ANP32C Gene
pseudogene GIFtS: 39
GCID: GC04M165118
|
|
acidic (leucine-rich) nuclear phosphoprotein 32 family,...
| |
Aliases
for ANP32C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member C1 2 | | PP32R11 2 3 5 | | Phosphoprotein 32-Related Protein 12 3 | | Tumorigenic Protein Pp32r12 3 | | Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member C2 | | Pp32 Related 12 |
Export aliases for ANP32C gene to outside databasesPrevious GC identifers: GC04M165967 GC04M165546 GC04M165695 GC04M165475 GC04M165337 GC04M160872 |
Summaries
for ANP32C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ANP32C:
Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breastcancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence toPP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein istumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergentbetween PP32 and the protein encoded by this gene. This gene does not contain introns. (provided by RefSeq, Jul 2008)
Gene Wiki entry for ANP32C
|
Genomic Views
for ANP32C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANP32C gene promoter:
TBP NF-1 NF-1/L LHX3b/Lhx3b Pax-2 Pax-2a Nkx2-5 HSF2 LHX3a/Lhx3a Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANP32C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANP32C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q32.3 Ensembl cytogenetic band: 4q32.3 HGNC cytogenetic band: 4q32.3ANP32C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M165118: view genomic region
(about GC identifiers)
Start:
|
165,118,159 bp from pter |
End:
|
165,118,863 bp from pter |
Size:
|
705 bases |
Orientation:
|
minus strand |
|
Proteins
for ANP32C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AN32C_HUMAN, O43423 (See
protein sequence)Recommended Name: Acidic leucine-rich nuclear phosphoprotein 32 family member C Size: 234 amino acids; 26762 Da
Caution: The His-140 polymorphism is uncertain. It has been found in prostatic cell line without corresponding normaltissue sample. Cells transfected with this variant expressed at least twice as much proteins than native cells
Secondary accessions: Q4W5F9Explore the universe of human proteins at neXtProt for ANP32C: NX_O43423
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43423
ANP32C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036535.1
Human Recombinant Protein Products:
ANP32C Antibody Products:
Assay Products for ANP32C: |
Protein
Domains /
Families
for ANP32C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANP32C for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43423ProtoNet protein and cluster: O43423 UniProtKB/Swiss-Prot: AN32C_HUMAN, O43423Similarity: Belongs to the ANP32 familySimilarity: Contains 4 LRR (leucine-rich) repeats |
Function
for ANP32C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANP32C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANP32C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ANP32C (NM_012403) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANP32C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANP32C |
|
Pathways & Interactions
for ANP32C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANP32C
3 Interacting proteins for ANP32C (O434233) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ANP32C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANP32C
Search CenterWatch for drugs/clinical trials and news about ANP32C
|
Transcripts
for ANP32C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANP32C gene: NM_012403.1 Unigene Cluster for ANP32C: Acidic (leucine-rich) nuclear phosphoprotein 32 family, member C Hs.661161 [show with all ESTs]Unigene Representative Sequence: BE7427491 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000512835(uc011cjk.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANP32C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANP32C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANP32C (NM_012403) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANP32C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANP32C |
2 DOTS entries: DT.452718 DT.92064181 1 AceView cDNA sequence: NM_012403
GeneLoc Exon Structure
|
Expression
for ANP32C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANP32C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGAGGAGTA
About this image
See ANP32C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANP32C
SOURCE GeneReport for Unigene cluster: Hs.661161
UniProtKB/Swiss-Prot: AN32C_HUMAN, O43423Tissue specificity: Expressed in activated stem cells, such as mobilized CD34+ cells and cord blood CD34+ cells, butnot in resting bone marrow CD34+ cells. Expressed in a variety of neoplastic cell lines, mainly in prostaticadenocarcinoma cell lines. Not expressed in normal prostatic tissue
SABiosciences Custom PCR Arrays for ANP32C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANP32C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ANP32C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANP32C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANP32C |
Orthologs
for ANP32C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for ANP32C gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Anp32-ps5 |
acidic (leucine-rich) nuclear phosphoprotein 32 family, more |
-- |
|
11 (19.21 cM) 33394879 |
ENSEMBL Gene Tree for ANP32C (if available)
TreeFam Gene Tree for ANP32C (if available) |
Paralogs
for ANP32C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ANP32C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ANP32C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANP32C for disorders About GeneDecksing
OMIM gene information: 606877
OMIM disorders: --
5  diseases for ANP32C: About MalaCardsbreast cancer prostatitis prostate adenocarcinoma adenocarcinoma
prostate cancer
Export disorders for ANP32C gene to outside databases
|
Publications
for ANP32C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANP32C gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANP32C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Modulation of oncogenic potential by alternative gene use in human prostate cancer. (PubMed id 10086381)1, 2, 3, 9 Kadkol S.S.... Pasternack G.R. (1999)
- Identification of a functional mutation in pp32r1 (ANP32C). (PubMed id 15146458)1, 2, 9 Kochevar G.J.... Pasternack G.R. (2004)
- The Anp32 family of proteins containing leucine-rich repeats. (PubMed id 15895553)1, 2 Matilla A. and Radrizzani M. (2005)
- Identification of sequences required for inhibition of oncogene- mediated transformation by pp32. (PubMed id 10400610)1, 3 Brody J.R.... Pasternack G.R. (1999)
- Correction to 'Modulation of oncogenic potential by alternative gene use in human prostate cancer' (PubMed id 10471270)1, 2 Kadkol S.S....Pasternack G.R. (1999)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. (PubMed id 12524539)1 Fan Z.... Lieberman J. (2003)
- Tumor suppression and potentiation by manipulation of pp32 expression. (PubMed id 11360199)1 Bai J.... Pasternack G.R. (2001)
- Expression of pp32 gene family members in breast cancer. (PubMed id 11678310)1 Kadkol S.S....Pasternack G.R. (2001)
|
External Searches for ANP32C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANP32C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANP32C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANP32C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ANP32C gene:
Search GeneIP for patents involving ANP32C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANP32C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ANP32C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANP32C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANP32C | | | OriGene Protein Over-expression Lysate for ANP32C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ANP32C | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANP32C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANP32C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ANP32C | | OriGene Custom Protein Services for ANP32C | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANP32C | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANP32C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANP32C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANP32C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANP32C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANP32C |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ANP32C |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ANP32C Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for ANP32C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANP32C |
|
|
|
|
