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Aliases for ANP32E Gene

Aliases for ANP32E Gene

  • Acidic Nuclear Phosphoprotein 32 Family Member E 2 3 5
  • Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member E 2 3
  • LANP-Like Protein 3 4
  • LANP-L 3 4
  • Leucine-Rich Acidic Nuclear Protein Like 3
  • LANPL 3

External Ids for ANP32E Gene

Previous GeneCards Identifiers for ANP32E Gene

  • GC01M146965
  • GC01M147407
  • GC01M147003
  • GC01M148457
  • GC01M121570

Summaries for ANP32E Gene

GeneCards Summary for ANP32E Gene

ANP32E (Acidic Nuclear Phosphoprotein 32 Family Member E) is a Protein Coding gene. GO annotations related to this gene include histone binding and phosphatase inhibitor activity. An important paralog of this gene is ANP32B.

UniProtKB/Swiss-Prot for ANP32E Gene

  • Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.

Gene Wiki entry for ANP32E Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANP32E Gene

Genomics for ANP32E Gene

Regulatory Elements for ANP32E Gene

Promoters for ANP32E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANP32E on UCSC Golden Path with GeneCards custom track

Genomic Location for ANP32E Gene

Chromosome:
1
Start:
150,218,417 bp from pter
End:
150,236,156 bp from pter
Size:
17,740 bases
Orientation:
Minus strand

Genomic View for ANP32E Gene

Genes around ANP32E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANP32E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANP32E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANP32E Gene

Proteins for ANP32E Gene

  • Protein details for ANP32E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTT0-AN32E_HUMAN
    Recommended name:
    Acidic leucine-rich nuclear phosphoprotein 32 family member E
    Protein Accession:
    Q9BTT0
    Secondary Accessions:
    • B4E0I6
    • E9PEA6
    • Q5TB18
    • Q5TB20
    • Q8N1S4
    • Q8WWW9

    Protein attributes for ANP32E Gene

    Size:
    268 amino acids
    Molecular mass:
    30692 Da
    Quaternary structure:
    • Interacts with the importin alpha KPNA1 and KPNA2 (By similarity). Component of a SWR1-like complex, composed of EP400, KAT5/TIP60, TRRAP, BRD8, RUVBL1, RUVBL2, ING3 and ANP32E; the complex does not contain SRCAP. Interacts with H2A.Z/H2AFZ.

    Three dimensional structures from OCA and Proteopedia for ANP32E Gene

    Alternative splice isoforms for ANP32E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANP32E Gene

Proteomics data for ANP32E Gene at MOPED

Post-translational modifications for ANP32E Gene

  • Phosphorylated. The phosphorylation is nuclear localization signal (NLS)-dependent (By similarity).
  • Ubiquitination at Lys 65, Lys 86, Lys 99, Lys 101, and Lys 113
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ANP32E Gene

Domains & Families for ANP32E Gene

Gene Families for ANP32E Gene

Protein Domains for ANP32E Gene

Suggested Antigen Peptide Sequences for ANP32E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTT0

UniProtKB/Swiss-Prot:

AN32E_HUMAN :
  • The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AFZ.
  • Belongs to the ANP32 family.
  • Contains 4 LRR (leucine-rich) repeats.
Domain:
  • The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AFZ.
  • Contains 1 LRRCT domain.
Family:
  • Belongs to the ANP32 family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ANP32E: view

Function for ANP32E Gene

Molecular function for ANP32E Gene

UniProtKB/Swiss-Prot Function:
Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.

Gene Ontology (GO) - Molecular Function for ANP32E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019212 phosphatase inhibitor activity ISS --
genes like me logo Genes that share ontologies with ANP32E: view
genes like me logo Genes that share phenotypes with ANP32E: view

Animal Model Products

CRISPR Products

miRNA for ANP32E Gene

miRTarBase miRNAs that target ANP32E

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANP32E Gene

Localization for ANP32E Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANP32E Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANP32E Gene COMPARTMENTS Subcellular localization image for ANP32E gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for ANP32E Gene

Pathways & Interactions for ANP32E Gene

SuperPathways for ANP32E Gene

No Data Available

Interacting Proteins for ANP32E Gene

Selected Interacting proteins: Q9BTT0-AN32E_HUMAN for ANP32E Gene via I2D

Gene Ontology (GO) - Biological Process for ANP32E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with ANP32E: view

No data available for Pathways by source and SIGNOR curated interactions for ANP32E Gene

Drugs & Compounds for ANP32E Gene

No Compound Related Data Available

Transcripts for ANP32E Gene

Unigene Clusters for ANP32E Gene

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANP32E Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5: -

Relevant External Links for ANP32E Gene

GeneLoc Exon Structure for
ANP32E
ECgene alternative splicing isoforms for
ANP32E

Expression for ANP32E Gene

mRNA expression in normal human tissues for ANP32E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANP32E Gene

This gene is overexpressed in Lymph node (8.8) and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ANP32E Gene



SOURCE GeneReport for Unigene cluster for ANP32E Gene Hs.656466

mRNA Expression by UniProt/SwissProt for ANP32E Gene

Q9BTT0-AN32E_HUMAN
Tissue specificity: Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney.
genes like me logo Genes that share expression patterns with ANP32E: view

Protein tissue co-expression partners for ANP32E Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ANP32E Gene

Orthologs for ANP32E Gene

This gene was present in the common ancestor of animals.

Orthologs for ANP32E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANP32E 35
  • 99.5 (n)
  • 100 (a)
ANP32E 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANP32E 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANP32E 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANP32E 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anp32e 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANP32E 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANP32E 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANP32E 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia anp32e-prov 35
zebrafish
(Danio rerio)
Actinopterygii anp32e 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mapmodulin 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F33H2.3 36
  • 37 (a)
ManyToMany
T19H12.2 36
  • 38 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11188 36
  • 44 (a)
OneToMany
Species with no ortholog for ANP32E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ANP32E Gene

ENSEMBL:
Gene Tree for ANP32E (if available)
TreeFam:
Gene Tree for ANP32E (if available)

Paralogs for ANP32E Gene

Paralogs for ANP32E Gene

(4) SIMAP similar genes for ANP32E Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ANP32E: view

Variants for ANP32E Gene

Sequence variations from dbSNP and Humsavar for ANP32E Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1924549 -- 150,236,492(+) CCCAA(C/G)TTGCG upstream-variant-2KB
rs2038752 -- 150,234,030(+) AAGTA(C/T)GTAAG intron-variant
rs2038753 -- 150,234,352(+) AAGTT(A/C)TCTCC intron-variant
rs4926392 -- 150,224,529(+) AGATC(A/G)CACCA intron-variant
rs6682434 -- 150,221,069(+) aagat(C/G/T)gcgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANP32E Gene

Variant ID Type Subtype PubMed ID
esv271753 CNV Insertion 20981092

Variation tolerance for ANP32E Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.84; 93.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANP32E Gene

HapMap Linkage Disequilibrium report
ANP32E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANP32E Gene

Disorders for ANP32E Gene

Relevant External Links for ANP32E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANP32E

No disorders were found for ANP32E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANP32E Gene

Publications for ANP32E Gene

  1. Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain. (PMID: 12438741) Jiang M. … Mao Y. (Cytogenet. Genome Res. 2002) 2 3 4 23 67
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. ANP32E is a histone chaperone that removes H2A.Z from chromatin. (PMID: 24463511) Obri A. … Hamiche A. (Nature 2014) 3

Products for ANP32E Gene

Sources for ANP32E Gene

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