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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANXA1 Gene

protein-coding GIFtS: 71
GCID: GC09P075766

annexin A1

(Previous symbols: ANX1, LPC1)

Explore 74 diseases affiliated with
ANXA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Annexin A1¹ ²		Annexin-1³
LPC1¹ ² ³ ⁵		Calpactin-2³
ANX1¹ ² ³		Chromobindin-9³
Calpactin II² ³		Annexin-1³
Lipocortin I² ³		Calpactin-2³
Phospholipase A2 Inhibitory Protein² ³		Chromobindin-9³
P35¹		Annexin I³
Annexin I (Lipocortin I)²

External Ids:	HGNC: 533¹	Entrez Gene: 301²	Ensembl: ENSG00000135046⁷	OMIM: 151690⁵	UniProtKB: P04083³

Export aliases for ANXA1 gene to outside databases

Previous GC identifers: GC09P066811 GC09P067623 GC09P069336 GC09P071223 GC09P072996 GC09P074956 GC09P045589

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANXA1:

Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of

approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I

protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since

phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and

leukotrienes, annexin I may have potential anti-inflammatory activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083

Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This

protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Gene Wiki entry for ANXA1 (Annexin A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANXA1 gene promoter:
C/EBPbeta POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 C/EBPalpha AREB6 POU2F1 POU2F1a STAT3 TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ANXA1 promoter sequence

Search SABiosciences Chromatin IP Primers for ANXA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13 Ensembl cytogenetic band: 9q21.13 HGNC cytogenetic band: 9q21.13

ANXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P075766: view genomic region (about GC identifiers)

Start:	75,766,673 bp from pter	End:	75,785,309 bp from pter
Size:	18,637 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083 (See protein sequence)

Recommended Name: Annexin A1

Size: 346 amino acids; 38714 Da

Subunit: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity)

Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity).

Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated

cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar

macrophages (By similarity)

3 PDB 3D structures from and Proteopedia for ANXA1:

1AIN (3D)

1BO9 (3D)

1QLS (3D)

Explore the universe of human proteins at neXtProt for ANXA1: NX_P04083

Post-translational modifications:

Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss

of the inhibitory activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04083

ANXA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000691.1

ENSEMBL proteins:

ENSP00000257497 ENSP00000412489 ENSP00000414013 ENSP00000366109

Reactome Protein details: P04083
Human Recombinant Protein Products:

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	Uscn Proteins for ANXA1

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001533	cornified envelope	IDA	10908733
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IEA	--

ANXA1 for ontologies About GeneDecksing

ANXA1 Antibody Products:

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	ThermoFisher Antibody for ANXA1

Assay Products for ANXA1:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ANXA1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANXA1 for domains About GeneDecksing

4 InterPro domains/families:

IPR001464 Annexin

IPR018252 Annexin_repeat_CS

IPR002388 AnnexinI

IPR018502 Annexin_repeat

Graphical View of Domain Structure for InterPro Entry P04083

ProtoNet protein and cluster: P04083

2 Blocks protein families:

IPB001464 Annexin

IPB002388 Annexin type I signature

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083

Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid

Similarity: Belongs to the annexin family

Similarity: Contains 4 annexin repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083

Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This

protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Genatlas biochemistry entry for ANXA1:

annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of the

organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid feadback

action in the hypothalamo-hypophysial system

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1

Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003697	single-stranded DNA binding	--	--
GO:0003727	single-stranded RNA binding	--	--
GO:0004859	phospholipase inhibitor activity	--	--
GO:0005102	receptor binding	TAS	10882119
GO:0005198	structural molecule activity	IDA	10908733

ANXA1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ANXA1:

Decreased viability

Animal Models:
12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Anxa1):

adipose tissue	cardiovascular system	craniofacial	digestive/alimentary	endocrine/exocrine gland
growth/size	homeostasis/metabolism	immune system	mortality/aging	nervous system
skeleton	tumorigenesis

ANXA1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75			G alpha (i) signalling events	0.44

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

Ca, cAMP and Lipid Signaling

Ca, cAMP and Lipid Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ANXA1

	Selected targets of CREB1
	Selected targets of C/EBPalpha

1 Cell Signaling Technology (CST) Pathway for ANXA1

Ca, cAMP and Lipid Signaling

4 BioSystems Pathways for ANXA1

	Integrated Breast Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Prostaglandin Synthesis and Regulation

5/10 Reactome Pathways for ANXA1 (see all 10)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

ANXA1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ANXA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/309 Interacting proteins for ANXA1 (P04083^{1, 2, 3} ENSP00000257497⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 309)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APBB1	O00213²^,³, ENSP00000299402⁴	MINT-8247707 I2D: score=2 STRING: ENSP00000299402
C14orf1	Q9UKR5²^,³	MINT-8247720 I2D: score=2
CCT7	Q99832²^,³	MINT-8247753 I2D: score=2
COPS6	Q7L5N1²^,³	MINT-8247764 I2D: score=2
CSAD	Q9Y600²^,³	MINT-8247775 I2D: score=2

About this table

Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001776	leukocyte homeostasis	--	--
GO:0001780	neutrophil homeostasis	IMP	--
GO:0002674	negative regulation of acute inflammatory response	IEA	--
GO:0006928	cellular component movement	TAS	10882119
GO:0006954	inflammatory response	TAS	10882119

ANXA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ANXA1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ANXA1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Ac9-25	Annexin I N-terminal peptide. Acts as a FPR1 ligand	[284040-76-2]
Ac2-26	Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation	[151988-33-9]
Ac2-12	Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation	[256447-08-2]

1 HMDB Compound for ANXA1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

3 DrugBank Compounds for ANXA1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Hydrocortisone	11beta-Hydroxycortisone (see all 16)	50-23-7	target	agonist	1712816 17139284 11142771 17016423 8060156
Dexamethasone	Desametasone (see all 9)	50-02-2	target	agonist	17644190 17076770 17158208 16883066
Amcinonide	--	51022-69-6	target	agonist	17139284 17016423 7981624

10/56 Novoseek chemical compound relationships for ANXA1 gene (see all 56) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hdmnkvldl	84.9	2	8818992 (1), 1793057 (1)
phosphatidylserine	62.1	29	8179621 (3), 7627125 (1), 12744815 (1), 15381697 (1) (see all 16)
phospholipid	59.7	33	8379935 (7), 2138536 (1), 1310621 (1), 8485141 (1) (see all 20)
calcium	55	126	11142771 (6), 9299392 (5), 18283055 (4), 1469069 (3) (see all 58)
arachidonic acid	49.2	16	2064175 (2), 8260938 (2), 2137129 (2), 12845669 (1) (see all 10)
dexamethasone	45.3	54	8256657 (6), 12236584 (5), 17644190 (4), 14668092 (3) (see all 17)
glyceraldehyde 3-phosphate	44.7	7	16220529 (1), 17268060 (1), 15274135 (1), 19899082 (1) (see all 7)
geneticin	32.2	1	7764687 (1)
phosphatidylcholine	30.4	17	16307464 (2), 12845669 (1), 7654693 (1), 1387325 (1) (see all 5)
p-opc	30	7	16307464 (3), 18237543 (2)

Search CenterWatch for drugs/clinical trials and news about ANXA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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About This Section

REFSEQ mRNAs for ANXA1 gene:

NM_000700.1

Unigene Cluster for ANXA1:

Annexin A1

Hs.494173 [show with all ESTs]

Unigene Representative Sequence: AK074480

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000257497(uc004ajf.1) ENST00000456643 ENST00000468639 ENST00000415424

ENST00000376911(uc004ajg.1) ENST00000495713 ENST00000489109 ENST00000491192

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Additional cDNA sequence:

AB451274.1 AB451401.1 AK023330.1 AK074480.1 AK296808.1 AK311684.1 BC001275.1 BC018683.1

BC034157.1 BC035993.1 BT019896.1 BT019916.1 BT019917.1 CR407684.1 X05908.1

24/49 DOTS entries (see all 49):

DT.95080391 DT.100890399 DT.95202652 DT.100765659 DT.100890413 DT.100890422 DT.100890394 DT.100890395

DT.121161786 DT.100890415 DT.95340497 DT.95223581 DT.92045136 DT.92466092 DT.100040129 DT.100890410

DT.100890409 DT.91793108 DT.91703452 DT.91949347 DT.121161854 DT.100890404 DT.92466082 DT.92466099

24/1569 AceView cDNA sequences (see all 1569):

BQ434247 CB132717 CB136230 CB110563 BM987259 BQ775882 AL702872 BG760604

CB134061 CA418081 BE885625 BM762806 BP368115 BU615234 BM970156 BU182629

CB161300 CB155823 CA441775 AI962890 AK074480 AU138337 BQ776007 BM981135

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15a	·	15b
SP1:					-		-		-		-		-						-				-						-										-						-
SP2:																			-				-						-										-						-
SP3:					-				-		-		-						-				-						-										-
SP4:																													-										-
SP5:							-		-		-		-						-				-						-

ECgene alternative splicing isoforms for ANXA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANXA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAAGATGT

About this image

ANXA1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epicardium

Kidney

Mesenchymal Condensate Cells

Bone, Cartilage

Adipose

Visceral White Adipose

Adipose

Brain

Medulla Oblongata

Brain

Kidney

Renal Collecting Duct System

Kidney

Lung

Trachea

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

CyT49 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Dorsal forebrain-like neurons (Generation of midbra...)

Brain

N2/LSB induced-cells (Generation of midbra...)

Syncytiotrophoblast-like cells (Generation of syncyt...)

See ANXA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANXA1

SOURCE GeneReport for Unigene cluster: Hs.494173

SABiosciences Expression via Pathway-Focused PCR Array including ANXA1:

Apoptosis 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANXA1 gene from 26 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	ANXA1¹	annexin A1	99.42(n) 99.71(a)		472953 NM_001098567.1 NP_001092037.1
mouse (Mus musculus)	Mammalia	Anxa1^{1 , 5}	annexin A1^{1, 5}	86.61(n)¹ 87.57(a)¹		19 (13.83 cM)⁵ 16952¹ NM_010730.2¹ NP_034860.2¹ 20373428⁵
rat (Rattus norvegicus)	Mammalia	Anxa1¹	annexin A1	86.13(n) 89.02(a)		25380 NM_012904.1 NP_037036.1
cow (Bos taurus)	Mammalia	ANXA1¹	annexin A1	88.57(n) 90.99(a)		327662 NM_175784.3 NP_786978.2
dog (Canis familiaris)	Mammalia	ANXA1¹	annexin A1	89.53(n) 91.86(a)		476322 XM_533524.3 XP_533524.2
oppossum (Monodelphis domestica)	Mammalia	ANXA1⁶	Annexin	86(a)	1 ↔ 1	6(92391531-92419662)
platypus (Ornithorhynchus anatinus)	Mammalia	-- ANXA1⁶	Annexin	81(a)	possible ortholog 1 ↔ 1	X1(28479546-28482517) Ultra200(1144827-1158870)
chicken (Gallus gallus)	Aves	ANXA1¹	annexin A1	75.07(n) 78.59(a)		404271 NM_206906.1 NP_996789.1
lizard (Anolis carolinensis)	Reptilia	ANXA1⁶	--	76(a)	1 ↔ 1	2(47805415-47820443)
African clawed frog (Xenopus laevis)	Amphibia	anxa1-prov²	annexin A1	77.96(n)		BC053786.1
tropical clawed frog (Xenopus tropicalis)	Amphibia	MGC76270²	hypothetical protein MGC76270	74.61(n)		BC064261.1
zebrafish (Danio rerio)	Actinopterygii	anxa1a²	annexin A1a	73.36(n)		334724 AY178793.1
rainbow trout (Oncorhynchus mykiss)	Actinopterygii	Omy.8605²	Oncorhynchus mykiss transcribed sequence with weak more	75.28(n)		CA363738.1
sea squirt (Ciona savignyi)	Ascidiacea	-- --	--	43(a) 36(a)	many ↔ many many ↔ many	reftig_143(712816-713626) reftig_143(782723-796619)
sea urchin (Strongylocentrotus purpuratus)	Echinoidea	-- -- (see all 9)	--	37(a) 34(a) (see all 9)	many ↔ many many ↔ many (see all 9)	scaffold_48114(2968-5789) scaffold_1665(36572-37647)
fruit fly (Drosophila melanogaster)	Insecta	AnnIX³	actin binding	45(a)		93B10 --
honey bee (Apis mellifera)	Insecta	-- -- (see all 4)	--	45(a) 43(a) (see all 4)	possible ortholog possible ortholog (see all 4)	GroupUn.2174(3-438) GroupUn.693(6676-9679)
worm (Caenorhabditis elegans)	Secernentea	nex-2³	Annexin	42(a) (best of 3)		III(10397630-10399688) --
schistosome parasite (Schistosoma mansoni)	Trematoda	Smp_045560⁶ Smp_074150⁶ (see all 11)	Annexin, putative (see all 11)	38(a) 30(a) (see all 11)	possible ortholog possible ortholog (see all 11)	Smp_scaff000115(209235-225774) Smp_scaff000255(59273-105127)
common water flea (Daphnia pulex)	Crustacea	-- -- (see all 14)	--	40(a) 39(a) (see all 14)	possible ortholog possible ortholog (see all 14)	scaffold_83(166431-168383) scaffold_18(945715-947736)
Trichoplax (Trichoplax adhaerens)	Tricoplacia	--	--	35(a)	possible ortholog	scaffold_2(6086650-6089868)
sea anemone (Nematostella vectensis)	Anthozoa	--	--	39(a)	possible ortholog	scaffold_42(832369-837577)
amoeba (Dictyostelium discoideum)	Dictyostelia	NXNA⁶ NXNB⁶	Annexin I	23(a) 17(a)	many ↔ many many ↔ many	1(2864584-2866468) 4(1793617-1795080)
Chromalveolata (Phytophthora infestans)	Oomycota	PITG_11329⁶ PITG_22658⁶ (see all 12)	Annexin (Annexin) Family (see all 12)	6(a) 29(a) (see all 12)	many ↔ many many ↔ many (see all 12)	supercont1.23(504923-508747) supercont1.4892(104-697)
thale cress (Arabidopsis thaliana)	eudicotyledons	ANNAT2⁶ ANNAT5⁶ (see all 8)	annexin D5 (see all 8)	33(a) 32(a) (see all 8)	many ↔ many many ↔ many (see all 8)	5(25973815-25975726) 1(25519442-25520774)
rice (Oryza sativa)	Liliopsida	-- -- (see all 9)	annexin, putative, expressed (see all 9)	36(a) 32(a) (see all 9)	many ↔ many many ↔ many (see all 9)	9(13705487-13710510) 8(20456985-20458908)

Species with no ortholog for ANXA1

ENSEMBL Gene Tree for ANXA1 (if available)
TreeFam Gene Tree for ANXA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANXA1 gene

ANXA3² ANXA6² ANXA5² ANXA9² ANXA2² ANXA7² ANXA8² ANXA11²

ANXA8L2² ANXA10² ANXA8L1² ANXA4² ANXA13²

15 SIMAP similar genes for ANXA1 using alignment to 6 protein entries: ANXA1_HUMAN (see all proteins):

ANXA2 ANXA2P2 DKFZp686H02120 ANXA13 ANXA7 ANXA8

ANXA11 ANXA3 ANXA4 ANXA5 ANXA8L2 ANXA6

ANXA8L1 ANXA9 ANXA10

ANXA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112765295^1,2	C,F,	--	75764783(+)	`TAGTGG/ACTTTC`	1	--	us2k¹		1		NA	120
rs2310312^1,2	C,F,O,A,H,	--	75764998(+)	`CAAAGC/AAAAAT`	1	--	us2k¹		24		NA NS EA WA	2694
rs139090859^1,2		--	75765039(+)	`TTTTAC/TAAAAA`	1	--	us2k¹		0	--	--	--	--
rs142395928^1,2		--	75765093(+)	`AGGAAA/TGTTCC`	1	--	us2k¹		0	--	--	--	--
rs3758355^1,2	C,H,	--	75765100(+)	`TTCCAA/GTAGTT`	1	--	us2k¹		5		EA NS	1898
rs192915422^1,2		--	75765212(+)	`TATTAA/GAAAGT`	1	--	us2k¹		0	--	--	--	--
rs78590593^1,2	C,	--	75765229(+)	`ACATCT/CGTCAA`	1	--	us2k¹		3		CSA WA	121
rs185181036^1,2		--	75765234(+)	`TGTCAA/GGATCA`	1	--	us2k¹		0	--	--	--	--
rs33942988^1,2	C,	--	75765264(+)	`ACTTA-/ACTTGT`	1	--	us2k¹		0	--	--	--	--
rs117038162^1,2	F,	--	75765351(+)	`GATTAG/CATGAT`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for ANXA1 (75766673 - 75785309 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ANXA1
1 CNV: 52859

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANXA1 for disorders           About GeneDecksing

OMIM gene information: 151690    OMIM disorders: --

20/74 diseases for ANXA1 (see all 74):    About MalaCards

b-cell non-hodgkin lymphoma non-hodgkin lymphoma squamous cell carcinoma uterine fibroid

brain edema hodgkin's lymphoma idiopathic pulmonary fibrosis laryngeal squamous cell carcinoma

hairy cell leukemia oral squamous cell carcinoma esophageal squamous cell carcinoma cystic fibrosis

pulmonary fibrosis inflammatory bowel disease sarcoidosis transitional cell carcinoma

psoriatic arthritis rheumatoid arthritis pulmonary sarcoidosis muscular dystrophy

1 disease from the University of Copenhagen DISEASES database for ANXA1:

Carcinoma

10/52 Novoseek disease relationships for ANXA1 gene (see all 52) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell	41.2	25	15447985 (3), 12242662 (2), 18297688 (2), 12679902 (2) (see all 17)
adenocarcinoma lung	38.7	5	17351649 (2), 17974280 (1)
inflammation	32.3	33	9796991 (3), 15962097 (3), 19104500 (2), 9831319 (1) (see all 21)
premalignant	27	6	10448305 (1), 19351789 (1), 19101730 (1), 14695321 (1)
tumors	24.8	58	16270603 (4), 19173988 (3), 17340616 (3), 18652761 (3) (see all 29)
prostatic intraepithelial neoplasia	23.9	4	16324197 (2), 11801547 (1)
colon adenocarcinoma	23.9	6	15526283 (3), 18541673 (2)
oral cancer	21.1	6	18297688 (2), 20371204 (1), 12870656 (1)
cancer	16.7	34	18663355 (4), 20215502 (2), 16324197 (2), 20371204 (1) (see all 15)
metastasis	16.6	22	18535914 (3), 20353277 (3), 18776816 (3), 18223218 (2) (see all 11)

Genetic Association Database (GAD): ANXA1
Human Genome Epidemiology (HuGE) Navigator: ANXA1 (6 documents)

Export disorders for ANXA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANXA1 gene, integrated from 9 sources (see all 516):
(articles sorted by number of sources associating them with ANXA1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PubMed id 2936963)^{1, 2, 3} Wallner B.P.... Pepinsky R.B. (1986)
Crystal structure of human annexin I at 2.5-A resolution. (PubMed id 8453382)^{1, 2, 9} Weng X.... Huber R. (1993)
Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PubMed id 16883066)^{1, 7, 9} Morand E.F....Yang Y.H. (2006)
Phosphorylation of annexin I by TRPM7 channel-kinase. (PubMed id 15485879)^{1, 2} Dorovkov M.V. and Ryazanov A.G. (2004)
[Absence of evidence for the association of single nucleotide polymorphisms in Annexin A1 gene with type 2 diabetes in Chinese] (PubMed id 15476183)^{1, 4} Dong Y....Luo M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of the annexin I gene and evaluation of its role in type 2 diabetes. (PubMed id 11574426)^{1, 4} Lindgren C.M....Groop L.C. (2001)
NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit. (PubMed id 9915835)^{1, 2} Gao J.... Yan H. (1999)
Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. (PubMed id 8425544)^{1, 2} Arcone R.... Ciliberto G. (1993)
Correlation of gene and protein structure of rat and human lipocortin I. (PubMed id 1832554)^{1, 2} Kovacic R.T.... Wallner B.P. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 301	HGNC: 533	AceView: ANXA1	Ensembl:ENSG00000135046	euGenes: HUgn301
ECgene: ANXA1	H-InvDB: ANXA1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANXA1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ANXA1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ANXA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ANXA1 gene:
Search GeneIP for patents involving ANXA1

GeneCards and IP:
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