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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANXA1 Gene

protein-coding GIFtS: 71
GCID: GC09P075766

annexin A1

(Previous symbols: ANX1, LPC1)

Explore 74 diseases affiliated with
ANXA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Annexin A1¹ ²		Annexin-1³
LPC1¹ ² ³ ⁵		Calpactin-2³
ANX1¹ ² ³		Chromobindin-9³
Calpactin II² ³		Annexin-1³
Lipocortin I² ³		Calpactin-2³
Phospholipase A2 Inhibitory Protein² ³		Chromobindin-9³
P35¹		Annexin I³
Annexin I (Lipocortin I)²

External Ids:	HGNC: 533¹	Entrez Gene: 301²	Ensembl: ENSG00000135046⁷	OMIM: 151690⁵	UniProtKB: P04083³

Export aliases for ANXA1 gene to outside databases

Previous GC identifers: GC09P066811 GC09P067623 GC09P069336 GC09P071223 GC09P072996 GC09P074956 GC09P045589

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANXA1:

Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of

approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I

protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since

phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and

leukotrienes, annexin I may have potential anti-inflammatory activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083

Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This

protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Gene Wiki entry for ANXA1 (Annexin A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANXA1 gene promoter:
C/EBPbeta POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 C/EBPalpha AREB6 POU2F1 POU2F1a STAT3 TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ANXA1 promoter sequence

Search SABiosciences Chromatin IP Primers for ANXA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANXA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13 Ensembl cytogenetic band: 9q21.13 HGNC cytogenetic band: 9q21.13

ANXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P075766: view genomic region (about GC identifiers)

Start:	75,766,673 bp from pter	End:	75,785,309 bp from pter
Size:	18,637 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083 (See protein sequence)

Recommended Name: Annexin A1

Size: 346 amino acids; 38714 Da

Subunit: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity)

Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity).

Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated

cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar

macrophages (By similarity)

3 PDB 3D structures from and Proteopedia for ANXA1:

1BO9 (3D)

1QLS (3D)

Explore the universe of human proteins at neXtProt for ANXA1: NX_P04083

Post-translational modifications:

Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss

of the inhibitory activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04083

ANXA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000691.1

ENSEMBL proteins:

ENSP00000257497 ENSP00000412489 ENSP00000414013 ENSP00000366109

Reactome Protein details: P04083
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for ANXA1
	Uscn Proteins for ANXA1

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001533	cornified envelope	IDA	10908733
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IEA	--

ANXA1 for ontologies About GeneDecksing

ANXA1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ANXA1
	R&D Systems Antibodies for ANXA1 (Annexin A1)
	Cell Signaling Technology (CST) Antibodies for ANXA1
	OriGene Antibodies (see all 3): ANXA1 OriGene Custom Antibody Services for ANXA1
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	Novus Biologicals ANXA1 Antibodies
	Abcam antibodies for ANXA1
	Uscn Antibodies for ANXA1
	ThermoFisher Antibody for ANXA1

Assay Products for ANXA1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ANXA1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ANXA1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANXA1 for domains About GeneDecksing

4 InterPro domains/families:

IPR001464 Annexin

IPR018252 Annexin_repeat_CS

IPR002388 AnnexinI

IPR018502 Annexin_repeat

Graphical View of Domain Structure for InterPro Entry P04083

ProtoNet protein and cluster: P04083

2 Blocks protein families:

IPB001464 Annexin

IPB002388 Annexin type I signature

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083

Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid

Similarity: Belongs to the annexin family

Similarity: Contains 4 annexin repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083

Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This

protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Genatlas biochemistry entry for ANXA1:

annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of the

organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid feadback

action in the hypothalamo-hypophysial system

miRNA Products:		miRTarBase miRNAs that target ANXA1: hsa-mir-196a (MIRT000709)

		OriGene 3'-UTR Clone: ANXA1 Browse MicroRNA Expression Plasmids
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		SwitchGear 3'UTR luciferase reporter plasmid: ANXA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANXA1 (see all 7) OriGene shRNA RFP: ANXA1 OriGene siRNA: ANXA1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ANXA1

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ANXA1
		Search LifeMap BioReagents cell lines for ANXA1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1

Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003697	single-stranded DNA binding	--	--
GO:0003727	single-stranded RNA binding	--	--
GO:0004859	phospholipase inhibitor activity	--	--
GO:0005102	receptor binding	TAS	10882119
GO:0005198	structural molecule activity	IDA	10908733

ANXA1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ANXA1:

Decreased viability

Animal Models:
12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Anxa1):

adipose tissue	cardiovascular system	craniofacial	digestive/alimentary	endocrine/exocrine gland
growth/size	homeostasis/metabolism	immune system	mortality/aging	nervous system
skeleton	tumorigenesis

ANXA1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

1

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75			G alpha (i) signalling events	0.44

2

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

3

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

4

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

5

Ca, cAMP and Lipid Signaling

Ca, cAMP and Lipid Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ANXA1

	Selected targets of CREB1
	Selected targets of C/EBPalpha

1 Cell Signaling Technology (CST) Pathway for ANXA1

Ca, cAMP and Lipid Signaling

4 BioSystems Pathways for ANXA1

	Integrated Breast Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Prostaglandin Synthesis and Regulation

5/10 Reactome Pathways for ANXA1 (see all 10)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

ANXA1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ANXA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/309 Interacting proteins for ANXA1 (P04083^{1, 2, 3} ENSP00000257497⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 309)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APBB1	O00213²^,³, ENSP00000299402⁴	MINT-8247707 I2D: score=2 STRING: ENSP00000299402
C14orf1	Q9UKR5²^,³	MINT-8247720 I2D: score=2
CCT7	Q99832²^,³	MINT-8247753 I2D: score=2
COPS6	Q7L5N1²^,³	MINT-8247764 I2D: score=2
CSAD	Q9Y600²^,³	MINT-8247775 I2D: score=2

About this table

Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001776	leukocyte homeostasis	--	--
GO:0001780	neutrophil homeostasis	IMP	--
GO:0002674	negative regulation of acute inflammatory response	IEA	--
GO:0006928	cellular component movement	TAS	10882119
GO:0006954	inflammatory response	TAS	10882119

ANXA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ANXA1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ANXA1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Ac9-25	Annexin I N-terminal peptide. Acts as a FPR1 ligand	[284040-76-2]
Ac2-26	Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation	[151988-33-9]
Ac2-12	Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation	[256447-08-2]

1 HMDB Compound for ANXA1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

3 DrugBank Compounds for ANXA1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Hydrocortisone	11beta-Hydroxycortisone (see all 16)	50-23-7	target	agonist	1712816 17139284 11142771 17016423 8060156
Dexamethasone	Desametasone (see all 9)	50-02-2	target	agonist	17644190 17076770 17158208 16883066
Amcinonide	--	51022-69-6	target	agonist	17139284 17016423 7981624

10/56 Novoseek chemical compound relationships for ANXA1 gene (see all 56) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hdmnkvldl	84.9	2	8818992 (1), 1793057 (1)
phosphatidylserine	62.1	29	8179621 (3), 7627125 (1), 12744815 (1), 15381697 (1) (see all 16)
phospholipid	59.7	33	8379935 (7), 2138536 (1), 1310621 (1), 8485141 (1) (see all 20)
calcium	55	126	11142771 (6), 9299392 (5), 18283055 (4), 1469069 (3) (see all 58)
arachidonic acid	49.2	16	2064175 (2), 8260938 (2), 2137129 (2), 12845669 (1) (see all 10)
dexamethasone	45.3	54	8256657 (6), 12236584 (5), 17644190 (4), 14668092 (3) (see all 17)
glyceraldehyde 3-phosphate	44.7	7	16220529 (1), 17268060 (1), 15274135 (1), 19899082 (1) (see all 7)
geneticin	32.2	1	7764687 (1)
phosphatidylcholine	30.4	17	16307464 (2), 12845669 (1), 7654693 (1), 1387325 (1) (see all 5)
p-opc	30	7	16307464 (3), 18237543 (2)

Search CenterWatch for drugs/clinical trials and news about ANXA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ANXA1 gene:

Unigene Cluster for ANXA1:

Annexin A1

Hs.494173 [show with all ESTs]

Unigene Representative Sequence: AK074480

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000257497(uc004ajf.1) ENST00000456643 ENST00000468639 ENST00000415424

ENST00000376911(uc004ajg.1) ENST00000495713 ENST00000489109 ENST00000491192

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANXA1

Additional cDNA sequence:

AB451274.1 AB451401.1 AK023330.1 AK074480.1 AK296808.1 AK311684.1 BC001275.1 BC018683.1

BC034157.1 BC035993.1 BT019896.1 BT019916.1 BT019917.1 CR407684.1 X05908.1

24/49 DOTS entries (see all 49):

DT.95080391 DT.100890399 DT.95202652 DT.100765659 DT.100890413 DT.100890422 DT.100890394 DT.100890395

DT.121161786 DT.100890415 DT.95340497 DT.95223581 DT.92045136 DT.92466092 DT.100040129 DT.100890410

DT.100890409 DT.91793108 DT.91703452 DT.91949347 DT.121161854 DT.100890404 DT.92466082 DT.92466099

1569 AceView cDNA sequences (see top 24):

BQ434247 CB132717 CB136230 CB110563 BM987259 BQ775882 AL702872 BG760604

CB134061 CA418081 BE885625 BM762806 BP368115 BU615234 BM970156 BU182629

CB161300 CB155823 CA441775 AI962890 AK074480 AU138337 BQ776007 BM981135

AA131864 CB122386 AW467211 CB147928 AU138129 AA715167 CB132818 CB132359

CB136035 BU628406 CB163374 BU521640 AU137801 CB108952 AI358733 BQ774960

BU508618 CA449230 CB131626 BU190167 BG010285 R31786 BQ773942 BF033907

BQ953713 CB150767 CR608313 BQ019437 BF195113 BQ694461 BU627677 CB132807

H29761 BM995855 BM842806 CB111060 BM846426 BM995408 CB135040 CA417462

CB135351 CB136212 N85304 BQ776002 BM850145 BG571041 CA422748 BM920866

AI332602 CA419928 CA441813 BQ775102 BM850142 AW117810 CA392316 CB113028

CB112993 BE890043 CB113217 CF130760 AL712296 AU138607 BU190139 CB112891

BE882507 CA437362 CA446942 CB127277 BM845550 BM842714 CB134078 AU137131

BM789211 BM991397 BQ021512 CB110454 BQ424962 W25534 CB125606 CD679498

CF131650 BU956940 CA442733 BU615416 BQ222672 BQ335437 CB134127 CB125959

CR608352 CB140863 BM842466 BM818339 BU506807 CD709026 CB135057 BE163625

BM556687 BC001275 BQ775374 CB141096 BE880201 AI147775 BX438944 BM757825

CB139268 CR599722 BG250516 CR598206 BU633206 CB139393 BM765134 BQ776306

AU137564 BM827188 CB134806 BQ940514 BQ776341 BQ774950 CB134840 BM760719

BP336523 AW169048 AL553114 BG678033 CA414702 BM986777 CR622273 BQ774641

BM760791 BM995441 AA010674 BM749560 BM826264 BP379651 BQ962446 BG679690

BU507296 BM803483 AI022506 BM995358 BQ946134 CB135706 BG231632 BM769981

CB136295 CA445329 CR407684 CA447733 BQ435367 CB159233 CA418232 BM846924

CB134670 BU195778 BE746626 AW514084 BQ962441 BQ962615 BM830896 CB112437

BM762676 BG573326 BF107275 BM458053 BG036076 CA418062 BU676462 CB136007

CA443862 CB136279 AA131951 BU684426 CB136463 AU139930 BQ005718 CB131879

BM842907 CR618229 CB123859 BM800254 BQ775919 CR610492 AA360576 BQ962052

CB134453 CA445734 BM476344 BE885940 AI798564 BQ959907 BU857810 CB132680

AW438572 AU077077 CB132841 BU683687 AL541874 CB134533 AI280711 CB135558

AA348569 CA434798 BM746101 BM995304 BM987115 BM712226 CF129666 AI672375

AI923018 BQ228510 CA419844 AU133942 BQ775850 BG287885 BG121662 BM989679

CB043933 BU737695 CB131848 BM842361 AW439690 BU627114 BG748968 AA348570

BQ775829 CB150973 BF448451 BM995828 CB149662 CB134143 CA419768 AL702862

AA302654 BX417009 BQ435432 BQ774780 CB409715 CB120109 CR602892 BU902570

CB136196 CB135546 CB135270 CB134067 CB116281 CF528215 BQ216979 BM853335

CN484542 BM782419 CB123295 BU187916 CA310269 BM968424 CB110876 BU615320

BQ774017 CA418210 BM972091 AA367410 CA447223 BM788150 CB147624 CD516650

CA417639 AU135495 BQ182544 CA434933 AU135571 BE669975 CB136247 AL544959

BM848122 BM760811 BM842373 CA419750 BG573931 AU137423 CB159445 BQ434324

CA405627 CB127865 CB306442 CA421424 CR600988 AU135762 AW572518 BQ776326

BM990412 BE395726 NM_000700 CB147659 AI150668 BI868606 CR592907 CB147922

BM740875 CB113203 AW072656 BI492456 AI357955 BM555842 CB113246 R07821

CB134160 CB134140 BU674526 CB147894 AU134300 BG118456 CB126936 BM762989

BM845260 BM550642 BQ004842 BM760731 AI631302 BQ775964 CB136301 CB138167

CB159741 BQ005728 CA444151 CB131932 BM786699 BM842678 CR607819 AI057004

CB138353 BQ776006 CF127699 AI678828 CB112370 CA429282 CB160508 CB124501

BQ017672 CB132713 BM461778 BI052409 BM850080 BQ775843 CB851093 BM849838

CB151251 AW238543 BU676623 BG680014 CA415613 BF218920 CB112977 CB127802

BM760779 CB139184 AU139656 CB120549 CB135025 CB109094 CB128492 BM996954

CB147648 BF981334 AA039810 CR626421 CB135009 BC035993 CB136288 BE889674

CB132658 CB134457 CB113708 AA159054 BM994528 AI087195 CB217021 AK023330

BG547036 BM842508 AU136839 BM758543 AI022270 BQ016213 W80525 CD687517

CB956365 CA440642 BM887966 AV757833 BM845532 W80526 BU681987 BM844210

BU173401 BU929760 AW473645 BM993633 BG562579 BM762707 BQ954100 AU136700

BU679642 CB043934 BM794647 BG677869 BM744729 AW029347 CD684477 BG620758

CB127311 CB955986 CB111403 AL551427 AI979080 AL541443 BP381696 BG573253

CB115529 BM759170 AA046308 AI039844 AW079763 BQ775183 BM847088 BU929743

CD691486 H39785 AI818672 BM771850 BF980639 CB267332 BU674368 AA039737

BM746981 BP370919 CF454990 CD102824 BG339459 BG779213 CB125827 BU902298

BM746402 BE889618 AL542692 AW262781 CB963002 BG620898 BM851325 BU521798

BG434661 AI270599 AL691612 BE019690 BM845717 CB137972 AW468040 AU139272

CB134621 CD677426 BG571271 AI094311 BG620689 AI670795 BQ962035 BU858319

BG121427 AL551980 BM477702 CA420206 AU122831 CB956944 AW239219 BU928797

CF146870 BG547240 AV734845 BE613877 BE883722 BU928528 AI338272 CB962188

BM752075 BM473319 BM983867 CA442311 BM750832 BP342993 BP374665 BM454970

BU929436 N78655 AI086736 BM744229 BM740085 CD250663 AI367059 CB121925

BG434791 BG250705 BF685893 W15144 T64980 BM762941 BG573210 BX501336

BG119474 BM746343 BM759959 CB111034 CB122107 BM462335 AL544231 CB125306

BG534570 CA449033 BM748919 BM760875 BI868345 AL553129 BE890028 BM743253

AU138813 AV756113 BG573430 BG117049 BM856193 AV717869 CD000909 BQ775387

BM760191 AI680227 CF127674 BU933687 CB135055 N33815 BM756474 AU137370

BG624029 BG622789 BM048854 CD357777 BU597064 BV204059 BM846695 BM739866

AI886488 BE613536 CB962764 BM982862 BX474299 BG572458 CA423056 BG435187

BU629961 AL574991 CD109243 BQ937881 BE620413 BM760219 BQ221472 H63077

BG573610 AL576603 BM739445 AI037945 CB131899 BC018683 BU752453 BQ940619

BI752394 BG621285 CB118653 CB136143 BM842987 AU135381 BM847083 BG620352

BG572320 AW664152 BM744204 BQ774630 BM995280 BE882050 BG434528 BM739365

AW513527 AI349473 CB108524 AI192129 BG252580 AI306452 BG571765 BG622925

CB138653 CB136396 AL575425 CB132696 BM758432 BG777275 BG111978 BG621352

BE890074 CD103971 BM764292 BG572031 AA099365 BF979239 BP375459 AA962646

BE889354 AU139496 BG434991 BG545788 BE888717 BG620214 BG436155 BU928693

CD721824 BG434942 BM756443 BG620532 BG679589 BE890010 BG620205 BG572153

BM842421 CF994973 BM745701 BG528322 CB143442 BG687581 BF149206 CA420770

BG621339 BG036592 BM739221 BM748929 CD684885 CB112716 AI299600 BG534763

CB150687 AA554877 BQ182979 AL570428 AW999255 BE886256 BU164446 CD000479

CB126294 BM789282 AU135525 AI986240 BX348416 BF149207 BQ775193 AW021498

CB131923 AW850843 AW339658 BM747889 BM847906 BQ721913 BC034157 N59590

CA415933 AL553679 BU930491 CA441709 BU688335 AW192618 CB125445 BU630013

W42857 CA419989 CD705361 CK823785 BM463582 BM843952 BX507122 BM843042

BG621477 AA327460 BQ718082 CD639416 BP352802 BG776752 BU789080 BG572467

CB853761 CB122017 CB136976 CD103569 BI256470 CB215652 BV204060 BM740289

BG496240 W76438 BU684376 BG620959 BG570750 CB115909 BU597585 CB125577

BQ962667 CA419301 BF980977 CB127544 CA417844 BU929502 CB112529 AI828147

AI031690 CD103473 BE613538 CB118454 BF972534 CB135462 CB267064 AI984755

BM760197 AL570884 BQ224201 AI147859 CD000474 BM510891 BU957173 CD110331

AU137127 BQ574852 CB132652 AA363572 CF595860 BF340792 BG164494 BM740228

AW467650 AI963054 CB122051 CB114461 BG620590 BQ775247 BF683998 BG572901

AI539640 BF980563 CB135418 BG434770 BE393571 BG778566 BU508007 BU928601

AW118316 BG681137 BM788544 BG250298 BU686652 BU674442 CB137328 BG619919

BU684047 BG622681 CB956847 BE869220 CD512646 BG687189 BG571121 BE888097

CB114390 BM758397 BU502272 AI085396 BM740086 AW129915 BF095450 CD558409

BU929078 BM754761 BQ774936 W42912 CA417944 BM747375 CA442302 BG620225

BP382355 CD103647 BG623205 BE883571 BF445884 BM743950 BG527308 BQ938524

BQ723044 AI066807 CB132820 CB113086 BM807190 BG681568 CB135074 BU180800

BQ776203 CB986517 CB132830 BG623808 AI499359 BG435452 AL553164 BE886273

BE889096 BG571516 BM738660 BM851366 CB963360 BE885684 AL540651 BF672419

BU958850 BF672909 CB151936 AA011261 AL576223 CB131859 BG116608 BM757785

AI561140 CB120356 CB126252 BU683999 CA445151 BU945187 CB135677 BQ719960

BG619843 BM739388 BG571562 BG620876 BG573502 BG571479 BM846445 AA948331

BG571367 CB124350 AV714294 BE160277 BQ929510 BG623830 BU928685 BQ776243

BU615206 BU928885 BG749612 CB044951 H29760 BM843422 BM754763 BM837257

BU627440 CF528314 CF596030 CD639441 BG624090 BM752353 BM751542 BM846290

BU178154 BU940658 CB151143 CD688191 AW057775 BU521988 BE787422 BG167328

BM845449 CB147954 N69948 AA046396 BG702992 BE163637 CA414418 BG678513

BG571090 BQ020469 W81113 BG679758 CA419446 AL576340 BM851617 BG623139

BF686527 BG337791 BG336968 BG527055 BM843593 BF245840 BM555529 BG623470

BM740144 W07418 CB111024 BM846751 BQ422205 BU600229 CD638542 AI955777

CB111030 BU508760 BG573501 BM460109 CA422051 BG571202 CB962367 BQ439412

BM920224 CF147180 BG534436 BU751757 BM754322 CB137469 BG435433 BU679283

BE160359 AI573175 BU173056 BG573340 BM468858 CD109767 CA419688 BM747733

CB998740 BE884472 BM462354 AI749676 AU135221 BM740883 BM968595 BG570715

BM788031 AI538710 BM839488 AU117349 CB111629 CD107895 BM803761 BE614257

BU198784 CB994837 CD103625 AA101915 CB108957 AA581405 AI932795 BF973004

BG619250 BM888427 CB044522 CB145999 CB124638 BG681724 BM747337 BM836033

BG623682 BP366479 CA449271 CB129393 BE786030 AI719290 BX344057 BQ183243

CB124594 BE784318 BU838395 BM842271 BG434802 BG435471 BM851619 BF037244

BG571454 CD104334 BG622424 BQ775650 BU630502 CB111404 CB321626 BG623793

AI280717 BM838687 CD242178 BU928345 CB127414 CB111615 BU521785 AL079950

AI818697 BQ225644 BG779520 BM847961 CB120815 R79111 CB119610 BE789424

BQ228162 BE889391 BG436236 BE886383 BG750453 BF218446 CB116745 AU138502

CA419718 BG573351 W84575 BM745645 N51341 BU929725 AA129310 BU596129

BM760977 BG573677 D20825 BG943816 AI682729 BG435105 BM756535 CA414442

BM819669 BE889657 N24938 BQ694023 BU752523 BM747414 BE139643 AA159055

BF245291 CD697017 BF215528 BU940400 AI023174 AI811218 BF672562 D58885

BE777467 AI764962 BF790680 BE789848 CB854645 AA166969 BM739198 BU509156

CB045799 AI682611 BM838991 AA932100 BM845285 CD695322 BG899264 BG540978

BG687509 BG340446 BM750521 BE315143 AA346298 AI266490 BI085829 BQ775612

C18232 CD299790 AW337908 BE738188 CB126846 CD695323 CF146869 BE720604

CD687235 BQ019474 CD703594 AI279070 H63161 BM739318 AV733665 BF088984

AI338043 CB998055 CB270261 AL603330 AI540773 CD638732 CD702358 BU506634

BF107108 AW366462 AV756671 W19292 BP383615 AW366472 BG253756 BF696507

AL601158 AV761675 BF243458 BG435073 BF107418 BE933725 BM759488 N81077

AA040524 BM739930 AA903464 BG435268 AU156892 BE720764 CB136074 BF038449

BM740013 BF107233 CD357534 CB124198 AW238266 AA040523 BP382579 CB987639

BP352484 BM748957 AW022429 BU570993 BM843659 AA129354 BM844197 AA885878

H98885 BM828795 BG572361 AA319694 BM739854 BM842587 CB957903 BG619561

BF244163 AA975685 BU632561 BE738025 W48727 BF673438 BF029110 BG255938

BX365112 CB106901 AL541873 AW275945 BG766411 BF971769 BG776062 BG538873

BM511137 BG435508 BF671133 CA419564 BF219314 BG899315 BG619228 BE883891

BP351463 AI624277 H98992 CB119021 BU628720 BU789342 N62387 CB997886

BP335322 CD706274 BG619381 CA418335 CD514880 AI337825 CB958575 BM844811

AU157482 BM754252 BG622060 CF541379 BM822987 BF696793 BG620595 N67836

BE163643 AL709482 BG398702 BG287303 CB113742 AI826887 BE858148 CB136115

W37911 AW265418 BG624009 AW804129 BU508540 BG290890 BG539465 CB961976

AI687462 BE620646 BE785202 N51352 CD700733 BM848473 BG007942 AI361977

CD688118 AA449864 AU156107 BM888285 BE160289 CB117763 AA026981 BQ335285

CD684049 AI570887 CD699329 AW950757 AI865855 AV763314 BM846654 BF088979

AA852087 BE925544 CD699670 CD690005 CD702736 BI012577 BE712360 AU156143

CD250376 CD699759 AI540583 BF905554 CB409714 BM739299 AV748590 CD690810

W84645 CD687060 BG900706 BF698764 BG896171 AL553095 AV757230 CD684470

AW591195 CD689301 N47897 N47174 BE874337 BE925543 CD703196 CD702693

CD000719 BX397194 CD692581 BG434635 CD103285 CD694381 CD690837 AU155902

CD689254 AW361177 BG573239 R70896 CD706936 BU680229 BG623705 BF031223

BE160371 N98329 AU122830 CD698703 BG435737 BE185259 BE147909 CD109274

BF130804 CB151366 BQ278422 H67182 AI129114 BQ774022 CD693933 W01767

BE711116 BF242795 AL569557 BF107498 BU688602 AV747314 BF573009 BE176399

CB116217 AW862567 CA407565 CB159497 CD700391 R70897 CD688703 BG928764

AV716730 CD691742 AI721155 BQ336043 BE439455 CD707727 BU929127 CB136066

CD686862 BE567857 BG538819 CD703906 BG924221 BM751595 AU158118 CD697943

BU752675 BF217410 CD686637 BX480257 BF246106 CB121918 AL568911 BE004257

BE885645 BF700315 BE161231 AW366471 BM844678 BG620117 BF685662 CD686458

AA583722 BU752360 BG494471 CD685271 BF326986 AU100582 W03440 BF750549

AA846272 BG436005 BE172402 CD707908 BE784321 BE567062 BM751077 CD704955

AI073585 BF214785 BM171959 R68218 AW960307 BM740242 BF243102 BE546162

AL703125 CD692816 AW800507 BU198917 AW496835 CD356781 R95461 BF904444

BM850367 AW366467 BE720571 BE383656 AW366525 CD299514 R31078 BG537207

BM845557 AI446311 BG008406 N94343 CD706490 AV714843 BF921635 BF154724

BE865476 BG529687 BU509361 BG623652 BF735988 AI682127 BG184369 BU945485

BF904437 BI085188 BG541130 BE932977 BF989835 BE566362 BF665298 BF905537

AU144202 BG993544 BE565189 BF242088 BE884608 BQ427863 CD103464 BI052224

BF735916 R74083 AI758653 BF245980 AU155094 BF107150 AA357057 AA095650

CD102626 BE932349 BE932321 R79110 N53997 BQ331329 BM146900 BE719992

H75713 BG545900 BF369720 AI949487 AI282740 BG927740 W72791 AI582574

BM855347 BE567581 W48630 BF475353 BG999470 CD242053 AV756589 AA344036

BF218154 BE171873 CB993260 AU157321 CD357335 N79355 BF089413 AW368553

CB125460 H26949 BG007934 BE169685 BG118490 BF245668 BG030819 AW379821

AV755997 BG571093 AW273023 AV716650 AI023056 CD298759 AW366477 AV756534

CB986145 AI587504 BQ027046 BM955812 AI567775 CD522452 BE163913 AI302921

BF245428 AA095823 AI818691 BE886263 BE172555 R76864 AA031662 BG572789

AA927497 CB999774 BG573821 BE547632 BM462609 BQ366085 BF243032 CD356648

BF736086 CF126160 H67860 AV713049 BG250812 BF986460 H95014 CD110544

T50599 AI708665 BF692781 AV757969 AW606762 AL573446 AA737109 R74084

AW262752 H01087 BF154713 AW842233 W80546 AW960301 T50464 BE172191

AI269234 BQ379073 BF985295 BE708485 BF351532 BF369722 BF832806 BU506953

BE169826 AW379698 BF028253 BE711979 BF089377 BG570818 CD702271 BF900810

BE171982 BF369745 BM809820 BU162389 BM802205 BF217501 BQ329288 BF747975

BM453043 R25615 N63017 AA186409 R75849 BG165824 R68513 BF241022

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15a	·	15b
SP1:					-		-		-		-		-						-				-						-										-						-
SP2:																			-				-						-										-						-
SP3:					-				-		-		-						-				-						-										-
SP4:																													-										-
SP5:							-		-		-		-						-				-						-

ECgene alternative splicing isoforms for ANXA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANXA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAAGATGT

About this image

ANXA1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cells

Cardiac Fibroblasts

Positive expression

Microarrays (high-throughput)

Epicardium

Cells

Positive expression

Microarrays (high-throughput)

Kidney

Cells

Mesenchymal Condensate Cells

Positive expression

Microarrays (high-throughput)

Bone, Cartilage

Anatomical compartment

Visceral White Adipose

Positive expression

Microarrays (high-throughput)

Adipose

Anatomical compartment

Medulla Oblongata

Positive expression

In-situ hybridization

Brain

Anatomical compartment

Renal Collecting Duct System

Positive expression

Microarrays (high-throughput)

Kidney

Anatomical compartment

Positive expression

In-situ hybridization

Lung

Expression:

Positive

Negative

cell-identifying gene

Selective marker

Experimental details:

Curated

High-throughput

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

Cultured cells

CyT49 (Embryonic Stem Cell)

Positive expression

Microarrays (high-throughput)

Early Embryo, Inner Cell Mass

Cultured cells

Line H9 (WA09) (Embryonic Stem Cell)

Positive expression

Microarrays (high-throughput)

Early Embryo, Inner Cell Mass

Protocol derived cells

Dorsal forebrain-like neurons (Generation of midbra...)

Positive expression

Microarrays (high-throughput)

Brain

Protocol derived cells

N2/LSB induced-cells (Generation of midbra...)

Positive expression

Microarrays (high-throughput)

Protocol derived cells

Syncytiotrophoblast-like cells (Generation of syncyt...)

Positive expression

Microarrays (high-throughput)

See ANXA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANXA1

SOURCE GeneReport for Unigene cluster: Hs.494173

SABiosciences Expression via Pathway-Focused PCR Array including ANXA1:

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANXA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ANXA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANXA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANXA1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANXA1 gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ANXA1¹	annexin A1	75.07(n) 78.59(a)		404271 NM_206906.1 NP_996789.1
lizard (Anolis carolinensis)	Reptilia	ANXA1⁶	--	76(a)	1 ↔ 1	2(47805415-47820443)
African clawed frog (Xenopus laevis)	Amphibia	anxa1-prov²	annexin A1	77.96(n)		BC053786.1
zebrafish (Danio rerio)	Actinopterygii	anxa1a²	annexin A1a	73.36(n)		334724 AY178793.1
fruit fly (Drosophila melanogaster)	Insecta	AnnIX³	actin binding	45(a)		93B10 --
worm (Caenorhabditis elegans)	Secernentea	nex-2³	Annexin	42(a) (best of 3)		III(10397630-10399688) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ANNAT2⁶ ANNAT5⁶ (see all 8)	annexin D5 (see all 8)	33(a) 32(a) (see all 8)	many ↔ many many ↔ many (see all 8)	5(25973815-25975726) 1(25519442-25520774)
rice (Oryza sativa)	Liliopsida	-- -- (see all 9)	annexin, putative, expressed (see all 9)	36(a) 32(a) (see all 9)	many ↔ many many ↔ many (see all 9)	9(13705487-13710510) 8(20456985-20458908)

ENSEMBL Gene Tree for ANXA1 (if available)
TreeFam Gene Tree for ANXA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANXA1 gene

ANXA3² ANXA6² ANXA5² ANXA9² ANXA2² ANXA7² ANXA8² ANXA11²

ANXA8L2² ANXA10² ANXA8L1² ANXA4² ANXA13²

15 SIMAP similar genes for ANXA1 using alignment to 6 protein entries: ANXA1_HUMAN (see all proteins):

ANXA2 ANXA2P2 DKFZp686H02120 ANXA13 ANXA7 ANXA8

ANXA11 ANXA3 ANXA4 ANXA5 ANXA8L2 ANXA6

ANXA8L1 ANXA9 ANXA10

ANXA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112765295^1,2	C,F,	--	75764783(+)	`TAGTGG/ACTTTC`	1	--	us2k¹		1		NA	120
rs2310312^1,2	C,F,O,A,H,	--	75764998(+)	`CAAAGC/AAAAAT`	1	--	us2k¹		24		NA NS EA WA	2694
rs139090859^1,2		--	75765039(+)	`TTTTAC/TAAAAA`	1	--	us2k¹		0	--	--	--	--
rs142395928^1,2		--	75765093(+)	`AGGAAA/TGTTCC`	1	--	us2k¹		0	--	--	--	--
rs3758355^1,2	C,H,	--	75765100(+)	`TTCCAA/GTAGTT`	1	--	us2k¹		5		EA NS	1898
rs192915422^1,2		--	75765212(+)	`TATTAA/GAAAGT`	1	--	us2k¹		0	--	--	--	--
rs78590593^1,2	C,	--	75765229(+)	`ACATCT/CGTCAA`	1	--	us2k¹		3		CSA WA	121
rs185181036^1,2		--	75765234(+)	`TGTCAA/GGATCA`	1	--	us2k¹		0	--	--	--	--
rs33942988^1,2	C,	--	75765264(+)	`ACTTA-/ACTTGT`	1	--	us2k¹		0	--	--	--	--
rs117038162^1,2	F,	--	75765351(+)	`GATTAG/CATGAT`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for ANXA1 (75766673 - 75785309 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ANXA1
1 CNV: 52859

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANXA1

DNA2.0 Custom Variant and Variant Library Synthesis for ANXA1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANXA1 for disorders           About GeneDecksing

OMIM gene information: 151690    OMIM disorders: --

20/74 diseases for ANXA1 (see all 74):    About MalaCards

b-cell non-hodgkin lymphoma non-hodgkin lymphoma squamous cell carcinoma uterine fibroid

brain edema hodgkin's lymphoma idiopathic pulmonary fibrosis laryngeal squamous cell carcinoma

hairy cell leukemia oral squamous cell carcinoma esophageal squamous cell carcinoma cystic fibrosis

pulmonary fibrosis inflammatory bowel disease sarcoidosis transitional cell carcinoma

psoriatic arthritis rheumatoid arthritis pulmonary sarcoidosis muscular dystrophy

1 disease from the University of Copenhagen DISEASES database for ANXA1:

10/52 Novoseek disease relationships for ANXA1 gene (see all 52) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell	41.2	25	15447985 (3), 12242662 (2), 18297688 (2), 12679902 (2) (see all 17)
adenocarcinoma lung	38.7	5	17351649 (2), 17974280 (1)
inflammation	32.3	33	9796991 (3), 15962097 (3), 19104500 (2), 9831319 (1) (see all 21)
premalignant	27	6	10448305 (1), 19351789 (1), 19101730 (1), 14695321 (1)
tumors	24.8	58	16270603 (4), 19173988 (3), 17340616 (3), 18652761 (3) (see all 29)
prostatic intraepithelial neoplasia	23.9	4	16324197 (2), 11801547 (1)
colon adenocarcinoma	23.9	6	15526283 (3), 18541673 (2)
oral cancer	21.1	6	18297688 (2), 20371204 (1), 12870656 (1)
cancer	16.7	34	18663355 (4), 20215502 (2), 16324197 (2), 20371204 (1) (see all 15)
metastasis	16.6	22	18535914 (3), 20353277 (3), 18776816 (3), 18223218 (2) (see all 11)

Genetic Association Database (GAD): ANXA1
Human Genome Epidemiology (HuGE) Navigator: ANXA1 (6 documents)

Export disorders for ANXA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ANXA1 gene, integrated from 9 sources (see all 516):
(articles sorted by number of sources associating them with ANXA1)

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Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PubMed id 2936963)^{1, 2, 3} Wallner B.P.... Pepinsky R.B. (1986)
Crystal structure of human annexin I at 2.5-A resolution. (PubMed id 8453382)^{1, 2, 9} Weng X.... Huber R. (1993)
Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PubMed id 16883066)^{1, 7, 9} Morand E.F....Yang Y.H. (2006)
Phosphorylation of annexin I by TRPM7 channel-kinase. (PubMed id 15485879)^{1, 2} Dorovkov M.V. and Ryazanov A.G. (2004)
[Absence of evidence for the association of single nucleotide polymorphisms in Annexin A1 gene with type 2 diabetes in Chinese] (PubMed id 15476183)^{1, 4} Dong Y....Luo M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of the annexin I gene and evaluation of its role in type 2 diabetes. (PubMed id 11574426)^{1, 4} Lindgren C.M....Groop L.C. (2001)
NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit. (PubMed id 9915835)^{1, 2} Gao J.... Yan H. (1999)
Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. (PubMed id 8425544)^{1, 2} Arcone R.... Ciliberto G. (1993)
Correlation of gene and protein structure of rat and human lipocortin I. (PubMed id 1832554)^{1, 2} Kovacic R.T.... Wallner B.P. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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			AND	OR
	Aliases
	Disorders
	Free Text

	Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 301	HGNC: 533	AceView: ANXA1	Ensembl:ENSG00000135046	euGenes: HUgn301
ECgene: ANXA1	H-InvDB: ANXA1

(According to HUGE)
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--

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ANXA1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ANXA1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ANXA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ANXA1 gene:
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