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ANP32E Gene

protein-coding   GIFtS: 53
GCID: GC01M150190

Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family,...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member E1 2
LANP-L2 3
LANP-Like Protein2 3
LANPL2 5
Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member E2
Leucine-Rich Acidic Nuclear Protein Like2

External Ids:    HGNC: 166731   Entrez Gene: 816112   Ensembl: ENSG000001434017   OMIM: 6096115   UniProtKB: Q9BTT03   

Export aliases for ANP32E gene to outside databases

Previous GC identifers: GC01M146965 GC01M147407 GC01M147003 GC01M148457 GC01M121570


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANP32E Gene:
ANP32E (acidic (leucine-rich) nuclear phosphoprotein 32 family, member E) is a protein-coding gene. GO annotations related to this gene include phosphatase inhibitor activity. An important paralog of this gene is ANP32D.

UniProtKB/Swiss-Prot: AN32E_HUMAN, Q9BTT0
Function: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the
nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator
regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B
dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits
activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar
development and synaptogenesis

Gene Wiki entry for ANP32E Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANP32E gene promoter:
         c-Fos   AP-1   MyoD   ZID   c-Jun   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANP32E promoter sequence
   Search Chromatin IP Primers for ANP32E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANP32E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q22

ANP32E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANP32E gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M150190:  view genomic region     (about GC identifiers)

Start:
150,190,717 bp from pter      End:
150,208,504 bp from pter
Size:
17,788 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AN32E_HUMAN, Q9BTT0 (See protein sequence)
Recommended Name: Acidic leucine-rich nuclear phosphoprotein 32 family member E  
Size: 268 amino acids; 30692 Da
Subunit: Interacts with the importin alpha KPNA1 and KPNA2 (By similarity). Component of a SWR1-like complex,
composed of EP400, KAT5/TIP60, TRRAP, BRD8, RUVBL1, RUVBL2, ING3 and ANP32E; the complex does not contain SRCAP.
Interacts with H2A.Z/H2AFZ
1 PDB 3D structure from and Proteopedia for ANP32E:
4CAY (3D)    
Secondary accessions: B4E0I6 E9PEA6 Q5TB18 Q5TB20 Q8N1S4 Q8WWW9
Alternative splicing: 3 isoforms:  Q9BTT0-1   Q9BTT0-2   Q9BTT0-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ANP32E: NX_Q9BTT0

Explore proteomics data for ANP32E at MOPED

Post-translational modifications: 

  • Phosphorylated. The phosphorylation is nuclear localization signal (NLS)-dependent (By similarity)1
  • Ubiquitination2 at Lys65, Lys86, Lys99, Lys101, Lys113
  • Modification sites at PhosphoSitePlus

  • See ANP32E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001129950.1  NP_001129951.1  NP_001267488.1  NP_001267489.1  NP_112182.1  

    ENSEMBL proteins: 
     ENSP00000324074   ENSP00000358115   ENSP00000393718   ENSP00000431434   ENSP00000358110  
     ENSP00000358111   ENSP00000435215   ENSP00000436529   ENSP00000432684   ENSP00000358112  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANP32: ANP32 acidic nuclear phosphoproteins

    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR003603 U2A'_phosphoprotein32A_C

    Graphical View of Domain Structure for InterPro Entry Q9BTT0

    ProtoNet protein and cluster: Q9BTT0

    1 Blocks protein domain: IPB003603 Leucine-rich-associated

    UniProtKB/Swiss-Prot: AN32E_HUMAN, Q9BTT0
    Domain: The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AFZ (PubMed:24463511)
    Similarity: Belongs to the ANP32 family
    Similarity: Contains 4 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain


    Find genes that share domains with ANP32E           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AN32E_HUMAN, Q9BTT0
    Function: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the
    nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator
    regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B
    dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits
    activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar
    development and synaptogenesis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019212phosphatase inhibitor activity ISS--
    GO:0042393histone binding IDA--
         
    Find genes that share ontologies with ANP32E           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ANP32E:
     Altered focal adhesion (FA) or  Increased homologous recombina 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Anp32e):
     behavior/neurological  mortality/aging  normal  reproductive system 

    Find genes that share phenotypes with ANP32E           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Anp32etm1Mak for ANP32E

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANP32E
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANP32E

    miRNA
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    miRTarBase miRNAs that target ANP32E:
    hsa-mir-1 (MIRT024101), hsa-mir-877-3p (MIRT037043), hsa-mir-128-3p (MIRT022086), hsa-let-7b-5p (MIRT032491)

    Block miRNA regulation of human, mouse, rat ANP32E using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANP32E (see all 56):
    hsa-miR-3685 hsa-miR-4272 hsa-miR-200a hsa-miR-25 hsa-miR-650 hsa-miR-548l hsa-miR-502-3p hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidANP32E 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AN32E_HUMAN, Q9BTT0: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000812Swr1 complex IDA--
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ----
    GO:0016023cytoplasmic membrane-bounded vesicle ISS--

    Find genes that share ontologies with ANP32E           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANP32E
    Interactions:

        Search GeneGlobe Interaction Network for ANP32E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANP32E (Q9BTT03 ENSP000003240744) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    DDA1Q9BW613I2D: score=1 
    FOSP011003I2D: score=1 
    GBASO753233I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043086negative regulation of catalytic activity ISS--
    GO:0043486histone exchange IDA--

    Find genes that share ontologies with ANP32E           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANP32E (AN32E)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANP32E gene (5 alternative transcripts): 
    NM_001136478.3  NM_001136479.2  NM_001280559.1  NM_001280560.1  NM_030920.4  

    Unigene Cluster for ANP32E:

    Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
    Hs.656466  [show with all ESTs]
    Unigene Representative Sequence: NM_030920
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314136(uc010pbt.2 uc010pbu.2 uc001etw.3 uc010pbv.2 uc001etv.4 uc010pbw.1)
    ENST00000369119 ENST00000436748 ENST00000534437 ENST00000369114 ENST00000369115
    ENST00000533654 ENST00000534220 ENST00000532744 ENST00000369116
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ANP32E (see all 56):
    hsa-miR-3685 hsa-miR-4272 hsa-miR-200a hsa-miR-25 hsa-miR-650 hsa-miR-548l hsa-miR-502-3p hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidANP32E 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ANP32E
      QuantiFast Probe-based Assays in human, mouse, rat ANP32E

    Additional mRNA sequence: 

    AK025624.1 AK092672.1 AK095228.1 AK223469.1 AK303333.1 AK303392.1 AL832664.1 AL832674.1 
    AL833660.1 AY057381.1 BC003380.1 

    12 DOTS entries:

    DT.441530  DT.100807531  DT.91921549  DT.95163066  DT.100037230  DT.100807528  DT.100807530  DT.121401359 
    DT.121401375  DT.40204756  DT.91758320  DT.91758322 

    Selected AceView cDNA sequences (see all 305):

    AA854203 BQ005201 AW630790 BM974388 AL710865 BP341458 BQ946235 AA932422 
    AA356832 AW504258 AI002036 BQ424786 AA913812 AW169554 AA130596 CK904095 
    AI457959 BE887747 AI185485 AA130595 AW504118 BX415095 CB111429 AW078893 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ANP32E    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                          -     -     -     -     -                     
    SP2:                                                                        
    SP3:              -                                                         
    SP4:                                                                        
    SP5:                    -                                                   


    ECgene alternative splicing isoforms for ANP32E

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANP32E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGTGTTAA
    ANP32E Expression
    About this image


    ANP32E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
    ANP32E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANP32E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656466

    UniProtKB/Swiss-Prot: AN32E_HUMAN, Q9BTT0
    Tissue specificity: Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen,
    skeletal muscle, liver and kidney

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANP32E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANP32E gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anp32e5 acidic (leucine-rich) nuclear phosphoprotein 32 family, more   --   3 (41.59 cM) 95929246 
    chicken
    (Gallus gallus)
    Aves ANP32E6
    Gallus gallus acidic (leucine-rich) nuclear phosph...
    84(a)
    1 ↔ 1
    25(29851-41892)
    lizard
    (Anolis carolinensis)
    Reptilia ANP32E6
    acidic (leucine-rich) nuclear phosphoprotein 32 fa...
    82(a)
    1 ↔ 1
    GL343697.1(230435-241275)
    African clawed frog
    (Xenopus laevis)
    Amphibia anp32e-prov2 leucine-rich acidic nuclear protein like 77.81(n)    BC043985.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056543.12   -- 74.84(n)    BC056543.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mapmodulin6
    Mapmodulin
    33(a)
    1 → many
    2R(13753827-13759515)
    worm
    (Caenorhabditis elegans)
    Secernentea T19H12.26
    F33H2.36
    Protein F33H2.3 (F33H2.3) mRNA, complete cds
    38(a)
    37(a)
    many ↔ many
    many ↔ many
    V(4890429-4891422) WBGene00020588
    I(15034517-15035467) WBGene00009367


    ENSEMBL Gene Tree for ANP32E (if available)
    TreeFam Gene Tree for ANP32E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANP32E gene
    ANP32D2  ANP32A2  ANP32B2  
    4 SIMAP similar genes for ANP32E using alignment to 7 protein entries:     AN32E_HUMAN (see all proteins):
    ANP32A    ANP32D    ANP32B    ANP32C

    Find genes that share paralogs with ANP32E           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANP32E (see all 323)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1496536761,2
    C--150190332(+) CCCAGC/TACTTT 3 -- int10--------
    rs1861455851,2
    --150190539(+) CGCCAC/TTGCAC 3 -- int10--------
    rs1454706121,2
    --150190675(+) AAGCCA/GCTAAT 3 -- int10--------
    rs127435681,2
    C,H--150190803(+) AGGGAA/CCAGTC 3 -- ut31 ese35Minor allele frequency- C:0.00NS EA NA 418
    rs1889893391,2
    --150191137(+) GATGAC/TTGATA 3 -- ut310--------
    rs1814047141,2
    --150191214(+) GAATTA/GTTAGG 3 -- ut310--------
    rs1863217951,2
    --150191326(+) GGTCAC/GTTGTA 3 -- ut310--------
    rs1148116411,2
    C,F--150191364(+) CATCAT/AAATTT 3 -- ut311Minor allele frequency- A:0.06WA 118
    rs1906885811,2
    --150191502(+) AAAACC/TTACAA 3 -- ut310--------
    rs1828167721,2
    --150191531(+) AAAAAA/TTTTAG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ANP32E (150190717 - 150208504 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ANP32E:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271753CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANP32E
    DNA2.0 Custom Variant and Variant Library Synthesis for ANP32E

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609611    OMIM disorders: --


    Find genes that share disorders with ANP32E           About GenesLikeMe


    Export disorders for ANP32E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANP32E gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with ANP32E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain. (PubMed id 12438741)1, 2, 3, 9 Jiang M....Mao Y. (Cytogenet. Genome Res. 2002)
    2. ANP32E is a histone chaperone that removes H2A.Z from chromatin. (PubMed id 24463511)1, 2 Obri A.... Hamiche A. (Nature 2014)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (amp 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (Mol. Cell. Biochem. 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81611 HGNC: 16673 AceView: ANP32E Ensembl:ENSG00000143401 euGenes: HUgn81611
    ECgene: ANP32E H-InvDB: ANP32E

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANP32E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANP32E gene:
    Search GeneIP for patents involving ANP32E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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