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Aliases for ANP32C Gene

Aliases for ANP32C Gene

  • Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member C 2 3
  • PP32R1 3 4 6
  • Phosphoprotein 32-Related Protein 1 3 4
  • Tumorigenic Protein Pp32r1 3 4
  • Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member C 3
  • Pp32 Related 1 3

External Ids for ANP32C Gene

Previous GeneCards Identifiers for ANP32C Gene

  • GC04M165967
  • GC04M165546
  • GC04M165695
  • GC04M165475
  • GC04M165337
  • GC04M165118
  • GC04M160872

Summaries for ANP32C Gene

Entrez Gene Summary for ANP32C Gene

  • Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANP32C Gene

ANP32C (Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member C) is a Protein Coding gene. Diseases associated with ANP32C include hiv-1.

Gene Wiki entry for ANP32C Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANP32C Gene

Genomics for ANP32C Gene

Regulatory Elements for ANP32C Gene

Genomic Location for ANP32C Gene

Start:
164,197,007 bp from pter
End:
164,197,711 bp from pter
Size:
705 bases
Orientation:
Minus strand

Genomic View for ANP32C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANP32C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANP32C Gene

Proteins for ANP32C Gene

  • Protein details for ANP32C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43423-AN32C_HUMAN
    Recommended name:
    Acidic leucine-rich nuclear phosphoprotein 32 family member C
    Protein Accession:
    O43423
    Secondary Accessions:
    • Q4W5F9

    Protein attributes for ANP32C Gene

    Size:
    234 amino acids
    Molecular mass:
    26762 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANP32C Gene

Proteomics data for ANP32C Gene at MOPED

Post-translational modifications for ANP32C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANP32C Gene

REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ANP32C

No data available for DME Specific Peptides for ANP32C Gene

Domains for ANP32C Gene

Gene Families for ANP32C Gene

HGNC:
  • ANP32 :ANP32 acidic nuclear phosphoproteins

Protein Domains for ANP32C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANP32C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43423

UniProtKB/Swiss-Prot:

AN32C_HUMAN :
  • O43423
Family:
  • Belongs to the ANP32 family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ANP32C: view

Function for ANP32C Gene

miRNA for ANP32C Gene

miRTarBase miRNAs that target ANP32C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANP32C

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANP32C Gene

Localization for ANP32C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANP32C Gene COMPARTMENTS Subcellular localization image for ANP32C gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANP32C Gene

Pathways for ANP32C Gene

SuperPathways for ANP32C Gene

No Data Available

Interacting Proteins for ANP32C Gene

Selected Interacting proteins: O43423-AN32C_HUMAN for ANP32C Gene via I2D

Gene Ontology (GO) - Biological Process for ANP32C Gene

None

No data available for Pathways by source for ANP32C Gene

Transcripts for ANP32C Gene

mRNA/cDNA for ANP32C Gene

(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANP32C Gene

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member C:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANP32C

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANP32C Gene

No ASD Table

Relevant External Links for ANP32C Gene

GeneLoc Exon Structure for
ANP32C
ECgene alternative splicing isoforms for
ANP32C

Expression for ANP32C Gene

mRNA expression in normal human tissues for ANP32C Gene

Protein differential expression in normal tissues for ANP32C Gene

This gene is overexpressed in Heart (59.2) and Brain (9.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ANP32C Gene

SOURCE GeneReport for Unigene cluster for ANP32C Gene Hs.661161

mRNA Expression by UniProt/SwissProt for ANP32C Gene

O43423-AN32C_HUMAN
Tissue specificity: Expressed in activated stem cells, such as mobilized CD34+ cells and cord blood CD34+ cells, but not in resting bone marrow CD34+ cells. Expressed in a variety of neoplastic cell lines, mainly in prostatic adenocarcinoma cell lines. Not expressed in normal prostatic tissue.
genes like me logo Genes that share expressions with ANP32C: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ANP32C Gene

Orthologs for ANP32C Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for ANP32C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANP32C 35
  • 97.29 (n)
  • 93.59 (a)
mouse
(Mus musculus)
Mammalia Anp32-ps 16
Species with no ortholog for ANP32C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANP32C Gene

ENSEMBL:
Gene Tree for ANP32C (if available)
TreeFam:
Gene Tree for ANP32C (if available)

Paralogs for ANP32C Gene

Selected SIMAP similar genes for ANP32C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANP32C: view

No data available for Paralogs for ANP32C Gene

Variants for ANP32C Gene

Sequence variations from dbSNP and Humsavar for ANP32C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_020419 -
VAR_020420 -
VAR_026702 -
VAR_026703 -
VAR_048314 -

Relevant External Links for ANP32C Gene

HapMap Linkage Disequilibrium report
ANP32C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANP32C Gene

Disorders for ANP32C Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ANP32C Gene in MalaCards »

(1) Diseases for ANP32C Gene including...

Relevant External Links for ANP32C

Genetic Association Database (GAD)
ANP32C
genes like me logo Genes that share disorders with ANP32C: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ANP32C Gene

Publications for ANP32C Gene

  1. Modulation of oncogenic potential by alternative gene use in human prostate cancer. (PMID: 10086381) Kadkol S.S. … Pasternack G.R. (Nat. Med. 1999) 2 3 4 23
  2. Identification of a functional mutation in pp32r1 (ANP32C). (PMID: 15146458) Kochevar G.J. … Pasternack G.R. (Hum. Mutat. 2004) 3 4 23
  3. Identification of sequences required for inhibition of oncogene- mediated transformation by pp32. (PMID: 10400610) Brody J.R. … Pasternack G.R. (J. Biol. Chem. 1999) 2 3
  4. Correction to "Modulation of oncogenic potential by alternative gene use in human prostate cancer" (PMID: 10471270) Kadkol S.S. … Pasternack G.R. (Nat. Med. 1999) 3 4
  5. The Anp32 family of proteins containing leucine-rich repeats. (PMID: 15895553) Matilla A. … Radrizzani M. (Cerebellum 2005) 3 4

Products for ANP32C Gene

Sources for ANP32C Gene

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