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ANO8 Gene

protein-coding   GIFtS: 48
GCID: GC19M017434

Anoctamin 8

(Previous names: KIAA1623, transmembrane protein 16H)
(Previous symbols: KIAA1623, TMEM16H)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Anoctamin 81 2     anoctamin-82
KIAA16231 2 3 5     EC 5.4.2.108
TMEM16H1 2 3 5     EC 6.1.18
Transmembrane Protein 16H1 2 3     

External Ids:    HGNC: 293291   Entrez Gene: 577192   Ensembl: ENSG000000748557   OMIM: 6102165   UniProtKB: Q9HCE93   

Export aliases for ANO8 gene to outside databases

Previous GC identifers: GC19M017299 GC19M017000


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANO8 Gene:
ANO8 (anoctamin 8) is a protein-coding gene. GO annotations related to this gene include intracellular calcium activated chloride channel activity. An important paralog of this gene is ANO9.

UniProtKB/Swiss-Prot: ANO8_HUMAN, Q9HCE9
Function: Does not exhibit calcium-activated chloride channel (CaCC) activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANO8 gene promoter:
         E2F-4   E2F-3a   E2F-5   Olf-1   Nkx2-5   E2F-2   E2F   E2F-1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANO8 promoter sequence
   Search Chromatin IP Primers for ANO8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANO8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.12

ANO8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANO8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M017434:  view genomic region     (about GC identifiers)

Start:
17,434,032 bp from pter      End:
17,445,638 bp from pter
Size:
11,607 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANO8_HUMAN, Q9HCE9 (See protein sequence)
Recommended Name: Anoctamin-8  
Size: 1232 amino acids; 136034 Da
Miscellaneous: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)
transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not
certain that all the members of this family are anion channels or have the 8-transmembrane topology
Sequence caution: Sequence=BAB13449.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NIJ0
Alternative splicing: 2 isoforms:  Q9HCE9-1   Q9HCE9-2   

Explore the universe of human proteins at neXtProt for ANO8: NX_Q9HCE9

Explore proteomics data for ANO8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ANO8 (Q9HCE9)
     GATSSLA  ARPDGTP 


    See ANO8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066010.1  
    ENSEMBL proteins: 
     ENSP00000469751   ENSP00000159087  
    Reactome Protein details: Q9HCE9

    ANO8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for ANO8
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANO8

     
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    Search antibodies-online for proteins for ANO8 

     
    Search antibodies-online for peptides for ANO8

    ANO8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals ANO8 Antibody
    Abcam antibodies for ANO8
    Cloud-Clone Corp. Antibodies for ANO8
    Search ThermoFisher Antibodies for ANO8
    antibodies-online antibodies for ANO8 (3 products) 

    ANO8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ANO8
    Cloud-Clone Corp. CLIAs for ANO8
    Search eBioscience for ELISAs for ANO8 
    antibodies-online kits for ANO8 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANO: Ion channels / Chloride channels : Calcium activated : Anoctamins

    1 InterPro protein domain:
     IPR007632 Anoctamin

    Graphical View of Domain Structure for InterPro Entry Q9HCE9

    ProtoNet protein and cluster: Q9HCE9

    UniProtKB/Swiss-Prot: ANO8_HUMAN, Q9HCE9
    Similarity: Belongs to the anoctamin family


    Find genes that share domains with ANO8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANO8_HUMAN, Q9HCE9
    Function: Does not exhibit calcium-activated chloride channel (CaCC) activity

         Enzyme Numbers (IUBMB): EC 5.4.2.102 EC 6.1.12

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005229NOT intracellular calcium activated chloride channel activity IDA--
         
    Find genes that share ontologies with ANO8           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANO8

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANO8:
    hsa-mir-32-5p (MIRT028358)

    Block miRNA regulation of human, mouse, rat ANO8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANO8 (see all 23):
    hsa-miR-448 hsa-miR-137 hsa-miR-520d-5p hsa-miR-25 hsa-miR-7-1* hsa-miR-548x hsa-miR-1208 hsa-miR-33b
    SwitchGear 3'UTR luciferase reporter plasmidANO8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANO8
    Predesigned siRNA for gene silencing in human, mouse, rat ANO8

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ANO8

    Clone
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    OriGene clones in human, mouse for ANO8 (see all 6)
    OriGene ORF clones in mouse, rat for ANO8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANO8 (NM_020959)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANO8
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANO8

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    Browse ESI BIO Cell Lines and PureStem Progenitors for ANO8 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANO8_HUMAN, Q9HCE9: Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular
    localization with a weak expression in the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ANO8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANO8 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with ANO8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ANO8
        Stimuli-sensing channels


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANO8
    Interactions:

        Search GeneGlobe Interaction Network for ANO8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ANO8 (Q9HCE93 ENSP000001590874) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COQ9O752083, ENSP000002625074I2D: score=3 STRING: ENSP00000262507
    APCP250543I2D: score=1 
    GTF2BENSP000003595314STRING: ENSP00000359531
    UBE2IENSP000003248974STRING: ENSP00000324897
    CLN3ENSP000003530734STRING: ENSP00000353073
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with ANO8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANO8

    2 HMDB Compounds for ANO8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANO8 gene: 
    NM_020959.2  

    Unigene Cluster for ANO8:

    Anoctamin 8
    Hs.590990  [show with all ESTs]
    Unigene Representative Sequence: BC037307
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000597643 ENST00000159087(uc002ngf.2 uc010eap.2) ENST00000600711

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ANO8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANO8 (see all 23):
    hsa-miR-448 hsa-miR-137 hsa-miR-520d-5p hsa-miR-25 hsa-miR-7-1* hsa-miR-548x hsa-miR-1208 hsa-miR-33b
    SwitchGear 3'UTR luciferase reporter plasmidANO8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ANO8
    Predesigned siRNA for gene silencing in human, mouse, rat ANO8
    Clone
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    OriGene clones in human, mouse for ANO8 (see all 6)
    OriGene ORF clones in mouse, rat for ANO8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANO8 (NM_020959)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANO8
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ANO8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANO8
      QuantiTect SYBR Green Assays in human, mouse, rat ANO8
      QuantiFast Probe-based Assays in human, mouse, rat ANO8

    Additional mRNA sequence: 

    AB046843.2 BC037307.1 

    5 DOTS entries:

    DT.91732791  DT.446827  DT.95242677  DT.100805542  DT.121465064 

    19 AceView cDNA sequences:

    BX444991 CR616031 AB046843 BX444990 BX419957 BC037307 BQ941716 BU159689 
    BI054298 BF945362 AI860149 BI548250 AW090503 BX282591 BF957825 BU192457 
    BF363458 AW151476 BF852719 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ANO8    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                        
    SP2:                    -                                                   
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for ANO8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANO8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGGGCCCC
    ANO8 Expression
    About this image


    ANO8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    ANO8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANO8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.590990

    UniProtKB/Swiss-Prot: ANO8_HUMAN, Q9HCE9
    Tissue specificity: Expressed in embryonic stem cells, fetal brain and neural tissues

        Custom PCR Arrays for ANO8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANO8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANO8 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ano81 , 5 anoctamin 81, 5 82.08(n)1
    87.94(a)1
      8 (34.43 cM)5
    3820141  NM_001164679.11  NP_001158151.11 
     714760235 
    chicken
    (Gallus gallus)
    Aves ANO81 anoctamin 8 73.64(n)
    72.81(a)
      429912  XM_427467.4  XP_427467.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ano81 anoctamin 8 64.58(n)
    66.11(a)
      100491780  XM_004911016.1  XP_004911073.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ano81 anoctamin 8 66.67(n)
    67.09(a)
      562782  XM_686156.6  XP_691248.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG152706
    --
    29(a)
    1 ↔ 1
    2L(15074776-15096915)
    worm
    (Caenorhabditis elegans)
    Secernentea anoh-21 anoh-2 48.38(n)
    44.84(a)
      178395  NM_001268891.1  NP_001255820.1 


    ENSEMBL Gene Tree for ANO8 (if available)
    TreeFam Gene Tree for ANO8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANO8 gene
    ANO92  ANO62  ANO22  ANO12  ANO52  ANO102  ANO32  ANO42  
    ANO72  

    Find genes that share paralogs with ANO8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANO8 (see all 261)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs673726721,2
    C--17434882(+) GCCCTC/-GCCGG 1 -- int11Minor allele frequency- -:0.00NA 2
    rs133451391,2
    C,F--17435033(+) tgggaG/Cggtag 1 -- int14Minor allele frequency- C:0.31CSA WA NA 241
    rs1995234161,2
    C--17435547(+) GGGCCA/GGGGGG 2 R W mis10--------
    rs2020376781,2
    --17435578(+) GCCTCA/GTCCAC 2 D syn10--------
    rs1508185571,2
    C,F--17435647(+) TGCCCG/ACCCGC 2 /G syn12Minor allele frequency- A:0.00NA EU 3893
    rs1436964491,2
    C,F--17435651(+) CGCCCG/ACCCCG 2 /A /V mis12Minor allele frequency- A:0.00NA EU 4019
    rs774368321,2
    C,F--17435665(+) GACCCA/CGGCTC 2 P syn11Minor allele frequency- C:0.01NA 3578
    rs2004660801,2
    --17435675(+) CAGCCC/TGGGTG 2 Q R mis10--------
    rs7551241,2
    C,F,A,H--17435851(-) GGGGCC/AGGAGC 2 /A syn1 ese316Minor allele frequency- A:0.07MN NS EA NA EU 6800
    rs7551231,2
    C,F,A,H--17435884(-) TCGTCG/AGGGGC 2 /S syn1 ese319Minor allele frequency- A:0.26MN NS EA NA WA CSA EU 6426

    HapMap Linkage Disequilibrium report for ANO8 (17434032 - 17445638 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ANO8:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3760n71CNV Loss21882294
    nsv911182CNV Loss21882294
    nsv911200CNV Loss21882294
    nsv911198CNV Loss21882294
    nsv470129CNV Loss18288195
    dgv3758n71CNV Loss21882294
    esv21604CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANO8
    DNA2.0 Custom Variant and Variant Library Synthesis for ANO8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610216    OMIM disorders: --


    Find genes that share disorders with ANO8           About GenesLikeMe


    Export disorders for ANO8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANO8 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ANO8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Identification and characterization of TMEM16H gene in silico. (PubMed id 15647853)1, 2, 9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2005)
    3. Anoctamins are a family of Ca2+ activated Cl- channels. (PubMed id 22946059)2 Tian Y.... Kunzelmann K. (J. Cell Sci. 2012)
    4. The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age. (PubMed id 22302790)2 Winpenny J.P. and Gray M.A. (Exp. Physiol. 2012)
    5. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PubMed id 21984732)2 Scudieri P.... Galietta L.J. (Exp. Physiol. 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. CFTR and TMEM16A are separate but functionally related Cl-channels. (PubMed id 22178883)2 Ousingsawat J.... Kunzelmann K. (Cell. Physiol. Biochem. 2011)
    8. Anoctamins. (PubMed id 21607626)2 Kunzelmann K.... Schreiber R. (Pflugers Arch. 2011)
    9. Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels? (PubMed id 21642943)2 Duran C. and Hartzell H.C. (Acta Pharmacol. Sin. 2011)
    10. Expression and function of epithelial anoctamins. (PubMed id 20056604)2 Schreiber R.... Kunzelmann K. (J. Biol. Chem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57719 HGNC: 29329 AceView: KIAA1623 Ensembl:ENSG00000074855 euGenes: HUgn57719
    ECgene: ANO8 H-InvDB: ANO8

    (According to HUGE)
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    HUGE: KIAA1623

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANO8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANO8 gene:
    Search GeneIP for patents involving ANO8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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