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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANO7 Gene

protein-coding   GIFtS: 49
GCID: GC02P242127

anoctamin 7

(Previous name: transmembrane protein 16G )
(Previous symbols: PCANAP5, TMEM16G)
 Explore 2 diseases affiliated with
ANO7 via our new
 Human Malady Compendium 
Biological research products
for ANO7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Anoctamin 71 2     DTMPP2 5
NGEP1 2 3 5     IPCA52 5
PCANAP51 2 3 5     Anoctamin-71
TMEM16G1 2 3 5     Dresden-Transmembrane Protein Of The Prostate2
Transmembrane Protein 16G1 2 3     Prostate Cancer Associated Protein 52
IPCA-51 2 3     Dresden Transmembrane Protein Of The Prostate3
PCANAP5L1 2     New Gene Expressed In Prostate3
D-TMPP2 3     Prostate Cancer-Associated Protein 53

External Ids:    HGNC: 316771   Entrez Gene: 506362   Ensembl: ENSG000001462057   OMIM: 6050965   UniProtKB: Q6IWH73   

Export aliases for ANO7 gene to outside databases

Previous GC identifers: GC02P241776 GC02P233884


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANO7:
This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a
target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants
encoding different isoforms. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: ANO7_HUMAN, Q6IWH7
Function: Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell
interactions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005416.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANO7 gene promoter:
         NF-1   Pax-5   CUTL1   MEF-2A   CREB   E2F   POU2F1   POU2F1a   deltaCREB   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANO7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANO7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANO7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

ANO7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANO7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P242127:  view genomic region     (about GC identifiers)

Start:
242,127,924 bp from pter      End:
242,164,792 bp from pter
Size:
36,869 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANO7_HUMAN, Q6IWH7 (See protein sequence)
Recommended Name: Anoctamin-7  
Size: 933 amino acids; 105532 Da
Subcellular location: Isoform 1: Cell membrane; Multi-pass membrane protein. Cell junction. Endoplasmic reticulum.
Note=Concentrates at sites of cell-cell contact. Shows an intracellular localization according to PubMed:22075693 and
PubMed:20056604
Subcellular location: Isoform 2: Cytoplasm, cytosol
Miscellaneous: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT)
transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain
that all the members of this family are anion channels or have the 8-transmembrane topology
Caution: It is uncertain whether Met-1 or Met-55 is the initiator
Secondary accessions: Q6IWH6
Alternative splicing: 3 isoforms:  Q6IWH7-1   Q6IWH7-2   Q6IWH7-3   

Explore the universe of human proteins at neXtProt for ANO7: NX_Q6IWH7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6IWH7

  • ANO7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001666.1  NP_001001891.2  

    ENSEMBL proteins: 
     ENSP00000274979   ENSP00000383985   ENSP00000385418   ENSP00000403625  
    Reactome Protein details: Q6IWH7
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    Uscn Proteins for ANO7

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IDA14981236


    ANO7 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ANO7 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007632 Anoctamin

    Graphical View of Domain Structure for InterPro Entry Q6IWH7

    ProtoNet protein and cluster: Q6IWH7

    UniProtKB/Swiss-Prot: ANO7_HUMAN, Q6IWH7
    Similarity: Belongs to the anoctamin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ANO7_HUMAN, Q6IWH7
    Function: Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell
    interactions
    Induction: Up-regulated by androgen

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005229NOT intracellular calcium activated chloride channel activity IDA--
    GO:0005254chloride channel activity ----


    ANO7 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ion channel transport
    Ion channel transport1.00
    Stimuli-sensing channels0.49
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for ANO7
        Transmembrane transport of small molecules
    Stimuli-sensing channels
    Ion channel transport



    ANO7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANO7

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport ----


    ANO7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANO7

    2 HMDB Compounds for ANO7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--
    Search CenterWatch for drugs/clinical trials and news about ANO7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANO7 gene (2 alternative transcripts): 
    NM_001001666.3  NM_001001891.3  

    Unigene Cluster for ANO7:

    Anoctamin 7
    Hs.163909  [show with all ESTs]
    Unigene Representative Sequence: NM_001001891
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274979(uc002wax.2) ENST00000402530(uc002waw.3) ENST00000402430
    ENST00000475532 ENST00000471606 ENST00000451047 ENST00000487192 ENST00000481071
    ENST00000459928

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK057322.1 AY617079.1 AY617080.1 BC028162.1 BC038852.1 BC047903.1 

    8 DOTS entries:

    DT.95224407  DT.102824360  DT.102824361  DT.121031229  DT.97793252  DT.100752254  DT.95100630  DT.100752255 

    24/36 AceView cDNA sequences (see all 36):

    AI299378 CB104799 BC028162 CR607745 AK057322 BC047903 BX089957 H79732 
    BI768347 BC038852 AA666320 BM999866 BQ218672 NM_001001891 CD672346 NM_001001666 
    AI202654 AY617080 BX282274 BI859358 AF109300 BF856434 BM792141 AY617079 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ANO7    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:        -                                   -                                             
    SP2:                                            -                                             
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for ANO7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANO7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGTCGGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ANO7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANO7

    SOURCE GeneReport for Unigene cluster: Hs.163909

    UniProtKB/Swiss-Prot: ANO7_HUMAN, Q6IWH7
    Tissue specificity: Specifically expressed in epithelial cells of the prostate (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANO7 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia ANO76
    --
    68(a)
    1 ↔ 1
    3(30176380-30203750)
    zebrafish
    (Danio rerio)
    Actinopterygii ano71 anoctamin 7 63.65(n)
    63.02(a)
      556876  XM_679798.3  XP_684890.3 
    worm
    (Caenorhabditis elegans)
    Secernentea anoh-11 Protein ANOH-1 42.98(n)
    33.84(a)
      176739  NM_067328.2  NP_499729.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G730206
    uncharacterized protein
    19(a)
    1 → many
    1(27469534-27473554)
    rice
    (Oryza sativa)
    Liliopsida --
    transmembrane protein 16K, putative, expressed
    19(a)
    1 → many
    1(29317147-29321524)


    ENSEMBL Gene Tree for ANO7 (if available)
    TreeFam Gene Tree for ANO7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANO7 gene
    ANO92  ANO62  ANO22  ANO52  ANO12  ANO102  ANO32  ANO42  
    ANO82  
    7 SIMAP similar genes for ANO7 using alignment to 3 protein entries:     ANO7_HUMAN (see all proteins):
    ANO3    ANO1    ANO9    ANO4    ANO5    ANO2
    ANO6

    ANO7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ANO7
    PGOHUM00000243910 PGOHUM00000243911


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/975 NCBI SNPs in ANO7 are shown (see all 975    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs46758271,2
    C,A,H,--242125975(-) GTTCAC/TGCCAT 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1424478201,2
    --242125980(+) ATGAAC/TCCGGG 2 -- us2k10--------
    rs1860613581,2
    --242126005(+) GTGAGC/TCGAGA 2 -- us2k10--------
    rs1463131661,2
    --242126025(+) TGCACG/TCCAGC 2 -- us2k10--------
    rs1390357121,2
    --242126029(+) CTCCAA/GCCTGG 2 -- us2k10--------
    rs1913756171,2
    --242126045(+) AGAGCC/GAGACT 2 -- us2k10--------
    rs124722171,2
    C,F,H,--242126109(+) GGGCCT/CGGGCT 2 -- us2k18Minor allele frequency- C:0.16NA CSA WA EA 371
    rs750905281,2
    --242126137(+) CCTGGC/TGGGCC 2 -- us2k10--------
    rs350941311,2
    C,--242126211(+) ACTTG-/AAAAAA 2 -- us2k12Minor allele frequency- A:0.00NA CSA 4
    rs1501649791,2
    --242126264(+) CACTCA/CTCAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANO7 (242127924 - 242164792 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ANO7
         2 CNVs: 98191 68297
         2 Indels: 26634 26633
    Human Gene Mutation Database (HGMD): ANO7

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ANO7 for disorders           About GeneDecksing

    OMIM gene information: 605096    OMIM disorders: --

    2 diseases for ANO7:    About MalaCards
    prostate cancer    prostatitis


    Export disorders for ANO7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANO7 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ANO7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human TMEM16G gene in silico. (PubMed id 15375614)1, 2, 3, 9 Katoh M. and Katoh M. (2004)
    2. NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate. (PubMed id 14981236)1, 2, 3, 9 Bera T.K.... Pastan I. (2004)
    3. Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level. (PubMed id 18676855)1, 2, 9 Das S....Pastan I. (2008)
    4. D-TMPP: a novel androgen-regulated gene preferentially expressed in prostate and prostate cancer that is the first characterized member of an eukaryotic gene family. (PubMed id 15761874)1, 2 Kiessling A.... Rieber E.P. (2005)
    5. Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes. (PubMed id 10613842)1, 2 Walker M.G.... Klingler T. (1999)
    6. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. (PubMed id 21984732)2 Scudieri P.... Galietta L.J. (2012)
    7. ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. (PubMed id 22075693)2 Duran C.... Hartzell H.C. (2012)
    8. Anoctamins are a family of Ca2+ activated Cl- channels. (PubMed id 22946059)2 Tian Y.... Kunzelmann K. (2012)
    9. The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age. (PubMed id 22302790)2 Winpenny J.P. and Gray M.A. (2012)
    10. Anoctamins. (PubMed id 21607626)2 Kunzelmann K.... Schreiber R. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50636 HGNC: 31677 AceView: PCANAP5 Ensembl:ENSG00000146205 euGenes: HUgn50636
    ECgene: ANO7 H-InvDB: ANO7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANO7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANO7 gene:
    Search GeneIP for patents involving ANO7

    GeneCards and IP:
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