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Aliases for ANO9 Gene

Aliases for ANO9 Gene

  • Anoctamin 9 2 3 5
  • Transmembrane Protein 16J 2 3 4
  • Tumor Protein P53 Inducible Protein 5 2 3
  • Tumor Protein P53-Inducible Protein 5 3 4
  • P53-Induced Gene 5 Protein 3 4
  • TMEM16J 3 4
  • TP53I5 3 4
  • PIG5 3 4

External Ids for ANO9 Gene

Previous HGNC Symbols for ANO9 Gene

  • TP53I5
  • TMEM16J

Previous GeneCards Identifiers for ANO9 Gene

  • GC11M000409
  • GC11M000233
  • GC11M000418
  • GC11M000419

Summaries for ANO9 Gene

GeneCards Summary for ANO9 Gene

ANO9 (Anoctamin 9) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include intracellular calcium activated chloride channel activity and phospholipid scramblase activity. An important paralog of this gene is ANO5.

UniProtKB/Swiss-Prot for ANO9 Gene

  • Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANO9 Gene

Genomics for ANO9 Gene

Regulatory Elements for ANO9 Gene

Enhancers for ANO9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANO9 on UCSC Golden Path with GeneCards custom track

Promoters for ANO9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANO9 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANO9 Gene

Chromosome:
11
Start:
417,930 bp from pter
End:
442,011 bp from pter
Size:
24,082 bases
Orientation:
Minus strand

Genomic View for ANO9 Gene

Genes around ANO9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANO9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANO9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANO9 Gene

Proteins for ANO9 Gene

  • Protein details for ANO9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A5B4-ANO9_HUMAN
    Recommended name:
    Anoctamin-9
    Protein Accession:
    A1A5B4
    Secondary Accessions:
    • B3KUC4
    • B4E134
    • Q8TEN4

    Protein attributes for ANO9 Gene

    Size:
    782 amino acids
    Molecular mass:
    90333 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The term anoctamin was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
    SequenceCaution:
    • Sequence=BAB84914.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANO9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANO9 Gene

Proteomics data for ANO9 Gene at MOPED

Post-translational modifications for ANO9 Gene

  • Glycosylation at Asn 641, Asn 652, Asn 674, and Asn 690
  • Modification sites at PhosphoSitePlus

Other Protein References for ANO9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANO9 Gene

Domains & Families for ANO9 Gene

Gene Families for ANO9 Gene

Protein Domains for ANO9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANO9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1A5B4

UniProtKB/Swiss-Prot:

ANO9_HUMAN :
  • Belongs to the anoctamin family.
Family:
  • Belongs to the anoctamin family.
genes like me logo Genes that share domains with ANO9: view

Function for ANO9 Gene

Molecular function for ANO9 Gene

UniProtKB/Swiss-Prot Function:
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.

Gene Ontology (GO) - Molecular Function for ANO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005229 intracellular calcium activated chloride channel activity TAS --
genes like me logo Genes that share ontologies with ANO9: view

Phenotypes for ANO9 Gene

genes like me logo Genes that share phenotypes with ANO9: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANO9 Gene

Localization for ANO9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANO9 Gene

Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANO9 Gene COMPARTMENTS Subcellular localization image for ANO9 gene
Compartment Confidence
plasma membrane 5
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for ANO9 Gene

Pathways & Interactions for ANO9 Gene

genes like me logo Genes that share pathways with ANO9: view

Pathways by source for ANO9 Gene

Interacting Proteins for ANO9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332788%0d%0a9606.ENSP00000345731%0d%0a
Selected Interacting proteins: ENSP00000332788 for ANO9 Gene via STRING

Symbol External ID(s) Details
DLG1

Gene Ontology (GO) - Biological Process for ANO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
GO:0061590 calcium activated phosphatidylcholine scrambling IEA --
GO:0061591 calcium activated galactosylceramide scrambling IEA --
genes like me logo Genes that share ontologies with ANO9: view

No data available for SIGNOR curated interactions for ANO9 Gene

Drugs & Compounds for ANO9 Gene

(1) Drugs for ANO9 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for ANO9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
genes like me logo Genes that share compounds with ANO9: view

Transcripts for ANO9 Gene

Unigene Clusters for ANO9 Gene

Anoctamin 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANO9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:

ExUns: 18b · 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ANO9 Gene

GeneLoc Exon Structure for
ANO9
ECgene alternative splicing isoforms for
ANO9

Expression for ANO9 Gene

mRNA expression in normal human tissues for ANO9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANO9 Gene

This gene is overexpressed in Colon - Transverse (x8.4), Small Intestine - Terminal Ileum (x7.4), Skin - Not Sun Exposed (Suprapubic) (x6.6), and Skin - Sun Exposed (Lower leg) (x6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANO9 Gene



SOURCE GeneReport for Unigene cluster for ANO9 Gene Hs.501622

genes like me logo Genes that share expression patterns with ANO9: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ANO9 Gene

Orthologs for ANO9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANO9 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ANO9 35
  • 83.26 (n)
  • 79.15 (a)
ANO9 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ano9 35
  • 77.61 (n)
  • 74.22 (a)
Ano9 16
Ano9 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ano9 35
  • 79.06 (n)
  • 76.93 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ANO9 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANO9 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANO9 35
  • 67.72 (n)
  • 60.55 (a)
ANO9 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANO9 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493850 35
  • 63.53 (n)
  • 59.4 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC559809 35
  • 57.65 (n)
  • 50.85 (a)
ANO9 (2 of 2) 36
  • 46 (a)
OneToMany
ano9a 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6938 36
  • 21 (a)
OneToMany
Species with no ortholog for ANO9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANO9 Gene

ENSEMBL:
Gene Tree for ANO9 (if available)
TreeFam:
Gene Tree for ANO9 (if available)

Paralogs for ANO9 Gene

Paralogs for ANO9 Gene

(7) SIMAP similar genes for ANO9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANO9: view

Variants for ANO9 Gene

Sequence variations from dbSNP and Humsavar for ANO9 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10794324 - 428,489(+) GATGA(C/G/T)GATGG nc-transcript-variant, reference, missense
rs10794323 - 428,385(+) CACGC(A/G)CCTGT nc-transcript-variant, reference, missense, splice-donor-variant
VAR_054621 -
rs61494944 -- 429,204(+) ACAGA(C/G)ACGGG intron-variant
rs7484182 -- 419,906(-) GGAGC(A/G)CAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANO9 Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv896463 CNV Gain 21882294
nsv527327 CNV Loss 19592680
dgv918n71 CNV Loss 21882294
dgv182e199 CNV Deletion 23128226
dgv919n71 CNV Loss 21882294
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
dgv924n71 CNV Loss 21882294
nsv467633 CNV Loss 19166990
nsv896502 CNV Loss 21882294
nsv469923 CNV Loss 18288195
dgv925n71 CNV Loss 21882294
nsv896514 CNV Gain 21882294
nsv896517 CNV Loss 21882294
nsv896518 CNV Gain+Loss 21882294
dgv927n71 CNV Loss 21882294
dgv928n71 CNV Gain+Loss 21882294
dgv929n71 CNV Loss 21882294
dgv930n71 CNV Loss 21882294
dgv931n71 CNV Loss 21882294
nsv896530 CNV Gain+Loss 21882294
nsv896532 CNV Gain 21882294
nsv896534 CNV Gain 21882294
essv23843 CNV CNV 17122850
esv1960258 CNV Deletion 18987734
esv3908 CNV Deletion 18987735
esv1003820 CNV Deletion 20482838
esv1030132 CNV Deletion 17803354
nsv825677 CNV Loss 20364138
esv2476569 CNV Deletion 19546169
esv3176 CNV Deletion 18987735
esv270933 CNV Insertion 20981092
esv273658 CNV Insertion 20981092
nsv8754 CNV Gain 18304495
esv32925 CNV Gain 17666407
esv29363 CNV Loss 19812545

Variation tolerance for ANO9 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ANO9 Gene

Disorders for ANO9 Gene

Relevant External Links for ANO9

Genetic Association Database (GAD)
ANO9
Human Genome Epidemiology (HuGE) Navigator
ANO9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANO9

No disorders were found for ANO9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANO9 Gene

Publications for ANO9 Gene

  1. Structure and function of TMEM16 proteins (anoctamins). (PMID: 24692353) Pedemonte N. … Galietta L.J. (Physiol. Rev. 2014) 2 3 67
  2. Identification and characterization of human TP53I5 and mouse Tp53i5 genes in silico. (PMID: 15202010) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 3 23
  3. A model for p53-induced apoptosis. (PMID: 9305847) Polyak K. … Vogelstein B. (Nature 1997) 2 3
  4. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PMID: 21984732) Scudieri P. … Galietta L.J. (Exp. Physiol. 2012) 3
  5. Common polymorphisms in the PKP3-SIGIRR-TMEM16J gene region are associated with susceptibility to tuberculosis. (PMID: 22223854) Horne D.J. … Hawn T.R. (J. Infect. Dis. 2012) 3

Products for ANO9 Gene

Sources for ANO9 Gene

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