Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANP32B Gene

Aliases for ANP32B Gene

  • Acidic Nuclear Phosphoprotein 32 Family Member B 2 3 5
  • Acidic Protein Rich In Leucines 2 3 4
  • Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member B 2 3
  • Putative HLA-DR-Associated Protein I-2 3 4
  • Silver-Stainable Protein SSP29 3 4
  • PHAPI2 3 4
  • APRIL 3 4
  • Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B 3
  • SSP29 3

External Ids for ANP32B Gene

Previous GeneCards Identifiers for ANP32B Gene

  • GC09P091570
  • GC09P092489
  • GC09P094202
  • GC09P096125
  • GC09P097825
  • GC09P099785
  • GC09P100745

Summaries for ANP32B Gene

GeneCards Summary for ANP32B Gene

ANP32B (Acidic Nuclear Phosphoprotein 32 Family Member B) is a Protein Coding gene. GO annotations related to this gene include histone binding and RNA polymerase binding. An important paralog of this gene is ANP32A.

UniProtKB/Swiss-Prot for ANP32B Gene

  • Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.

Gene Wiki entry for ANP32B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANP32B Gene

Genomics for ANP32B Gene

Regulatory Elements for ANP32B Gene

Enhancers for ANP32B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F097918 1.5 FANTOM5 ENCODE 12.7 -62.0 -61970 5.9 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC TBX21 NCBP1 ZNF322P1 TRMO LOC105376165 XPA LOC286359 TCEA1P1 LOC100288125 ANP32B LOC101928408
GH09F097932 1.3 Ensembl ENCODE 12.1 -44.5 -44513 11.6 HDGF PKNOX1 ATF1 ARNT CREB3L1 ELK1 GATA2 MCM5 NCOA1 REST TRMO ANP32B LOC101928408 ANKS6 FOXE1 HEMGN
GH09F098044 1.2 Ensembl ENCODE 11.6 +63.2 63231 3.5 HDGF PKNOX1 ATF1 ARID4B DMAP1 ELK1 GATA2 CBX5 NFYC CREB3 NANS LOC101928408 ANP32B TBC1D2 TRIM14 COL15A1 RNU6-918P
GH09F098034 1.1 Ensembl ENCODE 12 +53.0 53039 3.5 ARID4B RAD21 ZNF121 ZNF143 FOS CREM EGR2 ZNF263 ZNF654 HCFC1 NANS TRMO LOC101928408 ANP32B ENSG00000201830 TBC1D2 TSTD2 RNU6-918P
GH09F097958 0.8 ENCODE 12.7 -24.1 -24089 1.0 HDAC1 DDX20 NFRKB ETV1 ZNF175 RELA ZNF316 FOS NFE2 MAFK ANP32B LOC101928408 TRMO GC09P097960 PIR49291 HEMGN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANP32B on UCSC Golden Path with GeneCards custom track

Promoters for ANP32B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001309583 793 3601 HDGF CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 ZNF143

Genomic Location for ANP32B Gene

Chromosome:
9
Start:
97,983,207 bp from pter
End:
98,015,943 bp from pter
Size:
32,737 bases
Orientation:
Plus strand

Genomic View for ANP32B Gene

Genes around ANP32B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANP32B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANP32B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANP32B Gene

Proteins for ANP32B Gene

  • Protein details for ANP32B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92688-AN32B_HUMAN
    Recommended name:
    Acidic leucine-rich nuclear phosphoprotein 32 family member B
    Protein Accession:
    Q92688
    Secondary Accessions:
    • B2R9C7
    • O00655
    • P78458
    • P78459

    Protein attributes for ANP32B Gene

    Size:
    251 amino acids
    Molecular mass:
    28788 Da
    Quaternary structure:
    • Monomer. Interacts with histones H3 and H4.

    Three dimensional structures from OCA and Proteopedia for ANP32B Gene

    Alternative splice isoforms for ANP32B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANP32B Gene

Post-translational modifications for ANP32B Gene

  • Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).
  • Ubiquitination at Lys 86 and Lys 99
  • Modification sites at PhosphoSitePlus

Other Protein References for ANP32B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANP32B Gene

Domains & Families for ANP32B Gene

Gene Families for ANP32B Gene

Protein Domains for ANP32B Gene

Suggested Antigen Peptide Sequences for ANP32B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92688

UniProtKB/Swiss-Prot:

AN32B_HUMAN :
  • Histone binding is mediated by the concave surface of the LRR region.
  • Belongs to the ANP32 family.
  • Contains 4 LRR (leucine-rich) repeats.
Domain:
  • Histone binding is mediated by the concave surface of the LRR region.
  • Contains 1 LRRCT domain.
Family:
  • Belongs to the ANP32 family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ANP32B: view

Function for ANP32B Gene

Molecular function for ANP32B Gene

UniProtKB/Swiss-Prot Function:
Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.

Gene Ontology (GO) - Molecular Function for ANP32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
GO:0042393 histone binding IDA 20538007
GO:0070063 RNA polymerase binding IDA 9285060
genes like me logo Genes that share ontologies with ANP32B: view
genes like me logo Genes that share phenotypes with ANP32B: view

Animal Model Products

miRNA for ANP32B Gene

miRTarBase miRNAs that target ANP32B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANP32B Gene

Localization for ANP32B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANP32B Gene

Isoform 1: Nucleus. Note=Accumulates in the nuclei at the S phase. {ECO:0000250}.
Isoform 2: Cytoplasm. Note=Lacks a nuclear localization signal.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANP32B gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANP32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9285060
GO:0005730 colocalizes_with nucleolus IDA 9285060
GO:0005737 cytoplasm IEA,IDA 17178712
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with ANP32B: view

Pathways & Interactions for ANP32B Gene

SuperPathways for ANP32B Gene

No Data Available

SIGNOR curated interactions for ANP32B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ANP32B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001944 vasculature development IEA --
GO:0006334 nucleosome assembly IDA 20538007
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP 20015864
GO:0021591 ventricular system development IEA --
GO:0043486 histone exchange IBA --
genes like me logo Genes that share ontologies with ANP32B: view

No data available for Pathways by source for ANP32B Gene

Transcripts for ANP32B Gene

mRNA/cDNA for ANP32B Gene

Unigene Clusters for ANP32B Gene

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANP32B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: -
SP3:

Relevant External Links for ANP32B Gene

GeneLoc Exon Structure for
ANP32B
ECgene alternative splicing isoforms for
ANP32B

Expression for ANP32B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANP32B Gene

Protein differential expression in normal tissues from HIPED for ANP32B Gene

This gene is overexpressed in Lymph node (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANP32B Gene



Protein tissue co-expression partners for ANP32B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANP32B Gene:

ANP32B

SOURCE GeneReport for Unigene cluster for ANP32B Gene:

Hs.730654

mRNA Expression by UniProt/SwissProt for ANP32B Gene:

Q92688-AN32B_HUMAN
Tissue specificity: Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.
genes like me logo Genes that share expression patterns with ANP32B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ANP32B Gene

Orthologs for ANP32B Gene

This gene was present in the common ancestor of animals.

Orthologs for ANP32B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANP32B 34 35
  • 99.87 (n)
cow
(Bos Taurus)
Mammalia ANP32B 34 35
  • 94.17 (n)
dog
(Canis familiaris)
Mammalia ANP32B 34 35
  • 84.27 (n)
oppossum
(Monodelphis domestica)
Mammalia ANP32B 35
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anp32b 35
  • 80 (a)
OneToMany
Gm5263 35
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ANP32B 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANP32B 35
  • 60 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ANP32B 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anp32b 34
  • 78.54 (n)
Str.20236 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6758 34
zebrafish
(Danio rerio)
Actinopterygii anp32b 34 35
  • 77.92 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5197 34
fruit fly
(Drosophila melanogaster)
Insecta Mapmodulin 36 35
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea F33H2.3 35
  • 35 (a)
ManyToMany
T19H12.2 35
  • 32 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11188 35
  • 43 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12721 34
Species where no ortholog for ANP32B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANP32B Gene

ENSEMBL:
Gene Tree for ANP32B (if available)
TreeFam:
Gene Tree for ANP32B (if available)

Paralogs for ANP32B Gene

Paralogs for ANP32B Gene

(4) SIMAP similar genes for ANP32B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ANP32B Gene

genes like me logo Genes that share paralogs with ANP32B: view

Variants for ANP32B Gene

Sequence variations from dbSNP and Humsavar for ANP32B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1010777 -- 98,005,578(-) GCGCA(C/T)GCACA intron-variant
rs10124522 -- 97,997,829(+) ACTCT(A/G)AGATT intron-variant
rs10283632 -- 98,006,478(+) catga(A/G)taaaa intron-variant
rs10709205 -- 98,010,263(+) TGGTG(-/T)TTTTT intron-variant
rs10984626 -- 97,982,312(+) AGATT(C/G)TATTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ANP32B Gene

Variant ID Type Subtype PubMed ID
nsv416479 CNV deletion 16902084
nsv1153519 CNV deletion 26484159
nsv1137664 CNV deletion 24896259
nsv1077165 CNV deletion 25765185
nsv1075258 CNV deletion 25765185
esv7209 CNV loss 19470904
esv4458 CNV loss 18987735
esv2738816 CNV deletion 23290073
esv2540773 CNV deletion 19546169
esv1721459 CNV deletion 17803354
esv1007178 CNV deletion 20482838
dgv491e215 CNV deletion 23714750
dgv4102n106 CNV deletion 24896259

Variation tolerance for ANP32B Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANP32B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANP32B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANP32B Gene

Disorders for ANP32B Gene

Relevant External Links for ANP32B

Genetic Association Database (GAD)
ANP32B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANP32B

No disorders were found for ANP32B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANP32B Gene

Publications for ANP32B Gene

  1. Expression analysis and chromosomal mapping of a novel human gene, APRIL, encoding an acidic protein rich in leucines. (PMID: 9473664) Mencinger M. … Aman P. (Biochim. Biophys. Acta 1998) 2 3 4 22 64
  2. Cloning and characterization of a new silver-stainable protein SSP29, a member of the LRR family. (PMID: 9285060) Zhu L. … Valdez B.C. (Biochem. Mol. Biol. Int. 1997) 2 3 22 64
  3. Solution structure of histone chaperone ANP32B: interaction with core histones H3-H4 through its acidic concave domain. (PMID: 20538007) Tochio N. … Yokoyama S. (J. Mol. Biol. 2010) 3 4 64
  4. Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression. (PMID: 19130553) Chemnitz J. … Hauber J. (Eur. J. Immunol. 2009) 3 22 64
  5. Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression. (PMID: 17178712) Fries B. … Chemnitz J. (J. Biol. Chem. 2007) 3 22 64

Products for ANP32B Gene

Sources for ANP32B Gene

Content
Loading form....