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ANP32A Gene

protein-coding   GIFtS: 66
GCID: GC15M069070

Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family,...


(Previous symbol: C15orf1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member A1 2     HPPCn2
C15orf11 2 3     I1PP2A2
PHAP12 3 5     PP322
Acidic Nuclear Phosphoprotein Pp322 3     Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member A2
Leucine-Rich Acidic Nuclear Protein2 3     Cerebellar Leucine Rich Acidic Nuclear Protein2
Potent Heat-Stable Protein Phosphatase 2A Inhibitor I1PP2A2 3     Hepatopoietin Cn2
Putative HLA-DR-Associated Protein I2 3     Inhibitor-1 Of Protein Phosphatase-2A2
LANP2 3     mapmodulin2
MAPM2 3     Putative Human HLA Class II Associated Protein I2
PHAPI2 3     Mapmodulin3

External Ids:    HGNC: 132331   Entrez Gene: 81252   Ensembl: ENSG000001403507   OMIM: 6008325   UniProtKB: P396873   

Export aliases for ANP32A gene to outside databases

Previous GC identifers: GC15M064912 GC15M062169 GC15M066650 GC15M066788 GC15M066859 GC15M066845 GC15M045904


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANP32A Gene:
ANP32A (acidic (leucine-rich) nuclear phosphoprotein 32 family, member A) is a protein-coding gene. Diseases associated with ANP32A include spinocerebellar degeneration, and congestive heart failure. An important paralog of this gene is ANP32D.

UniProtKB/Swiss-Prot: AN32A_HUMAN, P39687
Function: Implicated in a number of cellular processes, including proliferation, differentiation,
caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition
of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and
inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a
role in E4F1-mediated transcriptional repression

Gene Wiki entry for ANP32A (Acidic leucine-rich nuclear phosphoprotein 32 family member A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANP32A gene promoter:
         TBP   RP58   NF-1   Spz1   Ik-2   SREBP-1c   Lmo2   RelA   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANP32A promoter sequence
   Search Chromatin IP Primers for ANP32A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANP32A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q23

ANP32A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANP32A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M069070:  view genomic region     (about GC identifiers)

Start:
69,070,874 bp from pter      End:
69,113,261 bp from pter
Size:
42,388 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AN32A_HUMAN, P39687 (See protein sequence)
Recommended Name: Acidic leucine-rich nuclear phosphoprotein 32 family member A  
Size: 249 amino acids; 28585 Da
Subunit: Component of the SET complex, which also contains SET, APEX1, HMGB2 and NME1. Directly interacts with
SET. Interacts with ATXN1/SCA1. Interacts with MAP1B (By similarity). Interacts with ELAVL1. Part of the INHAT
(inhibitor of histone acetyltransferases) complex. Interacts with E4F1
Sequence caution: Sequence=BAD97000.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for ANP32A:
2JE0 (3D)        2JE1 (3D)    
Secondary accessions: B2R6T4 Q53FK4 Q5J8L8 Q7M4N6

Explore the universe of human proteins at neXtProt for ANP32A: NX_P39687

Explore proteomics data for ANP32A at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residues1
  • The N-terminus is blocked1
  • Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and
    results in a glycine chain on the gamma-carboxyl group (By similarity)1
  • Ubiquitination2 at Lys20, Lys99, Lys116
  • Modification sites at PhosphoSitePlus

  • See ANP32A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006296.1  
    ENSEMBL proteins: 
     ENSP00000417864   ENSP00000386496   ENSP00000453838  
    Reactome Protein details: P39687

    ANP32A Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for ANP32A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANP32: ANP32 acidic nuclear phosphoproteins

    2 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR003603 U2A'_phosphoprotein32A_C

    Graphical View of Domain Structure for InterPro Entry P39687

    ProtoNet protein and cluster: P39687

    1 Blocks protein domain: IPB003603 Leucine-rich-associated

    UniProtKB/Swiss-Prot: AN32A_HUMAN, P39687
    Similarity: Belongs to the ANP32 family
    Similarity: Contains 4 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain


    ANP32A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AN32A_HUMAN, P39687
    Function: Implicated in a number of cellular processes, including proliferation, differentiation,
    caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition
    of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and
    inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a
    role in E4F1-mediated transcriptional repression

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16169070
    GO:0044822poly(A) RNA binding IDA--
         
    ANP32A for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Anp32a):
     behavior/neurological  cellular  growth/size/body  mortality/aging  nervous system 
     reproductive system 

    ANP32A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ANP32A: Anp32atm1Mak Anp32atm1Hzo

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANP32A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANP32A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANP32A

    miRNA
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    miRTarBase miRNAs that target ANP32A:
    hsa-mir-615-3p (MIRT039733), hsa-mir-940 (MIRT036598), hsa-mir-148a-3p (MIRT025972), hsa-mir-21-5p (MIRT006515), hsa-mir-320a (MIRT044480), hsa-mir-1 (MIRT023840), hsa-mir-877-5p (MIRT037263)

    Block miRNA regulation of human, mouse, rat ANP32A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANP32A (see all 39):
    hsa-miR-607 hsa-miR-1260b hsa-miR-449a hsa-miR-374a* hsa-miR-3613-3p hsa-miR-520g hsa-miR-181b hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidANP32A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANP32A

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ANP32A (NM_006305)
    Sino Biological Human cDNA Clone for ANP32A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANP32A

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANP32A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AN32A_HUMAN, P39687: Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the
    process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11555662
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA11729309
    GO:0005783endoplasmic reticulum IDA11555662
    GO:0048471perinuclear region of cytoplasm IDA11555662

    ANP32A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANP32A About    
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
    Stabilization of mRNA by HuR0.00
    2Gene Expression
    Gene Expression0.40
    3Activation of DNA fragmentation factor
    Granzyme-A Pathway0.32
    4Synaptic transmission ion currents
    Synaptic transmission ion currents
    5Granzyme Pathway
    Granzyme Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ANP32A
        Granzyme-A Pathway
    Granzyme Pathway


    1 Reactome Pathway for ANP32A
        HuR stabilizes mRNA



    ANP32A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANP32A
    Interactions:

        GeneGlobe Interaction Network for ANP32A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANP32A (P396871, 2, 3 ENSP000004178644) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST4H4P628053, ENSP000003507674I2D: score=2 STRING: ENSP00000350767
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006913nucleocytoplasmic transport NAS11555662
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--

    ANP32A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANP32A (AN32A)

    9 Novoseek inferred chemical compound relationships for ANP32A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lithium ion 68.4 1 15895553 (1)
    leptomycin b 64.2 2 11018049 (1), 16306087 (1)
    cgmp 32.4 3 15948900 (1), 17201125 (1), 16598676 (1)
    leucine 20.1 2 11018049 (2)
    glutamine 5.41 1 12807913 (1)
    sodium 1.05 5 8955756 (1)
    tyrosine 0 10 1655467 (3), 15247276 (2), 1352500 (1)
    estrogen 0 9 15308690 (3), 15136563 (1), 16009334 (1)
    testosterone 0 7 7691403 (3), 16009334 (2)



    ANP32A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANP32A gene: 
    NM_006305.3  

    Unigene Cluster for ANP32A:

    Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
    Hs.458747  [show with all ESTs]
    Unigene Representative Sequence: AK127498
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465139(uc002arl.3) ENST00000409628 ENST00000486054 ENST00000267918
    ENST00000483551 ENST00000560303 ENST00000480858 ENST00000561430 ENST00000495420
    ENST00000495764 ENST00000483221
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ANP32A (see all 39):
    hsa-miR-607 hsa-miR-1260b hsa-miR-449a hsa-miR-374a* hsa-miR-3613-3p hsa-miR-520g hsa-miR-181b hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidANP32A 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ANP32A
      QuantiFast Probe-based Assays in human, mouse, rat ANP32A

    Additional mRNA sequence: 

    AF025684.1 AK127498.1 AK223280.1 AK312703.1 AY007110.1 AY349171.1 BC000608.2 BC007200.1 
    BC064969.1 BC106719.2 BC125143.1 BT007436.1 U60823.1 U73477.1 X75090.1 

    22 DOTS entries:

    DT.91681431  DT.452718  DT.92011286  DT.99939300  DT.121049953  DT.121050094  DT.121050045  DT.100878961 
    DT.97854941  DT.100722272  DT.100857085  DT.121020093  DT.100878957  DT.100878962  DT.121050144  DT.91643680 
    DT.92450018  DT.92456454  DT.95248817  DT.121020173  DT.121050018  DT.92064181 

    Selected AceView cDNA sequences (see all 478):

    CR598445 AW468611 AA346716 AA488448 CR606008 BM701427 AW134561 AA449078 
    T31837 BI860951 AA983358 NM_006305 BX447580 AA722054 AW517406 AI085346 
    AA669756 BP429139 X75090 AI270006 AI142616 AI224146 CD366804 AA463472 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ANP32A    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
    SP1:                                      -                           
    SP2:                          -           -                           
    SP3:                                                                  


    ECgene alternative splicing isoforms for ANP32A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANP32A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCATCTGT
    ANP32A Expression
    About this image


    ANP32A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Metanephros
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
    ANP32A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANP32A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458747

    UniProtKB/Swiss-Prot: AN32A_HUMAN, P39687
    Tissue specificity: Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate
    levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the
    brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in
    amygdala

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    QuantiFast Probe-based Assays in human, mouse, rat ANP32A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANP32A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANP32A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anp32a5 acidic (leucine-rich) nuclear phosphoprotein 32 family, more   --   9 (33.68 cM) 62341293 
    chicken
    (Gallus gallus)
    Aves ANP32A1 acidic (leucine-rich) nuclear phosphoprotein 32 family, more 84.31(n)
    90.76(a)
      415562  XM_004943929.1  XP_004943986.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    82(a)
    1 → many
    GL343671.1(255827-265447)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060336.12   -- 77.12(n)    BC060336.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC048047.12   -- 75.58(n)   335907  BC048047.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mapmodulin3 microtubule-based process microtubule
    binding
    55(a)   54F4   --
    worm
    (Caenorhabditis elegans)
    Secernentea F33H2.36
    T19H12.26
    Protein T19H12.2 (T19H12.2) mRNA, complete cds
    37(a)
    35(a)
    many ↔ many
    many ↔ many
    I(15034517-15035467) WBGene00009367
    V(4890429-4891422) WBGene00020588


    ENSEMBL Gene Tree for ANP32A (if available)
    TreeFam Gene Tree for ANP32A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANP32A gene
    ANP32D2  ANP32B2  ANP32E2  
    4 SIMAP similar genes for ANP32A using alignment to 6 protein entries:     AN32A_HUMAN (see all proteins):
    ANP32D    ANP32B    ANP32C    ANP32E

    ANP32A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ANP32A
    PGOHUM00000262917 PGOHUM00000262003


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ANP32A (see all 687)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs21680101,2
    C,F,A,H--69070536(-) AGCCAA/GTTTAC 1 -- int135Minor allele frequency- N:0.00NS EA NA WA CSA 3000
    rs1494748621,2
    --69070635(+) TTGTAC/TTAAGA 1 -- int10--------
    rs1439571201,2
    --69070655(+) AAAGTA/GTAAAT 1 -- int10--------
    rs1486504851,2
    --69070656(+) AAGTAC/TAAATA 1 -- int10--------
    rs1852978871,2
    --69070681(+) AATATC/GCACTA 1 -- int10--------
    rs740205101,2
    C,F--69070707(+) CATAAT/CGAAAA 1 -- int13Minor allele frequency- C:0.35WA CSA 122
    rs589833401,2
    C,F--69070986(+) TTGGCC/TCAACT 1 -- ut313Minor allele frequency- T:0.38WA CSA 121
    rs1889577561,2
    --69070992(+) CAACTC/TGATTG 1 -- ut310--------
    rs2003353041,2
    C--69070995(+) CTTGA-/TTGT  
            
    TTGGG
    1 -- ut310--------
    rs604150231,2
    C,F--69071163(+) AGCTTC/TCCCCT 1 -- ut312Minor allele frequency- T:0.36WA 120

    HapMap Linkage Disequilibrium report for ANP32A (69070874 - 69113261 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ANP32A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833046CNV Loss17160897
    nsv827378CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANP32A
    DNA2.0 Custom Variant and Variant Library Synthesis for ANP32A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600832    OMIM disorders: --

    Selected diseases for ANP32A (see all 29):    
    About MalaCards
    spinocerebellar degeneration    congestive heart failure    prostate adenocarcinoma    spinocerebellar ataxia
    pancreatic ductal adenocarcinoma    retinoblastoma    brain cancer    ataxia
    lung cancer    labyrinthitis    adenocarcinoma    prostatitis
    esophageal squamous cell carcinoma    osteoarthritis    pancreatitis    prostate cancer
    tonsillitis    esophagitis    squamous cell carcinoma    pancreatic cancer

    1 disease from the University of Copenhagen DISEASES database for ANP32A:
    Spinocerebellar ataxia

    ANP32A for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ANP32A gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spinocerebellar ataxia type 1 75.7 2 17557114 (1), 12807913 (1)
    squamous cell lung cancer 70.7 2 20030620 (1)
    spinocerebellar degenerations 68.2 2 17557114 (1), 12807913 (1)
    prostatic adenocarcinoma 57.8 7 17201125 (2), 14695340 (1), 16598676 (1), 7691403 (1)
    adenocarcinoma 32.9 13 17906614 (4), 18210743 (2), 16297362 (2), 15948900 (1) (see all 6)
    prostate carcinoma 19.3 4 9146727 (2), 10086381 (1)
    retinoblastoma 16.7 7 16009334 (4)
    neurodegenerative diseases 14.8 1 17557114 (1)
    neurodegeneration 10.4 1 12807913 (1)
    prostate cancer 10.2 7 10086381 (2), 17906614 (1), 16009334 (1)

    Genetic Association Database (GAD): ANP32A
    Human Genome Epidemiology (HuGE) Navigator: ANP32A (4 documents)

    Export disorders for ANP32A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANP32A gene, integrated from 10 sources (see all 108):
    (articles sorted by number of sources associating them with ANP32A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of pp32, an acidic nuclear protein which inhibits oncogene- induced formation of transformed foci. (PubMed id 8970164)1, 2, 3, 9 Chen T.-H.... Pasternack G.R. (Mol. Biol. Cell 1996)
    2. The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1. (PubMed id 9353121)1, 2, 9 Matilla A....Zoghbi H.Y. (Nature 1997)
    3. The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. (PubMed id 17557114)1, 2, 9 Cvetanovic M....Opal P. (EMBO Rep. 2007)
    4. Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules. (PubMed id 9144194)1, 3, 9 Ulitzur N....Pfeffer S.R. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    5. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. (PubMed id 15642345)1, 2, 9 Tsujio I.... Iqbal K. (FEBS Lett. 2005)
    6. Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A. (PubMed id 8679524)1, 2, 9 Li M.... Damuni Z. (Biochemistry 1996)
    7. The Anp32 family of proteins containing leucine-rich repeats. (PubMed id 15895553)1, 2, 9 Matilla A. and Radrizzani M. (Cerebellum 2005)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women. (PubMed id 19565487)1, 4 Valdes A.M....Spector T.D. (Arthritis Rheum. 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8125 HGNC: 13233 AceView: ANP32A Ensembl:ENSG00000140350 euGenes: HUgn8125
    ECgene: ANP32A H-InvDB: ANP32A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ANP32A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANP32A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ANP32A gene:
    Search GeneIP for patents involving ANP32A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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