017 BM468858 BE888097 BU752453 BM739388 BM758397 BG527055 CD000479 
    BQ776243 BU198784 BG777275 CB135677 BF972534 CB118653 BU674442 CB111030 
    AL540651 BG621285 BE883571 CA420770 BG434770 AW664152 CD109767 CB215652 
    BM847083 AI561140 BG496240 AI573175 AI037945 AL576340 BU600229 BG624029 
    AW467650 W07418 BM740086 BE885684 BF672419 BG620225 CB963360 BG620876 
    BF445884 BG679589 BF037244 CD638542 AL570884 AW118316 BE160359 BG545788 
    CF596030 AU135525 BM462354 BG572320 AW192618 AI085396 BM888427 AI828147 
    BG435187 N33815 BG624090 CK823785 CA415933 CB108957 AU137370 CB113086 
    BM788031 BU629961 CB122051 BG167328 BU178154 AI538710 BG619843 BG573340 
    BG571562 BM754322 BU508007 CB853761 BU928685 AI963054 BU508760 N69948 
    BC018683 BG623205 BG434991 BM754761 CB132652 CD103473 BU929502 BM839488 
    CD558409 BF980563 BG573502 AI886488 CB151936 BG570715 W81113 BM740228 
    BG435433 BG702992 BG623139 BF979239 AL576223 BG687189 BU930491 BM745701 
    BU928601 BU502272 BE889354 AA363572 BQ221472 BM843593 BI256470 BU929743 
    BM842421 AL553679 BE890010 BQ723044 W84575 BQ574852 BG621339 BG116608 
    BG572901 BF149207 BG572458 BU627440 BM846290 AI280717 CD109243 W80525 
    BQ718082 BG534763 CB267064 BU957173 CB135074 BM743950 AA581405 AV714294 
    BM995280 BF980977 AI066807 AA011261 BC034157 AI955777 BG571090 BG573501 
    BM747889 BG434942 BM843042 BG620898 BM762707 AW029347 AA327460 CB962367 
    BU789080 CF147180 AU137127 CB120356 BG571516 BE613538 CB111615 BQ775247 
    CA417944 AW021498 BF683998 CB135462 BU173056 BG570750 BG681724 CB129393 
    BU521988 BM740144 BG534436 CF528314 CB127544 AI147859 BE614257 CD639441 
    BE869220 BG623808 BE889096 BQ224201 BG435452 BM747375 BU751757 BG164494 
    BM048854 CD000474 BQ422205 BF973004 AU135221 CB111024 BV204060 BM747733 
    BG681137 BI752394 BG623830 CB112716 CB126252 BG528322 AL541443 BM771850 
    AL691612 AV757833 BU681987 AI979080 CB043934 BM744729 CB137972 CB134621 
    CB125827 BG339459 AU136700 BG562579 BQ016213 AI094311 BU521798 AI818672 
    BM887966 BE019690 CD684477 BG121427 BM844210 BG571271 AW473645 BP370919 
    CB955986 CD687517 CA440642 BG620758 AL551427 BQ962035 AI670795 BU858319 
    AU122831 CA420206 BM477702 CB956944 AL551980 BG547240 CF146870 BU928797 
    BE883722 AW239219 AV734845 BU928528 BE613877 CB962188 BM752075 AI338272 
    BM983867 BM473319 BP374665 BP342993 CA442311 BM750832 BM454970 AI086736 
    N78655 BU929436 BG434791 BM744229 CD250663 BM740085 AI367059 CB121925 
    BF685893 T64980 BG250705 W15144 BX501336 BM762941 BG573210 CB111034 
    BM746343 BM462335 AL544231 BG119474 CB122107 BM759959 CB125306 BG534570 
    BM760875 AL553129 BM748919 BM743253 CA449033 BE890028 BG117049 AV756113 
    BI868345 AU138813 AV717869 BG573430 BM856193 CD000909 BM760191 CF127674 
    BQ775387 CB135055 AI680227 AA046308 BU674368 CD691486 BQ775183 BU929760 
    BM845532 CB115529 CB267332 CB963002 AI039844 BM746981 BM794647 CD677426 
    BU173401 BM851325 CB956365 AW468040 BM845717 BG779213 AI022270 BQ954100 
    BM759170 AW262781 BE889618 AU136839 AU139272 CB111403 BF980639 CD102824 
    BP381696 BU902298 AW079763 CF454990 BM847088 BM993633 W80526 AA039737 
    AI270599 BG573253 CB127311 BU679642 BG620689 BM746402 BM758543 BM842508 
    AL542692 BG547036 AW275945 W48727 CB113742 AI540773 BE858148 AA040524 
    BF696507 W37911 BG435508 BG899315 BG398702 BE163643 AI279070 BF219314 
    BF673438 AA346298 BG287303 N67836 AI687462 BM828795 CB119021 BG539465 
    BF038449 BU628720 AI826887 AI624277 BU570993 BQ775612 BG622060 AL709482 
    AL603330 N62387 BG290890 BF696793 BU508540 CB136115 BG620595 BM739854 
    BG624009 AV733665 CB126846 BM759488 BG435268 AW366472 BM739318 BF088984 
    H63161 BG435073 BU506634 CB270261 BE738188 CD299790 AU156892 CD687235 
    BI085829 AV756671 CF146869 BM750521 CD695323 CB998055 AW238266 C18232 
    AW366462 BP383615 BE720764 BU940400 AL541873 AA129354 AL601158 CB106901 
    BU789342 CB997886 BF671133 BP351463 BE738025 CB958575 BP382579 BG255938 
    BE315143 H98885 CD514880 BX365112 CD703594 CB124198 BF107418 BG619381 
    CA418335 BP352484 BM843659 BM739930 BE720604 AV761675 CD702358 CB961976 
    CD638732 CD706274 AA319694 BG253756 CB136074 AA903464 BF971769 BQ019474 
    AI266490 BG766411 BF243458 BM740013 W19292 AW804129 BM511137 BE933725 
    BG619561 BP335322 BF029110 AW337908 CB957903 BF107233 BF244163 BM842587 
    AU157482 BM844197 BF107108 CA419564 BM822987 BU632561 AW022429 BG776062 
    CB987639 CD357534 AW265418 H98992 BM844811 N81077 BE883891 BM754252 
    AI337825 BM748957 BG538873 BG572361 BG619228 AA975685 AI338043 AA040523 
    AA885878 AI764962 CF541379 BF215528 AA159055 BF790680 BE789848 BE777467 
    BF245291 BM747414 BU752523 BM739198 BU509156 CB045799 AI682611 BM838991 
    AA932100 BM845285 CD695322 BG899264 BG540978 BG687509 BG340446 CB854645 
    BQ694023 BE139643 AI811218 AA166969 CD697017 AI023174 BF672562 D58885 
    N24938 BF246106 BF700315 CD686637 AW862567 BE161231 BG924221 CA407565 
    AU158118 CB159497 H67182 BG620117 BE439455 AL569557 BE874337 BE885645 
    R70897 CB136066 BQ278422 CD686458 BX480257 BG538819 BM751595 CD697943 
    BF698764 BE004257 AW366471 CD703906 BE185259 BE176399 BF107498 CB121918 
    CD690810 CD700391 BG494471 BU752360 AL568911 BM739299 AA583722 BF685662 
    BE160371 BG573239 N47897 AV748590 AW591195 BG435737 CD000719 CD687060 
    CD689301 CB409714 N47174 CD694381 BG434635 CD103285 AU122830 CD690837 
    CD703196 BF242795 CD702693 BF217410 CB116217 CD688703 AL553095 R70896 
    BF031223 BU680229 BE567857 BG900706 BQ774022 CD692581 BG928764 CD693933 
    AV716730 BF573009 BE147909 BQ336043 AV747314 CD707727 BF130804 CD689254 
    CD706936 BU929127 BG896171 BX397194 W84645 W01767 N98329 CD109274 
    AU155902 CD698703 CB151366 BU688602 BE925543 BE711116 AV757230 BG623705 
    AW361177 CD686862 AU156107 BM844678 AI129114 CD684470 BU752675 CD691742 
    AI721155 BE160289 BM888285 BE785202 CD700733 BG007942 N51352 CD699329 
    AW950757 AI865855 AV763314 AA852087 BF088979 BE925544 BM846654 CD699670 
    CD690005 CD702736 BI012577 BE712360 AU156143 CD250376 AI540583 CD699759 
    BF905554 BQ335285 BE620646 CB117763 AA449864 AI570887 AI361977 CD688118 
    AA026981 BM848473 CD684049 BE865476 BU945485 BE566362 AU144202 BE884608 
    N94343 AV714843 BQ427863 BM845557 CD103464 BI052224 BE932977 BI085188 
    BF242088 BE546162 CD299514 AW366525 AW800507 R68218 AW496835 AW366467 
    AL703125 BM850367 AI073585 CD704955 BE565189 CD706490 AI446311 AI682127 
    BF905537 CD356781 R31078 BG541130 BE383656 BF904444 BG184369 BF214785 
    BF921635 BF750549 BF665298 BG993544 BM171959 BG623652 BU509361 AW960307 
    BF989835 BF154724 BM740242 BG537207 BU198917 BF243102 BG529687 BE720571 
    R95461 BF735916 BM751077 BG008406 BF735988 BF904437 CD692816 AU100582 
    AA846272 CD685271 BG436005 BE172402 CD707908 BE784321 BE567062 W03440 
    BF326986 AW368553 AA344036 BM855347 H26949 BF218154 CD357335 W48630 
    N79355 R79110 BF369720 BM146900 AI949487 BQ331329 BG927740 AU157321 
    BE719992 W72791 AV756589 BE567581 AI282740 BG999470 CB125460 H75713 
    AI582574 BF089413 N53997 BE171873 BG545900 CB993260 BE932321 R74083 
    CD242053 BF475353 BF245980 AU155094 BF107150 AA095650 AA357057 CD102626 
    BE932349 AI758653 AA737109 AW262752 AL573446 R74084 AW606762 H01087 
    BQ366085 BF692781 AI302921 CD522452 BQ027046 AI567775 BM955812 AA031662 
    BG250812 AV716650 BF736086 BM462609 BF245428 CD298759 AV713049 H67860 
    AI708665 BE886263 BE163913 AI023056 AV757969 AW366477 H95014 BF243032 
    CF126160 AI818691 T50599 CB986145 AA095823 CB999774 BG573821 AA927497 
    CD356648 BE172555 BF986460 CD110544 R76864 BE547632 AV756534 AI587504 
    BG572789 BE169685 BG118490 BG007934 AW379821 AV755997 BG571093 AW273023 
    BF245668 BG030819 BF089377 BQ379073 BE172191 T50464 BF985295 AI269234 
    BF028253 BE169826 AW379698 BF369722 BU506953 BF351532 BE708485 BF832806 
    BE711979 BF154713 W80546 AW842233 AW960301 R75849 BF241022 BF985267 
    N63017 BF217501 BM453043 BM802205 R68513 BU162389 BM809820 BF747975 
    AA186409 BF369745 BE171982 BQ329288 BG165824 R25615 BG570818 BF900810 
    CD702271 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:              -     -     -     -     -                 -           -                 -                             -                 -                     
    SP2:                                                        -           -                 -                             -                 -                     
    SP3:              -           -     -     -                 -           -                 -                             -                                       
    SP4:                                                                                      -                             -                                       
    SP5:                    -     -     -     -                 -           -                 -                                                                     


    ECgene alternative splicing isoforms for ANXA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANXA1 expression in normal human tissues (normalized intensities)      ANXA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAAGATGT
    ANXA1 Expression
    About this image


    ANXA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Lung (Respiratory System)    fully expand to see all 6 entries
             Trachea
             lung ; pneumocytes   
             visceral organ/lung/right lung   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Cerebral Cortex
             Ciliary Ganglion   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See ANXA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANXA1

    SOURCE GeneReport for Unigene cluster: Hs.494173
        SABiosciences Expression via Pathway-Focused PCR Array including ANXA1: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ANXA1
    OriGene qSTAR qPCR primer pairs in human, mouse for ANXA1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ANXA1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anxa11 , 5 annexin A11, 5 86.61(n)1
    87.57(a)1
      19 (13.83 cM)5
    169521  NM_010730.21  NP_034860.21 
     203734285 
    chicken
    (Gallus gallus)
    Aves ANXA11 annexin A1 75.07(n)
    78.59(a)
      404271  NM_206906.1  NP_996789.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA16
    Annexin
    76(a)
    1 ↔ 1
    2(47804835-47822960)
    African clawed frog
    (Xenopus laevis)
    Amphibia anxa1-prov2 annexin A1 77.96(n)    BC053786.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anxa1a2 annexin A1a 73.36(n)   334724  AY178793.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nex-23 Annexin 42(a)
    (best of 3)
      III(10397630-10399688)   --


    ENSEMBL Gene Tree for ANXA1 (if available)
    TreeFam Gene Tree for ANXA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANXA1 gene
    ANXA32  ANXA62  ANXA52  ANXA92  ANXA22  ANXA72  ANXA82  ANXA112  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA1 using alignment to 6 protein entries:     ANXA1_HUMAN (see all proteins):
    ANXA2    ANXA2P2    DKFZp686H02120    ANXA13    ANXA7    ANXA11
    ANXA3    ANXA8L1    ANXA4    ANXA5    ANXA8L2    ANXA8
    ANXA6    ANXA9    ANXA10

    ANXA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/449 SNPs in ANXA1 are shown (see all 449)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127652951,2
    C,F--75764783(+) TAGTGG/ACTTTC 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs23103121,2
    C,F,O,A,H--75764998(+) CAAAGC/AAAAAT 1 -- us2k124Minor allele frequency- A:0.19NA NS EA WA 2694
    rs1390908591,2
    --75765039(+) TTTTAC/TAAAAA 1 -- us2k10--------
    rs1423959281,2
    --75765093(+) AGGAAA/TGTTCC 1 -- us2k10--------
    rs37583551,2
    C,F,H--75765100(+) TTCCAA/GTAGTT 1 -- us2k15Minor allele frequency- G:0.02EA NS 1898
    rs1929154221,2
    --75765212(+) TATTAA/GAAAGT 1 -- us2k10--------
    rs785905931,2
    C--75765229(+) ACATCT/CGTCAA 1 -- us2k13Minor allele frequency- C:0.08CSA WA 121
    rs1851810361,2
    --75765234(+) TGTCAA/GGATCA 1 -- us2k10--------
    rs339429881,2
    C--75765264(+) ACTTA-/ACTTGT 1 -- us2k10--------
    rs1170381621,2
    F--75765351(+) GATTAG/CATGAT 1 -- us2k11Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for ANXA1 (75766673 - 75785309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ANXA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6561CNV Insertion18451855
    nsv526225CNV Gain19592680
    nsv519796CNV Gain19592680
    nsv893452CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 151690    OMIM disorders: --

    20/69 diseases for ANXA1 (see all 69):    About MalaCards
    brain edema    colon adenocarcinoma    uterine fibroid    oral cancer
    prostate adenocarcinoma    hairy cell leukemia    sarcoidosis    pulmonary sarcoidosis
    non-hodgkin lymphoma    hodgkin's lymphoma    lung adenocarcinoma    psoriatic arthritis
    idiopathic pulmonary fibrosis    stomach cancer    oral squamous cell carcinoma    adenocarcinoma
    endocarditis    laryngeal squamous cell carcinoma    esophageal squamous cell carcinoma    pulmonary fibrosis

    1 disease from the University of Copenhagen DISEASES database for ANXA1:
    Carcinoma

    ANXA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/52 Novoseek inferred disease relationships for ANXA1 gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 41.2 25 15447985 (3), 12242662 (2), 18297688 (2), 12679902 (2) (see all 17)
    adenocarcinoma lung 38.7 5 17351649 (2), 17974280 (1)
    inflammation 32.3 33 9796991 (3), 15962097 (3), 19104500 (2), 9831319 (1) (see all 21)
    premalignant 27 6 10448305 (1), 19351789 (1), 19101730 (1), 14695321 (1)
    tumors 24.8 58 16270603 (4), 19173988 (3), 17340616 (3), 18652761 (3) (see all 29)
    prostatic intraepithelial neoplasia 23.9 4 16324197 (2), 11801547 (1)
    colon adenocarcinoma 23.9 6 15526283 (3), 18541673 (2)
    oral cancer 21.1 6 18297688 (2), 20371204 (1), 12870656 (1)
    cancer 16.7 34 18663355 (4), 20215502 (2), 16324197 (2), 20371204 (1) (see all 15)
    metastasis 16.6 22 18535914 (3), 20353277 (3), 18776816 (3), 18223218 (2) (see all 11)

    Genetic Association Database (GAD): ANXA1
    Human Genome Epidemiology (HuGE) Navigator: ANXA1 (6 documents)

    Export disorders for ANXA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANXA1 gene, integrated from 9 sources (see all 541):
    (articles sorted by number of sources associating them with ANXA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PubMed id 2936963)1, 2, 3 Wallner B.P.... Pepinsky R.B. (1986)
    2. Crystal structure of human annexin I at 2.5-A resolution. (PubMed id 8453382)1, 2, 9 Weng X.... Huber R. (1993)
    3. Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PubMed id 16883066)1, 7, 9 Morand E.F....Yang Y.H. (2006)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Phosphorylation of annexin I by TRPM7 channel-kinase. (PubMed id 15485879)1, 2 Dorovkov M.V. and Ryazanov A.G. (2004)
    6. [Absence of evidence for the association of single nucleotide polymorphisms in Annexin A1 gene with type 2 diabetes in Chinese] (PubMed id 15476183)1, 4 Dong Y....Luo M. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Characterization of the annexin I gene and evaluation of its role in type 2 diabetes. (PubMed id 11574426)1, 4 Lindgren C.M....Groop L.C. (2001)
    9. NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit. (PubMed id 9915835)1, 2 Gao J.... Yan H. (1999)
    10. Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. (PubMed id 8425544)1, 2 Arcone R.... Ciliberto G. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 301 HGNC: 533 AceView: ANXA1 Ensembl:ENSG00000135046 euGenes: HUgn301
    ECgene: ANXA1 H-InvDB: ANXA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANXA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANXA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANXA1 gene:
    Search GeneIP for patents involving ANXA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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