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ANXA1 Gene

protein-coding   GIFtS: 71
GCID: GC09P075766

Annexin A1


(Previous symbols: ANX1, LPC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Annexin A11 2     annexin-12
LPC11 2 3 5     calpactin-22
ANX11 2 3     chromobindin-92
Calpactin II2 3     Annexin-13
Lipocortin I2 3     Calpactin-23
Phospholipase A2 Inhibitory Protein2 3     Chromobindin-93
p352 3     Annexin I3
Annexin I (Lipocortin I)2     

External Ids:    HGNC: 5331   Entrez Gene: 3012   Ensembl: ENSG000001350467   OMIM: 1516905   UniProtKB: P040833   

Export aliases for ANXA1 gene to outside databases

Previous GC identifers: GC09P066811 GC09P067623 GC09P069336 GC09P071223 GC09P072996 GC09P074956 GC09P045589


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANXA1 Gene:
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of
approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane.
Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity.
Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins
and leukotrienes, annexin I may have potential anti-inflammatory activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for ANXA1 Gene:
ANXA1 (annexin A1) is a protein-coding gene. Diseases associated with ANXA1 include brain edema, and colon adenocarcinoma. GO annotations related to this gene include phospholipid binding and calcium ion binding. An important paralog of this gene is ANXA3.

UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

Gene Wiki entry for ANXA1 (Annexin A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANXA1 gene promoter:
         C/EBPbeta   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   AREB6   POU2F1   POU2F1a   STAT3   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ANXA1 promoter sequence
   Search Chromatin IP Primers for ANXA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANXA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q21.13

ANXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P075766:  view genomic region     (about GC identifiers)

Start:
75,766,673 bp from pter      End:
75,785,309 bp from pter
Size:
18,637 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083 (See protein sequence)
Recommended Name: Annexin A1  
Size: 346 amino acids; 38714 Da
Subunit: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity)
3 PDB 3D structures from and Proteopedia for ANXA1:
1AIN (3D)        1BO9 (3D)        1QLS (3D)    

Explore the universe of human proteins at neXtProt for ANXA1: NX_P04083

Explore proteomics data for ANXA1 at MOPED

Post-translational modifications: 

  • Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in
    loss of the inhibitory activity1
  • Ubiquitination2 at Lys58, Lys166, Lys274
  • Glycosylation2 at Ser37
  • Modification sites at PhosphoSitePlus

  • See ANXA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000691.1  
    ENSEMBL proteins: 
     ENSP00000257497   ENSP00000412489   ENSP00000414013   ENSP00000366109  
    Reactome Protein details: P04083

    ANXA1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ANXA1
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    Novus Biologicals ANXA1 Proteins
    Novus Biologicals ANXA1 Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ANXA1
    Cloud-Clone Corp. Proteins for ANXA1

    ANXA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANXA1
    R&D Systems Antibodies for ANXA1 (Annexin A1)
    Cell Signaling Technology (CST) Antibodies for ANXA1 
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    ANXA1 Assay Products:

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    Cloud-Clone Corp. ELISAs for ANXA1
    Cloud-Clone Corp. CLIAs for ANXA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    ANXA: Annexins

    4 InterPro protein domains:
     IPR018502 Annexin_repeat
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS
     IPR002388 AnnexinI

    Graphical View of Domain Structure for InterPro Entry P04083

    ProtoNet protein and cluster: P04083

    2 Blocks protein domains:
    IPB001464 Annexin
    IPB002388 Annexin type I signature


    UniProtKB/Swiss-Prot: ANXA1_HUMAN, P04083
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    ANXA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANXA1_HUMAN, P04083
    Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This
    protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity

         Genatlas biochemistry entry for ANXA1:
    annexin A1,calcium and phospholipid binding protein,calpactin 2 (calelectrin),expressed in the supporting cells of
    the organ of Corti,located in the DFNB7 interval,involved in the regulation of early delayed glucocorticoid
    feadback action in the hypothalamo-hypophysial system

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity ----
    GO:0005102receptor binding TAS10882119
    GO:0005198structural molecule activity IDA10908733
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
         
    ANXA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ANXA1:
     Decreased viability 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Anxa1):
     adipose tissue  cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     nervous system  skeleton  tumorigenesis 

    ANXA1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANXA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANXA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANXA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANXA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANXA1:
    hsa-mir-30a-5p (MIRT028650), hsa-mir-335-5p (MIRT018638), hsa-mir-26b-5p (MIRT030065), hsa-mir-196a-5p (MIRT000709)

    Block miRNA regulation of human, mouse, rat ANXA1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ANXA1
    SwitchGear 3'UTR luciferase reporter plasmidANXA1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ANXA1

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    GenScript: all cDNA clones in your preferred vector: ANXA1 (NM_000700)
    Sino Biological Human cDNA Clone for ANXA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANXA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANXA1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANXA1_HUMAN, P04083: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity).
    Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of
    ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and
    alveolar macrophages (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular5
    cytosol4
    plasma membrane4
    endosome2
    mitochondrion2
    nucleus2
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001533cornified envelope IDA10908733
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS16130169

    ANXA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANXA1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Formyl peptide receptors bind formyl peptides and many other ligands0.00
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Spinal Cord Injury
    Spinal Cord Injury
    5Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ANXA1
        Ca, cAMP and Lipid Signaling

    4 BioSystems Pathways for ANXA1
        Integrated Breast Cancer Pathway
    Spinal Cord Injury
    Prostaglandin Synthesis and Regulation
    Integrated Pancreatic Cancer Pathway


    3 Reactome Pathways for ANXA1
        Formyl peptide receptors bind formyl peptides and many other ligands
    G alpha (q) signalling events
    G alpha (i) signalling events



    ANXA1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ANXA1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANXA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANXA1 (P040831, 2, 3 ENSP000002574974) via UniProtKB, MINT, STRING, and/or I2D (see all 310)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBB1O002132, 3, ENSP000002994024MINT-8247707 I2D: score=2 STRING: ENSP00000299402
    ENSG00000272333Q9UMN62, 3MINT-8247832 I2D: score=2 
    KMT2BQ9UMN62, 3MINT-8247832 I2D: score=2 
    C14orf1Q9UKR52, 3MINT-8247720 I2D: score=2 
    CCT7Q998322, 3MINT-8247753 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001780neutrophil homeostasis IMP--
    GO:0002674negative regulation of acute inflammatory response IEA--
    GO:0006928cellular component movement TAS10882119
    GO:0006954inflammatory response TAS10882119
    GO:0007049cell cycle ----

    ANXA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ANXA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ThiolutinBacterial RNA polymerase inhibitor[87-11-6]
    Heparin sodium saltAnticoagulant[9041-08-1]
    Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor[154303-05-6]
    RGDS peptideIntegrin binding sequence; inhibits integrin receptor function[91037-65-9]
    Ac2-26Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation[151988-33-9]

    1 HMDB Compound for ANXA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for ANXA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Hydrocortisone11beta-Hydroxycortisone (see all 16)50-23-7targetagonist1712816 17139284 11142771 17016423 8060156
    DexamethasoneDesametasone (see all 9)50-02-2targetagonist17644190 17076770 17158208 16883066
    Amcinonide-- 51022-69-6targetagonist17139284 17016423 7981624

    Selected Novoseek inferred chemical compound relationships for ANXA1 gene (see all 56)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hdmnkvldl 84.9 2 8818992 (1), 1793057 (1)
    phosphatidylserine 62.1 29 8179621 (3), 7627125 (1), 12744815 (1), 15381697 (1) (see all 16)
    phospholipid 59.7 33 8379935 (7), 2138536 (1), 1310621 (1), 8485141 (1) (see all 20)
    calcium 55 126 11142771 (6), 9299392 (5), 18283055 (4), 1469069 (3) (see all 58)
    arachidonic acid 49.2 16 2064175 (2), 8260938 (2), 2137129 (2), 12845669 (1) (see all 10)
    dexamethasone 45.3 54 8256657 (6), 12236584 (5), 17644190 (4), 14668092 (3) (see all 17)
    glyceraldehyde 3-phosphate 44.7 7 16220529 (1), 17268060 (1), 15274135 (1), 19899082 (1) (see all 7)
    geneticin 32.2 1 7764687 (1)
    phosphatidylcholine 30.4 17 16307464 (2), 12845669 (1), 7654693 (1), 1387325 (1) (see all 5)
    p-opc 30 7 16307464 (3), 18237543 (2)



    ANXA1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANXA1 gene: 
    NM_000700.1  

    Unigene Cluster for ANXA1:

    Annexin A1
    Hs.494173  [show with all ESTs]
    Unigene Representative Sequence: AK074480
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257497(uc004ajf.1) ENST00000468639 ENST00000456643 ENST00000415424
    ENST00000376911(uc004ajg.1) ENST00000495713 ENST00000489109 ENST00000491192

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      QuantiTect SYBR Green Assays in human, mouse, rat ANXA1
      QuantiFast Probe-based Assays in human, mouse, rat ANXA1

    Additional mRNA sequence: 

    AB451274.1 AB451401.1 AK023330.1 AK074480.1 AK296808.1 AK311684.1 BC001275.1 BC018683.1 
    BC034157.1 BC035993.1 BT019896.1 BT019916.1 BT019917.1 CR407684.1 X05908.1 

    Selected DOTS entries (see all 49):

    DT.95080391  DT.100890399  DT.95202652  DT.100765659  DT.100890413  DT.100890422  DT.100890394  DT.100890395 
    DT.121161786  DT.100890415  DT.95340497  DT.95223581  DT.92045136  DT.92466092  DT.100040129  DT.100890410 
    DT.100890409  DT.91793108  DT.91703452  DT.91949347  DT.121161854  DT.100890404  DT.92466082  DT.92466099 

    1569 AceView cDNA sequences (see top 24):

    CD709026 BG748968 CA419768 CA414702 CB159233 CB134078 CB409715 AW439690 
    CB147659 BM762676 BQ228510 BE163625 AA360576 CB134806 AU137564 BQ962052 
    BQ775829 CA405627 BQ962446 CA443862 AU137423 AU135495 BM476344 BU684426 
    AL544959 CR602892 BE880201 BE669975 BM995304 AL702862 CB120109 BX438944 
    BC001275 CA445329 BM788150 CB147624 CB127865 CB132680 AW117810 BM842373 
    AW572518 CB043933 CA417639 BM760719 CA434933 CA421424 CB306442 CB116281 
    BM746101 BG573931 BM782419 AA367410 BM995441 BU902570 CR618229 CB136007 
    BM848122 CF528215 BG121662 CA418210 CB110876 BU615320 AU135762 BM760811 
    CB135546 CB125959 CB159445 CA419750 CR600988 CB127277 BQ962615 CA447223 
    BM995358 CA310269 CB113217 BU187916 CN484542 CB135270 AU135571 CB131879 
    BM968424 BF448451 BM990412 BE395726 BQ774017 BM818339 CB136247 BU507296 
    BQ776326 CB134067 BG679690 BQ182544 BQ216979 CB134670 CB123859 BM853335 
    CA447733 BM986777 CB136196 BM826264 BE882507 BE890043 AL553114 BM995828 
    CB112891 CB134127 CB135040 AI672375 BU737695 CA419844 CR608352 BM556687 
    BM757825 AI798564 BQ775374 BM842466 BQ774641 BU633206 CB136279 BM458053 
    NM_000700 BM842907 AA348570 CA417462 BU190139 AI280711 BQ776002 BM991397 
    CB113028 AI332602 CA419928 BM845550 BM789211 BG571041 W25534 BM995855 
    BQ424962 AU138607 CA392316 CF130760 CA422748 CA441813 N85304 CA446942 
    CB125606 BM846426 BM850142 BM920866 CB147922 CR592907 BI868606 AI150668 
    BU956940 BM769981 BQ774780 CF131650 CR610492 AW438572 BM846924 AA302654 
    BM842361 CB136295 AW514084 BQ776306 CR622273 BM972091 BG573326 BQ335437 
    BM987115 CB139393 CB149662 BM800254 AI923018 BP336523 BQ962441 BQ940514 
    BU615416 CB134533 CA434798 AU137131 BU857810 BU190167 CB135558 CD679498 
    BM850145 CB135706 AU133942 CA418062 BU506807 BQ775919 BP379651 BX417009 
    BE885940 CR599722 BE746626 CF129666 BM842714 CA445734 BM760791 CB150973 
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    AI573175 CD109767 BM468858 BG573340 CA419688 BM747733 BE884472 BM740883 
    CB998740 BM462354 AI749676 BG570715 AU135221 BM968595 BM788031 AI538710 
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    BG779520 CB120815 BM847961 BQ228162 R79111 CB119610 BE789424 BE889391 
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    W84575 BM745645 BM760977 BU596129 BU929725 N51341 BG573677 AA129310 
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    AL542692 BU679642 BM794647 BQ954100 CB956365 CA440642 AL551980 AW029347 
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    AA346298 H63161 BU570993 BM739930 AL601158 W19292 BG572361 CB270261 
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    BP382579 BF107108 AI624277 AA319694 BG435508 BM844197 BM739854 CD687235 
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    BQ775612 AA932100 BM750521 BM748957 N62387 BP335322 CB997886 CD706274 
    CA418335 BG619381 CD514880 AI337825 CB958575 BM844811 AU157482 BM754252 
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    BG008406 CD356781 BM845557 N94343 BG537207 AW366525 CD707908 BE865476 
    BE383656 AW366467 BF154724 BE546162 AI682127 BF243102 BF905537 AU144202 
    BG993544 BE565189 BF242088 BE884608 BQ427863 CD103464 BI052224 BF735916 
    AV714843 BF750549 AU100582 CD685271 BF326986 BE172402 AA846272 W03440 
    BG436005 W72791 BQ331329 BF218154 BE171873 BG545900 AA344036 BE567581 
    BM855347 BF369720 AI949487 BE719992 AV756589 BE932321 CD102626 R79110 
    N53997 AU157321 W48630 BM146900 BG927740 BE932349 CB993260 BG999470 
    CD242053 AI582574 AI282740 H75713 BF475353 CD357335 N79355 BF089413 
    AW368553 H26949 CB125460 AA357057 AA095650 AI758653 AU155094 BF245980 
    R74083 BF107150 BM462609 H67860 AV713049 CB999774 BG573821 BG572789 
    AI302921 CD356648 CF126160 BF243032 BQ366085 BG250812 BF986460 BF736086 
    BE163913 CD298759 AI023056 AA927497 AV755997 AA095823 CD522452 BE886263 
    AV756534 AV716650 CB986145 AI587504 AI567775 R76864 AI818691 AW366477 
    BM955812 AW273023 BF245428 BQ027046 BE172555 BE547632 AA031662 BG571093 
    H95014 CD110544 T50599 AI708665 BF692781 AV757969 AW606762 AL573446 
    AA737109 R74084 AW262752 H01087 BF245668 BG007934 BG118490 BE169685 
    AW379821 BG030819 BE169826 BF832806 BE708485 BU506953 AW379698 AI269234 
    BE172191 BF351532 BF369722 T50464 BQ379073 BF028253 BE711979 BF089377 
    BF985295 AW960301 BF154713 AW842233 W80546 BU162389 AA186409 BG165824 
    BM802205 R68513 R75849 BM453043 N63017 BM809820 BF369745 BF747975 
    BF241022 BE171982 R25615 BF217501 BQ329288 BF985267 CD702271 BG570818 
    BF900810 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANXA1 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:              -     -     -     -     -                 -           -                 -                             -                 -                     
    SP2:                                                        -           -                 -                             -                 -                     
    SP3:              -           -     -     -                 -           -                 -                             -                                       
    SP4:                                                                                      -                             -                                       
    SP5:                    -     -     -     -                 -           -                 -                                                                     


    ECgene alternative splicing isoforms for ANXA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ANXA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAAGATGT
    ANXA1 Expression
    About this image


    ANXA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 34) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             Line H9 (Naive)
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Cerebral Cortex
             Dorsal forebrain-like neurons
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Laryngeal Cartilage
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocytes Zeugopod Epiphyseal End
             Bone Marrow
    ANXA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANXA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.494173
        Pathway & Disease-focused RT2 Profiler PCR Array including ANXA1: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ANXA1
    OriGene qSTAR qPCR primer pairs in human, mouse for ANXA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANXA1
    QuantiTect SYBR Green Assays in human, mouse, rat ANXA1
    QuantiFast Probe-based Assays in human, mouse, rat ANXA1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANXA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANXA1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anxa11 , 5 annexin A11, 5 86.61(n)1
    87.57(a)1
      19 (13.83 cM)5
    169521  NM_010730.21  NP_034860.21 
     203734285 
    chicken
    (Gallus gallus)
    Aves ANXA11 annexin A1 75.07(n)
    78.59(a)
      404271  NM_206906.1  NP_996789.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANXA16
    annexin A1
    76(a)
    1 ↔ 1
    2(47804835-47822960)
    African clawed frog
    (Xenopus laevis)
    Amphibia anxa1-prov2 annexin A1 77.96(n)    BC053786.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anxa1a2 annexin A1a 73.36(n)   334724  AY178793.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nex-23 Annexin 42(a)
    (best of 3)
      III(10397630-10399688)   --


    ENSEMBL Gene Tree for ANXA1 (if available)
    TreeFam Gene Tree for ANXA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANXA1 gene
    ANXA32  ANXA62  ANXA52  ANXA92  ANXA22  ANXA72  ANXA82  ANXA112  
    ANXA8L22  ANXA102  ANXA8L12  ANXA42  ANXA132  
    15 SIMAP similar genes for ANXA1 using alignment to 6 protein entries:     ANXA1_HUMAN (see all proteins):
    ANXA2    ANXA2P2    DKFZp686H02120    ANXA13    ANXA7    ANXA8
    ANXA11    ANXA3    ANXA4    ANXA5    ANXA8L2    ANXA6
    ANXA8L1    ANXA9    ANXA10

    ANXA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANXA1 (see all 449)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127652951,2
    C,F--75764783(+) TAGTGG/ACTTTC 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs23103121,2
    C,F,O,A,H--75764998(+) CAAAGC/AAAAAT 1 -- us2k124Minor allele frequency- A:0.19NA NS EA WA 2694
    rs1390908591,2
    --75765039(+) TTTTAC/TAAAAA 1 -- us2k10--------
    rs1423959281,2
    --75765093(+) AGGAAA/TGTTCC 1 -- us2k10--------
    rs37583551,2
    C,F,H--75765100(+) TTCCAA/GTAGTT 1 -- us2k15Minor allele frequency- G:0.02EA NS 1898
    rs1929154221,2
    --75765212(+) TATTAA/GAAAGT 1 -- us2k10--------
    rs785905931,2
    C--75765229(+) ACATCT/CGTCAA 1 -- us2k13Minor allele frequency- C:0.08CSA WA 121
    rs1851810361,2
    --75765234(+) TGTCAA/GGATCA 1 -- us2k10--------
    rs339429881,2
    C--75765264(+) ACTTA-/ACTTGT 1 -- us2k10--------
    rs1170381621,2
    F--75765351(+) GATTAG/CATGAT 1 -- us2k11Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for ANXA1 (75766673 - 75785309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ANXA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6561CNV Insertion18451855
    nsv526225CNV Gain19592680
    nsv519796CNV Gain19592680
    nsv893452CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151690    OMIM disorders: --

    Selected diseases for ANXA1 (see all 75):    
    About MalaCards
    brain edema    colon adenocarcinoma    oral cancer    uterine fibroid
    prostate adenocarcinoma    hairy cell leukemia    sarcoidosis    pulmonary sarcoidosis
    lung adenocarcinoma    psoriatic arthritis    stomach cancer    oral squamous cell carcinoma
    endocarditis    idiopathic pulmonary fibrosis    laryngeal squamous cell carcinoma    cystic fibrosis
    esophageal squamous cell carcinoma    pulmonary fibrosis    adenocarcinoma    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for ANXA1:
    Carcinoma

    ANXA1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ANXA1 gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 41.2 25 15447985 (3), 12242662 (2), 18297688 (2), 12679902 (2) (see all 17)
    adenocarcinoma lung 38.7 5 17351649 (2), 17974280 (1)
    inflammation 32.3 33 9796991 (3), 15962097 (3), 19104500 (2), 9831319 (1) (see all 21)
    premalignant 27 6 10448305 (1), 19351789 (1), 19101730 (1), 14695321 (1)
    tumors 24.8 58 16270603 (4), 19173988 (3), 17340616 (3), 18652761 (3) (see all 29)
    prostatic intraepithelial neoplasia 23.9 4 16324197 (2), 11801547 (1)
    colon adenocarcinoma 23.9 6 15526283 (3), 18541673 (2)
    oral cancer 21.1 6 18297688 (2), 20371204 (1), 12870656 (1)
    cancer 16.7 34 18663355 (4), 20215502 (2), 16324197 (2), 20371204 (1) (see all 15)
    metastasis 16.6 22 18535914 (3), 20353277 (3), 18776816 (3), 18223218 (2) (see all 11)

    Genetic Association Database (GAD): ANXA1
    Human Genome Epidemiology (HuGE) Navigator: ANXA1 (6 documents)

    Export disorders for ANXA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANXA1 gene, integrated from 10 sources (see all 550):
    (articles sorted by number of sources associating them with ANXA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. (PubMed id 2936963)1, 2, 3 Wallner B.P.... Pepinsky R.B. (Nature 1986)
    2. Crystal structure of human annexin I at 2.5-A resolution. (PubMed id 8453382)1, 2, 9 Weng X.... Huber R. (Protein Sci. 1993)
    3. Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. (PubMed id 16883066)1, 7, 9 Morand E.F....Yang Y.H. (Mediators Inflamm. 2006)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Phosphorylation of annexin I by TRPM7 channel-kinase. (PubMed id 15485879)1, 2 Dorovkov M.V. and Ryazanov A.G. (J. Biol. Chem. 2004)
    6. [Absence of evidence for the association of single nucleotide polymorphisms in Annexin A1 gene with type 2 diabetes in Chinese]. (PubMed id 15476183)1, 4 Dong Y....Luo M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Characterization of the annexin I gene and evaluation of its role in type 2 diabetes. (PubMed id 11574426)1, 4 Lindgren C.M....Groop L.C. (Diabetes 2001)
    9. NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit. (PubMed id 9915835)1, 2 Gao J.... Yan H. (J. Biol. Chem. 1999)
    10. Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. (PubMed id 8425544)1, 2 Arcone R.... Ciliberto G. (Eur. J. Biochem. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 301 HGNC: 533 AceView: ANXA1 Ensembl:ENSG00000135046 euGenes: HUgn301
    ECgene: ANXA1 H-InvDB: ANXA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANXA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANXA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANXA1 gene:
    Search GeneIP for patents involving ANXA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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