ANO9 Gene
protein-coding GIFtS : 48 GCID: GC11 M000409
anoctamin 9 tumor protein p53 inducible protein 5, transmembrane protein... TP53I5, TMEM16J )
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Aliasesfor ANO9 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Anoctamin 9 1 2 Tumor Protein P53 Inducible Protein 51 2 Transmembrane Protein 16J1 2 3 Tumor Protein P53-Inducible Protein 52 3 PIG51 2 3 P53-Induced Gene 5 Protein2 3 TMEM16J1 2 3 Anoctamin-91 TP53I51 2 3
Export aliases for ANO9 gene to outside databases Previous GC identifer: GC11M000233
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Summariesfor ANO9 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ANO9_HUMAN, A1A5B4 Function : Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1
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Genomic Viewsfor ANO9 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_009237.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ANO9 gene promoter:Spz1 AML1a HNF-4alpha2 Cdc5 HNF-4alpha1 Egr-2 AREB6 PPAR-gamma1 PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for ANO9 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5 ANO9 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M000409: view genomic region
(about GC identifiers )
Start: 417,930 bp from pter End:
442,011 bp from pter
Size: 24,082 bases Orientation:
minus strand
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Proteinsfor ANO9 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ANO9_HUMAN, A1A5B4 See
protein sequence )Recommended Name: Size : 782 amino acids; 90367 DaSubcellular location : Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellularlocalization with a weak expression in the cell membrane
Miscellaneous : The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology
Sequence caution : Sequence=BAB84914.1; Type=Miscellaneous discrepancy; Note=Intron retention;Secondary accessions : B3KUC4 B4E134 Q8TEN4Alternative splicing : 3 isoforms : A1A5B4-1 A1A5B4-2 A1A5B4-3 Explore the universe of human proteins at neXtProt for ANO9: NX_A1A5B4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_A1A5B4 ANO9 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_001012302.2 ENSEMBL proteins: ENSP00000332788 Reactome Protein details: A1A5B4 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing ANO9 Antibody Products: Assay Products for ANO9:
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Protein
Domains /for ANO9 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry A1A5B4 ProtoNet protein and cluster: A1A5B4
UniProtKB/Swiss-Prot: ANO9_HUMAN, A1A5B4 Similarity : Belongs to the anoctamin family
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Functionfor ANO9 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ANO9_HUMAN, A1A5B4 Function : Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANO9 (NM_001012302 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANO9 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat ANO9
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO9
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005229 NOT intracellular calcium activated chloride channel activityIDA -- GO:0005254 chloride channel activity
-- --
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Pathways & Interactionsfor ANO9 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Ion channel transport 2 SLC-mediated transmembrane transport
Pathway sources See GeneCards unified pathways Show all pathways 3 About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANO9 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for ANO9 (ENSP00000332788 4 via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor ANO9 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ANO9 2 HMDB Compounds for ANO9 About this table ANO9
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Transcriptsfor ANO9 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ANO9 gene: NM_001012302.2 Unigene Cluster for ANO9:
Anoctamin 9 Hs.501622 [show with all ESTs ] Unigene Representative Sequence: NM_001012302 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000526142 ENST00000534161 (uc001lph.2 ) ENST00000532094 (uc001lpi.2 uc010qvv.1 )ENST00000528927 ENST00000332826 ENST00000524802 ENST00000525804 ENST00000525857 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANO9 (NM_001012302 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANO9 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat ANO9
Additional cDNA sequence: AK026923.1 AK096874.1 AK303642.1 AK316479.1 BC047946.1 BC128557.1 BC144415.1 U33271.1
10 DOTS entries : DT.100758133 DT.208422
DT.100020944 DT.95342153 DT.95084413 DT.120739674 DT.95358143 DT.100721400 DT.120739692 DT.91962126 24/63 AceView cDNA sequences (see all 63 ):
AA909821 AI826039 AI739306 BM834800 AK096874 BU729166 BX105541 AI697244 CB141922 AW341433 CB305739 AI283197 AI290806 AI361787 BM821793 BU687606 AI246657 AI190369 AI697075 AA429265 AI222741 AA428446 AI281218 AW079412 GeneLoc Exon Structure 5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ANO9 (see all 11 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · SP1 : - - - - - SP2 : - - - SP3 : - - - SP4 : - - - SP5 : -
ExUns: 18b · 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b SP1 : - - SP2 : - - SP3 : - - SP4 : - SP5 :
ECgene alternative splicing isoforms for ANO9
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Expression for ANO9 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ANO9 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGGGGCCGCA
About this image ANO9 expression in embryonic tissues and stem cells About this table See ANO9 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ANO9 SOURCE GeneReport for Unigene cluster: Hs.501622 SABiosciences Custom PCR Arrays for ANO9 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO9
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Orthologsfor ANO9 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ANO9 gene from 7/21 species (see all 21 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves ANO96
Uncharacterized protein
46(a)
1 ↔ 1
5(1562140-1568346)
lizard Reptilia ANO96
--
57(a)
1 ↔ 1
1(76434024-76461782)
zebrafish Actinopterygii LOC5598091
anoctamin-9-like
54.95(n) 46.62(a)
559809 XM_001922625.3 XP_001922660.2
fruit fly Insecta CG69386
--
21(a)
1 → many
3L(11978006-11983605)
worm Secernentea anoh-16
--
15(a)
possible ortholog
III(13246477-13253514)
thale cress eudicotyledons AT1G730206
uncharacterized protein
17(a)
1 → many
1(27469534-27473554)
rice Liliopsida --
transmembrane protein 16K, putative, expressed
18(a)
1 → many
1(29317147-29321524)
ENSEMBL Gene Tree for ANO9 (if available)TreeFam Gene Tree for ANO9 (if available)
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Paralogsfor ANO9 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ANO9 gene ANO6 2 ANO2 2 ANO5 2 ANO1 2 ANO10 2 ANO3 2 ANO4 2 ANO8 2 ANO7 2 7 SIMAP similar genes for ANO9 using alignment to 1 protein entry: ANO9_HUMAN :ANO4 ANO3 ANO7 ANO2 ANO5 ANO6 ANO1 About GeneDecksing
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Genomic Variantsfor ANO9 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 11 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ANO9 (417930 - 442011 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 13 variations for ANO9 9 CNVs 101101 29880 30528 29881 3831 29882 29883 6915 71215 4 Indels 24734 41923 41832 44891
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ANO9 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About MalaCards About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: ANO9 (1 document)Export disorders for ANO9 gene to outside databases
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Publicationsfor ANO9 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ANO9 gene, integrated from 9 sources (see all 18 ):(articles sorted by number of sources associating them with ANO9) Utopia : connect your pdf to the dynamic
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 (2004) A model for p53-induced apoptosis. (PubMed id 9305847) 1 , 3(1997) Identification and characterization of human TP53I5 and mouse Tp53i5 genes in silico. (PubMed id 15202010) 1 , 9(2004) Common polymorphisms in the PKP3-SIGIRR-TMEM16J gene r egion are associated with susceptibility to tuberculosis. (PubMed id 22223854) 1 (2012) The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PubMed id 21984732) 2 (2012) Anoctamins are a family of Ca2+ activated Cl- channels. (PubMed id 22946059) 2 (2012) The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age. (PubMed id 22302790) 2 (2012) CFTR and TMEM16A are separate but functionally related Cl- channels. (PubMed id 22178883) 2 (2011) Anoctamins. (PubMed id 21607626) 2 (2011) Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels? (PubMed id 21642943) 2 (2011)
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External Searches for ANO9 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ANO9 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ANO9 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ANO9 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for ANO9 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ANO9 gene: ANO9 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ANO9 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ANO9 OriGene 3'-UTR Clone for ANO9 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ANO9 OriGene Custom Protein Services for ANO9 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANO9 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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ANO9 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO9
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat ANO9
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
Microarrays
