Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANP32D Gene

Aliases for ANP32D Gene

  • Acidic Nuclear Phosphoprotein 32 Family Member D 2 3 5
  • Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member D 2 3
  • Phosphoprotein 32-Related Protein 2 3 4
  • Tumorigenic Protein Pp32r2 3 4
  • Pp32 Related 2 2 3
  • PP32R2 3 4
  • Acidic Nuclear Phosphoprotein 32D 3

External Ids for ANP32D Gene

Previous GeneCards Identifiers for ANP32D Gene

  • GC12P048832
  • GC12P048765
  • GC12P048583
  • GC12P047152
  • GC12P045900
  • GC12P048866

Summaries for ANP32D Gene

Entrez Gene Summary for ANP32D Gene

  • Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANP32D Gene

ANP32D (Acidic Nuclear Phosphoprotein 32 Family Member D) is a Protein Coding gene. Diseases associated with ANP32D include chronic mountain sickness. An important paralog of this gene is ANP32B.

Gene Wiki entry for ANP32D Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANP32D Gene

Genomics for ANP32D Gene

Regulatory Elements for ANP32D Gene

Genomic Location for ANP32D Gene

Chromosome:
12
Start:
48,472,665 bp from pter
End:
48,473,624 bp from pter
Size:
960 bases
Orientation:
Plus strand

Genomic View for ANP32D Gene

Genes around ANP32D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANP32D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANP32D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANP32D Gene

Proteins for ANP32D Gene

  • Protein details for ANP32D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95626-AN32D_HUMAN
    Recommended name:
    Acidic leucine-rich nuclear phosphoprotein 32 family member D
    Protein Accession:
    O95626
    Secondary Accessions:
    • Q6NTC4

    Protein attributes for ANP32D Gene

    Size:
    131 amino acids
    Molecular mass:
    14806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANP32D Gene

Proteomics data for ANP32D Gene at MOPED

Post-translational modifications for ANP32D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANP32D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANP32D Gene

Domains & Families for ANP32D Gene

Gene Families for ANP32D Gene

Protein Domains for ANP32D Gene

Suggested Antigen Peptide Sequences for ANP32D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95626

UniProtKB/Swiss-Prot:

AN32D_HUMAN :
  • Belongs to the ANP32 family.
  • Contains 5 LRR (leucine-rich) repeats.
Family:
  • Belongs to the ANP32 family.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ANP32D: view

Function for ANP32D Gene

genes like me logo Genes that share phenotypes with ANP32D: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANP32D Gene

Localization for ANP32D Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANP32D Gene COMPARTMENTS Subcellular localization image for ANP32D gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANP32D Gene

Pathways & Interactions for ANP32D Gene

SuperPathways for ANP32D Gene

No Data Available

Interacting Proteins for ANP32D Gene

Gene Ontology (GO) - Biological Process for ANP32D Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANP32D Gene

Drugs & Compounds for ANP32D Gene

No Compound Related Data Available

Transcripts for ANP32D Gene

mRNA/cDNA for ANP32D Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ANP32D Gene

No ASD Table

Relevant External Links for ANP32D Gene

GeneLoc Exon Structure for
ANP32D
ECgene alternative splicing isoforms for
ANP32D

Expression for ANP32D Gene

mRNA expression in normal human tissues for ANP32D Gene

SOURCE GeneReport for Unigene cluster for ANP32D Gene Hs.532658

genes like me logo Genes that share expression patterns with ANP32D: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ANP32D Gene

Orthologs for ANP32D Gene

This gene was present in the common ancestor of animals.

Orthologs for ANP32D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANP32A 36
  • 45 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 35 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Anp32a 36
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 77 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii anp32a 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mapmodulin 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F33H2.3 36
  • 21 (a)
ManyToMany
T19H12.2 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11188 36
  • 23 (a)
OneToMany
Species with no ortholog for ANP32D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ANP32D Gene

ENSEMBL:
Gene Tree for ANP32D (if available)
TreeFam:
Gene Tree for ANP32D (if available)

Paralogs for ANP32D Gene

Paralogs for ANP32D Gene

(4) SIMAP similar genes for ANP32D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANP32D: view

Variants for ANP32D Gene

Sequence variations from dbSNP and Humsavar for ANP32D Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_027832 -

Variation tolerance for ANP32D Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANP32D Gene

HapMap Linkage Disequilibrium report
ANP32D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANP32D Gene

Disorders for ANP32D Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANP32D Gene - From: GeneCards

Disorder Aliases PubMed IDs
chronic mountain sickness
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANP32D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANP32D
genes like me logo Genes that share disorders with ANP32D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANP32D Gene

Publications for ANP32D Gene

  1. Modulation of oncogenic potential by alternative gene use in human prostate cancer. (PMID: 10086381) Kadkol S.S. … Pasternack G.R. (Nat. Med. 1999) 2 3 4 23 67
  2. Identification of sequences required for inhibition of oncogene- mediated transformation by pp32. (PMID: 10400610) Brody J.R. … Pasternack G.R. (J. Biol. Chem. 1999) 2 3
  3. Genetic variation in SENP1 and ANP32D as predictors of chronic mountain sickness. (PMID: 25225945) Cole A.M. … Robbins P.A. (High Alt. Med. Biol. 2014) 3
  4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3
  5. The Anp32 family of proteins containing leucine-rich repeats. (PMID: 15895553) Matilla A. … Radrizzani M. (Cerebellum 2005) 3

Products for ANP32D Gene

Sources for ANP32D Gene

Back to Top

Content