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Aliases for ANP32A Gene

Aliases for ANP32A Gene

  • Acidic Nuclear Phosphoprotein 32 Family Member A 2 3 5
  • Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member A 2 3
  • Potent Heat-Stable Protein Phosphatase 2A Inhibitor I1PP2A 3 4
  • Putative HLA-DR-Associated Protein I 3 4
  • Leucine-Rich Acidic Nuclear Protein 3 4
  • Acidic Nuclear Phosphoprotein Pp32 3 4
  • Mapmodulin 3 4
  • C15orf1 3 4
  • PHAP1 3 4
  • PHAPI 3 4
  • PP32 3 4
  • LANP 3 4
  • MAPM 3 4
  • Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member A 3
  • Putative Human HLA Class II Associated Protein I 3
  • Cerebellar Leucine Rich Acidic Nuclear Protein 3
  • Inhibitor-1 Of Protein Phosphatase-2A 3
  • Hepatopoietin Cn 3
  • I1PP2A 3
  • HPPCn 3

External Ids for ANP32A Gene

Previous HGNC Symbols for ANP32A Gene

  • C15orf1

Previous GeneCards Identifiers for ANP32A Gene

  • GC15M064912
  • GC15M062169
  • GC15M066650
  • GC15M066788
  • GC15M066859
  • GC15M066845
  • GC15M069070
  • GC15M045904

Summaries for ANP32A Gene

GeneCards Summary for ANP32A Gene

ANP32A (Acidic Nuclear Phosphoprotein 32 Family Member A) is a Protein Coding gene. Diseases associated with ANP32A include Spinocerebellar Ataxia 1. Among its related pathways are Apoptosis induced DNA fragmentation and DNA Damage. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is ANP32B.

UniProtKB/Swiss-Prot for ANP32A Gene

  • Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.

Gene Wiki entry for ANP32A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANP32A Gene

Genomics for ANP32A Gene

Regulatory Elements for ANP32A Gene

Enhancers for ANP32A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F068776 1 Ensembl ENCODE 26.5 +44.7 44674 1.9 PAF1 BCOR ZNF146 ZNF280D ZNF175 ZMYM3 CEBPG ZNF518A NR2F2 ZNF335 ANP32A SPESP1 ENSG00000137808 NOX5 MIR4312 CARSP1
GH15F068786 1.6 FANTOM5 Ensembl ENCODE 13.5 +27.8 27764 12.5 HDGF PKNOX1 WRNIP1 FEZF1 GLI4 ZNF2 YY2 JUNB REST TBX21 ENSG00000259265 ENSG00000259410 ANP32A CORO2B PIAS1 MIR4312 CARSP1
GH15F068780 1.3 Ensembl ENCODE 13.3 +38.5 38536 3.2 SIN3A GLI4 FEZF1 DMAP1 ZNF2 ZNF48 YY1 GLIS2 ZNF207 ZNF416 PIAS1 ANP32A MIR4312 CARSP1
GH15F068725 1.1 Ensembl ENCODE 12 +94.8 94822 1.0 HDAC1 ZFP64 ZNF766 SCRT2 SP5 CEBPB ZEB2 TGIF2 NFIL3 MIER3 ANP32A SPESP1 ENSG00000137808 NOX5 GC15P068742 GC15M068584
GH15F068729 1 Ensembl ENCODE 12 +90.3 90269 2.1 CTCF KLF1 KLF17 ZNF384 RAD21 ZFHX2 GATA3 SMC3 EGR2 ZNF263 ANP32A SPESP1 ENSG00000137808 NOX5 GC15P068742 GC15M068584
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANP32A on UCSC Golden Path with GeneCards custom track

Promoters for ANP32A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000410388 1222 5801 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for ANP32A Gene

Chromosome:
15
Start:
68,778,535 bp from pter
End:
68,820,922 bp from pter
Size:
42,388 bases
Orientation:
Minus strand

Genomic View for ANP32A Gene

Genes around ANP32A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANP32A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANP32A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANP32A Gene

Proteins for ANP32A Gene

  • Protein details for ANP32A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P39687-AN32A_HUMAN
    Recommended name:
    Acidic leucine-rich nuclear phosphoprotein 32 family member A
    Protein Accession:
    P39687
    Secondary Accessions:
    • B2R6T4
    • Q53FK4
    • Q5J8L8
    • Q7M4N6

    Protein attributes for ANP32A Gene

    Size:
    249 amino acids
    Molecular mass:
    28585 Da
    Quaternary structure:
    • Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B. Interacts with ELAVL1. Part of the INHAT (inhibitor of histone acetyltransferases) complex. Interacts with E4F1.
    SequenceCaution:
    • Sequence=BAD97000.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANP32A Gene

neXtProt entry for ANP32A Gene

Post-translational modifications for ANP32A Gene

  • Phosphorylated on serine residues.
  • Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).
  • The N-terminus is blocked.
  • Ubiquitination at Lys 99 and Lys 116
  • Modification sites at PhosphoSitePlus

Other Protein References for ANP32A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANP32A (ANP32A)
  • Cloud-Clone Corp. Antibodies for ANP32A

No data available for DME Specific Peptides for ANP32A Gene

Domains & Families for ANP32A Gene

Gene Families for ANP32A Gene

Protein Domains for ANP32A Gene

Suggested Antigen Peptide Sequences for ANP32A Gene

Graphical View of Domain Structure for InterPro Entry

P39687

UniProtKB/Swiss-Prot:

AN32A_HUMAN :
  • Contains 1 LRRCT domain.
  • Belongs to the ANP32 family.
  • Contains 4 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
Family:
  • Belongs to the ANP32 family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ANP32A: view

Function for ANP32A Gene

Molecular function for ANP32A Gene

UniProtKB/Swiss-Prot Function:
Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.

Gene Ontology (GO) - Molecular Function for ANP32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
GO:0042393 histone binding IBA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with ANP32A: view

Phenotypes for ANP32A Gene

GenomeRNAi human phenotypes for ANP32A:
genes like me logo Genes that share phenotypes with ANP32A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANP32A Gene

Localization for ANP32A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANP32A Gene

Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANP32A gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ANP32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11555662
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,TAS 11729309
GO:0005783 endoplasmic reticulum IEA,IDA 11555662
GO:0048471 perinuclear region of cytoplasm IDA 11555662
genes like me logo Genes that share ontologies with ANP32A: view

Pathways & Interactions for ANP32A Gene

genes like me logo Genes that share pathways with ANP32A: view

Pathways by source for ANP32A Gene

1 Cell Signaling Technology pathway for ANP32A Gene
2 Qiagen pathways for ANP32A Gene

Gene Ontology (GO) - Biological Process for ANP32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 NOT nucleosome assembly IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006913 nucleocytoplasmic transport NAS 11555662
GO:0035556 intracellular signal transduction TAS 8192856
genes like me logo Genes that share ontologies with ANP32A: view

No data available for SIGNOR curated interactions for ANP32A Gene

Drugs & Compounds for ANP32A Gene

(6) Drugs for ANP32A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for ANP32A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANP32A: view

Transcripts for ANP32A Gene

Unigene Clusters for ANP32A Gene

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANP32A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: - -
SP3:

Relevant External Links for ANP32A Gene

GeneLoc Exon Structure for
ANP32A
ECgene alternative splicing isoforms for
ANP32A

Expression for ANP32A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANP32A Gene

mRNA differential expression in normal tissues according to GTEx for ANP32A Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for ANP32A Gene

This gene is overexpressed in Lymph node (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANP32A Gene



Protein tissue co-expression partners for ANP32A Gene

NURSA nuclear receptor signaling pathways regulating expression of ANP32A Gene:

ANP32A

SOURCE GeneReport for Unigene cluster for ANP32A Gene:

Hs.458747

mRNA Expression by UniProt/SwissProt for ANP32A Gene:

P39687-AN32A_HUMAN
Tissue specificity: Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala.
genes like me logo Genes that share expression patterns with ANP32A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ANP32A Gene

Orthologs for ANP32A Gene

This gene was present in the common ancestor of animals.

Orthologs for ANP32A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANP32A 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia ANP32A 34
  • 94.61 (n)
-- 35
  • 66 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ANP32A 34 35
  • 94.42 (n)
mouse
(Mus musculus)
Mammalia Anp32a 35
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ANP32A 34
  • 84.31 (n)
ANP32B 35
  • 62 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 82 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia anp32a 34
  • 79.64 (n)
zebrafish
(Danio rerio)
Actinopterygii anp32a 35
  • 79 (a)
OneToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Mapmodulin 36 35
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea F33H2.3 35
  • 37 (a)
ManyToMany
T19H12.2 35
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11188 35
  • 45 (a)
OneToMany
Species where no ortholog for ANP32A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANP32A Gene

ENSEMBL:
Gene Tree for ANP32A (if available)
TreeFam:
Gene Tree for ANP32A (if available)

Paralogs for ANP32A Gene

Paralogs for ANP32A Gene

(4) SIMAP similar genes for ANP32A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ANP32A Gene

genes like me logo Genes that share paralogs with ANP32A: view

Variants for ANP32A Gene

Sequence variations from dbSNP and Humsavar for ANP32A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10450991 -- 68,786,092(+) GGAGA(A/G)CAAGG intron-variant
rs10593379 -- 68,821,528(+) CCAGC(-/AGC)CCGCG upstream-variant-2KB
rs10689979 -- 68,801,819(+) TGAGT(-/CA)CACAC intron-variant, downstream-variant-500B
rs11072054 -- 68,814,478(+) TGGCC(A/C)ACTGT intron-variant
rs111435300 -- 68,808,360(+) CACAC(-/CTT)CTTCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ANP32A Gene

Variant ID Type Subtype PubMed ID
esv3636811 CNV loss 21293372
nsv1070281 CNV deletion 25765185
nsv1126398 CNV deletion 24896259
nsv827378 CNV gain 20364138
nsv833046 CNV loss 17160897
nsv951984 CNV deletion 24416366

Variation tolerance for ANP32A Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANP32A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANP32A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANP32A Gene

Disorders for ANP32A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANP32A Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
spinocerebellar ataxia 1
  • spinocerebellar ataxia type 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANP32A

Genetic Association Database (GAD)
ANP32A
Human Genome Epidemiology (HuGE) Navigator
ANP32A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANP32A
genes like me logo Genes that share disorders with ANP32A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANP32A Gene

Publications for ANP32A Gene

  1. Structure of pp32, an acidic nuclear protein which inhibits oncogene- induced formation of transformed foci. (PMID: 8970164) Chen T.-H. … Pasternack G.R. (Mol. Biol. Cell 1996) 2 3 4 22 64
  2. The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. (PMID: 17557114) Cvetanovic M. … Opal P. (EMBO Rep. 2007) 3 4 22 64
  3. The Anp32 family of proteins containing leucine-rich repeats. (PMID: 15895553) Matilla A. … Radrizzani M. (Cerebellum 2005) 3 4 22 64
  4. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. (PMID: 15642345) Tsujio I. … Iqbal K. (FEBS Lett. 2005) 3 4 22 64
  5. Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules. (PMID: 9144194) Ulitzur N. … Pfeffer S.R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 22 64

Products for ANP32A Gene

Sources for ANP32A Gene

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