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Aliases for ANP32A Gene

Aliases for ANP32A Gene

  • Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member A 2 3
  • Potent Heat-Stable Protein Phosphatase 2A Inhibitor I1PP2A 3 4
  • Putative HLA-DR-Associated Protein I 3 4
  • Leucine-Rich Acidic Nuclear Protein 3 4
  • Acidic Nuclear Phosphoprotein Pp32 3 4
  • Mapmodulin 3 4
  • C15orf1 3 4
  • PHAP1 3 4
  • PHAPI 3 4
  • PP32 3 4
  • LANP 3 4
  • MAPM 3 4
  • Putative Human HLA Class II Associated Protein I 3
  • Cerebellar Leucine Rich Acidic Nuclear Protein 3
  • Inhibitor-1 Of Protein Phosphatase-2A 3
  • Hepatopoietin Cn 3
  • I1PP2A 3
  • HPPCn 3

External Ids for ANP32A Gene

Previous HGNC Symbols for ANP32A Gene

  • C15orf1

Previous GeneCards Identifiers for ANP32A Gene

  • GC15M064912
  • GC15M062169
  • GC15M066650
  • GC15M066788
  • GC15M066859
  • GC15M066845
  • GC15M069070
  • GC15M045904

Summaries for ANP32A Gene

GeneCards Summary for ANP32A Gene

ANP32A (Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member A) is a Protein Coding gene. Diseases associated with ANP32A include spinocerebellar ataxia 1. Among its related pathways are Gene Expression and Granzyme Pathway. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is ANP32B.

UniProtKB/Swiss-Prot for ANP32A Gene

  • Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.

Gene Wiki entry for ANP32A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANP32A Gene

Genomics for ANP32A Gene

Regulatory Elements for ANP32A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANP32A Gene

Chromosome:
15
Start:
68,778,535 bp from pter
End:
68,820,922 bp from pter
Size:
42,388 bases
Orientation:
Minus strand

Genomic View for ANP32A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANP32A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANP32A Gene

Proteins for ANP32A Gene

  • Protein details for ANP32A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P39687-AN32A_HUMAN
    Recommended name:
    Acidic leucine-rich nuclear phosphoprotein 32 family member A
    Protein Accession:
    P39687
    Secondary Accessions:
    • B2R6T4
    • Q53FK4
    • Q5J8L8
    • Q7M4N6

    Protein attributes for ANP32A Gene

    Size:
    249 amino acids
    Molecular mass:
    28585 Da
    Quaternary structure:
    • Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B. Interacts with ELAVL1. Part of the INHAT (inhibitor of histone acetyltransferases) complex. Interacts with E4F1.
    SequenceCaution:
    • Sequence=BAD97000.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANP32A Gene

neXtProt entry for ANP32A Gene

Proteomics data for ANP32A Gene at MOPED

Post-translational modifications for ANP32A Gene

  • Phosphorylated on serine residues
  • Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).
  • The N-terminus is blocked
  • Ubiquitination at Lys 99 and Lys 116
  • Modification sites at PhosphoSitePlus

Other Protein References for ANP32A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ANP32A Gene

Domains & Families for ANP32A Gene

Gene Families for ANP32A Gene

Protein Domains for ANP32A Gene

Suggested Antigen Peptide Sequences for ANP32A Gene

Graphical View of Domain Structure for InterPro Entry

P39687

UniProtKB/Swiss-Prot:

AN32A_HUMAN :
  • Contains 1 LRRCT domain.
  • Belongs to the ANP32 family.
  • Contains 4 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
Family:
  • Belongs to the ANP32 family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ANP32A: view

Function for ANP32A Gene

Molecular function for ANP32A Gene

UniProtKB/Swiss-Prot Function:
Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.

Gene Ontology (GO) - Molecular Function for ANP32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with ANP32A: view
genes like me logo Genes that share phenotypes with ANP32A: view

Animal Models for ANP32A Gene

MGI Knock Outs for ANP32A:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANP32A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ANP32A Gene

Localization for ANP32A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANP32A Gene

Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANP32A Gene COMPARTMENTS Subcellular localization image for ANP32A gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ANP32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11555662
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 11729309
GO:0005783 endoplasmic reticulum IDA 11555662
GO:0048471 perinuclear region of cytoplasm IDA 11555662
genes like me logo Genes that share ontologies with ANP32A: view

Pathways & Interactions for ANP32A Gene

genes like me logo Genes that share pathways with ANP32A: view

Pathways by source for ANP32A Gene

Gene Ontology (GO) - Biological Process for ANP32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006913 nucleocytoplasmic transport NAS 11555662
GO:0010467 gene expression TAS --
GO:0035556 intracellular signal transduction TAS 8192856
genes like me logo Genes that share ontologies with ANP32A: view

No data available for SIGNOR curated interactions for ANP32A Gene

Drugs & Compounds for ANP32A Gene

(6) Drugs for ANP32A Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
cgmp Pharma Activation, Activator 0
estrogen Pharma 0
glutamine Nutra 137
leucine Nutra 93

(3) Additional Compounds for ANP32A Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
leptomycin b
87081-35-4
LITHIUM ION
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with ANP32A: view

Transcripts for ANP32A Gene

Unigene Clusters for ANP32A Gene

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANP32A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANP32A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: - -
SP3:

Relevant External Links for ANP32A Gene

GeneLoc Exon Structure for
ANP32A
ECgene alternative splicing isoforms for
ANP32A

Expression for ANP32A Gene

mRNA expression in normal human tissues for ANP32A Gene

mRNA differential expression in normal tissues according to GTEx for ANP32A Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for ANP32A Gene

This gene is overexpressed in Lymph node (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANP32A Gene



SOURCE GeneReport for Unigene cluster for ANP32A Gene Hs.458747

mRNA Expression by UniProt/SwissProt for ANP32A Gene

P39687-AN32A_HUMAN
Tissue specificity: Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala.
genes like me logo Genes that share expression patterns with ANP32A: view

Protein tissue co-expression partners for ANP32A Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ANP32A Gene

Orthologs for ANP32A Gene

This gene was present in the common ancestor of animals.

Orthologs for ANP32A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANP32A 35
  • 94.42 (n)
  • 96.23 (a)
ANP32A 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ANP32A 35
  • 94.61 (n)
  • 96.27 (a)
-- 36
  • 66 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ANP32A 35
  • 100 (n)
  • 100 (a)
ANP32A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anp32a 16
Anp32a 36
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ANP32A 35
  • 84.31 (n)
  • 90.76 (a)
ANP32B 36
  • 62 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia anp32a 35
  • 79.64 (n)
  • 91.62 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
anp32a 36
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mapmodulin 37
  • 55 (a)
Mapmodulin 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F33H2.3 36
  • 37 (a)
ManyToMany
T19H12.2 36
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11188 36
  • 45 (a)
OneToMany
Species with no ortholog for ANP32A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANP32A Gene

ENSEMBL:
Gene Tree for ANP32A (if available)
TreeFam:
Gene Tree for ANP32A (if available)

Paralogs for ANP32A Gene

Paralogs for ANP32A Gene

(4) SIMAP similar genes for ANP32A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ANP32A Gene

genes like me logo Genes that share paralogs with ANP32A: view

Variants for ANP32A Gene

Sequence variations from dbSNP and Humsavar for ANP32A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs14912 -- 68,815,658(-) aatca(C/T)gtgag intron-variant
rs749380 -- 68,811,499(+) CTGGC(C/T)GGGAG intron-variant
rs749381 -- 68,811,806(+) atcgg(C/G)tcaca intron-variant
rs751273 -- 68,812,048(-) CTTAA(A/G)AAAAA intron-variant
rs767453 -- 68,793,977(+) CAACA(A/T)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANP32A Gene

Variant ID Type Subtype PubMed ID
nsv833046 CNV Loss 17160897
nsv827378 CNV Gain 20364138

Variation tolerance for ANP32A Gene

Residual Variation Intolerance Score: 39.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANP32A Gene

HapMap Linkage Disequilibrium report
ANP32A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANP32A Gene

Disorders for ANP32A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANP32A Gene - From: NovoSeek

Disorder Aliases PubMed IDs
spinocerebellar ataxia 1
  • spinocerebellar ataxia type 1
- elite association

Relevant External Links for ANP32A

Genetic Association Database (GAD)
ANP32A
Human Genome Epidemiology (HuGE) Navigator
ANP32A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANP32A
genes like me logo Genes that share disorders with ANP32A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANP32A Gene

Publications for ANP32A Gene

  1. Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules. (PMID: 9144194) Ulitzur N. … Pfeffer S.R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 23 67
  2. Structure of pp32, an acidic nuclear protein which inhibits oncogene- induced formation of transformed foci. (PMID: 8970164) Chen T.-H. … Pasternack G.R. (Mol. Biol. Cell 1996) 2 23 67
  3. Metabolic targets of cardiac hormones' therapeutic anti-cancer effects. (PMID: 20030620) Vesely D.L. (Curr. Pharm. Des. 2010) 23 67
  4. The protective role of Hepatopoietin Cn on liver injury induced by carbon tetrachloride in rats*. (PMID: 19054144) Cui C.P. … Wu C.T. (Hepatol. Res. 2009) 23 67
  5. In remembrance of Eugene Ladislas Kanabrocki (18 April 1922 * 23 April 2009): a 'General' in the battle of penetrating the normal range and in revealing its relation to the cosmos. (PMID: 19997684) Halberg F. … Best W.R. (Clin Ter 2009) 23 67

Products for ANP32A Gene

Sources for ANP32A Gene

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