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ANXA1 Gene

protein-coding   GIFtS: 71
GCID: GC09P075766

Annexin A1


(Previous symbols: ANX1, LPC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Annexin A11 2     annexin-12
LPC11 2 3 5     calpactin-22
ANX11 2 3     chromobindin-92
Calpactin II2 3     Annexin-13
Lipocortin I2 3     Calpactin-23
Phospholipase A2 Inhibitory Protein2 3     Chromobindin-93
p352 3     Annexin I3
Annexin I (Lipocortin I)2     

External Ids:    HGNC: 5331   Entrez Gene: 3012   Ensembl: ENSG000001350467   OMIM: 1516905   UniProtKB: P040833   

Export aliases for ANXA1 gene to outside databases

Previous GC identifers: GC09P066811 GC09P067623 GC09P069336 GC09P071223 GC09P072996 GC09P074956 GC09P045589


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANXA1 Gene:
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of
approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane.
Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity.
Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins
and leukotrienes, annexin I may have potential anti-inflammatory activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for ANXA1 Gene:
ANXA1 (annexin A1) is a protein-coding gene. Diseases associated with ANXA1 include brain edema, and colon adenocarcinoma. GO annotations related to this gene include phospholipid binding and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Gene Wiki entry for ANXA1 (Annexin A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANXA1 gene promoter:
         C/EBPbeta   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   AREB6   POU2F1   POU2F1a   STAT3   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ANXA1 promoter sequence
   Search Chromatin IP Primers for ANXA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANXA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q21.13

ANXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P075766:  view genomic region     (about GC identifiers)

Start:
75,766,673 bp from pter      End:
75,785,309 bp from pter
Size:
18,637 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083 (See protein sequence)
Recommended Name: Annexin A1  
Size: 346 amino acids; 38714 Da
Subunit: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity)
3 PDB 3D structures from and Proteopedia for ANXA1:
1AIN (3D)        1BO9 (3D)        1QLS (3D)    

Explore the universe of human proteins at neXtProt for ANXA1: NX_P04083

Explore proteomics data for ANXA1 at MOPED

Post-translational modifications: 

  • Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in
    loss of the inhibitory activity1
  • Ubiquitination2 at Lys58, Lys166, Lys274
  • Glycosylation2 at Ser37
  • Modification sites at PhosphoSitePlus

  • See ANXA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000691.1  
    ENSEMBL proteins: 
     ENSP00000257497   ENSP00000412489   ENSP00000414013   ENSP00000366109  
    Reactome Protein details: P04083

    ANXA1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ANXA1
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    Novus Biologicals ANXA1 Proteins
    Novus Biologicals ANXA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ANXA1
    Cloud-Clone Corp. Proteins for ANXA1

    ANXA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANXA1
    R&D Systems Antibodies for ANXA1 (Annexin A1)
    Cell Signaling Technology (CST) Antibodies for ANXA1 
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    Abcam antibodies for ANXA1
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    LSBio Antibodies in human, mouse, rat for ANXA1

    ANXA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ANXA1
    Cloud-Clone Corp. CLIAs for ANXA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    ANXA: Annexins

    4 InterPro protein domains:
     IPR018502 Annexin_repeat
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR002388 AnnexinI

    Graphical View of Domain Structure for InterPro Entry P04083

    ProtoNet protein and cluster: P04083

    2 Blocks protein domains:
    IPB001464 Annexin
    IPB002388 Annexin type I signature


    UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    ANXA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANXA1_HUMAN, P04083
    Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
    protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

         Genatlas biochemistry entry for ANXA1:
    annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of
    the organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid
    feadback action in the hypothalamo-hypophysial system

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity ----
    GO:0005102receptor binding TAS10882119
    GO:0005198structural molecule activity IDA10908733
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
         
    ANXA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ANXA1:
     Decreased viability 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Anxa1):
     adipose tissue  cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     nervous system  skeleton  tumorigenesis 

    ANXA1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANXA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANXA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANXA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANXA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANXA1:
    hsa-mir-30a-5p (MIRT028650), hsa-mir-335-5p (MIRT018638), hsa-mir-26b-5p (MIRT030065), hsa-mir-196a-5p (MIRT000709)

    Block miRNA regulation of human, mouse, rat ANXA1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ANXA1
    SwitchGear 3'UTR luciferase reporter plasmidANXA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANXA1
    Predesigned siRNA for gene silencing in human, mouse, rat ANXA1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for ANXA1
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    GenScript: all cDNA clones in your preferred vector: ANXA1 (NM_000700)
    Sino Biological Human cDNA Clone for ANXA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANXA1_HUMAN, P04083: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity).
    Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of
    ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and
    alveolar macrophages (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular5
    cytosol4
    plasma membrane4
    endosome2
    mitochondrion2
    nucleus2
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001533cornified envelope IDA10908733
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS16130169

    ANXA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANXA1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Formyl peptide receptors bind formyl peptides and many other ligands0.00
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Spinal Cord Injury
    Spinal Cord Injury
    5Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ANXA1
        Ca, cAMP and Lipid Signaling

    4 BioSystems Pathways for ANXA1
        Integrated Breast Cancer Pathway
    Spinal Cord Injury
    Prostaglandin Synthesis and Regulation
    Integrated Pancreatic Cancer Pathway


    3 Reactome Pathways for ANXA1
        Formyl peptide receptors bind formyl peptides and many other ligands
    G alpha (q) signalling events
    G alpha (i) signalling events



    ANXA1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ANXA1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANXA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANXA1 (P040831, 2, 3 ENSP000002574974) via UniProtKB, MINT, STRING, and/or I2D (see all 310)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBB1O002132, 3, ENSP000002994024MINT-8247707 I2D: score=2 STRING: ENSP00000299402
    ENSG00000272333Q9UMN62, 3MINT-8247832 I2D: score=2 
    KMT2BQ9UMN62, 3MINT-8247832 I2D: score=2 
    C14orf1Q9UKR52, 3MINT-8247720 I2D: score=2 
    CCT7Q998322, 3MINT-8247753 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001780neutrophil homeostasis IMP--
    GO:0002674negative regulation of acute inflammatory response IEA--
    GO:0006928cellular component movement TAS10882119
    GO:0006954inflammatory response TAS10882119
    GO:0007049cell cycle ----

    ANXA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ANXA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ThiolutinBacterial RNA polymerase inhibitor[87-11-6]
    Heparin sodium saltAnticoagulant[9041-08-1]
    Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor[154303-05-6]
    RGDS peptideIntegrin binding sequence; inhibits integrin receptor function[91037-65-9]
    Ac2-26Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation[151988-33-9]

    1 HMDB Compound for ANXA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for ANXA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Hydrocortisone11beta-Hydroxycortisone (see all 16)50-23-7targetagonist1712816 17139284 11142771 17016423 8060156
    DexamethasoneDesametasone (see all 9)50-02-2targetagonist17644190 17076770 17158208 16883066
    Amcinonide-- 51022-69-6targetagonist17139284 17016423 7981624

    Selected Novoseek inferred chemical compound relationships for ANXA1 gene (see all 56)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hdmnkvldl 84.9 2 8818992 (1), 1793057 (1)
    phosphatidylserine 62.1 29 8179621 (3), 7627125 (1), 12744815 (1), 15381697 (1) (see all 16)
    phospholipid 59.7 33 8379935 (7), 2138536 (1), 1310621 (1), 8485141 (1) (see all 20)
    calcium 55 126 11142771 (6), 9299392 (5), 18283055 (4), 1469069 (3) (see all 58)
    arachidonic acid 49.2 16 2064175 (2), 8260938 (2), 2137129 (2), 12845669 (1) (see all 10)
    dexamethasone 45.3 54 8256657 (6), 12236584 (5), 17644190 (4), 14668092 (3) (see all 17)
    glyceraldehyde 3-phosphate 44.7 7 16220529 (1), 17268060 (1), 15274135 (1), 19899082 (1) (see all 7)
    geneticin 32.2 1 7764687 (1)
    phosphatidylcholine 30.4 17 16307464 (2), 12845669 (1), 7654693 (1), 1387325 (1) (see all 5)
    p-opc 30 7 16307464 (3), 18237543 (2)



    ANXA1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANXA1 gene: 
    NM_000700.1  

    Unigene Cluster for ANXA1:

    Annexin A1
    Hs.494173  [show with all ESTs]
    Unigene Representative Sequence: AK074480
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257497(uc004ajf.1) ENST00000468639 ENST00000456643 ENST00000415424
    ENST00000376911(uc004ajg.1) ENST00000495713 ENST00000489109 ENST00000491192

    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ANXA1
      QuantiFast Probe-based Assays in human, mouse, rat ANXA1

    Additional mRNA sequence: 

    AB451274.1 AB451401.1 AK023330.1 AK074480.1 AK296808.1 AK311684.1 BC001275.1 BC018683.1 
    BC034157.1 BC035993.1 BT019896.1 BT019916.1 BT019917.1 CR407684.1 X05908.1 

    Selected DOTS entries (see all 49):

    DT.95080391  DT.100890399  DT.95202652  DT.100765659  DT.100890413  DT.100890422  DT.100890394  DT.100890395 
    DT.121161786  DT.100890415  DT.95340497  DT.95223581  DT.92045136  DT.92466092  DT.100040129  DT.100890410 
    DT.100890409  DT.91793108  DT.91703452  DT.91949347  DT.121161854  DT.100890404  DT.92466082  DT.92466099 

    Selected AceView cDNA sequences (see all 1569):

    CD709026 BG748968 CA419768 CA414702 CB159233 CB134078 CB409715 AW439690 
    CB147659 BM762676 BQ228510 BE163625 AA360576 CB134806 AU137564 BQ962052 
    BQ775829 CA405627 BQ962446 CA443862 AU137423 AU135495 BM476344 BU684426 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:              -     -     -     -     -                 -           -                 -                             -                 -                     
    SP2:                                                        -           -                 -                             -                 -                     
    SP3:              -           -     -     -                 -           -                 -                             -                                       
    SP4:                                                                                      -                             -                                       
    SP5:                    -     -     -     -                 -           -                 -                                                                     


    ECgene alternative splicing isoforms for ANXA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ANXA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAAGATGT
    ANXA1 Expression
    About this image


    ANXA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 34) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             Line H9 (Naive)
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Cerebral Cortex
             Dorsal forebrain-like neurons
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Laryngeal Cartilage
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocytes Zeugopod Epiphyseal End
             Bone Marrow
    ANXA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANXA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.494173
        Pathway & Disease-focused RT2 Profiler PCR Array including ANXA1: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ANXA1
    OriGene qSTAR qPCR primer pairs in human, mouse for ANXA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANXA1
    QuantiTect SYBR Green Assays in human, mouse, rat ANXA1
    QuantiFast Probe-based Assays in human, mouse, rat ANXA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANXA1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anxa11 , 5 annexin A11, 5 86.61(n)1
    87.57(a)1
      19 (13.83 cM)5
    169521  NM_010730.21  NP_034860.21 
     203734285 
    chicken
    (Gallus gallus)
    Aves ANXA11 annexin A1 75.07(n)
    78.59(a)
      404271  NM_206906.1  NP_996789.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA16
    annexin A1
    76(a)
    1 ↔ 1
    2(47804835-47822960)
    African clawed frog
    (Xenopus laevis)
    Amphibia anxa1-prov2 annexin A1 77.96(n)    BC053786.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anxa1a2 annexin A1a 73.36(n)   334724  AY178793.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nex-23 Annexin 42(a)
    (best of 3)
      III(10397630-10399688)   --


    ENSEMBL Gene Tree for ANXA1 (if available)
    TreeFam Gene Tree for ANXA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANXA1 gene
    ANXA32  ANXA62  ANXA52  ANXA92  ANXA22  ANXA72  ANXA82  ANXA112  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA1 using alignment to 6 protein entries:     ANXA1_HUMAN (see all proteins):
    ANXA2    ANXA2P2    DKFZp686H02120    ANXA13    ANXA7    ANXA8
    ANXA11    ANXA3    ANXA4    ANXA5    ANXA8L2    ANXA6
    ANXA8L1    ANXA9    ANXA10

    ANXA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANXA1 (see all 449)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127652951,2
    C,F--75764783(+) TAGTGG/ACTTTC 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs23103121,2
    C,F,O,A,H--75764998(+) CAAAGC/AAAAAT 1 -- us2k124Minor allele frequency- A:0.19NA NS EA WA 2694
    rs1390908591,2
    --75765039(+) TTTTAC/TAAAAA 1 -- us2k10--------
    rs1423959281,2
    --75765093(+) AGGAAA/TGTTCC 1 -- us2k10--------
    rs37583551,2
    C,F,H--75765100(+) TTCCAA/GTAGTT 1 -- us2k15Minor allele frequency- G:0.02EA NS 1898
    rs1929154221,2
    --75765212(+) TATTAA/GAAAGT 1 -- us2k10--------
    rs785905931,2
    C--75765229(+) ACATCT/CGTCAA 1 -- us2k13Minor allele frequency- C:0.08CSA WA 121
    rs1851810361,2
    --75765234(+) TGTCAA/GGATCA 1 -- us2k10--------
    rs339429881,2
    C--75765264(+) ACTTA-/ACTTGT 1 -- us2k10--------
    rs1170381621,2
    F--75765351(+) GATTAG/CATGAT 1 -- us2k11Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for ANXA1 (75766673 - 75785309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ANXA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6561CNV Insertion18451855
    nsv526225CNV Gain19592680
    nsv519796CNV Gain19592680
    nsv893452CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANXA1
    DNA2.0 Custom Variant and Variant Library Synthesis for ANXA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151690    OMIM disorders: --

    Selected diseases for ANXA1 (see all 75):    
    About MalaCards
    brain edema    colon adenocarcinoma    oral cancer    uterine fibroid
    prostate adenocarcinoma    hairy cell leukemia    sarcoidosis    pulmonary sarcoidosis
    lung adenocarcinoma    psoriatic arthritis    stomach cancer    oral squamous cell carcinoma
    endocarditis    idiopathic pulmonary fibrosis    laryngeal squamous cell carcinoma    cystic fibrosis
    esophageal squamous cell carcinoma    pulmonary fibrosis    adenocarcinoma    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for ANXA1:
    Carcinoma

    ANXA1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ANXA1 gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 41.2 25 15447985 (3), 12242662 (2), 18297688 (2), 12679902 (2) (see all 17)
    adenocarcinoma lung 38.7 5 17351649 (2), 17974280 (1)
    inflammation 32.3 33 9796991 (3), 15962097 (3), 19104500 (2), 9831319 (1) (see all 21)
    premalignant 27 6 10448305 (1), 19351789 (1), 19101730 (1), 14695321 (1)
    tumors 24.8 58 16270603 (4), 19173988 (3), 17340616 (3), 18652761 (3) (see all 29)
    prostatic intraepithelial neoplasia 23.9 4 16324197 (2), 11801547 (1)
    colon adenocarcinoma 23.9 6 15526283 (3), 18541673 (2)
    oral cancer 21.1 6 18297688 (2), 20371204 (1), 12870656 (1)
    cancer 16.7 34 18663355 (4), 20215502 (2), 16324197 (2), 20371204 (1) (see all 15)
    metastasis 16.6 22 18535914 (3), 20353277 (3), 18776816 (3), 18223218 (2) (see all 11)

    Genetic Association Database (GAD): ANXA1
    Human Genome Epidemiology (HuGE) Navigator: ANXA1 (6 documents)

    Export disorders for ANXA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANXA1 gene, integrated from 10 sources (see all 550) (see top 10):
    (articles sorted by number of sources associating them with ANXA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PubMed id 2936963)1, 2, 3 Wallner B.P.... Pepinsky R.B. (Nature 1986)
    2. Crystal structure of human annexin I at 2.5-A resolution. (PubMed id 8453382)1, 2, 9 Weng X.... Huber R. (Protein Sci. 1993)
    3. Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PubMed id 16883066)1, 7, 9 Morand E.F....Yang Y.H. (Mediators Inflamm. 2006)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Phosphorylation of annexin I by TRPM7 channel-kinase. (PubMed id 15485879)1, 2 Dorovkov M.V. and Ryazanov A.G. (J. Biol. Chem. 2004)
    6. [Absence of evidence for the association of single nucleotide polymorphisms in Annexin A1 gene with type 2 diabetes in Chinese]. (PubMed id 15476183)1, 4 Dong Y....Luo M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Characterization of the annexin I gene and evaluation of its role in type 2 diabetes. (PubMed id 11574426)1, 4 Lindgren C.M....Groop L.C. (Diabetes 2001)
    9. NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit. (PubMed id 9915835)1, 2 Gao J.... Yan H. (J. Biol. Chem. 1999)
    10. Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. (PubMed id 8425544)1, 2 Arcone R.... Ciliberto G. (Eur. J. Biochem. 1993)
    11. Correlation of gene and protein structure of rat and human lipocortin I. (PubMed id 1832554)1, 2 Kovacic R.T.... Wallner B.P. (Biochemistry 1991)
    12. A dimeric form of lipocortin-1 in human placenta. (PubMed id 2532504)1, 2 Pepinsky R.B.... O'Brine-Greco B. (Biochem. J. 1989)
    13. Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C. (PubMed id 2457390)1, 2 Varticovski L.... Pepinsky R.B. (Biochemistry 1988)
    14. Characterization by tandem mass spectrometry of structural modifications in proteins. (PubMed id 3303336)1, 2 Biemann K. and Scoble H.A. (Science 1987)
    15. Calcium-induced intracellular cross-linking of lipocortin I by tissue transglutaminase in A431 cells. Augmentation by membrane phospholipids. (PubMed id 1670773)1, 9 Ando Y....Kannagi R. (J. Biol. Chem. 1991)
    16. Annexin-I overexpression is associated with tumour progression and independently predicts inferior disease-specific and metastasis-free survival in urinary bladder urothelial carcinoma. (PubMed id 20025479)1, 9 Li C.F....Wu T.F. (Pathology 2010)
    17. Annexin A1 expression and its prognostic significance in human breast cancer. (PubMed id 20353277)1, 9 Wang L.P....Chang G.Q. (Neoplasma 2010)
    18. Loss of annexin A1 expression in breast cancer progression. (PubMed id 18776816)1, 9 Cao Y....Albarracin C.T. (amp 2008)
    19. Annexin A1 subcellular expression in laryngeal squamous cell carcinoma. (PubMed id 19076685)1, 9 Alves V.A....Zago M.A. (Histopathology 2008)
    20. MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers. (PubMed id 18663355)1, 9 Luthra R....Albarracin C.T. (Oncogene 2008)
    21. Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors. (PubMed id 16675446)1, 9 Babbin B.A....Nusrat A. (J. Biol. Chem. 2006)
    22. Decreased annexin I expression in prostatic adenocarcinoma and in high-grade prostatic intraepithelial neoplasia. (PubMed id 16324197)1, 9 Patton K.T....Yang X.J. (Histopathology 2005)
    23. Dexamethasone induces the secretion of annexin I in immature lymphoblastic cells by a calcium-dependent mechanism. (PubMed id 12236584)1, 9 Castro-Caldas M....Lopes M.C. (Mol. Cell. Biochem. 2002)
    24. Expression of annexin I in freshly isolated human epidermal cells and in cultured keratinocytes. (PubMed id 8060156)7, 9 Serres M....Schmitt D. (Arch. Dermatol. Res. 1994)
    25. Loss of annexin A1 disrupts normal prostate glandular structure by inducing autocrine IL-6 signaling. (PubMed id 19351789)1, 9 Inokuchi J....Ornstein D.K. (Carcinogenesis 2009)
    26. Nuclear localization of annexin A1 is a prognostic factor in oral squamous cell carcinoma. (PubMed id 18297688)1, 9 Lin C.Y....Kuo M.Y. (J Surg Oncol 2008)
    27. Truncation of annexin A1 is a regulatory lever for linking epidermal growth factor signaling with cytosolic phospholipase A2 in normal and malignant squamous epithelial cells. (PubMed id 17932043)1, 9 Sakaguchi M....Huh N.H. (J. Biol. Chem. 2007)
    28. Expression of annexin A1 in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome. (PubMed id 16899607)1, 9 Wang K.L....Albarracin C.T. (Clin. Cancer Res. 2006)
    29. 17beta-estradiol promotes the synthesis and the secretion of annexin I in the CCRF-CEM human cell line. (PubMed id 11759108)1, 9 Castro-Caldas M....Lopes M.C. (Mediators Inflamm. 2001)
    30. Decreased expression of annexin A1 is correlated with breast cancer development and progression as determined by a tissue microarray analysis. (PubMed id 16949910)1, 9 Shen D....Goodglick L. (Hum. Pathol. 2006)
    31. Membrane expression of annexin I is enhanced by calcium and TPA in cultured human keratinocytes. (PubMed id 11142771)7, 9 Sato-Matsumura K.C....Koizumi H. (Arch. Dermatol. Res. 2000)
    32. Annexin-I as a potential target for green tea extract induced actin remodeling. (PubMed id 17019707)1, 9 Xiao G.S....Rao J. (Int. J. Cancer 2007)
    33. In vitro and in vivo studies on CCR10 regulation by Annexin A1. (PubMed id 16460738)1, 9 Rodrigues-Lisoni F.C....Solito E. (FEBS Lett. 2006)
    34. Differentiation of human colon adenocarcinoma cells alters the expression and intracellular localization of annexins A1, A2, and A5. (PubMed id 15526283)1, 9 GuzmA!n-ArA!nguez A....Lizarbe M.A. (J. Cell. Biochem. 2005)
    35. Enhanced neutrophil expression of annexin-1 in coronary artery disease. (PubMed id 19850308)1, 9 SAorndahl E....Jonasson L. (Metab. Clin. Exp. 2010)
    36. Identification of annexin A1 as a novel substrate for E6AP-mediated ubiquitylation. (PubMed id 19204938)1, 9 Shimoji T.... Shoji I. (J. Cell. Biochem. 2009)
    37. Decreased expression of annexin A1 during the progression of cervical neoplasia. (PubMed id 18652761)1, 9 Wang L.D....Li P.L. (J. Int. Med. Res. 2008)
    38. Involvement of annexin I in the dexamethasone-mediated upregulation of A549 cells phagocytosis of apoptotic eosinophils. (PubMed id 17644190)7, 9 Wang C....Liu R.Y. (Immunol. Lett. 2007)
    39. Calcium-dependent binding of S100C to the N-terminal domain of annexin I. (PubMed id 8557678)1, 9 Mailliard W.S....Schlaepfer D.D. (J. Biol. Chem. 1996)
    40. Decreased expression of Annexin A1 correlates with pathologic differentiation grade in oral squamous cell carcinoma. (PubMed id 18673418)1, 9 Zhang L....Zhang Z.Y. (amp 2009)
    41. Down-regulation of plasma membranous Annexin A1 protein expression in premalignant and malignant lesions of the oral cavity: correlation with epithelial differentiation. (PubMed id 19101730)1, 9 Nomura H....Tanzawa H. (J. Cancer Res. Clin. Oncol. 2009)
    42. Cell surface externalization of annexin A1 as a failsafe mechanism preventing inflammatory responses during secondary necrosis. (PubMed id 20007579)1, 9 Blume K.E....Lauber K. (J. Immunol. 2009)
    43. Annexin-1 downregulation in thyroid cancer correlates to the degree of tumor differentiation. (PubMed id 16627980)1, 9 Petrella A....Parente L. (amp 2006)
    44. Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera. (PubMed id 18794547)1, 9 Qiu J....Hanash S.M. (J. Clin. Oncol. 2008)
    45. Requirement for annexin A1 in plasma membrane repair. (PubMed id 16984915)1, 9 McNeil A.K....McNeil P.L. (J. Biol. Chem. 2006)
    46. Comprehensive characterization of annexin I alterations in esophageal squamous cell carcinoma. (PubMed id 15447985)1, 9 Hu N....Taylor P.R. (Clin. Cancer Res. 2004)
    47. Subcellular localization of S100A11 (S100C) in LLC-PK1 renal cells: Calcium- and protein kinase c-dependent association of S100A11 with S100B and vimentin intermediate filaments. (PubMed id 12645011)1, 9 Bianchi R....Donato R. (Microsc. Res. Tech. 2003)
    48. Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model. (PubMed id 12165536)1, 9 Perretti M....Pitzalis C. (J. Immunol. 2002)
    49. Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells. (PubMed id 20308542)1, 9 de Graauw M....van de Water B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    50. Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. (PubMed id 19104500)1, 9 Perretti M. and D'Acquisto F. (Nat. Rev. Immunol. 2009)
    51. The confluence-dependent interaction of cytosolic phospholipase A2-alpha with annexin A1 regulates endothelial cell prostaglandin E2 generation. (PubMed id 17873281)1, 9 Herbert S.P....Walker J.H. (J. Biol. Chem. 2007)
    52. Translocation of annexin I from cellular membrane to the nuclear membrane in human esophageal squamous cell carcinoma. (PubMed id 12679902)1, 9 Liu Y....Zhao X.H. (World J. Gastroenterol. 2003)
    53. A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. (PubMed id 10882119)1, 9 Walther A....Gerke V. (Mol. Cell 2000)
    54. Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damage. (PubMed id 20163912)1, 9 Nair S....Lim L.H. (Cancer Lett. 2010)
    55. Attenuated translocation of group IVa phospholipase A2 and up-regulated annexin-1 synthesis by glucocorticoid blocks beta 2-integrin adhesion in neutrophils. (PubMed id 17971499)1, 9 Meliton A.Y....Leff A.R. (J. Leukoc. Biol. 2008)
    56. Heterogeneity and timing of translocation and membrane-mediated assembly of different annexins. (PubMed id 18164291)1, 9 Skrahina T....Schultz C. (Exp. Cell Res. 2008)
    57. Overexpression of annexin a1 induced by terephthalic acid calculi in rat bladder cancer. (PubMed id 17994624)1, 9 Cui L....Wang X. (Proteomics 2007)
    58. [Expression of annexin I in human pancreatic cancer and the influence of its down-regulation on biology of this cancer]. (PubMed id 18396684)1, 9 Liu Q....Zhao P. (Zhonghua Zhong Liu Za Zhi 2007)
    59. Annexin 1: differential expression in tumor and mast cells in human larynx cancer. (PubMed id 17340616)1, 9 Silistino-Souza R....Oliani S.M. (Int. J. Cancer 2007)
    60. Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3. (PubMed id 16530434)1, 9 Gil C.D....Oliani S.M. (Cell Biol. Int. 2006)
    61. The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells. (PubMed id 16741918)1, 9 Hsiang C.H....Ornstein D.K. (Prostate 2006)
    62. Glucocorticoid upregulation of the annexin-A1 receptor in leukocytes. (PubMed id 16973129)1, 9 Sawmynaden P. and Perretti M. (Biochem. Biophys. Res. Commun. 2006)
    63. Mutation finding in patients with dysferlin deficiency and role of the dysferlin interacting proteins annexin A1 and A2 in muscular dystrophies. (PubMed id 16100712)1, 9 Cagliani R.... Comi G.P. (Hum. Mutat. 2005)
    64. Down-regulation of the anti-inflammatory protein annexin A1 in cystic fibrosis knock-out mice and patients. (PubMed id 16014420)1, 9 Bensalem N....Edelman A. (amp 2005)
    65. Annexin-I expression modulates drug resistance in tumor cells. (PubMed id 14733945)1, 9 Wang Y....Georges E. (Biochem. Biophys. Res. Commun. 2004)
    66. Annexin 1 and neutrophil apoptosis. (PubMed id 15157173)1, 9 Perretti M. and Solito E. (Biochem. Soc. Trans. 2004)
    67. An annexin 1 (ANXA1)-derived peptide inhibits prototype antigen-driven human T cell Th1 and Th2 responses in vitro. (PubMed id 11468004)1, 9 Kamal A.M....Corrigan C.J. (Clin. Exp. Allergy 2001)
    68. Partial mediation of glucocorticoid antiproliferative effects by lipocortins. (PubMed id 8955167)1, 9 Almawi W.Y....Strom T.B. (J. Immunol. 1996)
    69. Hydrocortisone inhibits rat basophilic leukemia cell mediator release induced by neutrophil-derived histamine releasing activity as well as by anti-IgE. (PubMed id 1712816)7, 9 White M.V....Kaliner M. (J. Immunol. 1991)
    70. Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. (PubMed id 2138016)1, 9 Blackwood R.A. and Ernst J.D. (Biochem. J. 1990)
    71. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    72. Annexin A1 on the surface of early apoptotic cells suppresses CD8+ T cell immunity. (PubMed id 23638088)1 Weyd H....Krammer P.H. (PLoS ONE 2013)
    73. Annexin A1 is regulated by domains cross-talk through post-translational phosphorylation and SUMOYlation. (PubMed id 23727357)1 Caron D....Faure R.L. (Cell. Signal. 2013)
    74. Low Annexin A1 expression predicts benefit from induction chemotherapy in oral cancer patients with moderate or poor pathologic differentiation grade. (PubMed id 23786757)1 Zhu D.W....Zhong L.P. (BMC Cancer 2013)
    75. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. (PubMed id 23241962)1 Leoni G....Nusrat A. (J. Clin. Invest. 2013)
    76. Annexin A1 is a biomarker of T-tubular repair in skeletal muscle of nonmyopathic patients undergoing statin therapy. (PubMed id 23413360)1 Voigt T....Draeger A. (FASEB J. 2013)
    77. Down-regulation of annexin A1 in the urothelium decreases cell survival after bacterial toxin exposure. (PubMed id 23376147)1 Monastyrskaya K....Burkhard F.C. (J. Urol. 2013)
    78. Overexpression of ANXA1 in penile carcinomas positive for high-risk HPVs. (PubMed id 23341933)1 Calmon M.F....Rahal P. (PLoS ONE 2013)
    79. Annexin A1 down-regulation in oral squamous cell carcinoma correlates to pathological differentiation grade. (PubMed id 23403091)1 Zhu D.W....Zhong L.P. (Oral Oncol. 2013)
    80. Annexin A1: A new immunohistological marker of cholangiocarcinoma. (PubMed id 23674846)1 Hongsrichan N....Pinlaor S. (World J. Gastroenterol. 2013)
    81. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    82. Identification of Annexin A1 interacting proteins in chronic myeloid leukemia KCL22 cells. (PubMed id 23754495)1 Colavita I....Salvatore F. (Proteomics 2013)
    83. Expression of annexin-A1 and galectin-1 anti-inflammatory proteins and mRNA in chronic gastritis and gastric cancer. (PubMed id 23431236)1 Jorge Y.C....Silva A.E. (Mediators Inflamm. 2013)
    84. Annexin-A1 protein and its relationship to cortisol in human saliva. (PubMed id 23017499)1 Fowkes R.C....Renshaw D. (Psychoneuroendocrinology 2013)
    85. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    86. Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications. (PubMed id 23277546)1 Cristante E....Solito E. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    87. Regulation of lung fibroblast activation by annexin A1. (PubMed id 22777765)1 Jia Y....Yang Y.H. (J. Cell. Physiol. 2013)
    88. Smooth muscle cells in human atherosclerosis: proteomic profiling reveals differences in expression of Annexin A1 and mitochondrial proteins in carotid disease. (PubMed id 23154128)1 Viiri L.E....Monaco C. (J. Mol. Cell. Cardiol. 2013)
    89. Endothelial microparticle uptake in target cells is annexin I/phosphatidylserine receptor dependent and prevents apoptosis. (PubMed id 22701020)1 Jansen F....Werner N. (Arterioscler. Thromb. Vasc. Biol. 2012)
    90. Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin. (PubMed id 22792315)1 Tcatchoff L....Sandvig K. (PLoS ONE 2012)
    91. Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression. (PubMed id 22773844)1 Pin A.L....Huot J. (J. Biol. Chem. 2012)
    92. Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling. (PubMed id 22610094)1 Bena S....Flower R.J. (J. Biol. Chem. 2012)
    93. [Hypoxia upregulates the expression of annexin A1 in lung adenocarcinoma a549 cells]. (PubMed id 22613333)1 Hu Z....Guan L. (Zhongguo Fei Ai Za Zhi 2012)
    94. Up-regulation of Annexin-A1 and lipoxin A(4) in individuals with ulcerative colitis may promote mucosal homeostasis. (PubMed id 22723974)1 Vong L....Wallace J.L. (PLoS ONE 2012)
    95. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    96. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    97. Annexin A1 mediates the anti-inflammatory effects during the granulocytic differentiation process in all-trans retinoic acid-treated acute promyelocytic leukemic cells. (PubMed id 22378018)1 Tsai W.H....Hsu H.C. (J. Cell. Physiol. 2012)
    98. Quantitative proteomic analysis identifying three annexins as lymph node metastasis-related proteins in lung adenocarcinoma. (PubMed id 21132403)1 Liu Y.F....Chen Z.C. (Med. Oncol. 2012)
    99. Quantitative proteomics reveal ATM kinase-dependent exchange in DNA damage response complexes. (PubMed id 22909323)1 Choi S....Bakkenist C.J. (J. Proteome Res. 2012)
    100. Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28. (PubMed id 21903368)1 Wong P.F....AbuBakar S. (Phytomedicine 2012)
    101. The role of annexin A1 in expression of matrix metalloproteinase-9 and invasion of breast cancer cells. (PubMed id 22640735)1 Kang H....Jang S.W. (Biochem. Biophys. Res. Commun. 2012)
    102. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    103. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    104. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (Mol. Cell. Biochem. 2012)
    105. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)
    106. Annexin A1 is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal-regulated kinase/integrin beta-1-binding protein 1 pathway. (PubMed id 22736399)1 Cheng T.Y....Kuo M.L. (Cancer 2012)
    107. Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic &quot;find-me&quot; signal. (PubMed id 22116825)1 Blume K.E....Lauber K. (J. Immunol. 2012)
    108. Annexin A1 N-terminal derived peptide Ac2-26 stimulates fibroblast migration in high glucose conditions. (PubMed id 23029153)1 Bizzarro V....Petrella A. (PLoS ONE 2012)
    109. PKCI/ promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. (PubMed id 22304920)1 Lau E....Ronai Z.A. (Cell 2012)
    110. Suppression of MIP-2 or IL-8 production by annexins A1 and A4 during coculturing of macrophages with late apoptotic human peripheral blood neutrophils. (PubMed id 22056994)1 Iwasa T....Kobayashi Y. (Biochim. Biophys. Acta 2012)
    111. Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients. (PubMed id 22929401)1 Biaoxue R....Min Z. (amp 2012)
    112. Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes. (PubMed id 21836070)1 Nadkarni S....Perretti M. (Arterioscler. Thromb. Vasc. Biol. 2011)
    113. Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-I_B: implication in breast cancer metastasis. (PubMed id 21383699)1 Bist P....Lim L.H. (Oncogene 2011)
    114. Identification of annexin A1 as a proinvasive and prognostic factor for lung adenocarcinoma. (PubMed id 21365324)1 Liu Y.F....Chen Z.C. (amp 2011)
    115. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    116. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    117. Propofol inhibits the activation of p38 through up-regulating the expression of annexin A1 to exert its anti-inflammation effect. (PubMed id 22164217)1 Tang J....Liu Y. (PLoS ONE 2011)
    118. Annexin A1 expression in atherosclerotic carotid plaques and its relationship with plaque characteristics. (PubMed id 21195640)1 Cheuk B.L. and Cheng S.W. (Eur J Vasc Endovasc Surg 2011)
    119. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    120. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    121. Proteomics analysis of starved cells revealed Annexin A1 as an important regulator of autophagic degradation. (PubMed id 21420379)1 Kang J.H....Yin X.M. (Biochem. Biophys. Res. Commun. 2011)
    122. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    123. Down-regulation of annexin A1 and A2 protein expression in intestinal-type sinonasal adenocarcinomas. (PubMed id 20970165)1 Rodrigo J.P....Hermsen M. (Hum. Pathol. 2011)
    124. Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. (PubMed id 21398608)1 Brancaleone V....Perretti M. (J. Immunol. 2011)
    125. Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch. (PubMed id 21412170)1 Waddell L.B....Cooper S.T. (J. Neuropathol. Exp. Neurol. 2011)
    126. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)
    127. Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling. (PubMed id 21254404)1 Pupjalis D....Rescher U. (EMBO Mol Med 2011)
    128. Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. (PubMed id 20930115)1 Khau T....Stewart A.G. (FASEB J. 2011)
    129. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    130. The role of annexins I, II and IV in tumor development, progression and metastasis of human penile squamous cell carcinomas. (PubMed id 20602103)1 Protzel C....Giebel J. (World J Urol 2011)
    131. Regulation of vascular endothelial growth factor-induced endothelial cell migration by LIM kinase 1-mediated phosphorylation of annexin 1. (PubMed id 20061392)1 CA'tAc M.C....Huot J. (J. Biol. Chem. 2010)
    132. Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. (PubMed id 20558817)1 Yazid S....Flower R.J. (Arterioscler. Thromb. Vasc. Biol. 2010)
    133. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    134. Up-regulation of hnRNP A1, Ezrin, tubulin I^-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer. (PubMed id 20872967)1 He Z.Y....Wang J. (World J. Gastroenterol. 2010)
    135. A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration. (PubMed id 20679535)1 Williams S.L....Khew-Goodall Y. (J. Immunol. 2010)
    136. Expression of genes that encode the annexin-1 and galectin-1 proteins in nasal polyposis and their modulation by glucocorticoid. (PubMed id 20549082)1 Fernandes A.M....Anselmo-Lima W.T. (Braz J Otorhinolaryngol 2010)
    137. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (Nature 2010)
    138. Differential roles of Annexin A1 (ANXA1/lipocortin-1/lipomodulin) and thioredoxin binding protein-2 (TBP-2/VDUP1/TXNIP) in glucocorticoid signaling of HTLV-I-transformed T cells. (PubMed id 20398702)1 Chen Z....Yodoi J. (Immunol. Lett. 2010)
    139. Nuclear localization of annexin A1 correlates with advanced disease and peritoneal dissemination in patients with gastric carcinoma. (PubMed id 20665809)1 Zhu F....Cao J. (Anat Rec (Hoboken) 2010)
    140. Increased expression of annexin A1 is correlated with K-ras mutation in colorectal cancer. (PubMed id 21127395)1 Su N....Sun Y.P. (Tohoku J. Exp. Med. 2010)
    141. [Expression of annexin A1 (ANXA1) and A2 (ANXA2) and its significance in benign and malignant lesions of gallbladder]. (PubMed id 21122411)1 Yang L.P....Miao X.Y. (Zhonghua Zhong Liu Za Zhi 2010)
    142. Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia. (PubMed id 20962261)1 McArthur S....Solito E. (J. Immunol. 2010)
    143. Ubiquitination and SUMOylation of annexin A1 and helicase activity. (PubMed id 20359522)1 Hirata F....Hirata A. (Biochim. Biophys. Acta 2010)
    144. Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. (PubMed id 20713499)1 Huang J....Smoller J.W. (Am J Psychiatry 2010)
    145. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    146. Annexin-1 downregulation is associated with clinical outcome in Chinese patients with hilar cholangiocarcinoma. (PubMed id 20924191)1 Wang D....Yu G. (Eur Surg Res 2010)
    147. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    148. Annexin A1 attenuates EMT and metastatic potential in breast cancer. (PubMed id 20821804)1 Maschler S....Beug H. (EMBO Mol Med 2010)
    149. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    150. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. (PubMed id 19738201)1 Humphries J.D....Humphries M.J. (Sci Signal 2009)
    151. Identification of annexin 1 as a PU.1 target gene in leukemia cells. (PubMed id 19428102)1 Iseki Y....Takahashi S. (Leuk. Res. 2009)
    152. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. (PubMed id 19394292)1 Ouyang J....Gill G. (Mol. Cell 2009)
    153. Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival. (PubMed id 19767728)1 Schittenhelm J....Beschorner R. (Mod. Pathol. 2009)
    154. Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics. (PubMed id 19289595)1 Dong H.Y....Tugulea S. (Am. J. Clin. Pathol. 2009)
    155. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    156. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    157. Annexin-1 regulates growth arrest induced by high levels of estrogen in MCF-7 breast cancer cells. (PubMed id 19208747)1 Ang E.Z....Lim L.H. (Mol. Cancer Res. 2009)
    158. Common genetic variation and the control of HIV-1 in humans. (PubMed id 20041166)4 Fellay J....Goldstein D.B. (PLoS Genet. 2009)
    159. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. (PubMed id 19596235)1 Svendsen J.M.... Harper J.W. (Cell 2009)
    160. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    161. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    162. Expression of Annexin-1 in patients with endometriosis. (PubMed id 18706208)1 Li C.Y....Zhou H.M. (Chin. Med. J. 2008)
    163. Identification of annexin 1 as a novel autoantigen in acute exacerbation of idiopathic pulmonary fibrosis. (PubMed id 18566442)1 Kurosu K....Kuriyama T. (J. Immunol. 2008)
    164. Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. (PubMed id 18594025)1 Dalli J....Perretti M. (Blood 2008)
    165. Interaction proteomics of the HMGA chromatin architectural factors. (PubMed id 18850631)1 Sgarra R....Manfioletti G. (Proteomics 2008)
    166. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    167. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (Sci Signal 2008)
    168. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
    169. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. (PubMed id 17255364)1 Lapierre L.A....Goldenring J.R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007)
    170. Annexin-1 modulates T-cell activation and differentiation. (PubMed id 17008549)1 D'Acquisto F....Perretti M. (Blood 2007)
    171. Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation. (PubMed id 17317721)1 Gavins F.N....Perretti M. (FASEB J. 2007)
    172. [Epstein-Barr virus-encoded latent membrane protein 1 mediates serine-phosphorylation of annexin I by activating protein kinase C]. (PubMed id 17626739)1 Yan G.R....Cao Y. (Ai Zheng 2007)
    173. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    174. Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3. (PubMed id 17681950)1 Vong L....Perretti M. (J. Biol. Chem. 2007)
    175. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    176. Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages. (PubMed id 17372018)1 Scannell M....Maderna P. (J. Immunol. 2007)
    177. Annexin 1: the new face of an old molecule. (PubMed id 17215481)1 Lim L.H. and Pervaiz S. (FASEB J. 2007)
    178. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    179. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)
    180. Proteomic analysis of the cellular responses induced in uninfected immune cells by cell-expressed X4 HIV-1 envelope. (PubMed id 17676665)1 Molina L....Biard-Piechaczyk M. (Proteomics 2007)
    181. Expression and externalization of annexin 1 in the adrenal gland: structure and function of the adrenal gland in annexin 1-null mutant mice. (PubMed id 17158208)7 Davies E....Christian H.C. (Endocrinology 2007)
    182. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    183. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    184. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    185. Proteolytic cleavage of annexin 1 by human leukocyte elastase. (PubMed id 17023068)1 Rescher U....Gerke V. (Biochim. Biophys. Acta 2006)
    186. Time-specific effects of perinatal glucocorticoid treatment on anterior pituitary morphology, annexin 1 expression and adrenocorticotrophic hormone secretion in the adult female rat. (PubMed id 17076770)7 John C.D....Buckingham J.C. (J. Neuroendocrinol. 2006)
    187. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    188. Annexin1 regulates the erythroid differentiation through ERK signaling pathway. (PubMed id 15883023)1 Huo X.F. and Zhang J.W. (Biochem. Biophys. Res. Commun. 2005)
    189. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    190. Localization of annexins I, II, IV and VII in whole prostate sections from radical prostatectomy patients. (PubMed id 15944914)1 Lehnigk U....Giebel J. (Histol. Histopathol. 2005)
    191. Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. (PubMed id 16130169)1 Bruneel A....Baudin B. (Proteomics 2005)
    192. Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry. (PubMed id 16226712)1 Niture S.K....Srivenugopal K.S. (Biochem. Biophys. Res. Commun. 2005)
    193. Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells. (PubMed id 15168732)1 Cicek M....Casey G. (amp 2004)
    194. Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. (PubMed id 15161933)1 Meek S.E....Piwnica-Worms H. (J. Biol. Chem. 2004)
    195. Specific association of annexin 1 with plasma membrane-resident and internalized EGF receptors mediated through the protein core domain. (PubMed id 15581623)1 Radke S....Rescher U. (FEBS Lett. 2004)
    196. Macrophage surface expression of annexins I and II in the phagocytosis of apoptotic lymphocytes. (PubMed id 15064349)1 Fan X....Schlegel R.A. (Mol. Biol. Cell 2004)
    197. Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methods. (PubMed id 15047060)1 Bernhard O.K....Sheil M.M. (J. Am. Soc. Mass Spectrom. 2004)
    198. An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family. (PubMed id 15187149)1 Ernst S....Rescher U. (J. Immunol. 2004)
    199. Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. (PubMed id 14506282)1 Lennon N.J....Brown R.H. (J. Biol. Chem. 2003)
    200. Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. (PubMed id 12689596)1 Arur S....Han D.K. (Dev. Cell 2003)
    201. The surface receptor is involved in annexin I-stimulated insulin secretion in MIN6N8a cells. (PubMed id 12859969)1 Won J.H....Park Y.M. (Biochem. Biophys. Res. Commun. 2003)
    202. Gene expression profiling of alcoholic liver disease in the baboon (Papio hamadryas) and human liver. (PubMed id 14633604)1 Seth D....Haber P.S. (Am. J. Pathol. 2003)
    203. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    204. Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes. (PubMed id 10908733)1 Lee C.H....Steinert P.M. (FEBS Lett. 2000)
    205. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. (PubMed id 10512675)1 Manda R.... Yokota J. (Genomics 1999)
    206. Lipocortin 1 co-associates with cytokeratins 8 and 18 in A549 cells via the N-terminal domain. (PubMed id 9459484)1 Croxtall J.D....Flower R. (Biochim. Biophys. Acta 1998)
    207. A BC200-derived element and Z-DNA as structural markers in annexin I genes: relevance to Alu evolution and annexin tetrad formation. (PubMed id 8587144)1 Morgan R.O. and FernA!ndez M.P. (J. Mol. Evol. 1995)
    208. Annexin 1 regulation in human epidermal cells. (PubMed id 7981624)7 Serres M....Schmitt D. (Cell. Mol. Biol. (Noisy-le-grand) 1994)
    209. Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. (PubMed id 1602151)1 Dawson S.J. and White L.A. (J. Infect. 1992)
    210. Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor. (PubMed id 1374236)1 Ye R.D....Cochrane C.G. (Biochem. Biophys. Res. Commun. 1992)
    211. Diversity in the lipocortin/calpactin family. (PubMed id 2971450)1 Crompton M.R....Crumpton M.J. (Cell 1988)
    212. Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein. (PubMed id 2967291)1 Kaplan R.... Haigler H.T. (J. Biol. Chem. 1988)
    213. Chromosomal localization of the human genes for lipocortin I and lipocortin II. (PubMed id 2969496)1 Huebner K....Wallner B.P. (Oncogene Res. 1988)
    214. Annexin I degradation in bronchoalveolar lavage fluids from healthy smokers: a possible mechanism of inflammation. (PubMed id 9796991)9 Vishwanatha J.K....Floreani A. (Clin. Cancer Res. 1998)
    215. Effects of profilin-annexin I association on some properties of both profilin and annexin I: modification of the inhibitory activity of profilin on actin polymerization and inhibition of the self-association of annexin I and its interactions with liposomes. (PubMed id 9187254)9 Alvarez-Martinez M.T....Sri Widada J. (Biochim. Biophys. Acta 1997)
    216. [Expression of annexin I in different histological types of carcinomas]. (PubMed id 17974280)9 Xue L.Y....LA1 N. (Zhonghua Zhong Liu Za Zhi 2007)
    217. Novel role of HDAC inhibitors in AML1/ETO AML cells: activation of apoptosis and phagocytosis through induction of annexin A1. (PubMed id 17464329)9 Tabe Y....Konopleva M. (Cell Death Differ. 2007)
    218. Absence of annexin I expression in B-cell non-Hodgkin's lymphomas and cell lines. (PubMed id 15070421)9 Vishwanatha J.K....Gopalakrishnan V.K. (BMC Cancer 2004)
    219. Translocation of annexin I to plasma membranes and phagosomes in human neutrophils upon stimulation with opsonized zymosan: possible role in phagosome function. (PubMed id 8645229)9 Kaufman M....Levy R. (Biochem. J. 1996)
    220. Expression of human recombinant lipocortin I in a wheat-germ cell-free system and Xenopus oocytes. Lipocortin is not secreted. (PubMed id 1826832)9 Frey B.M....Trachsel H. (Biochem. J. 1991)
    221. Purification of annexin I and annexin II from human placental membranes by high-performance liquid chromatography. (PubMed id 1422205)9 Moore K.G....Sartorelli A.C. (Protein Expr. Purif. 1992)
    222. Green tea induces annexin-I expression in human lung adenocarcinoma A549 cells: involvement of annexin-I in actin remodeling. (PubMed id 17351649)9 Lu Q.Y....Rao J.Y. ( a journal of technical methods and pathology 2007)
    223. PKCdelta-dependent cleavage and nuclear translocation of annexin A1 by phorbol 12-myristate 13-acetate. (PubMed id 14519120)9 Kim Y.S....Na D.S. (Eur. J. Biochem. 2003)
    224. Degradation of annexin I in bronchoalveolar lavage fluid from patients with cystic fibrosis. (PubMed id 9448053)9 Tsao F.H....Hu J. (Am. J. Respir. Cell Mol. Biol. 1998)
    225. Annexin I-mediated vesicular aggregation: mechanism and role in human neutrophils. (PubMed id 1385975)9 Meers P....Tauber A.I. (Biochemistry 1992)
    226. Tissue microarray analysis reveals strong clinical evidence for a close association between loss of annexin A1 expression and nodal metastasis in gastric cancer. (PubMed id 18535914)9 Yu G....Xie K. (amp 2008)
    227. Expression, subcellular localization and phosphorylation status of annexins 1 and 5 in human pituitary adenomas and a growth hormone-secreting carcinoma. (PubMed id 14678296)9 Mulla A....Buckingham J.C. (Clin. Endocrinol. (Oxf) 2004)
    228. Identification of novel biomarkers in pediatric primitive neuroectodermal tumors and ependymomas by proteome-wide analysis. (PubMed id 17549010)9 de Bont J.M....Pieters R. (J. Neuropathol. Exp. Neurol. 2007)
    229. Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. (PubMed id 16278303)9 Hayhoe R.P....Perretti M. (Blood 2006)
    230. Annexin A1 expression in nasopharyngeal carcinoma correlates with squamous differentiation. (PubMed id 16270603)9 Rodrigo J.P....Herrero A. (Am J Rhinol 2005)
    231. Annexin 1: more than an anti-phospholipase protein. (PubMed id 15060718)9 Parente L. and Solito E. (Inflamm. Res. 2004)
    232. Annexin A1 down-regulation in head and neck cancer is associated with epithelial differentiation status. (PubMed id 14695321)9 Garcia Pedrero J.M....Rodrigo J.P. (Am. J. Pathol. 2004)
    233. Annexin I and dexamethasone effects on phospholipase and cyclooxygenase activity in human synoviocytes. (PubMed id 11132768)9 Sampey A.V....Morand E.F. (Mediators Inflamm. 2000)
    234. Annexin I surface binding sites and their regulation on human fibroblast-like synoviocytes. (PubMed id 11083278)9 Sampey A.V....Morand E.F. (Arthritis Rheum. 2000)
    235. Annexin 1 binds to U937 monocytic cells and inhibits their adhesion to microvascular endothelium: involvement of the alpha 4 beta 1 integrin. (PubMed id 10903766)9 Solito E....Weksler B.B. (J. Immunol. 2000)
    236. Regulation of annexin I-dependent aggregation of phospholipid vesicles by protein kinase C. (PubMed id 8379935)9 Johnstone S.A....Waisman D.M. (Biochem. J. 1993)
    237. Lipocortin-I inhibits the synthesis and release of prolactin from human decidual cells: evidence for autocrine/paracrine regulation by lipocortin-I. (PubMed id 1824932)9 Pihoker C....Handwerger S. (Endocrinology 1991)
    238. Identification of novel nasopharyngeal carcinoma biomarkers by laser capture microdissection and proteomic analysis. (PubMed id 18223218)9 Cheng A.L....Xiao Z.Q. (Clin. Cancer Res. 2008)
    239. [In vivo effect of annexin I down-regulation on the growth of human pancreatic cancer in nude mice]. (PubMed id 19173988)9 Liu Q....Zhao P. (Zhonghua Zhong Liu Za Zhi 2008)
    240. Kinase-dependent regulation of the secretion of thyrotrophin and luteinizing hormone by glucocorticoids and annexin 1 peptides. (PubMed id 12969239)9 John C.D....Buckingham J.C. (J. Neuroendocrinol. 2003)
    241. Annexin I is a stress protein induced by heat, oxidative stress and a sulfhydryl-reactive agent. (PubMed id 10824106)9 Rhee H.J....Na D.S. (Eur. J. Biochem. 2000)
    242. Structural determinant of the vesicle aggregation activity of annexin I. (PubMed id 10529257)9 Bitto E. and Cho W. (Biochemistry 1999)
    243. Characterization of the interaction between annexin I and profilin. (PubMed id 8706680)9 Alvarez-Martinez M.T....Sri Widada J. (Eur. J. Biochem. 1996)
    244. Vesicle aggregation by annexin I: role of a secondary membrane binding site. (PubMed id 7654693)9 de la Fuente M. and Parra A.V. (Biochemistry 1995)
    245. Expression of annexin I, II, V, and VI by rat osteoblasts in primary culture: stimulation of annexin I expression by dexamethasone. (PubMed id 8256657)9 Suarez F....Silve C. (J. Bone Miner. Res. 1993)
    246. Immunohistochemical localization of lipocortins in normal and psoriatic human skin. (PubMed id 8379691)9 Ikai K....Kannagi R. (Arch. Dermatol. Res. 1993)
    247. Lipocortin I production by human alveolar macrophages. (PubMed id 1530812)9 Ambrose M.P....Hunninghake G.W. (Am. J. Respir. Cell Mol. Biol. 1992)
    248. Molecular dynamics simulation studies on Ca2+ -induced conformational changes of annexin I. (PubMed id 18283055)9 Shesham R.D....Li Y. (amp 2008)
    249. Annexin 1, glucocorticoids, and the neuroendocrine-immune interface. (PubMed id 17192583)9 Buckingham J.C....Morris J. (Ann. N. Y. Acad. Sci. 2006)
    250. Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. (PubMed id 16720734)9 Solito E....Buckingham J.C. (FASEB J. 2006)
    251. Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1). (PubMed id 15183626)9 Falini B....Pileri S. (Lancet 2004)
    252. Expression of annexin I, II and VII proteins in androgen stimulated and recurrent prostate cancer. (PubMed id 14713853)9 Smitherman A.B....Ornstein D.K. (J. Urol. 2004)
    253. Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses. (PubMed id 12807488)9 Goodridge H.S....Harnett M.M. (Immunology 2003)
    254. Annexin 1 localisation in tissue eosinophils as detected by electron microscopy. (PubMed id 12467520)9 Oliani S.M....Perretti M. (Mediators Inflamm. 2002)
    255. Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis. (PubMed id 10772777)9 Perretti M....Goulding N.J. (Cell Biol. Int. 2000)
    256. Functional analysis of the human annexin I and VI gene promoters. (PubMed id 9620870)9 Donnelly S.R. and Moss S.E. (Biochem. J. 1998)
    257. Diverse effects of different neutrophil organelles on truncation and membrane-binding characteristics of annexin I. (PubMed id 8664322)9 SjAPlin C. and Dahlgren C. (Biochim. Biophys. Acta 1996)
    258. Expression of lipocortins in human bronchial epithelial cells: effects of IL-1beta , TNF-alpha, LPS and dexamethasone. (PubMed id 18475719)9 Verheggen M.M....Versnel M.A. (Mediators Inflamm. 1996)
    259. Localization of annexin I (lipocortin I, p35) mRNA in normal and diseased human skin by in situ hybridization. (PubMed id 8919037)9 Sato-Matsumura K.C....Nagashima K. (Arch. Dermatol. Res. 1996)
    260. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. (PubMed id 8557999)9 Snijders A....Kapsenberg M.L. (J. Immunol. 1996)
    261. Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. (PubMed id 7605994)9 Hayes M.P....Norcross M.A. (Blood 1995)
    262. Involvement of annexin I and annexin II in hepatocyte proliferation: can annexins I and II be markers for proliferative hepatocytes? (PubMed id 7519163)9 Masaki T....Sogawa K. (Hepatology 1994)
    263. Annexin I and involucrin are cross-linked by particulate transglutaminase into the cornified cell envelope of squamous cell carcinoma Y1. (PubMed id 1348694)9 Moore K.G. and Sartorelli A.C. (Exp. Cell Res. 1992)
    264. Cloning and expression of murine IL-12. (PubMed id 1350290)9 Schoenhaut D.S....Gubler U. (J. Immunol. 1992)
    265. Actin-binding proteins involved in the capping of epidermal growth factor receptors in A431 cells. (PubMed id 1832642)9 Kwiatkowska K....Sobota A. (Exp. Cell Res. 1991)
    266. Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo. (PubMed id 20215502)9 Zhang Z....Rigas B. (Cancer Res. 2010)
    267. Effects of FR235222, a novel HDAC inhibitor, in proliferation and apoptosis of human leukaemia cell lines: role of annexin A1. (PubMed id 18295477)9 Petrella A....Parente L. (Eur. J. Cancer 2008)
    268. Zap70 signaling pathway mediates glucocorticoid receptor-dependent transcriptional activation: role in the regulation of annexin 1 expression in T cells. (PubMed id 17785822)9 Ishaq M....Natarajan V. (J. Immunol. 2007)
    269. Correlation between the antiinflammatory protein annexin 1 (lipocortin 1) and serum cortisol in subjects with normal and dysregulated adrenal function. (PubMed id 15509636)9 Mulla A....Buckingham J.C. (J. Clin. Endocrinol. Metab. 2005)
    270. Expression of annexin A1 in normal and chronically inflamed nasal mucosa. (PubMed id 14967753)9 Rodrigo J.P....Herrero A. (amp 2004)
    271. Three isoforms of annexin I are preferentially expressed in normal esophageal epithelia but down-regulated in esophageal squamous cell carcinomas. (PubMed id 12242662)9 Xia S.H....Wang M.R. (Oncogene 2002)
    272. Cell localization of the anti-inflammatory protein annexin 1 during experimental inflammatory response. (PubMed id 11729999)9 Oliani S.M. and Perretti M. (Ital J Anat Embryol 2001)
    273. Quantification of annexin I in subcellular fractions of human neutrophils reveals an exclusive cytosolic localisation. (PubMed id 11589610)9 Movitz C. and Dahlgren C. (Cell Biol. Int. 2001)
    274. A comparison of the energetics of annexin I and annexin V. (PubMed id 10329195)9 Rosengarth A....Gerke V. (J. Mol. Biol. 1999)
    275. Annexins I and II show differences in subcellular localization and differentiation-related changes in human epidermal keratinocytes. (PubMed id 8919042)9 Ma A.S. and Ozers L.J. (Arch. Dermatol. Res. 1996)
    276. Annexin I interactions with human neutrophil specific granules: fusogenicity and coaggregation with plasma membrane vesicles. (PubMed id 8476911)9 Meers P....Tauber A.I. (Biochim. Biophys. Acta 1993)
    277. Arachidonic acid metabolism in cells transfected with sense and anti-sense cDNA to annexin I. (PubMed id 8260938)9 Hayashi J....Riley H.D. (Biochem. Mol. Biol. Int. 1993)
    278. Changes in annexin (lipocortin) content in human amnion and chorion at parturition. (PubMed id 1469069)9 Myatt L....Everson W.V. (J. Cell. Biochem. 1992)
    279. Corticosteroids increase lipocortin I in BAL fluid from normal individuals and patients with lung disease. (PubMed id 2140829)9 Ambrose M.P. and Hunninghake G.W. (J. Appl. Physiol. 1990)
    280. Eicosanoid release is increased by membrane destabilization and CFTR inhibition in Calu-3 cells. (PubMed id 19847291)9 Borot F....Ollero M. (PLoS ONE 2009)
    281. Annexin A1 and the formyl peptide receptor family: neuroendocrine and metabolic aspects. (PubMed id 18845272)9 John C.D....Buckingham J.C. (Curr Opin Pharmacol 2008)
    282. Annexin A1 in the brain--undiscovered roles? (PubMed id 18262660)9 Solito E....Gillies G.E. (Trends Pharmacol. Sci. 2008)
    283. Comprehensive interaction of dicalcin with annexins in frog olfactory and respiratory cilia. (PubMed id 17714509)9 Uebi T....Kawamura S. (FEBS J. 2007)
    284. Partially reversible adsorption of annexin A1 on POPC/POPS bilayers investigated by QCM measurements, SFM, and DMC simulations. (PubMed id 16307464)9 Kastl K....Steinem C. (Chembiochem 2006)
    285. Loss of annexin A1 expression in human breast cancer detected by multiple high-throughput analyses. (PubMed id 15567174)9 Shen D....Gornbein J.A. (Biochem. Biophys. Res. Commun. 2005)
    286. Dexamethasone-induced and estradiol-induced CREB activation and annexin 1 expression in CCRF-CEM lymphoblastic cells: evidence for the involvement of cAMP and p38 MAPK. (PubMed id 14668092)9 Castro-Caldas M....Lopes M.C. (Mediators Inflamm. 2003)
    287. A calcium-driven conformational switch of the N-terminal and core domains of annexin A1. (PubMed id 12595246)9 Rosengarth A. and Luecke H. (J. Mol. Biol. 2003)
    288. Annexin 1 regulates cell proliferation by disruption of cell morphology and inhibition of cyclin D1 expression through sustained activation of the ERK1/2 MAPK signal. (PubMed id 14516791)9 Alldridge L.C. and Bryant C.E. (Exp. Cell Res. 2003)
    289. Folding energetics of ligand binding proteins II. Cooperative binding of Ca2+ to annexin I. (PubMed id 11243791)9 Rosengarth A....Gerke V. (J. Mol. Biol. 2001)
    290. Kidney proximal tubule cells: epithelial cells without EGTA-extractable annexins? (PubMed id 11012089)9 Tribolo S....Massey-Harroche D. (Biochem. Cell Biol. 2000)
    291. Lung type II cell and macrophage annexin I release: differential effects of two glucocorticoids. (PubMed id 9887063)9 Hall S.E....Smith S.F. (Am. J. Physiol. 1999)
    292. NMR analyses of the interactions of human annexin I with ATP, Ca2+, and Mg2+. (PubMed id 9563526)9 Han H.Y....Lee B.J. (FEBS Lett. 1998)
    293. Differential expression of annexin I in human mammary ductal epithelial cells in normal and benign and malignant breast tissues. (PubMed id 9062391)9 Ahn S.H....Nicolson G.L. (amp 1997)
    294. Selective translocation of annexins during intracellular redistribution of Chlamydia trachomatis in HeLa and McCoy cells. (PubMed id 8262618)9 Majeed M....Stendahl O. (Infect. Immun. 1994)
    295. Annexins possess functionally distinguishable Ca2+ and phospholipid binding domains. (PubMed id 8179621)9 Ernst J.D....Chew G. (Biochem. Biophys. Res. Commun. 1994)
    296. Alterations of annexin expression in pathological neuronal and glial reactions. Immunohistochemical localization of annexins I, II (p36 and p11 subunits), IV, and VI in the human hippocampus. (PubMed id 8080046)9 Eberhard D.A....VandenBerg S.R. (Am. J. Pathol. 1994)
    297. Annexin I as a potential inhibitor of insulin receptor protein tyrosine kinase. (PubMed id 8093061)9 Melki V....Chap H. (Biochem. Biophys. Res. Commun. 1994)
    298. Glycosylation of annexin I and annexin II. (PubMed id 1445299)9 Goulet F....Sartorelli A.C. (Biochem. Biophys. Res. Commun. 1992)
    299. Lipocortin I (annexin I) is preferentially localized on the plasma membrane in keratinocytes of psoriatic lesional epidermis as shown by immunofluorescence microscopy. (PubMed id 1836217)9 Kitajima Y....Yaoita H. (J. Invest. Dermatol. 1991)
    300. Organization and synergistic binding of copine I and annexin A1 on supported lipid bilayers observed by atomic force microscopy. (PubMed id 19539605)9 Creutz C.E. and Edwardson J.M. (Biochim. Biophys. Acta 2009)
    301. Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy. (PubMed id 19171478)9 Chuthapisith S....Eremin O. (Eur. J. Cancer 2009)
    302. Involvement of annexin A1 in multidrug resistance of K562/ADR cells identified by the proteomic study. (PubMed id 20001861)9 Zhu F....Cao J. (OMICS 2009)
    303. Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70. (PubMed id 19019087)9 Jana M. and Pahan K. (Immunology 2009)
    304. Formation of irreversibly bound annexin A1 protein domains on POPC/POPS solid supported membranes. (PubMed id 18237543)9 Faiss S....Steinem C. (Biochim. Biophys. Acta 2008)
    305. Insights into S100 target specificity examined by a new interaction between S100A11 and annexin A2. (PubMed id 17144662)9 Rintala-Dempsey A.C....Shaw G.S. (Biochemistry 2006)
    306. Overexpression of annexin 1 in pancreatic cancer and its clinical significance. (PubMed id 15133855)9 Bai X.F....Zhao X.H. (World J. Gastroenterol. 2004)
    307. Changes in gene expression during chemical-induced nephrocarcinogenicity in the Eker rat. (PubMed id 14587099)9 Patel S.K....Lau S.S. (Mol. Carcinog. 2003)
    308. A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. (PubMed id 12824302)9 Solito E....Perretti M. (FASEB J. 2003)
    309. Unmasking the annexin I interaction from the structure of Apo-S100A11. (PubMed id 12842051)9 Dempsey A.C....Shaw G.S. (Structure 2003)
    310. Kinetics and thermodynamics of annexin A1 binding to solid-supported membranes: a QCM study. (PubMed id 12146973)9 Kastl K....Steinem C. (Biochemistry 2002)
    311. Two proteins modulating transendothelial migration of leukocytes recognize novel carboxylated glycans on endothelial cells. (PubMed id 11254728)9 Srikrishna G....Freeze H.H. (J. Immunol. 2001)
    312. Differentially expressed genes in two LNCaP prostate cancer cell lines reflecting changes during prostate cancer progression. (PubMed id 10950117)9 Vaarala M.H....Vihko P. ( a journal of technical methods and pathology 2000)
    313. Histidine phosphorylation of annexin I in airway epithelia. (PubMed id 10956639)9 Muimo R....Mehta A. (J. Biol. Chem. 2000)
    314. Differences in cytokine mRNA profiles between premalignant and malignant lesions of the uterine cervix. (PubMed id 10448305)9 de Gruijl T.D....Scheper R.J. (Eur. J. Cancer 1999)
    315. Ca2+-independent interaction of annexin I with phospholipid monolayers. (PubMed id 9827561)9 Rosengarth A....Gerke V. (FEBS Lett. 1998)
    316. Change in the N-terminal domain conformation of annexin I that correlates with liposome aggregation is impaired by Ser-27 to Glu mutation that mimics phosphorylation. (PubMed id 8620027)9 Porte F....Widada J.S. (Biochim. Biophys. Acta 1996)
    317. Role of the amino-terminal domain in regulating interactions of annexin I with membranes: effects of amino-terminal truncation and mutagenesis of the phosphorylation sites. (PubMed id 8286349)9 Wang W. and Creutz C.E. (Biochemistry 1994)
    318. Mass spectrometric and Edman sequencing of lipocortin I isolated by two-dimensional SDS/PAGE of human melanoma lysates. (PubMed id 8446611)9 Hall S.C....Burlingame A.L. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    319. Structure-function correlations of calcium binding and calcium channel activities based on 3-dimensional models of human annexins I, II, III, V and VII. (PubMed id 8395183)9 Chen J.M....Pincus M.R. (amp 1993)
    320. Proton NMR conformational study of an annexin I fragment: influence of a phospholipidic micellar environment. (PubMed id 8393708)9 Macquaire F....Sanson A. (Biochemistry 1993)
    321. Differential expression of annexins I and II in normal and malignant human mammary epithelial cells. (PubMed id 8387039)9 Schwartz-Albiez R....Wirl G. ( research in biological diversity 1993)
    322. Differentiation of HL-60 cells by phorbol ester is correlated with up-regulation of protein kinase C-alpha. (PubMed id 1444457)9 Edashige K....Utsumi K. (Arch. Biochem. Biophys. 1992)
    323. Identification of a domain that mediates vesicle aggregation reveals functional diversity of annexin repeats. (PubMed id 1707872)9 Ernst J.D....Mok T.L. (J. Biol. Chem. 1991)
    324. Autocrine/paracrine regulation of prolactin release from human decidual cells. (PubMed id 2064175)9 Handwerger S....Markoff E. (Ann. N. Y. Acad. Sci. 1991)
    325. Role of lipocortin I in the glucocorticoid induction of the terminal differentiation of a human squamous carcinoma. (PubMed id 2137129)9 Violette S.M....Sartorelli A.C. (J. Cell. Physiol. 1990)
    326. Differential proteome analysis of human gliomas stratified for loss of heterozygosity on chromosomal arms 1p and 19q. (PubMed id 20167812)9 Grzendowski M....StA1hler K. (Neuro-oncology 2010)
    327. Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan. (PubMed id 20497865)9 Huang T.T....Chen H.R. (J. Formos. Med. Assoc. 2010)
    328. Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. (PubMed id 20107188)9 Dufton N....Flower R.J. (J. Immunol. 2010)
    329. Expression of annexin A1 mRNA in peripheral blood from oral squamous cell carcinoma patients. (PubMed id 19833546)9 Faria P.C....Goulart L.R. (Oral Oncol. 2010)
    330. Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study. (PubMed id 20178593)9 van Erk M.J....van Ommen B. (BMC Med Genomics 2010)
    331. Differential expression proteomics of human colorectal cancer based on a syngeneic cellular model for the progression of adenoma to carcinoma. (PubMed id 19899082)9 Roth U....Hanisch F.G. (Proteomics 2010)
    332. Diagnostic clinical aids in oral cancer. (PubMed id 20371204)9 Seoane LestA^n J. and Diz Dios P. (Oral Oncol. 2010)
    333. Regulation of proliferation, apoptosis and cell cycle in gastrointestinal disorders. (PubMed id 19647486)9 Jackson L.N. and Evers B.M. (Curr Opin Pharmacol 2009)
    334. Annexin I and annexin II N-terminal peptides binding to S100 protein family members: specificity and thermodynamic characterization. (PubMed id 19275165)9 Streicher W.W....Makhatadze G.I. (Biochemistry 2009)
    335. Upregulation of IL-6, IL-8 and CCL2 gene expression after acute inflammation: Correlation to clinical pain. (PubMed id 19233564)9 Wang X.M....Dionne R.A. (Pain 2009)
    336. Plasma membrane-associated annexin A6 reduces Ca2+ entry by stabilizing the cortical actin cytoskeleton. (PubMed id 19386597)9 Monastyrskaya K....Draeger A. (J. Biol. Chem. 2009)
    337. Ustekinumab: lessons learned from targeting interleukin-12/23p40 in immune-mediated diseases. (PubMed id 20074279)9 Elliott M....Szapary P. (Ann. N. Y. Acad. Sci. 2009)
    338. IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages. (PubMed id 19100623)9 Jana M. and Pahan K. (Mol. Immunol. 2009)
    339. A new pathway of staphylococcal pathogenesis: apoptosis-like death induced by Staphopain B in human neutrophils and monocytes. (PubMed id 20375568)9 Smagur J....Potempa J. (J Innate Immun 2009)
    340. Atorvastatin modifies the protein profile of circulating human monocytes after an acute coronary syndrome. (PubMed id 19294693)9 Barderas M.G....Vivanco F. (Proteomics 2009)
    341. Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells. (PubMed id 19637235)9 Liao S.H....Chen G.Q. (Proteomics 2009)
    342. Neurotrophin 3/TrkC-regulated proteins in the human medulloblastoma cell line DAOY. (PubMed id 19156760)9 Gruber-Olipitz M....Lubec G. (Electrophoresis 2009)
    343. Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma. (PubMed id 19737943)9 Schetter A.J....Harris C.C. (Clin. Cancer Res. 2009)
    344. Induction of caspase- and reactive oxygen species-independent phosphatidylserine externalization in primary human neutrophils: role in macrophage recognition and engulfment. (PubMed id 19106181)9 Jitkaew S....Fadeel B. (J. Leukoc. Biol. 2009)
    345. Effects of exogenous annexin-1 on lipopolysaccharide-induced proliferation and reactive oxygen species production partially through modulation of CRAC channels but independent of NF-kappaB pathway. (PubMed id 19685206)9 Xu L.M....Ye D.Y. (Inflamm. Res. 2009)
    346. Multidimensional degradomics identifies systemic autoantigens and intracellular matrix proteins as novel gelatinase B/MMP-9 substrates. (PubMed id 20023747)9 Cauwe B....Opdenakker G. (Integr Biol (Camb) 2009)
    347. Glycoproteomic analysis of human lung adenocarcinomas using glycoarrays and tandem mass spectrometry: differential expression and glycosylation patterns of vimentin and fetuin A isoforms. (PubMed id 19412661)9 Rho J.H....Wang J.Y. (Protein J. 2009)
    348. Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma. (PubMed id 19020748)9 Mohammad H.S....Masaki T. (Int. J. Oncol. 2008)
    349. Annexins sense changes in intracellular pH during hypoxia. (PubMed id 17824845)9 Monastyrskaya K....Draeger A. (Biochem. J. 2008)
    350. Differences in the protein expression in limbal versus central human corneal epithelium--a search for stem cell markers. (PubMed id 18571161)9 Lyngholm M....Ehlers N. (Exp. Eye Res. 2008)
    351. Anandamide inhibits IL-12p40 production by acting on the promoter repressor element GA-12: possible involvement of the COX-2 metabolite prostamide E(2). (PubMed id 17961121)9 Correa F....Guaza C. (Biochem. J. 2008)
    352. Fine-needle aspiration of thyroid nodules: proteomic analysis to identify cancer biomarkers. (PubMed id 18665625)9 Giusti L....Lucacchini A. (J. Proteome Res. 2008)
    353. Fluorescent annexin A1 reveals dynamics of ceramide platforms in living cells. (PubMed id 18694456)9 Babiychuk E.B....Draeger A. (Traffic 2008)
    354. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. (PubMed id 18504258)9 Cao Z....Coffey R.J. (amp 2008)
    355. Protein carbonylation as a novel mechanism in redox signaling. (PubMed id 18079412)9 Wong C.M....Suzuki Y.J. (Circ. Res. 2008)
    356. Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium. (PubMed id 17521776)9 Mhyre T.R....Federoff H.J. (Neurobiol. Aging 2008)
    357. Upregulation of annexin A1 expression by butyrate in human colon adenocarcinoma cells: role of p53, NF-Y, and p38 mitogen-activated protein kinase. (PubMed id 18541673)9 Lecona E....Lizarbe M.A. (Mol. Cell. Biol. 2008)
    358. Proteomic analysis in monocytes of antiphospholipid syndrome patients: deregulation of proteins related to the development of thrombosis. (PubMed id 18759277)9 LA^pez-Pedrera C....Khamashta M. (Arthritis Rheum. 2008)
    359. Identification and transcript analysis of a novel wallaby (Macropus eugenii) basal-like breast cancer cell line. (PubMed id 18179684)9 Sharp J.A....Nicholas K.R. (Mol. Cancer 2008)
    360. Implications of tyrosine phosphoproteomics in cervical carcinogenesis. (PubMed id 18637184)9 Robinson-Bennett B.L....Papaconstantinou J. (J Carcinog 2008)
    361. S100-annexin complexes--structural insights. (PubMed id 18795951)9 Rintala-Dempsey A.C....Shaw G.S. (FEBS J. 2008)
    362. Identification of survival-related genes of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma multiforme. (PubMed id 18260157)9 Ruano Y....MelAcndez B. (Cancer 2008)
    363. Proteome analysis of human androgen-independent prostate cancer cell lines: variable metastatic potentials correlated with vimentin expression. (PubMed id 17566973)9 Wu M....Ma D. (Proteomics 2007)
    364. Proteomics-based identification of proteins secreted in apical surface fluid of squamous metaplastic human tracheobronchial epithelial cells cultured by three-dimensional organotypic air-liquid interface method. (PubMed id 17638865)9 Kim S.W....Koo J.S. (Cancer Res. 2007)
    365. [Screening of differentially expressed proteins from human esophageal cancer and esophageal tissues by two-dimensional difference gel electrophoresis and mass spectrometry]. (PubMed id 17884789)9 Huang Z.Y....Wang W.J. (Nan Fang Yi Ke Da Xue Xue Bao 2007)
    366. Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. (PubMed id 17268060)9 Qiu J....Cheng M. (amp 2007)
    367. DNA microarray data integration by ortholog gene analysis reveals potential molecular mechanisms of estrogen-dependent growth of human uterine fibroids. (PubMed id 17407572)9 Wei T....Onyia J.E. (BMC Womens Health 2007)
    368. Protein and mRNA characterization in human colorectal carcinoma cell lines with different metastatic potentials. (PubMed id 17882654)9 Liang L....Ding Y. (Cancer Invest. 2007)
    369. Proteomic profiling identifies breast tumor metastasis-associated factors in an isogenic model. (PubMed id 17205601)9 Kreunin P....Goodison S. (Proteomics 2007)
    370. Proteomic analysis of human cerebral endothelial cells activated by multiple sclerosis serum and IFNbeta-1b. (PubMed id 17873362)9 Alexander J.S....Smith S.J. (J. Mol. Neurosci. 2007)
    371. Proteomic analysis of human cervical-vaginal fluids. (PubMed id 17539673)9 Tang L.J....Garcia R.C. (J. Proteome Res. 2007)
    372. Differential regulation of interleukin-12 and tumour necrosis factor-alpha by phosphatidylinositol 3-kinase and ERK 1/2 pathways during Mycobacterium tuberculosis infection. (PubMed id 16367946)9 Yang C.S....Jo E.K. (Clin. Exp. Immunol. 2006)
    373. Detection of eight antibodies in cancer patients' sera against proteins derived from the adenocarcinoma A549 cell line using proteomics-based analysis. (PubMed id 16707281)9 Nakanishi T....Shimizu A. (J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2006)
    374. Effect of granulocyte colony-stimulating factor on IL-12 p40 production during chemotherapy for B-cell lineage non-Hodgkin's lymphoma patients. (PubMed id 16930137)9 Toubai T....Imamura M. (Eur. J. Haematol. 2006)
    375. Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer. (PubMed id 17131471)9 Jazii F.R....Salekdeh G.H. (World J. Gastroenterol. 2006)
    376. Antiflammin-2 activates the human formyl-peptide receptor like 1. (PubMed id 17072491)9 Kamal A.M....Perretti M. (ScientificWorldJournal 2006)
    377. Gene expression signatures and biomarkers of noninvasive and invasive breast cancer cells: comprehensive profiles by representational difference analysis, microarrays and proteomics. (PubMed id 16314837)9 Nagaraja G.M....Kandpal R.P. (Oncogene 2006)
    378. Search for the tumor-related proteins of transition cell carcinoma in Taiwan by proteomic analysis. (PubMed id 16400682)9 Sheng K.H....Wu T.F. (Proteomics 2006)
    379. Preliminary proteomic analysis of indomethacin's effect on tumor transplanted with colorectal cancer cell in nude mice. (PubMed id 16584632)9 Wang Y.J....Chen Z.C. (J. Biochem. Mol. Biol. 2006)
    380. Identification of novel phosphoproteins in signaling pathways triggered by latent membrane protein 1 using functional proteomics technology. (PubMed id 16470631)9 Yan G....Cao Y. (Proteomics 2006)
    381. Proteomics for the identification of new prostate cancer biomarkers. (PubMed id 16678055)9 Ornstein D.K. and Tyson D.R. (Urol. Oncol. 2006)
    382. Proteomic analysis of a highly metastatic gastric cancer cell line using two-dimensional differential gel electrophoresis. (PubMed id 16969483)9 Takikawa M....Yamaguchi K. (Oncol. Rep. 2006)
    383. Oncogenic action of phospholipase A2 in prostate cancer. (PubMed id 16182442)9 Dong Q....Sved P. (Cancer Lett. 2006)
    384. [Annexin-1: 2nd messanger of the anti-inflammatory actions of glucocorticoids]. (PubMed id 17334042)9 Castro-Caldas M. (Acta Reumatol Port 2006)
    385. A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide. (PubMed id 16344271)9 Li N....Lu Y. (Carcinogenesis 2006)
    386. A comparative study of protein profiling by proteomic analysis in camptothecin-resistant PC3 and camptothecin-sensitive LNCaP human prostate cancer cells. (PubMed id 17135786)9 Hasegawa N....Nozawa Y. (Urol. Int. 2006)
    387. Annexin A5 inhibits engulfment through internalization of PS-expressing cell membrane patches. (PubMed id 16380116)9 Kenis H....Reutelingsperger C.P. (Exp. Cell Res. 2006)
    388. Proteomic analysis of human whole and parotid salivas following stimulation by different tastes. (PubMed id 16944961)9 Neyraud E....Dransfield E. (J. Proteome Res. 2006)
    389. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)9 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
    390. Proteomic profiling of cholangiocarcinoma cell line treated with pomiferin from Derris malaccensis. (PubMed id 16220529)9 Svasti J....Chen S.T. (Proteomics 2005)
    391. [Differential analysis of tyrosine-phosphorylated proteins in human hepatocellular carcinoma cell lines with different metastasis potentials]. (PubMed id 15975278)9 Zhang L.J....Sun R.X. (Zhonghua Gan Zang Bing Za Zhi 2005)
    392. Cytosolic phospholipase A2-alpha and cyclooxygenase-2 localize to intracellular membranes of EA.hy.926 endothelial cells that are distinct from the endoplasmic reticulum and the Golgi apparatus. (PubMed id 15720401)9 Grewal S....Walker J.H. (FEBS J. 2005)
    393. The conserved core domains of annexins A1, A2, A5, and B12 can be divided into two groups with different Ca2+-dependent membrane-binding properties. (PubMed id 15723527)9 Patel D.R....Haigler H.T. (Biochemistry 2005)
    394. In silico identification of breast cancer genes by combined multiple high throughput analyses. (PubMed id 15647832)9 Shen D....Chang H.R. (Int. J. Mol. Med. 2005)
    395. Identification of differentially expressed proteins in oral squamous cell carcinoma using a global proteomic approach. (PubMed id 15942644)9 Koike H....Tanzawa H. (Int. J. Oncol. 2005)
    396. [Proteome analysis of autoantibodies in sera of patients with cancer]. (PubMed id 15966408)9 Ueda K. (Rinsho Byori 2005)
    397. Gene expression studies provide clues to the pathogenesis of uterine leiomyoma: new evidence and a systematic review. (PubMed id 15705628)9 Arslan A.A....Toniolo P. (Hum. Reprod. 2005)
    398. An overview of the effects of annexin 1 on cells involved in the inflammatory process. (PubMed id 15962097)9 Kamal A.M....Perretti M. (Mem. Inst. Oswaldo Cruz 2005)
    399. Over-expression of gastrin-releasing peptide in human esophageal squamous cell carcinomas. (PubMed id 14764456)9 Fang M.Z....Yang C.S. (Carcinogenesis 2004)
    400. Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray. (PubMed id 14647409)9 Luo A....Liu Z. (Oncogene 2004)
    401. Annexin expression in inflammatory myopathies. (PubMed id 15221885)9 Probst-Cousin S....Heuss D. (amp 2004)
    402. Nucleocytoplasmic lectins. (PubMed id 15238251)9 Wang J.L....Patterson R.J. (Biochim. Biophys. Acta 2004)
    403. Treatment of murine hepatocellular carcinoma using genetically modified cells to express interleukin-12. (PubMed id 15012775)9 Peron J.M....Favre G. (J. Gastroenterol. Hepatol. 2004)
    404. Identification of proteins in activated human neutrophils susceptible to tyrosyl radical attack. A proteomic study using a tyrosylating fluorophore. (PubMed id 15274135)9 Avram D....Wirtz K.W. (Proteomics 2004)
    405. Dominant prostasome immunogens for sperm-agglutinating autoantibodies of infertile men. (PubMed id 15292099)9 Carlsson L....Larsson A. (J. Androl. 2004)
    406. Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entrAce for resoleomics. (PubMed id 15061569)9 Serhan C.N. and Chiang N. (Rheum. Dis. Clin. North Am. 2004)
    407. Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein. (PubMed id 15489234)9 Liu J....Ma X. (J. Biol. Chem. 2004)
    408. Cell surface-expressed phosphatidylserine and annexin A5 open a novel portal of cell entry. (PubMed id 15381697)9 Kenis H....Reutelingsperger C.P. (J. Biol. Chem. 2004)
    409. Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells. (PubMed id 15180965)9 Sheibanie A.F....Ganea D. (FASEB J. 2004)
    410. The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma. (PubMed id 12845669)9 Zhi H....Liu Z. (Int. J. Cancer 2003)
    411. Annexin A1 processing is associated with caspase-dependent apoptosis in BZR cells. (PubMed id 12832039)9 Debret R....Antonicelli F. (FEBS Lett. 2003)
    412. Protein profiling of the human epidermis from the elderly reveals up-regulation of a signature of interferon-gamma-induced polypeptides that includes manganese-superoxide dismutase and the p85beta subunit of phosphatidylinositol 3-kinase. (PubMed id 12644569)9 Gromov P....Celis J.E. (amp 2003)
    413. The annexin 1 receptor(s): is the plot unravelling? (PubMed id 14607080)9 Perretti M. (Trends Pharmacol. Sci. 2003)
    414. Identification of metastasis-associated proteins by proteomic analysis and functional exploration of interleukin-18 in metastasis. (PubMed id 12748951)9 Jiang D....He F. (Proteomics 2003)
    415. An optimized method for the isolation and identification of membrane proteins. (PubMed id 12783457)9 Lehner I....Borlak J. (Electrophoresis 2003)
    416. Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase C, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase. (PubMed id 12639897)9 Solito E....Buckingham J.C. (Endocrinology 2003)
    417. Serological and proteomic evaluation of antibody responses in the identification of tumor antigens in renal cell carcinoma. (PubMed id 12548633)9 Unwin R.D....Banks R.E. (Proteomics 2003)
    418. Modulation of annexin I and cyclooxygenase-2 in smokeless tobacco-induced inflammation and oral cancer. (PubMed id 12870656)9 Vishwanatha J.K....Banerjee A.G. (Mol. Cell. Biochem. 2003)
    419. Annexin II expression is reduced or lost in prostate cancer cells and its re-expression inhibits prostate cancer cell migration. (PubMed id 12629510)9 Liu J.W....Tang D.G. (Oncogene 2003)
    420. Dexamethasone enhances interaction of endogenous annexin 1 with L-selectin and triggers shedding of L-selectin in the monocytic cell line U-937. (PubMed id 12967943)9 de Coupade C....Levine J.D. (Br. J. Pharmacol. 2003)
    421. Phase diagrams: a graphical representation of linkage relations. (PubMed id 12684012)9 RAPsgen J. and Hinz H.J. (J. Mol. Biol. 2003)
    422. Histidine kinases and histidine phosphorylated proteins in mammalian cell biology, signal transduction and cancer. (PubMed id 12536071)9 Steeg P.S....Salerno M. (Cancer Lett. 2003)
    423. Matrix vesicles and calcification. (PubMed id 12744815)9 Anderson H.C. (Curr Rheumatol Rep 2003)
    424. Ethanol-induced augmentation of annexin IV in cultured cells and the enhancement of cytotoxicity by overexpression of annexin IV by ethanol. (PubMed id 12393176)9 Ohkawa H....Saito T. (Biochim. Biophys. Acta 2002)
    425. Regulation of CD154-induced interleukin-12 production in synovial fluid macrophages. (PubMed id 12223112)9 MAPttAPnen M....Lassila O. (Arthritis Res. 2002)
    426. Dysregulation of annexin I protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer. (PubMed id 11801547)9 Kang J.S....Ornstein D.K. (Clin. Cancer Res. 2002)
    427. The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes. (PubMed id 11940489)9 Airoldi I....Pistoia V. (Haematologica 2002)
    428. HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection. (PubMed id 12444143)9 Mirani M....Kino T. (J. Immunol. 2002)
    429. [Analysis of proteins with altered expression in human esophageal squamous cell carcinomas]. (PubMed id 12500389)9 Xia S.H....Wang M.R. (Ai Zheng 2002)
    430. Ethanol-induced augmentation of annexin IV expression in rat C6 glioma and human A549 adenocarcinoma cells. (PubMed id 12198374)9 Sohma H....Saito T. (Alcohol. Clin. Exp. Res. 2002)
    431. DNA chain unwinding and annealing reactions of lipocortin (annexin) I heterotetramer: regulation by Ca(2+) and Mg(2+). (PubMed id 11846390)9 Hirata A. and Hirata F. (Biochem. Biophys. Res. Commun. 2002)
    432. [Significance on expressions of Annexin-I and its correlative gene proteins in endometrial hyperplasia, atypical hyperplasia and endometrial carcinoma]. (PubMed id 11758212)9 Da J....Zhu Y. (Zhonghua Bing Li Xue Za Zhi 2001)
    433. An immune response manifested by the common occurrence of annexins I and II autoantibodies and high circulating levels of IL-6 in lung cancer. (PubMed id 11504947)9 Brichory F.M....Hanash S.M. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    434. Differential effects of annexins I, II, III, and V on cytosolic phospholipase A2 activity: specific interaction model. (PubMed id 11165258)9 Kim S....Na D.S. (FEBS Lett. 2001)
    435. Visualization of annexin I binding to calcium-induced phosphatidylserine domains. (PubMed id 11828493)9 Janshoff A....Steinem C. (Chembiochem 2001)
    436. Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes. (PubMed id 11221876)9 Hippo Y....Aburatani H. (Cancer Res. 2001)
    437. Solution structure and membrane-binding property of the N-terminal tail domain of human annexin I. (PubMed id 11078886)9 Yoon M.K....Lee B.J. (FEBS Lett. 2000)
    438. Lipocortin-1 fails to ameliorate cold-injury brain edema in the rat. (PubMed id 11450032)9 Mima T. and Shigeno T. (Acta Neurochir. Suppl. 2000)
    439. Crystallization and preliminary X-ray analysis of full-length annexin I comprising the core and N-terminal domain. (PubMed id 11053851)9 Rosengarth A. and Luecke H. (Acta Crystallogr. D Biol. Crystallogr. 2000)
    440. S100-annexin complexes: some insights from structural studies. (PubMed id 11067764)9 Lewit-Bentley A....Gerke V. (Cell Biol. Int. 2000)
    441. Endogenous cleavage of annexin I generates a truncated protein with a reduced calcium requirement for binding to neutrophil secretory vesicles and plasma membrane. (PubMed id 11018667)9 Movitz C. and Dahlgren C. (Biochim. Biophys. Acta 2000)
    442. Cleavage of annexin I in human neutrophils is mediated by a membrane-localized metalloprotease. (PubMed id 9889336)9 Movitz C....Dahlgren C. (Biochim. Biophys. Acta 1999)
    443. Detection of annexin I and IV and haptoglobin in bronchoalveolar lavage fluid from calves experimentally inoculated with Pasteurella haemolytica. (PubMed id 10566814)9 Katoh N....Watanabe A. (Am. J. Vet. Res. 1999)
    444. Suppression of interleukin-12 production by human monocytes after preincubation with lipopolysaccharide. (PubMed id 10477697)9 Wittmann M....Werfel T. (Blood 1999)
    445. Impaired production of IL-12 in systemic lupus erythematosus. III: deficient IL-12 p40 gene expression and cross-regulation of IL-12, IL-10 and IFN-gamma gene expression. (PubMed id 10525320)9 Liu T.F....Srivastava G. (Cytokine 1999)
    446. Lipocortin (Annexin) I heterotetramer binds to purine RNA and pyrimidine DNA. (PubMed id 10548514)9 Hirata A. and Hirata F. (Biochem. Biophys. Res. Commun. 1999)
    447. Differential expression of annexins I, II and IV in human tissues: an immunohistochemical study. (PubMed id 9720986)9 Dreier R....Riehemann K. (Histochem. Cell Biol. 1998)
    448. Adenosine 5'-triphosphate--a new regulator of annexin function. A hypothesis. (PubMed id 9918500)9 Bandorowicz-PikuA8a J. and PikuA8a S. (Acta Biochim. Pol. 1998)
    449. Novel pathways for glucocorticoid effects on neutrophils in chronic inflammation. (PubMed id 9831319)9 Goulding N.J....Perretti M. (Inflamm. Res. 1998)
    450. Roles of calcium and annexins in phagocytosis and elimination of an attenuated strain of Mycobacterium tuberculosis in human neutrophils. (PubMed id 9600863)9 Majeed M....Stendahl O. (Microb. Pathog. 1998)
    451. Decreased IL-12 production and Th1 cell development by acetyl salicylic acid-mediated inhibition of NF-kappaB. (PubMed id 9808189)9 Mazzeo D....D'Ambrosio D. (Eur. J. Immunol. 1998)
    452. Lipocortin 1 (annexin 1) in patches associated with the membrane of a lung adenocarcinoma cell line and in the cell cytoplasm. (PubMed id 9570758)9 Traverso V....Buckingham J. (J. Cell. Sci. 1998)
    453. Positive and negative regulation of interleukin-12 gene expression. (PubMed id 9831187)9 Ma X....Trinchieri G. (Eur. Cytokine Netw. 1998)
    454. Lipocortin I gene expression is higher in blood monocytes than in BAL fluid macrophages in patients with pulmonary sarcoidosis. (PubMed id 9572000)9 Mikuniya T....Izumi T. (Sarcoidosis Vasc Diffuse Lung Dis 1998)
    455. Increased expression of annexin I and thioredoxin detected by two-dimensional gel electrophoresis of drug resistant human stomach cancer cells. (PubMed id 9870185)9 Sinha P....Lage H. (J. Biochem. Biophys. Methods 1998)
    456. Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. (PubMed id 9637507)9 Aste-Amezaga M....Trinchieri G. (J. Immunol. 1998)
    457. Elevated levels of annexin I protein in vitro and in vivo in rat and human mammary adenocarcinoma. (PubMed id 9514092)9 Pencil S.D. and Toth M. (amp 1998)
    458. Identification of glyceraldehyde-3-phosphate dehydrogenase as a Ca2+-dependent fusogen in human neutrophil cytosol. (PubMed id 9500520)9 Hessler R.J....Smolen J.E. (J. Leukoc. Biol. 1998)
    459. Hinge-bending motions in annexins: molecular dynamics and essential dynamics of apo-annexin V and of calcium bound annexin V and I. (PubMed id 9862208)9 Cregut D....Chiche L. (Protein Eng. 1998)
    460. Detection of cytokine mRNA in human, articular cartilage from patients with rheumatoid arthritis and osteoarthritis by reverse transcriptase-polymerase chain reaction. (PubMed id 9506880)9 Leistad L....Faxvaag A. (Scand. J. Rheumatol. 1998)
    461. Calcium-dependent neutrophil secretion: characterization and regulation by annexins. (PubMed id 9550422)9 Rosales J.L. and Ernst J.D. (J. Immunol. 1997)
    462. Localization of five annexins in J774 macrophages and on isolated phagosomes. (PubMed id 9191044)9 Diakonova M....Griffiths G. (J. Cell. Sci. 1997)
    463. Structure of human annexin I: comparison of homology modelling and crystallographic experiment. (PubMed id 9479453)9 Musat G.V....Sanson A. (Biochimie 1997)
    464. Presence and comparison of Ca2+ transport activity of annexins I, II, V, and VI in large unilamellar vesicles. (PubMed id 9299392)9 Matsuda R....Horikawa Y. (Biochem. Biophys. Res. Commun. 1997)
    465. Inhibition of human interleukin-12 production by pentoxifylline. (PubMed id 9227317)9 Moller D.R....Karp C.L. (Immunology 1997)
    466. Structural analysis of junctions formed between lipid membranes and several annexins by cryo-electron microscopy. (PubMed id 9299336)9 Lambert O....Brisson A. (J. Mol. Biol. 1997)
    467. Priming with IL-4 and IL-13 during HIV-1 infection restores in vitro IL-12 production by mononuclear cells of HIV-infected patients. (PubMed id 9548515)9 Marshall J.D....Chehimi J. (J. Immunol. 1997)
    468. Participation of annexins in protein phosphorylation. (PubMed id 9230930)9 Rothhut B. (Cell. Mol. Life Sci. 1997)
    469. S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes. (PubMed id 9115270)9 Robinson N.A.... Eckert R.L. (J. Biol. Chem. 1997)
    470. Highly sensitive and stable phosphatidylserine liposome aggregation assay for annexins. (PubMed id 9324954)9 Lee G. and Pollard H.B. (Anal. Biochem. 1997)
    471. Binding to phosphatidyl serine membranes causes a conformational change in the concave face of annexin I. (PubMed id 8994623)9 de la Fuente M. and Ossa C.G. (Biophys. J. 1997)
    472. Genetic instabilities of chromosome 9, 17 and accumulation of p53 overexpression during multistage tumorigesis in head and neck cancer. (PubMed id 9071074)9 Charuruks N....Hittelman W.N. (J Med Assoc Thai 1996)
    473. The high-resolution crystal structure of human annexin III shows subtle differences with annexin V. (PubMed id 8639653)9 Favier-Perron B.... Russo-Marie F. (Biochemistry 1996)
    474. Degradation of antiflammin 2 under acidic conditions. (PubMed id 8818992)9 Ye J.M....Wolfe J.L. (J Pharm Sci 1996)
    475. The structure of recombinant human annexin VI in crystals and membrane-bound. (PubMed id 8709144)9 Benz J.... Voges D. (J. Mol. Biol. 1996)
    476. Annexins II, IV, V and VI relocate in response to rises in intracellular calcium in human foreskin fibroblasts. (PubMed id 8834809)9 Barwise J.L. and Walker J.H. (J. Cell. Sci. 1996)
    477. Distribution of annexin I and II in term human fetal membranes, decidua and placenta. (PubMed id 8730889)9 Sun M....Gibb W. (Placenta 1996)
    478. The exon 3 encoded sequence of the intracellular serine proteinase inhibitor plasminogen activator inhibitor 2 is a protein binding domain. (PubMed id 8900173)9 Jensen P.H....Pepinsky B. (J. Biol. Chem. 1996)
    479. The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein. (PubMed id 8636985)9 Burger A.... Weber K. (J. Mol. Biol. 1996)
    480. A rise in nuclear calcium translocates annexins IV and V to the nuclear envelope. (PubMed id 8774858)9 Raynal P....Pollard H.B. (FEBS Lett. 1996)
    481. Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene with alternatively spliced 5' noncoding exons. (PubMed id 8634333)9 Fey M.F....Tack B.F. (Biochim. Biophys. Acta 1996)
    482. Monkey Clara cell 10 kDa protein (CC10): a characterization of the amino acid sequence with an evolutional comparison with humans, rabbits, rats, and mice. (PubMed id 8810640)9 Hashimoto S....Sueishi K. (Am. J. Respir. Cell Mol. Biol. 1996)
    483. Inhibitory effect of annexin V on protein kinase C activity in mesangial cell lysates. (PubMed id 7588728)9 Rothhut B....Oudinet J.P. (Eur. J. Biochem. 1995)
    484. Potential interaction between annexin VI and a 56-kDa protein kinase in T cells. (PubMed id 7541988)9 Dubois T....Rothhut B. (Biochem. Biophys. Res. Commun. 1995)
    485. Plant annexin form homodimer during Ca(2+)-dependent liposome aggregation. (PubMed id 7627125)9 Hoshino T....Mizutani J. (Biochem. Mol. Biol. Int. 1995)
    486. An intramolecular disulfide bond is essential for annexin I-mediated liposome aggregation. (PubMed id 7663390)9 Liu L. and Zimmerman U.J. (Biochem. Mol. Biol. Int. 1995)
    487. Differential distribution of annexins-I, -II, -IV, and -VI in synovium. (PubMed id 7492225)9 Goulding N.J....Edwards J.C. (Ann. Rheum. Dis. 1995)
    488. Responsiveness of peripheral blood mononuclear cells from normal and atopic donors to microbial superantigens. (PubMed id 7819740)9 KAPnig B....KAPnig W. (Int. Arch. Allergy Immunol. 1995)
    489. Annexins I, II and III are specific choline binding proteins. (PubMed id 7663385)9 Zimmerman U.J....Fisher A.B. (Biochem. Mol. Biol. Int. 1995)
    490. Interleukin-12 production by human polymorphonuclear leukocytes. (PubMed id 7843218)9 Cassatella M.A....Trinchieri G. (Eur. J. Immunol. 1995)
    491. Effect of calcium on phenothiazine inhibition of neutrophil degranulation. (PubMed id 7616103)9 Blackwood R.A. and Hessler R.J. (J. Leukoc. Biol. 1995)
    492. Lipocortin I is not accessible for protein kinase C bound to the cytoplasmic surface of the plasma membrane in streptolysin-O-permeabilized pig granulocytes. (PubMed id 8305505)9 Farkas G....FaragA^ A. (Biochim. Biophys. Acta 1994)
    493. The expression of phospholipase A2 and lipocortins (annexins) I, II and V in human fetal membranes and placenta in association with labour. (PubMed id 7991777)9 Bennett P....Moor G. (Prostaglandins 1994)
    494. Interdependence of phospholipid specificity and calcium binding in annexin I as shown by site-directed mutagenesis. (PubMed id 8155700)9 TravAc G....Liautard J.P. (Biochim. Biophys. Acta 1994)
    495. Homology modelling of annexin I: implicit solvation improves side-chain prediction and combination of evaluation criteria allows recognition of different types of conformational error. (PubMed id 7700865)9 Cregut D....Chiche L. (Protein Eng. 1994)
    496. Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10. (PubMed id 7515686)9 Shirvan A.... Burns A.L. (Biochemistry 1994)
    497. Structure of the human annexin VI gene. (PubMed id 8146179)9 Smith P.D....Moss S.E. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    498. The gene encoding human annexin V has a TATA-less promoter with a high G+C content. (PubMed id 7958998)9 Fernandez M.-P.... Carcedo M.-T. (Gene 1994)
    499. Identification and characterization of alpha-protein kinase C binding proteins in normal and transformed REF52 cells. (PubMed id 8110754)9 Hyatt S.L.... Jaken S. (Biochemistry 1994)
    500. Chromaffin granules release calcium on contact with annexin VI: implications for exocytosis. (PubMed id 8031751)9 Jones P.G....Waisman D.M. (Biochemistry 1994)
    501. High-level expression of human lipocortin I in the fission yeast Schizosaccharomyces pombe using a novel expression vector. (PubMed id 7764687)9 Giga-Hama Y....Kumagai H. (Biotechnology (N.Y.) 1994)
    502. Agonists and antagonists of protein kinase C function, derived from its binding proteins. (PubMed id 8063768)9 Ron D. and Mochly-Rosen D. (J. Biol. Chem. 1994)
    503. Calcium-induced translocation of annexins to subcellular organelles of human neutrophils. (PubMed id 8002935)9 SjAPlin C....Dahlgren C. (Biochem. J. 1994)

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 301 HGNC: 533 AceView: ANXA1 Ensembl:ENSG00000135046 euGenes: HUgn301
    ECgene: ANXA1 H-InvDB: ANXA1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANXA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANXA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANXA1 gene:
    Search GeneIP for patents involving ANXA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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