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Aliases for ANO9 Gene

Aliases for ANO9 Gene

  • Anoctamin 9 2 3
  • Transmembrane Protein 16J 2 3 4
  • Tumor Protein P53 Inducible Protein 5 2 3
  • Tumor Protein P53-Inducible Protein 5 3 4
  • P53-Induced Gene 5 Protein 3 4
  • TMEM16J 3 4
  • TP53I5 3 4
  • PIG5 3 4
  • Anoctamin-9 3

External Ids for ANO9 Gene

Previous Symbols for ANO9 Gene

  • TP53I5
  • TMEM16J

Summaries for ANO9 Gene

GeneCards Summary for ANO9 Gene

ANO9 (Anoctamin 9) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include intracellular calcium activated chloride channel activity. An important paralog of this gene is ANO5.

UniProtKB/Swiss-Prot for ANO9 Gene

  • Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANO9 Gene

Genomics for ANO9 Gene

Genomic Location for ANO9 Gene

417,930 bp from pter
442,011 bp from pter
24,082 bases
Minus strand

Genomic View for ANO9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANO9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANO9 Gene

Regulatory Elements for ANO9 Gene

Proteins for ANO9 Gene

  • Protein details for ANO9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KUC4
    • B4E134
    • Q8TEN4

    Protein attributes for ANO9 Gene

    782 amino acids
    Molecular mass:
    90367 Da
    Quaternary structure:
    No Data Available
    • The term anoctamin was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology
    • Sequence=BAB84914.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANO9 Gene


neXtProt entry for ANO9 Gene

Proteomics data for ANO9 Gene at MOPED

Post-translational modifications for ANO9 Gene

  • Glycosylation at Asn641, Asn652, Asn674, and Asn690

Other Protein References for ANO9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ANO9 Gene

Domains for ANO9 Gene

Gene Families for ANO9 Gene

  • ANO :Ion channels / Chloride channels : Calcium activated : Anoctamins

Protein Domains for ANO9 Gene



  • Belongs to the anoctamin family.:
    • A1A5B4
genes like me logo Genes that share domains with ANO9: view

Function for ANO9 Gene

Molecular function for ANO9 Gene

UniProtKB/Swiss-Prot Function: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.

Gene Ontology (GO) - Molecular Function for ANO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005229 intracellular calcium activated chloride channel activity IMP 22946059
GO:0017128 phospholipid scramblase activity IEA --
genes like me logo Genes that share ontologies with ANO9: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ANO9 Gene

Localization for ANO9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANO9 Gene

Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.

Subcellular locations from

Jensen Localization Image for ANO9 Gene COMPARTMENTS Subcellular localization image for ANO9 gene
Compartment Confidence
plasma membrane 5
peroxisome 2

Gene Ontology (GO) - Cellular Components for ANO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANO9: view

Pathways for ANO9 Gene

genes like me logo Genes that share pathways with ANO9: view

Pathways by source for ANO9 Gene

Interacting Proteins for ANO9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000332788 for ANO9 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ANO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006821 chloride transport IMP 22946059
GO:0006869 lipid transport IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
GO:0061589 calcium activated phosphatidylserine scrambling IEA --
genes like me logo Genes that share ontologies with ANO9: view

Compounds for ANO9 Gene

(2) HMDB Compounds for ANO9 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • Cl2
genes like me logo Genes that share compounds with ANO9: view

Transcripts for ANO9 Gene

Unigene Clusters for ANO9 Gene

Anoctamin 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANO9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: -
SP7: -

ExUns: 18b · 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b
SP1: - -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for ANO9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANO9 Gene

mRNA expression in normal human tissues for ANO9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANO9 Gene

This gene is overexpressed in Colon - Transverse (8.4), Small Intestine - Terminal Ileum (7.4), Skin - Not Sun Exposed (Suprapubic) (6.6), and Skin - Sun Exposed (Lower leg) (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANO9 Gene

SOURCE GeneReport for Unigene cluster for ANO9 Gene Hs.501622

genes like me logo Genes that share expressions with ANO9: view

Orthologs for ANO9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANO9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANO9 37
  • 98 (a)
(Canis familiaris)
Mammalia ANO9 36
  • 83.26 (n)
  • 79.15 (a)
ANO9 37
  • 77 (a)
(Mus musculus)
Mammalia Ano9 36
  • 77.61 (n)
  • 74.22 (a)
Ano9 16
Ano9 37
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia ANO9 37
  • 64 (a)
(Rattus norvegicus)
Mammalia Ano9 36
  • 79.06 (n)
  • 76.93 (a)
(Gallus gallus)
Aves ANO9 36
  • 67.72 (n)
  • 60.55 (a)
ANO9 37
  • 59 (a)
(Anolis carolinensis)
Reptilia ANO9 37
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493850 36
  • 63.53 (n)
  • 59.4 (a)
(Danio rerio)
Actinopterygii ANO9 (2 of 2) 37
  • 46 (a)
ano9a 37
  • 42 (a)
LOC559809 36
  • 57.65 (n)
  • 50.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6938 37
  • 21 (a)
Species with no ortholog for ANO9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANO9 Gene

Gene Tree for ANO9 (if available)
Gene Tree for ANO9 (if available)

Paralogs for ANO9 Gene

Paralogs for ANO9 Gene

Selected SIMAP similar genes for ANO9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANO9: view

Variants for ANO9 Gene

Sequence variations from dbSNP and Humsavar for ANO9 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs6421975 -- 443,731(-) TCCTT(C/T)GCCCT upstream-variant-2KB
rs6598021 -- 438,939(-) GCCCT(C/G)AGACT intron-variant
rs6598022 -- 433,135(-) TCCCC(A/G)TCCCA intron-variant
rs6598023 -- 424,291(-) GTTTC(C/T)CATGT intron-variant
rs7102822 -- 439,879(-) GCACA(C/T)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANO9 Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv896463 CNV Gain 21882294
nsv527327 CNV Loss 19592680
dgv918n71 CNV Loss 21882294
dgv182e199 CNV Deletion 23128226
dgv919n71 CNV Loss 21882294
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
dgv924n71 CNV Loss 21882294
nsv467633 CNV Loss 19166990
nsv896502 CNV Loss 21882294
nsv469923 CNV Loss 18288195
dgv925n71 CNV Loss 21882294
nsv896514 CNV Gain 21882294
nsv896517 CNV Loss 21882294
nsv896518 CNV Gain+Loss 21882294
dgv927n71 CNV Loss 21882294
dgv928n71 CNV Gain+Loss 21882294
dgv929n71 CNV Loss 21882294
dgv930n71 CNV Loss 21882294
dgv931n71 CNV Loss 21882294
nsv896530 CNV Gain+Loss 21882294
nsv896532 CNV Gain 21882294
nsv896534 CNV Gain 21882294
essv23843 CNV CNV 17122850
esv1960258 CNV Deletion 18987734
esv3908 CNV Deletion 18987735
esv1003820 CNV Deletion 20482838
esv1030132 CNV Deletion 17803354
nsv825677 CNV Loss 20364138
esv2476569 CNV Deletion 19546169
esv3176 CNV Deletion 18987735
esv270933 CNV Insertion 20981092
esv273658 CNV Insertion 20981092
nsv8754 CNV Gain 18304495
esv32925 CNV Gain 17666407
esv29363 CNV Loss 19812545

Relevant External Links for ANO9 Gene

HapMap Linkage Disequilibrium report

Disorders for ANO9 Gene

Relevant External Links for ANO9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ANO9: view

No data available for UniProtKB/Swiss-Prot for ANO9 Gene

Publications for ANO9 Gene

  1. Anoctamins are a family of Ca2+ activated Cl- channels. (PMID: 22946059) Tian Y. … Kunzelmann K. (J. Cell Sci. 2012) 3 4
  2. Structure and function of TMEM16 proteins (anoctamins). (PMID: 24692353) Pedemonte N. … Galietta L.J. (Physiol. Rev. 2014) 2 3
  3. Identification and characterization of human TP53I5 and mouse Tp53i5 genes in silico. (PMID: 15202010) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 3 23
  4. A model for p53-induced apoptosis. (PMID: 9305847) Polyak K. … Vogelstein B. (Nature 1997) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ANO9 Gene

Sources for ANO9 Gene

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