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Aliases for ANO7 Gene

Aliases for ANO7 Gene

  • Anoctamin 7 2 3 5
  • Transmembrane Protein 16G 2 3 4
  • PCANAP5 3 4
  • TMEM16G 3 4
  • D-TMPP 3 4
  • IPCA-5 3 4
  • NGEP 3 4
  • Dresden-Transmembrane Protein Of The Prostate 3
  • Dresden Transmembrane Protein Of The Prostate 4
  • Prostate Cancer Associated Protein 5 3
  • Prostate Cancer-Associated Protein 5 4
  • New Gene Expressed In Prostate 4
  • PCANAP5L 3
  • DTMPP 3
  • IPCA5 3

External Ids for ANO7 Gene

Previous HGNC Symbols for ANO7 Gene

  • PCANAP5
  • TMEM16G

Previous GeneCards Identifiers for ANO7 Gene

  • GC02P241776
  • GC02P242127
  • GC02P233884

Summaries for ANO7 Gene

Entrez Gene Summary for ANO7 Gene

  • This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011]

GeneCards Summary for ANO7 Gene

ANO7 (Anoctamin 7) is a Protein Coding gene. Diseases associated with ANO7 include prostate cancer. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include intracellular calcium activated chloride channel activity and phospholipid scramblase activity. An important paralog of this gene is ANO5.

UniProtKB/Swiss-Prot for ANO7 Gene

  • Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANO7 Gene

Genomics for ANO7 Gene

Regulatory Elements for ANO7 Gene

Enhancers for ANO7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANO7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANO7 Gene

Chromosome:
2
Start:
241,188,509 bp from pter
End:
241,239,595 bp from pter
Size:
51,087 bases
Orientation:
Plus strand

Genomic View for ANO7 Gene

Genes around ANO7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANO7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANO7 Gene

Proteins for ANO7 Gene

  • Protein details for ANO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IWH7-ANO7_HUMAN
    Recommended name:
    Anoctamin-7
    Protein Accession:
    Q6IWH7
    Secondary Accessions:
    • Q6IWH6

    Protein attributes for ANO7 Gene

    Size:
    933 amino acids
    Molecular mass:
    105532 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The term anoctamin was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

    Alternative splice isoforms for ANO7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANO7 Gene

Proteomics data for ANO7 Gene at MOPED

Post-translational modifications for ANO7 Gene

  • Glycosylation at Asn 809 and Asn 824
  • Modification sites at PhosphoSitePlus

Other Protein References for ANO7 Gene

No data available for DME Specific Peptides for ANO7 Gene

Domains & Families for ANO7 Gene

Gene Families for ANO7 Gene

Protein Domains for ANO7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANO7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IWH7

UniProtKB/Swiss-Prot:

ANO7_HUMAN :
  • Belongs to the anoctamin family.
Family:
  • Belongs to the anoctamin family.
genes like me logo Genes that share domains with ANO7: view

Function for ANO7 Gene

Molecular function for ANO7 Gene

UniProtKB/Swiss-Prot Function:
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions.
UniProtKB/Swiss-Prot Induction:
Up-regulated by androgen.

Gene Ontology (GO) - Molecular Function for ANO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005229 intracellular calcium activated chloride channel activity TAS --
genes like me logo Genes that share ontologies with ANO7: view

Phenotypes for ANO7 Gene

genes like me logo Genes that share phenotypes with ANO7: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANO7 Gene

Localization for ANO7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANO7 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein. Cell junction. Endoplasmic reticulum. Note=Concentrates at sites of cell-cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604. {ECO:0000269 PubMed:17308099, ECO:0000269 PubMed:20056604, ECO:0000269 PubMed:22075693}.
Isoform 2: Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANO7 Gene COMPARTMENTS Subcellular localization image for ANO7 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
cytosol 4
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ANO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with ANO7: view

Pathways & Interactions for ANO7 Gene

genes like me logo Genes that share pathways with ANO7: view

Pathways by source for ANO7 Gene

Interacting Proteins for ANO7 Gene

Gene Ontology (GO) - Biological Process for ANO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0055085 transmembrane transport TAS --
GO:0061591 calcium activated galactosylceramide scrambling IEA --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with ANO7: view

No data available for SIGNOR curated interactions for ANO7 Gene

Drugs & Compounds for ANO7 Gene

(1) Drugs for ANO7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for ANO7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
genes like me logo Genes that share compounds with ANO7: view

Transcripts for ANO7 Gene

Unigene Clusters for ANO7 Gene

Anoctamin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANO7 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for ANO7 Gene

GeneLoc Exon Structure for
ANO7
ECgene alternative splicing isoforms for
ANO7

Expression for ANO7 Gene

mRNA expression in normal human tissues for ANO7 Gene

mRNA differential expression in normal tissues according to GTEx for ANO7 Gene

This gene is overexpressed in Prostate (x22.2), Colon - Transverse (x11.2), Stomach (x4.8), and Small Intestine - Terminal Ileum (x4.6).

Protein differential expression in normal tissues from HIPED for ANO7 Gene

This gene is overexpressed in Prostate (37.8) and Brain (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANO7 Gene



SOURCE GeneReport for Unigene cluster for ANO7 Gene Hs.163909

mRNA Expression by UniProt/SwissProt for ANO7 Gene

Q6IWH7-ANO7_HUMAN
Tissue specificity: Specifically expressed in epithelial cells of the prostate (at protein level).
genes like me logo Genes that share expression patterns with ANO7: view

Protein tissue co-expression partners for ANO7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ANO7 Gene

Orthologs for ANO7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANO7 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ANO7 35
  • 83.87 (n)
  • 78.05 (a)
ANO7 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ano7 35
  • 83.61 (n)
  • 83.84 (a)
Ano7 16
Ano7 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ano7 35
  • 83.35 (n)
  • 83.51 (a)
oppossum
(Monodelphis domestica)
Mammalia ANO7 36
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANO7 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANO7 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANO7 36
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ano7 35
  • 62.26 (n)
  • 60.74 (a)
ANO7 36
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea anoh-1 36
  • 25 (a)
OneToOne
Species with no ortholog for ANO7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ANO7 Gene

ENSEMBL:
Gene Tree for ANO7 (if available)
TreeFam:
Gene Tree for ANO7 (if available)

Paralogs for ANO7 Gene

Paralogs for ANO7 Gene

(7) SIMAP similar genes for ANO7 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ANO7 Gene

genes like me logo Genes that share paralogs with ANO7: view

Variants for ANO7 Gene

Sequence variations from dbSNP and Humsavar for ANO7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_032616 -
rs7590653 - 241,223,944(+) AGCCC(A/G)AGGGC intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs749264 -- 241,215,892(-) TCTGT(G/T)TCTGT intron-variant
rs749265 -- 241,215,814(-) ATGGG(C/T)TCCTC intron-variant
rs1808992 -- 241,206,158(-) GCCCA(C/G)CTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANO7 Gene

Variant ID Type Subtype PubMed ID
nsv876116 CNV Loss 21882294
nsv3241 CNV Insertion 18451855
dgv4492n71 CNV Loss 21882294
nsv508900 CNV Insertion 20534489
nsv527790 CNV Loss 19592680
nsv876223 CNV Loss 21882294
nsv524008 CNV Gain 19592680
nsv470532 CNV Loss 18288195
nsv521716 CNV Loss 19592680
esv2721986 CNV Deletion 23290073
esv2721987 CNV Deletion 23290073
esv2721988 CNV Deletion 23290073
esv26159 CNV Loss 19812545
esv2647088 CNV Deletion 19546169
esv2674511 CNV Deletion 23128226
nsv513025 CNV Loss 21212237
esv2721989 CNV Deletion 23290073
esv1000552 CNV Deletion 20482838
esv1409539 CNV Deletion 17803354
esv1480304 CNV Deletion 17803354
esv2721990 CNV Deletion 23290073
esv2721991 CNV Deletion 23290073
esv1026368 CNV Deletion 17803354
esv995493 CNV Deletion 20482838
nsv214015 CNV Loss 16902084
nsv3242 CNV Insertion 18451855
esv2721992 CNV Deletion 23290073

Variation tolerance for ANO7 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.47; 92.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANO7 Gene

HapMap Linkage Disequilibrium report
ANO7
Human Gene Mutation Database (HGMD)
ANO7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANO7 Gene

Disorders for ANO7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANO7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search ANO7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ANO7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANO7
genes like me logo Genes that share disorders with ANO7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANO7 Gene

Publications for ANO7 Gene

  1. Characterization of human TMEM16G gene in silico. (PMID: 15375614) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 4 23 67
  2. NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate. (PMID: 14981236) Bera T.K. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 23
  3. Structure and function of TMEM16 proteins (anoctamins). (PMID: 24692353) Pedemonte N. … Galietta L.J. (Physiol. Rev. 2014) 2 3
  4. Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level. (PMID: 18676855) Das S. … Pastan I. (Cancer Res. 2008) 3 23
  5. Study of NGEP expression pattern in cancerous tissues provides novel insights into prognostic marker in prostate cancer. (PMID: 25808443) Mohsenzadegan M. … Farajollahi M.M. (Biomark Med 2015) 3

Products for ANO7 Gene

Sources for ANO7 Gene

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