Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANP32A Gene

protein-coding GIFtS: 62
GCID: GC15M069070

acidic (leucine-rich) nuclear phosphoprotein 32 family,...

(Previous symbol: C15orf1)

Explore 27 diseases affiliated with
ANP32A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member A¹ ²		Leucine-Rich Acidic Nuclear Protein² ³
C15orf1¹ ² ³		Potent Heat-Stable Protein Phosphatase 2A Inhibitor I1PP2A² ³
LANP¹ ² ³		Putative HLA-DR-Associated Protein I² ³
MAPM¹ ² ³		HPPCn²
PHAPI¹ ² ³		Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member A²
PHAP1² ³ ⁵		Cerebellar Leucine Rich Acidic Nuclear Protein²
I1PP2A¹ ²		Hepatopoietin Cn²
PP32¹ ²		Inhibitor-1 Of Protein Phosphatase-2A²
Mapmodulin³		Putative Human HLA Class II Associated Protein I²
Acidic Nuclear Phosphoprotein Pp32² ³		Mapmodulin³

External Ids:	HGNC: 13233¹	Entrez Gene: 8125²	Ensembl: ENSG00000140350⁷	OMIM: 600832⁵	UniProtKB: P39687³

Export aliases for ANP32A gene to outside databases

Previous GC identifers: GC15M064912 GC15M062169 GC15M066650 GC15M066788 GC15M066859 GC15M066845 GC15M045904

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AN32A_HUMAN, P39687

Function: Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and

caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A,

regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part

of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional

repression

Gene Wiki entry for ANP32A (Acidic leucine-rich nuclear phosphoprotein 32 family member A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANP32A gene promoter:
TBP RP58 NF-1 Spz1 Ik-2 SREBP-1c Lmo2 RelA SREBP-1b
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANP32A promoter sequence

Search SABiosciences Chromatin IP Primers for ANP32A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANP32A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23 Ensembl cytogenetic band: 15q23 HGNC cytogenetic band: 15q23

ANP32A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANP32A gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M069070: view genomic region (about GC identifiers)

Start:	69,070,874 bp from pter	End:	69,113,261 bp from pter
Size:	42,388 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AN32A_HUMAN, P39687 (See protein sequence)

Recommended Name: Acidic leucine-rich nuclear phosphoprotein 32 family member A

Size: 249 amino acids; 28585 Da

Subunit: Component of the SET complex, which also contains SET, APEX1, HMGB2 and NME1. Directly interacts with SET.

Interacts with ATXN1/SCA1. Interacts with MAP1B (By similarity). Interacts with ELAVL1. Part of the INHAT (inhibitor

of histone acetyltransferases) complex. Interacts with E4F1

Subcellular location: Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process

of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm

Sequence caution: Sequence=BAD97000.1; Type=Erroneous initiation;

2 PDB 3D structures from and Proteopedia for ANP32A:

2JE0 (3D)

2JE1 (3D)

Secondary accessions: B2R6T4 Q53FK4 Q5J8L8 Q7M4N6

Explore the universe of human proteins at neXtProt for ANP32A: NX_P39687

Post-translational modifications:

Phosphorylated on serine residues¹

The N-terminus is blocked¹

Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results

in a glycine chain on the gamma-carboxyl group (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P39687

ANP32A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006296.1

ENSEMBL proteins:

ENSP00000417864 ENSP00000386496 ENSP00000453838

Reactome Protein details: P39687
Human Recombinant Protein Products for ANP32A:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ANP32A OriGene Protein Over-expression Lysate: ANP32A OriGene Custom Protein Services for ANP32A
	GenScript Custom Purified and Recombinant Proteins Services for ANP32A
	Novus Biologicals ANP32A Proteins Novus Biologicals ANP32A Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for ANP32A
	Uscn Proteins for ANP32A

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11729309
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IDA	12524539
GO:0005783	endoplasmic reticulum	IDA	12524539
GO:0048471	perinuclear region of cytoplasm	IDA	12524539

ANP32A for ontologies About GeneDecksing

ANP32A Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 4): ANP32A OriGene Custom Antibody Services for ANP32A
	GenScript Custom Superior Antibodies Services for ANP32A
	Novus Biologicals ANP32A Antibodies
	Abcam antibodies for ANP32A
	Uscn Antibodies for ANP32A
	ThermoFisher Antibodies for ANP32A

Assay Products for ANP32A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ANP32A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ANP32A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANP32A for domains About GeneDecksing

3 InterPro domains/families:

IPR003603 U2A'_phosphoprotein32A_C

IPR001611 Leu-rich_rpt

IPR025875 Leu-rich_rpt_4

Graphical View of Domain Structure for InterPro Entry P39687

ProtoNet protein and cluster: P39687

1 Blocks protein family: IPB003603 Leucine-rich-associated

UniProtKB/Swiss-Prot: AN32A_HUMAN, P39687

Similarity: Belongs to the ANP32 family

Similarity: Contains 4 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRCT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: AN32A_HUMAN, P39687

Function: Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and

caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A,

regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part

of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional

repression

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16169070

ANP32A for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Anp32a):

behavior/neurological	cellular	growth/size	mortality/aging	nervous system
reproductive system

ANP32A for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for ANP32A: Anp32a^tm1Mak Anp32a^tm1Hzo

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ANP32A

miRNA Products:		OriGene 3'-UTR Clone: ANP32A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANP32A
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate ANP32A (see all 39):
		hsa-miR-607 hsa-miR-1260b hsa-miR-449a hsa-miR-374a* hsa-miR-3613-3p hsa-miR-520g hsa-miR-181b hsa-miR-3163

		SwitchGear 3'UTR luciferase reporter plasmid: ANP32A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANP32A (see all 7) OriGene shRNA RFP: ANP32A OriGene siRNA: ANP32A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANP32A
		Sirion Biotech Custom design and validation of potent shRNA sequences against ANP32A

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ANP32A
			Sirion Biotech Customized adenovirus for overexpression of ANP32A Sirion Biotech Customized adenovirus for potent knockdown of ANP32A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANP32A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANP32A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ANP32A (NM_006305)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANP32A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANP32A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ANP32A
		Search LifeMap BioReagents cell lines for ANP32A
		Sirion Biotech Customized stable knockdown cell line services for ANP32A Sirion Biotech Customized inducible knockdown cell line services for ANP32A Sirion Biotech Customized stable overexpressing cell line services for ANP32A Sirion Biotech Customized inducible overexpressing cell line services for ANP32A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANP32A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Stabilization of mRNA by HuR

Stabilization of mRNA by HuR

1.00

Export of HuR:mRNA Complex from the Nucleus to the Cytoplasm

0.75

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Synaptic transmission: ion currents

Synaptic transmission: ion currents

1.00

Granzyme Pathway

Granzyme Pathway

1.00

Ubiquitinated Orc1 is degraded by the proteasome

Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

0.55

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ANP32A

Synaptic transmission- ion currents

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANP32A

	Granzyme-A Pathway
	Granzyme Pathway

5/6 Reactome Pathways for ANP32A (see all 6)

	Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
	Metabolism of RNA
	Metabolism of mRNA
	Export of HuR:mRNA Complex from the Nucleus to the Cytoplasm
	Gene Expression

ANP32A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ANP32A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/68 Interacting proteins for ANP32A (P39687^{1, 2, 3} ENSP00000417864⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 68)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST4H4	P62805³, ENSP00000350767⁴	I2D: score=2 STRING: ENSP00000350767
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=2 STRING: ENSP00000352980
HIST1H4B	P62805³	I2D: score=2
HIST1H4C	P62805³	I2D: score=2
HIST1H4D	P62805³	I2D: score=2

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006913	nucleocytoplasmic transport	NAS	11555662
GO:0010467	gene expression	TAS	--
GO:0016070	RNA metabolic process	TAS	--

ANP32A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ANP32A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANP32A
9 Novoseek chemical compound relationships for ANP32A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lithium ion	68.4	1	15895553 (1)
leptomycin b	64.2	2	11018049 (1), 16306087 (1)
cgmp	32.4	3	15948900 (1), 17201125 (1), 16598676 (1)
leucine	20.1	2	11018049 (2)
glutamine	5.41	1	12807913 (1)
sodium	1.05	5	10502206 (3), 8955756 (1)
tyrosine	0	10	1655467 (3), 15247276 (2), 1352500 (1)
estrogen	0	9	15308690 (3), 15136563 (1), 16009334 (1)
testosterone	0	7	7691403 (3), 16009334 (2)

Search CenterWatch for drugs/clinical trials and news about ANP32A / AN32A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ANP32A gene:

NM_006305.3

Unigene Cluster for ANP32A:

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A

Hs.458747 [show with all ESTs]

Unigene Representative Sequence: AK127498

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000465139(uc002arl.3) ENST00000409628 ENST00000486054 ENST00000267918

ENST00000483551 ENST00000560303 ENST00000480858 ENST00000561430 ENST00000495420

ENST00000495764 ENST00000483221

miRNA Products:		OriGene 3'-UTR Clone: ANP32A Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANP32A
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate ANP32A (see all 39):
		hsa-miR-607 hsa-miR-1260b hsa-miR-449a hsa-miR-374a* hsa-miR-3613-3p hsa-miR-520g hsa-miR-181b hsa-miR-3163

		SwitchGear 3'UTR luciferase reporter plasmid: ANP32A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANP32A (see all 7) OriGene shRNA RFP: ANP32A OriGene siRNA: ANP32A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANP32A
		Sirion Biotech Custom design and validation of potent shRNA sequences against ANP32A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANP32A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANP32A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ANP32A (NM_006305)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANP32A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANP32A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANP32A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ANP32A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANP32A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANP32A

Additional cDNA sequence:

AF025684.1 AK127498.1 AK223280.1 AK312703.1 AY007110.1 AY349171.1 BC000608.2 BC007200.1

BC064969.1 BC106719.2 BC125143.1 BT007436.1 U60823.1 U73477.1 X75090.1

22 DOTS entries:

DT.91681431 DT.452718 DT.92011286 DT.99939300 DT.121049953 DT.121050094 DT.121050045 DT.100878961

DT.97854941 DT.100722272 DT.100857085 DT.121020093 DT.100878957 DT.100878962 DT.121050144 DT.91643680

DT.92450018 DT.92456454 DT.95248817 DT.121020173 DT.121050018 DT.92064181

24/478 AceView cDNA sequences (see all 478):

AW005626 AW468096 AW517406 AW290994 BG325466 AL517375 AI094246 BC000608

AA722054 AA463472 NM_006305 BM460209 AA488448 AI167290 AA252167 BQ004465

AI685436 BM727078 CR598445 AA669756 X75090 BU171439 N39511 BE220766

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ANP32A About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7
SP1:													-
SP2:									-				-
SP3:

ECgene alternative splicing isoforms for ANP32A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANP32A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCATCTGT

About this image

ANP32A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Intermediate Mesoderm

Intermediate Mesoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ANP32A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANP32A

SOURCE GeneReport for Unigene cluster: Hs.458747

UniProtKB/Swiss-Prot: AN32A_HUMAN, P39687

Tissue specificity: Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of

expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined

(amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala

SABiosciences Custom PCR Arrays for ANP32A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANP32A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ANP32A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANP32A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANP32A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANP32A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANP32A gene from 9/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Anp32a^{1 , 5}	acidic (leucine-rich) nuclear phosphoprotein 32 family, more^{1, 5}	88.26(n)¹ 89.47(a)¹		9 (33.68 cM)⁵ 11737¹ NM_009672.3¹ NP_033802.2¹ 62341293⁵
chicken (Gallus gallus)	Aves	ANP32A¹	acidic (leucine-rich) nuclear phosphoprotein 32 family, more	82.93(n) 88.71(a)		415562 XM_413932.3 XP_413932.3
lizard (Anolis carolinensis)	Reptilia	--	--	79(a)	1 → many	GL343671.1(255827-265447)
African clawed frog (Xenopus laevis)	Amphibia	BC060336.1²	--	77.12(n)		BC060336.1
zebrafish (Danio rerio)	Actinopterygii	BC048047.1²	--	75.58(n)		335907 BC048047.1
fruit fly (Drosophila melanogaster)	Insecta	Mapmodulin^{1 , 3}	microtubule-based process microtubule binding³ CG5784-PA¹	55(a)³ 51.26(n)¹ 44(a)¹		54F4³ 37043¹ NM_001169713.1¹ NP_001163184.1¹
worm (Caenorhabditis elegans)	Secernentea	F33H2.3⁶ T19H12.2⁶	Acidic leucine-rich nuclear phosphoprotein 32-rela... Acidic leucine-rich nuclear phosphoprotein 32-rela...	30(a) 28(a)	many ↔ many many ↔ many	I(15034506-15035456) V(4890415-4891408)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G50690⁶	acidic leucine-rich nuclear phosphoprotein 32-rela...	20(a)	1 → many	3(18834967-18837097)
rice (Oryza sativa)	Liliopsida	-- --	acidic leucine-rich nuclear phosphoprotein 32-rela... acidic leucine-rich nuclear phosphoprotein 32-rela...	29(a) 17(a)	many ↔ many many ↔ many	3(26370745-26372962) 7(24983636-24987375)

ENSEMBL Gene Tree for ANP32A (if available)
TreeFam Gene Tree for ANP32A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANP32A gene

ANP32D² ANP32B² ANP32E²

4 SIMAP similar genes for ANP32A using alignment to 6 protein entries: AN32A_HUMAN (see all proteins):

ANP32D ANP32B ANP32C ANP32E

ANP32A for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for ANP32A
PGOHUM00000262917 PGOHUM00000262003

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2168010^1,2	C,F,A,H	--	69070536(-)	`AGCCAA/GTTTAC`	1	--	int¹		35		NS EA NA WA CSA	3000
rs149474862^1,2		--	69070635(+)	`TTGTAC/TTAAGA`	1	--	int¹		0	--	--	--	--
rs143957120^1,2		--	69070655(+)	`AAAGTA/GTAAAT`	1	--	int¹		0	--	--	--	--
rs148650485^1,2		--	69070656(+)	`AAGTAC/TAAATA`	1	--	int¹		0	--	--	--	--
rs185297887^1,2		--	69070681(+)	`AATATC/GCACTA`	1	--	int¹		0	--	--	--	--
rs74020510^1,2	C,F	--	69070707(+)	`CATAAT/CGAAAA`	1	--	int¹		3		WA CSA	122
rs58983340^1,2	C	--	69070986(+)	`TTGGCC/TCAACT`	1	--	ut3¹		3		WA CSA	121
rs188957756^1,2		--	69070992(+)	`CAACTC/TGATTG`	1	--	ut3¹		0	--	--	--	--
rs200335304^1,2		--	69070995(+)	`CTTGA-/TTGT TTGGG`	1	--	ut3¹		0	--	--	--	--
rs60415023^1,2	C	--	69071163(+)	`AGCTTC/TCCCCT`	1	--	ut3¹		2		WA	120

HapMap Linkage Disequilibrium report for ANP32A (69070874 - 69113261 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANP32A: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANP32A

DNA2.0 Custom Variant and Variant Library Synthesis for ANP32A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANP32A for disorders           About GeneDecksing

OMIM gene information: 600832    OMIM disorders: --

20/27 diseases for ANP32A (see all 27):    About MalaCards

spinocerebellar degeneration spinocerebellar ataxia congestive heart failure corpus callosum

esophageal squamous cell carcinoma squamous cell carcinoma pancreatic ductal adenocarcinoma neurodegenerative disease

epithelial ovarian cancer neurodegeneration ovarian cancer adenocarcinoma

ataxia retinoblastoma prostatitis prostate carcinoma

lung cancer prostate cancer hepatocellular carcinoma carcinoma

1 disease from the University of Copenhagen DISEASES database for ANP32A:

Spinocerebellar ataxia

10/13 Novoseek disease relationships for ANP32A gene (see all 13) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
spinocerebellar ataxia type 1	75.7	2	17557114 (1), 12807913 (1)
squamous cell lung cancer	70.7	2	16487258 (1), 20030620 (1)
spinocerebellar degenerations	68.2	2	17557114 (1), 12807913 (1)
prostatic adenocarcinoma	57.8	7	17201125 (2), 14695340 (1), 16598676 (1), 7691403 (1) (see all 5)
adenocarcinoma	32.9	13	17906614 (4), 18210743 (2), 16297362 (2), 15948900 (1) (see all 7)
heart failure congestive	23.8	2	11979389 (1), 10502206 (1)
prostate carcinoma	19.3	4	9146727 (2), 10086381 (1)
retinoblastoma	16.7	7	16009334 (4)
neurodegenerative diseases	14.8	1	17557114 (1)
neurodegeneration	10.4	1	12807913 (1)

Human Genome Epidemiology (HuGE) Navigator: ANP32A (4 documents)

Export disorders for ANP32A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANP32A gene, integrated from 9 sources (see all 107):
(articles sorted by number of sources associating them with ANP32A)

Utopia: connect your pdf to the dynamic
world of online information

Structure of pp32, an acidic nuclear protein which inhibits oncogene- induced formation of transformed foci. (PubMed id 8970164)^{1, 2, 3, 9} Chen T.-H.... Pasternack G.R. (1996)
The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1. (PubMed id 9353121)^{1, 2, 9} Matilla A....Zoghbi H.Y. (1997)
The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. (PubMed id 17557114)^{1, 2, 9} Cvetanovic M....Opal P. (2007)
Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules. (PubMed id 9144194)^{1, 3, 9} Ulitzur N....Pfeffer S.R. (1997)
Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. (PubMed id 15642345)^{1, 2, 9} Tsujio I.... Iqbal K. (2005)
Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A. (PubMed id 8679524)^{1, 2, 9} Li M.... Damuni Z. (1996)
The Anp32 family of proteins containing leucine-rich repeats. (PubMed id 15895553)^{1, 2, 9} Matilla A. and Radrizzani M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. (PubMed id 12524539)^{1, 2} Fan Z.... Lieberman J. (2003)
Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the Set oncoprotein. (PubMed id 11163245)^{1, 2} Seo S.-B.... Chakravarti D. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8125	HGNC: 13233	AceView: ANP32A	Ensembl:ENSG00000140350	euGenes: HUgn8125
ECgene: ANP32A	H-InvDB: ANP32A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANP32A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ANP32A	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ANP32A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ANP32A gene:
Search GeneIP for patents involving ANP32A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for ANP32A		OriGene shRNA RFP for ANP32A
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANP32A		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANP32A
	OriGene Protein Over-expression Lysate for ANP32A		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ANP32A		OriGene 3'-UTR Clone for ANP32A
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANP32A		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANP32A
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for ANP32A		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ANP32A		OriGene Custom Protein Services for ANP32A
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANP32A
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANP32A
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANP32A
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANP32A
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANP32A
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANP32A

	GenScript Custom Purified and Recombinant Proteins Services for ANP32A		GenScript cDNA clones with any tag delivered in your preferred vector for ANP32A
	GenScript Custom Assay Services for ANP32A		GenScript Custom Superior Antibodies Services for ANP32A
	GenScript Custom overexpressing Cell Line Services for ANP32A		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ANP32A promoter
	Search Chromatin IP Primers for ANP32A
	RT² qPCR Primer Assay in human, mouse, rat ANP32A
	GNC Network for ANP32A
	SABiosciences PCR Arrays including human, mouse, rat ANP32A

Search Tocris compounds for ANP32A

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ANP32A antibodies
	ANP32A proteins
	ANP32A lysates

	Antibodies for ANP32A
	See all of Abcam's Antibodies, Kits and Proteins for ANP32A
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for ANP32A

ANP32A Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ANP32A

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANP32A

	SwitchGear 3'UTR luciferase reporter plasmids for ANP32A
	SwitchGear Promoter luciferase reporter plasmids for ANP32A

ThermoFisher Antibodies for ANP32A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANP32A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ANP32A

Sirion Biotech Customized:

	stable knockdown cell line services for ANP32A
	inducible knockdown cell line services for ANP32A
	design and validation of potent shRNA sequences against ANP32A
	adenovirus for potent knockdown of ANP32A
	adenovirus for overexpression of ANP32A
	stable overexpressing cell line services for ANP32A
	inducible overexpressing cell line services for ANP32A

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ANP32A gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

ANP32A Gene

acidic (leucine-rich) nuclear phosphoprotein 32 family,...

Aliases
for ANP32A gene

Summaries
for ANP32A gene

Genomic Views
for ANP32A gene

Proteins
for ANP32A gene

Protein Domains /
Families
for ANP32A gene

Function
for ANP32A gene

Pathways & Interactions
for ANP32A gene

Drugs & Compounds
for ANP32A gene

Transcripts
for ANP32A gene

Expression
for ANP32A gene

Orthologs
for ANP32A gene

Paralogs
for ANP32A gene

Genomic Variants
for ANP32A gene

Disorders / Diseases
for ANP32A gene

Publications
for ANP32A gene

External Searches for ANP32A gene

Genome Databases showing ANP32A gene

Other Databases showing ANP32A gene

Specialized Databases showing ANP32A gene

Intellectual Property
for ANP32A gene

Products
for ANP32A gene

View Random Gene

ANP32A (Gene Symbol)
Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member A
C15orf1
LANP
MAPM
PHAPI
PHAP1
I1PP2A
PP32
Mapmodulin
Acidic Nuclear Phosphoprotein Pp32
Leucine-Rich Acidic Nuclear Protein
Potent Heat-Stable Protein Phosphatase 2A Inhibitor I1PP2A
Putative HLA-DR-Associated Protein I
HPPCn
Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member A
Cerebellar Leucine Rich Acidic Nuclear Protein
Hepatopoietin Cn
Inhibitor-1 Of Protein Phosphatase-2A
Putative Human HLA Class II Associated Protein I
Mapmodulin

Advanced Search

Export list of displayed genes

ANP32A Gene

acidic (leucine-rich) nuclear phosphoprotein 32 family,...

Aliasesfor ANP32A gene

Summariesfor ANP32A gene

Genomic Viewsfor ANP32A gene

Proteinsfor ANP32A gene

Protein Domains /Familiesfor ANP32A gene

Functionfor ANP32A gene

Pathways & Interactionsfor ANP32A gene

Drugs & Compoundsfor ANP32A gene

Transcriptsfor ANP32A gene

Expression for ANP32A gene

Orthologsfor ANP32A gene

Paralogsfor ANP32A gene

Genomic Variantsfor ANP32A gene

Disorders / Diseasesfor ANP32A gene

Publicationsfor ANP32A gene

External Searches for ANP32A gene

Genome Databases showing ANP32A gene

Other Databases showing ANP32A gene

Specialized Databases showing ANP32A gene

Intellectual Propertyfor ANP32A gene

Productsfor ANP32A gene

View Random Gene

Aliases
for ANP32A gene

Summaries
for ANP32A gene

Genomic Views
for ANP32A gene

Proteins
for ANP32A gene

Protein Domains /
Families
for ANP32A gene

Function
for ANP32A gene

Pathways & Interactions
for ANP32A gene

Drugs & Compounds
for ANP32A gene

Transcripts
for ANP32A gene

Expression
for ANP32A gene

Orthologs
for ANP32A gene

Paralogs
for ANP32A gene

Genomic Variants
for ANP32A gene

Disorders / Diseases
for ANP32A gene

Publications
for ANP32A gene

Intellectual Property
for ANP32A gene

Products
for ANP32A gene