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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANO8 Gene

protein-coding GIFtS: 49
GCID: GC19M017434

anoctamin 8

(Previous names: KIAA1623, transmembrane protein 16H )
(Previous symbols: KIAA1623, TMEM16H)

Search for ANO8
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Anoctamin 8¹ ²		Anoctamin-8¹
KIAA1623¹ ² ³ ⁵		EC 5.4.2.10⁸
TMEM16H¹ ² ³ ⁵		EC 6.1.1⁸
Transmembrane Protein 16H¹ ² ³

External Ids:	HGNC: 29329¹	Entrez Gene: 57719²	Ensembl: ENSG00000074855⁷	OMIM: 610216⁵	UniProtKB: Q9HCE9³

Export aliases for ANO8 gene to outside databases

Previous GC identifers: GC19M017299 GC19M017000

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ANO8_HUMAN, Q9HCE9

Function: Does not exhibit calcium-activated chloride channel (CaCC) activity

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANO8 gene promoter:
E2F-4 E2F-3a E2F-5 Olf-1 Nkx2-5 E2F-2 E2F E2F-1 FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANO8 promoter sequence

Search SABiosciences Chromatin IP Primers for ANO8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANO8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.12

ANO8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANO8 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M017434: view genomic region (about GC identifiers)

Start:	17,434,032 bp from pter	End:	17,445,638 bp from pter
Size:	11,607 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANO8_HUMAN, Q9HCE9 (See protein sequence)

Recommended Name: Anoctamin-8

Size: 1232 amino acids; 136034 Da

Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular

localization with a weak expression in the cell membrane

Miscellaneous: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)

transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain

that all the members of this family are anion channels or have the 8-transmembrane topology

Sequence caution: Sequence=BAB13449.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: A6NIJ0

Alternative splicing: 2 isoforms: Q9HCE9-1 Q9HCE9-2

Explore the universe of human proteins at neXtProt for ANO8: NX_Q9HCE9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HCE9

2 DME Specific Peptides for ANO8 (Q9HCE9)

GATSSLA

ARPDGTP

ANO8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_066010.1

ENSEMBL proteins:

ENSP00000159087

Reactome Protein details: Q9HCE9
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	GenScript Custom Purified and Recombinant Proteins Services for ANO8
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ANO8

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0034707	chloride channel complex	--	--

ANO8 for ontologies About GeneDecksing

ANO8 Antibody Products:

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	Novus Biologicals ANO8 Antibody
	Search for Antibodies for ANO8 at Abcam
	Uscn Antibodies for ANO8
	Search ThermoFisher Antibodies for ANO8

Assay Products for ANO8:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ANO8
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ANO8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANO8 for domains About GeneDecksing

1 InterPro domain/family:

IPR007632 Anoctamin

Graphical View of Domain Structure for InterPro Entry Q9HCE9

ProtoNet protein and cluster: Q9HCE9

UniProtKB/Swiss-Prot: ANO8_HUMAN, Q9HCE9

Similarity: Belongs to the anoctamin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ANO8_HUMAN, Q9HCE9

Function: Does not exhibit calcium-activated chloride channel (CaCC) activity

Enzyme Numbers (IUBMB): EC 5.4.2.10² EC 6.1.1²

miRNA Products:		OriGene 3'-UTR Clone: ANO8 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANO8
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ANO8 (see all 23):
		hsa-miR-448 hsa-miR-137 hsa-miR-520d-5p hsa-miR-25 hsa-miR-7-1* hsa-miR-548x hsa-miR-1208 hsa-miR-33b

		SwitchGear 3'UTR luciferase reporter plasmid: ANO8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANO8 OriGene shRNA RFP: ANO8 OriGene siRNA: ANO8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANO8

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ANO8

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANO8 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANO8 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ANO8 (NM_020959)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANO8
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANO8

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ANO8
		Search LifeMap BioReagents cell lines for ANO8

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO8

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005229	NOT intracellular calcium activated chloride channel activity	IDA	--
GO:0005254	chloride channel activity	--	--

ANO8 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ion channel transport

Ion channel transport

1.00

Stimuli-sensing channels

0.49

SLC-mediated transmembrane transport

Transmembrane transport of small molecules

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for ANO8

	Transmembrane transport of small molecules
	Stimuli-sensing channels
	Ion channel transport

ANO8 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ANO8

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for ANO8 (Q9HCE9³ ENSP00000159087⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COQ9	O75208³, ENSP00000262507⁴	I2D: score=3 STRING: ENSP00000262507
APC	P25054³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANO8

2 HMDB Compounds for ANO8 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Chlorine	Cl2 (see all 13)	16887-00-6	--

Search CenterWatch for drugs/clinical trials and news about ANO8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ANO8 gene:

NM_020959.2

Unigene Cluster for ANO8:

Anoctamin 8

Hs.590990 [show with all ESTs]

Unigene Representative Sequence: BC037307

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000159087(uc002ngf.2 uc010eap.2)

miRNA Products:		OriGene 3'-UTR Clone: ANO8 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANO8
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ANO8 (see all 23):
		hsa-miR-448 hsa-miR-137 hsa-miR-520d-5p hsa-miR-25 hsa-miR-7-1* hsa-miR-548x hsa-miR-1208 hsa-miR-33b

		SwitchGear 3'UTR luciferase reporter plasmid: ANO8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANO8 OriGene shRNA RFP: ANO8 OriGene siRNA: ANO8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANO8

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANO8 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANO8 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ANO8 (NM_020959)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANO8
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANO8

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANO8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ANO8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANO8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANO8

Additional cDNA sequence:

AB046843.2 BC037307.1

5 DOTS entries:

DT.91732791 DT.446827 DT.95242677 DT.100805542 DT.121465064

19 AceView cDNA sequences:

CR616031 AB046843 BX444991 BC037307 BX419957 BU159689 BQ941716 BX444990

BI054298 BX282591 BI548250 BF945362 AI860149 AW090503 BF957825 BU192457

BF363458 AW151476 BF852719

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ANO8 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11
SP1:
SP2:							-
SP3:
SP4:

ECgene alternative splicing isoforms for ANO8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANO8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGGGCCCC

About this image

ANO8 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ANO8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANO8

SOURCE GeneReport for Unigene cluster: Hs.590990

UniProtKB/Swiss-Prot: ANO8_HUMAN, Q9HCE9

Tissue specificity: Expressed in embryonic stem cells, fetal brain and neural tissues

SABiosciences Custom PCR Arrays for ANO8

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANO8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANO8

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANO8 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ano8^{1 , 5}	anoctamin 8^{1, 5}	82.15(n)¹ 88.32(a)¹		8 (34.43 cM)⁵ 382014¹ NM_001164679.1¹ NP_001158151.1¹ 71476023⁵
chicken (Gallus gallus)	Aves	ANO8¹	anoctamin 8	72.99(n) 72.37(a)		429912 XM_427467.3 XP_427467.3
zebrafish (Danio rerio)	Actinopterygii	ano8¹	anoctamin 8	66.12(n) 66.7(a)		562782 XM_686156.5 XP_691248.5
fruit fly (Drosophila melanogaster)	Insecta	CG15270⁶	--	24(a)	1 ↔ 1	2L(15074776-15096915)
worm (Caenorhabditis elegans)	Secernentea	anoh-2¹	Protein ANOH-2	49.01(n) 45.26(a)		178395 NM_182301.3 NP_872101.3
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G73020⁶	uncharacterized protein	20(a)	1 → many	1(27469534-27473554)
rice (Oryza sativa)	Liliopsida	--	transmembrane protein 16K, putative, expressed	21(a)	1 → many	1(29317147-29321524)

ENSEMBL Gene Tree for ANO8 (if available)
TreeFam Gene Tree for ANO8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANO8 gene

ANO9² ANO6² ANO2² ANO5² ANO1² ANO10² ANO4² ANO3²

ANO7²

ANO8 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115755445^1,2	C,F,	--	17012047(+)	`GCTCGC/ACCGAG`	1	--	us2k¹		1		WA	118
rs12976513^1,2	C	--	17012085(+)	`AACCTC/AGATTC`	1	--	us2k¹		1		NA	2
rs73511900^1,2	C,	--	17012120(+)	`CTCTAG/AGGTTC`	1	--	us2k¹		2		WA	120
rs113983944^1,2	C,	--	17012467(+)	`CAAGCA/CCTGCT`	1	--	int¹		0	--	--	--	--
rs34038210^1,2	C	--	17012502(+)	`GCTGCC/TTAGAA`	1	--	int¹		1		NA	2
rs111520147^1,2	C,	--	17012727(+)	`GAGGTC/TAAGGC`	1	--	int¹		2		WA	120
rs113375234^1,2	C,	--	17013357(+)	`GGCATG/AGTGGC`	4	--	us2k¹ int¹		1		NA	2
rs56103652^1,2	F,	--	17013544(+)	`ATCCCC/TGTCTC`	4	--	int¹ us2k¹		1		WA	118
rs113276380^1,2	C,	--	17013875(+)	`GCGCCG/TCCCGC`	4	--	int¹ us2k¹		1		NA	2
rs144096287^1,2		--	17433534(+)	`CCACCC/TCGTGT`	2	--	ut3¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ANO8 (17434032 - 17445638 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ANO8
2 CNVs: 67488 39226

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANO8

DNA2.0 Custom Variant and Variant Library Synthesis for ANO8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANO8 for disorders About MalaCards

ANO8 for disorders About GeneDecksing

OMIM gene information: 610216 OMIM disorders: --

Export disorders for ANO8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANO8 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with ANO8)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)^{1, 2, 3} Nagase T.... Ohara O. (2000)
Identification and characterization of TMEM16H gene in silico. (PubMed id 15647853)^{1, 2, 9} Katoh M. and Katoh M. (2005)
Anoctamins are a family of Ca2+ activated Cl- channels. (PubMed id 22946059)² Tian Y.... Kunzelmann K. (2012)
The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age. (PubMed id 22302790)² Winpenny J.P. and Gray M.A. (2012)
The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PubMed id 21984732)² Scudieri P.... Galietta L.J. (2012)
CFTR and TMEM16A are separate but functionally related Cl- channels. (PubMed id 22178883)² Ousingsawat J....Kunzelmann K. (2011)
Anoctamins. (PubMed id 21607626)² Kunzelmann K.... Schreiber R. (2011)
Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels? (PubMed id 21642943)² Duran C. and Hartzell H.C. (2011)
Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels. (PubMed id 19015192)¹ Hartzell H.C....Qu Z. (2009)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57719	HGNC: 29329	AceView: KIAA1623	Ensembl:ENSG00000074855	euGenes: HUgn57719
ECgene: ANO8	H-InvDB: ANO8

(According to HUGE)
About This Section

HUGE: KIAA1623

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANO8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANO8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ANO8 gene:
Search GeneIP for patents involving ANO8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		OriGene shRNA RFP for ANO8
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANO8		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANO8
	OriGene Protein Over-expression Lysate for ANO8		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ANO8		OriGene 3'-UTR Clone for ANO8
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	OriGene Custom Antibody Services for ANO8		OriGene Custom Protein Services for ANO8
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANO8
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANO8
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANO8
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANO8
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANO8
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANO8

	GenScript Custom Purified and Recombinant Proteins Services for ANO8		GenScript cDNA clones with any tag delivered in your preferred vector for ANO8
	GenScript Custom Assay Services for ANO8		GenScript Custom Superior Antibodies Services for ANO8
	GenScript Custom overexpressing Cell Line Services for ANO8		CloneReady with Over 120,000 Genes
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO8

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Search ThermoFisher Antibodies for ANO8

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANO8

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ANO8 gene at Home site.

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ANO8 Gene

anoctamin 8

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ANO8 Gene

anoctamin 8

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Genomic Viewsfor ANO8 gene

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Protein Domains /Familiesfor ANO8 gene

Functionfor ANO8 gene

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Expression
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