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ANPEP Gene

protein-coding   GIFtS: 75
GCID: GC15M090328

Alanyl (Membrane) Aminopeptidase


(Previous symbols: CD13, PEPN)
  See ANPEP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Alanyl (Membrane) Aminopeptidase1 2     APN2 3
CD131 2 3 5     hAPN2 3
PEPN1 2 3 5     EC 3.4.11.23 8
Aminopeptidase M1 2 3     GP1502
Microsomal Aminopeptidase1 2 3     LAP12
Aminopeptidase N1 2     P1502
Alanyl Aminopeptidase2 3     CD13 Antigen3
Myeloid Plasma Membrane Glycoprotein CD132 3     gp1503
AP-M2 3     EC 3.4.118
AP-N2 3     

External Ids:    HGNC: 5001   Entrez Gene: 2902   Ensembl: ENSG000001668257   OMIM: 1515305   UniProtKB: P151443   

Export aliases for ANPEP gene to outside databases

Previous GC identifers: GC15M086732 GC15M083693 GC15M087915 GC15M088057 GC15M088129 GC15M066440


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANPEP Gene:
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma
membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from
hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and
other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus
sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with
known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to
be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal
tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N
is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract
infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ANPEP Gene:
ANPEP (alanyl (membrane) aminopeptidase) is a protein-coding gene. Diseases associated with ANPEP include gastroenteritis, and familial chronic lymphocytic leukemia. GO annotations related to this gene include aminopeptidase activity and receptor activity. An important paralog of this gene is LNPEP.

UniProtKB/Swiss-Prot: AMPN_HUMAN, P15144
Function: Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from
hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of
cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types,
responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and
chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of
presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of
IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used
as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E
(HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human
cytomegalovirus (HCMV) infection

summary for ANPEP Gene:
Aminopeptidases catalyze the removal of amino acids from the amino terminus of proteins and peptides. They
express different substrate specificities - for example, leucyl aminopeptidase preferentially cleaves
leucine residues.

Gene Wiki entry for ANPEP (Alanine aminopeptidase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANPEP gene promoter:
         HFH-3   Elk-1   FOXD1   Nkx2-5   C/EBPalpha   FOXI1   N-Myc   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANPEP promoter sequence
   Search Chromatin IP Primers for ANPEP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANPEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25-q26   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q25-q26

ANPEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANPEP gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M090328:  view genomic region     (about GC identifiers)

Start:
90,328,120 bp from pter      End:
90,358,633 bp from pter
Size:
30,514 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AMPN_HUMAN, P15144 (See protein sequence)
Recommended Name: Aminopeptidase N  
Size: 967 amino acids; 109540 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Homodimer. Interacts with the S1 domain of HCoV-229E spike protein
Miscellaneous: Found to serve as a receptor for tumor-homing peptides, more specifically NGR peptides. It could
serve thus as a target for delivering drugs into tumors. Concentration in human hepatic bile, varies from 17.3 to
57.6 micrograms/ml
4 PDB 3D structures from and Proteopedia for ANPEP:
4FYQ (3D)        4FYR (3D)        4FYS (3D)        4FYT (3D)    
Secondary accessions: Q16728 Q6GT90 Q8IUK3 Q8IVH3 Q9UCE0

Explore the universe of human proteins at neXtProt for ANPEP: NX_P15144

Explore proteomics data for ANPEP at MOPED

Post-translational modifications: 

  • Sulfated (By similarity)1
  • N- and O-glycosylated1
  • May undergo proteolysis and give rise to a soluble form1
  • Glycosylation2 at Asn128, Asn234, Asn265, Asn319, Asn527, Asn573, Asn625, Asn681, Asn735, Asn818
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ANPEP (P15144) (see all 24)
     WFGNLVT  SNWKKLF  STVRFTC  WLNEGFA 


    See ANPEP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001141.2  
    ENSEMBL proteins: 
     ENSP00000300060   ENSP00000453545   ENSP00000453405   ENSP00000452934   ENSP00000453413  
    Reactome Protein details: P15144

    ANPEP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for ANPEP
    OriGene Purified Protein for ANPEP
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ANPEP
    GenScript Custom Purified and Recombinant Proteins Services for ANPEP
    Novus Biologicals ANPEP Proteins
    Novus Biologicals ANPEP Lysates
    Sino Biological Recombinant Protein for ANPEP
    Sino Biological Cell Lysate for ANPEP
    ProSpec Recombinant Protein for ANPEP
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ANPEP 

     
    antibodies-online proteins for ANPEP (8 products) 

     
    antibodies-online peptides for ANPEP

    ANPEP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANPEP
    R&D Systems Antibodies for ANPEP (Aminopeptidase N/ANPEP)
    OriGene Antibodies for ANPEP
    OriGene Custom Antibody Services for ANPEP
    Novus Biologicals ANPEP Antibodies
    Abcam antibodies for ANPEP
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ANPEP
    antibodies-online antibodies for ANPEP (234 products) 

    ANPEP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ANPEP
    R&D Systems ELISAs for ANPEP (Aminopeptidase N/ANPEP)         (see all)
    GenScript Custom Assay Services for ANPEP
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ANPEP 
    antibodies-online kits for ANPEP (19 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: Aminopeptidase N
    Aminopeptidases

    3 InterPro protein domains:
     IPR014782 Peptidase_M1_N
     IPR024571 ERAP1-like_C_dom
     IPR001930 Peptidase_M1

    Graphical View of Domain Structure for InterPro Entry P15144

    ProtoNet protein and cluster: P15144

    1 Blocks protein domain: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: AMPN_HUMAN, P15144
    Domain: Amino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human
    chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies)
    Similarity: Belongs to the peptidase M1 family


    Find genes that share domains with ANPEP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMPN_HUMAN, P15144
    Function: Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from
    hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of
    cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types,
    responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and
    chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of
    presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of
    IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used
    as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E
    (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human
    cytomegalovirus (HCMV) infection
    Catalytic activity: Release of an N-terminal amino acid, Xaa- -Yaa- from a peptide, amide or arylamide. Xaa is
    preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is
    followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide
    Induction: Estradiol and IL8/interleukin-8 decrease enzymatic activity in vitro in endometrial stromal cells by
    40% and 30%, respectively

         Genatlas biochemistry entry for ANPEP:
    membrane leucyl aminopeptidase N,p150

         Enzyme Numbers (IUBMB): EC 3.4.11.21 2 EC 3.4.112

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0004177aminopeptidase activity IEA--
    GO:0004872receptor activity TAS1350662
    GO:0008237metallopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ANPEP           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Anpep):
     cardiovascular system  hematopoietic system  immune system  reproductive system  vision/eye 

    Find genes that share phenotypes with ANPEP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ANPEP: Anpeptm1.1Lsha Anpeptm1Sid

       genOway: Develop your customized and physiologically relevant rodent model for ANPEP

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANPEP:
    hsa-mir-1 (MIRT001389), hsa-mir-24-3p (MIRT030575), hsa-mir-124-3p (MIRT022990), hsa-mir-155-5p (MIRT020955), hsa-mir-30a-5p (MIRT005211), hsa-mir-16-5p (MIRT031867)

    Block miRNA regulation of human, mouse, rat ANPEP using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ANPEP:
    hsa-miR-4324 hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-670 hsa-miR-125b hsa-miR-1267 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidANPEP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANPEP
    Predesigned siRNA for gene silencing in human, mouse, rat ANPEP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ANPEP

    Clone
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    OriGene clones in human, mouse for ANPEP (see all 7)
    OriGene ORF clones in mouse, rat for ANPEP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANPEP (NM_001150)
    Sino Biological Human cDNA Clone for ANPEP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANPEP

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ANPEP
    Browse ESI BIO Cell Lines and PureStem Progenitors for ANPEP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANPEP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMPN_HUMAN, P15144: Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol (Potential). Note=A
    soluble form has also been detected
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    endoplasmic reticulum2
    extracellular2
    golgi apparatus2
    cytoskeleton1
    endosome1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA15308636
    GO:0005829cytosol IEA--
    GO:0005887integral component of plasma membrane TAS2564851
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with ANPEP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANPEP About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Glutathione metabolism
    Glutathione metabolism0.65
    Glutathione metabolism0.45
    Glutathione metabolism0.65
    glutathione-mediated detoxification I0.42
    2Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Metabolism of Angiotensinogen to Angiotensins0.00
    3Metabolism
    Metabolic pathways0.38
    4Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Renin-angiotensin system0.37
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with ANPEP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ANPEP
        Glutathione metabolism

    5 BioSystems Pathways for ANPEP
        Cardiac Progenitor Differentiation
    glutathione-mediated detoxification I
    C-MYB transcription factor network
    Glutathione metabolism
    gamma-glutamyl cycle


    1 Reactome Pathway for ANPEP
        Metabolism of Angiotensinogen to Angiotensins


    4 Kegg Pathways  (Kegg details for ANPEP):
        Glutathione metabolism
    Metabolic pathways
    Renin-angiotensin system
    Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ANPEP: 
              Mesenchymal Stem Cell in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANPEP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANPEP (P151442, 3 ENSP000003000604) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3, ENSP000003409894MINT-8010124 I2D: score=1 STRING: ENSP00000340989
    ATP1A1P050233, ENSP000002955984I2D: score=1 STRING: ENSP00000295598
    TM4SF1P304083, ENSP000003042774I2D: score=1 STRING: ENSP00000304277
    VCPP550723, ENSP000003517774I2D: score=1 STRING: ENSP00000351777
    ATP1B1P050263, ENSP000003567894I2D: score=1 STRING: ENSP00000356789
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0002003angiotensin maturation TAS--
    GO:0006508proteolysis ----
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    Find genes that share ontologies with ANPEP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ANPEP
    4 ApexBio Compounds for ANPEP     About this table
    CompoundAction CAS #
    BestatinSpecific inhibitor of aminopeptidase B and leucine aminopeptidase[58970-76-6]
    Fumagillininhibits methionine aminopeptidase-2[23110-15-8]
    SC 57461APotent and selective inhibitor of LTA4 hydrolase[423169-68-0]
    Tosedostat (CHR2797)aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N[238750-77-1]

    Compounds for ANPEP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BestatinAminopeptidase inhibitor[58970-76-6]
    SC 57461ASelective inhibitor of LTA4 hydrolase[423169-68-0]
    CHR 2797Aminopeptidase inhibitor[238750-77-1]

    7 HMDB Compounds for ANPEP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CysteinylglycineL-Cysteinylglycine (see all 5)19246-18-5--
    Glycine2-Aminoacetate (see all 15)56-40-6--
    L-Cysteine(+)-2-Amino-3-mercaptopropionic acid (see all 37)52-90-4--
    Manganesemanganese 7439-96-5--
    Oxidized glutathioneGSSG (see all 4)27025-41-8--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZincZinc (see all 2)7440-66-6--

    2 DrugBank Compounds for ANPEP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ezetimibe-- 163222-33-1targetother15494415
    Icatibant-- 130308-48-4targetinhibitor17026984

    Selected Novoseek inferred chemical compound relationships for ANPEP gene (see all 88)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bestatin 89.8 67 12443882 (3), 16704492 (3), 11042531 (3), 7913090 (2) (see all 39)
    actinonin 87.3 19 14757368 (2), 10873564 (1), 18973761 (1), 8141778 (1) (see all 13)
    leuhistin 84.5 3 10873564 (1), 1676999 (1), 8820902 (1)
    probestin 82.5 4 1686972 (1), 8920985 (1), 9813136 (1), 8101091 (1)
    amastatin 78.6 8 16368899 (1), 8971937 (1), 8095183 (1), 7907864 (1) (see all 7)
    n-phenylphthalimide 70 3 10445048 (2)
    alanine-p-nitroanilide 68.2 3 17649820 (1), 11556847 (1)
    arphamenine b 66.2 1 8820902 (1)
    alpha-naphthyl butyrate 59.4 1 8590773 (1)
    phosphoramidon 57.3 1 8971937 (1)



    Find genes that share compounds with ANPEP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANPEP gene: 
    NM_001150.2  

    Unigene Cluster for ANPEP:

    Alanyl (membrane) aminopeptidase
    Hs.1239  [show with all ESTs]
    Unigene Representative Sequence: NM_001150
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300060(uc002bop.4) ENST00000558740 ENST00000559761 ENST00000558177
    ENST00000560030 ENST00000559887 ENST00000560028 ENST00000559874 ENST00000560137

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate ANPEP:
    hsa-miR-4324 hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-670 hsa-miR-125b hsa-miR-1267 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidANPEP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANPEP
    Clone
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    OriGene ORF clones in mouse, rat for ANPEP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANPEP (NM_001150)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANPEP
    Primer
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    OriGene qPCR primer pairs and template standards for ANPEP
    OriGene qSTAR qPCR primer pairs in human, mouse for ANPEP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANPEP
      QuantiTect SYBR Green Assays in human, mouse, rat ANPEP
      QuantiFast Probe-based Assays in human, mouse, rat ANPEP

    Additional mRNA sequence: 

    AB209918.1 AF290544.1 AK298134.1 AK298242.1 AK298339.1 AK300946.1 BC058928.1 M22324.1 
    X13276.1 

    14 DOTS entries:

    DT.80100954  DT.121044920  DT.91698655  DT.92434874  DT.100037123  DT.121044941  DT.92434884  DT.95077839 
    DT.100790759  DT.100790760  DT.102824467  DT.450418  DT.91684122  DT.92434875 

    Selected AceView cDNA sequences (see all 341):

    BE910334 BQ228400 BI870154 CR595462 NM_001150 AA345715 BM849440 BQ009727 
    BM708132 BG034802 AA377174 R95125 T78483 BI870009 CA426127 BM846566 
    CD610829 N55345 BQ010173 BU685059 BG236121 AA649955 N95338 BC058928 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ANPEP    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                          -                                         -                 -                                   -                                 
    SP2:                                                                                      -                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ANPEP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANPEP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCTGTCG
    ANPEP Expression
    About this image


    ANPEP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 26) fully expand
     
     Mesenchymal Stem Cells
             Chorionic Mesenchymal Stromal Cells Chorionic Villus
             Umbilical cord blood-derived mesenchymal stem/progenitor cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 11 entries
             Mesenchymal Stem Cells Subcutaneous White Adipose
             Adipose-derived stromal cells
             Adipocyte-like cells
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 6 entries
             Mesenchymal Stem Cells Wharton's Jelly
             Umbilical Veins
             Umbilical tissue-derived cells (CNTO2476)
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 3 entries
             Chorionic Mesenchymal Stromal Cells Chorionic Villus
             Placenta-derived mesenchymal stem cells (family)
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Granulocyte-Monocyte Progenitor Cells Hematopoietic Bone Marrow
    ANPEP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANPEP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1239

    UniProtKB/Swiss-Prot: AMPN_HUMAN, P15144
    Tissue specificity: Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes,
    monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of
    cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found
    in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from
    multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is
    found to be elevated in plasma and effusions of cancer patients

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ANPEP gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anpep1 , 5 alanyl (membrane) aminopeptidase1, 5 78.22(n)1
    76.56(a)1
      7 (45.19 cM)5
    167901  NM_008486.21  NP_032512.21 
     798218035 
    chicken
    (Gallus gallus)
    Aves ANPEP1 alanyl (membrane) aminopeptidase 71.46(n)
    66.74(a)
      395667  NM_204861.1  NP_990192.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANPEP6
    alanyl (membrane) aminopeptidase
    58(a)
    1 ↔ 1
    GL344154.1(28805-60169)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.126712 Xenopus laevis transcribed sequence with weak similarity more 73.83(n)    CB208193.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005357731 aminopeptidase N-like 61.7(n)
    60.9(a)
      100535773  XM_003201402.2  XP_003201450.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119513
    CG145161
    membrane alanyl aminopeptidase3
    CG145161
    38(a)
    (best of 11)3
    51.06(n)1
    38.84(a)1
      99A43
    434441  NM_001276126.11  NP_001263055.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y67D8C.93   -- 33(a)
    (best of 8)
      IV(3077664-3086852)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AAP16
    APE26
    Arginine/alanine aminopeptidase, overproduction st...
    Aminopeptidase yscII; may have a role in obtaining...
    30(a)
    28(a)
    many ↔ many
    many ↔ many
    VIII(198740-201310) YHR047C
    XI(154991-158232) YKL157W


    ENSEMBL Gene Tree for ANPEP (if available)
    TreeFam Gene Tree for ANPEP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANPEP gene
    LNPEP2  ENPEP2  TRHDE2  LOC1010602122  ERAP12  NPEPPS2  AQPEP2  ERAP22  
    9 SIMAP similar genes for ANPEP using alignment to 5 protein entries:     AMPN_HUMAN (see all proteins):
    LOC100510707    ERAP2    NPEPPS    ENPEP    FLJ90650    TRHDE
    AQPEP    ERAP1    LNPEP

    Find genes that share paralogs with ANPEP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANPEP (see all 986)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7512181,2
    C,F,A,H--90327668(-) CAATGC/AGGGAC 1 -- ds50015Minor allele frequency- A:0.05NS EA WA 536
    rs1902424711,2
    --90327717(+) GGGCAC/TGGCCA 1 -- ds50010--------
    rs80350891,2
    C,F,H--90327807(+) CACTCA/GCTGCG 1 -- ds500127Minor allele frequency- N:0.00EA NA NS WA CSA 2558
    rs1820569071,2
    --90327931(+) GAGCCC/TGGAGT 1 -- ds50010--------
    rs615920961,2
    C--90327964(+) CAGGCG/TCAGGG 1 -- ds50013Minor allele frequency- T:0.08NA WA 124
    rs601474161,2
    C,F--90327979(+) TGCAGG/TAAGGG 1 -- ds50012Minor allele frequency- T:0.06NA 122
    rs80348071,2
    C,F,H--90327985(+) AAGGGC/ACGGCA 1 -- ds500113Minor allele frequency- A:0.23NS EA NA WA CSA 758
    rs9674511,2
    C,F,H--90328044(+) TGCTCC/TGCATG 1 -- ds50018Minor allele frequency- T:0.04EA NA NS WA 592
    rs10424991,2
    C,F--90328305(-) CAGGGA/GAGCCC 1 -- ut312Minor allele frequency- G:0.02MN NA 304
    rs785017931,2
    C,F--90328308(+) CTTCCC/TTGAGA 1 -- ut311Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for ANPEP (90328120 - 90358633 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ANPEP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1661CNV Insertion18451855
    nsv519689CNV Loss19592680
    dgv2434n71CNV Loss21882294
    nsv819621CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151530    OMIM disorders: --

    2 diseases for ANPEP:    
    About MalaCards
    gastroenteritis    familial chronic lymphocytic leukemia

    1 disease from the University of Copenhagen DISEASES database for ANPEP:
    Cancer

    Find genes that share disorders with ANPEP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ANPEP gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute undifferentiated leukemia 73 1 1518141 (1)
    porcine gastroenteritis transmissible 70.8 11 17093189 (1), 8970993 (1), 9782266 (1), 8887485 (1)
    t-all 68 7 1970448 (1), 11195181 (1), 17963747 (1), 17434163 (1)
    lymphoblastic leukemia acute 67 11 7556527 (2), 11855782 (1), 7686604 (1), 17963747 (1) (see all 9)
    b-all 66.8 10 19562339 (2), 11195181 (1), 11697497 (1), 11699224 (1) (see all 6)
    leukemia 66.4 31 15158090 (3), 11260074 (1), 15863212 (1), 17059770 (1) (see all 23)
    acute leukemia 64.6 6 12562262 (1), 11241503 (1), 8023515 (1), 1493908 (1) (see all 6)
    leukemia promyelocytic acute 52.4 4 17147245 (2), 15114596 (1), 7949141 (1)
    feline infectious peritonitis 50.9 4 9782265 (1), 8970993 (1), 8985407 (1)
    blood vessel tumors 44.4 5 16337683 (1), 11830545 (1), 20302845 (1), 20406925 (1)

    Genetic Association Database (GAD): ANPEP
    Human Genome Epidemiology (HuGE) Navigator: ANPEP (5 documents)

    Export disorders for ANPEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANPEP gene, integrated from 10 sources (see all 705):
    (articles sorted by number of sources associating them with ANPEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated. (PubMed id 7902291)1, 2, 9 Favaloro E.J.... Facey D. (Exp. Hematol. 1993)
    2. Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): influence of N-linked glycosylation. (PubMed id 11559807)1, 2, 9 Wentworth D.E. and Holmes K.V. (J. Virol. 2001)
    3. Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. (PubMed id 10676659)1, 2, 9 Pasqualini R.... Ruoslahti E. (Cancer Res. 2000)
    4. Variable O-glycosylation of CD13 (aminopeptidase N). (PubMed id 1705556)1, 2, 9 O'Connell P.J.... d'Apice A.J.F. (J. Biol. Chem. 1991)
    5. Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. (PubMed id 11384645)1, 2, 9 Seli E.... Arici A. (Fertil. Steril. 2001)
    6. CD13 (human aminopeptidase N) mediates human cytomegalovirus infection. (PubMed id 8105105)1, 2, 9 Soderberg C....Moller E. (J. Virol. 1993)
    7. Identification of residues critical for the human coronavirus 229E receptor function of human aminopeptidase N. (PubMed id 9367365)1, 2, 9 Kolb A.F.... Siddell S.G. (J. Gen. Virol. 1997)
    8. Defectively N-glycosylated and non-O-glycosylated aminopeptidase N (CD13) is normally expressed at the cell surface and has full enzymatic activity. (PubMed id 9056417)1, 2, 9 Noren K.... Vogel L.K. (Exp. Cell Res. 1997)
    9. Characterization of functional domains in the human coronavirus HCV 229E receptor. (PubMed id 8887485)1, 2, 9 Kolb A.F.... Siddell S.G. (J. Gen. Virol. 1996)
    10. Cholesterol crystallization-promoting activity of aminopeptidase-N isolated from the vesicular carrier of biliary lipids. (PubMed id 8102610)1, 2, 9 Nunez L....Nervi F. (FEBS Lett. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 290 HGNC: 500 AceView: ANPEP Ensembl:ENSG00000166825 euGenes: HUgn290
    ECgene: ANPEP Kegg: 290 H-InvDB: ANPEP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ANPEP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANPEP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANPEP gene:
    Search GeneIP for patents involving ANPEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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