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Aliases for ANP32E Gene

Aliases for ANP32E Gene

  • Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member E 2 3
  • LANP-Like Protein 3 4
  • LANP-L 3 4
  • LANPL 3 6
  • Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member E 3
  • Leucine-Rich Acidic Nuclear Protein Like 3

External Ids for ANP32E Gene

Summaries for ANP32E Gene

GeneCards Summary for ANP32E Gene

ANP32E (Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member E) is a Protein Coding gene. GO annotations related to this gene include phosphatase inhibitor activity. An important paralog of this gene is ANP32B.

UniProtKB/Swiss-Prot for ANP32E Gene

  • Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.

Gene Wiki entry for ANP32E Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANP32E Gene

Genomics for ANP32E Gene

Genomic Location for ANP32E Gene

Start:
150,218,417 bp from pter
End:
150,236,156 bp from pter
Size:
17,740 bases
Orientation:
Minus strand

Genomic View for ANP32E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANP32E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANP32E Gene

Regulatory Elements for ANP32E Gene

Proteins for ANP32E Gene

  • Protein details for ANP32E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTT0-AN32E_HUMAN
    Recommended name:
    Acidic leucine-rich nuclear phosphoprotein 32 family member E
    Protein Accession:
    Q9BTT0
    Secondary Accessions:
    • B4E0I6
    • E9PEA6
    • Q5TB18
    • Q5TB20
    • Q8N1S4
    • Q8WWW9

    Protein attributes for ANP32E Gene

    Size:
    268 amino acids
    Molecular mass:
    30692 Da
    Quaternary structure:
    • Interacts with the importin alpha KPNA1 and KPNA2 (By similarity). Component of a SWR1-like complex, composed of EP400, KAT5/TIP60, TRRAP, BRD8, RUVBL1, RUVBL2, ING3 and ANP32E; the complex does not contain SRCAP. Interacts with H2A.Z/H2AFZ.

    Three dimensional structures from OCA and Proteopedia for ANP32E Gene

    Alternative splice isoforms for ANP32E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANP32E Gene

Proteomics data for ANP32E Gene at MOPED

Post-translational modifications for ANP32E Gene

  • Phosphorylated. The phosphorylation is nuclear localization signal (NLS)-dependent (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys65, Lys86, Lys99, Lys101, and Lys113

No data available for DME Specific Peptides for ANP32E Gene

Domains for ANP32E Gene

Gene Families for ANP32E Gene

HGNC:
  • ANP32 :ANP32 acidic nuclear phosphoproteins

Protein Domains for ANP32E Gene

Suggested Antigen Peptide Sequences for ANP32E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTT0

UniProtKB/Swiss-Prot:

AN32E_HUMAN
Domain:
  • The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AFZ.:
    • Q9BTT0
  • Contains 1 LRRCT domain.:
    • Q9BTT0
Family:
  • Belongs to the ANP32 family.:
    • Q9BTT0
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.:
    • Q9BTT0
genes like me logo Genes that share domains with ANP32E: view

Function for ANP32E Gene

Molecular function for ANP32E Gene

UniProtKB/Swiss-Prot Function: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.

Gene Ontology (GO) - Molecular Function for ANP32E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019212 phosphatase inhibitor activity ISS --
GO:0042393 histone binding IDA 24463511
genes like me logo Genes that share ontologies with ANP32E: view
genes like me logo Genes that share phenotypes with ANP32E: view

Animal Models for ANP32E Gene

MGI Knock Outs for ANP32E:

miRNA for ANP32E Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ANP32E Gene

Localization for ANP32E Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANP32E Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANP32E Gene COMPARTMENTS Subcellular localization image for ANP32E gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANP32E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm --
GO:0016023 cytoplasmic membrane-bounded vesicle ISS --
genes like me logo Genes that share ontologies with ANP32E: view

Pathways for ANP32E Gene

SuperPathways for ANP32E Gene

No Data Available

Interacting Proteins for ANP32E Gene

Selected Interacting proteins: Q9BTT0-AN32E_HUMAN for ANP32E Gene via I2D

Gene Ontology (GO) - Biological Process for ANP32E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043086 negative regulation of catalytic activity IEA --
GO:0043486 histone exchange IDA 24463511
genes like me logo Genes that share ontologies with ANP32E: view

No data available for Pathways by source for ANP32E Gene

Transcripts for ANP32E Gene

Unigene Clusters for ANP32E Gene

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANP32E Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5: -

Relevant External Links for ANP32E Gene

GeneLoc Exon Structure for
ANP32E
ECgene alternative splicing isoforms for
ANP32E

Expression for ANP32E Gene

mRNA expression in normal human tissues for ANP32E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ANP32E Gene

SOURCE GeneReport for Unigene cluster for ANP32E Gene Hs.656466

mRNA Expression by UniProt/SwissProt for ANP32E Gene

Q9BTT0-AN32E_HUMAN
Tissue specificity: Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney.
genes like me logo Genes that share expressions with ANP32E: view

No data available for mRNA differential expression in normal tissues for ANP32E Gene

Orthologs for ANP32E Gene

This gene was present in the common ancestor of animals.

Orthologs for ANP32E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANP32E 35
  • 99.5 (n)
  • 100 (a)
ANP32E 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANP32E 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANP32E 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anp32e 16
Anp32e 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANP32E 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANP32E 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANP32E 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANP32E 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia anp32e-prov 35
zebrafish
(Danio rerio)
Actinopterygii anp32e 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mapmodulin 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F33H2.3 36
  • 37 (a)
ManyToMany
T19H12.2 36
  • 38 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11188 36
  • 44 (a)
OneToMany
Species with no ortholog for ANP32E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ANP32E Gene

ENSEMBL:
Gene Tree for ANP32E (if available)
TreeFam:
Gene Tree for ANP32E (if available)

Paralogs for ANP32E Gene

Paralogs for ANP32E Gene

Selected SIMAP similar genes for ANP32E Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ANP32E: view

Variants for ANP32E Gene

Sequence variations from dbSNP and Humsavar for ANP32E Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1924549 -- 150,236,492(+) CCCAA(C/G)TTGCG upstream-variant-2KB
rs2038752 -- 150,234,030(+) AAGTA(C/T)GTAAG intron-variant
rs2038753 -- 150,234,352(+) AAGTT(A/C)TCTCC intron-variant
rs4926392 -- 150,224,529(+) AGATC(A/G)CACCA intron-variant
rs4926414 -- 150,221,258(+) taggg(A/T)aaacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANP32E Gene

Variant ID Type Subtype PubMed ID
esv271753 CNV Insertion 20981092

Relevant External Links for ANP32E Gene

HapMap Linkage Disequilibrium report
ANP32E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANP32E Gene

Disorders for ANP32E Gene

No disorders were found for ANP32E Gene.

No data available for UniProtKB/Swiss-Prot for ANP32E Gene

Publications for ANP32E Gene

  1. Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain. (PMID: 12438741) Jiang M. … Mao Y. (Cytogenet. Genome Res. 2002) 2 3 4 23
  2. ANP32E is a histone chaperone that removes H2A.Z from chromatin. (PMID: 24463511) Obri A. … Hamiche A. (Nature 2014) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for ANP32E Gene

Sources for ANP32E Gene

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