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Aliases for ANO9 Gene

Aliases for ANO9 Gene

  • Anoctamin 9 2 3 5
  • Transmembrane Protein 16J 2 3 4
  • Tumor Protein P53-Inducible Protein 5 3 4
  • P53-Induced Gene 5 Protein 3 4
  • TMEM16J 3 4
  • TP53I5 3 4
  • PIG5 3 4
  • Tumor Protein P53 Inducible Protein 5 2
  • Anoctamin-9 3

External Ids for ANO9 Gene

Previous HGNC Symbols for ANO9 Gene

  • TP53I5
  • TMEM16J

Previous GeneCards Identifiers for ANO9 Gene

  • GC11M000409
  • GC11M000233
  • GC11M000418
  • GC11M000419
  • GC11M000420
  • GC11M000421

Summaries for ANO9 Gene

Entrez Gene Summary for ANO9 Gene

  • The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phospholipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. [provided by RefSeq, Dec 2016]

GeneCards Summary for ANO9 Gene

ANO9 (Anoctamin 9) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include intracellular calcium activated chloride channel activity and phospholipid scramblase activity. An important paralog of this gene is ANO4.

UniProtKB/Swiss-Prot for ANO9 Gene

  • Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANO9 Gene

Genomics for ANO9 Gene

Regulatory Elements for ANO9 Gene

Enhancers for ANO9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F000443 1.1 Ensembl ENCODE 12.1 -5.7 -5723 8.3 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 TSPAN4 ENSG00000255237 LRRC56 SNORA52 PHRF1 PTDSS2 ANO9 RNH1 ENSG00000255158 HRAS
GH11F000257 0.2 Ensembl 6.6 +184.5 184511 0.6 MTA2 NR2F1 TBX21 SP1 POLR2A EED IKZF1 TARDBP NBN NR2F6 RIC8A NLRP6 ENSG00000255026 PGGHG MIR6743 BET1L ANO9 COX8BP GC11P000259
GH11F000266 1 FANTOM5 Ensembl ENCODE 5.2 +172.0 171959 6.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A YY1 ZNF766 CBX5 ZNF143 RIC8A IFITM2 PHRF1 PSMD13 SNORA52 SIRT3 PGGHG ENSG00000255237 ENSG00000254559 ODF3
GH11F000311 1.5 FANTOM5 ENCODE 1.4 +127.1 127143 7.0 HDGF ATF1 PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A ARID4B ETS1 YY1 ENSG00000254910 IFITM3 PGGHG PHRF1 IFITM2 SNORA52 RIC8A ENSG00000251661 ENSG00000255026 NLRP6
GH11F000441 0.6 ENCODE 0.8 -0.1 -101 1.3 ELF3 TFAP4 KLF1 SAP130 ARID4B DMAP1 RELA POLR2A EED THAP11 RNH1 HRAS ANO9 PTDSS2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ANO9 on UCSC Golden Path with GeneCards custom track

Promoters for ANO9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000186948 11 801 ELF3 TFAP4 KLF1 SAP130 ARID4B DMAP1 RELA POLR2A EED THAP11

Genomic Location for ANO9 Gene

Chromosome:
11
Start:
417,930 bp from pter
End:
442,011 bp from pter
Size:
24,082 bases
Orientation:
Minus strand

Genomic View for ANO9 Gene

Genes around ANO9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANO9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANO9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANO9 Gene

Proteins for ANO9 Gene

  • Protein details for ANO9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A5B4-ANO9_HUMAN
    Recommended name:
    Anoctamin-9
    Protein Accession:
    A1A5B4
    Secondary Accessions:
    • B3KUC4
    • B4E134
    • Q8TEN4

    Protein attributes for ANO9 Gene

    Size:
    782 amino acids
    Molecular mass:
    90333 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The term anoctamin was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
    SequenceCaution:
    • Sequence=BAB84914.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANO9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANO9 Gene

Post-translational modifications for ANO9 Gene

  • Glycosylation at Asn 641, Asn 652, Asn 674, and Asn 690
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANO9 Gene

Domains & Families for ANO9 Gene

Gene Families for ANO9 Gene

Protein Domains for ANO9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANO9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1A5B4

UniProtKB/Swiss-Prot:

ANO9_HUMAN :
  • Belongs to the anoctamin family.
Family:
  • Belongs to the anoctamin family.
genes like me logo Genes that share domains with ANO9: view

Function for ANO9 Gene

Molecular function for ANO9 Gene

UniProtKB/Swiss-Prot Function:
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.

Gene Ontology (GO) - Molecular Function for ANO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005229 intracellular calcium activated chloride channel activity TAS --
GO:0017128 phospholipid scramblase activity IEA --
genes like me logo Genes that share ontologies with ANO9: view
genes like me logo Genes that share phenotypes with ANO9: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ANO9

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANO9 Gene

Localization for ANO9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANO9 Gene

Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANO9 Gene COMPARTMENTS Subcellular localization image for ANO9 gene
Compartment Confidence
plasma membrane 5
peroxisome 2

Gene Ontology (GO) - Cellular Components for ANO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANO9: view

Pathways & Interactions for ANO9 Gene

genes like me logo Genes that share pathways with ANO9: view

Pathways by source for ANO9 Gene

Interacting Proteins for ANO9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332788%0d%0a9606.ENSP00000345731%0d%0a
Selected Interacting proteins: A1A5B4-ANO9_HUMAN ENSP00000332788 for ANO9 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ANO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006821 chloride transport IMP 22946059
GO:0006869 lipid transport IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0061588 calcium activated phospholipid scrambling IEA --
genes like me logo Genes that share ontologies with ANO9: view

No data available for SIGNOR curated interactions for ANO9 Gene

Drugs & Compounds for ANO9 Gene

(1) Drugs for ANO9 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for ANO9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
genes like me logo Genes that share compounds with ANO9: view

Transcripts for ANO9 Gene

Unigene Clusters for ANO9 Gene

Anoctamin 9:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ANO9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANO9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:

ExUns: 18b · 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ANO9 Gene

GeneLoc Exon Structure for
ANO9
ECgene alternative splicing isoforms for
ANO9

Expression for ANO9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANO9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANO9 Gene

This gene is overexpressed in Colon - Transverse (x8.4), Small Intestine - Terminal Ileum (x7.4), Skin - Not Sun Exposed (Suprapubic) (x6.6), and Skin - Sun Exposed (Lower leg) (x6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANO9 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANO9 Gene:

ANO9

SOURCE GeneReport for Unigene cluster for ANO9 Gene:

Hs.501622
genes like me logo Genes that share expression patterns with ANO9: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ANO9 Gene

Orthologs for ANO9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANO9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANO9 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANO9 34 35
  • 83.26 (n)
rat
(Rattus norvegicus)
Mammalia Ano9 34
  • 79.06 (n)
mouse
(Mus musculus)
Mammalia Ano9 34 16 35
  • 77.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANO9 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANO9 34 35
  • 67.72 (n)
lizard
(Anolis carolinensis)
Reptilia ANO9 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493850 34
  • 63.53 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC559809 34
  • 57.65 (n)
ANO9 (2 of 2) 35
  • 46 (a)
OneToMany
ano9a 35
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6938 35
  • 21 (a)
OneToMany
Species where no ortholog for ANO9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANO9 Gene

ENSEMBL:
Gene Tree for ANO9 (if available)
TreeFam:
Gene Tree for ANO9 (if available)

Paralogs for ANO9 Gene

Paralogs for ANO9 Gene

(7) SIMAP similar genes for ANO9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANO9: view

Variants for ANO9 Gene

Sequence variations from dbSNP and Humsavar for ANO9 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs193920739 Uncertain significance 418,804(-) AGGGA(C/G)TACCG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs10331 -- 418,179(+) GCCTG(A/C)GAGCC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs10707508 -- 436,084(+) TTTTT(-/T)GAGAC intron-variant
rs10751658 -- 437,401(+) CCCTG(C/G)GGGGG intron-variant, nc-transcript-variant
rs10751659 -- 437,559(+) GTGGC(C/T)TGCCA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ANO9 Gene

Variant ID Type Subtype PubMed ID
dgv1012n100 CNV gain 25217958
dgv1505n54 CNV gain 21841781
dgv1517n54 CNV gain 21841781
dgv1518n54 CNV loss 21841781
dgv1519n54 CNV gain+loss 21841781
dgv1520n54 CNV gain 21841781
dgv1521n54 CNV loss 21841781
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv1003820 CNV deletion 20482838
esv1030132 CNV deletion 17803354
esv1960258 CNV deletion 18987734
esv2476569 CNV deletion 19546169
esv2759794 CNV loss 17122850
esv29363 CNV loss 19812545
esv3176 CNV loss 18987735
esv32925 CNV gain 17666407
esv3547173 CNV deletion 23714750
esv3891907 CNV loss 25118596
esv3908 CNV loss 18987735
nsv1069988 CNV deletion 25765185
nsv1069989 CNV deletion 25765185
nsv1070919 CNV deletion 25765185
nsv1077764 OTHER inversion 25765185
nsv1122577 CNV deletion 24896259
nsv1125519 CNV tandem duplication 24896259
nsv1130652 CNV deletion 24896259
nsv1136120 CNV deletion 24896259
nsv1143666 CNV deletion 24896259
nsv1143667 CNV deletion 24896259
nsv1148385 CNV deletion 26484159
nsv1159790 CNV deletion 26073780
nsv467633 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv527327 CNV loss 19592680
nsv552770 CNV gain 21841781
nsv552776 CNV loss 21841781
nsv552825 CNV gain+loss 21841781
nsv552826 CNV gain 21841781
nsv552827 CNV loss 21841781
nsv552828 CNV gain 21841781
nsv552829 CNV gain 21841781
nsv552830 CNV gain+loss 21841781
nsv552831 CNV gain 21841781
nsv552846 CNV gain 21841781
nsv552852 CNV loss 21841781
nsv825677 CNV loss 20364138
nsv8754 CNV gain 18304495
nsv951268 CNV deletion 24416366
nsv957843 CNV deletion 24416366

Variation tolerance for ANO9 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANO9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANO9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANO9 Gene

Disorders for ANO9 Gene

Relevant External Links for ANO9

Genetic Association Database (GAD)
ANO9
Human Genome Epidemiology (HuGE) Navigator
ANO9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANO9

No disorders were found for ANO9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANO9 Gene

Publications for ANO9 Gene

  1. Structure and function of TMEM16 proteins (anoctamins). (PMID: 24692353) Pedemonte N. … Galietta L.J. (Physiol. Rev. 2014) 2 3 64
  2. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PMID: 21984732) Scudieri P. … Galietta L.J. (Exp. Physiol. 2012) 3 4 64
  3. Anoctamins are a family of Ca2+ activated Cl- channels. (PMID: 22946059) Tian Y. … Kunzelmann K. (J. Cell Sci. 2012) 3 4 64
  4. CFTR and TMEM16A are separate but functionally related Cl-channels. (PMID: 22178883) Ousingsawat J. … Kunzelmann K. (Cell. Physiol. Biochem. 2011) 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for ANO9 Gene

Sources for ANO9 Gene

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