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Aliases for ANXA1 Gene

Aliases for ANXA1 Gene

  • Annexin A1 2 3
  • LPC1 3 4 6
  • Phospholipase A2 Inhibitory Protein 3 4
  • Chromobindin-9 3 4
  • Calpactin II 3 4
  • Calpactin-2 3 4
  • Annexin-1 3 4
  • ANX1 3 4
  • Annexin I (Lipocortin I) 3
  • Lipocortin I 4
  • Annexin I 4
  • P35 4

External Ids for ANXA1 Gene

Previous HGNC Symbols for ANXA1 Gene

  • ANX1
  • LPC1

Previous GeneCards Identifiers for ANXA1 Gene

  • GC09P066811
  • GC09P067623
  • GC09P069336
  • GC09P071223
  • GC09P072996
  • GC09P074956
  • GC09P075766
  • GC09P045589

Summaries for ANXA1 Gene

Entrez Gene Summary for ANXA1 Gene

  • This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]

GeneCards Summary for ANXA1 Gene

ANXA1 (Annexin A1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include calcium ion binding and phospholipid binding. An important paralog of this gene is ANXA9.

UniProtKB/Swiss-Prot for ANXA1 Gene

  • Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Tocris Summary for ANXA1 Gene

Gene Wiki entry for ANXA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA1 Gene

Genomics for ANXA1 Gene

Genomic Location for ANXA1 Gene

Start:
73,151,757 bp from pter
End:
73,170,393 bp from pter
Size:
18,637 bases
Orientation:
Plus strand

Genomic View for ANXA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANXA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA1 Gene

Proteins for ANXA1 Gene

  • Protein details for ANXA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04083-ANXA1_HUMAN
    Recommended name:
    Annexin A1
    Protein Accession:
    P04083
    Secondary Accessions:

    Protein attributes for ANXA1 Gene

    Size:
    346 amino acids
    Molecular mass:
    38714 Da
    Quaternary structure:
    • Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity).

    Three dimensional structures from OCA and Proteopedia for ANXA1 Gene

neXtProt entry for ANXA1 Gene

Proteomics data for ANXA1 Gene at MOPED

Post-translational modifications for ANXA1 Gene

  • Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.
  • Ubiquitination at Lys58, Lys166, and Lys274
  • Glycosylation at Ser37
  • Modification sites at PhosphoSitePlus

Other Protein References for ANXA1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANXA1 (ANXA1)

No data available for DME Specific Peptides for ANXA1 Gene

Domains for ANXA1 Gene

Gene Families for ANXA1 Gene

HGNC:

Protein Domains for ANXA1 Gene

Suggested Antigen Peptide Sequences for ANXA1 Gene

Graphical View of Domain Structure for InterPro Entry

P04083

UniProtKB/Swiss-Prot:

ANXA1_HUMAN :
  • P04083
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid
Family:
  • Belongs to the annexin family.
Similarity:
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA1: view

Function for ANXA1 Gene

Molecular function for ANXA1 Gene

GENATLAS Biochemistry:
annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of the organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid feadback action in the hypothalamo-hypophysial system
UniProtKB/Swiss-Prot Function:
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Gene Ontology (GO) - Molecular Function for ANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IEA --
GO:0003727 single-stranded RNA binding IEA --
GO:0004386 helicase activity IEA --
GO:0004859 phospholipase inhibitor activity --
GO:0005102 receptor binding TAS 10882119
genes like me logo Genes that share ontologies with ANXA1: view
genes like me logo Genes that share phenotypes with ANXA1: view

Animal Model Products

miRNA for ANXA1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANXA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANXA1 Gene

Localization for ANXA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA1 Gene

Nucleus. Cytoplasm. Cell projection, cilium. Basolateral cell membrane. Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium. Found in the cytoplasm of type II pneumocytes and alveolar macrophages. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA1 Gene COMPARTMENTS Subcellular localization image for ANXA1 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 4
plasma membrane 4
endosome 2
mitochondrion 2
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IDA 10908733
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA 22056994
GO:0005737 cytoplasm TAS 16130169
genes like me logo Genes that share ontologies with ANXA1: view

Pathways for ANXA1 Gene

genes like me logo Genes that share pathways with ANXA1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000733 DNA strand renaturation IEA --
GO:0001780 neutrophil homeostasis IMP 21957127
GO:0006200 obsolete ATP catabolic process --
GO:0006928 movement of cell or subcellular component TAS 10882119
GO:0006954 inflammatory response TAS 10882119
genes like me logo Genes that share ontologies with ANXA1: view

Compounds for ANXA1 Gene

(1) HMDB Compounds for ANXA1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Drugbank Compounds for ANXA1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Amcinonide
51022-69-6 target agonist
Dexamethasone
  • Desametasone
50-02-2 target agonist
Hydrocortisone
  • 11beta-Hydroxycortisone
50-23-7 target agonist

(56) Novoseek inferred chemical compound relationships for ANXA1 Gene

Compound -log(P) Hits PubMed IDs
hdmnkvldl 84.9 2
phosphatidylserine 62.1 18
phospholipid 59.7 26
calcium 55 95
arachidonic acid 49.2 13
genes like me logo Genes that share compounds with ANXA1: view

Transcripts for ANXA1 Gene

Unigene Clusters for ANXA1 Gene

Annexin A1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANXA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - - - -
SP10: - - -
SP11:
SP12: -
SP13:

Relevant External Links for ANXA1 Gene

GeneLoc Exon Structure for
ANXA1
ECgene alternative splicing isoforms for
ANXA1

Expression for ANXA1 Gene

mRNA expression in normal human tissues for ANXA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA1 Gene

This gene is overexpressed in Esophagus - Mucosa (19.5) and Minor Salivary Gland (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA1 Gene

SOURCE GeneReport for Unigene cluster for ANXA1 Gene Hs.494173

genes like me logo Genes that share expressions with ANXA1: view

Expression partners for ANXA1 Gene

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANXA1 Gene

Orthologs for ANXA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANXA1 35
  • 88.57 (n)
  • 90.99 (a)
ANXA1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA1 35
  • 89.53 (n)
  • 91.86 (a)
ANXA1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa1 35
  • 86.61 (n)
  • 87.57 (a)
Anxa1 16
Anxa1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANXA1 35
  • 99.42 (n)
  • 99.71 (a)
ANXA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa1 35
  • 86.13 (n)
  • 89.02 (a)
oppossum
(Monodelphis domestica)
Mammalia ANXA1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANXA1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANXA1 35
  • 75.07 (n)
  • 78.59 (a)
ANXA1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa1 35
  • 69.73 (n)
  • 69.44 (a)
MGC76270 35
African clawed frog
(Xenopus laevis)
Amphibia anxa1-prov 35
zebrafish
(Danio rerio)
Actinopterygii anxa1a 35
  • 65.49 (n)
  • 65.49 (a)
ANXA1 (4 of 4) 36
  • 52 (a)
OneToMany
anxa1a 36
  • 66 (a)
OneToMany
anxa1b 36
  • 52 (a)
OneToMany
anxa1c 36
  • 51 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8605 35
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea nex-1 37
  • 37 (a)
nex-2 37
  • 42 (a)
nex-3 37
  • 35 (a)
nex-1 36
  • 36 (a)
ManyToMany
nex-3 36
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
ManyToMany
Species with no ortholog for ANXA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA1 Gene

ENSEMBL:
Gene Tree for ANXA1 (if available)
TreeFam:
Gene Tree for ANXA1 (if available)

Paralogs for ANXA1 Gene

Paralogs for ANXA1 Gene

genes like me logo Genes that share paralogs with ANXA1: view

Variants for ANXA1 Gene

Sequence variations from dbSNP and Humsavar for ANXA1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs9561 -- 73,170,189(+) AGTTT(C/T)TTCAA utr-variant-3-prime
rs1050305 -- 73,160,319(+) GTTTT(A/G)GCTCT reference, synonymous-codon
rs1131072 -- 73,151,922(+) AGATA(A/G)AGGTA utr-variant-5-prime
rs1342017 -- 73,167,594(-) TAATT(C/T)TTCCT intron-variant
rs1342018 -- 73,167,215(-) TATTC(C/T)CCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA1 Gene

Variant ID Type Subtype PubMed ID
nsv893452 CNV Gain 21882294
nsv526225 CNV Gain 19592680
nsv6561 CNV Insertion 18451855
nsv519796 CNV Gain 19592680

Relevant External Links for ANXA1 Gene

HapMap Linkage Disequilibrium report
ANXA1
Human Gene Mutation Database (HGMD)
ANXA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA1 Gene

Disorders for ANXA1 Gene

(1) University of Copenhagen DISEASES for ANXA1 Gene

(52) Novoseek inferred disease relationships for ANXA1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 41.2 23
adenocarcinoma lung 38.7 3
inflammation 32.3 26
premalignant 27 4
tumors 24.8 42

Relevant External Links for ANXA1

Genetic Association Database (GAD)
ANXA1
Human Genome Epidemiology (HuGE) Navigator
ANXA1
genes like me logo Genes that share disorders with ANXA1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for ANXA1 Gene

Publications for ANXA1 Gene

  1. Crystal structure of human annexin I at 2.5-A resolution. (PMID: 8453382) Weng X. … Huber R. (Protein Sci. 1993) 3 4 23
  2. Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PMID: 2936963) Wallner B.P. … Pepinsky R.B. (Nature 1986) 2 3 4
  3. Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PMID: 16883066) Morand E.F. … Yang Y.H. (Mediators Inflamm. 2006) 3 23 25
  4. Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells. (PMID: 20308542) de Graauw M. … van de Water B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  5. Annexin A1 expression and its prognostic significance in human breast cancer. (PMID: 20353277) Wang L.P. … Chang G.Q. (Neoplasma 2010) 3 23

Products for ANXA1 Gene

Sources for ANXA1 Gene

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