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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANP32A Gene

protein-coding   GIFtS: 65
GCID: GC15M069070

Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family,...


(Previous symbol: C15orf1)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member A1 2     HPPCn2
C15orf11 2 3     I1PP2A2
PHAP12 3 5     PP322
Acidic Nuclear Phosphoprotein Pp322 3     Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member A2
Leucine-Rich Acidic Nuclear Protein2 3     Cerebellar Leucine Rich Acidic Nuclear Protein2
Potent Heat-Stable Protein Phosphatase 2A Inhibitor I1PP2A2 3     Hepatopoietin Cn2
Putative HLA-DR-Associated Protein I2 3     Inhibitor-1 Of Protein Phosphatase-2A2
LANP2 3     mapmodulin2
MAPM2 3     Putative Human HLA Class II Associated Protein I2
PHAPI2 3     Mapmodulin3

External Ids:    HGNC: 132331   Entrez Gene: 81252   Ensembl: ENSG000001403507   OMIM: 6008325   UniProtKB: P396873   

Export aliases for ANP32A gene to outside databases

Previous GC identifers: GC15M064912 GC15M062169 GC15M066650 GC15M066788 GC15M066859 GC15M066845 GC15M045904


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ANP32A Gene: 
ANP32A (acidic (leucine-rich) nuclear phosphoprotein 32 family, member A) is a protein-coding gene. Diseases associated with ANP32A include spinocerebellar degeneration, and congestive heart failure, and among its related super-pathways are Metabolism of RNA and Destabilization of mRNA by AUF1 (hnRNP D0). GO annotations related to this gene include protein binding. An important paralog of this gene is ANP32D.

UniProtKB/Swiss-Prot: AN32A_HUMAN, P39687
Function: Implicated in a number of cellular processes, including proliferation, differentiation,
caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition
of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and
inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a
role in E4F1-mediated transcriptional repression

Gene Wiki entry for ANP32A (Acidic leucine-rich nuclear phosphoprotein 32 family member A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANP32A gene promoter:
         TBP   RP58   NF-1   Spz1   Ik-2   SREBP-1c   Lmo2   RelA   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANP32A promoter sequence
   Search SABiosciences Chromatin IP Primers for ANP32A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANP32A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q23

ANP32A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANP32A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M069070:  view genomic region     (about GC identifiers)

Start:
69,070,874 bp from pter      End:
69,113,261 bp from pter
Size:
42,388 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AN32A_HUMAN, P39687 (See protein sequence)
Recommended Name: Acidic leucine-rich nuclear phosphoprotein 32 family member A  
Size: 249 amino acids; 28585 Da
Subunit: Component of the SET complex, which also contains SET, APEX1, HMGB2 and NME1. Directly interacts with
SET. Interacts with ATXN1/SCA1. Interacts with MAP1B (By similarity). Interacts with ELAVL1. Part of the INHAT
(inhibitor of histone acetyltransferases) complex. Interacts with E4F1
Subcellular location: Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the
process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm
Sequence caution: Sequence=BAD97000.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for ANP32A:
2JE0 (3D)        2JE1 (3D)    
Secondary accessions: B2R6T4 Q53FK4 Q5J8L8 Q7M4N6

Explore the universe of human proteins at neXtProt for ANP32A: NX_P39687

Explore proteomics data for ANP32A at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on serine residues
  • UniProtKB: The N-terminus is blocked
  • UniProtKB: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and
    results in a glycine chain on the gamma-carboxyl group (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P39687

  • ANP32A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANP32A Protein Expression
    REFSEQ proteins: NP_006296.1  
    ENSEMBL proteins: 
     ENSP00000417864   ENSP00000386496   ENSP00000453838  
    Reactome Protein details: P39687
    Human Recombinant Protein Products for ANP32A: 
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    Cloud-Clone Corp. Proteins for ANP32A 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11555662
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA11729309
    GO:0005783endoplasmic reticulum IDA11555662
    GO:0048471perinuclear region of cytoplasm IDA11555662

    ANP32A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANP32: ANP32 acidic nuclear phosphoproteins

    3 InterPro protein domains:
     IPR003603 U2A'_phosphoprotein32A_C
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4

    Graphical View of Domain Structure for InterPro Entry P39687

    ProtoNet protein and cluster: P39687

    1 Blocks protein domain: IPB003603 Leucine-rich-associated

    UniProtKB/Swiss-Prot: AN32A_HUMAN, P39687
    Similarity: Belongs to the ANP32 family
    Similarity: Contains 4 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain


    ANP32A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AN32A_HUMAN, P39687
    Function: Implicated in a number of cellular processes, including proliferation, differentiation,
    caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition
    of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and
    inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a
    role in E4F1-mediated transcriptional repression

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16169070
         
    ANP32A for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Anp32a):
     behavior/neurological  cellular  growth/size  mortality/aging  nervous system 
     reproductive system 

    ANP32A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ANP32A: Anp32atm1Mak Anp32atm1Hzo

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ANP32A 
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    SwitchGear 3'UTR luciferase reporter plasmidANP32A 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ANP32A About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    2CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.63
    3Generic Transcription Pathway
    Gene Expression0.47
    4Granzyme Pathway
    Granzyme Pathway0.42
    5Activation of DNA fragmentation factor
    Granzyme-A Pathway0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ANP32A
        Synaptic transmission- ion currents

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANP32A
        Granzyme-A Pathway
    Granzyme Pathway


    5        Reactome Pathways for ANP32A
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression
    Stabilization of mRNA by HuR



    ANP32A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANP32A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/68 Interacting proteins for ANP32A (P396871, 2, 3 ENSP000004178644) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST4H4P628053, ENSP000003507674I2D: score=2 STRING: ENSP00000350767
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006913nucleocytoplasmic transport NAS11555662
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--

    ANP32A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANP32A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANP32A (AN32A)

    9 Novoseek inferred chemical compound relationships for ANP32A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lithium ion 68.4 1 15895553 (1)
    leptomycin b 64.2 2 11018049 (1), 16306087 (1)
    cgmp 32.4 3 15948900 (1), 17201125 (1), 16598676 (1)
    leucine 20.1 2 11018049 (2)
    glutamine 5.41 1 12807913 (1)
    sodium 1.05 5 10502206 (3), 8955756 (1)
    tyrosine 0 10 1655467 (3), 15247276 (2), 1352500 (1)
    estrogen 0 9 15308690 (3), 15136563 (1), 16009334 (1)
    testosterone 0 7 7691403 (3), 16009334 (2)

    Search CenterWatch for drugs/clinical trials and news about ANP32A / AN32A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANP32A gene: 
    NM_006305.3  

    Unigene Cluster for ANP32A:

    Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
    Hs.458747  [show with all ESTs]
    Unigene Representative Sequence: AK127498
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465139(uc002arl.3) ENST00000409628 ENST00000486054 ENST00000267918
    ENST00000483551 ENST00000560303 ENST00000480858 ENST00000561430 ENST00000495420
    ENST00000495764 ENST00000483221

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    hsa-miR-607 hsa-miR-1260b hsa-miR-449a hsa-miR-374a* hsa-miR-3613-3p hsa-miR-520g hsa-miR-181b hsa-miR-3163
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    Additional mRNA sequence: 

    AF025684.1 AK127498.1 AK223280.1 AK312703.1 AY007110.1 AY349171.1 BC000608.2 BC007200.1 
    BC064969.1 BC106719.2 BC125143.1 BT007436.1 U60823.1 U73477.1 X75090.1 

    22 DOTS entries:

    DT.91681431  DT.452718  DT.92011286  DT.99939300  DT.121049953  DT.121050094  DT.121050045  DT.100878961 
    DT.97854941  DT.100722272  DT.100857085  DT.121020093  DT.100878957  DT.100878962  DT.121050144  DT.91643680 
    DT.92450018  DT.92456454  DT.95248817  DT.121020173  DT.121050018  DT.92064181 

    24/478 AceView cDNA sequences (see all 478):

    AI224146 BM834972 AI074701 T31837 BM465827 AL517375 AV696252 BQ687251 
    AA814661 BQ229967 CR606008 BF969229 AI270006 AA983358 AW005626 BU171439 
    CR598445 AW404428 BI860951 BM759930 BU633894 AI581703 BG325466 AW468096 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ANP32A    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
    SP1:                                      -                           
    SP2:                          -           -                           
    SP3:                                                                  


    ECgene alternative splicing isoforms for ANP32A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANP32A expression in normal human tissues (normalized intensities)      ANP32A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCATCTGT
    ANP32A Expression
    About this image


    ANP32A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/46 selected tissues (see all 46) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             brain/forebrain/telencephalon   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             stem cells (umbilical cord cd34+)   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Stem Bronchi
             lung ; pneumocytes   

    See ANP32A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANP32A

    SOURCE GeneReport for Unigene cluster: Hs.458747

    UniProtKB/Swiss-Prot: AN32A_HUMAN, P39687
    Tissue specificity: Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate
    levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the
    brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in
    amygdala

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANP32A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ANP32A gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anp32a1 , 5 acidic (leucine-rich) nuclear phosphoprotein 32 family, more1, 5 88.26(n)1
    89.47(a)1
      9 (33.68 cM)5
    117371  NM_009672.31  NP_033802.21 
     623412935 
    chicken
    (Gallus gallus)
    Aves ANP32A1 acidic (leucine-rich) nuclear phosphoprotein 32 family, more 82.93(n)
    88.71(a)
      415562  XM_413932.3  XP_413932.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    82(a)
    1 → many
    GL343671.1(255827-265447)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060336.12   -- 77.12(n)    BC060336.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC048047.12   -- 75.58(n)   335907  BC048047.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mapmodulin1 , 3 microtubule-based process microtubule
    binding3
    CG5784-PA1
    55(a)3
    51.26(n)1
    44(a)1
      54F43
    370431  NM_001169713.11  NP_001163184.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F33H2.36
    T19H12.26
    Acidic leucine-rich nuclear phosphoprotein 32-rela...
    Acidic leucine-rich nuclear phosphoprotein 32-rela...
    34(a)
    31(a)
    many ↔ many
    many ↔ many
    I(15034517-15035467)
    V(4890429-4891422)


    ENSEMBL Gene Tree for ANP32A (if available)
    TreeFam Gene Tree for ANP32A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANP32A gene
    ANP32D2  ANP32B2  ANP32E2  
    4 SIMAP similar genes for ANP32A using alignment to 6 protein entries:     AN32A_HUMAN (see all proteins):
    ANP32D    ANP32B    ANP32C    ANP32E

    ANP32A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ANP32A
    PGOHUM00000262917 PGOHUM00000262003


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/687 SNPs in ANP32A are shown (see all 687)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs21680101,2
    C,F,A,H--69070536(-) AGCCAA/GTTTAC 1 -- int135Minor allele frequency- N:0.00NS EA NA WA CSA 3000
    rs1494748621,2
    --69070635(+) TTGTAC/TTAAGA 1 -- int10--------
    rs1439571201,2
    --69070655(+) AAAGTA/GTAAAT 1 -- int10--------
    rs1486504851,2
    --69070656(+) AAGTAC/TAAATA 1 -- int10--------
    rs1852978871,2
    --69070681(+) AATATC/GCACTA 1 -- int10--------
    rs740205101,2
    C,F--69070707(+) CATAAT/CGAAAA 1 -- int13Minor allele frequency- C:0.35WA CSA 122
    rs589833401,2
    C,F--69070986(+) TTGGCC/TCAACT 1 -- ut313Minor allele frequency- T:0.38WA CSA 121
    rs1889577561,2
    --69070992(+) CAACTC/TGATTG 1 -- ut310--------
    rs2003353041,2
    C--69070995(+) CTTGA-/TTGT  
            
    TTGGG
    1 -- ut310--------
    rs604150231,2
    C,F--69071163(+) AGCTTC/TCCCCT 1 -- ut312Minor allele frequency- T:0.36WA 120

    HapMap Linkage Disequilibrium report for ANP32A (69070874 - 69113261 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ANP32A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833046CNV Loss17160897
    nsv827378CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ANP32A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600832    OMIM disorders: --

    20/22 diseases for ANP32A (see all 22):    About MalaCards
    spinocerebellar degeneration    congestive heart failure    spinocerebellar ataxia    pancreatic ductal adenocarcinoma
    retinoblastoma    ataxia    prostate adenocarcinoma    lung cancer
    prostatitis    esophageal squamous cell carcinoma    osteoarthritis    adenocarcinoma
    pancreatitis    ovarian cancer    esophagitis    prostate cancer
    squamous cell carcinoma    pancreatic cancer    hepatocellular carcinoma    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for ANP32A:
    Spinocerebellar ataxia

    ANP32A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/13 Novoseek inferred disease relationships for ANP32A gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spinocerebellar ataxia type 1 75.7 2 17557114 (1), 12807913 (1)
    squamous cell lung cancer 70.7 2 16487258 (1), 20030620 (1)
    spinocerebellar degenerations 68.2 2 17557114 (1), 12807913 (1)
    prostatic adenocarcinoma 57.8 7 17201125 (2), 14695340 (1), 16598676 (1), 7691403 (1) (see all 5)
    adenocarcinoma 32.9 13 17906614 (4), 18210743 (2), 16297362 (2), 15948900 (1) (see all 7)
    heart failure congestive 23.8 2 11979389 (1), 10502206 (1)
    prostate carcinoma 19.3 4 9146727 (2), 10086381 (1)
    retinoblastoma 16.7 7 16009334 (4)
    neurodegenerative diseases 14.8 1 17557114 (1)
    neurodegeneration 10.4 1 12807913 (1)

    Genetic Association Database (GAD): ANP32A
    Human Genome Epidemiology (HuGE) Navigator: ANP32A (4 documents)

    Export disorders for ANP32A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANP32A gene, integrated from 9 sources (see all 113):
    (articles sorted by number of sources associating them with ANP32A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of pp32, an acidic nuclear protein which inhibits oncogene- induced formation of transformed foci. (PubMed id 8970164)1, 2, 3, 9 Chen T.-H.... Pasternack G.R. (1996)
    2. The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1. (PubMed id 9353121)1, 2, 9 Matilla A....Zoghbi H.Y. (1997)
    3. The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. (PubMed id 17557114)1, 2, 9 Cvetanovic M....Opal P. (2007)
    4. Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules. (PubMed id 9144194)1, 3, 9 Ulitzur N....Pfeffer S.R. (1997)
    5. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. (PubMed id 15642345)1, 2, 9 Tsujio I.... Iqbal K. (2005)
    6. Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A. (PubMed id 8679524)1, 2, 9 Li M.... Damuni Z. (1996)
    7. The Anp32 family of proteins containing leucine-rich repeats. (PubMed id 15895553)1, 2, 9 Matilla A. and Radrizzani M. (2005)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women. (PubMed id 19565487)1, 4 Valdes A.M....Spector T.D. (2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8125 HGNC: 13233 AceView: ANP32A Ensembl:ENSG00000140350 euGenes: HUgn8125
    ECgene: ANP32A H-InvDB: ANP32A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANP32A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANP32A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANP32A gene:
    Search GeneIP for patents involving ANP32A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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