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Aliases for ANO8 Gene

Aliases for ANO8 Gene

  • Anoctamin 8 2 3 5
  • Transmembrane Protein 16H 2 3 4
  • KIAA1623 2 3 4
  • TMEM16H 3 4
  • EC 63
  • EC 6.1.1 63

External Ids for ANO8 Gene

Previous HGNC Symbols for ANO8 Gene

  • KIAA1623
  • TMEM16H

Previous GeneCards Identifiers for ANO8 Gene

  • GC19M017299
  • GC19M017434
  • GC19M017000

Summaries for ANO8 Gene

GeneCards Summary for ANO8 Gene

ANO8 (Anoctamin 8) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include intracellular calcium activated chloride channel activity. An important paralog of this gene is ANO5.

UniProtKB/Swiss-Prot for ANO8 Gene

  • Does not exhibit calcium-activated chloride channel (CaCC) activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANO8 Gene

Genomics for ANO8 Gene

Regulatory Elements for ANO8 Gene

Enhancers for ANO8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANO8 on UCSC Golden Path with GeneCards custom track

Promoters for ANO8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANO8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANO8 Gene

17,323,223 bp from pter
17,334,834 bp from pter
11,612 bases
Minus strand

Genomic View for ANO8 Gene

Genes around ANO8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANO8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANO8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANO8 Gene

Proteins for ANO8 Gene

  • Protein details for ANO8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NIJ0

    Protein attributes for ANO8 Gene

    1232 amino acids
    Molecular mass:
    136034 Da
    Quaternary structure:
    No Data Available
    • The term anoctamin was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
    • Sequence=BAB13449.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANO8 Gene


neXtProt entry for ANO8 Gene

Proteomics data for ANO8 Gene at MOPED

Selected DME Specific Peptides for ANO8 Gene

Post-translational modifications for ANO8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANO8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ANO8 Gene

Gene Families for ANO8 Gene

Protein Domains for ANO8 Gene


Suggested Antigen Peptide Sequences for ANO8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the anoctamin family.
  • Belongs to the anoctamin family.
genes like me logo Genes that share domains with ANO8: view

Function for ANO8 Gene

Molecular function for ANO8 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit calcium-activated chloride channel (CaCC) activity.

Enzyme Numbers (IUBMB) for ANO8 Gene

genes like me logo Genes that share phenotypes with ANO8: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANO8 Gene

Localization for ANO8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANO8 Gene

Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.

Subcellular locations from

Jensen Localization Image for ANO8 Gene COMPARTMENTS Subcellular localization image for ANO8 gene
Compartment Confidence
plasma membrane 5
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for ANO8 Gene

Pathways & Interactions for ANO8 Gene

genes like me logo Genes that share pathways with ANO8: view

Pathways by source for ANO8 Gene

Gene Ontology (GO) - Biological Process for ANO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with ANO8: view

No data available for SIGNOR curated interactions for ANO8 Gene

Drugs & Compounds for ANO8 Gene

(1) Drugs for ANO8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for ANO8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
genes like me logo Genes that share compounds with ANO8: view

Transcripts for ANO8 Gene

mRNA/cDNA for ANO8 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANO8 Gene

Anoctamin 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANO8 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP2: -

Relevant External Links for ANO8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANO8 Gene

mRNA expression in normal human tissues for ANO8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANO8 Gene

This gene is overexpressed in Pancreas (58.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANO8 Gene

SOURCE GeneReport for Unigene cluster for ANO8 Gene Hs.590990

mRNA Expression by UniProt/SwissProt for ANO8 Gene

Tissue specificity: Expressed in embryonic stem cells, fetal brain and neural tissues.
genes like me logo Genes that share expression patterns with ANO8: view

Protein tissue co-expression partners for ANO8 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for ANO8 Gene

Orthologs for ANO8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANO8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANO8 35
  • 85.04 (n)
  • 88.11 (a)
ANO8 36
  • 90 (a)
(Canis familiaris)
Mammalia ANO8 35
  • 89.09 (n)
  • 93.12 (a)
ANO8 36
  • 94 (a)
(Mus musculus)
Mammalia Ano8 35
  • 82.08 (n)
  • 87.94 (a)
Ano8 16
Ano8 36
  • 88 (a)
(Pan troglodytes)
Mammalia ANO8 35
  • 97.48 (n)
  • 97.39 (a)
ANO8 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ano8 35
  • 81.61 (n)
  • 86.61 (a)
(Monodelphis domestica)
Mammalia ANO8 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia ANO8 36
  • 71 (a)
(Gallus gallus)
Aves ANO8 35
  • 73.64 (n)
  • 72.81 (a)
-- 36
  • 63 (a)
-- 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ano8 35
  • 64.58 (n)
  • 66.11 (a)
(Danio rerio)
Actinopterygii ano8 35
  • 66.67 (n)
  • 67.09 (a)
ANO8 36
  • 62 (a)
ano8a 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15270 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea anoh-2 35
  • 48.38 (n)
  • 44.84 (a)
anoh-2 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for ANO8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANO8 Gene

Gene Tree for ANO8 (if available)
Gene Tree for ANO8 (if available)

Paralogs for ANO8 Gene

Paralogs for ANO8 Gene

genes like me logo Genes that share paralogs with ANO8: view

Variants for ANO8 Gene

Sequence variations from dbSNP and Humsavar for ANO8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8102944 -- 17,327,833(+) AGCAC(A/G)ACGTA nc-transcript-variant, reference, synonymous-codon
rs12984306 -- 17,324,215(+) TGGTG(A/G)GGGTG intron-variant, nc-transcript-variant
rs13345139 -- 17,324,224(+) tggga(C/G)ggtag intron-variant, nc-transcript-variant
rs67372672 -- 17,324,073(+) CGSCC(-/C)CTGCC intron-variant, nc-transcript-variant
rs71180396 -- 17,331,952(+) TTTTT(-/TTT)AGACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANO8 Gene

Variant ID Type Subtype PubMed ID
dgv3758n71 CNV Loss 21882294
nsv911182 CNV Loss 21882294
nsv470129 CNV Loss 18288195
dgv3760n71 CNV Loss 21882294
nsv911198 CNV Loss 21882294
nsv911200 CNV Loss 21882294
esv21604 CNV Gain 19812545

Variation tolerance for ANO8 Gene

Residual Variation Intolerance Score: 5.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ANO8 Gene

Disorders for ANO8 Gene

Relevant External Links for ANO8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANO8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANO8 Gene

Publications for ANO8 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Structure and function of TMEM16 proteins (anoctamins). (PMID: 24692353) Pedemonte N. … Galietta L.J. (Physiol. Rev. 2014) 2 3
  3. Identification and characterization of TMEM16H gene in silico. (PMID: 15647853) Katoh M. … Katoh M. (Int. J. Mol. Med. 2005) 3 23
  4. Genetics of rheumatoid arthritis contributes to biology and drug discovery. (PMID: 24390342) Okada Y. … Plenge R.M. (Nature 2013) 3
  5. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PMID: 21984732) Scudieri P. … Galietta L.J. (Exp. Physiol. 2012) 3

Products for ANO8 Gene

Sources for ANO8 Gene