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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANXA1 Gene

protein-coding   GIFtS: 71
GCID: GC09P075766

Annexin A1


(Previous symbols: ANX1, LPC1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Annexin A11 2     annexin-12
LPC11 2 3 5     calpactin-22
ANX11 2 3     chromobindin-92
Calpactin II2 3     Annexin-13
Lipocortin I2 3     Calpactin-23
Phospholipase A2 Inhibitory Protein2 3     Chromobindin-93
p352 3     Annexin I3
Annexin I (Lipocortin I)2     

External Ids:    HGNC: 5331   Entrez Gene: 3012   Ensembl: ENSG000001350467   OMIM: 1516905   UniProtKB: P040833   

Export aliases for ANXA1 gene to outside databases

Previous GC identifers: GC09P066811 GC09P067623 GC09P069336 GC09P071223 GC09P072996 GC09P074956 GC09P045589


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANXA1 Gene:
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of
approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane.
Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity.
Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins
and leukotrienes, annexin I may have potential anti-inflammatory activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for ANXA1 Gene: 
ANXA1 (annexin A1) is a protein-coding gene. Diseases associated with ANXA1 include brain edema, and colon adenocarcinoma, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include phospholipid binding and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Gene Wiki entry for ANXA1 (Annexin A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANXA1 gene promoter:
         C/EBPbeta   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   AREB6   POU2F1   POU2F1a   STAT3   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ANXA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANXA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q21.13

ANXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P075766:  view genomic region     (about GC identifiers)

Start:
75,766,673 bp from pter      End:
75,785,309 bp from pter
Size:
18,637 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083 (See protein sequence)
Recommended Name: Annexin A1  
Size: 346 amino acids; 38714 Da
Subunit: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity).
Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of
ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and
alveolar macrophages (By similarity)
3 PDB 3D structures from and Proteopedia for ANXA1:
1AIN (3D)        1BO9 (3D)        1QLS (3D)    

Explore the universe of human proteins at neXtProt for ANXA1: NX_P04083

Explore proteomics data for ANXA1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in
    loss of the inhibitory activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04083

  • ANXA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANXA1 Protein Expression
    REFSEQ proteins: NP_000691.1  
    ENSEMBL proteins: 
     ENSP00000257497   ENSP00000412489   ENSP00000414013   ENSP00000366109  
    Reactome Protein details: P04083
    Human Recombinant Protein Products for ANXA1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ANXA1 (Annexin A1)
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    OriGene Purified Protein for ANXA1
    OriGene Protein Over-expression Lysate for ANXA1
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    Novus Biologicals ANXA1 Proteins
    Novus Biologicals ANXA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ANXA1
    Cloud-Clone Corp. Proteins for ANXA1 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001533cornified envelope IDA10908733
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS16130169

    ANXA1 for ontologies           About GeneDecksing



    ANXA1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANXA1
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    Assay Products for ANXA1: 
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    Cloud-Clone Corp. CLIAs for ANXA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    ANXA: Annexins

    4 InterPro protein domains:
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR002388 AnnexinI
     IPR018502 Annexin_repeat

    Graphical View of Domain Structure for InterPro Entry P04083

    ProtoNet protein and cluster: P04083

    2 Blocks protein domains:
    IPB001464 Annexin
    IPB002388 Annexin type I signature


    UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    ANXA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANXA1_HUMAN, P04083
    Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
    protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

         Genatlas biochemistry entry for ANXA1:
    annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of
    the organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid
    feadback action in the hypothalamo-hypophysial system

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity ----
    GO:0005102receptor binding TAS10882119
    GO:0005198structural molecule activity IDA10908733
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
         
    ANXA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ANXA1:
     Decreased viability 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Anxa1):
     adipose tissue  cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     skeleton  tumorigenesis 

    ANXA1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ANXA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ANXA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANXA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANXA1 

    miRNA
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    miRTarBase miRNAs that target ANXA1:
    hsa-mir-196a (MIRT000709)

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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ANXA1
    SwitchGear 3'UTR luciferase reporter plasmidANXA1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ANXA1 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Spinal Cord Injury
    Spinal Cord Injury
    5Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ANXA1
        Selected targets of CREB1
    Selected targets of C/EBPalpha


    1 Cell Signaling Technology (CST) Pathway for ANXA1
        Ca, cAMP and Lipid Signaling

    4 BioSystems Pathways for ANXA1
        Integrated Breast Cancer Pathway
    Spinal Cord Injury
    Prostaglandin Synthesis and Regulation
    Integrated Pancreatic Cancer Pathway


    5/10        Reactome Pathways for ANXA1 (see all 10)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    ANXA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANXA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/309 Interacting proteins for ANXA1 (P040831, 2, 3 ENSP000002574974) via UniProtKB, MINT, STRING, and/or I2D (see all 309)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBB1O002132, 3, ENSP000002994024MINT-8247707 I2D: score=2 STRING: ENSP00000299402
    C14orf1Q9UKR52, 3MINT-8247720 I2D: score=2 
    CCT7Q998322, 3MINT-8247753 I2D: score=2 
    COPS6Q7L5N12, 3MINT-8247764 I2D: score=2 
    CSADQ9Y6002, 3MINT-8247775 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001780neutrophil homeostasis IMP--
    GO:0002674negative regulation of acute inflammatory response IEA--
    GO:0006928cellular component movement TAS10882119
    GO:0006954inflammatory response TAS10882119
    GO:0007049cell cycle IEA--

    ANXA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANXA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ANXA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ThiolutinBacterial RNA polymerase inhibitor[87-11-6]
    Heparin sodium saltAnticoagulant[9041-08-1]
    Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor[154303-05-6]
    RGDS peptideIntegrin binding sequence; inhibits integrin receptor function[91037-65-9]
    Ac2-26Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation[151988-33-9]

    1 HMDB Compound for ANXA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for ANXA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Hydrocortisone11beta-Hydroxycortisone (see all 16)50-23-7targetagonist1712816 17139284 11142771 17016423 8060156
    DexamethasoneDesametasone (see all 9)50-02-2targetagonist17644190 17076770 17158208 16883066
    Amcinonide-- 51022-69-6targetagonist17139284 17016423 7981624

    10/56 Novoseek inferred chemical compound relationships for ANXA1 gene (see all 56)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hdmnkvldl 84.9 2 8818992 (1), 1793057 (1)
    phosphatidylserine 62.1 29 8179621 (3), 7627125 (1), 12744815 (1), 15381697 (1) (see all 16)
    phospholipid 59.7 33 8379935 (7), 2138536 (1), 1310621 (1), 8485141 (1) (see all 20)
    calcium 55 126 11142771 (6), 9299392 (5), 18283055 (4), 1469069 (3) (see all 58)
    arachidonic acid 49.2 16 2064175 (2), 8260938 (2), 2137129 (2), 12845669 (1) (see all 10)
    dexamethasone 45.3 54 8256657 (6), 12236584 (5), 17644190 (4), 14668092 (3) (see all 17)
    glyceraldehyde 3-phosphate 44.7 7 16220529 (1), 17268060 (1), 15274135 (1), 19899082 (1) (see all 7)
    geneticin 32.2 1 7764687 (1)
    phosphatidylcholine 30.4 17 16307464 (2), 12845669 (1), 7654693 (1), 1387325 (1) (see all 5)
    p-opc 30 7 16307464 (3), 18237543 (2)

    Search CenterWatch for drugs/clinical trials and news about ANXA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ANXA1 gene: 
    NM_000700.1  

    Unigene Cluster for ANXA1:

    Annexin A1
    Hs.494173  [show with all ESTs]
    Unigene Representative Sequence: AK074480
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257497(uc004ajf.1) ENST00000468639 ENST00000456643 ENST00000415424
    ENST00000376911(uc004ajg.1) ENST00000495713 ENST00000489109 ENST00000491192


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    Additional mRNA sequence: 

    AB451274.1 AB451401.1 AK023330.1 AK074480.1 AK296808.1 AK311684.1 BC001275.1 BC018683.1 
    BC034157.1 BC035993.1 BT019896.1 BT019916.1 BT019917.1 CR407684.1 X05908.1 

    24/49 DOTS entries (see all 49):

    DT.95080391  DT.100890399  DT.95202652  DT.100765659  DT.100890413  DT.100890422  DT.100890394  DT.100890395 
    DT.121161786  DT.100890415  DT.95340497  DT.95223581  DT.92045136  DT.92466092  DT.100040129  DT.100890410 
    DT.100890409  DT.91793108  DT.91703452  DT.91949347  DT.121161854  DT.100890404  DT.92466082  DT.92466099 

    24/1569 AceView cDNA sequences (see all 1569):

    CA415613 CB134453 CB116281 BU676623 BC001275 CB136196 BM987115 CB125606 
    BG680014 CB149662 CB120109 AA348570 AI923018 CB110454 CB132713 BF981334 
    CB113203 BM550642 CB110876 BF218920 CA447223 CA445329 BU506807 AK023330 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:              -     -     -     -     -                 -           -                 -                             -                 -                     
    SP2:                                                        -           -                 -                             -                 -                     
    SP3:              -           -     -     -                 -           -                 -                             -                                       
    SP4:                                                                                      -                             -                                       
    SP5:                    -     -     -     -                 -           -                 -                                                                     


    ECgene alternative splicing isoforms for ANXA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANXA1 expression in normal human tissues (normalized intensities)      ANXA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAAGATGT
    ANXA1 Expression
    About this image


    ANXA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Lung (Respiratory System)    fully expand to see all 6 entries
             Trachea
             lung ; pneumocytes   
             visceral organ/lung/right lung   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Cerebral Cortex
             Ciliary Ganglion   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See ANXA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANXA1

    SOURCE GeneReport for Unigene cluster: Hs.494173
        SABiosciences Expression via Pathway-Focused PCR Array including ANXA1: 
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ANXA1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anxa11 , 5 annexin A11, 5 86.61(n)1
    87.57(a)1
      19 (13.83 cM)5
    169521  NM_010730.21  NP_034860.21 
     203734285 
    chicken
    (Gallus gallus)
    Aves ANXA11 annexin A1 75.07(n)
    78.59(a)
      404271  NM_206906.1  NP_996789.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA16
    Annexin
    76(a)
    1 ↔ 1
    2(47804835-47822960)
    African clawed frog
    (Xenopus laevis)
    Amphibia anxa1-prov2 annexin A1 77.96(n)    BC053786.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anxa1a2 annexin A1a 73.36(n)   334724  AY178793.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nex-23 Annexin 42(a)
    (best of 3)
      III(10397630-10399688)   --


    ENSEMBL Gene Tree for ANXA1 (if available)
    TreeFam Gene Tree for ANXA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANXA1 gene
    ANXA32  ANXA62  ANXA52  ANXA92  ANXA22  ANXA72  ANXA82  ANXA112  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA1 using alignment to 6 protein entries:     ANXA1_HUMAN (see all proteins):
    ANXA2    ANXA2P2    DKFZp686H02120    ANXA13    ANXA7    ANXA11
    ANXA3    ANXA8L1    ANXA4    ANXA5    ANXA8L2    ANXA8
    ANXA6    ANXA9    ANXA10

    ANXA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/449 SNPs in ANXA1 are shown (see all 449)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127652951,2
    C,F--75764783(+) TAGTGG/ACTTTC 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs23103121,2
    C,F,O,A,H--75764998(+) CAAAGC/AAAAAT 1 -- us2k124Minor allele frequency- A:0.19NA NS EA WA 2694
    rs1390908591,2
    --75765039(+) TTTTAC/TAAAAA 1 -- us2k10--------
    rs1423959281,2
    --75765093(+) AGGAAA/TGTTCC 1 -- us2k10--------
    rs37583551,2
    C,F,H--75765100(+) TTCCAA/GTAGTT 1 -- us2k15Minor allele frequency- G:0.02EA NS 1898
    rs1929154221,2
    --75765212(+) TATTAA/GAAAGT 1 -- us2k10--------
    rs785905931,2
    C--75765229(+) ACATCT/CGTCAA 1 -- us2k13Minor allele frequency- C:0.08CSA WA 121
    rs1851810361,2
    --75765234(+) TGTCAA/GGATCA 1 -- us2k10--------
    rs339429881,2
    C--75765264(+) ACTTA-/ACTTGT 1 -- us2k10--------
    rs1170381621,2
    F--75765351(+) GATTAG/CATGAT 1 -- us2k11Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for ANXA1 (75766673 - 75785309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ANXA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6561CNV Insertion18451855
    nsv526225CNV Gain19592680
    nsv519796CNV Gain19592680
    nsv893452CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 151690    OMIM disorders: --

    20/69 diseases for ANXA1 (see all 69):    About MalaCards
    brain edema    colon adenocarcinoma    uterine fibroid    oral cancer
    prostate adenocarcinoma    hairy cell leukemia    sarcoidosis    pulmonary sarcoidosis
    non-hodgkin lymphoma    hodgkin's lymphoma    lung adenocarcinoma    psoriatic arthritis
    idiopathic pulmonary fibrosis    stomach cancer    oral squamous cell carcinoma    adenocarcinoma
    endocarditis    laryngeal squamous cell carcinoma    esophageal squamous cell carcinoma    pulmonary fibrosis

    1 disease from the University of Copenhagen DISEASES database for ANXA1:
    Carcinoma

    ANXA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/52 Novoseek inferred disease relationships for ANXA1 gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 41.2 25 15447985 (3), 12242662 (2), 18297688 (2), 12679902 (2), 18652761 (2), 1348694 (1), 18673418 (1), 1445299 (1), 12500389 (1), 17884789 (1), 17340616 (1), 14695321 (1), 2137129 (1), 1670773 (1), 16270603 (1), 17974280 (1), 20371204 (1) (see top 4)
    adenocarcinoma lung 38.7 5 17351649 (2), 17974280 (1)
    inflammation 32.3 33 9796991 (3), 15962097 (3), 19104500 (2), 9831319 (1), 15070421 (1), 20107188 (1), 19847291 (1), 16944961 (1), 19294693 (1), 15060718 (1), 14519120 (1), 12467520 (1), 19233564 (1), 15157173 (1), 20215502 (1), 11729999 (1), 19647486 (1), 12870656 (1), 18535914 (1), 14607080 (1), 16014420 (1) (see top 4)
    premalignant 27 6 10448305 (1), 19351789 (1), 19101730 (1), 14695321 (1)
    tumors 24.8 58 16270603 (4), 19173988 (3), 17340616 (3), 18652761 (3), 12242662 (2), 14587099 (2), 16899607 (2), 20353277 (2), 2138568 (1), 17019707 (1), 9831187 (1), 15447985 (1), 20163912 (1), 18776816 (1), 18663355 (1), 15012775 (1), 19833546 (1), 18541673 (1), 14733945 (1), 8387039 (1), 19737943 (1), 14695321 (1), 16741918 (1), 11083278 (1), 19351789 (1), 17131471 (1), 9062391 (1), 17268060 (1), 17882654 (1) (see top 4)
    prostatic intraepithelial neoplasia 23.9 4 16324197 (2), 11801547 (1)
    colon adenocarcinoma 23.9 6 15526283 (3), 18541673 (2)
    oral cancer 21.1 6 18297688 (2), 20371204 (1), 12870656 (1)
    cancer 16.7 34 18663355 (4), 20215502 (2), 16324197 (2), 20371204 (1), 12242662 (1), 15070421 (1), 18396684 (1), 19833546 (1), 18637184 (1), 17932043 (1), 20023747 (1), 16707281 (1), 12536071 (1), 16270603 (1), 17131471 (1) (see top 4)
    metastasis 16.6 22 18535914 (3), 20353277 (3), 18776816 (3), 18223218 (2), 17974280 (1), 15975278 (1), 16675446 (1), 14695321 (1), 20308542 (1), 9514092 (1), 16899607 (1) (see top 4)

    Genetic Association Database (GAD): ANXA1
    Human Genome Epidemiology (HuGE) Navigator: ANXA1 (6 documents)

    Export disorders for ANXA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANXA1 gene, integrated from 9 sources (see all 541):
    (articles sorted by number of sources associating them with ANXA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PubMed id 2936963)1, 2, 3 Wallner B.P.... Pepinsky R.B. (1986)
    2. Crystal structure of human annexin I at 2.5-A resolution. (PubMed id 8453382)1, 2, 9 Weng X.... Huber R. (1993)
    3. Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PubMed id 16883066)1, 7, 9 Morand E.F....Yang Y.H. (2006)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Phosphorylation of annexin I by TRPM7 channel-kinase. (PubMed id 15485879)1, 2 Dorovkov M.V. and Ryazanov A.G. (2004)
    6. [Absence of evidence for the association of single nucleotide polymorphisms in Annexin A1 gene with type 2 diabetes in Chinese] (PubMed id 15476183)1, 4 Dong Y....Luo M. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Characterization of the annexin I gene and evaluation of its role in type 2 diabetes. (PubMed id 11574426)1, 4 Lindgren C.M....Groop L.C. (2001)
    9. NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit. (PubMed id 9915835)1, 2 Gao J.... Yan H. (1999)
    10. Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. (PubMed id 8425544)1, 2 Arcone R.... Ciliberto G. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 301 HGNC: 533 AceView: ANXA1 Ensembl:ENSG00000135046 euGenes: HUgn301
    ECgene: ANXA1 H-InvDB: ANXA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANXA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANXA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANXA1 gene:
    Search GeneIP for patents involving ANXA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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