ANPEP Gene
protein-coding GIFtS : 74 GCID: GC15 M090328
alanyl (membrane) aminopeptidase CD13, PEPN )
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Aliasesfor ANPEP gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Alanyl (Membrane) Aminopeptidase 1 2 AP-N2 3 CD131 2 3 5 APN2 3 PEPN1 2 3 5 HAPN1 LAP11 2 EC 3.4.11.23 8 Gp1501 P1502 Alanyl Aminopeptidase2 3 GP1502 Aminopeptidase M2 3 P1502 Microsomal Aminopeptidase2 3 Aminopeptidase N2 Myeloid Plasma Membrane Glycoprotein CD132 3 CD13 Antigen3 AP-M2 3 EC 3.4.118
Export aliases for ANPEP gene to outside databases Previous GC identifers: GC15M086732 GC15M083693 GC15M087915 GC15M088057 GC15M088129 GC15M066440
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Summariesfor ANPEP gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ANPEP : Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: AMPN_HUMAN, P15144 Function : Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysisof proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection summary
for ANPEP : Aminopeptidases catalyze the removal of amino acids from the amino terminus of proteins and peptides. Theyexpress different substrate specificities - for example, leucyl aminopeptidase preferentially cleavesleucine residues. Gene Wiki entry for ANPEP (Alanine aminopeptidase)
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Genomic Viewsfor ANPEP gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010274.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ANPEP gene promoter:HFH-3 Elk-1 FOXD1 Nkx2-5 C/EBPalpha FOXI1 N-Myc PPAR-gamma1 PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for ANPEP Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q25-q26 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q25-q26 ANPEP Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M090328: view genomic region
(about GC identifiers )
Start: 90,328,120 bp from pter End:
90,358,633 bp from pter
Size: 30,514 bases Orientation:
minus strand
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Proteinsfor ANPEP gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: AMPN_HUMAN, P15144 See
protein sequence )Recommended Name: Size : 967 amino acids; 109540 DaCofactor : Binds 1 zinc ion per subunitSubunit : Homodimer. Interacts with the S1 domain of HCoV-229E spike proteinSubcellular location : Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol (Potential). Note=Asoluble form has also been detected
Miscellaneous : Found to serve as a receptor for tumor-homing peptides, more specifically NGR peptides. It could servethus as a target for delivering drugs into tumors. Concentration in human hepatic bile, varies from 17.3 to 57.6 micrograms/ml
4 PDB 3D structures from :4FYQ (3D) 4FYR (3D) 4FYS (3D) 4FYT (3D) Secondary accessions : Q16728 Q6GT90 Q8IUK3 Q8IVH3 Q9UCE0Explore the universe of human proteins at neXtProt for ANPEP: NX_P15144 Post-translational modifications:
Sulfated (By similarity)1 N- and O-glycosylated1 May undergo proteolysis and give rise to a soluble form1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P15144 4/24 DME Specific Peptides for ANPEP (P15144 ) (see all 24 )ANPEP Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_001141.2 ENSEMBL proteins: ENSP00000300060 ENSP00000453545 ENSP00000453405 ENSP00000452934 ENSP00000453413 Reactome Protein details: P15144 Human Recombinant Protein Products: Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing ANPEP Antibody Products: Assay Products for ANPEP:
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Protein
Domains /for ANPEP gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P15144 ProtoNet protein and cluster: P15144
1 Blocks protein family : IPB001930 UniProtKB/Swiss-Prot: AMPN_HUMAN, P15144 Domain : Amino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/humanchimeric studies) and more specifically amino acids 288-295 (mutagenesis studies) Similarity : Belongs to the peptidase M1 family
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Functionfor ANPEP gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: AMPN_HUMAN, P15144 Function : Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysisof proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection Catalytic activity : Release of an N-terminal amino acid, Xaa- -Yaa- from a peptide, amide or arylamide. Xaa ispreferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide Induction : Estradiol and IL8/interleukin-8 decrease enzymatic activity in vitro in endometrial stromal cells by 40% and30%, respectively
Genatlas biochemistry entry for ANPEP membrane leucyl aminopeptidase N,p150 Enzyme Numbers (IUBMB): EC 3.4.11.2 1 2 EC 3.4.11 2 Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANPEP (NM_001150 ) Sino Biological Human cDNA Clone for ANPEP DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANPEP Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANPEP
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANPEP
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing Animal Models: Anpep tm1.1Lsha Anpep tm1Sid 5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Anpep) :About GeneDecksing
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Pathways & Interactionsfor ANPEP gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/8 super-pathways (see all 8 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Glutathione metabolism 2 Renin-angiotensin system 3 gamma-glutamyl cycle 4 C-MYB transcription factor network 5 Hematopoietic cell lineage
Pathway sources See GeneCards unified pathways Show all pathways 1 1 4 3 4 (Kegg details for ANPEP) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANPEP STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)5/29 Interacting proteins for ANPEP (P15144 2 , 3 ENSP00000300060 4 via UniProtKB, MINT, STRING , and/or I2D (see all 29 )About this table Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing
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Drugs & Compoundsfor ANPEP gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for ANPEP
Compounds for ANPEP available from Tocris Bioscience About this table Compound Action
CAS
# Bestatin Aminopeptidase inhibitor [58970-76-6] CHR 2797 Aminopeptidase inhibitor [238750-77-1]
7 HMDB Compounds for ANPEP About this table 2 DrugBank Compounds for ANPEP About this table 10/88 Novoseek chemical compound relationships for ANPEP gene (see all 88 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
bestatin
89.8
67
12443882 (3), 16704492 (3), 11042531 (3), 7913090 (2) (see all 39 )
actinonin
87.3
19
14757368 (2), 10873564 (1), 18973761 (1), 8141778 (1) (see all 13 )
leuhistin
84.5
3
10873564 (1), 1676999 (1), 8820902 (1)
probestin
82.5
4
1686972 (1), 8920985 (1), 9813136 (1), 8101091 (1)
amastatin
78.6
8
16368899 (1), 8971937 (1), 8095183 (1), 7907864 (1) (see all 7 )
n-phenylphthalimide
70
3
10445048 (2)
alanine-p-nitroanilide
68.2
3
17649820 (1), 11556847 (1)
arphamenine b
66.2
1
8820902 (1)
alpha-naphthyl butyrate
59.4
1
8590773 (1)
phosphoramidon
57.3
1
8971937 (1)
ANPEP / AMPN
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Transcriptsfor ANPEP gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ANPEP gene: NM_001150.2 Unigene Cluster for ANPEP:
Alanyl (membrane) aminopeptidase Hs.1239 [show with all ESTs ] Unigene Representative Sequence: NM_001150 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000300060 (uc002bop.4 ) ENST00000558740 ENST00000559761 ENST00000558177 ENST00000560030 ENST00000559887 ENST00000560028 ENST00000559874 ENST00000560137 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANPEP (NM_001150 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANPEP Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANPEP
Additional cDNA sequence: AB209918.1 AF290544.1 AK298134.1 AK298242.1 AK298339.1 AK300946.1 BC058928.1 M22324.1 X13276.1
14 DOTS entries : DT.80100954 DT.121044920
DT.91698655 DT.92434874 DT.100037123 DT.121044941 DT.92434884 DT.95077839 DT.100790759 DT.100790760 DT.102824467 DT.450418 DT.91684122 DT.92434875 24/341 AceView cDNA sequences (see all 341 ):
BU685059 BG119286 BE910334 AA377160 N95338 BQ228400 N55345 BM699278 BQ010173 BI870009 BC058928 BM991892 CA445264 BQ015324 BG236121 BU159111 CB154112 AA377174 CA426127 AA649955 BI870154 BQ009727 BM846566 NM_001150 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for ANPEP About this scheme ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ SP1 : - - - - SP2 : - SP3 : SP4 : SP5 :
ExUns: 21 SP1 : SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for ANPEP
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Expression for ANPEP gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ANPEP expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCACCTGTCG
About this image ANPEP expression in embryonic tissues and stem cells About this table See ANPEP Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ANPEP SOURCE GeneReport for Unigene cluster: Hs.1239 UniProtKB/Swiss-Prot: AMPN_HUMAN, P15144 Tissue specificity : Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes,monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients SABiosciences Expression via Pathway-Focused PCR Arrays including ANPEP : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANPEP
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Orthologsfor ANPEP gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ANPEP gene from 6/24 species (see all 24 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves ANPEP1
alanyl (membrane) aminopeptidase (aminopeptidase N, more
71.42(n) 66.35(a)
395667 NM_204861.1 NP_990192.1
lizard Reptilia ANPEP6
--
46(a)
1 ↔ 1
GL344154.1(29409-60169)
African clawed frog Amphibia Xl.126712
Xenopus laevis transcribed sequence with weak similarity more
73.83(n)
CB208193.1
zebrafish Actinopterygii LOC1005357731
aminopeptidase N-like
61.59(n) 60.79(a)
100535773 XM_003201402.1 XP_003201450.1
fruit fly Insecta CG119513 1
membrane alanyl aminopeptidase3 1
38(a) 3 51.24(n) 1 38.97(a) 1
99A43 43444 1 NM_143417.2 1 NP_651674.3 1
worm Secernentea Y67D8C.93
--
33(a)
IV(3077664-3086852) --
ENSEMBL Gene Tree for ANPEP (if available)TreeFam Gene Tree for ANPEP (if available)
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Paralogsfor ANPEP gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ANPEP gene LNPEP 2 ENPEP 2 TRHDE 2 ERAP1 2 AQPEP 2 NPEPPS 2 ENSG00000174093 2 ERAP2 2 9 SIMAP similar genes for ANPEP using alignment to 5 protein entries: AMPN_HUMAN (see all proteins ):TBC1D3 ERAP2 NPEPPS ENPEP FLJ90650 TRHDE AQPEP ERAP1 LNPEP About GeneDecksing
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Genomic Variantsfor ANPEP gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 15 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ANPEP (90328120 - 90358633 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for ANPEP 1 CNV 49619 1 Indel 58741
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ANPEP gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 151530
OMIM disorders : --20/110 (see all 110 ): About MalaCards leukemia/lymphoma leukemia anaplastic large cell lymphoma west nile virus mycosis fungoides mast-cell sarcoma prolymphocytic leukemia t-cell prolymphocytic leukemia b cell prolymphocytic leukemia pancreatitis malignant pleural mesothelioma clear cell renal cell carcinoma lymphocytic leukemia familial chronic lymphocytic leukemia chronic lymphocytic leukemia myelomonocytic leukemia lymphoblastic leukemia myeloproliferative disorder barrett's esophagus myeloid leukemia 1 disease from the University of Copenhagen DISEASES database for ANPEP :Cancer 10/91 Novoseek disease relationships for ANPEP gene (see all 91 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
acute undifferentiated leukemia
73
1
1518141 (1)
porcine gastroenteritis transmissible
70.8
11
17093189 (1), 8970993 (1), 9782266 (1), 8887485 (1)
t-all
68
7
1970448 (1), 11195181 (1), 17963747 (1), 17434163 (1)
lymphoblastic leukemia acute
67
11
7556527 (2), 11855782 (1), 7686604 (1), 17963747 (1) (see all 9 )
b-all
66.8
10
19562339 (2), 11195181 (1), 11697497 (1), 11699224 (1) (see all 6 )
leukemia
66.4
31
15158090 (3), 11260074 (1), 15863212 (1), 17059770 (1) (see all 23 )
acute leukemia
64.6
6
12562262 (1), 11241503 (1), 8023515 (1), 1493908 (1) (see all 6 )
leukemia promyelocytic acute
52.4
4
17147245 (2), 15114596 (1), 7949141 (1)
feline infectious peritonitis
50.9
4
9782265 (1), 8970993 (1), 8985407 (1)
blood vessel tumors
44.4
5
16337683 (1), 11830545 (1), 20302845 (1), 20406925 (1)
Genetic Association Database (GAD): ANPEP Human Genome Epidemiology (HuGE) Navigator: ANPEP (5 documents) Export disorders for ANPEP gene to outside databases
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Publicationsfor ANPEP gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ANPEP gene, integrated from 9 sources (see all 697 ):(articles sorted by number of sources associating them with ANPEP) Utopia : connect your pdf to the dynamic
CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated. (PubMed id 7902291) 1 , 2 , 9(1993) Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): influence of N-linked glycosylation. (PubMed id 11559807) 1 , 2 , 9(2001) Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. (PubMed id 10676659) 1 , 2 , 9(2000) Variable O-glycosylation of CD13 (aminopeptidase N). (PubMed id 1705556) 1 , 2 , 9(1991) Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. (PubMed id 11384645) 1 , 2 , 9(2001) CD13 (human aminopeptidase N) mediates human cytomegalovirus infection. (PubMed id 8105105) 1 , 2 , 9(1993) Identification of residues critical for the human coronavirus 229E receptor function of human aminopeptidase N. (PubMed id 9367365) 1 , 2 , 9(1997) Defectively N-glycosylated and non-O-glycosylated aminopeptidase N (CD13) is normally expressed at the cell surface and has full enzymatic activity. (PubMed id 9056417) 1 , 2 , 9(1997) Characterization of functional domains in the human coronavirus HCV 229E receptor. (PubMed id 8887485) 1 , 2 , 9(1996) Cholesterol crystallization-promoting activity of aminopeptidase-N isolated from the vesicular carrier of biliary lipids. (PubMed id 8102610) 1 , 2 , 9(1993)
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(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ANPEP gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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(According to HUGE )
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Specialized Databases showing ANPEP gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for ANPEP gene: ANPEP GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ANPEP gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for ANPEP OriGene shRNA RFP for ANPEP OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ANPEP OriGene 3'-UTR Clone for ANPEP OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ANPEP OriGene Custom Protein Services for ANPEP OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANPEP QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Tocris compounds for ANPEP
Recombinant Protein for ANPEP
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANPEP
ThermoFisher Antibody for ANPEP
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANPEP
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summary
for 
and Proteopedia 
for ANPEP:
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
