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Aliases & Descriptions for ANTXR1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases 2310008J16Rik 2 2810405N18Rik 2 ATR 1 , 2 , 3 , 5 FLJ10601 1 , 2 FLJ11298 2 FLJ21776 1 , 2 TEM8 1 , 2 , 3 , 5
Descriptions Tumor endothelial marker 8 2 , 3 anthrax toxin receptor 1 2
Search outside databases for aliases for ANTXR1 genePrevious GC identifers: GC02P069198 GC02P069215
Summaries for ANTXR1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ANTXR1 : This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker thathas been implicated in colorectal cancer. The encoded protein has been shown to also be a dockingprotein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. Thebinding of the protective antigen (PA) component, of the tripartite anthrax toxin, to thisreceptor protein mediates delivery of toxin components to the cytosol of cells. Once inside thecell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disruptnormal cellular processes. Three alternatively spliced variants that encode different proteinisoforms have been described. [provided by RefSeq] UniProtKB/Swiss-Prot: ANTR1_HUMAN, Q9H6X2 Function : Cellular role is not yet known
Gene Wiki entry for ANTXR1
Genomic Location for ANTXR1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ANTXR1 gene Entrez Gene cytogenetic band: 2p13.1 Ensembl cytogenetic band: 2p14 HGNC cytogenetic band: 2p13.1 ANTXR1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P069152:
(about GC identifiers )
Start:
69,093,942 bp from pter
End:
69,329,806 bp from pter
Size:
235,865 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000002.10 NT_022184.14 Proteins for ANTXR1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ANTR1_HUMAN, Q9H6X2 (See
protein sequence )Recommended Name: Anthrax toxin receptor 1 precursor Size : 564 amino acids; 62789 Da
Subunit : Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in thepresence of calcium
Subcellular location : Membrane; Single-pass type I membrane protein (Probable)
Secondary accessions : Q96P02 Q9NVP3Alternative splicing : 4 isoforms : Q9H6X2-1 Q9H6X2-2 Q9H6X2-3 Q9H6X2-4 (Experimental confirmation may be lacking for some isoforms)
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_060623.2 NP_115584.1 NP_444262.1 ENSEMBL proteins: ENSP00000377852 ENSP00000310614 ENSP00000386494 ENSP00000301945 ENSP00000386855 ENSP00000387058 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016020 membrane
IEA -- GO:0016021 integral to membrane
IEA --
About this table Antibodies for ANTXR1: Assays for ANTXR1:
Protein
Domains/ Families for ANTXR1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9H6X2 ProtoNet protein and cluster: Q9H6X2
2 Blocks protein families : IPB002035 Von Willebrand factor type A domain signature IPB008399 Anthrax receptor UniProtKB/Swiss-Prot: ANTR1_HUMAN, Q9H6X2 Domain : Binding to PA seems to be effected through the VWA domainSimilarity : Belongs to the ATR familySimilarity : Contains 1 VWFA domain
Gene Function for ANTXR1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_032208 Applied Biosystems Silencer ® siRNAs for ANTXR1 Sigma-Aldrich siRNA and siRNA Panels for ANTXR1 Sigma-Aldrich shRNA for ANTXR1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_018153                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_018153                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_018153  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_032208 UniProtKB/Swiss-Prot: ANTR1_HUMAN, Q9H6X2 Function : Cellular role is not yet known
1 MGI phenotypic allele for Antxr1 (no phenotypes)3 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for ANTXR1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/10 Interacting proteins for ANTXR1 (ENSP00000301945 3 Q9H6X2 1 ) via UniProtKB, MINT, and/or STRING (see all 10
)About this table
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Novoseek and Drugs according to
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PharmGKB )
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Browse Tocris compounds for ANTXR1
Transcripts for ANTXR1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
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shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_032208 Sigma-Aldrich siRNA and siRNA Panels for ANTXR1 Sigma-Aldrich shRNA for ANTXR1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_018153 NM_032208 NM_053034
REFSEQ mRNAs for ANTXR1 gene (3 alternative transcripts): NM_018153.3 NM_032208.2 NM_053034.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018153 NM_032208 NM_053034
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_018153                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_018153                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_018153  
Additional cDNA sequence: AF090095.1 AF279145.2 AF421380.1 AK002160.1 AK025429.1 AK126783.1 AK223273.1 AK292113.1 AK309553.1 AL110155.1 BC012074.1 BC012475.1 CR601167.1 CR608949.1
23 DOTS entries : DT.100030836 DT.119004 DT.97775779 DT.101968313 DT.120969172 DT.309596 DT.120969196 DT.101976518 DT.120969200 DT.100821866 DT.100030845 DT.100821863 DT.120969213 DT.75107758 DT.95278535 DT.120969167 DT.120969219 DT.421219 DT.75179577 DT.91671089 DT.95125892 DT.100821867 DT.91726528
24/346 AceView cDNA sequences (see all 346
):BC012074 Z39069 AW118038 BQ575871 AA424878 CB215475 AI356731 AW296332 AI400227 AI379167 AW515125 AI242331 AL542724 CN483575 BX474676 T30707 BF793282 CB149116 AW207263 CR608949 AA478681 AA235039 AI018522 CB145982
highest scoring ESTs for ANTXR1 :AA146966 AA025124 AA025204 AA113076 AA126625 AA126731 AA127004 AA130039 AA130040 AA146967
Unigene Cluster for ANTXR1: Anthrax toxin receptor 1 Hs.165859 [show with all ESTs ] Unigene Representative Sequence: NM_032208 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ANTXR1 (see all 7
) ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ SP1 :                     -   -       -   -   -       -       -         SP2 :                     -   -       -   -   -       -               SP3 :                     -   -       -   -   -                     SP4 :                     -   -                               SP5 :                                                    
About this scheme ECgene alternative splicing isoforms for ANTXR1 6 Ensembl transcripts including schematic representations : ENST00000394317
ENST00000308181
ENST00000409349
ENST00000303714
ENST00000409608
ENST00000409829
Expression for ANTXR1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ANTXR1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ANTXR1 1 / 2 / 3
11 probe-sets matching ANTXR1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CTATAGGAGASOURCE GeneReport for Unigene cluster: Hs.165859 Expression variation in blood from EXPOLDB for ANTXR1
UniProtKB/Swiss-Prot: ANTR1_HUMAN, Q9H6X2 Tissue specificity : Highly expressed in tumor endothelial cells but not in normal endothelial cells
Orthologs for ANTXR1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ANTXR1 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for ANTXR1 ENSEMBL Gene Tree for ANTXR1 Paralogs for ANTXR1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ANTXR1 gene ANTXRL 2 ANTXR2 2
SNPs/Variants for ANTXR1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ANTXR1 (up to first 250kb)
Disorders & Mutations for ANTXR1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 606410 disorders : 602089
3 Novoseek disease relationships for ANTXR1 gene
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Medical News for ANTXR1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ANTXR1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/38 PubMed articles for ANTXR1 gene (see all 38
): Genes expressed in human tumor endothelium. (PubMed id 10947988) 2, 3, 4 St Croix B....Kinzler K.W. (2000) Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. (PubMed id 12700348) 1, 3, 4 Scobie H.M....Young J.A. (2003) Identification of the cellular receptor for anthrax toxin. (PubMed id 11700562) 1, 3, 4 Bradley K.A.... Young J.A.T. (2001) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) An unappreciated role for RNA surveillance. (PubMed id 14759258) 3, 4 Hillman R.T.... Brenner S.E. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Cell surface tumor endothelial markers are conserved in mice and humans. (PubMed id 11559528) 2, 3 Carson-Walter E.B....St Croix B. (2001) Receptor-specific requirements for anthrax toxin delivery into cells. (PubMed id 16141341) 1, 3 Rainey G.J....Young J.A. (2005) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107) 4 Rikova K....Comb M.J. (2007)
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Genome Databases showing ANTXR1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ANTXR1
(According to HUGE )
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Specialized Databases showing ANTXR1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ANTXR1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for ANTXR1:
Recombinant Proteins (TEM8 ) Antibodies (TEM8 )
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