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Aliases for ANPEP Gene

Aliases for ANPEP Gene

  • Alanyl (Membrane) Aminopeptidase 2 3
  • Microsomal Aminopeptidase 2 3 4
  • Aminopeptidase M 2 3 4
  • Myeloid Plasma Membrane Glycoprotein CD13 3 4
  • Alanyl Aminopeptidase 3 4
  • EC 3.4.11.2 4 63
  • GP150 3 4
  • CD13 3 4
  • PEPN 3 4
  • AP-M 3 4
  • AP-N 3 4
  • HAPN 3 4
  • APN 3 4
  • Aminopeptidase N 2
  • CD13 Antigen 4
  • EC 3.4.11 63
  • LAP1 3
  • P150 3

External Ids for ANPEP Gene

Previous HGNC Symbols for ANPEP Gene

  • CD13
  • PEPN

Previous GeneCards Identifiers for ANPEP Gene

  • GC15M086732
  • GC15M083693
  • GC15M087915
  • GC15M088057
  • GC15M088129
  • GC15M090328
  • GC15M066440

Summaries for ANPEP Gene

Entrez Gene Summary for ANPEP Gene

  • Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANPEP Gene

ANPEP (Alanyl (Membrane) Aminopeptidase) is a Protein Coding gene. Diseases associated with ANPEP include tetrasomy 21 and acute leukemia of ambiguous lineage. Among its related pathways are Cardiac Progenitor Differentiation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include receptor activity and virus receptor activity. An important paralog of this gene is ERAP1.

UniProtKB/Swiss-Prot for ANPEP Gene

  • Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.

  • (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E.

Tocris Summary for ANPEP Gene

  • Aminopeptidases catalyze the removal of amino acids from the amino terminus of proteins and peptides. They express different substrate specificities - for example, leucyl aminopeptidase preferentially cleaves leucine residues.

Gene Wiki entry for ANPEP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANPEP Gene

Genomics for ANPEP Gene

Regulatory Elements for ANPEP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANPEP Gene

Chromosome:
15
Start:
89,784,889 bp from pter
End:
89,815,401 bp from pter
Size:
30,513 bases
Orientation:
Minus strand

Genomic View for ANPEP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANPEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANPEP Gene

Proteins for ANPEP Gene

  • Protein details for ANPEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15144-AMPN_HUMAN
    Recommended name:
    Aminopeptidase N
    Protein Accession:
    P15144
    Secondary Accessions:
    • Q16728
    • Q6GT90
    • Q8IUK3
    • Q8IVH3
    • Q9UCE0

    Protein attributes for ANPEP Gene

    Size:
    967 amino acids
    Molecular mass:
    109540 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homodimer. (Microbial infection) Interacts with the S1 domain of human coronavirus 229E/HCoV-229E spike protein (PubMed:1350662, PubMed:12551991).
    Miscellaneous:
    • Found to serve as a receptor for tumor-homing peptides, more specifically NGR peptides. It could serve thus as a target for delivering drugs into tumors. Concentration in human hepatic bile, varies from 17.3 to 57.6 micrograms/ml

    Three dimensional structures from OCA and Proteopedia for ANPEP Gene

neXtProt entry for ANPEP Gene

Proteomics data for ANPEP Gene at MOPED

Post-translational modifications for ANPEP Gene

Other Protein References for ANPEP Gene

Antibody Products

  • R&D Systems Antibodies for ANPEP (Aminopeptidase N/CD13)
  • Cell Signaling Technology (CST) Antibodies for ANPEP (CD13)

Protein Products

Domains & Families for ANPEP Gene

Gene Families for ANPEP Gene

Protein Domains for ANPEP Gene

Suggested Antigen Peptide Sequences for ANPEP Gene

Graphical View of Domain Structure for InterPro Entry

P15144

UniProtKB/Swiss-Prot:

AMPN_HUMAN :
  • Amino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies)
  • Belongs to the peptidase M1 family.
Domain:
  • Amino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies)
Family:
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with ANPEP: view

Function for ANPEP Gene

Molecular function for ANPEP Gene

GENATLAS Biochemistry:
membrane leucyl aminopeptidase N,p150
UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal amino acid, Xaa- -Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
UniProtKB/Swiss-Prot Function:
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E.
UniProtKB/Swiss-Prot Induction:
Estradiol and IL8/interleukin-8 decrease enzymatic activity in vitro in endometrial stromal cells by 40% and 30%, respectively.

Enzyme Numbers (IUBMB) for ANPEP Gene

Gene Ontology (GO) - Molecular Function for ANPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004177 aminopeptidase activity TAS 10734069
GO:0004872 receptor activity TAS 1350662
GO:0008237 metallopeptidase activity TAS 2564851
GO:0008270 zinc ion binding IBA --
genes like me logo Genes that share ontologies with ANPEP: view
genes like me logo Genes that share phenotypes with ANPEP: view

Animal Models for ANPEP Gene

MGI Knock Outs for ANPEP:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANPEP

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ANPEP Gene

Localization for ANPEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANPEP Gene

Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol. Note=A soluble form has also been detected.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANPEP Gene COMPARTMENTS Subcellular localization image for ANPEP gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
plasma membrane 4
cytosol 3
cytoskeleton 2
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005765 lysosomal membrane IDA 17897319
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005829 cytosol IEA --
GO:0005887 integral component of plasma membrane TAS 2564851
genes like me logo Genes that share ontologies with ANPEP: view

Pathways & Interactions for ANPEP Gene

genes like me logo Genes that share pathways with ANPEP: view

Pathways by source for ANPEP Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for ANPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0002003 angiotensin maturation TAS --
GO:0006508 proteolysis IBA --
GO:0030154 cell differentiation IEA --
GO:0043171 peptide catabolic process IBA --
genes like me logo Genes that share ontologies with ANPEP: view

No data available for SIGNOR curated interactions for ANPEP Gene

Drugs & Compounds for ANPEP Gene

(48) Drugs for ANPEP Gene - From: NovoSeek, HMDB, ApexBio, DGIdb, Tocris, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ezetimibe Approved Pharma Target, other Cholesterol transport inhibitor 252
Icatibant Approved Pharma Antagonist, Target, inhibitor 16
Zinc Approved Pharma 1404
Glycine Approved Nutra Agonist Endogenous potentiator, co-transmitter 102
L-Cysteine Approved Nutra 0

(53) Additional Compounds for ANPEP Gene - From: NovoSeek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cysteinylglycine
  • Cys-Gly
  • L-Cysteinylglycine
  • N-Cysteinyl Glycine
  • N-Cysteinyl-Glycine
  • N-L-Cysteinyl-Glycine
19246-18-5
Oxidized glutathione
  • (2S)-2-azaniumyl-4-{[(1R)-2-{[(2R)-2-[(4S)-4-azaniumyl-4-carboxylatobutanamido]-2-[(carboxylatomethyl)carbamoyl]ethyl]disulfanyl}-1-[(carboxylatomethyl)carbamoyl]ethyl]carbamoyl}butanoate
  • Glutathione disulfide
  • GSSG
  • L(-)-Glutathione(oxidized)
  • Oxiglutatione
27025-41-8
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
CHR 2797
238750-77-1
SC 57461A
423169-68-0
genes like me logo Genes that share compounds with ANPEP: view

Drug Products

Transcripts for ANPEP Gene

Unigene Clusters for ANPEP Gene

Alanyl (membrane) aminopeptidase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANPEP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANPEP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - -
SP2: -
SP3:
SP4:
SP5:

ExUns: 21
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ANPEP Gene

GeneLoc Exon Structure for
ANPEP
ECgene alternative splicing isoforms for
ANPEP

Expression for ANPEP Gene

mRNA expression in normal human tissues for ANPEP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANPEP Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x11.3), Pancreas (x10.0), Whole Blood (x5.6), and Liver (x4.2).

Protein differential expression in normal tissues from HIPED for ANPEP Gene

This gene is overexpressed in Pancreatic juice (20.1), Urine (13.5), Fetal gut (9.5), and Nasal epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANPEP Gene



SOURCE GeneReport for Unigene cluster for ANPEP Gene Hs.1239

mRNA Expression by UniProt/SwissProt for ANPEP Gene

P15144-AMPN_HUMAN
Tissue specificity: Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients
genes like me logo Genes that share expression patterns with ANPEP: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ANPEP Gene

Orthologs for ANPEP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANPEP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANPEP 35
  • 81.97 (n)
  • 78.09 (a)
ANPEP 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANPEP 35
  • 81.76 (n)
  • 78.28 (a)
ANPEP 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anpep 35
  • 78.22 (n)
  • 76.56 (a)
Anpep 16
Anpep 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANPEP 35
  • 98.97 (n)
  • 98.66 (a)
ANPEP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anpep 35
  • 79.15 (n)
  • 78.11 (a)
oppossum
(Monodelphis domestica)
Mammalia ANPEP 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANPEP 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANPEP 35
  • 71.46 (n)
  • 66.74 (a)
ANPEP 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANPEP 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anpep 35
  • 61.53 (n)
  • 59.94 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12671 35
zebrafish
(Danio rerio)
Actinopterygii LOC100535773 35
  • 61.7 (n)
  • 60.9 (a)
ANPEP (3 of 6) 36
  • 53 (a)
OneToMany
ANPEP (6 of 6) 36
  • 57 (a)
OneToMany
anpepb 36
  • 59 (a)
OneToMany
BX005410.1 36
  • 56 (a)
OneToMany
BX005410.2 36
  • 53 (a)
OneToMany
BX572619.7 36
  • 60 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9152 35
fruit fly
(Drosophila melanogaster)
Insecta BG:DS00365.1 37
  • 32 (a)
CG11951 37
  • 38 (a)
CG14516 37
  • 36 (a)
CG2111 37
  • 26 (a)
CG3502 37
  • 29 (a)
CG5849 37
  • 25 (a)
CG6071 37
  • 25 (a)
CG8773 37
  • 36 (a)
CG9806 37
  • 27 (a)
sda 37
  • 33 (a)
SP1029 37
  • 32 (a)
CG14516 35
  • 51.06 (n)
  • 38.84 (a)
CG11951 36
  • 33 (a)
ManyToMany
CG14516 36
  • 34 (a)
ManyToMany
CG2111 36
  • 27 (a)
ManyToMany
CG31198 36
  • 29 (a)
ManyToMany
CG31233 36
  • 29 (a)
ManyToMany
CG31343 36
  • 27 (a)
ManyToMany
CG31445 36
  • 33 (a)
ManyToMany
CG3502 36
  • 28 (a)
ManyToMany
CG42335 36
  • 26 (a)
ManyToMany
CG5849 36
  • 22 (a)
ManyToMany
CG6071 36
  • 20 (a)
ManyToMany
CG7653 36
  • 29 (a)
ManyToMany
CG9806 36
  • 26 (a)
ManyToMany
sda 36
  • 24 (a)
ManyToMany
SP1029 36
  • 33 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013001 35
  • 53.38 (n)
  • 42.41 (a)
worm
(Caenorhabditis elegans)
Secernentea AC3.5 37
  • 22 (a)
R03G8.4 37
  • 27 (a)
R03G8.6 37
  • 30 (a)
T07F10.1 37
  • 29 (a)
T12E12.6 37
  • 28 (a)
T16G12.1 37
  • 27 (a)
Y42A5A.1 37
  • 30 (a)
Y67D8C.9 37
  • 33 (a)
T07F10.1 36
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAP1 36
  • 30 (a)
ManyToMany
APE2 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
Species with no ortholog for ANPEP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANPEP Gene

ENSEMBL:
Gene Tree for ANPEP (if available)
TreeFam:
Gene Tree for ANPEP (if available)

Paralogs for ANPEP Gene

Paralogs for ANPEP Gene

(9) SIMAP similar genes for ANPEP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ANPEP: view

Variants for ANPEP Gene

Sequence variations from dbSNP and Humsavar for ANPEP Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3934 -- 89,797,494(-) ACTAT(A/C/G/T)GCCTA intron-variant
rs10584 -- 89,785,320(-) GCCCC(C/G)ATGCA utr-variant-3-prime
rs12921 -- 89,797,684(-) CAACA(C/G)CCTCT reference, missense, intron-variant
rs25651 - 89,792,557(-) GTACA(A/G)CGAGG missense, reference, downstream-variant-500B
rs25652 -- 89,792,303(-) TCCAC(A/C/G/T)GTCTA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ANPEP Gene

Variant ID Type Subtype PubMed ID
dgv2434n71 CNV Loss 21882294
nsv819621 CNV Gain 19587683
nsv519689 CNV Loss 19592680
nsv1661 CNV Insertion 18451855

Variation tolerance for ANPEP Gene

Residual Variation Intolerance Score: 35.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 62.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANPEP Gene

HapMap Linkage Disequilibrium report
ANPEP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANPEP Gene

Disorders for ANPEP Gene

MalaCards: The human disease database

(13) MalaCards diseases for ANPEP Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
tetrasomy 21
  • isochromosome 21
acute leukemia of ambiguous lineage
  • acute biphenotypic leukemia
aleukemic leukemia cutis
mast-cell sarcoma
  • mast cell sarcoma
gastroenteritis
  • infectious colitis, enteritis and gastroenteritis
- elite association
Search ANPEP in MalaCards View complete list of genes associated with diseases

Relevant External Links for ANPEP

Genetic Association Database (GAD)
ANPEP
Human Genome Epidemiology (HuGE) Navigator
ANPEP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANPEP
genes like me logo Genes that share disorders with ANPEP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANPEP Gene

Publications for ANPEP Gene

  1. Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane. (PMID: 15494415) Kramer W. … Schmitz G. (J. Biol. Chem. 2005) 23 25 26 67
  2. Expression of CD13/aminopeptidase N in precursor B-cell leukemia: role in growth regulation of B cells. (PMID: 19562339) Saxena A. … Mitra D.K. (Cancer Immunol. Immunother. 2010) 23 67
  3. The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan. (PMID: 20067771) WickstrAPm M. … Gullbo J. (Biochem. Pharmacol. 2010) 23 67
  4. Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma. (PMID: 20346382) Loi M. … Pastorino F. (J Control Release 2010) 23 67
  5. [Expression of mitochondrial ferritin in K562 leukemic cell during ATRA-induced cell differentiation]. (PMID: 20369475) Sun L. … Yuan L.X. (Sichuan Da Xue Xue Bao Yi Xue Ban 2010) 23 67

Products for ANPEP Gene

Sources for ANPEP Gene

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