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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANXA1 Gene

protein-coding GIFtS: 71
GCID: GC09P075766

annexin A1

(Previous symbols: ANX1, LPC1)

Explore 74 diseases affiliated with
ANXA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Annexin A1¹ ²		Annexin-1³
LPC1¹ ² ³ ⁵		Calpactin-2³
ANX1¹ ² ³		Chromobindin-9³
Calpactin II² ³		Annexin-1³
Lipocortin I² ³		Calpactin-2³
Phospholipase A2 Inhibitory Protein² ³		Chromobindin-9³
P35¹		Annexin I³
Annexin I (Lipocortin I)²

External Ids:	HGNC: 533¹	Entrez Gene: 301²	Ensembl: ENSG00000135046⁷	OMIM: 151690⁵	UniProtKB: P04083³

Export aliases for ANXA1 gene to outside databases

Previous GC identifers: GC09P066811 GC09P067623 GC09P069336 GC09P071223 GC09P072996 GC09P074956 GC09P045589

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANXA1:

Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of

approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I

protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since

phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and

leukotrienes, annexin I may have potential anti-inflammatory activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083

Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This

protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Gene Wiki entry for ANXA1 (Annexin A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANXA1 gene promoter:
C/EBPbeta POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 C/EBPalpha AREB6 POU2F1 POU2F1a STAT3 TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ANXA1 promoter sequence

Search SABiosciences Chromatin IP Primers for ANXA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13 Ensembl cytogenetic band: 9q21.13 HGNC cytogenetic band: 9q21.13

ANXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P075766: view genomic region (about GC identifiers)

Start:	75,766,673 bp from pter	End:	75,785,309 bp from pter
Size:	18,637 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083 (See protein sequence)

Recommended Name: Annexin A1

Size: 346 amino acids; 38714 Da

Subunit: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity)

Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity).

Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated

cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar

macrophages (By similarity)

3 PDB 3D structures from and Proteopedia for ANXA1:

1AIN (3D)

1BO9 (3D)

1QLS (3D)

Explore the universe of human proteins at neXtProt for ANXA1: NX_P04083

Post-translational modifications:

Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss

of the inhibitory activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04083

ANXA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000691.1

ENSEMBL proteins:

ENSP00000257497 ENSP00000412489 ENSP00000414013 ENSP00000366109

Reactome Protein details: P04083
Human Recombinant Protein Products for ANXA1:

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	Novus Biologicals ANXA1 Proteins Novus Biologicals ANXA1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for ANXA1
	Uscn Proteins for ANXA1

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001533	cornified envelope	IDA	10908733
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IEA	--

ANXA1 for ontologies About GeneDecksing

ANXA1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ANXA1
	R&D Systems Antibodies for ANXA1 (Annexin A1)
	Cell Signaling Technology (CST) Antibodies for ANXA1
	OriGene Antibodies (see all 3): ANXA1 OriGene Custom Antibody Services for ANXA1
	GenScript Custom Superior Antibodies Services for ANXA1
	Novus Biologicals ANXA1 Antibodies
	Abcam antibodies for ANXA1
	Uscn Antibodies for ANXA1
	ThermoFisher Antibody for ANXA1

Assay Products for ANXA1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ANXA1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ANXA1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANXA1 for domains About GeneDecksing

4 InterPro domains/families:

IPR001464 Annexin

IPR018252 Annexin_repeat_CS

IPR002388 AnnexinI

IPR018502 Annexin_repeat

Graphical View of Domain Structure for InterPro Entry P04083

ProtoNet protein and cluster: P04083

2 Blocks protein families:

IPB001464 Annexin

IPB002388 Annexin type I signature

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083

Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid

Similarity: Belongs to the annexin family

Similarity: Contains 4 annexin repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ANXA1_HUMAN, P04083

Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This

protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Genatlas biochemistry entry for ANXA1:

annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of the

organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid feadback

action in the hypothalamo-hypophysial system

Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003697	single-stranded DNA binding	--	--
GO:0003727	single-stranded RNA binding	--	--
GO:0004859	phospholipase inhibitor activity	--	--
GO:0005102	receptor binding	TAS	10882119
GO:0005198	structural molecule activity	IDA	10908733

ANXA1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ANXA1:

Decreased viability

12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Anxa1):

adipose tissue	cardiovascular system	craniofacial	digestive/alimentary	endocrine/exocrine gland
growth/size	homeostasis/metabolism	immune system	mortality/aging	nervous system
skeleton	tumorigenesis

ANXA1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ANXA1

miRNA Products:		miRTarBase miRNAs that target ANXA1: hsa-mir-196a (MIRT000709)

		OriGene 3'-UTR Clone: ANXA1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANXA1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ANXA1
		SwitchGear 3'UTR luciferase reporter plasmid: ANXA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANXA1 (see all 7) OriGene shRNA RFP: ANXA1 OriGene siRNA: ANXA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANXA1
		Sirion Biotech Custom design and validation of potent shRNA sequences against ANXA1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ANXA1
			Sirion Biotech Customized adenovirus for overexpression of ANXA1 Sirion Biotech Customized adenovirus for potent knockdown of ANXA1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANXA1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANXA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ANXA1 (NM_000700)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ANXA1
		Search LifeMap BioReagents cell lines for ANXA1
		Sirion Biotech Customized stable knockdown cell line services for ANXA1 Sirion Biotech Customized inducible knockdown cell line services for ANXA1 Sirion Biotech Customized stable overexpressing cell line services for ANXA1 Sirion Biotech Customized inducible overexpressing cell line services for ANXA1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75			G alpha (i) signalling events	0.44

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

Ca, cAMP and Lipid Signaling

Ca, cAMP and Lipid Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ANXA1

	Selected targets of CREB1
	Selected targets of C/EBPalpha

1 Cell Signaling Technology (CST) Pathway for ANXA1

Ca, cAMP and Lipid Signaling

4 BioSystems Pathways for ANXA1

	Integrated Breast Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Prostaglandin Synthesis and Regulation

5/10 Reactome Pathways for ANXA1 (see all 10)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

ANXA1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ANXA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

258/309 Interacting proteins for ANXA1 (P04083^{1, 2, 3} ENSP00000257497⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 309) (see top 5)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APBB1	O00213²^,³, ENSP00000299402⁴	MINT-8247707 I2D: score=2 STRING: ENSP00000299402
C14orf1	Q9UKR5²^,³	MINT-8247720 I2D: score=2
CCT7	Q99832²^,³	MINT-8247753 I2D: score=2
COPS6	Q7L5N1²^,³	MINT-8247764 I2D: score=2
CSAD	Q9Y600²^,³	MINT-8247775 I2D: score=2
FAF1	Q9UNN5²^,³	MINT-8247786 I2D: score=2
GAPDH	P04406²^,³	MINT-8247797 I2D: score=2
KLHL23	Q8NBE8²^,³	MINT-8247808 I2D: score=2
LRIF1	Q5T3J3²^,³	MINT-8247731 I2D: score=2
MLL4	Q9UMN6²^,³	MINT-8247832 I2D: score=2
OTUB1	Q96FW1²^,³	MINT-8247844 I2D: score=2
RPA1	P27694²^,³	MINT-8247855 I2D: score=2
UBE2D1	P51668²^,³	MINT-8247866 I2D: score=2
UNC119	Q13432²^,³	MINT-8247877 I2D: score=2
XRCC6	P12956²^,³	MINT-8247888 I2D: score=2
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-51101 MINT-51102 I2D: score=4 STRING: ENSP00000275493
SLX1A	Q9BQ83³, ENSP00000251303⁴	I2D: score=2 STRING: ENSP00000251303
IKBKG	Q9Y6K9¹^,³, ENSP00000358622⁴	EBI-354007,EBI-356130 I2D: score=1 STRING: ENSP00000358622
RIPK1	Q13546¹^,³, ENSP00000259808⁴	EBI-354007,EBI-358507 I2D: score=1 STRING: ENSP00000259808
SLX1B	Q9BQ83³, ENSP00000328940⁴	I2D: score=2 STRING: ENSP00000328940
C1orf123	Q9NWV4²^,³, ENSP00000294360⁴	MINT-8247742 I2D: score=2 STRING: ENSP00000294360
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-3297886 I2D: score=1 STRING: ENSP00000309503
DYSF	O75923³, ENSP00000386881⁴	I2D: score=3 STRING: ENSP00000386881
ATG4B	Q9Y4P1³, ENSP00000384259⁴	I2D: score=2 STRING: ENSP00000384259
DLG3	Q92796³, ENSP00000363480⁴	I2D: score=2 STRING: ENSP00000363480
PPM1B	O75688³, ENSP00000282412⁴	I2D: score=2 STRING: ENSP00000282412
SQSTM1	Q13501³, ENSP00000374455⁴	I2D: score=2 STRING: ENSP00000374455
ACTB	P60709³, ENSP00000349960⁴	I2D: score=1 STRING: ENSP00000349960
FPR1	P21462³, ENSP00000302707⁴	I2D: score=1 STRING: ENSP00000302707
UBE2I	P63279³, ENSP00000324897⁴	I2D: score=1 STRING: ENSP00000324897
UBE3A	Q05086³, ENSP00000381045⁴	I2D: score=1 STRING: ENSP00000381045
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
S100A11	P31949³, ENSP00000271638⁴	I2D: score=3 STRING: ENSP00000271638
USP25	Q9UHP3³, ENSP00000285679⁴	I2D: score=2 STRING: ENSP00000285679
USPL1	Q5W0Q7³, ENSP00000255304⁴	I2D: score=2 STRING: ENSP00000255304
KRT8	P05787³, ENSP00000293308⁴	I2D: score=3 STRING: ENSP00000293308
PRKCI	P41743³, ENSP00000295797⁴	I2D: score=1 STRING: ENSP00000295797
SRC	P12931³, ENSP00000350941⁴	I2D: score=2 STRING: ENSP00000350941
SUMO1	P63165³, ENSP00000376076⁴	I2D: score=1 STRING: ENSP00000376076
TGM2	P21980³, ENSP00000355330⁴	I2D: score=2 STRING: ENSP00000355330
TRPM7	Q96QT4³, ENSP00000320239⁴	I2D: score=1 STRING: ENSP00000320239
RELA	Q04206³, ENSP00000384273⁴	I2D: score=1 STRING: ENSP00000384273
SUMO2	P61956³, ENSP00000405965⁴	I2D: score=1 STRING: ENSP00000405965
UCHL5	Q9Y5K5³, ENSP00000356425⁴	I2D: score=1 STRING: ENSP00000356425
NFKBIA	P25963³, ENSP00000216797⁴	I2D: score=1 STRING: ENSP00000216797
YWHAQ	P27348³, ENSP00000238081⁴	I2D: score=1 STRING: ENSP00000238081
CD4	P01730³, ENSP00000011653⁴	I2D: score=1 STRING: ENSP00000011653
APC	P25054³	I2D: score=1
C12orf44	Q9BSB4³	I2D: score=1
CSF1	P09603³	I2D: score=1
GABARAPL1	Q9H0R8³	I2D: score=1
NSMAF	Q92636³	I2D: score=1
PDPK1	O15530³	I2D: score=1
PLA2G4A	P47712³	I2D: score=1
SLC2A4	P14672³	I2D: score=1
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADCY9	ENSP00000294016⁴	STRING: ENSP00000294016
APP	ENSP00000284981⁴	STRING: ENSP00000284981
BDKRB2	ENSP00000307713⁴	STRING: ENSP00000307713
C3	ENSP00000245907⁴	STRING: ENSP00000245907
C5	ENSP00000223642⁴	STRING: ENSP00000223642
C5AR1	ENSP00000347197⁴	STRING: ENSP00000347197
CCK	ENSP00000335657⁴	STRING: ENSP00000335657
CCL20	ENSP00000351671⁴	STRING: ENSP00000351671
CCL21	ENSP00000259607⁴	STRING: ENSP00000259607
CCL5	ENSP00000293272⁴	STRING: ENSP00000293272
CCR1	ENSP00000296140⁴	STRING: ENSP00000296140
CCR5	ENSP00000292303⁴	STRING: ENSP00000292303
CCR7	ENSP00000246657⁴	STRING: ENSP00000246657
CXCL1	ENSP00000379110⁴	STRING: ENSP00000379110
CXCL13	ENSP00000286758⁴	STRING: ENSP00000286758
CXCL3	ENSP00000296026⁴	STRING: ENSP00000296026
CXCL5	ENSP00000296027⁴	STRING: ENSP00000296027
CXCL6	ENSP00000226317⁴	STRING: ENSP00000226317
CXCR2	ENSP00000319635⁴	STRING: ENSP00000319635
CYSLTR2	ENSP00000282018⁴	STRING: ENSP00000282018
EDN1	ENSP00000368683⁴	STRING: ENSP00000368683
EDNRA	ENSP00000315011⁴	STRING: ENSP00000315011
EDNRB	ENSP00000335311⁴	STRING: ENSP00000335311
F2R	ENSP00000321326⁴	STRING: ENSP00000321326
F2RL1	ENSP00000296677⁴	STRING: ENSP00000296677
FPR2	ENSP00000340191⁴	STRING: ENSP00000340191
FPR3	ENSP00000341821⁴	STRING: ENSP00000341821
GAL	ENSP00000265643⁴	STRING: ENSP00000265643
GCG	ENSP00000387662⁴	STRING: ENSP00000387662
GCGR	ENSP00000383558⁴	STRING: ENSP00000383558
GNA15	ENSP00000262958⁴	STRING: ENSP00000262958
GNAI2	ENSP00000312999⁴	STRING: ENSP00000312999
GNRH1	ENSP00000276414⁴	STRING: ENSP00000276414
GNRHR	ENSP00000226413⁴	STRING: ENSP00000226413
GPR18	ENSP00000343428⁴	STRING: ENSP00000343428
GRP	ENSP00000256857⁴	STRING: ENSP00000256857
HTR2B	ENSP00000258400⁴	STRING: ENSP00000258400
KNG1	ENSP00000265023⁴	STRING: ENSP00000265023
LTB4R	ENSP00000307445⁴	STRING: ENSP00000307445
NMU	ENSP00000264218⁴	STRING: ENSP00000264218
NPY	ENSP00000242152⁴	STRING: ENSP00000242152
PIK3CA	ENSP00000263967⁴	STRING: ENSP00000263967
PLCB2	ENSP00000260402⁴	STRING: ENSP00000260402
POMC	ENSP00000264708⁴	STRING: ENSP00000264708
PTAFR	ENSP00000301974⁴	STRING: ENSP00000301974
PTGDR2	ENSP00000332812⁴	STRING: ENSP00000332812
PTGER3	ENSP00000349003⁴	STRING: ENSP00000349003
RGS1	ENSP00000356429⁴	STRING: ENSP00000356429
RGS19	ENSP00000333194⁴	STRING: ENSP00000333194
RGS2	ENSP00000235382⁴	STRING: ENSP00000235382
SST	ENSP00000287641⁴	STRING: ENSP00000287641
TAC1	ENSP00000321106⁴	STRING: ENSP00000321106
TRH	ENSP00000303452⁴	STRING: ENSP00000303452
ADCY1	ENSP00000297323⁴	STRING: ENSP00000297323
ADCY4	ENSP00000312126⁴	STRING: ENSP00000312126
ADCY5	ENSP00000419361⁴	STRING: ENSP00000419361
ADCY6	ENSP00000311405⁴	STRING: ENSP00000311405
ADCY7	ENSP00000254235⁴	STRING: ENSP00000254235
ADCY8	ENSP00000286355⁴	STRING: ENSP00000286355
ADORA1	ENSP00000308549⁴	STRING: ENSP00000308549
ADORA3	ENSP00000358730⁴	STRING: ENSP00000358730
ADRA1B	ENSP00000306662⁴	STRING: ENSP00000306662
ADRA1D	ENSP00000368766⁴	STRING: ENSP00000368766
ADRA2A	ENSP00000280155⁴	STRING: ENSP00000280155
ADRA2B	ENSP00000387281⁴	STRING: ENSP00000387281
ADRA2C	ENSP00000386069⁴	STRING: ENSP00000386069
ADRBK1	ENSP00000312262⁴	STRING: ENSP00000312262
AGTR1	ENSP00000273430⁴	STRING: ENSP00000273430
AGTR2	ENSP00000360973⁴	STRING: ENSP00000360973
APLN	ENSP00000305464⁴	STRING: ENSP00000305464
APLNR	ENSP00000257254⁴	STRING: ENSP00000257254
ARHGEF25	ENSP00000335560⁴	STRING: ENSP00000335560
AVPR1A	ENSP00000299178⁴	STRING: ENSP00000299178
AVPR1B	ENSP00000356094⁴	STRING: ENSP00000356094
BDKRB1	ENSP00000216629⁴	STRING: ENSP00000216629
C3AR1	ENSP00000302079⁴	STRING: ENSP00000302079
CASR	ENSP00000296154⁴	STRING: ENSP00000296154
CCKAR	ENSP00000295589⁴	STRING: ENSP00000295589
CCKBR	ENSP00000335544⁴	STRING: ENSP00000335544
CCL16	ENSP00000293275⁴	STRING: ENSP00000293275
CCL19	ENSP00000308815⁴	STRING: ENSP00000308815
CCL25	ENSP00000375086⁴	STRING: ENSP00000375086
CCL27	ENSP00000259631⁴	STRING: ENSP00000259631
CCL28	ENSP00000354416⁴	STRING: ENSP00000354416
CCR3	ENSP00000350003⁴	STRING: ENSP00000350003
CCR6	ENSP00000339393⁴	STRING: ENSP00000339393
CCR8	ENSP00000326432⁴	STRING: ENSP00000326432
CHRM1	ENSP00000306490⁴	STRING: ENSP00000306490
CHRM2	ENSP00000319984⁴	STRING: ENSP00000319984
CHRM3	ENSP00000255380⁴	STRING: ENSP00000255380
CHRM4	ENSP00000409378⁴	STRING: ENSP00000409378
CIDEB	ENSP00000337731⁴	STRING: ENSP00000337731
CXCL10	ENSP00000305651⁴	STRING: ENSP00000305651
CXCL11	ENSP00000306884⁴	STRING: ENSP00000306884
CXCL16	ENSP00000293778⁴	STRING: ENSP00000293778
CXCL9	ENSP00000354901⁴	STRING: ENSP00000354901
CXCR1	ENSP00000295683⁴	STRING: ENSP00000295683
CXCR5	ENSP00000292174⁴	STRING: ENSP00000292174
CXCR6	ENSP00000304414⁴	STRING: ENSP00000304414
CXCR7	ENSP00000272928⁴	STRING: ENSP00000272928
CYSLTR1	ENSP00000362401⁴	STRING: ENSP00000362401
DRD2	ENSP00000354859⁴	STRING: ENSP00000354859
DRD3	ENSP00000373169⁴	STRING: ENSP00000373169
DRD4	ENSP00000176183⁴	STRING: ENSP00000176183
EDN2	ENSP00000361668⁴	STRING: ENSP00000361668
EDN3	ENSP00000337128⁴	STRING: ENSP00000337128
F2RL2	ENSP00000296641⁴	STRING: ENSP00000296641
F2RL3	ENSP00000248076⁴	STRING: ENSP00000248076
FFAR1	ENSP00000246553⁴	STRING: ENSP00000246553
FFAR2	ENSP00000246549⁴	STRING: ENSP00000246549
GALR1	ENSP00000299727⁴	STRING: ENSP00000299727
GALR2	ENSP00000329684⁴	STRING: ENSP00000329684
GALR3	ENSP00000249041⁴	STRING: ENSP00000249041
GAST	ENSP00000331358⁴	STRING: ENSP00000331358
GHSR	ENSP00000241256⁴	STRING: ENSP00000241256
GNA14	ENSP00000365807⁴	STRING: ENSP00000365807
GNG2	ENSP00000334448⁴	STRING: ENSP00000334448
GNRH2	ENSP00000245983⁴	STRING: ENSP00000245983
GNRHR2	ENSP00000354569⁴	STRING: ENSP00000354569
GPER	ENSP00000297469⁴	STRING: ENSP00000297469
GPR132	ENSP00000328818⁴	STRING: ENSP00000328818
GPR17	ENSP00000272644⁴	STRING: ENSP00000272644
GPR4	ENSP00000319744⁴	STRING: ENSP00000319744
GPR55	ENSP00000375893⁴	STRING: ENSP00000375893
GPR65	ENSP00000267549⁴	STRING: ENSP00000267549
GPR68	ENSP00000238699⁴	STRING: ENSP00000238699
GPRC6A	ENSP00000309493⁴	STRING: ENSP00000309493
GRK5	ENSP00000376609⁴	STRING: ENSP00000376609
GRPR	ENSP00000369643⁴	STRING: ENSP00000369643
HCAR2	ENSP00000375066⁴	STRING: ENSP00000375066
HCRT	ENSP00000293330⁴	STRING: ENSP00000293330
HCRTR1	ENSP00000362810⁴	STRING: ENSP00000362810
HEBP1	ENSP00000014930⁴	STRING: ENSP00000014930
HRH3	ENSP00000342560⁴	STRING: ENSP00000342560
HRH4	ENSP00000256906⁴	STRING: ENSP00000256906
HTR1A	ENSP00000316244⁴	STRING: ENSP00000316244
HTR1B	ENSP00000358963⁴	STRING: ENSP00000358963
HTR1D	ENSP00000313661⁴	STRING: ENSP00000313661
HTR1E	ENSP00000307766⁴	STRING: ENSP00000307766
HTR1F	ENSP00000322924⁴	STRING: ENSP00000322924
HTR2A	ENSP00000367959⁴	STRING: ENSP00000367959
HTR2C	ENSP00000276198⁴	STRING: ENSP00000276198
HTR5A	ENSP00000287907⁴	STRING: ENSP00000287907
KISS1	ENSP00000356162⁴	STRING: ENSP00000356162
KISS1R	ENSP00000234371⁴	STRING: ENSP00000234371
LPAR1	ENSP00000351755⁴	STRING: ENSP00000351755
LPAR2	ENSP00000384665⁴	STRING: ENSP00000384665
LPAR3	ENSP00000359643⁴	STRING: ENSP00000359643
LPAR4	ENSP00000362398⁴	STRING: ENSP00000362398
LPAR6	ENSP00000344353⁴	STRING: ENSP00000344353
MCHR1	ENSP00000249016⁴	STRING: ENSP00000249016
MCHR2	ENSP00000281806⁴	STRING: ENSP00000281806
MLN	ENSP00000266003⁴	STRING: ENSP00000266003
MLNR	ENSP00000218721⁴	STRING: ENSP00000218721
MTNR1A	ENSP00000302811⁴	STRING: ENSP00000302811
MTNR1B	ENSP00000257068⁴	STRING: ENSP00000257068
NMBR	ENSP00000258042⁴	STRING: ENSP00000258042
NMS	ENSP00000366061⁴	STRING: ENSP00000366061
NMUR1	ENSP00000305877⁴	STRING: ENSP00000305877
NMUR2	ENSP00000255262⁴	STRING: ENSP00000255262
NPB	ENSP00000332766⁴	STRING: ENSP00000332766
NPBWR1	ENSP00000330284⁴	STRING: ENSP00000330284
NPBWR2	ENSP00000358783⁴	STRING: ENSP00000358783
NPFF	ENSP00000267017⁴	STRING: ENSP00000267017
NPFFR1	ENSP00000277942⁴	STRING: ENSP00000277942
NPFFR2	ENSP00000307822⁴	STRING: ENSP00000307822
NPS	ENSP00000381105⁴	STRING: ENSP00000381105
NPSR1	ENSP00000352839⁴	STRING: ENSP00000352839
NPW	ENSP00000330070⁴	STRING: ENSP00000330070
NPY1R	ENSP00000354652⁴	STRING: ENSP00000354652
NPY2R	ENSP00000332591⁴	STRING: ENSP00000332591
NPY5R	ENSP00000339377⁴	STRING: ENSP00000339377
NTS	ENSP00000256010⁴	STRING: ENSP00000256010
NTSR1	ENSP00000359532⁴	STRING: ENSP00000359532
NTSR2	ENSP00000303686⁴	STRING: ENSP00000303686
OPN4	ENSP00000361141⁴	STRING: ENSP00000361141
OPRD1	ENSP00000234961⁴	STRING: ENSP00000234961
OPRK1	ENSP00000265572⁴	STRING: ENSP00000265572
OPRL1	ENSP00000336764⁴	STRING: ENSP00000336764
OPRM1	ENSP00000394624⁴	STRING: ENSP00000394624
OXER1	ENSP00000367930⁴	STRING: ENSP00000367930
OXT	ENSP00000217386⁴	STRING: ENSP00000217386
OXTR	ENSP00000324270⁴	STRING: ENSP00000324270
P2RY1	ENSP00000304767⁴	STRING: ENSP00000304767
P2RY10	ENSP00000171757⁴	STRING: ENSP00000171757
P2RY12	ENSP00000307259⁴	STRING: ENSP00000307259
P2RY13	ENSP00000320376⁴	STRING: ENSP00000320376
P2RY14	ENSP00000308361⁴	STRING: ENSP00000308361
P2RY2	ENSP00000310305⁴	STRING: ENSP00000310305
P2RY4	ENSP00000363643⁴	STRING: ENSP00000363643
P2RY6	ENSP00000309771⁴	STRING: ENSP00000309771
PDYN	ENSP00000217305⁴	STRING: ENSP00000217305
PENK	ENSP00000324248⁴	STRING: ENSP00000324248
PIK3R1	ENSP00000274335⁴	STRING: ENSP00000274335
PIK3R2	ENSP00000222254⁴	STRING: ENSP00000222254
PIK3R3	ENSP00000262741⁴	STRING: ENSP00000262741
PLCB1	ENSP00000338185⁴	STRING: ENSP00000338185
PLCB3	ENSP00000279230⁴	STRING: ENSP00000279230
PLCB4	ENSP00000334105⁴	STRING: ENSP00000334105
PMCH	ENSP00000332225⁴	STRING: ENSP00000332225
PNOC	ENSP00000301908⁴	STRING: ENSP00000301908
PPBP	ENSP00000296028⁴	STRING: ENSP00000296028

About this table

Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001776	leukocyte homeostasis	--	--
GO:0001780	neutrophil homeostasis	IMP	--
GO:0002674	negative regulation of acute inflammatory response	IEA	--
GO:0006928	cellular component movement	TAS	10882119
GO:0006954	inflammatory response	TAS	10882119

ANXA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ANXA1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ANXA1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Ac9-25	Annexin I N-terminal peptide. Acts as a FPR1 ligand	[284040-76-2]
Ac2-26	Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation	[151988-33-9]
Ac2-12	Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation	[256447-08-2]

1 HMDB Compound for ANXA1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

3 DrugBank Compounds for ANXA1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Hydrocortisone	11beta-Hydroxycortisone (see all 16)	50-23-7	target	agonist	1712816 17139284 11142771 17016423 8060156
Dexamethasone	Desametasone (see all 9)	50-02-2	target	agonist	17644190 17076770 17158208 16883066
Amcinonide	--	51022-69-6	target	agonist	17139284 17016423 7981624

10/56 Novoseek chemical compound relationships for ANXA1 gene (see all 56) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hdmnkvldl	84.9	2	8818992 (1), 1793057 (1)
phosphatidylserine	62.1	29	8179621 (3), 7627125 (1), 12744815 (1), 15381697 (1) (see all 16)
phospholipid	59.7	33	8379935 (7), 2138536 (1), 1310621 (1), 8485141 (1) (see all 20)
calcium	55	126	11142771 (6), 9299392 (5), 18283055 (4), 1469069 (3) (see all 58)
arachidonic acid	49.2	16	2064175 (2), 8260938 (2), 2137129 (2), 12845669 (1) (see all 10)
dexamethasone	45.3	54	8256657 (6), 12236584 (5), 17644190 (4), 14668092 (3) (see all 17)
glyceraldehyde 3-phosphate	44.7	7	16220529 (1), 17268060 (1), 15274135 (1), 19899082 (1) (see all 7)
geneticin	32.2	1	7764687 (1)
phosphatidylcholine	30.4	17	16307464 (2), 12845669 (1), 7654693 (1), 1387325 (1) (see all 5)
p-opc	30	7	16307464 (3), 18237543 (2)

Search CenterWatch for drugs/clinical trials and news about ANXA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ANXA1 gene:

NM_000700.1

Unigene Cluster for ANXA1:

Annexin A1

Hs.494173 [show with all ESTs]

Unigene Representative Sequence: AK074480

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000257497(uc004ajf.1) ENST00000456643 ENST00000468639 ENST00000415424

ENST00000376911(uc004ajg.1) ENST00000495713 ENST00000489109 ENST00000491192

miRNA Products:		OriGene 3'-UTR Clone: ANXA1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANXA1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ANXA1
		SwitchGear 3'UTR luciferase reporter plasmid: ANXA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANXA1 (see all 7) OriGene shRNA RFP: ANXA1 OriGene siRNA: ANXA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANXA1
		Sirion Biotech Custom design and validation of potent shRNA sequences against ANXA1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANXA1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANXA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ANXA1 (NM_000700)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANXA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ANXA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANXA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANXA1

Additional cDNA sequence:

AB451274.1 AB451401.1 AK023330.1 AK074480.1 AK296808.1 AK311684.1 BC001275.1 BC018683.1

BC034157.1 BC035993.1 BT019896.1 BT019916.1 BT019917.1 CR407684.1 X05908.1

24/49 DOTS entries (see all 49):

DT.95080391 DT.100890399 DT.95202652 DT.100765659 DT.100890413 DT.100890422 DT.100890394 DT.100890395

DT.121161786 DT.100890415 DT.95340497 DT.95223581 DT.92045136 DT.92466092 DT.100040129 DT.100890410

DT.100890409 DT.91793108 DT.91703452 DT.91949347 DT.121161854 DT.100890404 DT.92466082 DT.92466099

24/1569 AceView cDNA sequences (see all 1569):

BQ434247 CB132717 CB136230 CB110563 BM987259 BQ775882 AL702872 BG760604

CB134061 CA418081 BE885625 BM762806 BP368115 BU615234 BM970156 BU182629

CB161300 CB155823 CA441775 AI962890 AK074480 AU138337 BQ776007 BM981135

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15a	·	15b
SP1:					-		-		-		-		-						-				-						-										-						-
SP2:																			-				-						-										-						-
SP3:					-				-		-		-						-				-						-										-
SP4:																													-										-
SP5:							-		-		-		-						-				-						-

ECgene alternative splicing isoforms for ANXA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANXA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAAGATGT

About this image

ANXA1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epicardium

Kidney

Mesenchymal Condensate Cells

Bone, Cartilage

Adipose

Visceral White Adipose

Adipose

Brain

Medulla Oblongata

Brain

Kidney

Renal Collecting Duct System

Kidney

Lung

Trachea

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

CyT49 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Dorsal forebrain-like neurons (Generation of midbra...)

Brain

N2/LSB induced-cells (Generation of midbra...)

Syncytiotrophoblast-like cells (Generation of syncyt...)

See ANXA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANXA1

SOURCE GeneReport for Unigene cluster: Hs.494173

SABiosciences Expression via Pathway-Focused PCR Array including ANXA1:

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANXA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ANXA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANXA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANXA1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANXA1 gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ANXA1¹	annexin A1	75.07(n) 78.59(a)		404271 NM_206906.1 NP_996789.1
lizard (Anolis carolinensis)	Reptilia	ANXA1⁶	--	76(a)	1 ↔ 1	2(47805415-47820443)
African clawed frog (Xenopus laevis)	Amphibia	anxa1-prov²	annexin A1	77.96(n)		BC053786.1
zebrafish (Danio rerio)	Actinopterygii	anxa1a²	annexin A1a	73.36(n)		334724 AY178793.1
fruit fly (Drosophila melanogaster)	Insecta	AnnIX³	actin binding	45(a)		93B10 --
worm (Caenorhabditis elegans)	Secernentea	nex-2³	Annexin	42(a) (best of 3)		III(10397630-10399688) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ANNAT2⁶ ANNAT5⁶ (see all 8)	annexin D5 (see all 8)	33(a) 32(a) (see all 8)	many ↔ many many ↔ many (see all 8)	5(25973815-25975726) 1(25519442-25520774)
rice (Oryza sativa)	Liliopsida	-- -- (see all 9)	annexin, putative, expressed (see all 9)	36(a) 32(a) (see all 9)	many ↔ many many ↔ many (see all 9)	9(13705487-13710510) 8(20456985-20458908)

ENSEMBL Gene Tree for ANXA1 (if available)
TreeFam Gene Tree for ANXA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANXA1 gene

ANXA3² ANXA6² ANXA5² ANXA9² ANXA2² ANXA7² ANXA8² ANXA11²

ANXA8L2² ANXA10² ANXA8L1² ANXA4² ANXA13²

15 SIMAP similar genes for ANXA1 using alignment to 6 protein entries: ANXA1_HUMAN (see all proteins):

ANXA2 ANXA2P2 DKFZp686H02120 ANXA13 ANXA7 ANXA8

ANXA11 ANXA3 ANXA4 ANXA5 ANXA8L2 ANXA6

ANXA8L1 ANXA9 ANXA10

ANXA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112765295^1,2	C,F	--	75764783(+)	`TAGTGG/ACTTTC`	1	--	us2k¹		1		NA	120
rs2310312^1,2	C,F,O,A,H	--	75764998(+)	`CAAAGC/AAAAAT`	1	--	us2k¹		24		NA NS EA WA	2694
rs139090859^1,2		--	75765039(+)	`TTTTAC/TAAAAA`	1	--	us2k¹		0	--	--	--	--
rs142395928^1,2		--	75765093(+)	`AGGAAA/TGTTCC`	1	--	us2k¹		0	--	--	--	--
rs3758355^1,2	C,H	--	75765100(+)	`TTCCAA/GTAGTT`	1	--	us2k¹		5		EA NS	1898
rs192915422^1,2		--	75765212(+)	`TATTAA/GAAAGT`	1	--	us2k¹		0	--	--	--	--
rs78590593^1,2	C	--	75765229(+)	`ACATCT/CGTCAA`	1	--	us2k¹		3		CSA WA	121
rs185181036^1,2		--	75765234(+)	`TGTCAA/GGATCA`	1	--	us2k¹		0	--	--	--	--
rs33942988^1,2	C	--	75765264(+)	`ACTTA-/ACTTGT`	1	--	us2k¹		0	--	--	--	--
rs117038162^1,2	F	--	75765351(+)	`GATTAG/CATGAT`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for ANXA1 (75766673 - 75785309 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ANXA1
1 CNV: 52859

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANXA1

DNA2.0 Custom Variant and Variant Library Synthesis for ANXA1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANXA1 for disorders           About GeneDecksing

OMIM gene information: 151690    OMIM disorders: --

20/74 diseases for ANXA1 (see all 74):    About MalaCards

b-cell non-hodgkin lymphoma non-hodgkin lymphoma squamous cell carcinoma uterine fibroid

brain edema hodgkin's lymphoma idiopathic pulmonary fibrosis laryngeal squamous cell carcinoma

hairy cell leukemia oral squamous cell carcinoma esophageal squamous cell carcinoma cystic fibrosis

pulmonary fibrosis inflammatory bowel disease sarcoidosis transitional cell carcinoma

psoriatic arthritis rheumatoid arthritis pulmonary sarcoidosis muscular dystrophy

1 disease from the University of Copenhagen DISEASES database for ANXA1:

Carcinoma

10/52 Novoseek disease relationships for ANXA1 gene (see all 52) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell	41.2	25	15447985 (3), 12242662 (2), 18297688 (2), 12679902 (2) (see all 17)
adenocarcinoma lung	38.7	5	17351649 (2), 17974280 (1)
inflammation	32.3	33	9796991 (3), 15962097 (3), 19104500 (2), 9831319 (1) (see all 21)
premalignant	27	6	10448305 (1), 19351789 (1), 19101730 (1), 14695321 (1)
tumors	24.8	58	16270603 (4), 19173988 (3), 17340616 (3), 18652761 (3) (see all 29)
prostatic intraepithelial neoplasia	23.9	4	16324197 (2), 11801547 (1)
colon adenocarcinoma	23.9	6	15526283 (3), 18541673 (2)
oral cancer	21.1	6	18297688 (2), 20371204 (1), 12870656 (1)
cancer	16.7	34	18663355 (4), 20215502 (2), 16324197 (2), 20371204 (1) (see all 15)
metastasis	16.6	22	18535914 (3), 20353277 (3), 18776816 (3), 18223218 (2) (see all 11)

Genetic Association Database (GAD): ANXA1
Human Genome Epidemiology (HuGE) Navigator: ANXA1 (6 documents)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ANXA1 gene, integrated from 9 sources (see all 516):
(articles sorted by number of sources associating them with ANXA1)

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Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PubMed id 2936963)^{1, 2, 3} Wallner B.P.... Pepinsky R.B. (1986)
Crystal structure of human annexin I at 2.5-A resolution. (PubMed id 8453382)^{1, 2, 9} Weng X.... Huber R. (1993)
Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PubMed id 16883066)^{1, 7, 9} Morand E.F....Yang Y.H. (2006)
Phosphorylation of annexin I by TRPM7 channel-kinase. (PubMed id 15485879)^{1, 2} Dorovkov M.V. and Ryazanov A.G. (2004)
[Absence of evidence for the association of single nucleotide polymorphisms in Annexin A1 gene with type 2 diabetes in Chinese] (PubMed id 15476183)^{1, 4} Dong Y....Luo M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of the annexin I gene and evaluation of its role in type 2 diabetes. (PubMed id 11574426)^{1, 4} Lindgren C.M....Groop L.C. (2001)
NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit. (PubMed id 9915835)^{1, 2} Gao J.... Yan H. (1999)
Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. (PubMed id 8425544)^{1, 2} Arcone R.... Ciliberto G. (1993)
Correlation of gene and protein structure of rat and human lipocortin I. (PubMed id 1832554)^{1, 2} Kovacic R.T.... Wallner B.P. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 301	HGNC: 533	AceView: ANXA1	Ensembl:ENSG00000135046	euGenes: HUgn301
ECgene: ANXA1	H-InvDB: ANXA1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ANXA1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ANXA1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ANXA1 gene
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Patent Information for ANXA1 gene:
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